Search

Your search keyword '"Detty, Michael R."' showing total 41 results
Start Over Author "Detty, Michael R." Publication Year Range Last 10 years
41 results on '"Detty, Michael R."'

5. Bromochloromethane (BrCH 2 Cl)

Author

Detty, Michael, R., primary, Bateman, Margaret, additional, Wilde, Victoria, additional, Castiglione, Davide, additional, and Pace, Vittorio, additional

Published
2023
Full Text
View/download PDF

8. Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation

Author

Andreou, Chrysafis, primary, Plakas, Konstantinos, additional, Berisha, Naxhije, additional, Gigoux, Mathieu, additional, Rosch, Lauren E., additional, Mirsafavi, Rustin, additional, Oseledchyk, Anton, additional, Pal, Suchetan, additional, Zamarin, Dmitriy, additional, Merghoub, Taha, additional, Detty, Michael R., additional, and Kircher, Moritz F., additional

Published
2022
Full Text
View/download PDF

12. Multiplex imaging of live breast cancer tumour models through tissue using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS)

Author

Nicolson, Fay, Jamieson, Lauren E., Mabbott, Samuel, Plakas, Konstantinos, Shand, Neil C., Detty, Michael R., Graham, Duncan, and Faulds, Karen

Subjects
QD
Abstract

Through utilizing the depth penetration capabilities of SESORS, multiplexed imaging and classification of three singleplex nanotags and a triplex of nanotags within breast cancer tumour models is reported for the first time through depths of 10 mm using a handheld SORS instrument.

Published
2018

15. Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice viamultichannel image segmentationElectronic supplementary information (ESI) available: Online Methods, Fig. S1–S10 and Tables S1, S2. See DOI: https://doi.org/10.1039/d2nh00331g

Author

Andreou, Chrysafis, Plakas, Konstantinos, Berisha, Naxhije, Gigoux, Mathieu, Rosch, Lauren E., Mirsafavi, Rustin, Oseledchyk, Anton, Pal, Suchetan, Zamarin, Dmitriy, Merghoub, Taha, Detty, Michael R., and Kircher, Moritz F.

Abstract

Visualizing the presence and distribution of multiple specific molecular markers within a tumor can reveal the composition of its microenvironment, inform diagnosis, stratify patients, and guide treatment. Raman imaging with multiple molecularly-targeted surface enhanced Raman scattering (SERS) nanoprobes could help investigate emerging cancer treatments preclinically or enable personalized treatment assessment. Here, we report a comprehensive strategy for multiplexed imaging using SERS nanoprobes and machine learning (ML) to monitor the early effects of immune checkpoint blockade (ICB) in tumor-bearing mice. We used antibody-functionalized SERS nanoprobes to visualize 7 + 1 immunotherapy-related targets simultaneously. The multiplexed images were spectrally resolved and then spatially segmented into superpixels based on the unmixed signals. The superpixels were used to train ML models, leading to the successful classification of mice into treated and untreated groups, and identifying tumor regions with variable responses to treatment. This method may help predict treatment efficacy in tumors and identify areas of tumor variability and therapy resistance.

Published
2022
Full Text
View/download PDF

22. Multivariate analysis of attachment of biofouling organisms in response to material surface characteristics

Author

Gatley-Montross, Caitlyn M., primary, Finlay, John A., additional, Aldred, Nick, additional, Cassady, Harrison, additional, Destino, Joel F., additional, Orihuela, Beatriz, additional, Hickner, Michael A., additional, Clare, Anthony S., additional, Rittschof, Daniel, additional, Holm, Eric R., additional, and Detty, Michael R., additional

Published
2017
Full Text
View/download PDF

26. Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease

Author

McIver, Zachariah A., primary, Grayson, Jason M., additional, Coe, Benjamin N., additional, Hill, Jacqueline E., additional, Schamerhorn, Gregory A., additional, Ohulchanskyy, Tymish Y., additional, Linder, Michelle K., additional, Davies, Kellie S., additional, Weiner, Roy S., additional, and Detty, Michael R., additional

Published
2016
Full Text
View/download PDF

30. Reductive Side of Water Splitting in Artificial Photosynthesis: New Homogeneous Photosystems of Great Activity and Mechanistic Insight

Author

McCormick, Theresa M., Calitree, Brandon D., Orchard, Alexandra, Kraut, Nadine D., Bright, Frank V., Detty, Michael R., and Eisenberg, Richard

Abstract

Rhodamine photosensitizers (PSs) substituting S or Se for O in the xanthene ring give turnover numbers (TONs) as high as 9000 for the generation of hydrogen via the reduction of water using [CoIII(dmgH)2(py)Cl] (where dmgH = dimethylglyoximate and py = pyridine) as the catalyst and triethanolamine as the sacrificial electron donor. The turnover frequencies were 0, 1700, and 5500 mol H2/mol PS/h for O, S, and Se derivatives, respectively (ΦH2= 0%, 12.2%, and 32.8%, respectively), which correlates well with relative triplet yields estimated from quantum yields for singlet oxygen generation. Phosphorescence from the excited PS was quenched by the sacrificial electron donor. Fluorescence lifetimes were similar for the O- and S-containing rhodamines (∼2.6 ns) and shorter for the Se analog (∼0.1 ns). These data suggest a reaction pathway involving reductive quenching of the triplet excited state of the PS giving the reduced PS−that then transfers an electron to the Co catalyst. The longer-lived triplet state is necessary for effective bimolecular electron transfer. While the cobalt/rhodamine/triethanolamine system gives unprecedented yields of hydrogen for the photoreduction of water, mechanistic insights regarding the overall reaction pathway as well as system degradation offer significant guidance to developing even more stable and efficient photocatalytic systems.

Published
2024
Full Text
View/download PDF

33. P-Glycoprotein Modulation Facilitates the Selective Inhibition of Oxidative Phosphorylation in Alloreactive T Cells to Prevent Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplant

Author

McIver, Zachariah A., primary, Phipps, James P, additional, Grayson, Jason M, additional, Hill, Jacqueline E, additional, Schamerhorn, Gregory A, additional, Ohulchanskyy, Tymish Y, additional, Linder, Michelle K, additional, Davies, Kellie S, additional, Weiner, Roy S, additional, and Detty, Michael R, additional

Published
2015
Full Text
View/download PDF

37. Xerogel-Sequestered Silanated Organochalcogenide Catalysts for Bromination with Hydrogen Peroxide and Sodium Bromide.

Author

Gatley, Caitlyn M., Muller, Lisa M., Lang, Meredith A., Alberto, Eduardo E., and Detty, Michael R.

Subjects
XEROGELS, BROMINATION, HYDROGEN peroxide, SODIUM bromide, ORGANOTELLURIUM compounds, ORGANOSELENIUM compounds
Abstract

While H2O2 is a powerful oxidant, decomposing into environmentally benign H2O and O2, a catalyst is often required for reactions with H2O2 to proceed at synthetically useful rates. Organotellurium and organoselenium compounds catalyze the oxidation of halide salts to hypohalous acids using H2O2. When sequestered into xerogel monoliths, the xerogel-chalcogenide combinations have demonstrated increased catalytic activity relative to the organochalcogen compound alone in solution for the oxidation of halide salts to hypohalous acids with H2O2. Diorganotellurides, diorganoselenides, and diorganodiselenides bearing triethoxysilane functionalities were sequestered into xerogel monoliths and their catalytic activity and longevity were investigated. The longevity of the catalyst-xerogel combinations was examined by isolating and recycling the catalyst-xerogel combination. It was found tellurium-containing catalyst 3 and selenium-containing catalyst 8 maintained their catalytic activity through three recycling trials and adding electron-donating substituents to catalyst 3 also increased the catalytic rate. The presence of organotellurium and organoselenium groups in the +4 oxidation state was determined by X-ray photoelectron spectroscopy. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

39. Extreme red shifted SERS nanotags.

Author

Bedics, Matthew A., Kearns, Hayleigh, Cox, Jordan M., Mabbott, Sam, Ali, Fatima, Shand, Neil C., Faulds, Karen, Benedict, Jason B., Graham, Duncan, and Detty, Michael R.

Published
2015
Full Text
View/download PDF

40. Correction: Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice viamultichannel image segmentation

Author

Andreou, Chrysafis, Plakas, Konstantinos, Berisha, Naxhije, Gigoux, Mathieu, Rosch, Lauren E., Mirsafavi, Rustin, Oseledchyk, Anton, Pal, Suchetan, Zamarin, Dmitriy, Merghoub, Taha, Detty, Michael R., and Kircher, Moritz F.

Abstract

Correction for ‘Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice viamultichannel image segmentation’ by Chrysafis Andreou et al., Nanoscale Horiz., 2022, 7, 1540–1552, https://doi.org/10.1039/d2nh00331g.

Published
2023
Full Text
View/download PDF

41. Correction: Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation.

Author

Andreou C, Plakas K, Berisha N, Gigoux M, Rosch LE, Mirsafavi R, Oseledchyk A, Pal S, Zamarin D, Merghoub T, Detty MR, and Kircher MF

Abstract

Correction for 'Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation' by Chrysafis Andreou et al. , Nanoscale Horiz. , 2022, 7 , 1540-1552, https://doi.org/10.1039/d2nh00331g.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results