1,783 results on '"De Paulis, A."'
Search Results
2. Clinical features and potential markers of disease in idiopathic non-histaminergic angioedema, a real-life study
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Mormile, Ilaria, Gigliotti, Maria Celeste, Ferrara, Anne Lise, Gatti, Roberta, Spadaro, Giuseppe, de Paulis, Amato, Loffredo, Stefania, Bova, Maria, and Petraroli, Angelica
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- 2024
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3. Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years
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Stoica, Serban, Beard, Chloe, Takkenberg, Johanna JM, Mokhles, Mostafa M, Turner, Mark, Pepper, John, Hopewell-Kelly, Noreen, Benedetto, Umberto, Nashef, Samer AM, El-Hamamsy, Ismail, Skillington, Peter, Glauber, Mattia, De Paulis, Ruggero, Tseng, Elaine, Meuris, Bart, Sitges, Marta, Delgado, Victoria, Krane, Markus, Kostolny, Martin, and Pufulete, Maria
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Clinical Research ,Cardiovascular ,Aging ,Transplantation ,Heart Disease ,Patient Safety ,Humans ,Adult ,Aortic Valve ,Heart Valve Prosthesis Implantation ,Aortic Valve Stenosis ,Autografts ,Treatment Outcome ,Transplantation ,Autologous ,Heart Valve Prosthesis ,Transcatheter Aortic Valve Replacement ,heart valve prosthesis ,transcatheter aortic valve replacement ,aortic valve insufficiency ,aortic valve stenosis ,heart valve prosthesis implantation ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectiveThere is uncertainty about surgical procedures for adult patients aged 18-60 years undergoing aortic valve replacement (AVR). Options include conventional AVR (mechanical, mAVR; tissue, tAVR), the pulmonary autograft (Ross) and aortic valve neocuspidisation (Ozaki). Transcatheter treatment may be an option for selected patients. We used formal consensus methodology to make recommendations about the suitability of each procedure.MethodsA working group, supported by a patient advisory group, developed a list of clinical scenarios across seven domains (anatomy, presentation, cardiac/non-cardiac comorbidities, concurrent treatments, lifestyle, preferences). A consensus group of 12 clinicians rated the appropriateness of each surgical procedure for each scenario on a 9-point Likert scale on two separate occasions (before and after a 1-day meeting).ResultsThere was a consensus that each procedure was appropriate (A) or inappropriate (I) for all clinical scenarios as follows: mAVR: total 76% (57% A, 19% I); tAVR: total 68% (68% A, 0% I); Ross: total 66% (39% A, 27% I); Ozaki: total 31% (3% A, 28% I). The remainder of percentages to 100% reflects the degree of uncertainty. There was a consensus that transcatheter aortic valve implantation is appropriate for 5 of 68 (7%) of all clinical scenarios (including frailty, prohibitive surgical risk and very limited life span).ConclusionsEvidence-based expert opinion emerging from a formal consensus process indicates that besides conventional AVR options, there is a high degree of certainty about the suitability of the Ross procedure in patients aged 18-60 years. Future clinical guidelines should include the option of the Ross procedure in aortic prosthetic valve selection.
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- 2023
4. Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients
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Luca Modestino, Manuela Tumminelli, Ilaria Mormile, Leonardo Cristinziano, Annagioia Ventrici, Marialuisa Trocchia, Anne Lise Ferrara, Francesco Palestra, Stefania Loffredo, Gianni Marone, Francesca Wanda Rossi, Amato de Paulis, and Maria Rosaria Galdiero
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neutrophils ,neutrophil extracellular traps ,psoriatic arthritis ,inflammation ,innate immunity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundNeutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and are among the main actors in the inflammatory response. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting both the axial and peripheral joints. Typically associated with psoriasis, PsA can also affect multiple systems and organs, including the nails and entheses. Despite the involvement of PMNs in PsA, their specific role in the disease remains poorly understood. This study aimed to characterize the biological functions of PMNs and neutrophil-related mediators in PsA patients.Materials and methods31 PsA patients and 22 healthy controls (HCs) were prospectively recruited. PMNs were isolated from peripheral blood and subjected to in vitro stimulation with lipopolysaccharide (LPS), N-Formylmethionyl-leucyl-phenylalanine (fMLP), tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate (PMA), or control medium. Highly purified peripheral blood PMNs (>99%) were evaluated for activation status, reactive oxygen species (ROS) production, phagocytic activity, granular enzyme and neutrophil extracellular traps (NETs) release. Serum levels of matrix metalloproteinase-9 (MMP-9), myeloperoxidase (MPO), TNF, interleukin 23 (IL-23), and interleukin 17 (IL-17) were measured by ELISA. Serum Citrullinated histone H3 (CitH3) was measured as a NET biomarker.ResultsActivated PMNs from PsA patients displayed reduced activation, decreased ROS production, and impaired phagocytic activity upon stimulation with TNF, compared to HCs. PMNs from PsA patients also displayed reduced granular enzyme (MPO) and NET release. Serum analyses revealed elevated levels of MMP-9, MPO, TNF, IL-23, IL-17, and CitH3 in PsA patients compared to HCs. Serum CitH3 levels positively correlated with MPO and TNF concentrations, and IL-17 concentrations were positively correlated with IL-23 levels in PsA patients. These findings indicate that PMNs from PsA patients show reduced in vitro activation and function, and an increased presence of neutrophil-derived mediators (MMP-9, MPO, TNF, IL-23, IL-17, and CitH3) in their serum.ConclusionsTaken together, our findings suggest that PMNs from PsA patients exhibit an “exhausted” phenotype, highlighting their plasticity and multifaceted roles in PsA pathophysiology.
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- 2024
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5. A Sign in Space: Global collaboration as cosmic theatre.
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Daniela de Paulis
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- 2024
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6. PAM3: History, Algorithm, and Performance Comparison to NRZ and PAM4
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Chen, Sherman Shan, de Paulis, Francesco, Stauffer, David R., Holden, Brian, Kaushik, Brajesh Kumar, Series Editor, Kolhe, Mohan Lal, Series Editor, Agrawal, Yash, editor, Mummaneni, Kavicharan, editor, and Sathyakam, P. Uma, editor
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- 2024
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7. Clinical and laboratory features associated with macrophage activation syndrome in Still’s disease: data from the international AIDA Network Still’s Disease Registry
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Triggianese, Paola, Vitale, Antonio, Lopalco, Giuseppe, Mayrink Giardini, Henrique Ayres, Ciccia, Francesco, Al-Maghlouth, Ibrahim, Ruscitti, Piero, Sfikakis, Petros Paul, Iannone, Florenzo, de Brito Antonelli, Isabele Parente, Patrone, Martina, Asfina, Kazi Nur, Di Cola, Ilenia, Laskari, Katerina, Gaggiano, Carla, Tufan, Abdurrahman, Sfriso, Paolo, Dagna, Lorenzo, Giacomelli, Roberto, Hinojosa-Azaola, Andrea, Ragab, Gaafar, Fotis, Lampros, Direskeneli, Haner, Spedicato, Veronica, Dagostin, Marilia Ambiel, Iacono, Daniela, Ali, Hebatallah Hamed, Cipriani, Paola, Sota, Jurgen, Kardas, Riza Can, Bindoli, Sara, Campochiaro, Corrado, Navarini, Luca, Gentileschi, Stefano, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Saad, Moustafa Ali, Kourtesi, Katerina, Alibaz-Oner, Fatma, Sevik, Gizem, Iagnocco, Annamaria, Makowska, Joanna, Govoni, Marcello, Monti, Sara, Maggio, Maria Cristina, La Torre, Francesco, Del Giudice, Emanuela, Hernández-Rodríguez, José, Bartoloni, Elena, Emmi, Giacomo, Chimenti, Maria Sole, Maier, Armin, Simonini, Gabriele, Conti, Giovanni, Olivieri, Alma Nunzia, Tarsia, Maria, De Paulis, Amato, Lo Gullo, Alberto, Więsik-Szewczyk, Ewa, Viapiana, Ombretta, Ogunjimi, Benson, Tharwat, Samar, Erten, Sukran, Nuzzolese, Rossana, Karamanakos, Anastasios, Frassi, Micol, Conforti, Alessandro, Caggiano, Valeria, Marino, Achille, Sebastiani, Gian Domenico, Gidaro, Antonio, Tombetti, Enrico, Carubbi, Francesco, Rubegni, Giovanni, Cartocci, Alessandra, Balistreri, Alberto, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca
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- 2023
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8. Unfolding dermatologic spectrum of Behçet’s disease in Italy: real-life data from the International AIDA Network Behçet’s disease Registry
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D’Onghia, Martina, Cinotti, Elisa, Cartocci, Alessandra, Vitale, Antonio, Caggiano, Valeria, Tognetti, Linda, La Marca, Francesca, Sota, Jurgen, Gentileschi, Stefano, Rubegni, Giovanni, Lopalco, Giuseppe, Guerriero, Silvana, Govoni, Marcello, Monti, Sara, Ruscitti, Piero, Angeli, Fabrizio, Carubbi, Francesco, Giacomelli, Roberto, Ciccia, Francesco, Piga, Matteo, Emmi, Giacomo, Costi, Stefania, Sebastiani, Gian Domenico, Iannone, Florenzo, Spedicato, Veronica, Alessio, Giovanni, Ruffilli, Francesca, Milanesi, Alessandra, Gentile, Martina, Crisafulli, Francesca, Alunno, Alessia, Navarini, Luca, Iacono, Daniela, Cauli, Alberto, Ricci, Francesca, Gaggiano, Carla, Tarsia, Maria, Bartoloni, Elena, Conti, Giovanni, Viapiana, Ombretta, Gobbi, Francesca Li, de Paulis, Amato, Parronchi, Paola, Del Giudice, Emanuela, Barone, Patrizia, Olivieri, Alma Nunzia, Bizzi, Emanuele, Maggio, Maria Cristina, Balistreri, Alberto, Frediani, Bruno, Tosi, Gian Marco, Fabiani, Claudia, Rubegni, Pietro, and Cantarini, Luca
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- 2023
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9. Effects of COVID-19-targeted non-pharmaceutical interventions on pediatric emergency department use: a quasi-experimental study interrupted time-series analysis in North Italian hospitals, 2017 to 2022
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Matteo Puntoni, Giuseppe Maglietta, Caterina Caminiti, Angela Miniaci, Marcello Lanari, Fabio Caramelli, Federico Marchetti, Alessandro De Fanti, Lorenzo Iughetti, Giacomo Biasucci, Agnese Suppiej, Andrea Miceli, Chiara Ghizzi, Gianluca Vergine, Melodie Aricò, Marcello Stella, Susanna Esposito, the Emilia-Romagna Paediatric COVID-19 network, Francesca Diodati, Chiara Maria Palo, Luca Bertelli, Giovanni Biserni, Angela Troisi, Alessandra Iacono, Federico Bonvicini, Domenico Bartolomeo, Andrea Trombetta, Tommaso Zini, Nicoletta de Paulis, Cristina Forest, Battista Guidi, Francesca Di Florio, Enrico Valletta, Francesco Accomando, Greta Ramundo, Alberto Argentiero, Valentina Fainardi, and Michela Deolmi
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COVID-19 epidemiology ,Non-Pharmaceutical Intervention ,quasi-experimental design ,Interrupted Time Series regression analysis ,Diseases of the Respiratory System ,mental disorders ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe use of Non-Pharmaceutical Interventions (NPIs) during the COVID-19 pandemic is debated. Understanding the consequences these measures may have on vulnerable populations including children and adolescents is important.MethodsThis is a multicenter, quasi-experimental before-after study involving 12 hospitals of the North Italian Emilia-Romagna Region, with NPI implementation as the intervention event. The 3 years preceding NPI implementation (in March 2020) constituted the pre-pandemic phase. The subsequent 2 years were further subdivided into a school closure phase (SC) and a subsequent mitigation measures phase (MM) with milder restrictions. Interrupted Time Series (ITS) regression analysis was used to calculate PED Standardized Incidence Rate Ratios (SIRR) on the diagnostic categories exhibiting the greatest frequency and/or variation.ResultsIn the 60 months of the study there were 765,215 PED visits. Compared to the pre-pandemic rate, overall PED presentations dropped by 58 and 39% during SC and MM, respectively. “Symptoms, signs and Ill-defined conditions,” “Injury and poisoning” and “Diseases of the Respiratory System” accounted for 74% of the reduction. A different pattern was instead seen for “Mental Disorders,” which exhibited the smallest decrease during SC, and is the only category which rose already at the end of SC. ITS analysis confirmed the strong decrease during SC (level change, IRR 0.17, 95%CI 0.12–0.27) and a significant increase in MM (slope change, IRR 1.23, 95%CI 1.13–1.33), with the sharpest decline (−94%) and rise (+36%) observed in the “Diseases of the Respiratory System” category. Mental Disorders showed a significant increasing trend of 1% monthly over the whole study period exceeding pre-pandemic levels at the end of MM. Females and adolescents showed higher increasing rates both in SC and MM.ConclusionNPIs appear to have influenced PED attendance in different ways according to diagnostic categories, mirroring different mechanisms of action. These effects are beneficial in some cases and harmful in others, and establishing a clear balance between pros and cons is a difficult task for public health decision makers. The role of NPIs on PED use appropriateness deserves investigation. The rise in pediatric mental disorders independent of the pandemic makes interventions addressing these issues urgent.
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- 2024
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10. A Compact and High-Efficiency Antenna Design for Tire Pressure Monitoring System Applications.
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Lei Deng, Lidong Chi, Francesco de Paulis, and Yihong Qi
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- 2024
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11. Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries
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Antonio Vitale, Valeria Caggiano, Abdurrahman Tufan, Gaafar Ragab, Ezgi Deniz Batu, Piero Portincasa, Emma Aragona, Jurgen Sota, Giovanni Conti, Amato De Paulis, Donato Rigante, Alma Nunzia Olivieri, Ali Şahin, Francesco La Torre, Giuseppe Lopalco, Marco Cattalini, Maria Cristina Maggio, Antonella Insalaco, Petros P. Sfikakis, Elena Verrecchia, Derya Yildirim, Hamit Kucuk, Riza Can Kardas, Ahmed Hatem Laymouna, Mahmoud Ghanema, Moustafa Ali Saad, Seher Sener, Hulya Ercan Emreol, Seza Ozen, Nour Jaber, Mohamad Khalil, Agostino Di Ciaula, Carla Gaggiano, Giuseppe Malizia, Andrea Affronti, Serena Patroniti, Meri Romeo, Jessica Sbalchiero, Francesca Della Casa, Ilaria Mormile, Sara Silvaroli, Maria Francesca Gicchino, Neşe Çabuk Çelik, Maria Tarsia, Anastasios Karamanakos, José Hernández-Rodríguez, Paola Parronchi, Daniela Opris-Belinski, Patrizia Barone, Andreas Recke, Stefania Costi, Paolo Sfriso, Henrique A. Mayrink Giardini, Stefano Gentileschi, Ewa Wiesik-Szewczyk, Ibrahim Vasi, Roberta Loconte, Karina Jahnz-Różyk, Eduardo Martín-Nares, Jiram Torres-Ruiz, Alberto Cauli, Alessandro Conforti, Giacomo Emmi, Francesca Li Gobbi, Giovanni Rosario Biasi, Riccardo Terribili, Piero Ruscitti, Emanuela Del Giudice, Samar Tharwat, Antonio Luca Brucato, Benson Ogunjimi, Andrea Hinojosa-Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, and Luca Cantarini
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autoinflammatory diseases ,FMF ,tumor ,neoplasm ,rare diseases ,treatment ,Immunologic diseases. Allergy ,RC581-607 - Abstract
ObjectiveInflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregulation. Therefore, the aim of this study is to investigate the risk for cancer development in FMF.MethodsThe risk ratio (RR) for malignancies was separately compared between FMF patients and fibromyalgia subjects, Still’s disease patients and Behçet’s disease patients. Clinical variables associated with cancer development in FMF patients were searched through binary logistic regression.Results580 FMF patients and 102 fibromyalgia subjects, 1012 Behçet’s disease patients and 497 Still’s disease patients were enrolled. The RR for the occurrence of malignant neoplasms was 0.26 (95% Confidence Interval [CI.] 0.10-0.73, p=0.006) in patients with FMF compared to fibromyalgia subjects; the RR for the occurrence of malignant cancer was 0.51 (95% CI. 0.23-1.16, p=0.10) in FMF compared to Still’s disease and 0.60 (95% CI. 0.29-1.28, p=0.18) in FMF compared to Behçet’s disease. At logistic regression, the risk of occurrence of malignant neoplasms in FMF patients was associated with the age at disease onset (β1 = 0.039, 95% CI. 0.001-0.071, p=0.02), the age at the diagnosis (β1 = 0.048, 95% CI. 0.039-0.085, p=0.006), the age at the enrolment (β1 = 0.05, 95% CI. 0.007-0.068, p=0.01), the number of attacks per year (β1 = 0.011, 95% CI. 0.001- 0.019, p=0.008), the use of biotechnological agents (β1 = 1.77, 95% CI. 0.43-3.19, p=0.009), the use of anti-IL-1 agents (β1 = 2.089, 95% CI. 0.7-3.5, p=0.002).ConclusionsThe risk for cancer is reduced in Caucasic FMF patients; however, when malignant neoplasms occur, this is more frequent in FMF cases suffering from a severe disease phenotype and presenting a colchicine-resistant disease.
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- 2024
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12. Correction: Clinical and laboratory features associated with macrophage activation syndrome in Still’s disease: data from the international AIDA Network Still’s Disease Registry
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Triggianese, Paola, Vitale, Antonio, Lopalco, Giuseppe, Mayrink Giardini, Henrique Ayres, Ciccia, Francesco, Al-Maghlouth, Ibrahim, Ruscitti, Piero, Sfikakis, Petros Paul, Iannone, Florenzo, de Brito Antonelli, Isabele Parente, Patrone, Martina, Asfina, Kazi Nur, Di Cola, Ilenia, Laskari, Katerina, Gaggiano, Carla, Tufan, Abdurrahman, Sfriso, Paolo, Dagna, Lorenzo, Giacomelli, Roberto, Hinojosa-Azaola, Andrea, Ragab, Gaafar, Fotis, Lampros, Direskeneli, Haner, Spedicato, Veronica, Dagostin, Marilia Ambiel, Iacono, Daniela, Ali, Hebatallah Hamed, Cipriani, Paola, Sota, Jurgen, Kardas, Riza Can, Bindoli, Sara, Campochiaro, Corrado, Navarini, Luca, Gentileschi, Stefano, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Saad, Moustafa Ali, Kourtesi, Katerina, Alibaz-Oner, Fatma, Sevik, Gizem, Iagnocco, Annamaria, Makowska, Joanna, Govoni, Marcello, Monti, Sara, Maggio, Maria Cristina, La Torre, Francesco, Del Giudice, Emanuela, Hernández-Rodríguez, José, Bartoloni, Elena, Emmi, Giacomo, Chimenti, Maria Sole, Maier, Armin, Simonini, Gabriele, Conti, Giovanni, Olivieri, Alma Nunzia, Tarsia, Maria, De Paulis, Amato, Lo Gullo, Alberto, Więsik-Szewczyk, Ewa, Viapiana, Ombretta, Ogunjimi, Benson, Tharwat, Samar, Erten, Sukran, Nuzzolese, Rossana, Karamanakos, Anastasios, Frassi, Micol, Conforti, Alessandro, Caggiano, Valeria, Marino, Achille, Sebastiani, Gian Domenico, Gidaro, Antonio, Tombetti, Enrico, Carubbi, Francesco, Rubegni, Giovanni, Cartocci, Alessandra, Balistreri, Alberto, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca
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- 2024
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13. Flurbiprofen in the subglottic space to prevent postoperative sore throat after cardiac surgery: A randomized double-blind study
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Calabrese, Maria, Arlotta, Gabriella, Antoniucci, Maria Enrica, Montini, Luca, Giannarelli, Diana, Taccheri, Temistocle, Corsi, Filippo, De Paulis, Stefano, Scapigliati, Andrea, Bevilacqua, Francesca, Vargas, Joel, Corrado, Michele, Pavone, Natalia, Bruno, Piergiorgio, Massetti, Massimo, and Cavaliere, Franco
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- 2024
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14. Is there a role for microbiome-based approach in common variable immunodeficiency?
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Poto, Remo, laniro, Gianluca, de Paulis, Amato, Spadaro, Giuseppe, Marone, Gianni, Gasbarrini, Antonio, and Varricchi, Gilda
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- 2023
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15. Pediatric Gaucher Disease Type 3 Presenting with Oculomotor Apraxia: A Case Report
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Margherita Di Costanzo, Nicoletta de Paulis, Giuseppe Cannalire, Nicola Morelli, and Giacomo Biasucci
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lysosomal storage disorder ,beta-glucocerebrosidase ,enzyme replacement therapy ,splenomegaly ,inherited metabolic diseases ,Pediatrics ,RJ1-570 - Abstract
We report on a 4-year-old boy affected by Gaucher disease (GD) type 3, who presented with splenomegaly and a history of oculomotor apraxia. GD is a rare lysosomal storage disorder caused by glucocerebrosidase deficiency with multi-organ involvement. Besides common clinical features such as hepatosplenomegaly and skeletal involvement, less frequent neurological symptoms, such as oculomotor apraxia, are indicative of neuronopathic forms of the disease, namely GD type 3, to be confirmed both by enzyme activity and genetic testing. Overall, GD management requires a multidisciplinary approach involving metabolic pediatricians, neurologists, psychologists, and geneticists, and currently relies on early enzyme replacement therapy. Although enzyme replacement therapy has proved to be effective in improving systemic signs and symptoms, it is unable to alleviate neurological complications once these have occurred, as it does not pass across the blood–brain barrier. Neurological improvements may occur through indirect mechanisms. Thus, our case report aims to highlight the importance of considering GD in the differential diagnosis of pediatric patients presenting with splenomegaly associated with neurological manifestations, as early intervention may significantly modify the disease progression and prevent further irreversible complications.
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- 2024
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16. Orbital/ocular inflammatory involvement in VEXAS syndrome: Data from the international AIDA network VEXAS registry
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Vitale, Antonio, Caggiano, Valeria, Martin-Nares, Eduardo, Frassi, Micol, Dagna, Lorenzo, Hissaria, Pravin, Sfriso, Paolo, Hernández-Rodríguez, José, Ruiz-Irastorza, Guillermo, Monti, Sara, Tufan, Abdurrahman, Piga, Matteo, Giardini, Henrique A Mayrink, Lopalco, Giuseppe, Viapiana, Ombretta, De Paulis, Amato, Triggianese, Paola, Vitetta, Rosetta, de-la-Torre, Alejandra, Fonollosa, Alex, Caroni, Federico, Sota, Jurgen, Conticini, Edoardo, Sbalchiero, Jessica, Renieri, Alessandra, Casamassima, Giulia, Wiesik-Szewczyk, Ewa, Yildirim, Derya, Hinojosa-Azaola, Andrea, Crisafulli, Francesca, Franceschini, Franco, Campochiaro, Corrado, Tomelleri, Alessandro, Callisto, Alicia, Beecher, Mark, Bindoli, Sara, Baggio, Chiara, Gómez-Caverzaschi, Verónica, Pelegrín, Laura, Soto-Peleteiro, Adriana, Milanesi, Alessandra, Vasi, Ibrahim, Cauli, Alberto, Antonelli, Isabele Parente de Brito, Iannone, Florenzo, Bixio, Riccardo, Casa, Francesca Della, Mormile, Ilaria, Gurnari, Carmelo, Fiorenza, Alessia, Mejia-Salgado, Germán, Kawakami-Campos, Perla Ayumi, Ragab, Gaafar, Ciccia, Francesco, Ruscitti, Piero, Bocchia, Monica, Balistreri, Alberto, Tosi, Gian Marco, Frediani, Bruno, Cantarini, Luca, and Fabiani, Claudia
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- 2024
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17. GPU accelerated digital twins of the human heart open new routes for cardiovascular research
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Viola, Francesco, Del Corso, Giulio, De Paulis, Ruggero, and Verzicco, Roberto
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- 2023
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18. Effects of COVID-19-targeted non-pharmaceutical interventions on pediatric hospital admissions in North Italian hospitals, 2017 to 2022: a quasi-experimental study interrupted time-series analysis
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Giuseppe Maglietta, Matteo Puntoni, Caterina Caminiti, Andrea Pession, Marcello Lanari, Fabio Caramelli, Federico Marchetti, Alessandro De Fanti, Lorenzo Iughetti, Giacomo Biasucci, Agnese Suppiej, Andrea Miceli, Chiara Ghizzi, Gianluca Vergine, Melodie Aricò, Marcello Stella, Susanna Esposito, Emilia-Romagna Paediatric COVID-19 network, Francesca Diodati, Chiara Maria Palo, Angela Miniaci, Luca Bertelli, Giovanni Biserni, Angela Troisi, Alessandra Iacono, Federico Bonvicini, Domenico Bartolomeo, Andrea Trombetta, Tommaso Zini, Nicoletta de Paulis, Cristina Forest, Battista Guidi, Francesca Di Florio, Enrico Valletta, Francesco Accomando, Greta Ramundo, Alberto Argentiero, Valentina Fainardi, and Michela Deolmi
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COVID-19 epidemiology ,non-pharmaceutical intervention (NPI) ,quasi-experimental design ,observational study ,Interrupted Time Series (ITS) regression analysis ,time series analysis ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe use of Non-Pharmaceutical Interventions (NPIs), such as lockdowns, social distancing and school closures, against the COVID-19 epidemic is debated, particularly for the possible negative effects on vulnerable populations, including children and adolescents. This study therefore aimed to quantify the impact of NPIs on the trend of pediatric hospitalizations during 2 years of pandemic compared to the previous 3 years, also considering two pandemic phases according to the type of adopted NPIs.MethodsThis is a multicenter, quasi-experimental before-after study conducted in 12 hospitals of the Emilia-Romagna Region, Northern Italy, with NPI implementation as the intervention event. The 3 years preceding the beginning of NPI implementation (in March 2020) constituted the pre-pandemic phase. The subsequent 2 years were further subdivided into a school closure phase (up to September 2020) and a subsequent mitigation measures phase with less stringent restrictions. School closure was chosen as delimitation as it particularly concerns young people. Interrupted Time Series (ITS) regression analysis was applied to calculate Hospitalization Rate Ratios (HRR) on the diagnostic categories exhibiting the greatest variation. ITS allows the estimation of changes attributable to an intervention, both in terms of immediate (level change) and sustained (slope change) effects, while accounting for pre-intervention secular trends.ResultsOverall, in the 60 months of the study there were 84,368 cases. Compared to the pre-pandemic years, statistically significant 35 and 19% decreases in hospitalizations were observed during school closure and in the following mitigation measures phase, respectively. The greatest reduction was recorded for “Respiratory Diseases,” whereas the “Mental Disorders” category exhibited a significant increase during mitigation measures. ITS analysis confirms a high reduction of level change during school closure for Respiratory Diseases (HRR 0.19, 95%CI 0.08–0.47) and a similar but smaller significant reduction when mitigation measures were enacted. Level change for Mental Disorders significantly decreased during school closure (HRR 0.50, 95%CI 0.30–0.82) but increased during mitigation measures by 28% (HRR 1.28, 95%CI 0.98–1.69).ConclusionOur findings provide information on the impact of COVID-19 NPIs which may inform public health policies in future health crises, plan effective control and preventative interventions and target resources where needed.
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- 2024
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19. Resumen: Consenso internacional para la nomenclatura y clasificación de la válvula aórtica bicúspide congénita y su aortopatía, con fines clínicos, quirúrgicos, intervencionistas y de investigación
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Hector I. Michelena, Alessandro della Corte, Arturo Evangelista, Joseph J. Maleszewski, William D. Edwards, Mary J. Roman, Richard B. Devereux, Borja Fernández, Federico M. Asch, Alex J. Barker, Lilia M. Sierra-Galán, Laurent de Kerchove, Susan M. Fernandes, Paul W.M. Fedak, Evaldas Girdauskas, Victoria Delgado, Suhny Abbara, Emmanuel Lansac, Siddharth K. Prakash, Malenka M. Bissell, Bogdan A. Popescu, Michael D. Hope, Marta Sitges, Vinod H. Thourani, Phillippe Pibarot, Krishnaswamy Chandrasekaran, Patrizio Lancellotti, Michael A. Borger, John K. Forrest, John Webb, Dianna M. Milewicz, Raj Makkar, Martin B. Leon, Stephen P. Sanders, Michael Markl, Victor A. Ferrari, William C. Roberts, Jae-Kwan Song, Philipp Blanke, Charles S. White, Samuel Siu, Lars G. Svensson, Alan C. Braverman, Joseph Bavaria, Thoralf M. Sundt, Gebrine El Khoury, Ruggero de Paulis, Maurice Enriquez-Sarano, Jeroen J. Bax, Catherine M. Otto, and Hans-Joachim Schäfers
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Válvula aórtica bicúspide. Aortopatía. Nomenclatura. Clasificación. VAB. Válvula aórtica bivalva. ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Este consenso de nomenclatura y clasificación para la válvula aórtica bicúspide congénita y su aortopatía está basado en la evidencia y destinado a ser utilizado universalmente por médicos (tanto pediatras como de adultos), médicos ecocardiografistas, especialistas en imágenes avanzadas cardiovasculares, cardiólogos intervencionistas, cirujanos cardiovasculares, patólogos, genetistas e investigadores que abarcan estas áreas de investigación clínica y básica. Siempre y cuando se disponga de nueva investigación clave y de referencia, este consenso internacional puede estar sujeto a cambios de acuerdo con datos basados en la evidencia1.
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- 2024
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20. Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
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Modestino, Luca, Cristinziano, Leonardo, Trocchia, Marialuisa, Ventrici, Annagioia, Capone, Mariaelena, Madonna, Gabriele, Loffredo, Stefania, Ferrara, Anne Lise, Romanelli, Marilena, Simeone, Ester, Varricchi, Gilda, Rossi, Francesca Wanda, de Paulis, Amato, Marone, Gianni, Ascierto, Paolo Antonio, and Galdiero, Maria Rosaria
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- 2023
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21. Truncating variants in the penultimate exon of TGFBR1 escaping nonsense-mediated mRNA decay cause Loeys-Dietz syndrome
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Fortugno, Paola, Monetta, Rosanna, Cinquina, Valeria, Rigon, Chiara, Boaretto, Francesca, De Luca, Chiara, Zoppi, Nicoletta, Di Leandro, Luana, De Domenico, Emanuela, Di Daniele, Arianna, Ippoliti, Rodolfo, Angelucci, Francesco, Di Cesare, Ernesto, De Paulis, Ruggero, Salviati, Leonardo, Colombi, Marina, Brancati, Francesco, and Ritelli, Marco
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- 2023
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22. Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC)
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Marco Caminati, Luisa Brussino, Matilde Carlucci, Palma Carlucci, Lucia Federica Carpagnano, Cristiano Caruso, Lorenzo Cosmi, Simona D’Amore, Stefano Del Giacco, Aikaterini Detoraki, Mario Di Gioacchino, Andrea Matucci, Ilaria Mormile, Francescopaolo Granata, Gabriella Guarnieri, Mauro Krampera, Matteo Maule, Eustachio Nettis, Stefania Nicola, Silvia Noviello, Fabrizio Pane, Cristina Papayannidis, Paola Parronchi, Girolamo Pelaia, Erminia Ridolo, Francesca Wanda Rossi, Gianenrico Senna, Massimo Triggiani, Angelo Vacca, Emanuele Vivarelli, Alessandra Vultaggio, and Amato de Paulis
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eosinophils ,hypereosinophilia ,hypereosinophilic syndrome ,mepolizumab ,management ,network ,Cytology ,QH573-671 - Abstract
Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective burden of non-malignant HES and, more in general, HE disorders is currently unknown. On a practical note, shortening the diagnostic delay and the time to an appropriate treatment approach probably represents the most urgent issue, even in light of the great impact of HES on the quality of life of affected patients. The present document represents the first action that the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) has finalized within a wider project aiming to establish a collaborative national network on HES (InHES—Italian Network on HES) for patients and physicians. The first step of the project could not but focus on defining a common language as well as sharing with all of the medical community an update on the most recent advances in the field. In fact, the existing literature has been carefully reviewed in order to critically integrate the different views on the topic and derive practical recommendations on disease identification and treatment approaches.
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- 2024
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23. GPU accelerated digital twins of the human heart open new routes for cardiovascular research
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Francesco Viola, Giulio Del Corso, Ruggero De Paulis, and Roberto Verzicco
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Medicine ,Science - Abstract
Abstract The recruitment of patients for rare or complex cardiovascular diseases is a bottleneck for clinical trials and digital twins of the human heart have recently been proposed as a viable alternative. In this paper we present an unprecedented cardiovascular computer model which, relying on the latest GPU-acceleration technologies, replicates the full multi-physics dynamics of the human heart within a few hours per heartbeat. This opens the way to extensive simulation campaigns to study the response of synthetic cohorts of patients to cardiovascular disorders, novel prosthetic devices or surgical procedures. As a proof-of-concept we show the results obtained for left bundle branch block disorder and the subsequent cardiac resynchronization obtained by pacemaker implantation. The in-silico results closely match those obtained in clinical practice, confirming the reliability of the method. This innovative approach makes possible a systematic use of digital twins in cardiovascular research, thus reducing the need of real patients with their economical and ethical implications. This study is a major step towards in-silico clinical trials in the era of digital medicine.
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- 2023
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24. Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review
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Gaudino, Mario, Di Franco, Antonino, Arbustini, Eloisa, Bacha, Emile, Bates, Eric R., Cameron, Duke E., Cao, Davide, David, Tirone E., De Paulis, Ruggero, El-Hamamsy, Ismail, Farooqi, Kanwal M., Girardi, Leonard N., Gräni, Christoph, Kochav, Jonathan D., Molossi, Silvana, Puskas, John D., Rao, Sunil V., Sandner, Sigrid, Tatoulis, James, Truong, Quynh A., Weinsaft, Jonathan W., Zimpfer, Daniel, and Mery, Carlos M.
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- 2023
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25. Application of an integrated RNN - ensemble method for the short-term forecast of inter-area oscillations modal parameters
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Olivieri, Carlo, de Paulis, Francesco, Orlandi, Antonio, Pisani, Cosimo, Tessitore, Salvatore, and Giannuzzi, Giorgio
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- 2023
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26. A sign in space: An interdisciplinary exploration of the potential reception of an extraterrestrial signal
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de Paulis, Daniela, Ferri, Paolo, Shostak, Seth, Estévez, Daniel, Montebugnoli, Stelio, Bianchi, Germano, Melis, Andrea, and Scuka, Daniel
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- 2023
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27. ACC/AHA and ESC/EACTS Guidelines for the Management of Valvular Heart Diseases: JACC Guideline Comparison
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Coisne, Augustin, Lancellotti, Patrizio, Habib, Gilbert, Garbi, Madalina, Dahl, Jordi Sanchez, Barbanti, Marco, Vannan, Mani A., Vassiliou, Vassilios S., Dudek, Dariusz, Chioncel, Ovidiu, Waltenberger, Johannes L., Johnson, Victoria L., De Paulis, Ruggero, Citro, Rodolfo, and Pibarot, Philippe
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- 2023
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28. Embodiment in Space Imagery
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de Paulis, Daniela, primary and Haramia, Chelsea, additional
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- 2023
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29. The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities
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Filomena Napolitano, Francesca Wanda Rossi, Amato de Paulis, Antonio Lavecchia, and Nunzia Montuori
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systemic sclerosis ,urokinase receptor ,N-formyl peptide receptors ,fibroblast proliferation ,small molecules ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Systemic Sclerosis (SSc) is a heterogeneous autoimmune disease characterized by widespread vasculopathy, the presence of autoantibodies and the progressive fibrosis of skin and visceral organs. There are still many questions about its pathogenesis, particularly related to the complex regulation of the fibrotic process, and to the factors that trigger its onset. Our recent studies supported a key role of N-formyl peptide receptors (FPRs) and their crosstalk with uPAR in the fibrotic phase of the disease. Here, we found that dermal fibroblasts acquire a proliferative phenotype after the activation of FPRs and their interaction with uPAR, leading to both Rac1 and ERK activation, c-Myc phosphorylation and Cyclin D1 upregulation which drive cell cycle progression. The comparison between normal and SSc fibroblasts reveals that SSc fibroblasts exhibit a higher proliferative rate than healthy control, suggesting that an altered fibroblast proliferation could contribute to the initiation and progression of the fibrotic process. Finally, a synthetic compound targeting the FPRs/uPAR interaction significantly inhibits SSc fibroblast proliferation, paving the way for the development of new targeted therapies in fibrotic diseases.
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- 2024
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30. Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry
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Micol Frassi, Marcello Govoni, Annamaria Iagnocco, Florenzo Iannone, Paola Triggianese, Corrado Campochiaro, Sara Monti, Maria G Tektonidou, Eduardo Martin-Nares, Piero Ruscitti, Roberto Giacomelli, Luca Cantarini, Giuseppe Lopalco, Lorenzo Dagna, Francesco Carubbi, Alma Nunzia Olivieri, Antonio Vitale, Ombretta Viapiana, Fatma Alibaz-Öner, Haner Direskeneli, Petros P Sfikakis, Giacomo Emmi, Claudia Fabiani, Gabriele Simonini, Francesco Ciccia, Elena Bartoloni, Alessandro Tomelleri, Daniela Iacono, Riza Can Kardas, Bruno Frediani, Benson Ogunjimi, Amato de Paulis, Onorina Berardicurti, Alessandro Conforti, Ilenia Di Cola, Anastasios Karamanakos, Katerina Laskari, Abdurrahman Tufan, Stefania Costi, José Hernández-Rodríguez, Lampros Fotis, Jurgen Sota, Antonio Gidaro, Ewa Wiesik-Szewczyk, Gian Domenico Sebastiani, Jiram Torres-Ruiz, Paolo Sfriso, Giovanni Conti, Luca Navarini, Francesco La Torre, Samar Tharwat, Andrea Hinojosa-Azaola, Alberto Lo Gullo, Valeria Caggiano, Ibrahim A Almaghlouth, Kazi Asfina, Gafaar Ragab, Maria Cristina Maggio, Joanna Makowska, Emanuela Del Giudice, Armin Maier, Sukran Erten, Henrique A Mayrink Giardini, Maria Morrone, Isabele Parente de Brito Antonelli, Marilia Ambiel Dagostin, Martina Patrone, Fehaid Alanazi, Carla Gaggiano, Hamit Kucuk, Ayman Abdel-Monem Ahmed Mahmoud, Katerina Kourtesi, Maria Tarsia, Verónica Gómez-Caverzaschi, Angela Mauro, and Alberto Balistreri
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Medicine - Abstract
Objective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still’s disease.Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still’s disease.Results A total of 411 patients suffering from Still’s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still’s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p
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- 2023
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31. Aortic root anatomy after aortic valve reimplantation
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Irace, Francesco Giosuè, Chirichilli, Ilaria, Salica, Andrea, D'Aleo, Salvatore, Guerrieri Wolf, Lorenzo, Garufi, Luigi, and De Paulis, Ruggero
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- 2023
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32. Mare Incognito.
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Daniela de Paulis
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- 2023
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33. A patient-driven registry on Behçet’s disease: the AIDA for patients pilot project
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Carla Gaggiano, Alessandra Del Bianco, Jurgen Sota, Stefano Gentileschi, Piero Ruscitti, Roberto Giacomelli, Matteo Piga, Francesca Crisafulli, Sara Monti, Giacomo Emmi, Amato De Paulis, Antonio Vitale, Maria Tarsia, Valeria Caggiano, Rossana Nuzzolese, Veronica Parretti, Claudia Fabiani, Giuseppe Lopalco, Armin Maier, Marco Cattalini, Donato Rigante, Marcello Govoni, Francesca Li Gobbi, Serena Guiducci, Paola Parronchi, Achille Marino, Francesco Ciccia, Maria Cristina Maggio, Emma Aragona, Elena Bartoloni, Annamaria Iagnocco, Ombretta Viapiana, Gian Domenico Sebastiani, Silvana Guerriero, Antonella Insalaco, Emanuela Del Giudice, Giovanni Conti, Patrizia Barone, Alma Nunzia Olivieri, Antonio Brucato, Francesco Carubbi, Paola Triggianese, Angela Mauro, Gian Marco Tosi, Alex Fonollosa, Henrique Ayres Mayrink Giardini, Gaafar Ragab, Samar Tharwat, José Hernández-Rodríguez, Petros P. Sfikakis, Katerina Laskari, Anastasios Karamanakos, Gerard Espinosa, Farhad Shahram, Haner Direskeneli, Andrea Hinojosa-Azaola, Daniela Opris-Belinski, Ibrahim A. AlMaghlouth, Gülen Hatemi, Mehmet Akif Eksin, Fatos Önen, Ewa Więsik-Szewczyk, Nurullah Akkoç, Abdurrahman Tufan, Ali Şahin, Şükran Erten, Seza Ozen, Ezgi Deniz Batu, Bruno Frediani, Alberto Balistreri, and Luca Cantarini
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Behçet’s disease ,patient-driven registries ,rare diseases ,autoinflammatory diseases ,patient involvement ,patient-reported outcomes ,Medicine (General) ,R5-920 - Abstract
IntroductionThis paper describes the creation and preliminary results of a patient-driven registry for the collection of patient-reported outcomes (PROs) and patient-reported experiences (PREs) in Behçet’s disease (BD).MethodsThe project was coordinated by the University of Siena and the Italian patient advocacy organization SIMBA (Associazione Italiana Sindrome e Malattia di Behçet), in the context of the AIDA (AutoInflammatory Diseases Alliance) Network programme. Quality of life, fatigue, socioeconomic impact of the disease and therapeutic adherence were selected as core domains to include in the registry.ResultsRespondents were reached via SIMBA communication channels in 167 cases (83.5%) and the AIDA Network affiliated clinical centers in 33 cases (16.5%). The median value of the Behçet’s Disease Quality of Life (BDQoL) score was 14 (IQR 11, range 0–30), indicating a medium quality of life, and the median Global Fatigue Index (GFI) was 38.7 (IQR 10.9, range 1–50), expressing a significant level of fatigue. The mean Beliefs about Medicines Questionnaire (BMQ) necessity-concern differential was 0.9 ± 1.1 (range – 1.8–4), showing that the registry participants prioritized necessity belief over concerns to a limited extent. As for the socioeconomic impact of BD, in 104 out of 187 cases (55.6%), patients had to pay from their own pocket for medical exams required to reach the diagnosis. The low family socioeconomic status (p
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- 2023
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34. Basophils beyond allergic and parasitic diseases
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Remo Poto, Stefania Loffredo, Gianni Marone, Antonio Di Salvatore, Amato de Paulis, John T. Schroeder, and Gilda Varricchi
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alarmins ,allergy ,autoimmunity ,basophil ,cancer ,COVID-19, myocardial infarction ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease. This fundamental similarity, along with some morphological features shared by the two cell types, has long brought into question the biological significance that basophils mediate beyond that of mast cells. Unlike mast cells, which mature and reside in tissues, basophils are released into circulation from the bone marrow (constituting 1% of leukocytes), only to infiltrate tissues under specific inflammatory conditions. Evidence is emerging that basophils mediate non-redundant roles in allergic disease and, unsuspectingly, are implicated in a variety of other pathologies [e.g., myocardial infarction, autoimmunity, chronic obstructive pulmonary disease, fibrosis, cancer, etc.]. Recent findings strengthen the notion that these cells mediate protection from parasitic infections, whereas related studies implicate basophils promoting wound healing. Central to these functions is the substantial evidence that human and mouse basophils are increasingly implicated as important sources of IL-4 and IL-13. Nonetheless, much remains unclear regarding the role of basophils in pathology vs. homeostasis. In this review, we discuss the dichotomous (protective and/or harmful) roles of basophils in a wide spectrum of non-allergic disorders.
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- 2023
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35. Time Domain Assessment of Minimum FEXT by Tabbed Line Design
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de Paulis, Francesco, primary, Olivieri, Carlo, additional, and Pali, Alessandro, additional
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- 2024
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36. Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries
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Vitale, Antonio, primary, Caggiano, Valeria, additional, Tufan, Abdurrahman, additional, Ragab, Gaafar, additional, Batu, Ezgi Deniz, additional, Portincasa, Piero, additional, Aragona, Emma, additional, Sota, Jurgen, additional, Conti, Giovanni, additional, De Paulis, Amato, additional, Rigante, Donato, additional, Olivieri, Alma Nunzia, additional, Şahin, Ali, additional, La Torre, Francesco, additional, Lopalco, Giuseppe, additional, Cattalini, Marco, additional, Maggio, Maria Cristina, additional, Insalaco, Antonella, additional, Sfikakis, Petros P., additional, Verrecchia, Elena, additional, Yildirim, Derya, additional, Kucuk, Hamit, additional, Kardas, Riza Can, additional, Laymouna, Ahmed Hatem, additional, Ghanema, Mahmoud, additional, Saad, Moustafa Ali, additional, Sener, Seher, additional, Ercan Emreol, Hulya, additional, Ozen, Seza, additional, Jaber, Nour, additional, Khalil, Mohamad, additional, Di Ciaula, Agostino, additional, Gaggiano, Carla, additional, Malizia, Giuseppe, additional, Affronti, Andrea, additional, Patroniti, Serena, additional, Romeo, Meri, additional, Sbalchiero, Jessica, additional, Della Casa, Francesca, additional, Mormile, Ilaria, additional, Silvaroli, Sara, additional, Gicchino, Maria Francesca, additional, Çelik, Neşe Çabuk, additional, Tarsia, Maria, additional, Karamanakos, Anastasios, additional, Hernández-Rodríguez, José, additional, Parronchi, Paola, additional, Opris-Belinski, Daniela, additional, Barone, Patrizia, additional, Recke, Andreas, additional, Costi, Stefania, additional, Sfriso, Paolo, additional, Giardini, Henrique A. Mayrink, additional, Gentileschi, Stefano, additional, Wiesik-Szewczyk, Ewa, additional, Vasi, Ibrahim, additional, Loconte, Roberta, additional, Jahnz-Różyk, Karina, additional, Martín-Nares, Eduardo, additional, Torres-Ruiz, Jiram, additional, Cauli, Alberto, additional, Conforti, Alessandro, additional, Emmi, Giacomo, additional, Li Gobbi, Francesca, additional, Biasi, Giovanni Rosario, additional, Terribili, Riccardo, additional, Ruscitti, Piero, additional, Del Giudice, Emanuela, additional, Tharwat, Samar, additional, Brucato, Antonio Luca, additional, Ogunjimi, Benson, additional, Hinojosa-Azaola, Andrea, additional, Balistreri, Alberto, additional, Fabiani, Claudia, additional, Frediani, Bruno, additional, and Cantarini, Luca, additional
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- 2024
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37. Correction to: Is there a role for microbiome‑based approach in common variable immunodeficiency?
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Poto, Remo, Ianiro, Gianluca, de Paulis, Amato, Spadaro, Giuseppe, Marone, Gianni, Gasbarrini, Antonio, and Varricchi, Gilda
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- 2023
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38. Future Needs in Mast Cell Biology.
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Varricchi, Gilda, de Paulis, Amato, Marone, Gianni, and Galli, Stephen J
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Mast Cells ,Animals ,Humans ,Disease Susceptibility ,Cell Movement ,Homeostasis ,Cell Physiological Phenomena ,Biomarkers ,allergy ,atherosclerosis ,cancer ,cancer-related inflammation ,mast cell ,myocardial infarction ,predictive biomarker ,tumor-associated mast cells ,Other Chemical Sciences ,Genetics ,Other Biological Sciences ,Chemical Physics - Abstract
The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small number of biochemical characteristics. More recently, "subtypes" of mast cells have been described based on the analysis of transcriptomes of anatomically distinct mouse mast cell populations. Although mast cells can potently alter homeostasis, in certain circumstances, these cells can also contribute to the restoration of homeostasis. Both solid and hematologic tumors are associated with the accumulation of peritumoral and/or intratumoral mast cells, suggesting that these cells can help to promote and/or limit tumorigenesis. We suggest that at least two major subsets of mast cells, MC1 (meaning anti-tumorigenic) and MC2 (meaning pro-tumorigenic), and/or different mast cell mediators derived from otherwise similar cells, could play distinct or even opposite roles in tumorigenesis. Mast cells are also strategically located in the human myocardium, in atherosclerotic plaques, in close proximity to nerves and in the aortic valve. Recent studies have revealed evidence that cardiac mast cells can participate both in physiological and pathological processes in the heart. It seems likely that different subsets of mast cells, like those of cardiac macrophages, can exert distinct, even opposite, effects in different pathophysiological processes in the heart. In this chapter, we have commented on possible future needs of the ongoing efforts to identify the diverse functions of mast cells in health and disease.
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- 2019
39. Passive Intermodulation Measurement: Challenges and Solutions
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Zhanghua Cai, Lie Liu, Francesco de Paulis, and Yihong Qi
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Passive intermodulation (PIM) ,PIM source location ,Anechoic chamber ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
In modern wireless communication systems, the signal-to-noise ratio (SNR) is one of the most important performance indicators. When the other radio frequency (RF) performance of the components is well designed, passive intermodulation (PIM) interference may become an important factor limiting the system’s SNR. Whether it is a base station, an indoor distributed antenna system, or a satellite system, there are stringent PIM level requirements to minimize interference and enhance network capacity in multicarrier networks. Especially for systems of high power and wide bandwidth such as 5G wireless communication, PIM interference is even more serious. Due to the complexity and uncertainty of PIM, measurement is the most important means to study and evaluate the PIM performance of wireless communication systems. In this review, the current main PIM measurement methods recommended by International Electrotechnical Commission (IEC) and other standard organizations are introduced, and several key challenges in PIM measurement and their solutions (including the design of PIM tester, the location of the PIM sources, the design of compact PIM anechoic chambers, and the evaluation methods of PIM anechoic chambers) are highlighted. These challenges are of great significance to solve PIM problems that may arise during device characterization and verification in real wireless communication systems.
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- 2022
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40. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life
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Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio, Amato De Paulis, Giuseppe Spadaro, Danilo Di Bona, Angela Maria D’Uggento, Lia Ginaldi, Francesco Gaeta, Eleonora Nucera, Kliljeda Jaubashi, Danilo Villalta, Lorenzo Dagna, Domenico Ciotta, Francesco Pucciarini, Diego Bagnasco, Giorgio Celi, Fulvia Chieco Bianchi, Lorenzo Cosmi, Maria Teresa Costantino, Maria Angiola Crivellaro, Simona D’Alò, Pietro del Biondo, Stefano Del Giacco, Mario Di Gioacchino, Linda Di Pietro, Elisabetta Favero, Sebastiano Gangemi, Gabriella Guarnieri, Enrico Heffler, Maria Stefania Leto Barone, Carla Lombardo, Francesca Losa, Andrea Matucci, Paola Lucia Minciullo, Paola Parronchi, Giovanni Passalacqua, Stefano Pucci, Oliviero Rossi, Lorenzo Salvati, Michele Schiappoli, Gianenrico Senna, Andrea Vianello, Alessandra Vultaggio, Yang Baoran, Cristoforo Incorvaia, and Giorgio Walter Canonica
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Aim of the study was to evaluate the efficacy and safety of dupilumab in adult patients with CRSwNP stratified by common overlapping comorbid conditions. Methods We performed a multicenter, observational, prospective study enrolling adult patients with severe CRSwNP who had started dupilumab treatment in the context of standard care from January 2021 to October 2021. Data were collected from twentynine Italian secondary care centers for allergy and clinical immunology, all of which were part of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). A number of efficacy parameters were used. Patient data were compared using the Wilcoxon test for paired data. All statistical analyses were performed with SPSS version 20 (IBM, Armonk, NY, USA). Results In total, 82 patients with nasal polyposis were identified. A significant improvement was detected for all the applied efficacy parameters, i.e. 22-item Sino-Nasal Outcome Test (SNOT-22) and bilateral endoscopic nasal polyp score (NPS) scores for CRSwNP, Rhinitis Control Scoring System (RCSS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores for allergic perennial rhinitis, Forced Expiratory Volume in the 1st second (FEV1) and Asthma Quality of Life Questionnaire (AQLQ) scores for asthma, Eczema Area and Severity Index (EASI) and Dermatology Life Quality Index (DLQI) scores for AD. A non-significant improvement was also obtained in the Urticaria Activity Score over 7 days (UAS7) for chronic spontaneous urticaria. Treatment with dupilumab was well tolerated. Conclusions These data suggest that dupilumab treatment in patients suffering from CRSwNP and associated comorbidities may be suitable. Such outcome, although confirmation by trials is warranted, suggests the possibility to treat different disorders with a single therapy, with favorable effects especially under the cost-effectiveness aspect.
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- 2022
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41. An 1.7–2.7 GHz all-weather broadband High-gain antenna with W-shape reflector for maritime communications
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Weng, Zibin, Chi, Lidong, Drewniak, James L., de Paulis, Francesco, Zhu, Yu, and Qi, Yihong
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- 2022
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42. Reimplantation versus aortic ring annuloplasty in bicuspid valve with borderline aortic root ectasia
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Irace, Francesco Giosuè, Chirichilli, Ilaria, Folino, Giulio, Salica, Andrea, Guerrieri Wolf, Lorenzo, Scaffa, Raffaele, D'Aleo, Salvatore, Weltert, Luca Paolo, and De Paulis, Ruggero
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- 2022
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43. Bioprosthetic Aortic Valve Hemodynamics: Definitions, Outcomes, and Evidence Gaps: JACC State-of-the-Art Review
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Herrmann, Howard C., Pibarot, Philippe, Wu, Changfu, Hahn, Rebecca T., Tang, Gilbert H.L., Abbas, Amr E., Playford, David, Ruel, Marc, Jilaihawi, Hasan, Sathananthan, Janarthanan, Wood, David A., De Paulis, Ruggero, Bax, Jeroen J., Rodes-Cabau, Josep, Cameron, Duke E., Chen, Tiffany, Del Nido, Pedro J., Dweck, Marc R., Kaneko, Tsuyoshi, Latib, Azeem, Moat, Neil, Modine, Thomas, Popma, Jeffrey J., Raben, Jamie, Smith, Robert L., Tchetche, Didier, Thomas, Martyn R., Vincent, Flavien, Yoganathan, Ajit, Zuckerman, Bram, Mack, Michael J., and Leon, Martin B.
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- 2022
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44. Rheumatoid arthritis and osteogenesis imperfecta: is there a genetic causal association?
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Mormile, Ilaria, Russo, Roberta, Andolfo, Immacolata, de Paulis, Amato, Rossi, Francesca Wanda, and Rendina, Domenico
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- 2022
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45. Passive Intermodulation Measurement: Challenges and Solutions
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Cai, Zhanghua, Liu, Lie, de Paulis, Francesco, and Qi, Yihong
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- 2022
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46. Loop Antennas for Accurate Calibration of OTA Measurement Systems: Review, Challenges, and Solutions.
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Yuming Zheng, Bin Lin 0001, Francesco de Paulis, Mike Violette, Xiaoning Ye, and Yihong Qi
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- 2022
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47. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life
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Nettis, Eustachio, Brussino, Luisa, Patella, Vincenzo, Bonzano, Laura, Detoraki, Aikaterini, Di Leo, Elisabetta, Sirufo, Maria Maddalena, Caruso, Cristiano, Lodi Rizzini, Fabio, Conte, Mariaelisabetta, Yacoub, Mona-Rita, Triggiani, Massimo, Ridolo, Erminia, Macchia, Luigi, Rolla, Giovanni, Brancaccio, Raffaele, De Paulis, Amato, Spadaro, Giuseppe, Di Bona, Danilo, D’Uggento, Angela Maria, Ginaldi, Lia, Gaeta, Francesco, Nucera, Eleonora, Jaubashi, Kliljeda, Villalta, Danilo, Dagna, Lorenzo, Ciotta, Domenico, Pucciarini, Francesco, Bagnasco, Diego, Celi, Giorgio, Chieco Bianchi, Fulvia, Cosmi, Lorenzo, Costantino, Maria Teresa, Crivellaro, Maria Angiola, D’Alò, Simona, del Biondo, Pietro, Del Giacco, Stefano, Di Gioacchino, Mario, Di Pietro, Linda, Favero, Elisabetta, Gangemi, Sebastiano, Guarnieri, Gabriella, Heffler, Enrico, Leto Barone, Maria Stefania, Lombardo, Carla, Losa, Francesca, Matucci, Andrea, Minciullo, Paola Lucia, Parronchi, Paola, Passalacqua, Giovanni, Pucci, Stefano, Rossi, Oliviero, Salvati, Lorenzo, Schiappoli, Michele, Senna, Gianenrico, Vianello, Andrea, Vultaggio, Alessandra, Baoran, Yang, Incorvaia, Cristoforo, and Canonica, Giorgio Walter
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- 2022
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48. Fish Roe-Induced Anaphylaxis in Italy: A Pediatric Case Report
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Nicoletta De Paulis, Margherita Di Costanzo, Maria Elena Capra, Silvia Peveri, Marcello Montagni, and Giacomo Biasucci
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fish roe ,salmon roe ,lumpfish roe ,anaphylaxis ,child ,food allergy ,Medicine ,Pediatrics ,RJ1-570 - Abstract
Fish roe are not yet described as triggers of allergic reactions in Italy, especially during the pediatric age; they are more frequently involved in anaphylaxis in Eastern countries, such as Japan. For this report, we reported a case of anaphylaxis in a 2-year-old boy admitted to our Hospital Pediatric Emergency Room with a suspected allergic reaction. 15 min after the meal, he presented generalized urticaria, angioedema, wheezing, sneezing, and two vomiting episodes. The meal was smoked salmon, butter, mayonnaise, anchovies, and fish roe (salmon and lumpfish roe). Tryptase serum levels presented as elevated in the acute phase and normal after 24 h. Serum food-specific IgE tested negative for salmon and other fish, such as skin prick tests. Serum food-specific IgE showed that the patient was sensitized to cow’s milk and eggs, but he doesn’t have a food allergy. He had regularly consumed milk and eggs before and after the allergic reaction without clinical problems. A prick-by-prick test resulted positive for fish roe (salmon and lumpfish roe). Based on patient’s history, allergy test results in vivo, and tryptase serum levels, the diagnosis of anaphylaxis induced by fish roe was confirmed. In conclusion, to the best of our knowledge, this is the first pediatric case of fish roe-induced anaphylaxis reported in Italy.
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- 2022
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49. Calibration loop antenna for 5G OTA measurement systems
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Zheng, Yuming, Lin, Bin, Wu, Jiyu, de Paulis, Francesco, Liu, Lie, and Qi, Yihong
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- 2022
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50. Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients.
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Modestino, Luca, Tumminelli, Manuela, Mormile, Ilaria, Cristinziano, Leonardo, Ventrici, Annagioia, Trocchia, Marialuisa, Ferrara, Anne Lise, Palestra, Francesco, Loffredo, Stefania, Marone, Gianni, Rossi, Francesca Wanda, de Paulis, Amato, and Galdiero, Maria Rosaria
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LEUCOCYTES ,TUMOR necrosis factors ,INTERLEUKIN-17 ,REACTIVE oxygen species ,BLOOD serum analysis ,PSORIATIC arthritis - Abstract
Background: Neutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and are among the main actors in the inflammatory response. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting both the axial and peripheral joints. Typically associated with psoriasis, PsA can also affect multiple systems and organs, including the nails and entheses. Despite the involvement of PMNs in PsA, their specific role in the disease remains poorly understood. This study aimed to characterize the biological functions of PMNs and neutrophil-related mediators in PsA patients. Materials and methods: 31 PsA patients and 22 healthy controls (HCs) were prospectively recruited. PMNs were isolated from peripheral blood and subjected to in vitro stimulation with lipopolysaccharide (LPS), N-Formylmethionyl-leucylphenylalanine (fMLP), tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate (PMA), or control medium. Highly purified peripheral blood PMNs (>99%) were evaluated for activation status, reactive oxygen species (ROS) production, phagocytic activity, granular enzyme and neutrophil extracellular traps (NETs) release. Serum levels of matrix metalloproteinase-9 (MMP-9), myeloperoxidase (MPO), TNF, interleukin 23 (IL-23), and interleukin 17 (IL-17) were measured by ELISA. Serum Citrullinated histone H3 (CitH3) was measured as a NET biomarker. Results: Activated PMNs from PsA patients displayed reduced activation, decreased ROS production, and impaired phagocytic activity upon stimulation with TNF, compared to HCs. PMNs from PsA patients also displayed reduced granular enzyme (MPO) and NET release. Serum analyses revealed elevated levels of MMP-9, MPO, TNF, IL-23, IL-17, and CitH3 in PsA patients compared to HCs. Serum CitH3 levels positively correlated with MPO and TNF concentrations, and IL-17 concentrations were positively correlated with IL-23 levels in PsA patients. These findings indicate that PMNs from PsA patients show reduced in vitro activation and function, and an increased presence of neutrophil-derivedmediators (MMP-9, MPO, TNF, IL-23, IL-17, and CitH3) in their serum. Conclusions: Taken together, our findings suggest that PMNs from PsA patients exhibit an "exhausted" phenotype, highlighting their plasticity and multifaceted roles in PsA pathophysiology. [ABSTRACT FROM AUTHOR]
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- 2024
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