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A programação paralela apesar de ser uma realidade nos grandes centros de pesquisa ainda apresenta um grande descompasso com relação ao ensino nos cursos de graduação em Computação. E essa diferença se apresenta ainda mais visível quando a programação paralela é apresentada com as placas gráficas, pois os desafios impostos ao ensino do pensamento paralelo se mostram ainda mais complexos. Este trabalho apresenta um mapeamento sistemático das metodologias e ferramentas utilizadas no processo de ensino-aprendizagem da programação paralela com placas gráficas. As metodologias apontadas nos cinco estudos selecionados vão desde o ensino tradicional com aulas expositivas até o uso de didáticas sem o uso do computador.

Una de las estrategias del proyecto W-STEM para mejorar la participación de las mujeres los programas STEM es realizar un acompañamiento a las estudiantes desde que inician su carrera. La UTB cuenta con un programa de mentorías llamado “Tepaya” que ofrece acompañamiento a todos los estudiantes de primer semestre. Este programa es dirigido por el departamento de bienestar universitario ECO. Sin embargo, no tiene una orientación hacia el empoderamiento de la mujer en las carreras STEM. Por lo tanto, el equipo W-STEM decidió desarrollar un piloto de mentorías propio para la Facultad de Ingenierías, con perspectiva de género para acompañar las estudiantes en su primer año de estudio., The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

En el Centro Universitario de Ciencias Exactas e Ingenierías de la Universidad de Guadalajara, se ha desarrollado un programa de atracción a través de mentorías con perspectiva de género dentro del proyecto europeo W-STEM. Este programa de mentorías está ligado al programa global denominado Technovation Girls en donde jóvenes mentoras guían a equipos de mujeres más jóvenes con el objetivo de resolver un problema de su entorno a partir de una aplicación móvil. Es de gran relevancia que el rol model sea representado por y para mujeres jóvenes, ya que, las personas buscan otras con algunas similitudes que puedan ser fuente de inspiración para la superación personal., The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Juan Wei,1,2 Hanfeng Xu,2 Wei Wei,3 ZhaoJing Wang,4 QiJia Zhang,2 Wei De,5 Yongqian Shu1 1Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Department of Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 3Department of Gastrosurgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, People’s Republic of China; 4Department of Digestive Oncology Surgery, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 5Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Yongqian ShuDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaEmail yongqian_shu@126.com Wei DeDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaEmail dewei_njmu@sina.comBackground: Circular RNAs (circRNAs) play important regulatory roles in cancer development. However, the mechanisms by which circRNAs regulate gene expression in gastric cancer (GC) remain unclear.Methods: Human GC samples and their matched normal adjacent tissues were obtained from 30 patients to assess the expression of circHIPK3 and its relationship with GC proliferation and migration. A series of in vitro and in vivo functional experiments were carried out to elucidate the role of circHIPK3 in GC proliferation and migration, and its underlying molecular mechanisms.Results: Using a circRNA microarray we found a circRNA termed circHIPK3 that performed a significant regulatory role in GC. circHIPK3 was further confirmed to be upregulated in all GC tissues and cells tested. Furthermore, circHIPK3 levels were associated with Tumor & Lymph Node & Metastasis(TNM) stage (P = 0.032). The area under the receiver operating characteristic curve (ROC) was 0.743 (95% confidence interval 0.615– 0.872; P = 0.001). CCK-8, colony formation, Transwell and EdU assays were performed to evaluate the effects of circHIPK3 on cell proliferation and migration in GC. Moreover, circHIPK3 was identified as a sponge of miR-107, and as such it regulated brain-derived neurotrophic factor (BDNF), which plays a pivotal role in the development of GC.Conclusion: circHIPK3 represents a novel potential biomarker and therapeutic target of GC.Keywords: circHIPK3, miR-107, BDNF, proliferation, migration, gastric cancer

De huidige agrarische studenten op mbo en hbo zijn degenen die als ondernemer of adviseur direct invloed uitoefenen op het grasland en de melkveehouderij in de komende 30-40 jaar. Maar hoe kijken zij eigenlijk tegen grasland en beweiding aan? En is dat in de laatste jaren veranderd? In de zomer van 2016, 2018 en 2020 is een grootschalige enquête afgenomen onder studenten van het mbo en hbo in het groene onderwijs. De enquête genaamd ‘Wat vind JIJ van grasland en beweiding?’ richtte zich op de waarde van verschillende thema’s rondom grasland en beweiding en de inhoud van beweidingslessen. De studenten konden aangeven in welke mate ze een thema belangrijk vonden, wat ze geleerd hebben in de beweidingslessen en over welke onderwerpen zij graag meer willen leren. Door dit onderzoek is het voor het eerst mogelijk geworden om het denken over grasland en beweiding bij agrarische studenten meetbaar te maken. Daarnaast is het inzicht uit deze enquêtes gebruikt om het onderwijs over grasland en beweiding te actualiseren.

Objective: This study aimed to evaluate surface dye penetration of two conventional glass ionomer cements (GIC), one of them a high viscous ionomer. Methods: 20 standard disk samples measuring 2 mm thick and 4 mm in diameter were made for each conventional GIC. The high viscous ionomer was used as the control (Group 1). Samples were embedded in wax and submitted to pH cycling for 7 days simulating a high cariogenic challenge in a kiln (37ºC). All samples were brushed with an extra-soft bristles infant toothbrush to mimic oral hygiene after exposure to a demineralizing solution for 6 hours. The samples were immersed in a 1% methylene blue solution for 2 hours at the end of cycling. The Mann-Whitney Rank Sum Test was used to analyze the difference between the two GIC. Results: All samples disclosed a superficial dye penetration of 0.6 to 1.5 mm depth. There was no statistical d ifference b etween t he G IC t ested ( p = 0.883). Conclusion: Both GIC tested in this study exhibited superficial dye penetration to depths of at least until their superficial third. Objetivo: Este estudo in vitro objetivou avaliar a infiltração superficial de dois cimentos de ionômero de vidro (CIV) convencionais, sendo um de alta viscosidade. Método: 20 amostras de discos padronizados de CIV, com 2 mm de espessura e 4 mm de diâmetro, foram feitos para cada grupo. O CIV de alta viscosidade foi utilizado como controle (Grupo 1). Esses corpos de prova foram embutidos em blocos de cera e submetidos à ciclagem de pH por 7 dias, a fim de simular um alto desafio cariogênico em estufa à 37º C. Todas as amostras foram escovadas com uma escova de dentes infantil de cerdas extra macias para reproduzir a higiene bucal após a exposição por 6 horas a solução desmineralizante. Ao final do processo de ciclagem de pH os corpos de prova foram submersos em azul de metileno à 1% por 2 horas. O teste estatístico Mann-Whitney foi usado para avaliar a diferença entre os dois CIV. Resultados: Todas as amostras tiveram mais de 0,5 mm de infiltração superficial. Não ocorreu diferença estatística significante entre os CIV testados (p = 0,883). Conclusão: Ambos CIV testados no presente estudo apresentaram infiltração superficial de corante na profundidade de até pelo menos um terço a partir da sua superfície.

Het hanteren van muizen aan de staart wekt bij de dieren een stressrespons op. Deze techniek is echter in de meeste laboratoria nog steeds gebruikelijk. Reden hiervoor ligt grotendeels bij het praktische aspect van het gebruik van deze techniek. Of hanteren met behulp van een buis, dat minder stress veroorzaakt bij de muizen, praktisch toepasbaar is, is de kern van dit onderzoek.

Bacillus spp. have long been used as biocontrol agents because of their efficient broad-spectrum antimicrobial activity. We identified a novel strain of Bacillus atrophaeus, named JZB120050, from soil. B. atrophaeus JZB120050 had a strong inhibitory effect against Botrytis cinerea and many other phytopathogens. Gas chromatography-mass spectrometry showed that B. atrophaeus JZB120050 produced many secondary metabolites, such as alkanes, alkenes and acids; some of which were related to pathogen inhibition. Enzyme activity analysis showed that B. atrophaeus JZB120050 secreted cell-wall-degrading enzymes, including chitinase, glucanase and protease, which degraded fungal cell walls. Both the novel glucanase gene bglu and chitinase gene chit1 were cloned and heterologously expressed in Escherichia coli and the products showed strong enzyme activity. In addition, B. atrophaeus JZB120050 secreted siderophores and formed a significant biofilm. Future studies should focus on these antimicrobial factors to facilitate widespread application in the field of agricultural biocontrol.

Spermatogenesis and sperm ultrastructure were studied by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) in the longidorid Xiphinema theresiae. All germ cell stages, except spermatogonia, are present in the testes of young adult males. The nonflagellated, slightly elongated sperm displays little intraspecific variation and, although never polarized into a head and tail region, has a remarkably precise form, with a high degree of internal organization. Incipient fingerlike pseudopodia appear in the young spermatid and increase to such an extent that the adult sperm has a conspicuous "woolly" appearance. Microfilament bundles encircle the perinuclear mitochondria in the spermatid, and seem to be closely associated with the evaginated plasma membrane, especially in the spermatozoon. A large nucleus with nuclear envelope is prominent in the spermatocyte, but the envelope is absent in the young spermatid. Mitochondria are present in all germ cell stages and undergo certain morphological changes (e.g., in size and number, presence or absence of cristae), as well as changes in intracellular movements during spermatogenesis. Membranous organelles are prominent in the spermatocyte, but disappear in the older spermatid. Annulate lamellae and a residual body (i.e., cytophore) are conspicuous in the spermatocyte and spermatid, respectively; the spermatozoon clearly lacks a refringent body (i.e., acrosome).

A study was undertaken to determine the feasibility of introducing a computerised electrocardiographic analysis and interpretive system as a service to a teaching and referral hospital. Available computer equipment and programmes are considered. The accuracy and quality of the analysis and interpretation of the electrocardiographic contours are basically dependent on such factors as pattern recognition, the criteria adopted for determining abnormalities, the relative values placed on scalar and orthogonal leads and the role of review by the physician. It is concluded that such systems are at a stage where they can feasibly be introduced and should be of advantage in freeing the physician from ,routine measuring and screening of electrocardiograms, thus saving many hours of professional and academic time. Furthermore, such systems can contribute greatly as an educational tool and increase the general knowledge of electrocardiography. Systems for storage and retrieval are also being developed and becoming available. The whole field is a developing one and continuous updating of programmes by the addition of more data, particularly for children, and the introduction of electrocardiographic comparison programmes need to be expedited.S. Afr. Med. J., 48, 1141 (1974).

Xiphinema stockeri n. sp. is described from Botswana The new species is characterized by an exceptionally long and conspicuous peg on the tail, and seems to be most closely related to X. mammatum Siddiqi, 1979, from which it can be distinguished by the a ratio, odontostyle and total stylet length, spicule length, the shape of the lip region and tail peg and the presence of a pseudo-z differentiation in X. stockeri.

The Archaeological Journal, 90, 18-25

The Archaeological Journal, 93, 1-12

Verpleegkundigen kunnen het beloop van specifieke gezondheidsproblemen van kwetsbare ouderen gunstig beïnvloeden. Dat kan alleen als ze deze problemen tijdig inschatten en verbanden kunnen leggen tussen de verschillende problemen en de wisselwerking die deze op elkaar hebben. Het klinisch redeneren bij kwetsbare ouderen wordt in het beroepsprofiel verpleegkundige expliciet genoemd als belangrijke vaardigheid om dit doel te bereiken. 'Klinisch redeneren bij ouderen' biedt de kennis die verpleegkundigen nodig hebben om, samen met de oudere, kritische besluiten te nemen in alle stappen van het verpleegkundige proces.

Nkomazi local municipality of South Africa is a high-risk malaria region with an incidence rate of about 500 cases per 100 000. We examined the influence of environmental factors on population (age group) at risk of malaria.r software was used to statistically analyse data. Using remote sensing technology, a Landsat 8 image of 4th October 2015 was classified using object-based classification and a 5-m resolution. Spot height data were used to generate a digital elevation model of the area.A total of 60 718 malaria cases were notified across 48 health facilities in Nkomazi municipality between January 1997 and August 2015. Malaria incidence was highly associated with irrigated land (P = 0.001), water body (P = 0.011) and altitude ≤400 m (P = 0.001). The multivariate model showed that with 10% increase in the extent of irrigated areas, malaria risk increased by almost 39% in the entire study area and by almost 44% in the 2-km buffer zone of selected villages. Malaria incidence is more pronounced in the economically active population aged 15-64 and in males. Both incidence and case fatality rate drastically declined over the study period.A predictive model based on environmental factors would be useful in the effort towards malaria elimination by fostering appropriate targeting of control measures and allocating of resources.

Introduction: INSTRUCT (CellCoTec B.V., Netherlands) is a technology that combines freshly isolated autologous chondrocytes and mono-nucleated cells from bone marrow with a porous scaffold filling the defect and providing cartilage matching mechanical stability. Based on (pre-)clinical data it is anticipated[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

PubMed: 26787795, Background: Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe. Methods: We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013. Results: The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl-1 and increased to 9.8 (1.8) g dl-1 after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2). Conclusions: Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl-1), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold. © 2016 The Author. Published by Oxford University Press on behalf of the British Journal of Anaesthesia.

Thesis (doctoral)--PU for CHE "No abstract available" Doctoral

[Objective] HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The objective was to identify factors associated with loss of virological control., [Methods] HICs were identified in COHERE on the basis of ≥5 consecutive viral loads (VL) ≤500 copies/mL over ≥1 year whilst ART-naive, with the last VL ≤500 copies/mL measured ≥5 years after HIV diagnosis. Loss of virological control was defined as 2 consecutive VL >2000 copies/mL. Duration of HIV control was described using cumulative incidence method, considering loss of virological control, ART initiation and death during virological control as competing outcomes. Factors associated with loss of virological control were identified using Cox models. CD4 and CD8 dynamics were described using mixed-effect linear models., [Results] We identified 1067 HICs; 86 lost virological control, 293 initiated ART, and 13 died during virological control. Six years after confirmation of HIC status, the probability of losing virological control, initiating ART and dying were 13%, 37%, and 2%. Current lower CD4/CD8 ratio and a history of transient viral rebounds were associated with an increased risk of losing virological control. CD4 declined and CD8 increased before loss of virological control, and before viral rebounds., [Discussion] Expansion of CD8 and decline of CD4 during HIV control may result from repeated low-level viremia. Our findings suggest that in addition to superinfection, other mechanisms, such as low grade viral replication, can lead to loss of virological control in HICs., The COHERE study group has received unrestricted funding from: Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (ANRS), France; HIV Monitoring Foundation, The Netherlands; and the Augustinus Foundation, Denmark. The research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant agreement n° 260694.

Our main concern in proposing these applications is to provide a tool, with is the Data Envelopment Analysis (DEA) approach, for contributing to monitoring and evaluating programs, projects or development activities of the national health system.DEA approach was applied using the Charnes, Cooper and Rhodes (CCR) model, to calculate the indices measuring the performance efficiencies and Malmquist indices for measuring changes in productivity of health regions and districts.The results obtained show that the health system of Burkina Faso through the regions or districts had a low progress but that the system on variables used may well occur with the inputs allocated. This can also be seen through the huge disparities in performance efficiency scores of different regions and districts of the health system.While conventional methods are already used for the case of Burkina Faso to analyze the performances, it will be a first time that DEA approach was used to analyze the performance of the health system.; L'objectif principal en proposant ces applications est de proposer l'approche " Data EnvelopmentAnalysis (DEA)" comme coutil de suivi et d'évaluation des programmes, projets ou le développement des activités du système national de santé. L'approche DEA est appliquée en utilisant le modèle de Charnes, Cooper and Rhodes(CCR), pour calculer les indices de mesure de performance et les indices de productivité de Malmquist pour mesurer les variations de productivité dans les régions et districts sanitaires. Les résultats obtenus montrent que le système de santé au Burkina Faso à travers les régions ou districts a connu un faible progrès mais le système relativement aux critères utilisés aurait pu accroître en termes de résultats vu les ressources allouées. Ces résultats permettent de constater une grande disparité en termes de performance des régions et districts du système national de santé. Des méthodes conventionnelles classiques sont déjà utilisées pour le cas du Burkina Faso pour analyser les performances, il nous semble être la première fois que l'approche DEA est utilisée pour analyser les performances du système burkinabé de santé.

Our main concern in proposing these applications is to provide a tool, with is the Data Envelopment Analysis (DEA) approach, for contributing to monitoring and evaluating programs, projects or development activities of the national health system.DEA approach was applied using the Charnes, Cooper and Rhodes (CCR) model, to calculate the indices measuring the performance efficiencies and Malmquist indices for measuring changes in productivity of health regions and districts.The results obtained show that the health system of Burkina Faso through the regions or districts had a low progress but that the system on variables used may well occur with the inputs allocated. This can also be seen through the huge disparities in performance efficiency scores of different regions and districts of the health system.While conventional methods are already used for the case of Burkina Faso to analyze the performances, it will be a first time that DEA approach was used to analyze the performance of the health system., L'objectif principal en proposant ces applications est de proposer l'approche " Data EnvelopmentAnalysis (DEA)" comme coutil de suivi et d'évaluation des programmes, projets ou le développement des activités du système national de santé. L'approche DEA est appliquée en utilisant le modèle de Charnes, Cooper and Rhodes(CCR), pour calculer les indices de mesure de performance et les indices de productivité de Malmquist pour mesurer les variations de productivité dans les régions et districts sanitaires. Les résultats obtenus montrent que le système de santé au Burkina Faso à travers les régions ou districts a connu un faible progrès mais le système relativement aux critères utilisés aurait pu accroître en termes de résultats vu les ressources allouées. Ces résultats permettent de constater une grande disparité en termes de performance des régions et districts du système national de santé. Des méthodes conventionnelles classiques sont déjà utilisées pour le cas du Burkina Faso pour analyser les performances, il nous semble être la première fois que l'approche DEA est utilisée pour analyser les performances du système burkinabé de santé.