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Your search keyword '"Daitetsu Kato"' showing total 2 results
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2 results on '"Daitetsu Kato"'

1. Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy

Author

Yo Shinoda, Daitetsu Kato, Ryosuke Ando, Hikaru Endo, Tsutomu Takahashi, Yayoi Tsuneoka, and Yasuyuki Fujiwara

Subjects
5-aminolevulinic acid, 5-ALA, dALA, δALA, PpIX, protoporphyrin IX, Medicine, Pharmacy and materia medica, RS1-441
Abstract

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These clinical applications are potentially based on in vitro cell culture experiments. Thus, conducting a systematic review and meta-analysis of in vitro 5-ALA PDT experiments is meaningful and may provide opportunities to consider future perspectives in this field. We conducted a systematic literature search in PubMed to summarize the in vitro 5-ALA PDT experiments and calculated the effectiveness of 5-ALA PDT for several cancer cell types. In total, 412 articles were identified, and 77 were extracted based on our inclusion criteria. The calculated effectiveness of 5-ALA PDT was statistically analyzed, which revealed a tendency of cancer-classification-dependent sensitivity to 5-ALA PDT, and stomach cancer was significantly more sensitive to 5-ALA PDT compared with cancers of different origins. Based on our analysis, we suggest a standardized in vitro experimental protocol for 5-ALA PDT.

Published
2021
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2. Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy

Author

Hikaru Endo, Ryosuke Ando, Yayoi Tsuneoka, Yo Shinoda, Daitetsu Kato, Tsutomu Takahashi, and Yasuyuki Fujiwara

Subjects
medicine.medical_treatment, 030303 biophysics, Pharmaceutical Science, lcsh:Medicine, lcsh:RS1-441, Photodynamic therapy, Review, δALA, lcsh:Pharmacy and materia medica, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, PDT, Drug Discovery, medicine, polycyclic compounds, protoporphyrin IX, 5-ALA, dALA, Stomach cancer, PpIX, 0303 health sciences, Protoporphyrin IX, business.industry, lcsh:R, medicine.disease, In vitro, eye diseases, Amino acid derivative, chemistry, photodynamic therapy, 5-aminolevulinic acid, 030220 oncology & carcinogenesis, Meta-analysis, Cancer cell, Cancer research, Molecular Medicine, business, Human cancer
Abstract

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These clinical applications are potentially based on in vitro cell culture experiments. Thus, conducting a systematic review and meta-analysis of in vitro 5-ALA PDT experiments is meaningful and may provide opportunities to consider future perspectives in this field. We conducted a systematic literature search in PubMed to summarize the in vitro 5-ALA PDT experiments and calculated the effectiveness of 5-ALA PDT for several cancer cell types. In total, 412 articles were identified, and 77 were extracted based on our inclusion criteria. The calculated effectiveness of 5-ALA PDT was statistically analyzed, which revealed a tendency of cancer-classification-dependent sensitivity to 5-ALA PDT, and stomach cancer was significantly more sensitive to 5-ALA PDT compared with cancers of different origins. Based on our analysis, we suggest a standardized in vitro experimental protocol for 5-ALA PDT.

Published
2021

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