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1. Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease

Author

Kara, Firat, Belloy, Michael E., Voncken, Rick, Sarwari, Zahra, Garima, Yadav, Anckaerts, Cynthia, Langbeen, An, Leysen, Valerie, Shah, Disha, Jacobs, Jules, Hamaide, Julie, Bols, Peter, Van Audekerke, Johan, Daans, Jasmijn, Guglielmetti, Caroline, Kantarci, Kejal, Prevot, Vincent, Roßner, Steffen, Ponsaerts, Peter, Van der Linden, Annemie, and Verhoye, Marleen

Published
2021
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2. Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

Author

Quarta, Alessandra, Le Blon, Debbie, D'aes, Tine, Pieters, Zoë, Hamzei Taj, Somayyeh, Miró-Mur, Francesc, Luyckx, Evi, Van Breedam, Elise, Daans, Jasmijn, Goossens, Herman, Dewilde, Sylvia, Hens, Niel, Pasque, Vincent, Planas, Anna M., Hoehn, Mathias, Berneman, Zwi, and Ponsaerts, Peter

Published
2019
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4. Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María José, De Laere, Maxime, Lee, Wai-Ping, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, De Reu, Hans, Jolanta Keliris, Aneta, Van Audekerke, Johan, Vanreusel, Verdi, Pieters, Zoë, Van der Linden, Annemie, Verhoye, Marleen, Molenberghs, Geert, Hens, Niel, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Berneman, Zwi N., Martínez-Cáceres, Eva María, and Cools, Nathalie

Published
2019
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7. Long‐term deprivation of ovarian hormones via ovariectomy alters functional connectivity, brain neurochemistry and white matter integrity in a mouse model of Alzheimer's disease

Author

Kara, Firat, primary, Belloy, Michael E, additional, Voncken, Rick, additional, Sarwari, Zahra, additional, Yadav, Garima, additional, Anckaerts, Cynthia, additional, Langbeen, An, additional, Leysen, Valérie, additional, Shah, Disha, additional, Jacobs, Jules, additional, Hamaide, Julie, additional, Bols, Peter, additional, Van Audekerke, Johan, additional, Daans, Jasmijn, additional, Guglielmetti, Caroline, additional, Kantarci, Kejal, additional, Prevot, Vincent, additional, Rossner, Steffen, additional, Ponsaerts, Peter, additional, Van Der Linden, Annemie, additional, and Verhoye, Marleen, additional

Published
2020
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8. Additional file 2: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S2. Graphical overview of the protein structure of murine MOG. (PDF 357 kb)

Published
2019
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9. Additional file 6: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, fungi, hemic and immune systems, chemical and pharmacologic phenomena
Abstract

Figure S6. Flow cytometric evaluation of the proportion of Treg, Breg and NK cells in splenocytes. (PDF 289 kb)

Published
2019
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10. MOESM2 of Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Author

Ben-Nejma, Inès, Keliris, Aneta, Daans, Jasmijn, Ponsaerts, Peter, Verhoye, Marleen, Linden, Annemie Van Der, and Keliris, Georgios

Abstract

Additional file 2: Figure S2.Time evolution of FC in regions of the DMN network. Each graph shows the FC over time of a specific region. Results are shown as mean ± SEM. Significant [Genotype*Time] interaction and Time effect are indicated with stars and dotted line, respectively. *p

Published
2019
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11. Additional file 1: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, fungi, education, psychological phenomena and processes
Abstract

Figure S1. Graphical overview of the culture protocol for murine bone marrow-derived dendritic cells. (PDF 271 kb)

Published
2019
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12. Additional file 5: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S5. Representation of individual clinical scores. (PDF 349 kb)

Published
2019
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13. Additional file 3: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S3. Nucleotide sequence of the Sig-full length MOG-LAMP-3 and Sig-extracellular MOG-LAMP-3 constructs. (PDF 385 kb)

Published
2019
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14. Additional file 7: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
nervous system, fungi
Abstract

Table S1. Amino acid sequences of the myelin peptides used for screening for inter- and intramolecular epitope spreading. (PDF 317 kb)

Published
2019
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15. Additional file 4: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Figure S4. Graphical overview of the experimental set-up of the in vivo experiment. (PDF 279 kb)

Published
2019
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16. Additional file 8: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, immune system diseases, fungi, nervous system diseases
Abstract

Table S2. Clinical data of MOG35–55 EAE mice. (PDF 393 kb)

Published
2019
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19. Immune remodelling of stromal cell grafts in the central nervous system : therapeutic inflammation or (harmless) side-effect?

Author

Le Blon, Debbie, Hoornaert, Chloé, Detrez, Jan, Bevers, Sanne, Daans, Jasmijn, Goossens, Herman, De Vos, Winnok, Berneman, Zwi Nisan, and Ponsaerts, Peter

Subjects
Human medicine, Biology, Engineering sciences. Technology
Abstract

Over the past two decades, several cell types with fibroblast-like morphology, including mesenchymal stem/stromal cells, but also other adult, embryonic and extra-embryonic fibroblast-like cells, have been brought forward in the search for cellular therapies to treat severe brain injuries and/or diseases. Although current views in regenerative medicine are highly focused on the immune modulating and regenerative properties of stromal cell transplantation in vivo, many open questions remain regarding their true mode of action. In this perspective, this study integrates insights gathered over the past 10 years to formulate a unifying model of the cellular events that accompany fibroblast-like cell grafting in the rodent brain. Cellular interactions are discussed step-by-step, starting from the day of implantation up to 10 days after transplantation. During the short period that precedes stable settlement of autologous/syngeneic stromal cell grafts, there is a complex interplay between hypoxia-mediated cell death of grafted cells, neutrophil invasion, microglia and macrophage recruitment, astrocyte activation and neo-angiogenesis within the stromal cell graft site. Consequently, it is speculated that regenerative processes following cell therapeutic intervention in the CNS are not only modulated by soluble factors secreted by grafted stromal cells (bystander hypothesis), but also by in vivo inflammatory processes following stromal cell grafting. Copyright © 2016 John Wiley & Sons, Ltd.

Published
2017

20. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Author

Guglielmetti, Caroline, Le Blon, Debbie, Santermans, Eva, Salas-Perdomo, Angelica, Daans, Jasmijn, De Vocht, Nathalie, Shah, Disha, Hoornaert, Chloé, Praet, Jelle, Peerlings, Jurgen, Kara, Firat, Bigot, Christian, Mai, Zhenhua, Hens, Niels, Hendrix, Sven, Verhoye, Marleen, Planas, Anna M, Berneman, Zwi, Van der Linden, Annemie, and Ponsaerts, Peter

Subjects
magnetic resonance imaging, demyelination, multiple sclerosis
Abstract

Detrimental inflammatory responses in the central nervous system are a hallmark of various brain injuries and diseases. With this study we provide evidence that lentiviral vector-mediated expression of the immune-modulating cytokine interleukin 13 (IL-13) induces an alternative activation program in both microglia and macrophages conferring protection against severe oligodendrocyte loss and demyelination in the cuprizone mouse model for multiple sclerosis (MS). First, IL-13 mediated modulation of cuprizone induced lesions was monitored using T2-weighted magnetic resonance imaging and magnetization transfer imaging, and further correlated with quantitative histological analyses for inflammatory cell influx, oligodendrocyte death, and demyelination. Second, following IL-13 immune gene therapy in cuprizone-treated eGFP+ bone marrow chimeric mice, we provide evidence that IL-13 directs the polarization of both brain-resident microglia and infiltrating macrophages towards an alternatively activated phenotype, thereby promoting the conversion of a pro-inflammatory environment toward an anti-inflammatory environment, as further evidenced by gene expression analyses. Finally, we show that IL-13 immune gene therapy is also able to limit lesion severity in a pre-existing inflammatory environment. In conclusion, these results highlight the potential of IL-13 to modulate microglia/macrophage responses and to improve disease outcome in a mouse model for MS.

Published
2016
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22. In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

Author

Hoornaert, Chloé C.J., Verbeeck, Louca, Quarta, Alessandra, De Vocht, Nathalie, Lemmens, Evi, Goossens, Herman, van der linden, Annemie, Roobrouck, Valerie V.D., Verfaillie, Catherine, Hendrix, Sven, Moser, Muriel, Luyckx, Evi, Berneman, Zwi Nisan, Ponsaerts, Peter, Reekmans, Kristien, Dhainaut, Maxime, Guglielmetti, Caroline, Le Blon, Debbie, Dooley, Dearbhaile, Fransen, Erik, Daans, Jasmijn, Hoornaert, Chloé C.J., Verbeeck, Louca, Quarta, Alessandra, De Vocht, Nathalie, Lemmens, Evi, Goossens, Herman, van der linden, Annemie, Roobrouck, Valerie V.D., Verfaillie, Catherine, Hendrix, Sven, Moser, Muriel, Luyckx, Evi, Berneman, Zwi Nisan, Ponsaerts, Peter, Reekmans, Kristien, Dhainaut, Maxime, Guglielmetti, Caroline, Le Blon, Debbie, Dooley, Dearbhaile, Fransen, Erik, and Daans, Jasmijn

Abstract

Transplantation of mesenchymal stem cells (MSCs) into injured or diseased tissue—for the in situ delivery of a wide variety of MSC-secreted therapeutic proteins—is an emerging approach for the modulation of the clinical course of several diseases and traumata. From an emergency point-of-view, allogeneic MSCs have numerous advantages over patient-specific autologous MSCs since “off-the-shelf” cell preparations could be readily available for instant therapeutic intervention following acute injury. Although we confirmed the in vitro immunomodulatory capacity of allogeneic MSCs on antigen-presenting cells with standard coculture experiments, allogeneic MSC grafts were irrevocably rejected by the host's immune system upon either intramuscular or intracerebral transplantation. In an attempt to modulate MSC allograft rejection in vivo, we transduced MSCs with an interleukin-13 (IL13)-expressing lentiviral vector. Our data clearly indicate that prolonged survival of IL13-expressing allogeneic MSC grafts in muscle tissue coincided with the induction of an alternatively activated macrophage phenotype in vivo and a reduced number of alloantigen-reactive IFNγ- and/or IL2-producing CD8+ T cells compared to nonmodified allografts. Similarly, intracerebral IL13-expressing MSC allografts also exhibited prolonged survival and induction of an alternatively activated macrophage phenotype, although a peripheral T cell component was absent. In summary, this study demonstrates that both innate and adaptive immune responses are effectively modulated in vivo by locally secreted IL13, ultimately resulting in prolonged MSC allograft survival in both muscle and brain tissue. Stem Cells 2016;34:1971–1984., SCOPUS: ar.j, FLWOA, info:eu-repo/semantics/published

Published
2016

23. Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Author

Le Blon, Debbie, primary, Guglielmetti, Caroline, additional, Hoornaert, Chloé, additional, Quarta, Alessandra, additional, Daans, Jasmijn, additional, Dooley, Dearbhaile, additional, Lemmens, Evi, additional, Praet, Jelle, additional, De Vocht, Nathalie, additional, Reekmans, Kristien, additional, Santermans, Eva, additional, Hens, Niel, additional, Goossens, Herman, additional, Verhoye, Marleen, additional, Van der Linden, Annemie, additional, Berneman, Zwi, additional, Hendrix, Sven, additional, and Ponsaerts, Peter, additional

Published
2016
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24. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Author

Guglielmetti, Caroline, primary, Le Blon, Debbie, additional, Santermans, Eva, additional, Salas-Perdomo, Angelica, additional, Daans, Jasmijn, additional, De Vocht, Nathalie, additional, Shah, Disha, additional, Hoornaert, Chloé, additional, Praet, Jelle, additional, Peerlings, Jurgen, additional, Kara, Firat, additional, Bigot, Christian, additional, Mai, Zhenhua, additional, Goossens, Herman, additional, Hens, Niel, additional, Hendrix, Sven, additional, Verhoye, Marleen, additional, Planas, Anna M., additional, Berneman, Zwi, additional, van der Linden, Annemie, additional, and Ponsaerts, Peter, additional

Published
2016
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26. In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

Author

Hoornaert, Chloé J., primary, Luyckx, Evi, additional, Reekmans, Kristien, additional, Dhainaut, Maxime, additional, Guglielmetti, Caroline, additional, Le Blon, Debbie, additional, Dooley, Dearbhaile, additional, Fransen, Erik, additional, Daans, Jasmijn, additional, Verbeeck, Louca, additional, Quarta, Alessandra, additional, De Vocht, Nathalie, additional, Lemmens, Evi, additional, Goossens, Herman, additional, Van der Linden, Annemie, additional, Roobrouck, Valerie D., additional, Verfaillie, Catherine, additional, Hendrix, Sven, additional, Moser, Muriel, additional, Berneman, Zwi N., additional, and Ponsaerts, Peter, additional

Published
2016
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28. Early Inflammatory Responses following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events

Author

Praet, Jelle, primary, Santermans, Eva, additional, Daans, Jasmijn, additional, Le Blon, Debbie, additional, Hoornaert, Chloé, additional, Goossens, Herman, additional, Hens, Niel, additional, Van Der Linden, Annemie, additional, Berneman, Zwi, additional, and Ponsaerts, Peter, additional

Published
2015
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29. Cuprizone‐induced demyelination and demyelination‐associated inflammation result in different proton magnetic resonance metabolite spectra

Author

Praet, Jelle, primary, Orije, Jasmien, additional, Kara, Firat, additional, Guglielmetti, Caroline, additional, Santermans, Eva, additional, Daans, Jasmijn, additional, Hens, Niel, additional, Verhoye, Marleen, additional, Berneman, Zwi, additional, Ponsaerts, Peter, additional, and Van der Linden, Annemie, additional

Published
2015
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30. Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

Author

Costa, Roberta, primary, Bergwerf, Irene, additional, Santermans, Eva, additional, De Vocht, Nathalie, additional, Praet, Jelle, additional, Daans, Jasmijn, additional, Le Blon, Debbie, additional, Hoornaert, Chloé, additional, Reekmans, Kristien, additional, Hens, Niel, additional, Goossens, Herman, additional, Berneman, Zwi, additional, Parolini, Ornella, additional, Alviano, Francesco, additional, and Ponsaerts, Peter, additional

Published
2015
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