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The predictive value of the respiratory rate‑oxygenation (ROX) index for a high-flow nasal cannula (HFNC) in patients with COVID-19 with acute hypoxemic respiratory failure (AHRF) may differ from patients without COVID-19 with AHRF, but these patients have not yet been compared. We compared the diagnostic accuracy of the ROX index for HFNC failure in patients with AHRF with and without COVID-19 during acute emergency department (ED) visits. We performed a retrospective analysis of patients with AHRF treated with an HFNC in an ED between October 2020 and April 2022. The ROX index was calculated at 1, 2, 4, 6, 12, and 24 h after HFNC placement. The primary outcome was the failure of the HFNC, which was defined as the need for subsequent intubation or death within 72 h. A receiver operating characteristic (ROC) curve was used to evaluate discriminative power of the ROX index for HFNC failure. Among 448 patients with AHRF treated with an HFNC in an ED, 78 (17.4%) patients were confirmed to have COVID-19. There was no significant difference in the HFNC failure rates between the non-COVID-19 and COVID-19 groups (29.5% vs. 33.3%, p = 0.498). The median ROX index was higher in the non-COVID-19 group than in the COVID-19 group at all time points. The prognostic power of the ROX index for HFNC failure as evaluated by the area under the ROC curve was generally higher in the COVID-19 group (0.73–0.83) than the non-COVID-19 group (0.62–0.75). The timing of the highest prognostic value of the ROX index for HFNC failure was at 4 h for the non-COVID-19 group, whereas in the COVID-19 group, its performance remained consistent from 1 h to 6 h. The optimal cutoff values were 6.48 and 5.79 for the non-COVID-19 and COVID-19 groups, respectively. The ROX index had an acceptable discriminative power for predicting HFNC failure in patients with AHRF with and without COVID-19 in the ED. However, the higher ROX index thresholds than those in previous publications involving intensive care unit (ICU) patients suggest the need for careful monitoring and establishment of a new threshold for patients admitted outside the ICU. [ABSTRACT FROM AUTHOR]

• An integrated sampling scheme with adjustable mechanisms is developed. • The OC and ASN functions were derived based on the exact sampling distribution. • Establishment of a nonlinear optimization model to determine optimal plan design. • Several analyses on performance metrics are investigated, compared and discussed. • Development of a web-based application to assist practitioners to obtain optimal plan design. Acceptance sampling plans are statistical quality control methods commonly used to efficiently verify product quality under controlled risks. Recent research has developed the multiple dependent-state sampling plan (MDSP), which incorporates historical lot quality information, and the repetitive group sampling plan (RGSP), which allows for repeat sampling, to enhance the cost-effectiveness of sampling inspections. The modified RGSP (MRGSP) integrates the sampling mechanisms of both MDSP and RGSP. However, investigative analyses have uncovered significant deficiencies in the sampling mechanisms of MDSP and RGSP, with potential problems in MRGSP being even more severe. Therefore, this paper proposes an adjustable MRGSP (AMRGSP) based on unilateral process capability indices to establish a more adaptive and flexible sampling mechanism, reducing the limitations of MRGSP. We derive the operational characteristic function and average sample number function of AMRGSP, and establish a nonlinear optimization model considering Type I and II errors to determine the optimal plan design. Performance comparisons of the proposed AMRGSP with recent sampling plans revealed that the proposed plan offers reliable lot discriminative power and significantly reduces the sample size required for inspection, providing excellent cost-effectiveness. Finally, we evaluate the proposed plan using a practical case study to demonstrate its applicability in practice. [ABSTRACT FROM AUTHOR]

Conversational search systems, such as Google assistant and Microsoft Cortana, enable users to interact with search systems in multiple rounds through natural language dialogues. Evaluating such systems is very challenging, given that any natural language responses could be generated, and users commonly interact for multiple semantically coherent rounds to accomplish a search task. Although prior studies proposed many evaluation metrics, the extent of how those measures effectively capture user preference remain to be investigated. In this article, we systematically meta-evaluate a variety of conversational search metrics. We specifically study three perspectives on thosemetrics: (1) reliability: the ability to detect "actual" performance differences as opposed to those observed by chance; (2) fidelity: the ability to agree with ultimate user preference; and (3) intuitiveness: the ability to capture any property deemed important: adequacy, informativeness, and fluency in the context of conversational search. By conducting experiments on two test collections, we find that the performance of different metrics vary significantly across different scenarios, whereas consistent with prior studies, existing metrics only achieve weak correlation with ultimate user preference and satisfaction. METEOR is, comparatively speaking, the best existing single-turn metric considering all three perspectives. We also demonstrate that adapted session-based evaluation metrics can be used to measure multi-turn conversational search, achieving moderate concordance with user satisfaction. To our knowledge, our work establishes the most comprehensive meta-evaluation for conversational search to date. [ABSTRACT FROM AUTHOR]

Estimation of the level of durum wheat germplasm genetic diversity is important for its classification and efficient use in breeding programmes. The aim of this study was to assess genetic diversity of durum wheat genotypes developed at the Institute of Field and Vegetable Crops in Novi Sad, Serbia, with 26 morphological characteristics based on the International Union for Protection of New Varieties of Plants guidelines. The Shannon diversity index was used as an indicator of morphological diversity and it ranged from 0.283 for glaucosity of lower side of the flag leaf blade and density of hairiness of uppermost node of the culm, to 0.950 for the ear colour, with the mean value of 0.616, indicating a medium to high level of morphological diversity. On average, the diversity was higher for traits relating to generative organs than for those associated with vegetative plant organs. The 21 morphological characteristics were sufficient to distinguish unique profiles of all durum wheat genotypes. The estimation of varietal diversity and identification of morphological characteristics with the highest discriminative power were done by multiple correspondence analysis. The traits that contributed the most to the distinction of genotypes were the ear colouration, length of beak of the lower glume, lower glume shape, ear length of awns at tip relative to ear length and colour of awns. Morphological characterization using the traits with the highest discriminative power could be a useful complementary method for durum wheat germplasm classification and diversity analysis.

Abstract Background Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer’s disease (AD) pathology. A clinical cerebrospinal fluid biomarker capable of monitoring this process during the course of the disease has yet to emerge, chiefly owing to contradictory research findings. In this study, we sought to clarify the utility of inflammatory biomarkers in diagnostic procedures of AD in three steps: (1) to screen for proteins that are robustly detectable in cerebrospinal fluid; (2) based on this analysis, to explore any associations between the analytically robust markers and salient pathological features of AD; and (3) to determine the discriminative power of these markers in the clinical diagnosis of AD. Methods From a total of 46 proteins, 15 that were robustly detectable in cerebrospinal fluid were identified. A subsequent analysis of these markers in a cohort of 399 patients (nondemented subjects, patients with mild cognitive impairment [MCI], and patients with AD, supplemented by smaller cohorts of other diseases) was conducted. Fluid biomarker data were related to AD pathology and neuropsychological markers and adjusted for confounders such as age, sex, apolipoprotein E genotype, and biobank storage time. Results Cerebrospinal fluid levels of C-reactive protein and soluble TREM2 differed between nondemented subjects, patients with MCI, or patients with AD and were associated with amyloid and tau pathology. Several markers were associated with tau pathology only or with other neurodegenerative diseases. Correlations between neuropsychological performance and inflammatory markers were weak, but they were most prominent in AD and for the most challenging cognitive tests. All investigated covariates had significant influence, with varying effects across the markers. Still, none of the markers achieved discriminative power of more than 70% to distinguish between patient groups defined by clinical or neuropathological categories. Conclusions Basic analytical considerations proved indispensable for this type of study because only one-third of the tested markers were robustly detectable in cerebrospinal fluid. Detectable inflammatory protein markers were associated in multiple ways with AD pathology. Yet, even significantly associated markers were not powerful enough in terms of effect strength, sensitivity, and specificity, and hence they were not suited for direct use in clinical diagnostic practice. Targets other than those most commonly considered in this field of research might provide results with better clinical applicability.

Objectives: In China, multiple approaches to calculating EQ-5D utilities are available, including the two EQ-5D-3L (3L2014 and 3L2018) scoring functions, the EQ-5D-5L (5L) scoring function, and the crosswalk function linking the 3L utilities and 5L health states. The study compared utilities derived from them in terms of agreement and discriminative power; and assessed whether the use of different approaches may affect QALY estimation in Chinese type 2 diabetes (T2D) patients. Methods: Cross-sectional data of 289 T2D patients who self-completed both the 5L and 3L questions were used. Agreement were examined using intraclass correlation coefficient (ICC) and Bland–Altman plots. The ability of the EQ-5D utilities in differentiating the patients with and without clinical conditions was evaluated using F-statistics. Their influence on QALY estimation was assessed adopting mean absolute difference (MAD) in utility values between the patients. Results: The ICC values were 0.881 (3L2014-3L2018), 0.958 (5L-c5L2014), and 0.806 (5L-c5L2018). The two 3L utilities and the three 5L utilities had poor agreement at the lower end of utility scale according to Bland–Altman plots. The 3L2018 utilities had lower F-statistics compared to the 3L2014 utilities; the two c5L utilities had larger or similar F-statistics compared to the 5L utilities. The mean MADs were 0.138 (5L), 0.116 (3L2014), 0.115 (c5L2014), 0.055 (c5L2018), and 0.055 (3L2018). Conclusion: The 3L2014 utilities is more discriminative than the 3L2018 utilities; and the two c5L utilities have no worse discriminative power compared with the 5L utilities. The choice of the approach to calculating the EQ-5D utilities is likely to affect QALY estimates. [ABSTRACT FROM AUTHOR]

The evaluation of recommender systems is an area with unsolved questions at several levels. Choosing the appropriate evaluation metric is one of such important issues. Ranking accuracy is generally identified as a prerequisite for recommendation to be useful. Ranking metrics have been adapted for this purpose from the Information Retrieval field into the recommendation task. In this article, we undertake a principled analysis of the robustness and the discriminative power of different ranking metrics for the offline evaluation of recommender systems, drawing from previous studies in the information retrieval field. We measure the robustness to different sources of incompleteness that arise from the sparsity and popularity biases in recommendation. Among other results, we find that precision provides high robustness while normalized discounted cumulative gain offers the best discriminative power. In dealing with cold users, we also find that the geometric mean is more robust than the arithmetic mean as aggregation function over users. [ABSTRACT FROM AUTHOR]

Research in Keystroke-Dynamics (KD) has customarily focused on temporal features without considering context to generate user templates that are used in authentication. Additionally, work on KD in hand-held devices such as smart-phones and tablets have shown that these features alone do not perform satisfactorily for authentication. In this work, we analyze the discriminatory power of the most-used conventional features found in the literature, propose a set of context-sensitive or word-specific features, and analyze the discriminatory power of proposed features using their classification results. To perform these tasks, we use the keystroke data consisting of over 650K keystrokes, collected from 20 unique users during different activities on desktops, tablets, and phones, over a span of two months. On an average, each user made 12.5K, 9K, and 10K keystrokes on desktop, tablet, and phone, respectively. We find that the conventional features are not highly discriminatory on desktops and are only marginally better on hand-held devices for user identification. By using information of the context, a subset (derived after analysis) of our proposed word-specific features offers superior discrimination among users on all devices. We find that a majority of the classifiers, built using these features, perform user identification well with accuracies in the range of 90% to 97%, average precision and recall values of 0.914 and 0.901, respectively, on balanced test samples in 10-fold cross validation. We also find that proposed features work best on handheld devices. This work calls for a shift from using conventional KD features to a set of context-sensitive or word-specific KD features that take advantage of known information such as context. [ABSTRACT FROM AUTHOR]

This paper presents a novel technique called correspondence selection for rigid transformations in order to effectively refine keypoint matches in rigid image registration. The proposed technique mainly lies in the following two components. First, keypoint matches are ranked and selected by the distance ratio between the best match and the second best match. Second, keypoint matches are further selected by ranking the geometric similarity between corresponding keypoint triplets. These two components enhance the discriminative power of potential keypoint matches in a progressive way. The proposed technique is generally applicable to affine rigid image registration. Experiments have been conducted using a set of benchmark datasets in the field of image registration, indicating that the proposed technique is very effective and achieves the state-of-the-art performance in refining keypoint matches for affine rigid image registration.

The concept of biodiesel viewed by pundits as a renewable alternative fuel to diesel engines that could partially or fully replace or reduce the use of petroleum diesel fuel has been gaining great importance worldwide for its good quality exhaust, sustainability and biodegradability. The irregularity in production output, low quality, wastes, and downtimes appears to be a serious production problem being faced by manufacturers of biodiesel products which this study seeks to address. This study seeks to analyze some factors affecting the production process of rubber seed oil based biodiesel using opinion discrimination analysis. The research entails the application of survey method to gather relevant information required to build appropriate data matrix of 31 factors that were used to craft questionnaire administered to 100 respondents for their expert evaluation. Rensis Likert’s 5-point attitudinal scale was used in dimensioning the respondent’s responses, which were recorded in descending order of rating and were captured in a 100 × 31 data matrix and subsequently analyzed with the use of opinion discriminative analytical tool to obtain the discriminative powers (DP). The result of the DP-values obtained enabled us to appreciate the main factors that significantly influence the rubber seed oil based biodiesel production. In particular their relative influence is indicative of the magnitude of the DP-values. This study has revealed that the opinion discrimination analytical approach employed is effective in dealing with the problem of process variability and degraded output. Keywords: Discriminative Power, Rubber Seed Oil, Opinion Discrimination Analysis, Rensis Likert

Objective: The main objective of this study is to evaluate the performance of the predictive model (EuroSCORE II) on a Tunisian population to validate its use in our country.Methods: This is a retrospective study of data from 418 adult patients undergoing cardiac surgery with cardiopulmonary bypass between 1 January 2015 and 31 December 2016 in the department of cardiovascular and thoracic surgery of the Sahloul University Hospital of Sousse. The EuroSCORE ΙΙ is calculated using the application validated on the site www.euroscore.org. The performance of the score is evaluated by analyzing its discriminative power by constructing the receiver operating characteristic (ROC) curve and analyzing its calibration using the Hosmer-Lemeshow statistics.Results: The EuroSCORE II shows good discriminative power in our population with an area under the ROC curve more than 0.7 in all study groups (0.864 ± 0.032 for general cardiac surgery, 0.822 ± 0.061 for coronary surgery, 0.864 ± 0.052 for valvular surgery, and 0.900 ± 0.041 for urgent cardiac surgery). The model appears to be calibrated as well by obtaining P values above the statistical significance level of 0.05 (0.638 for general cardiac surgery, 0.543 for coronary surgery, 0.179 for valvular surgery, and 0.082 for urgent cardiac surgery).Conclusion: The EuroSCORE II presents acceptable performance in our population, attested by a good discriminative power and an adequate calibration. [ABSTRACT FROM AUTHOR]

The concept of biodiesel viewed by pundits as a renewable alternative fuel to diesel engines that could partially or fully replace or reduce the use of petroleum diesel fuel has been gaining great importance worldwide for its good quality exhaust, sustainability and biodegradability. The irregularity in production output, low quality, wastes, and downtimes appears to be a serious production problem being faced by manufacturers of biodiesel products which this study seeks to address. This study seeks to analyze some factors affecting the production process of rubber seed oil based biodiesel using opinion discrimination analysis. The research entails the application of survey method to gather relevant information required to build appropriate data matrix of 31 factors that were used to craft questionnaire administered to 100 respondents for their expert evaluation. Rensis Likert's 5-point attitudinal scale was used in dimensioning the respondent's responses, which were recorded in descending order of rating and were captured in a 100 × 31 data matrix and subsequently analyzed with the use of opinion discriminative analytical tool to obtain the discriminative powers (DP). The result of the DP-values obtained enabled us to appreciate the main factors that significantly influence the rubber seed oil based biodiesel production. In particular their relative influence is indicative of the magnitude of the DP-values. This study has revealed that the opinion discrimination analytical approach employed is effective in dealing with the problem of process variability and degraded output. [ABSTRACT FROM AUTHOR]

Variability in production output, low quality, wastes, and downtimes are serious production problems which manufacturers of alkyd resin product are facing and it invariably affect manufacturers' economic performance and the nation economic growth which are often caused by differences in process temperatures and length of the resin. There is a strong incentive in controlling the end of the batch product property values so as to minimize the variability in product quality. This study seeks to investigate the relationship among variables capable of affecting the production process output of rubber seed oil based alkyd resin. A random survey of relevant literature was conducted to gather relevant information required that are capable of causing a dysfunction in the manufacturing process of rubber seed oil based alkyd resin for use in anti-corrosion paint application. The sensitivity and versatile applicability of opinion discrimination analysis as an off-line tool for dealing with these types of problems was apt. Our result showed that there is a strong relationship between temperature, catalyst, absence of catalyst, length of resin, acidic content, water resistance which can be manipulated to appreciably reduce product degradation and control process variability. Moreover, we showed that opinion discrimination analysis modelling tool can be used to determine the need to understand production process approach for alkyd resin. The study has ably demonstrated that opinion discrimination analytical modelling tool is very effective in fault diagnosis. [ABSTRACT FROM AUTHOR]

Probing food experience or liking through verbal ratings has its shortcomings. We compare explicit ratings to a range of (neuro)physiological and behavioral measures with respect to their performance in distinguishing drinks associated with different emotional experience. Seventy participants tasted and rated the valence and arousal of eight regular drinks and a “ground truth” high-arousal, low-valence vinegar solution. The discriminative power for distinguishing between the vinegar solution and the regular drinks was highest for sip size, followed by valence ratings, arousal ratings, heart rate, skin conductance level, facial expression of “disgust,” pupil diameter, and Electroencephalogram (EEG) frontal alpha asymmetry. Within the regular drinks, a positive correlation was found between rated arousal and heart rate, and a negative correlation between rated arousal and Heart Rate Variability (HRV). Most physiological measures showed consistent temporal patterns over time following the announcement of the drink and taking a sip. This was consistent over all nine drinks, but the peaks were substantially higher for the vinegar solution than for the regular drinks, likely caused by emotion. Our results indicate that implicit variables have the potential to differentiate between drinks associated with different emotional experiences. In addition, this study gives us insight into the physiological temporal response patterns associated with taking a sip.

A myriad of design rules for what constitutes a “good” colormap can be found in the literature. Some common rules include order, uniformity, and high discriminative power. However, the meaning of many of these terms is often ambiguous or open to interpretation. At times, different authors may use the same term to describe different concepts or the same rule is described by varying nomenclature. These ambiguities stand in the way of collaborative work, the design of experiments to assess the characteristics of colormaps, and automated colormap generation. In this paper, we review current and historical guidelines for colormap design. We propose a specified taxonomy and provide unambiguous mathematical definitions for the most common design rules. [ABSTRACT FROM PUBLISHER]

Features act as a key factor in pedestrian detection task. Most widely-used ones like HOG are manually designed and hard to be adaptive, thus now more attention has been paid to the features automatically learned on data. In this paper, a novel approach of learning discriminative features is proposed, addressing two main limitations of the methods in the literature. On one hand, unlike those methods of learning features on low-level pixels, we propose to learn features via a particular sparse coding algorithm enhanced on mid-level image representation, in order to obtain higher-level latent semantics and robustness; On the other hand, those methods usually utilize label information in model training such as deformable part model (DPM) with high computation cost. Instead, we propose to extend the learning process via a maximum margin criterion, in order to better encode discriminative information directly in features by optimizing them to be close to each other if from the same class and far from each other if from different classes. Furthermore, a boosted detection framework rather than the complex DPM is adopted to achieve both high accuracy and efficiency. The proposed approach achieves promising results on several standard pedestrian detection benchmarks. [ABSTRACT FROM AUTHOR]

Soft set theory was originally proposed by Molodtsov in 1999 as a general mathematical tool for dealing with uncertainty. However, it has been pointed out that classical soft set model is not appropriate to deal with imprecise and fuzzy problems. In order to handle these types of problems, some fuzzy extensions of soft set theory are presented, yielding fuzzy soft set theory. As a further research, in this work, we first propose concepts of interval fuzzy sets and interval fuzzy soft sets, define some operations on them and study some of their relevant properties, especially, the dual laws are discussed with respect to difference operation in interval fuzzy soft set theory. We then introduce a revised Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method and choice value method for interval fuzzy soft set which the weight information is completely unknown. Meanwhile, an analysis of computation complexity is employed, also the discriminative power of two methods are shown. Finally, two illustrative examples are employed to show that they can be successfully applied to problems that contain uncertainties. [ABSTRACT FROM AUTHOR]

Background: In order to evaluate the discrimination performance of an ordinal model for improved disease screening, a new test was proposed where information was obtained across all samples simultaneously. Methods: The ordinal c-index builds upon the volume under the surface methodology without focusing on the accompanying receiver operating characteristic surfaces. However, it can be simplified to an average of pairwise c-indexes. In this paper, a set-based estimate (information was obtained across all samples simultaneously) was proposed by summing all correctly ordered groups. The asymptotic distribution of this proposed estimate was derived using U-statistics. Results: A predictive model was applied using the blood urea nitrogen/creatinine ratio to discriminate stroke in evolution in acute ischemic stroke patients, which could potentially be life-saving in emergency departments. Conclusions: By conducting Monte Carlo simulations, it was concluded that the measure proposed herein is a better choice for clinical use because of the asymmetry of the predicted probabilities of groups. [ABSTRACT FROM AUTHOR]

In this paper we will investigate the gradient utilization in building SIFT (Scale Invariant Feature Transform)-like descriptors for image registration. There are generally two types of gradient information, i.e. gradient magnitude and gradient occurrence, which can be used for building SIFT-like descriptors. We will provide a theoretical analysis on the effectiveness of each of the two types of gradient information when used individually. Based on our analysis, we will propose a novel technique which systematically uses both types of gradient information together for image registration. Moreover, we will propose a strategy to select keypoint matches with a higher discrimination. The proposed technique can be used for both mono-modal and multi-modal image registration. Our experimental results show that the proposed technique improves registration accuracy over existing SIFT-like descriptors. [ABSTRACT FROM AUTHOR]

Objectives To compare the discriminative power of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L [5L]) and its three-level version (EQ-5D-3L [3L]) in patients with diabetes in Singapore. Methods A consecutive sample of patients with type 2 diabetes mellitus (T2DM) self-completed the two versions of the EQ-5D in the clinic. The 3L index score was calculated from the Singapore 3L value set, whereas the 5L index score was mapped from the 5L index score using an interim scoring. The discriminative power of the two EQ-5D indices was assessed in terms of their relative efficiency (RE) in differentiating patients with T2DM with and without one of eight clinical conditions. The efficiency of the two EQ-5D classification systems was evaluated using the Shannon’s index ( H׳ ) and in terms of ceiling effects. Results A total of 121 patients with T2DM provided data for this study. The 3L score was systematically higher than the 5L score for patients with T2DM with a condition and systematically lower for the patients without a condition, with the mean differences being 0.005 and −0.011, respectively. The 5L index score showed higher RE in seven of eight clinical conditions (mean RE 1.87). The 5L classification system had higher H׳ in all dimensions: mobility (1.17 vs. 0.70), self-care (0.57 vs. 0.41), usual activities (1.01 vs. 0.72), pain/discomfort (1.47 vs. 1.02), and anxiety/depression (1.36 vs. 1.10). The overall ceiling effects decreased from 47.9% (3L) to 38.8% (5L). Conclusions The EQ-5D-5L is more discriminative than the EQ-5D-3L in patients with T2DM in Singapore, supporting the use of EQ-5D-5L in the population. [ABSTRACT FROM AUTHOR]

Objective:The aim of this study was to determine the relationship between hearing loss and speech reception threshold (SRT) in a fixed noise condition using the German Oldenburg sentence test (OLSA).Design:After training with two easily-audible lists of the OLSA, SRTs were determined monaurally with headphones at a fixed noise level of 65 dB SPL using a standard adaptive procedure, converging to 50% speech intelligibility.Study sample:Data was obtained from 315 ears of 177 subjects with hearing losses ranging from − 5 to 90 dB HL pure-tone average (PTA, 0.5, 1, 2, 3 kHz).Results:Two domains were identified with a linear dependence of SRT on PTA. The SRT increased with a slope of 0.094 ± 0.006 dB SNR/dB HL (standard deviation (SD) of residuals = 1.17 dB) for PTAs < 47 dB HL and with a slope of 0.811 ± 0.049 dB SNR/dB HL (SD of residuals = 5.54 dB) for higher PTAs.Conclusion:The OLSA can be applied to subjects with a wide range of hearing losses. With 65 dB SPL fixed noise presentation level the SRT is determined by listening in noise for PTAs < ∼47 dB HL, and above it is determined by listening in quiet. [ABSTRACT FROM PUBLISHER]

Purpose: To compare the discriminative power of the index scores of EQ-5D-5L (5L) and EQ-5D-3L (3L) in diabetes patients in China. Methods: A consecutive sample of type 2 diabetes mellitus (T2DM) patients in the clinics self-completed the two versions of EQ-5D. The 3L index score was obtained from the Chinese 3L value set; the 5L index score was predicted from the 3L index score using an interim scoring. Relative efficiency (RE) of the 5L and 3L index scores was calculated to compare their ability in differentiating between T2DM patients with and without one of ten clinical conditions. The efficiency of the 5L and 3L health state classification systems was assessed using the Shannon index ( H′) and in terms of ceiling effects. Results: A total of 289 T2DM patients participated in this study. The 5L score was systematically lower than the 3L score for T2DM patients with and without a condition (range −0.36 to −0.06). The 5L score exhibited higher discriminative power in nine of ten conditions, with the mean RE value being 1.92. 5L had higher H′ values than 3L in all the five EQ-5D dimensions: mobility (1.14 vs. 0.70), self-care (0.44 vs. 0.33), usual activities (0.72 vs. 0.47), pain/discomfort (1.58 vs. 1.10), and anxiety/depression (1.03 vs. 0.67). The overall ceiling effects decreased from 56.7 % (3L) to 36.7 % (5L). Conclusion: The 5L index score is more discriminative than the 3L index score in T2DM patients and therefore is preferable for use in this population. [ABSTRACT FROM AUTHOR]

Probing food experience or liking through verbal ratings has its shortcomings. We compare explicit ratings to a range of (neuro)physiological and behavioral measures with respect to their performance in distinguishing drinks associated with different emotional experience. Seventy participants tasted and rated the valence and arousal of eight regular drinks and a "ground truth" high-arousal, low-valence vinegar solution. The discriminative power for distinguishing between the vinegar solution and the regular drinks was highest for sip size, followed by valence ratings, arousal ratings, heart rate, skin conductance level, facial expression of "disgust," pupil diameter, and Electroencephalogram (EEG) frontal alpha asymmetry. Within the regular drinks, a positive correlation was found between rated arousal and heart rate, and a negative correlation between rated arousal and Heart Rate Variability (HRV). Most physiological measures showed consistent temporal patterns over time following the announcement of the drink and taking a sip. This was consistent over all nine drinks, but the peaks were substantially higher for the vinegar solution than for the regular drinks, likely caused by emotion. Our results indicate that implicit variables have the potential to differentiate between drinks associated with different emotional experiences. In addition, this study gives us insight into the physiological temporal response patterns associated with taking a sip. [ABSTRACT FROM AUTHOR]

Background: In order to evaluate the discrimination performance of an ordinal model for improved disease screening, a new test was proposed where information was obtained across all samples simultaneously., Methods: The ordinal c-index builds upon the volume under the surface methodology without focusing on the accompanying receiver operating characteristic surfaces. However, it can be simplified to an average of pairwise c-indexes. In this paper, a set-based estimate (information was obtained across all samples simultaneously) was proposed by summing all correctly ordered groups. The asymptotic distribution of this proposed estimate was derived using U-statistics., Results: A predictive model was applied using the blood urea nitrogen/creatinine ratio to discriminate stroke in evolution in acute ischemic stroke patients, which could potentially be life-saving in emergency departments., Conclusions: By conducting Monte Carlo simulations, it was concluded that the measure proposed herein is a better choice for clinical use because of the asymmetry of the predicted probabilities of groups., (© The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)