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Optimal glycemic control in kidney transplant recipients with diabetes is associated with improved morbidity and better patient and allograft survival. Transplant options for patients with diabetes requiring insulin therapy and chronic kidney disease who are suitable candidates for kidney transplantation should include consideration of beta-cell replacement therapy: pancreas or islet transplantation. International variation related to national regulatory policies exists in offering one or both options to suitable candidates and is further affected by pancreas/islet allocation policies and transplant waiting list dynamics. The selection of appropriate candidates depends on patient age, coexistent morbidities, the timing of referral to the transplant center (predialysis versus on dialysis) and availability of living kidney donors. Therefore, early referral (estimated glomerular filtration rate < 30 mL/min/1.73 m(2)) is of the utmost importance to ensure adequate time for informed decision making and thorough pretransplant evaluation. Obesity, cardiovascular disease, peripheral vascular disease, smoking, and frailty are some of the conditions that need to be addressed before acceptance on the transplant list, and ideally before dialysis becoming imminent. This review offers insights into selection of pancreas/islet transplant candidates by transplant centers and an update on posttransplant outcomes, which may have practice implications for referring nephrologists.

Purpose/Objective(s) Radiation-induced sarcoma (RIS) is a rare secondary malignancy resulting from ionizing radiation-related treatment after a long latency period. Despite the unfavorable clinical outcomes, the genomic footprints of ionizing radiation in RIS development remain largely unknown. Hence, this study aimed to characterize RIS genomes and the genomic alterations in them. Materials/Methods We performed whole-genome sequencing (WGS) of 11 cases of RIS matched with normal genomes to identify somatic alterations potentially associated with RIS development. Results The mutation abundance of RIS genomes including one hypermutated genome was variable. Cancer-related genes might show different types of genomic alterations. For instance, NF1, NF2, NOTCH1, NOTCH2, PIK3CA, RB1, and TP53 showed singleton somatic mutations; MYC, CDKN2A, RB1, and NF1 showed recurrent copy number alterations; and NF2, ARID1B, and RAD51B showed recurrent structural variations (SVs). The effects of non-homologous end joining on short insertions-deletions and SVs were substantial in RIS genomes, compared with in spontaneous osteosarcoma genomes, representing the genomic hallmark of RIS genomes. In addition, frequent chromothripsis and predisposing germline variants in DNA damage-repair pathways were identified. Conclusion Taken together, WGS-scale characterization of RIS genomes may pave the way for advanced diagnostic and therapeutic strategies for RIS.

Scedosporium spp. is the most common mold infection in pneumonia resulting from near-drowning. Three fatal scedosporiosis cases developed after solid organ transplantation, probably transmitted from the nearly-drowned donor. One heart transplant recipient and two kidney transplant recipients developed fatal scedosporiosis following deceased donor transplantation from the same donor, a nearly-drowned victim of a suicide attempt. Genotypically, indistinguishable strains of Scedosporium auratiacum were recovered from the three recipients. Two liver transplant recipients from the same donor received prophylactic voriconazole without any subsequent signs of infection. To determine the safety of donation from nearly-drowned donors, a national traceback investigation was also performed of the causes of deaths in all transplant recipients who received organs from drowned donors between 2001 and 2013. Over 13 years, 2600 deceased donor transplants were performed in Korea. Among these 2600 deceased donor transplants, 27 (1%) victims of drowning donated their organs. From these 27 donors, 84 patients received organ transplants and 18 died, including the above three. We found no microbiologic evidence of invasive mold transmission from the nearly-drowned donors to the other 15 recipients. Although disseminated infection in the donor could not be demonstrated by culture, undiagnosed disseminated donor infection and transmission of Scedosporium spp. should be considered in near-drowning events.

We report experimental realization of lensless imaging on cold rubidium atoms confined in a magneto-optical trap. This imaging scheme relies on the off-resonant light refraction from the cold atoms and is employed in a phase-tunable Mach–Zehnder interferometer, accompanied with phase-shifting interferometry. With this setup, it allows obtaining the probe light phase distribution in the far field after passing the atoms, from which the near-field phase image of the atomic cloud is retrieved using the Fresnel–Kirchhoff integral. We show the phase images can be effectively reconstructed, and the measured two-dimensional phase distributions are in good agreement with the theory.

We have experimentally demonstrated a general method to perform high-precision refractive index spectrum measurement using phase-shifting interferometry in a phase-tunable Mach–Zehnder interferometer. We observed coherent amplification on the refractive spectrum, across the Lamb dips of ground hyperfine states in a Doppler-broadened Rb87 vapor. Most importantly, the spectrum still has a large signal-to-noise ratio when the probe power is in the dark light level under which the method using a single interferogram fails. This experimental scheme is efficient for refractive spectrum measurements and could be extended for 2D phase imaging. It provides many potential applications for optical phase measurements in linear, nonlinear, and quantum optics.

We report experimental observation of large group index across the Lamb dips of ground hyperfine states in Doppler-broadened 87Rb vapor. By sweeping the laser frequency through each hyperfine transition we measure the saturated absorption and optical phase shift using a phase-locked Mach-Zehnder interferometer. Our measurements provide a direct demonstration of the theoretical prediction by Agarwal et al. [G. S. Agarwal and T. N. Dey, Phys. Rev. A 68, 063816, (2003)] for the first time. An enhancement factor as large as 1005 in group index was observed for Rb vapor at temperature of 85 °C. The experimental data are in good agreement with the theory.