46 results on '"Cutaneous ulceration"'
Search Results
2. Acral Cutaneous Ulcerations and Livedo Reticularis with Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Classical Dermatomyositis
- Author
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Rachot Wongjirattikarn, Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Apichart So-ngern, Ajanee Mahakkanukrauh, and Chingching Foocharoen
- Subjects
cutaneous ulceration ,livedo reticularis ,dermatomyositis ,Dermatology ,RL1-803 - Abstract
Rapidly progressive interstitial lung disease (RP-ILD) and its distinctive cutaneous features are highly associated with the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody in patients with dermatomyositis (DM), leading to a poor prognosis. We describe the case of a 25-year-old man who developed progressive proximal muscle weakness with RP-ILD and had unusual cutaneous findings (cutaneous ulcerations and livedo reticularis) accompanied by classical cutaneous features (heliotrope rash, Gottron’s papules, Gottron’s sign, and flagellate erythema). Blood test was positive for anti-MDA5 antibody. He was treated with intravenous corticosteroids and immunoglobulin, but passed away due to respiratory failure within 1 month after admission. Our case highlights that the presence of cutaneous ulcerations and livedo reticularis, in addition to RP-ILD, are useful clinical clues that may aid in the detection of anti-MDA5 antibody, early initiation of combined immunosuppressants, and prognosis prediction in patients with classical DM. more...
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- 2020
- Full Text
- View/download PDF
Catalog
3. Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease.
- Author
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Xu, Antao, Ye, Yan, Fu, Qiong, Lian, Xinyue, Chen, Sheng, Guo, Qiang, Lu, Liang-jing, Dai, Min, Lv, Xia, and Bao, Chunde
- Subjects
- *
AUTOANTIBODIES , *SURVIVAL , *DERMATOMYOSITIS , *IMMUNOGLOBULINS , *INTERSTITIAL lung diseases , *RISK assessment , *IMMUNOBLOTTING , *DENSITOMETRY , *PHENOTYPES , *DISEASE risk factors , *DISEASE complications , *ADULTS - Abstract
Objective Anti-Ro52 antibody often co-occurs with anti-Jo1 antibody in antisynthetase syndrome and their co-occurrence correlates with a more aggressive clinical phenotype and poorer prognosis. The strong association of anti-Ro52 antibody with anti-melanoma differentiation-associated protein-5 (anti-MDA5) antibody has been indicated in juvenile myositis. The aim of this study was to assess the clinical significance of anti-Ro52 antibody in a cohort of adult patients with anti-MDA5-positive clinically amyopathic dermatomyositis with interstitial lung disease (CADM-ILD). Methods We assessed a cohort of 83 consecutive patients with anti-MDA5-positive CADM-ILD. Anti-MDA5 antibodies and anti-Ro52 antibodies were detected in immunoblotting and semi-quantitatively analysed by densitometry. Clinical features and the 24 month survival were compared between anti-MDA5-positive patients with and without anti-Ro52 antibodies. Results Anti-Ro52 antibodies were found in 74.7% of anti-MDA5-positive CADM-ILD patients and were associated with an increased frequency of rapidly progressive interstitial lung disease (RP-ILD; 54.8% vs 23.8%; P = 0.014) and cutaneous ulcerations (27.4% vs 4.8%; P = 0.033). The cumulative 24 month survival rate tended to be lower in patients with anti-Ro52 antibodies than patients without (59.9% vs 85.7%; P = 0.051). The combination of anti-Ro52 antibody status and anti-MDA5 antibody levels further stratified patients' survival rates, showing that the survival rate of patients who were dual positive for anti-MDA5 antibody and anti-Ro52 antibody was significantly lower than patients with mild positive anti-MDA5 antibody alone (59.9% vs 100%; P = 0.019). Conclusion Anti-Ro52 antibody is highly prevalent in anti-MDA5-positive CADM-ILD patients and their coexistence correlates with a subgroup of patients with more aggressive phenotypes. The combination of anti-MDA5 antibody levels and anti-Ro52 antibody status could help to predict patients' prognosis and guide risk-based therapy. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
4. Acral Cutaneous Ulcerations and Livedo Reticularis with Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Classical Dermatomyositis.
- Author
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Wongjirattikarn, Rachot, Chaowattanapanit, Suteeraporn, Choonhakarn, Charoen, So-ngern, Apichart, Mahakkanukrauh, Ajanee, and Foocharoen, Chingching
- Subjects
DERMATOMYOSITIS ,MUSCLE weakness ,INTERSTITIAL lung diseases ,RESPIRATORY insufficiency ,BLOOD testing ,FORECASTING ,MELANOMA - Abstract
Rapidly progressive interstitial lung disease (RP-ILD) and its distinctive cutaneous features are highly associated with the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody in patients with dermatomyositis (DM), leading to a poor prognosis. We describe the case of a 25-year-old man who developed progressive proximal muscle weakness with RP-ILD and had unusual cutaneous findings (cutaneous ulcerations and livedo reticularis) accompanied by classical cutaneous features (heliotrope rash, Gottron's papules, Gottron's sign, and flagellate erythema). Blood test was positive for anti-MDA5 antibody. He was treated with intravenous corticosteroids and immunoglobulin, but passed away due to respiratory failure within 1 month after admission. Our case highlights that the presence of cutaneous ulcerations and livedo reticularis, in addition to RP-ILD, are useful clinical clues that may aid in the detection of anti-MDA5 antibody, early initiation of combined immunosuppressants, and prognosis prediction in patients with classical DM. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
5. Efficacy and safety of platelet‐rich plasma in treating cutaneous ulceration: A meta‐analysis of randomized controlled trials.
- Author
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Shen, Zhen, Chen, Guoqian, Li, Ding, Zheng, Shengpeng, Jiang, Ziwei, Li, Yue, and Huang, Feng
- Subjects
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PLATELET-rich plasma , *RANDOMIZED controlled trials , *PRESSURE ulcers , *META-analysis - Abstract
Summary: Background: The biological mechanisms underlying the use of platelet‐rich plasma (PRP), as well as the efficacy and possible adverse effects of PRP, have not yet been fully elucidated. Prior studies have evaluated PRP for cutaneous ulceration. However, the benefits from PRP still remain controversial and few have assessed the effects of ulceration etiologies. The purpose of our study is to determine the efficacy and safety of PRP and which kind of ulcer is more suitable for PRP by analyzing the effects of PRP on ulcers with different causes. Methods: A comprehensive search was performed to identify randomized controlled trials (RCTs) regarding the application of PRP from PubMed, EMBASE, Scopus, and the Cochrane Library. The data were analyzed using Review Manager 5.3. Results: A total of nineteen RCTs (909 patients) were included. In contrast with conventional treatments, PRP achieved higher healing rate, higher percentage of area reduction, and smaller final area in vascular ulcers. However, the advantage disappeared in diabetic and pressure ulcers. Concerning adverse events, PRP showed lower incidence in the short term, but higher in the long term. No significant differences were found in ulcer closure velocity and healing time. Conclusion: Platelet‐rich plasma effectiveness and safety in treating cutaneous ulceration depend on what is the ulceration etiology. For diabetic ulcers, PRP showed no satisfactory results suggesting that PRP may not be suitable for diabetic patients. However, PRP could be efficient and more beneficial for vascular ulcers and effects on pressure ulcers remain unclear. Thus, PRP option should be carefully considered for each patient in accordance with their ulceration etiologies. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
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6. Unusual Clinical Presentations in Early-Onset Childhood Sarcoidosis: A Correlation or Coincidence?
- Author
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Priyadarshini Sahu, Sudhanshu Sharma, Nidhi Sharma, Sarika Sharma, and Shilpa Garg
- Subjects
cutaneous ulceration ,early onset childhood sarcoidosis ,geographical tongue ,onycholysis ,Medicine - Abstract
Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i.e., 13–15 years. Early onset sarcoidosis ( more...
- Published
- 2017
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7. Methotrexate-induced cutaneous ulceration without pancytopenia in a patient treated for inflammatory arthritis
- Author
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Ronald Berna, Diego Ruiz Dasilva, George X. Xu, and Emily Baumrin
- Subjects
rheumatoid arthritis ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Inflammatory arthritis ,RA, rheumatoid arthritis ,Case Report ,Dermatology ,medicine.disease ,Pancytopenia ,methotrexate ,RA - Rheumatoid arthritis ,drug reaction ,Rheumatoid arthritis ,RL1-803 ,medicine ,Methotrexate ,Drug reaction ,MTX - Methotrexate ,business ,MTX, methotrexate ,inflammatory arthritis ,medicine.drug - Published
- 2021
8. Methotrexate-induced cutaneous ulceration and necrosis in chronic atopic dermatitis
- Author
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Malika A. Ladha, Vimal H. Prajapati, Jonathan Levy, Bryn Edgerton, Alim Devani, Parbeer Grewal, and Muhammad N. Mahmood
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medicine.medical_specialty ,Necrosis ,Cutaneous ulceration ,business.industry ,Case Report ,Dermatology ,Atopic dermatitis ,lcsh:RL1-803 ,medicine.disease_cause ,medicine.disease ,Herpes simplex virus ,lcsh:Dermatology ,medicine ,HSV, herpes simplex virus ,Methotrexate ,medicine.symptom ,business ,medicine.drug - Published
- 2020
- Full Text
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9. Acral Cutaneous Ulcerations and Livedo Reticularis with Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Classical Dermatomyositis
- Author
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Suteeraporn Chaowattanapanit, Rachot Wongjirattikarn, Apichart So-ngern, Charoen Choonhakarn, Chingching Foocharoen, and Ajanee Mahakkanukrauh
- Subjects
medicine.medical_specialty ,dermatomyositis ,Single Case ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,lcsh:Dermatology ,Blood test ,Progressive proximal muscle weakness ,Livedo reticularis ,medicine.diagnostic_test ,biology ,business.industry ,Interstitial lung disease ,livedo reticularis ,Heliotrope rash ,Dermatomyositis ,cutaneous ulceration ,lcsh:RL1-803 ,medicine.disease ,Respiratory failure ,030220 oncology & carcinogenesis ,biology.protein ,medicine.symptom ,Antibody ,business - Abstract
Rapidly progressive interstitial lung disease (RP-ILD) and its distinctive cutaneous features are highly associated with the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody in patients with dermatomyositis (DM), leading to a poor prognosis. We describe the case of a 25-year-old man who developed progressive proximal muscle weakness with RP-ILD and had unusual cutaneous findings (cutaneous ulcerations and livedo reticularis) accompanied by classical cutaneous features (heliotrope rash, Gottron’s papules, Gottron’s sign, and flagellate erythema). Blood test was positive for anti-MDA5 antibody. He was treated with intravenous corticosteroids and immunoglobulin, but passed away due to respiratory failure within 1 month after admission. Our case highlights that the presence of cutaneous ulcerations and livedo reticularis, in addition to RP-ILD, are useful clinical clues that may aid in the detection of anti-MDA5 antibody, early initiation of combined immunosuppressants, and prognosis prediction in patients with classical DM. more...
- Published
- 2020
10. Late onset leflunomide-induced cutaneous ulcers in a seronegative arthritis patient: A case report.
- Author
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Couture-Lapointe C, Grenier PO, Bessette L, and Veillette H
- Abstract
The differential diagnosis for chronic cutaneous ulcers is wide. Once the common causes have been excluded, infrequent ones, including drugs, should be considered. We report the case of a 67 year old woman with multiple ulcers not responding to conventional treatment. Multiple investigations including laboratory testing, skin biopsies and tissue cultures were negative. A few cases of leflunomide-induced cutaneous ulcers are reported in the literature. Our patient was on this drug for 12 years. Discontinuation of leflunomide led to ulcers resolution. This is the longest reported time interval between leflunomide initiation and ulceration onset., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.) more...
- Published
- 2023
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11. Ulcérations des extrémités : une manifestation inhabituelle de la maladie de Behçet.
- Author
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Mejri, M., Said, F., Khanfir, M., Chelly, I., Haouet, S., and Habib, H.
- Abstract
Résumé Introduction Bien que l'atteinte cutanéomuqueuse soit une manifestation principale dans la maladie de Behçet, les lésions ulcérées des extrémités sont exceptionnelles et peu connues. Observation Un patient de sexe masculin âgé de 57 ans était suivi depuis 7 ans pour une maladie de Behçet, diagnostiquée devant une aphtose buccale bipolaire récidivante, des lésions de pseudofolliculite et une vascularite rétinienne. Après avoir été perdu de vue et avoir suspendu le traitement pendant deux ans, il consultait pour des ulcérations nécrotiques centimétriques des doigts des mains et du gros orteil droit. La biopsie des lésions montrait des lésions de vascularite leucocytoclasique et nécrosante. Le patient était traité par antibiothérapie, corticothérapie orale, colchicine et soins locaux, permettant une bonne évolution. Conclusion Établir le lien entre ulcérations des extrémités et maladie de Behçet, bien que parfois difficile, est indispensable pour une prise en charge appropriée. Abstract Background Although cutaneous and mucosal involvement is a major manifestation in Behçet's disease, ulcerated lesions of the extremities are exceptional and poorly known. Case report A 57-year-old male patient was diagnosed 7 years ago with Behçet's disease. This diagnosis was made in the presence of recurrent bipolar aphtous ulcers, pseudofolliculitis lesions and retinal vasculitis. After having been lost to follow up for two years, during which his treatment was discontinued, he presented centimetric necrotic ulcerations of the fingers of the hand and of the right big toe. The biopsy revealed leucocytoclastic and necrotizing vasculitis. The patient improved with antibiotic, oral corticosteroids, colchicine and local care. Conclusion Linking extremity ulcers with Behçet's disease, though sometimes difficult, is essential for proper management. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
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12. Methotrexate Cutaneous Toxicity following a Single Dose of 10 mg in a Case of Chronic Plaque Psoriasis: A Possible Idiosyncratic Reaction.
- Author
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Gupta, Aastha, Sardana, Kabir, Bhardwaj, Minakshi, and Singh, Ajeet
- Subjects
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METHOTREXATE , *PSORIASIS treatment , *DRUG side effects - Abstract
Low-dose methotrexate is a well-tolerated and inexpensive systemic immunosuppressive agent used commonly in dermatology. However, several adverse events such as pancytopenia, pneumonitis, mucositis, and cutaneous ulcerations may develop during acute toxicity with dose.dependent or idiosyncratic mechanisms. Risk factors for methotrexate toxicity include advanced age, hypoalbuminemia, renal dysfunction, and concomitant drugs increasing the level of methotrexate in the body. We present a case of methotrexate toxicity presenting with classical features along with mucocutaneous side-effects, such as ulceration of psoriatic plaques and acral erythema, following a single dose of methotrexate. [ABSTRACT FROM AUTHOR] more...
- Published
- 2018
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13. A case of peristomal cutaneous ulceration
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Laura Wheller, Tania Zappala, Sarath Bodapati, Tristan Blake, and Yolanka Lobo
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medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Peritoneal Stomata ,Middle Aged ,Dermatology ,Pyoderma Gangrenosum ,Postoperative Complications ,medicine ,Humans ,Female ,Family Practice ,business ,Ulcer - Published
- 2020
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14. The rashes that lead to cutaneous ulcers
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Marcia Ramos-e-Silva, Amanda Pedreira Nunes, and Sueli Carneiro
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Vasculitis ,medicine.medical_specialty ,Cutaneous ulceration ,Paraneoplastic Syndromes ,Hepatosplenomegaly ,Dermatology ,Infections ,Autoimmune Diseases ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Skin Ulcer ,Parasitic Diseases ,medicine ,Humans ,Exanthem ,030203 arthritis & rheumatology ,Granuloma ,Skin Diseases, Vesiculobullous ,business.industry ,Exanthema ,medicine.disease ,Sweet Syndrome ,Rash ,Cutaneous ulcers ,Drug Hypersensitivity Syndrome ,Etiology ,medicine.symptom ,business - Abstract
Skin rashes have exanthema as a synonym, a term derived from the Greek words exanthem, meaning "to appear," and anthos, which denotes "flourishing." The relevant factors for characterization of a rash include distribution, configuration, and organization of the lesions, in addition to evidence of systemic involvement through toxemia, adenopathy, and conjunctive lesions, hepatosplenomegaly, excoriations or phlogosis, neck rigidity, or neurologic dysfunction. A rash may evolve to cutaneous ulceration in many instances, which is relevant for the diagnosis, the followup, and the therapeutic management of the patient. Systemic diseases with exanthemas that result in ulcerations prevail over diseases that are restricted to signs and/or merely cutaneous clinical manifestations. A variety of etiologies can present cutaneous rashes with ulcers, subject or not to systemic involvement by the underlying disease, among which stand out the bullous diseases, infectious and parasitic diseases, noninfectious granulomatous diseases, vasculitis, paraneoplastic syndromes, autoimmune diseases of the connective tissue, neutrophilic diseases, lichen planus, and drug hypersensitivity syndrome. The authors present a detailed review of some diseases corresponding to each one of the mentioned etiologies, updating the clinical manifestations and therapeutic proposals. more...
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- 2020
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15. Pyoderma gangrenosum – a guide to diagnosis and management
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Florence Deroide, Christina George, and Malcolm H.A. Rustin
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Delayed wound healing ,medicine.medical_specialty ,Inflammatory dermatosis ,Cutaneous ulceration ,business.industry ,Horizons in Medicine ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Dermatology ,Pyoderma Gangrenosum ,Diagnosis, Differential ,Lesion ,03 medical and health sciences ,Early Diagnosis ,0302 clinical medicine ,Neutrophilic dermatosis ,Humans ,Medicine ,030212 general & internal medicine ,Differential diagnosis ,medicine.symptom ,business ,Pyoderma gangrenosum - Abstract
Pyoderma gangrenosum (PG) is a reactive non-infectious inflammatory dermatosis falling under the spectrum of the neutrophilic dermatoses. There are several subtypes, with ‘classical PG’ as the most common form in approximately 85% cases. This presents as an extremely painful erythematous lesion which rapidly progresses to a blistered or necrotic ulcer. There is often a ragged undermined edge with a violaceous/erythematous border. The lower legs are most frequently affected although PG can present at any body site. Other subtypes include bullous, vegetative, pustular, peristomal and superficial granulomatous variants. The differential diagnosis includes all other causes of cutaneous ulceration as there are no definitive laboratory or histopathological criteria for PG. Underlying systemic conditions are found in up to 50% of cases and thus clinicians should investigate thoroughly for such conditions once a diagnosis of PG has been made. Treatment of PG remains largely anecdotal, with no national or international guidelines, and is selected according to severity and rate of progression. Despite being a well-recognised condition, there is often a failure to make an early diagnosis of PG. This diagnosis should be actively considered when assessing ulcers, as prompt treatment may avoid the complications of prolonged systemic therapy, delayed wound healing and scarring. more...
- Published
- 2019
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16. Cutaneous ulceration as primary presentation of TEMPI syndrome
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Christoph Sinz, Georg Stary, J. Strobl, Wolfgang Weninger, and Peter Maximilian Heil
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medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Paraproteinemias ,Polycythemia ,Dermatology ,medicine.disease ,Infectious Diseases ,TEMPI syndrome ,Humans ,Medicine ,Telangiectasis ,Presentation (obstetrics) ,business - Published
- 2021
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17. The Spectrum of Cutaneous Reactive Angiomatoses in End Stage Renal Failure
- Author
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Gorav Neel Wali, Radhika Bali, and Eleni Ieremia
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Pathology ,medicine.medical_specialty ,Angiomatosis ,Cutaneous ulceration ,Context (language use) ,Dermatology ,urologic and male genital diseases ,Skin Diseases ,Pathology and Forensic Medicine ,Necrosis ,Fatal Outcome ,Skin Ulcer ,medicine ,Humans ,Clinical significance ,Vascular proliferation ,Skin ,Calciphylaxis ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Angiomatoses ,End stage renal failure ,Blood Vessels ,Kidney Failure, Chronic ,Female ,business - Abstract
Cutaneous reactive angiomatoses encompass a spectrum of conditions driven by underlying occlusive vasculopathy. We present 2 cases of reactive angioproliferation in the context of end-stage renal failure (ESRF) manifesting as painful cutaneous ulceration. The first case demonstrates histologic features of diffuse dermal angiomatosis. The second case illustrates a nonspecific pattern of vascular proliferation which does not conform to any of the classically described subtypes, therefore reinforcing the concept of a spectrum of histopathologic changes in reactive angioproliferations. Diffuse dermal angiomatosis has been described in ESRF alone and in association with calciphylaxis, a life-threatening condition. Recognizing the patterns of reactive angioproliferation in the context of ESRF therefore has clinical relevance. Earlier identification may facilitate mitigation of risk factors and improve prognosis. more...
- Published
- 2021
18. Unusual Clinical Presentations in Early-Onset Childhood Sarcoidosis: A Co-Relation or Co-Incidence?
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SAHU, PRIYADARSHINI, SHARMA, SUDHANSHU, SHARMA, NIDHI, SHARMA, SARIKA, and GARG, SHILPA
- Subjects
SKIN ulcers ,ARTHRITIS - Abstract
Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i.e., 13-15 years. Early onset sarcoidosis (<5 years) is characterized by a triad of arthritis, uveitis and rash. Late onset sarcoidosis present with a multisystem disease similar to adults, with frequent pulmonary infiltrations and lymphadenopathy. Herein, we report a case of early-onset childhood sarcoidosis in a four-year-old female along with uncommon clinical features like cutaneous ulceration, onycholysis and geographical tongue and its rarity in the literature. [ABSTRACT FROM AUTHOR] more...
- Published
- 2017
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19. Cutaneous ulceration and digital gangrene in an anti-MDA5-positive overlap myositis
- Author
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Fang Du, Xia Lv, Min Dai, and Antao Xu
- Subjects
Gangrene ,medicine.medical_specialty ,Cutaneous ulceration ,Interferon-Induced Helicase, IFIH1 ,Myositis ,business.industry ,MEDLINE ,Middle Aged ,medicine.disease ,Dermatology ,Fingers ,Rheumatology ,Skin Ulcer ,Medicine ,Humans ,Pharmacology (medical) ,Female ,business ,Autoantibodies - Published
- 2020
20. Radiation Recall Dermatitis After the Use of Pralatrexate for Peripheral T-cell Lymphoma
- Author
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R.S. Bhangoo, William W. Wong, Munveer S. Bhangoo, and Aaron R. Mangold
- Subjects
medicine.medical_specialty ,Cutaneous ulceration ,Lymphoma ,business.industry ,medicine.medical_treatment ,Pralatrexate ,medicine.disease ,Dermatology ,eye diseases ,Peripheral T-cell lymphoma ,030218 nuclear medicine & medical imaging ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,Radiation Recall Dermatitis ,Oncology ,Palliative radiotherapy ,030220 oncology & carcinogenesis ,medicine ,Radiology, Nuclear Medicine and imaging ,Methotrexate ,business ,medicine.drug - Abstract
Radiation recall dermatitis (RRD) is a well-known but poorly understood phenomenon. RRD is an inflammatory reaction of the skin that occurs in a previously irradiated area shortly after the administration of a systemic agent. Although many chemotherapeutic drugs, including anti-folates, have been associated with RRD, there has been no published report of such interaction between radiation (RT) and pralatrexate. We report a case of palliative radiotherapy delivered in between cycles of pralatrexate thearpy for peripheral T-cell lymphoma (PTCL) resulting in cutaneous ulceration (grade 3 skin toxicity) of previously irradiated lateral left hip and anterior left thigh regions. This case represents the first reported case of pralatrexate associated RRD. Clinicians across disciplines should be aware of the possibility of RRD when pralatrexate is administered after radiotherapy. more...
- Published
- 2018
21. The challenge of establishing treatment efficacy for cutaneous vascular manifestations of systemic sclerosis
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John D Pauling
- Subjects
medicine.medical_specialty ,Cutaneous ulceration ,Raynaud’s phenomenon ,Immunology ,Ischemia ,outcome measures ,03 medical and health sciences ,0302 clinical medicine ,Skin Ulcer ,critical digital ischaemia ,medicine ,Humans ,Immunology and Allergy ,Vascular Diseases ,cardiovascular diseases ,030212 general & internal medicine ,telangiectasia ,skin and connective tissue diseases ,Telangiectasia ,digital ulceration ,030203 arthritis & rheumatology ,clinical trials ,Scleroderma, Systemic ,integumentary system ,business.industry ,Outcome measures ,medicine.disease ,Dermatology ,Treatment efficacy ,Clinical trial ,Systemic sclerosis ,medicine.symptom ,business - Abstract
INTRODUCTION: The cutaneous vascular manifestations of systemic sclerosis (SSc) comprise Raynaud's phenomenon, cutaneous ulceration, telangiectasia formation and critical digital ischaemia; each of which are associated with significant disease-related morbidity. Despite the availability of multiple classes of vasodilator therapy, many of which have been the subject of RCTs, a limited number of pharmacological interventions are currently approved for the management of cutaneous vascular manifestations of SSc. Areas covered: A major challenge has been demonstrating treatment efficacy with examples of promising therapies yielding contrasting results in controlled trial settings. Differences between consensus best-practice guidelines, evidence-based recommendations and marketing approvals in different jurisdictions has resulted in geographic variation in clinical practice concerning the management of cutaneous vascular manifestations of SSc. Difficulty demonstrating treatment efficacy risks waning industry engagement for drug development programmes in this field. This article highlights the key challenges in establishing treatment efficacy and barriers that must be overcome to support successful clinical trial programmes across the spectrum of cutaneous vascular manifestations of SSc. Expert commentary: The paucity of approved treatments for cutaneous vascular manifestations of SSc relates as much to challenges in clinical trial design and the need for reliable clinical trial endpoints, as to lack of therapeutic options. more...
- Published
- 2018
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22. Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect
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Amy Musiek, Hal Lewis, Kathleen M. Nemer, and Rebecca Chibnall
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medicine.medical_specialty ,Cutaneous ulceration ,Side effect ,RA, rheumatoid arthritis ,Dermatology ,methotrexate ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Dermatology ,Medicine ,Case Series ,MTX, methotrexate ,ulcers ,030203 arthritis & rheumatology ,business.industry ,cutaneous ,toxicity ,lcsh:RL1-803 ,medicine.disease ,RA - Rheumatoid arthritis ,Rheumatoid arthritis ,Toxicity ,Methotrexate ,MTX - Methotrexate ,business ,H&E, hematoxylin-eosin stain ,medicine.drug - Published
- 2017
23. Cutaneous ulceration in an infant
- Author
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Albert Casulleras González, Cristina López Llunell, Jesús Luelmo Aguilar, Patricia Garbayo Salmons, and Miquel Casals Andreu
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Male ,medicine.medical_specialty ,Cutaneous ulceration ,Skin Neoplasms ,Treatment outcome ,MEDLINE ,Dermatology ,Severity of Illness Index ,Diagnosis, Differential ,Text mining ,Pharmacotherapy ,Rare Diseases ,Recurrence ,Severity of illness ,Biopsy ,Skin Ulcer ,medicine ,Humans ,Leg ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Follow up studies ,Infant ,Immunohistochemistry ,Pyoderma Gangrenosum ,Anti-Bacterial Agents ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Buttocks ,Drug Therapy, Combination ,Steroids ,business ,Follow-Up Studies - Published
- 2019
24. A rare cause of cutaneous ulceration: Prolidase deficiency
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Duygu Gülseren, Serap Sivri, Gonca Elçin, Artoghrul lsazade, Özay Gököz, Diclehan Orhan, Ayşen Karaduman, Berrak Bilginer Gürbüz, and Sibel Dogan
- Subjects
medicine.medical_specialty ,Prolidase deficiency ,Cutaneous ulceration ,business.industry ,Treatment outcome ,MEDLINE ,Dermatology ,medicine.disease ,medicine ,Surgery ,Young adult ,Letters to the Editor ,business - Published
- 2019
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25. Cutaneous ulceration scattering induced topically by cannabidiol oil in the laboratory animal
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F Hernández-Martínez, A Santana-del-Pino, B-C Rodríguez-de-Vera, J-F Jiménez-Díaz, and C Jiménez-Rodríguez
- Subjects
medicine.medical_specialty ,Cutaneous ulceration ,CANNABIDIOL OIL ,Animals laboratory ,business.industry ,Public Health, Environmental and Occupational Health ,medicine ,Skin ulcer ,medicine.symptom ,business ,Cannabidiol ,Dermatology ,medicine.drug - Published
- 2019
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26. An unusual cause of cutaneous ulceration
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B. Bovill, E. M. Johnson, D. Shipley, Y. Ng, Nidhi Bhatt, and Christina Wlodek
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Male ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Prednisolone ,Cryptococcosis ,Dermatology ,Diagnosis, Differential ,Immunocompromised Host ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Skin Ulcer ,Cryptococcus neoformans ,medicine ,Humans ,Skin pathology ,business ,Glucocorticoids ,030217 neurology & neurosurgery ,Aged ,Skin - Published
- 2017
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27. Pathology of finfish and mud crabs Scylla serrata during a mortality event associated with a harbour development project in Port Curtis, Australia
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R Faulder, B K Diggles, L Olyott, M Landos, Michelle M. Dennis, G E Gilbert, and S B Pyecroft
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0106 biological sciences ,Cutaneous ulceration ,Brachyura ,Range (biology) ,Parasitism ,010501 environmental sciences ,Aquatic Science ,01 natural sciences ,Scylla serrata ,medicine ,Animals ,Humans ,Industry ,Water Pollutants ,Ships ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences ,computer.programming_language ,biology ,010604 marine biology & hydrobiology ,Corneal opacity ,Australia ,Fishes ,biology.organism_classification ,medicine.disease ,Crustacean ,Fishery ,Harbour ,Ulcerative dermatitis ,computer ,Environmental Monitoring - Abstract
The objective of this study was to assess the extent and describe the nature of a multi-species marine finfish and crustacean disease event that occurred in Gladstone Harbour, Australia, 2011-2012. Finfish were examined for this study in January to April 2012 from sites where diseased animals were previously observed by the public. Gross abnormalities, including excessive skin and gill mucus, erythema, heavy ecto-parasitism, cutaneous ulceration, corneal opacity, and exophthalmos, were higher (25.5%) in finfish from Gladstone Harbour (n = 435) than in those from an undeveloped reference site, 250 km to the north (5.5%, n = 146, p < 0.0001). Microscopic abnormalities, especially non-infectious erosive to ulcerative dermatitis and internal parasitism, were more prevalent in fish from Gladstone Harbour (n = 34 of 36, prevalence = 94.4%) than in fish from the reference site (3 of 23, prevalence = 13.0% p < 0.0001). The prevalence of shell lesions was higher in mud crabs Scylla serrata sampled from Gladstone Harbour (270 of 718, prevalence = 37.5%) than from the reference site (21 of 153, prevalence = 13.7%; p < 0.0001). The significantly higher prevalence of ulcerative skin disease and parasitism in a range of species suggests affected animals were subjected to influences in Gladstone Harbour that were not present in the control sites. The disease epidemic coincided temporally and spatially with water quality changes caused by a harbour development project. The unique hydrology, geology, and industrial history of the harbour, the scope of the development of the project, and the failure of a bund wall built to retain dredge spoil sediment were important factors contributing to this epidemic. more...
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- 2016
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28. Nicorandil-induced penile ulcerations: A case report and review of the penile cutaneous circulation
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M. Ng, C.D. Jones, and Arup Ray
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Dorsum ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,lcsh:Surgery ,lcsh:RD1-811 ,Clinical manifestation ,030230 surgery ,digestive system diseases ,Surgery ,Nicorandil ,03 medical and health sciences ,0302 clinical medicine ,medicine ,cardiovascular system ,Ulceration ,030212 general & internal medicine ,PENILE ULCERATION ,business ,medicine.drug - Abstract
Mucosal and cutaneous ulceration as a result of nicorandil use is well described in the literature. Nicorandil induced penile ulceration is a rare clinical manifestation. Six cases arising from either the dorsal or lateral prepuce have been reported in current literature. We present a case of nicorandil induced penile ulceration affecting the dorsolateral prepuce and give an overview of the penile cutaneous circulation. more...
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- 2016
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29. Persistent cutaneous ulcers after Yttrium-90 synovectomy, an unusual complication: two case reports and a review of the literature
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Jordi Monfort, Lidia García-Colmenero, Ramon M. Pujol, and Gemma Martin-Ezquerra
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musculoskeletal diseases ,030203 arthritis & rheumatology ,medicine.medical_specialty ,Cutaneous ulceration ,Side effect ,business.industry ,medicine.medical_treatment ,Synovectomy ,Dermatology ,Osteoarthritis ,medicine.disease ,030218 nuclear medicine & medical imaging ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Cutaneous ulcers ,Rheumatoid arthritis ,Synovitis ,medicine ,Complication ,business - Abstract
Development of persistent deep cutaneous ulceration is a rare and serious complication of radiosynovectomy, an extended procedure used in the treatment of chronic synovitis. Cutaneous radiation necrosis is a rare complication of synovectomy, probably as a result of radiocolloid para-articular injection. This rare phenomenon should be suspected when an ulcer adjacent to an articulation appears several days or even months after a radiation synovectomy. It can turn into a challenging diagnosis for rheumatologists, orthopaedists and dermatologists, especially in those cases with a late development of the skin lesions. Recognition of this potential side effect is important in order to establish a proper therapeutic strategy and avoid unnecessary treatments. Surgical excision appears to be the treatment of choice. We report two patients with knee osteoarthritis treated with intra-articular injection of Yttrium-90 who developed persistent cutaneous ulcers secondary to radiation necrosis. more...
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- 2016
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30. Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report
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S. Bhuvaneshwari T. Shanmugham, Vinay Singh Raghuvanshi, and C Dinesh M Naidu
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Methotrexate treatment ,Drug ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,media_common.quotation_subject ,medicine.disease ,Dermatology ,Toxic epidermal necrolysis ,Concomitant ,Psoriasis ,Toxicity ,medicine ,Methotrexate ,business ,media_common ,medicine.drug - Abstract
Methotrexate continues to be one of the most widely used systemic immunosuppressive agents in dermatology. We describe a case of low-dose methotrexate (MTX) toxicity in a patient with chronic plaque psoriasis occurring during long-standing methotrexate therapy. This case report emphasizes the fact that co-medications like NSAIDS may exacerbate MTX toxicity. This patient had a rare methotrexate-induced toxic epidermal necrolysis including cutaneous ulceration. Hence, careful consideration of concomitant medication is required to avoid drug interactions for safe long-term methotrexate treatment. more...
- Published
- 2017
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31. Úlceras cutáneas en paciente con dermatomiositis amiopática anti-MDA5 positivo
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Alberto Andamoyo Castañeda, Iván Pérez de Pedro, Leandro Martínez Pilar, and Elisabeth Gómez Moyano
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medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,medicine ,General Medicine ,Dermatomyositis ,medicine.disease ,Anti mda5 antibody ,business ,Dermatology - Published
- 2020
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32. Cutaneous ulceration: A sign of methotrexate toxicity in oral cancer patient
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Navin Kumar, Deepika Mishra, Sandeep Bhoriwal, and S.V.S. Deo
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Cancer Research ,medicine.medical_specialty ,Cutaneous ulceration ,Oncology ,Methotrexate Toxicity ,business.industry ,medicine ,Cancer ,Oral Surgery ,business ,medicine.disease ,Dermatology ,Sign (mathematics) - Published
- 2020
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33. Efficacy and safety of platelet-rich plasma in treating cutaneous ulceration: A meta-analysis of randomized controlled trials
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Zhen Shen, Feng Huang, Shengpeng Zheng, Yue Li, Guoqian Chen, Ziwei Jiang, and Ding Li
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medicine.medical_specialty ,Cutaneous ulceration ,Time Factors ,animal diseases ,Dermatology ,Cochrane Library ,Gastroenterology ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Skin Ulcer ,medicine ,Humans ,Adverse effect ,Randomized Controlled Trials as Topic ,Wound Healing ,business.industry ,Platelet-Rich Plasma ,% area reduction ,digestive system diseases ,Diabetic Foot ,nervous system diseases ,Treatment Outcome ,030220 oncology & carcinogenesis ,Meta-analysis ,Platelet-rich plasma ,Etiology ,business - Abstract
Background The biological mechanisms underlying the use of platelet-rich plasma (PRP), as well as the efficacy and possible adverse effects of PRP, have not yet been fully elucidated. Prior studies have evaluated PRP for cutaneous ulceration. However, the benefits from PRP still remain controversial and few have assessed the effects of ulceration etiologies. The purpose of our study is to determine the efficacy and safety of PRP and which kind of ulcer is more suitable for PRP by analyzing the effects of PRP on ulcers with different causes. Methods A comprehensive search was performed to identify randomized controlled trials (RCTs) regarding the application of PRP from PubMed, EMBASE, Scopus, and the Cochrane Library. The data were analyzed using Review Manager 5.3. Results A total of nineteen RCTs (909 patients) were included. In contrast with conventional treatments, PRP achieved higher healing rate, higher percentage of area reduction, and smaller final area in vascular ulcers. However, the advantage disappeared in diabetic and pressure ulcers. Concerning adverse events, PRP showed lower incidence in the short term, but higher in the long term. No significant differences were found in ulcer closure velocity and healing time. Conclusion Platelet-rich plasma effectiveness and safety in treating cutaneous ulceration depend on what is the ulceration etiology. For diabetic ulcers, PRP showed no satisfactory results suggesting that PRP may not be suitable for diabetic patients. However, PRP could be efficient and more beneficial for vascular ulcers and effects on pressure ulcers remain unclear. Thus, PRP option should be carefully considered for each patient in accordance with their ulceration etiologies. more...
- Published
- 2018
34. Muco‒cutaneous ulceration induced by low doses of methotrexate
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Prince Yuvraj Matharu, Deepak Vashisht, and Sukriti Baveja
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Immunodermatology ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Low dose ,Acne treatment ,medicine.disease ,Dermatology ,Eyelid surgery ,Psoriasis ,medicine ,Methotrexate ,Pediatric dermatology ,business ,medicine.drug - Published
- 2018
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35. Cutaneous Ulceration in Dermatomyositis: Association With Anti-Melanoma Differentiation-Associated Gene 5 Antibodies and Interstitial Lung Disease
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Livia Casciola-Rosen, Shufeng Li, David Fiorentino, Lorinda Chung, and Neera S. Narang
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Pathology ,medicine.medical_specialty ,Cutaneous ulceration ,genetic structures ,biology ,business.industry ,Interstitial lung disease ,Odds ratio ,Dermatomyositis ,medicine.disease ,digestive system diseases ,Serology ,MELANOMA DIFFERENTIATION-ASSOCIATED GENE 5 ,Cutaneous ulcers ,Rheumatology ,biology.protein ,Medicine ,Antibody ,business - Abstract
Objective To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM).
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- 2015
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36. Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection
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Gökçen ÖZ TUNÇER, Pelin ALBAYRAK, Muhammed Gültekin KUTLUK, Özben AKINCI GÖKTAŞ, and Serap TEBER
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General and Internal Medicine ,medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Multiple sclerosis ,Interferon beta-1a ,medicine.disease ,Interferon beta 1a ,Fingolimod ,Dermatology ,medicine.anatomical_structure ,medicine ,Abdomen ,In patient ,medicine.symptom ,business ,Genel ve Dahili Tıp ,Postinflammatory hyperpigmentation ,Interferon beta-1a Injection ,medicine.drug - Abstract
Subcutaneous interferon beta 1a (IFN β 1a) has been shown to reduce relapse rates in patients with relapsing-remitting multiple sclerosis. We report the occurrence of severe necrotizing cutaneous reactions in a 19-year-old girl. She self injected IFN β 1a three times a week on the abdomen and both thighs. Treatment was initially well tolerated, but she described erythematous patches and local pain at the injection sites recently. The areas on the abdomen became violaceous with necrotic ulcers. Her therapy was changed to 0.5 mg fingolimod. The lesions began to improve and cicatrize after several weeks with postinflammatory hyperpigmentation. Early recognition of severe local adverse reactions and correction of the injection technique is important. more...
- Published
- 2018
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37. Vasodilation is not the only approach to the management of cutaneous ulceration in systemic sclerosis
- Author
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John D Pauling
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Cutaneous ulceration ,Treatment outcome ,Vasodilation ,Minocycline ,Scleroderma ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Hyperpigmentation ,Skin Ulcer ,Medicine ,Humans ,Pharmacology (medical) ,030203 arthritis & rheumatology ,business.industry ,Skin ulcer ,Middle Aged ,medicine.disease ,Dermatology ,Anti-Bacterial Agents ,030104 developmental biology ,Treatment Outcome ,Scleroderma, Diffuse ,Female ,medicine.symptom ,business ,medicine.drug - Published
- 2017
38. Cutaneous ulceration and breast implant compromise after pulse dye laser for radiation-induced telangiectasias
- Author
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Kishwer S. Nehal, Babak J. Mehrara, Anthony M. Rossi, and Erica H. Lee
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medicine.medical_specialty ,Dye laser ,Cutaneous ulceration ,business.industry ,Radiation induced ,Case Report ,Dermatology ,lcsh:RL1-803 ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,law ,030220 oncology & carcinogenesis ,Breast implant ,lcsh:Dermatology ,Medicine ,business - Published
- 2017
39. Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers
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Gregory J. Kato, Caterina P. Minniti, Matthew M. Hsieh, Joseph L. Connor, and Joseph A. Sclafani
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Adult ,Male ,medicine.medical_specialty ,Cutaneous ulceration ,Adolescent ,Administration, Topical ,wound ,Avascular necrosis ,Anemia, Sickle Cell ,Disease ,sickle cell ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Quality of life ,Internal medicine ,Quality Improvement Study ,leg ulcer ,medicine ,Humans ,In patient ,Patient Reported Outcome Measures ,Prospective Studies ,Sodium nitrite ,Wound Healing ,sodium nitrite ,business.industry ,Hematopoietic Stem Cell Transplantation ,General Medicine ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Treatment Outcome ,Leg ulcer ,quality of life ,chemistry ,030220 oncology & carcinogenesis ,Preoperative Period ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,business ,Research Article - Abstract
Supplemental Digital Content is available in the text, Cutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers. We prospectively collected data in patients enrolled in a leg ulcer study (n = 17) or an allogeneic hematopoietic cell transplant study (nonulcer group, n = 15). Both groups completed a pretreatment Short Form-36 questionnaire; the ulcer group completed a second questionnaire after 4 weeks of topical sodium nitrite applications. Data were analyzed by age, sex, >50% area improvement postintervention, and sickle-related complications (vaso-occlusive crises, pulmonary hypertension, or avascular necrosis). Physical and mental component summary scores were analyzed with Student t test. Physical summary scores were lower than mental summary scores in all groups, indicating leg ulcers among other sickle related complications negatively impacted physical quality of life measures. After sodium nitrite use, physical summary scores improved in the leg ulcer group (34.5 ± 9.4 to 39 ± 10.3, P = .03), and mental summary scores improved more in ulcerated patients ≤35 years old (40.7 ± 6.9 to 51.7 ± 9.7, P = .01). Brief topical sodium nitrite has the potential to improve quality of life, especially in younger individuals. Longer treatment duration and randomized-controlled trials are needed to confirm the efficacy of this topical therapy. more...
- Published
- 2018
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40. KUTANÖZ ÜLSERLER İLE SEYREDEN AKUT METOTREKSAT TOKSİSİTESİ / ACUTE METHOTREXATE TOXICITY PRESENTING WITH CUTANEOUS ULCERATIONS
- Author
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Abdurrahman Aslan, Isil Bulur, Zeynep Nurhan Saraçoğlu, Bahadir Yildiz, and Hilal Kaya Erdoğan
- Subjects
medicine.medical_specialty ,Cutaneous ulceration ,Methotrexate Toxicity ,business.industry ,medicine.disease ,kutanöz ülser,metotreksat ,Dermatology ,Acute stage ,Health Care Sciences and Services ,Psoriasis ,Toxicity ,medicine ,Methotrexate ,Chronic dermatosis ,Sağlık Bilimleri ve Hizmetleri ,business ,Skin Findings ,medicine.drug - Abstract
OZET: Psoriazis eritemli, skuamli ve endure plaklarla karakterize, en sik sacli deri ve ekstansor yuzeyleri tutan kronik bir dermatozdur. Metotreksat psoriazis tedavisinde yaygin kullanilan sentetik bir folik asit analogudur. Kanda nadiren toksik duzeylere ulasarak siddetli yan etkilere sebep olur. Bu durumda akut donemde psoriatik plaklarda ulserasyon ve nekrozla karakterize cilt bulgulari ortaya cikar. Cogu olguda sebep, ilacin yanlislikla haftalik rejim yerine daha kisa surelerde veya bir defada cok miktarda alinmasidir. Eslik eden ileri yas ve renal yetmezlik gibi nedenler de toksisiteye katkida bulunur. Metotreksat toksisitesini erken donemde tanimak ve hemen tedaviye baslamak acisindan kutanoz bulgular oldukca onemlidir. Burada klinigimize basvuran bir olgudan hareketle akut metotreksat toksisitesine yaklasim ele alinacaktir.. ANAHTAR KELIMELER: kutanoz ulser, metotreksat, psoriazis ACUTE METHOTREXATE TOXICITY PRESENTING WITH CUTANEOUS ULCERATIONS ABSTRACT: Psoriasis is a chronic dermatosis characterized by erythematosus, scaly and indurated plaques which are most often located on scalp and extensor surfaces. Methotrexate is a synthetic folic asid analogue which is commonly used for the treatment of psoriasis. It rarely reaches toxic levels in the blood and causes severe adverse effects. In this situation, skin findings characterized by ulcerations and necrosis on psoriatic plaques emerge at the acute stage. In the most of the cases, the reason is misuse of the drug which is taking medicine at short intervals or too much during a treatment session instead of weekly regimen. Additional causes such as renal failure and older age contribute toxicity. Cutaneous findings are quite important to recognize methotrexate toxicity at the early stages and to start the treatment immediately. Herein, the approach to acute methotrexate toxicity will be discussed with reference to a case who is referred to our clinic. KEYWORDS: cutaneous ulceration, methotrexate, psoriasis more...
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- 2016
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41. Case of sarcoidosis with seasonal cutaneous ulceration
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Hikari Fujii and Hideshi Torii
- Subjects
medicine.medical_specialty ,Cutaneous ulceration ,business.industry ,Dermatology ,General Medicine ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030212 general & internal medicine ,Sarcoidosis ,business - Published
- 2016
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42. Zonal cutaneous ulceration and necrosis of the lower abdomen due to cutaneous thrombosis associated with paroxysmal nocturnal hemoglobinuria
- Author
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Yukari Shirasugi, Tami Ota, Tomotaka Mabuchi, Mayu Kawai, Kiyoshi Ando, Yuta Kurashige, Takahiko Yamada, Norihiro Ikoma, and Michio Tokuyama
- Subjects
medicine.medical_specialty ,Necrosis ,Cutaneous ulceration ,medicine.diagnostic_test ,business.industry ,Dermatology ,General Medicine ,030204 cardiovascular system & hematology ,Skin ulcer ,medicine.disease ,Thrombosis ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Biopsy ,Paroxysmal nocturnal hemoglobinuria ,Medicine ,Abdomen ,medicine.symptom ,business - Published
- 2016
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43. Clinical and histological comparison of ulcerated lichen planus and chronic cutaneous lupus erythematosus: Aseries of six cases
- Author
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Kapil Chandra, Krishnakumar Subramanian, Asha Kubba, Meenakshi Batrani, and Raj Kubba
- Subjects
Cutaneous ulcer ,Pathology ,medicine.medical_specialty ,Cutaneous ulceration ,Lupus erythematosus ,lichen planus ,Anti-nuclear antibody ,business.industry ,General Medicine ,lcsh:RL1-803 ,erosion ,medicine.disease ,Dermatology ,Cutaneous ulcers ,Clinical diagnosis ,lcsh:Dermatology ,medicine ,Cutaneous Lupus Erythematosus ,skin and connective tissue diseases ,business ,Direct fluorescent antibody ,lupus erythematosus - Abstract
Cutaneous ulceration as the primary manifestation of chronic cutaneous lupus erythematosus (CCLE) and lichen planus (LP) is uncommon. In the absence of typical lesions, clinical diagnosis is challenging. We report six cases, three each of, CCLE and LP that presented with cutaneous ulcers. A detailed comparison of clinical and histopathological features between two groups was conducted. The statistical significance of comparative features could not be assessed because of small number of cases. In view of clinical and histopathological overlap, diagnosis requires clinico-pathological correlation and ancillary tests including direct immunofluorescence and antinuclear antibodies. more...
- Published
- 2016
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44. Methotrexate-induced nonhealing cutaneous ulcers in a nonpsoriatic patient without pancytopenia
- Author
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Venkatesh Krishnamurthy Tekur
- Subjects
Cutaneous ulcer ,Microbiology (medical) ,medicine.medical_specialty ,Cutaneous ulceration ,Case Report ,02 engineering and technology ,Dermatology ,methotrexate ,pancytopenia ,Lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,lcsh:Dermatology ,medicine ,Immunology and Allergy ,In patient ,business.industry ,psoriasis ,lcsh:RL1-803 ,021001 nanoscience & nanotechnology ,medicine.disease ,Pancytopenia ,Infectious Diseases ,Cutaneous ulcers ,Rheumatoid arthritis ,Methotrexate ,medicine.symptom ,0210 nano-technology ,business ,medicine.drug - Abstract
Methotrexate forms one of the main drugs in the pharmacological management of rheumatoid arthritis, psoriasis, and some neoplastic diseases. Methotrexate rarely causes cutaneous ulceration and most cases are reported in patients with psoriasis and have been accompanied by pancytopenia. The author here reports occurrence of multiple (two) cutaneous ulcers due to methotrexate in a nonpsoriatic patient. The patient was on methotrexate for seronegative rheumatoid arthritis for 10 years. To the best of the Author's knowledge, this is a rare case of cutaneous ulceration due to methotrexate in a nonpsoriatic patient reported in the literature so far, and probably one of its kind without pancytopenia or other hematological abnormalities. Stopping this medication led to complete healing of the ulcerated lesion in about four to six weeks. more...
- Published
- 2016
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45. Complications from microfocused transcutaneous ultrasound: Case series and review of the literature.
- Author
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Friedmann DP, Bourgeois GP, Chan HHL, Zedlitz AC, and Butterwick KJ
- Subjects
- Adult, Cosmetic Techniques instrumentation, Face, Female, High-Intensity Focused Ultrasound Ablation instrumentation, Humans, Male, Middle Aged, Retrospective Studies, Cosmetic Techniques adverse effects, High-Intensity Focused Ultrasound Ablation adverse effects, Skin Aging
- Abstract
Background and Objective: Microfocused ultrasound (MFUS) technology has been utilized since 2009 for improvement in mild to moderate skin and soft tissue laxity of the face and neck. Few complications have been previously reported, the majority of which include mild and transient erythema, edema, ecchymosis, and nerve paralysis. Rare yet serious potential complications of MFUS for noninvasive skin tightening of the face and neck are, however, possible., Methods & Materials: Retrospective multicenter case series of five patients from the authors' practice who developed serious adverse events directly related to MFUS with a commercially available device (Ultherapy; Merz North America, Inc., Raleigh, NC)., Results: Five patients developed blistering, erosion/ulceration, cutaneous, or subcutaneous tissue edema with resulting atrophy, and/or cutaneous necrosis following single sessions of MFUS., Conclusion: Despite their rarity, serious adverse events secondary to MFUS are nevertheless possible and may be underreported. Early management of complications includes local wound care, patient reassurance, and topical corticosteroids and/or pulsed-dye laser to mitigate inflammatory sequelae. Other cosmetic and surgical therapies should be utilized when conservative measures have failed. Lasers Surg. Med. 50:13-19, 2018. © 2017 Wiley Periodicals, Inc., (© 2017 Wiley Periodicals, Inc.) more...
- Published
- 2018
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46. Low-dose methotrexate-induced ulcerated psoriatic plaques: A rare case.
- Author
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Hsu MC and Chen CC
- Published
- 2015
- Full Text
- View/download PDF
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