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Your search keyword '"Croker, Daniel"' showing total 12 results
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12 results on '"Croker, Daniel"'

2. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Author

Coll, Rebecca C., Robertson, Avril A.B., Chae, Jae Jin, Higgins, Sarah C., Munoz-Planillo, Raul, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stutz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Nunez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H.G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., and O'Neill, Luke A.J.

Subjects
Inflammatory bowel diseases -- Risk factors -- Genetic aspects -- Care and treatment -- Research, Apoptosis -- Research, Biological sciences, Health
Abstract

The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is a component of the inflammatory process, and its aberrant activation is pathogenic in inherited disorders such as cryopyrin-associated periodic syndrome (CAPS) and complex diseases such as multiple sclerosis, type 2 diabetes, Alzheimer's disease and atherosclerosis. We describe the development of MCC950, a potent, selective, small-molecule inhibitor of NLRP3. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Furthermore, MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle-Wells syndrome. MCC950 is thus a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease., The NLR family protein NLRP3 is an intracellular signaling molecule that senses many pathogen-derived, environmental and host-derived factors (1). Upon activation, NLRP3 binds to apoptosis-associated speck-like protein containing a CARD [...]

Published
2015
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6. Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

Author

Salla, Manohar, primary, Butler, Mark S., additional, Pelingon, Ruby, additional, Kaeslin, Geraldine, additional, Croker, Daniel E., additional, Reid, Janet C., additional, Baek, Jong Min, additional, Bernhardt, Paul V., additional, Gillam, Elizabeth M. J., additional, Cooper, Matthew A., additional, and Robertson, Avril A. B., additional

Published
2016
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7. Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

Author

Croker, Daniel E, primary, Monk, Peter N, additional, Halai, Reena, additional, Kaeslin, Geraldine, additional, Schofield, Zoe, additional, Wu, Mike CL, additional, Clark, Richard J, additional, Blaskovich, Mark AT, additional, Morikis, Dimitrios, additional, Floudas, Christodoulos A, additional, Cooper, Matthew A, additional, and Woodruff, Trent M, additional

Published
2016
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8. Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties

Author

Brust, Andreas, primary, Croker, Daniel E., additional, Colless, Barbara, additional, Ragnarsson, Lotten, additional, Andersson, Åsa, additional, Jain, Kapil, additional, Garcia-Caraballo, Sonia, additional, Castro, Joel, additional, Brierley, Stuart M, additional, Alewood, Paul F., additional, and Lewis, Richard J., additional

Published
2016
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9. 30

Author

Coll, Rebecca C., primary, Robertson, Avril A.B., additional, Chae, Jae Jin, additional, Higgins, Sarah C., additional, Dungan, Lara S., additional, Muñoz-Planillo, Raul, additional, Monks, Brian G., additional, Croker, Daniel E., additional, Sutton, Caroline E., additional, Stutz, Andrea, additional, Nunez, Gabriel, additional, Latz, Eicke, additional, Kastner, Daniel L., additional, Mills, Kingston H.G., additional, Masters, Seth L., additional, Schroder, Kate, additional, Cooper, Matt A., additional, and O’Neill, Luke A.J., additional

Published
2014
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10. 32

Author

Croker, Daniel E., primary, Halai, Reena, additional, Kaeslin, Geraldine, additional, Morikis, Dimitrios, additional, Woodruff, Trent, additional, Floudas, Christodoulos A., additional, Monk, Peter N., additional, and Cooper, Matthew A., additional

Published
2014
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12. 30: MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases

Author

Coll, Rebecca C., Robertson, Avril A.B., Chae, Jae Jin, Higgins, Sarah C., Dungan, Lara S., Muñoz-Planillo, Raul, Monks, Brian G., Croker, Daniel E., Sutton, Caroline E., Stutz, Andrea, Nunez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H.G., Masters, Seth L., Schroder, Kate, Cooper, Matt A., and O’Neill, Luke A.J.

Published
2014
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