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309 results on '"Cools, Filip"'

2. Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia

Author

van der Veer, Marlotte A. A., de Haan, Timo R., Franken, Linda G. W., Groenendaal, Floris, Dijk, Peter H., de Boode, Willem P., Simons, Sinno, Dijkman, Koen P., van Straaten, Henrica L.M., Rijken, Monique, Cools, Filip, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Bijleveld, Yuma. A., Mathôt, Ron A. A., Brouwer, Mieke J., van den Broek, Marcel P., Rademaker, Carin M. A., Liem, Djien, Steiner, Katerina, Bos, Annelies A., Tollenaer, S. M. Mulder-de, Jebbink-Akkerman, L. J. M. Groot, Sonnaert, Michel, and Camfferman, Fleur Anne

Published
2024
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8. Effect of Systemic Hydrocortisone on Brain Abnormalities and Regional Brain Volumes in Ventilator-dependent Infants Born Preterm: Substudy of the SToP-BPD Study

Author

MS Neonatologie, Brain, Child Health, Developmental Disorders, Circulatory Health, Halbmeijer, Nienke M., Onland, Wes, Dudink, Jeroen, Cools, Filip, Debeer, Anne, van Kaam, Anton H., Benders, Manon J.N.L., van der Aa, Niek E., MS Neonatologie, Brain, Child Health, Developmental Disorders, Circulatory Health, Halbmeijer, Nienke M., Onland, Wes, Dudink, Jeroen, Cools, Filip, Debeer, Anne, van Kaam, Anton H., Benders, Manon J.N.L., and van der Aa, Niek E.

Published
2024

9. Brill-Noether theory of curves on $\mathbb{P}^1 \times \mathbb{P}^1$: tropical and classical approach

Author

Cools, Filip, D'Adderio, Michele, Jensen, David, and Panizzut, Marta

Subjects
Mathematics - Algebraic Geometry
Abstract

The gonality sequence $(d_r)_{r\geq1}$ of a smooth algebraic curve comprises the minimal degrees $d_r$ of linear systems of rank $r$. We explain two approaches to compute the gonality sequence of smooth curves in $\mathbb{P}^1 \times \mathbb{P}^1$: a tropical and a classical approach. The tropical approach uses the recently developed Brill--Noether theory on tropical curves and Baker's specialization of linear systems from curves to metric graphs. The classical one extends the work of Hartshorne on plane curves to curves on $\mathbb{P}^1 \times \mathbb{P}^1$.

Published
2017

10. Minimal polygons with fixed lattice width

Author

Cools, Filip and Lemmens, Alexander

Subjects
Mathematics - Combinatorics
Abstract

We classify the unimodular equivalence classes of inclusion-minimal polygons with a certain fixed lattice width. As a corollary, we find a sharp upper bound on the number of lattice points of these minimal polygons., Comment: 8 pages, 3 figures

Published
2017

11. Association between seizures and neurodevelopmental outcome at two- and five years in asphyxiated newborns with therapeutic hypothermia

Author

Langeslag, J.F., primary, Onland, W., additional, Groenendaal, F., additional, de Vries, L.S., additional, van Kaam, A.H., additional, de Haan, T.R., additional, van den Akker, Chris H.P., additional, de Boode, Willem P., additional, Cools, Filip, additional, ter Horst, Henk J., additional, Dijkman, Koen P., additional, Groenendaal, Floris, additional, de Haan, Timo R., additional, Simons, Sinno H.P., additional, Steggerda, Sylke J., additional, Mulder-Tollenaer, Suzanne, additional, and Zecic, Alexandra, additional

Published
2024
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13. Canonical syzygies of smooth curves on toric surfaces

Author

Castryck, Wouter, Cools, Filip, Demeyer, Jeroen, and Lemmens, Alexander

Subjects
Mathematics - Algebraic Geometry, Mathematics - Combinatorics
Abstract

In a first part of this paper, we prove constancy of the canonical graded Betti table among the smooth curves in linear systems on Gorenstein weak Fano toric surfaces. In a second part, we show that Green's canonical syzygy conjecture holds for all smooth curves of genus at most 32 or Clifford index at most 6 on arbitrary toric surfaces. Conversely we use known results on Green's conjecture (due to Lelli-Chiesa) to obtain new facts about graded Betti tables of projectively embedded toric surfaces.

Published
2016

14. Computing graded Betti tables of toric surfaces

Author

Castryck, Wouter, Cools, Filip, Demeyer, Jeroen, and Lemmens, Alexander

Subjects
Mathematics - Algebraic Geometry, Mathematics - Combinatorics
Abstract

We present various facts on the graded Betti table of a projectively embedded toric surface, expressed in terms of the combinatorics of its defining lattice polygon. These facts include explicit formulas for a number of entries, as well as a lower bound on the length of the linear strand that we conjecture to be sharp (and prove to be so in several special cases). We also present an algorithm for determining the graded Betti table of a given toric surface by explicitly computing its Koszul cohomology, and report on an implementation in SageMath. This works well for ambient projective spaces of dimension up to roughly $25$, depending on the concrete combinatorics, although the current implementation runs in finite characteristic only. As a main application we obtain the graded Betti table of the Veronese surface $\nu_6(\mathbb{P}^2) \subseteq \mathbb{P}^{27}$ in characteristic $40\,009$. This allows us to formulate precise conjectures predicting what certain entries look like in the case of an arbitrary Veronese surface $\nu_d(\mathbb{P}^2)$.

Published
2016

15. The gonality sequence of complete graphs

Author

Cools, Filip and Panizzut, Marta

Subjects
Mathematics - Combinatorics, Mathematics - Algebraic Geometry
Abstract

The gonality sequence $(\gamma_r)_{r\geq1}$ of a finite graph / metric graph / algebraic curve comprises the minimal degrees $\gamma_r$ of linear systems of rank $r$. For the complete graph $K_d$, we show that $\gamma_r = kd - h$ if $r

Published
2016

16. On metric graphs with prescribed gonality

Author

Cools, Filip and Draisma, Jan

Subjects
Mathematics - Combinatorics, Mathematics - Algebraic Geometry, 05C99, 14T05, 14H51
Abstract

We prove that in the moduli space of genus-g metric graphs the locus of graphs with gonality at most d has the classical dimension min{3g-3,2g+2d-5}. This follows from a careful parameter count to establish the upper bound and a construction of sufficiently many graphs with gonality at most d to establish the lower bound. Here, gonality is the minimal degree of a non-degenerate harmonic map to a tree that satisfies the Riemann-Hurwitz condition everywhere. Along the way, we establish a convenient combinatorial datum capturing such harmonic maps to trees., Comment: 18 pages, 10 figures, corrected an erroneous lemma in previous version, many further improvements suggested by referees

Published
2016

17. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

Author

Vento, Giovanni, Ventura, Maria Luisa, Pastorino, Roberta, van Kaam, Anton H, Carnielli, Virgilio, Cools, Filip, Dani, Carlo, Mosca, Fabio, Polglase, Graeme, Tagliabue, Paolo, Boni, Luca, Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Costa, Simonetta, D'Andrea, Vito, Lucente, Mariella, Nigro, Gabriella, Giordano, Lucio, Roma, Vincenzina, Villani, Paolo E, Fusco, Francesca P, Fasolato, Valeria, Colnaghi, Maria Rosa, Matassa, Piero G, Vendettuoli, Valentina, Poggi, Chiara, Del Vecchio, Antonio, Petrillo, Flavia, Betta, Pasqua, Mattia, Carmine, Garani, Giampaolo, Solinas, Agostina, Gitto, Eloisa, Salvo, Vincenzo, Gargano, Giancarlo, Balestri, Eleonora, Sandri, Fabrizio, Mescoli, Giovanna, Martinelli, Stefano, Ilardi, Laura, Ciarmoli, Elena, Di Fabio, Sandra, Maranella, Eugenia, Grassia, Carolina, Ausanio, Gaetano, Rossi, Vincenzo, Motta, Angela, Tina, Lucia G, Maiolo, Kim, Nobile, Stefano, Messner, Hubert, Staffler, Alex, Ferrero, Federica, Stasi, Ilaria, Pieragostini, Luisa, Mondello, Isabella, Haass, Cristina, Consigli, Chiara, Vedovato, Stefania, Grison, Alessandra, Maffei, Gianfranco, Presta, Giuseppe, Perniola, Roberto, Vitaliti, Marcello, Re, Maria P, De Curtis, Mario, Cardilli, Viviana, Lago, Paola, Tormena, Francesca, Orfeo, Luigi, Gizzi, Camilla, Massenzi, Luca, Gazzolo, Diego, Strozzi, Maria Chiara M, Bottino, Roberto, Pontiggia, Federica, Berardi, Alberto, Guidotti, Isotta, Cacace, Caterina, Meli, Valerio, Quartulli, Lorenzo, Scorrano, Antonio, Casati, Alessandra, Grappone, Lidia, and Pillow, J Jane

Published
2021
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18. A combinatorial interpretation for Schreyer's tetragonal invariants

Author

Castryck, Wouter and Cools, Filip

Subjects
Mathematics - Algebraic Geometry, Mathematics - Combinatorics, Primary 14H45, Secondary 14M25
Abstract

Schreyer has proved that the graded Betti numbers of a canonical tetragonal curve are determined by two integers $b_1$ and $b_2$, associated to the curve through a certain geometric construction. In this article we prove that in the case of a smooth projective tetragonal curve on a toric surface, these integers have easy interpretations in terms of the Newton polygon of its defining Laurent polynomial. We can use this to prove an intrinsicness result on Newton polygons of small lattice width., Comment: 16 pages, 5 figures

Published
2014

19. A minimal set of generators for the canonical ideal of a non-degenerate curve

Author

Castryck, Wouter and Cools, Filip

Subjects
Mathematics - Algebraic Geometry, Mathematics - Combinatorics, Primary 14H45, Secondary 14M25
Abstract

We give an explicit way of writing down a minimal set of generators for the canonical ideal of a non-degenerate curve, or of a more general smooth projective curve in a toric surface, in terms of its defining Laurent polynomial., Comment: 14 pages, 6 figures, accepted for publication in Journal of the Australian Mathematical Society

Published
2014

21. Cause of death and making end-of-life decisions in preterm infants has not changed over time: A mortality follow-back survey.

Author

Goossens, Linde, Dombrecht, Laure, Chambaere, Kenneth, Beernaert, Kim, and Cools, Filip

Subjects
PREMATURE infants, CAUSES of death, DECISION making, MORTALITY, ATTITUDE change (Psychology)
Abstract

Aim: This study aimed to evaluate changes over time in cause of death and making end-of-life decisions in preterm infants. Methods: A follow-back survey was conducted of all preterm infants who died between September 2016 and December 2017 in Flanders and Brussels, Belgium. Cause of death was obtained from the death certificate and information on end-of-life decisions (ELDs) through an anonymous questionnaire of the certifying physician. Results were compared with a previous study performed between August 1999 and July 2000. Results: In the cohort 1999-2000 and 2016-2017, respectively, 150 and 135 deaths were included. A significantly higher proportion of infants born before 26 weeks of gestation was found in the 2016-2017 cohort (53% vs. 24% in 1999-2000, p < 0.001). Extreme immaturity (<26 weeks) remained the most prevalent cause with a significant increase in the 2016-2017 cohort (48% vs. 28% in 1999-2000, p < 0.001). The overall prevalence of ELDs was similar across study periods (61%). Non-treatment decisions remained the most common ELD (36% and 37%). Conclusion: Infants born at the limits of viability have become more prevalent among infant deaths, possibly due to a change in attitude towards periviable births. Neither the process of making ELDs nor the cause of death has changed over time. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia.

Author

van der Veer, Marlotte A. A., de Haan, Timo R., Franken, Linda G. W., van Hest, Reinier M., Groenendaal, Floris, Dijk, Peter H., de Boode, Willem P., Simons, Sinno, Dijkman, Koen P., van Straaten, Henrica L. M., Rijken, Monique, Cools, Filip, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Bijleveld, Yuma A., and Mathôt, Ron A. A.

Subjects
THERAPEUTIC hypothermia, ASPHYXIA neonatorum, NEWBORN infants, VANCOMYCIN, PHARMACOKINETICS, BIRTH weight
Abstract

Aims: Little is known about the population pharmacokinetics (PPK) of vancomycin in neonates with perinatal asphyxia treated with therapeutic hypothermia (TH). We aimed to describe the PPK of vancomycin and propose an initial dosing regimen for the first 48 h of treatment with pharmacokinetic/pharmacodynamic target attainment. Methods: Neonates with perinatal asphyxia treated with TH were included from birth until Day 6 in a multicentre prospective cohort study. A vancomycin PPK model was constructed using nonlinear mixed‐effects modelling. The model was used to evaluate published dosing guidelines with regard to pharmacokinetic/pharmacodynamic target attainment. The area under the curve/minimal inhibitory concentration ratio of 400–600 mg*h/L was used as target range. Results: Sixteen patients received vancomycin (median gestational age: 41 [range: 38–42] weeks, postnatal age: 4.4 [2.5–5.5] days, birth weight: 3.5 [2.3–4.7] kg), and 112 vancomycin plasma concentrations were available. Most samples (79%) were collected during the rewarming and normothermic phase, as vancomycin was rarely initiated during the hypothermic phase due to its nonempirical use. An allometrically scaled 1‐compartment model showed the best fit. Vancomycin clearance was 0.17 L/h, lower than literature values for term neonates of 3.5 kg without perinatal asphyxia (range: 0.20–0.32 L/h). Volume of distribution was similar. Published dosing regimens led to overexposure within 24 h of treatment. A loading dose of 10 mg/kg followed by 24 mg/kg/day in 4 doses resulted in target attainment. Conclusion: Results of this study suggest that vancomycin clearance is reduced in term neonates with perinatal asphyxia treated with TH. Lower dosing regimens should be considered followed by model‐informed precision dosing. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The Use of Standardized Solutions Instead of Individualized Prescriptions for Parenteral Nutrition on the Neonatal Intensive Care Unit in UZ Brussel: A Feasibility Study.

Author

Batteux, Melanie, Meers, Garmt, Fien, Bockstal, Cortoos, Pieter-Jan, and Cools, Filip

Subjects
MEDICAL protocols, PARENTERAL feeding, PARENTERAL solutions, FOOD consumption, CRITICALLY ill, PATIENTS, NEONATAL intensive care units, PILOT projects, NEONATAL intensive care, RETROSPECTIVE studies, NUTRITIONAL requirements, PHYSICIAN practice patterns, MEDICAL records, ACQUISITION of data, GESTATIONAL age, DRUGS, INDIVIDUALIZED medicine
Abstract

For parenteral nutrition (PN) of newborns, the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) 2018 guidelines recommend standardized solutions over individual PN (IPN) solutions for most patients. This retrospective study assessed if a shift from IPN to standardized PN was feasible at the UZ Brussel. Using prescription data of 145 neonates, we calculated the nutrient provision for IPN and for standardized PN of the same volumes. We compared the macronutrient intakes with ESPGHAN 2018 recommendations to assess the feasibility. For neonates of a gestational age (GA) <32 or >36 weeks, standardized PN reached recommendations as least as fast as IPN. For neonates with a GA of 32 to 36 weeks, the administration protocol requires further adjustments as amino acid provision was lacking compared to IPN. Overall, the results support the feasibility of a shift from IPN to standardized PN at the UZ Brussel. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The use of a T-piece resuscitator in the newborn infants

Author

Van Delft, Brenda, Fauconnier, Gwenn, Cools, Filip, Lefevere, Julie Sara, Van Delft, Christel, Clinical sciences, Faculty of Medicine and Pharmacy, Growth and Development, Neonatology, and UZB Other

Published
2023

31. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years' corrected age

Author

SToP-BPD Study Group, Halbmeijer, Nienke Marjolein, Onland, Wes, Cools, Filip, Swarte, Renate M, van der Heide-Jalving, Marja, Dijk, Peter, Mulder-de Tollenaer, Susanne, Tan, Ratna N G B, Mohns, Thilo, Bruneel, Els, van Heijst, Arno F J, Kramer, Boris, Debeer, Anne, van Weissenbruch, Mirjam M, Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Offringa, Martin, van Wassenaer-Leemhuis, Aleid G, van Kaam, Anton H, Aarnoudse-Moens, Cornelieke S H, Neonatology, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, STOP-BPD Study Group, RS: MHeNs - R3 - Neuroscience, RS: GROW - R4 - Reproductive and Perinatal Medicine, and MUMC+: MA Medische Staf Kindergeneeskunde (9)

Subjects
BIRTH, MORTALITY, SCHOOL-AGE, MULTICENTER, Obstetrics and Gynecology, General Medicine, BRONCHOPULMONARY DYSPLASIA, THERAPY, neonatology, DEXAMETHASONE, Pediatrics, Perinatology and Child Health, SURVIVAL, Human medicine, Pediatrics, Perinatology, and Child Health, CHILDREN BORN, Child development, INITIATED 7
Abstract

ObjectiveTo report the parent-reported behavioural outcomes of infants included in the Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants study at 2 years’ corrected age (CA).DesignRandomised placebo-controlled trial.SettingDutch and Belgian neonatal intensive care units.PatientsInfants born InterventionInfants were randomly assigned to a 22-day course of systemic hydrocortisone (cumulative dose 72.5 mg/kg; n=182) or placebo (n=190).Main outcome measuresParent-reported behavioural outcomes at 2 years’ CA assessed with the Child Behavior Checklist (CBCL 1½−5).ResultsParents completed the CBCL of 183 (70% (183/262)) infants (hydrocortisone group, n=96; placebo group, n=87). Multiple imputation was used to account for missing data. Infants with critically elevated T-scores (>55) were found in 22.9%, 19.1% and 29.4% of infants for total, internalising and externalising problems, respectively; these scores were not significantly different between groups (mean difference −1.52 (95% CI −4.00 to 0.96), −2.40 (95% CI −4.99 to 0.20) and −0.81 (95% CI −3.40 to 1.77), respectively). In the subscales, we found a significantly lower T-score for anxiety problems in the hydrocortisone group (mean difference −1.26, 95% CI −2.41 to –0.12).ConclusionThis study found high rates of behaviour problems at 2 years’ CA following very preterm birth, but these problems were not associated with hydrocortisone treatment initiated between 7 and 14 days after birth in ventilated preterm infants.Trial registration numberNTR2768; EudraCT 2010-023777-19.

Published
2023

32. Survey of transfusion practices in preterm infants in Europe

Author

Neonatal Transfusion Network, Scrivens, Alexandra, Reibel, Nora Johanna, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Braekke, Kristin, Cardona, Francesco Stefano, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph, Fustolo-Gunnink, Suzanne, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, Neonatology, Paediatric Haematology, AII - Infectious diseases, and ARD - Amsterdam Reproduction and Development

Subjects
data collection, Epidemiology, Pediatrics, Perinatology and Child Health, Child Health, Obstetrics and Gynecology, General Medicine, Pediatrics, Perinatology, and Child Health, Healthcare Disparities, neonatology
Abstract

BackgroundPreterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data.MethodsFrom October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of ResultsResponses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×109/L in non-bleeding infants of GA of 9/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs.ConclusionsTransfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.

Published
2023

34. Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia

Author

van der Veer, Marlotte A. A., primary, de Haan, Timo R., additional, Franken, Linda G. W., additional, Hodiamont, Caspar J., additional, Groenendaal, Floris, additional, Dijk, Peter H., additional, de Boode, Willem P., additional, Simons, Sinno, additional, Dijkman, Koen P., additional, van Straaten, Henrica L. M., additional, Rijken, Monique, additional, Cools, Filip, additional, Nuytemans, Debbie H. G. M., additional, van Kaam, Anton H., additional, Bijleveld, Yuma A., additional, Mathôt, Ron A. A., additional, Brouwer, Mieke J., additional, van den Broek, Marcel P., additional, Rademaker, Carin M. A., additional, Liem, Djien, additional, Steiner, Katerina, additional, Simons, Sinno H. P., additional, Bos, Annelies A., additional, Mulder-de Tollenaer, S. M., additional, Jebbink-Akkerman, L. J. M. Groot, additional, Sonnaert, Michel, additional, and Camfferman, Fleur Anne, additional

Published
2023
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35. Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia

Author

MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, van der Veer, Marlotte A A, de Haan, Timo R, Franken, Linda G W, Hodiamont, Caspar J, Groenendaal, Floris, Dijk, Peter H, de Boode, Willem P, Simons, Sinno, Dijkman, Koen P, van Straaten, Henrica L M, Rijken, Monique, Cools, Filip, Nuytemans, Debbie H G M, van Kaam, Anton H, Bijleveld, Yuma A, Mathôt, Ron A A, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, van der Veer, Marlotte A A, de Haan, Timo R, Franken, Linda G W, Hodiamont, Caspar J, Groenendaal, Floris, Dijk, Peter H, de Boode, Willem P, Simons, Sinno, Dijkman, Koen P, van Straaten, Henrica L M, Rijken, Monique, Cools, Filip, Nuytemans, Debbie H G M, van Kaam, Anton H, Bijleveld, Yuma A, and Mathôt, Ron A A

Published
2023

36. Survey of transfusion practices in preterm infants in Europe

Author

Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, Neonatal Transfusion Network, Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, and Neonatal Transfusion Network

Abstract

BACKGROUND Preterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data. METHODS From October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of <32 weeks in 18 European countries. RESULTS Responses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×10$^{9}$/L in non-bleeding infants of GA of <28 weeks, while the 25×10$^{9}$/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs. CONCLUSIONS Transfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.

Published
2023

39. Survey of transfusion practices in preterm infants in Europe

Author

Scrivens, Alexandra, primary, Reibel, Nora Johanna, additional, Heeger, Lisanne, additional, Stanworth, Simon, additional, Lopriore, Enrico, additional, New, Helen V, additional, Dame, Christof, additional, Fijnvandraat, Karin, additional, Deschmann, Emöke, additional, Aguar, Marta, additional, Brække, Kristin, additional, Cardona, Francesco Stefano, additional, Cools, Filip, additional, Farrugia, Ryan, additional, Ghirardello, Stefano, additional, Lozar, Jana, additional, Matasova, Katarina, additional, Muehlbacher, Tobias, additional, Sankilampi, Ulla, additional, Soares, Henrique, additional, Szabo, Miklos, additional, Szczapa, Tomasz, additional, Zaharie, Gabriela, additional, Roehr, Charles Christoph, additional, and Fustolo-Gunnink, Suzanne, additional

Published
2023
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40. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years’ corrected age: follow-up of a randomised clinical trial

Author

Halbmeijer, Nienke Marjolein, primary, Onland, Wes, additional, Cools, Filip, additional, Swarte, Renate M, additional, van der Heide-Jalving, Marja, additional, Dijk, Peter, additional, Mulder-de Tollenaer, Susanne, additional, Tan, Ratna N G B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, van Heijst, Arno F J, additional, Kramer, Boris, additional, Debeer, Anne, additional, van Weissenbruch, Mirjam M, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Offringa, Martin, additional, van Wassenaer-Leemhuis, Aleid G, additional, van Kaam, Anton H, additional, and Aarnoudse-Moens, Cornelieke S H, additional

Published
2023
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42. Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

Author

Hundscheid, Tim, Onland, Wes, van Overmeire, Bart, Dijk, Peter, van Kaam, Anton H. L. C., Dijkman, Koen P., Kooi, Elisabeth M. W., Villamor, Eduardo, Kroon, André A., Visser, Remco, Vijlbrief, Daniel C., de Tollenaer, Susanne M., Cools, Filip, van Laere, David, Johansson, Anne-Britt, Hocq, Catheline, Zecic, Alexandra, Adang, Eddy, Donders, Rogier, de Vries, Willem, van Heijst, Arno F. J., and de Boode, Willem P.

Published
2018
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46. Efficacy and Safety of Enteral Recombinant Human Insulin in Preterm Infants

Author

FIT-04 Study Group, Mank, Elise, Sáenz de Pipaón, Miguel, Lapillonne, Alexandre, Carnielli, Virgilio P, Senterre, Thibault, Shamir, Raanan, van Toledo, Letty, van Goudoever, Johannes B, Cools, Filip, UZB Other, Clinical sciences, Growth and Development, Neonatology, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development

Subjects
Male, Milk, Human, Infant, Newborn, Infant, Preterm infants, Enteral Recombinant Human Insulin, Enteral Nutrition, Enterocolitis, Necrotizing, Pediatrics, Perinatology and Child Health, Birth Weight, Humans, Insulin, Female, clinical trail, Pediatrics, Perinatology, and Child Health, Infant, Premature
Abstract

Importance: Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears to promote intestinal maturation. The insulin concentration in human milk declines rapidly post partum and insulin is absent in formula; therefore, recombinant human (rh) insulin for enteral administration as a supplement to human milk and formula may reduce feeding intolerance in preterm infants. Objective: To assess the efficacy and safety of 2 different dosages of rh insulin as a supplement to both human milk and preterm formula. Design, Setting, and Participants: The FIT-04 multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at 46 neonatal intensive care units throughout Europe, Israel, and the US. Preterm infants with a gestational age (GA) of 26 to 32 weeks and a birth weight of 500 g or more were enrolled between October 9, 2016, and April 25, 2018. Data were analyzed in January 2020. Interventions: Preterm infants were randomly assigned to receive low-dose rh insulin (400-μIU/mL milk), high-dose rh insulin (2000-μIU/mL milk), or placebo for 28 days. Main Outcomes and Measures: The primary outcome was time to achieve full enteral feeding (FEF) defined as an enteral intake of 150 mL/kg per day or more for 3 consecutive days. Results: The final intention-to-treat analysis included 303 preterm infants (low-dose group: median [IQR] GA, 29.1 [28.1-30.4] weeks; 65 boys [59%]; median [IQR] birth weight, 1200 [976-1425] g; high-dose group: median [IQR] GA, 29.0 [27.7-30.5] weeks; 52 boys [55%]; median [IQR] birth weight, 1250 [1020-1445] g; placebo group: median [IQR] GA, 28.8 [27.6-30.4] weeks; 54 boys [55%]; median [IQR] birth weight, 1208 [1021-1430] g). The data safety monitoring board advised to discontinue the study early based on interim futility analysis (including the first 225 randomized infants), as the conditional power did not reach the prespecified threshold of 35% for both rh-insulin dosages. The study continued while the data safety monitoring board analyzed and discussed the data. In the final intention-to-treat analysis, the median (IQR) time to achieve FEF was significantly reduced in 94 infants receiving low-dose rh insulin (10.0 [7.0-21.8] days; P = .03) and in 82 infants receiving high-dose rh insulin (10.0 [6.0-15.0] days; P = .001) compared with 85 infants receiving placebo (14.0 [8.0-28.0] days). Compared with placebo, the difference in median (95% CI) time to FEF was 4.0 (1.0-8.0) days for the low-dose group and 4.0 (1.0-7.0) days for the high-dose group. Weight gain rates did not differ significantly between groups. Necrotizing enterocolitis (Bell stage 2 or 3) occurred in 7 of 108 infants (6%) in the low-dose group, 4 of 88 infants (5%) in the high-dose group, and 10 of 97 infants (10%) in the placebo group. None of the infants developed serum insulin antibodies. Conclusions and Relevance: Results of this randomized clinical trial revealed that enteral administration of 2 different rh-insulin dosages was safe and compared with placebo, significantly reduced time to FEF in preterm infants with a GA of 26 to 32 weeks. These findings support the use of rh insulin as a supplement to human milk and preterm formula. Trial Registration: ClinicalTrials.gov Identifier: NCT02510560.

Published
2022

47. Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate

Author

Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans-Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M, El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E, Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow-Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L, McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P, Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N, Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, and Zhou, Lindsay

Subjects
Infant, Newborn, Brain, Humans, Head, Neuroprotection
Abstract

ispartof: J Neonatal Perinatal Med vol:15 issue:2 pages:427-439 ispartof: location:Netherlands status: published

Published
2022

48. Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate

Author

MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M., El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E., Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L., McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P., Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N., Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, Zhou, Lindsay, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M., El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E., Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L., McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P., Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N., Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, and Zhou, Lindsay

Published
2022

49. Short-term pulmonary and systemic effects of hydrocortisone initiated 7–14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial

Author

Halbmeijer, Nienke M, primary, Onland, Wes, additional, Cools, Filip, additional, Kroon, Andre, additional, van der Heide-Jalving, Marja, additional, Dijk, Peter, additional, van Straaten, Henrica L M, additional, te Pas, Arjan B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, van Heijst, Arno F J, additional, Kramer, Boris, additional, Debeer, Anne, additional, Zonnenberg, Inge A, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Merkus, Maruschka P, additional, Offringa, Martin, additional, and van Kaam, Anton H, additional

Published
2022
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50. End-of-life decisions in neonates and infants: a nationwide mortality follow-back survey

Author

Dombrecht, Laure, primary, Beernaert, Kim, additional, Chambaere, Kenneth, additional, Cools, Filip, additional, Goossens, Linde, additional, Naulaers, Gunnar, additional, Cornette, Luc, additional, Laroche, Sabrina, additional, Theyskens, Claire, additional, Vandeputte, Christine, additional, Van de Broek, Hilde, additional, Cohen, Joachim, additional, and Deliens, Luc, additional

Published
2022
Full Text
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