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360 results on '"Conklin Bruce R"'

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2. Transcription factor protein interactomes reveal genetic determinants in heart disease

5. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

6. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.

7. Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

8. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.

9. Rapid, precise quantification of large DNA excisions and inversions by ddPCR.

10. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

11. CRISPR off-target detection with DISCOVER-seq

12. Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.

13. Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity

14. AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design

15. Automated Design of Pluripotent Stem Cell Self-Organization

16. Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells

17. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes

18. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

19. MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification

20. Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

21. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

22. Quantitatively characterizing drug‐induced arrhythmic contractile motions of human stem cell‐derived cardiomyocytes

23. Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells

24. Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR

25. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision

26. Bioengineered optogenetic model of human neuromuscular junction

28. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

29. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes

30. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

31. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

32. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence

33. Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell–Derived Cardiac Progenitors

35. Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

36. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

37. Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.

38. Generating trunk neural crest from human pluripotent stem cells.

39. Efficient CRISPR/Cas9‐Based Genome Engineering in Human Pluripotent Stem Cells

40. Self-organizing human cardiac microchambers mediated by geometric confinement.

41. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

42. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

43. A Non-invasive Platform for Functional Characterization of Stem-Cell-Derived Cardiomyocytes with Applications in Cardiotoxicity Testing

44. Human iPSC-based cardiac microphysiological system for drug screening applications.

45. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.

47. Dual α-globin and truncated erythropoietin receptor knock-in restores hemoglobin production in α-thalassemia major-derived hematopoietic stem and progenitor cells

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