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7. Evaluation of Intracardiac Pressures Using Subharmonic-aided Pressure Estimation with Sonazoid Microbubbles

Author

Esposito, Cara, primary, Machado, Priscilla, additional, McDonald, Maureen E., additional, Savage, Michael P., additional, Fischman, David, additional, Mehrotra, Praveen, additional, Cohen, Ira S., additional, Ruggiero, Nicholas, additional, Walinsky, Paul, additional, Vishnevsky, Alec, additional, Dickie, Kristopher, additional, Davis, Marguerite, additional, Forsberg, Flemming, additional, and Dave, Jaydev K., additional

Published
2024
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14. Contributors

Author

Aagaard, Philip, primary, Abrams, Dominic James, additional, Abriel, Hugues, additional, Adkisson, Wayne O., additional, Agullo-Pascual, Esperanza, additional, Alvarado, Francisco J., additional, Amin, Ahmad S., additional, Antzelevitch, Charles, additional, Anumonwo, Justus M.B., additional, Armaganijan, Luciana, additional, Arya, Arash, additional, Asirvatham, Samuel, additional, Atienza, Felipe, additional, Backx, Peter H., additional, Ballou, Lisa M., additional, Balse, Elise, additional, Balulad, Sujata, additional, Barbuti, Andrea, additional, Bardy, Gust H., additional, Bassil, Guillaume, additional, Benditt, David G., additional, Berenfeld, Omer, additional, Bers, Donald M., additional, Binah, Ofer, additional, Bogun, Frank, additional, Bongianino, Rossana, additional, Boyle, Noel G., additional, Boyle, Patrick M., additional, Breithardt, Günter, additional, Brini, Marisa, additional, Brink, Peter R., additional, Brugada, Pedro, additional, Buch, Eric, additional, Bukauskas, Feliksas F., additional, Calkins, Hugh, additional, Callans, David J., additional, Caples, Sean M., additional, Carafoli, Ernesto, additional, Catterall, William A., additional, Cerrone, Marina, additional, Chaumeil, Arnaud, additional, Chen, Caressa, additional, Chen, Lan S., additional, Chen, Peng-Sheng, additional, Cheng, Jianding, additional, Chiamvimonvat, Nipavan, additional, Christini, David J., additional, Chugh, Aman, additional, Climent, Andreu M., additional, Cohen, Ira S., additional, Connolly, Stuart J., additional, Cooper, Lebron, additional, Crespo, Eric M., additional, Crotti, Lia, additional, Csepe, Thomas A., additional, Cuoco, Frank, additional, Curtis, Anne B., additional, Damiano, Ralph J., additional, Darbar, Dawood, additional, Das, Mithilesh K., additional, d’Avila, Andre, additional, Delmar, Mario, additional, Delpón, Eva, additional, Denegri, Marco, additional, Denis, Arnaud, additional, Derval, Nicolas, additional, Deschênes, Isabelle, additional, Deshmukh, Abhishek, additional, Di Biase, Luigi, additional, Dickfeld, Timm M., additional, Dierckx, Hans, additional, Dinov, Borislav, additional, Dixit, Sanjay, additional, Dobrev, Dobromir, additional, Dubois, Remi, additional, Eckardt, Lars, additional, Edwards, Andrew G., additional, Ellenbogen, Kenneth A., additional, Ellinor, Patrick T., additional, Estes, N.A. Mark, additional, Fabritz, Larissa, additional, Fedorov, Vadim V., additional, Fernandez, Antonio B., additional, Teijeira Fernández, Elvis, additional, Filgueiras-Rama, David, additional, Fishbein, Michael C., additional, Fishman, Glenn I., additional, Frankel, David S., additional, Friedman, Paul, additional, Frontera, Antonio, additional, Gami, Apoor S., additional, Garabelli, Paul, additional, George, Alfred L., additional, Gerstenfeld, Edward P., additional, Gizurarson, Sigfus, additional, Gold, Michael R., additional, Goldberger, Jeffrey J., additional, Grace, Andrew, additional, Grassi, Guido, additional, Greenfield, Ruth Ann, additional, Gross, Wendy L., additional, Grubb, Blair P., additional, Guillem, María S., additional, Györke, Sándor, additional, Haïssaguerre, Michel, additional, Hake, Johan, additional, Halperin, Henry R., additional, Hansen, Brian J., additional, Hatem, Stéphane, additional, Hayes, David L., additional, Heijman, Jordi, additional, Herron, Todd J., additional, Hindricks, Gerhard, additional, Hocini, Mélèze, additional, Hohnloser, Stefan H., additional, Holmes, David R., additional, Hoshijima, Masahiko, additional, Hund, Thomas J., additional, Hutchinson, Mathew D., additional, Ilkhanoff, Leonard, additional, Ingles, Jodie, additional, Ip, James E., additional, Jackman, Warren M., additional, Jackson, Nicholas, additional, Jaïs, Pierre, additional, Jalife, José, additional, Jhun, Bong Sook, additional, John, Roy M., additional, Jongbloed, Monique, additional, Jordaens, Luc, additional, Kalman, Jonathan M., additional, Kamp, Timothy J., additional, Kanj, Mohamed H., additional, Kapa, Suraj, additional, Karabin, Beverly, additional, Karakikes, Ioannis, additional, Katritsis, Demosthenes G., additional, Kaur, Kuljeet, additional, Kirchhof, Paulus, additional, Kléber, André G., additional, Klein, George J., additional, Kohl, Peter, additional, Koneru, Jayanthi N., additional, Koruth, Jacob S., additional, Krahn, Andrew D., additional, Krogh-Madsen, Trine, additional, Kuck, Karl Heinz, additional, Kumar, Saurabh, additional, Kushnir, Alexander, additional, Lakdawala, Neal K., additional, Laksman, Zachary W.M., additional, Latchamsetty, Rakesh, additional, Lau, Dennis H., additional, Lerman, Bruce B., additional, Lin, Richard Z., additional, Lin, Shien-Fong, additional, Link, Mark S., additional, Liu, Bin, additional, Liu, Christopher F., additional, Lockwood, Deborah J., additional, Lopatin, Anatoli N., additional, Lubitz, Steven A., additional, Mahajan, Rajiv, additional, Makielski, Jonathan C., additional, Malik, Marek, additional, Marchlinski, Francis E., additional, Markowitz, Steven M., additional, Maron, Barry J., additional, Maron, Martin S., additional, Marx, Steven O., additional, Massé, Stéphane, additional, McCulloch, Andrew D., additional, McKelvie-Sebileau, Pippa, additional, Melby, Spencer J., additional, Metzner, Andreas, additional, Michailova, Anushka P., additional, Michaud, Gregory F., additional, Miller, John M., additional, Mishra, Jyotsna, additional, Mitrani, Raul D., additional, Mohler, Peter J., additional, Morady, Fred, additional, Myerburg, Robert J., additional, Nakagawa, Hiroshi, additional, Nalliah, Chrishan Joseph, additional, Nanthakumar, Kumaraswamy, additional, Napolitano, Carlo, additional, Narayan, Sanjiv M., additional, Natale, Andrea, additional, Nattel, Stanley, additional, Nazarian, Saman, additional, Nguyen, Thao P., additional, Nogami, Akihiko, additional, Noujaim, Sami F., additional, Nubret Le Coniat, Karine, additional, Olshansky, Brian, additional, O-Uchi, Jin, additional, Oudit, Gavin Y., additional, Ouyang, Feifan, additional, Ozcan, Cevher, additional, Packer, Douglas L., additional, Pandit, Sandeep V., additional, Panfilov, Alexander V., additional, Park, David S., additional, Patocskai, Bence, additional, Pauza, Dainius H., additional, Pauziene, Neringa, additional, Piccini, Jonathan P., additional, Pitt, Geoffrey S., additional, Po, Sunny S., additional, Prasad, Abhiram, additional, Priori, Silvia G., additional, Radwański, Przemysław B., additional, Rappel, Wouter-Jan, additional, Reiser, Michelle, additional, Restrepo, Alejandro Jimenez, additional, Robinson, Richard B., additional, Roden, Dan M., additional, Rosen, Michael R., additional, Rosso, Raphael, additional, Rudy, Yoram, additional, Rysevaite-Kyguoliene, Kristina, additional, Sabbah, Hani N., additional, Sacher, Frederic, additional, Sachse, Frank B., additional, Saguner, Ardan M., additional, Sanders, Prashanthan, additional, Sanguinetti, Michael C., additional, Santangeli, Pasquale, additional, Sarraf, Mohammad, additional, Satin, Jonathan, additional, Schalij, Martin Jan, additional, Scherlag, Benjamin J., additional, Schill, Matthew R., additional, Schleifer, J. William, additional, Schuessler, Richard B., additional, Schwartz, Peter J., additional, Seeger, Timon, additional, Semsarian, Christopher, additional, Seravalle, Gino, additional, Shah, Ashok J., additional, Shaw, Robin M., additional, Shen, Mark J., additional, Shen, Win–Kuang, additional, Sheu, Shey-Shing, additional, Shivkumar, Kalyanam, additional, Silva, Jennifer N.A., additional, Skanes, Allan C., additional, Soejima, Kyoko, additional, Somers, Virend K., additional, Sorajja, Dan, additional, Stavrakis, Stavros, additional, Steinberg, Christian, additional, Stevenson, Lynne Warner, additional, Stevenson, William G., additional, Sweeney, Michael O., additional, Swerdlow, Charles, additional, Takigawa, Masateru, additional, Tamargo, Juan, additional, Tandri, Harikrishna, additional, Tedrow, Usha B., additional, Thompson, Nathaniel, additional, Thompson, Paul D., additional, Tomaselli, Gordon F., additional, Towbin, Jeffrey A., additional, Trayanova, Natalia A., additional, Tristani-Firouzi, Martin, additional, Tseng, Zian H., additional, Ueda, Akiko, additional, Valdivia, Héctor H., additional, Valiunas, Virginijus, additional, van der Werf, Christian, additional, Van Hare, George F., additional, Vidmar, David, additional, Viskin, Sami, additional, Voigt, Niels, additional, Walsh, Edward P., additional, Wang, Paul J., additional, Wehrens, Xander H.T., additional, Weiss, Mark S., additional, Wilde, Arthur A.M., additional, Wilkoff, Bruce L., additional, Woo, Y. Joseph, additional, Wu, Joseph C., additional, Yee, Raymond, additional, Zaman, Junaid A.B., additional, Zarzoso, Manuel, additional, Zeitler, Emily P., additional, Zeppenfeld, Katja, additional, Zghaib, Tarek, additional, Zhang, Xiao-Dong, additional, and Zipes, Douglas P., additional

Published
2018
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16. Noninvasive Evaluation of Cardiac Chamber Pressures Using Subharmonic-Aided Pressure Estimation With Definity Microbubbles

Author

Esposito, Cara, primary, Machado, Priscilla, additional, McDonald, Maureen E., additional, Savage, Michael P., additional, Fischman, David, additional, Mehrotra, Praveen, additional, Cohen, Ira S., additional, Ruggiero, Nicholas, additional, Walinsky, Paul, additional, Vishnevsky, Alec, additional, Dickie, Kristopher, additional, Davis, Marguerite, additional, Forsberg, Flemming, additional, and Dave, Jaydev K., additional

Published
2022
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17. Comparing Central Aortic Pressures Obtained Using a SphygmoCor Device to Pressures Obtained Using a Pressure Catheter

Author

Esposito, Cara, primary, Machado, Priscilla, additional, Cohen, Ira S, additional, Mehrotra, Praveen, additional, Savage, Michael, additional, Fischman, David, additional, Davis, Marguerite, additional, Ruggiero, Nicholas, additional, Walinsky, Paul, additional, McDonald, Maureen E, additional, Dickie, Kristopher, additional, Forsberg, Flemming, additional, and Dave, Jaydev K, additional

Published
2022
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19. Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Author

Lin, Yangyang, primary, Grinter, Sam Z., additional, Lu, Zhongju, additional, Xu, Xianjin, additional, Wang, Hong Zhan, additional, Liang, Hongwu, additional, Hou, Panpan, additional, Gao, Junyuan, additional, Clausen, Chris, additional, Shi, Jingyi, additional, Zhao, Wenshan, additional, Ma, Zhiwei, additional, Liu, Yongfeng, additional, White, Kelli McFarland, additional, Zhao, Lu, additional, Kang, Po Wei, additional, Zhang, Guohui, additional, Cohen, Ira S., additional, Zou, Xiaoqin, additional, and Cui, Jianmin, additional

Published
2021
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25. Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects.

Author

Yangyang Lin, Grinter, Sam Z., Zhongju Lu, Xianjin Xu, Hong Zhan Wang, Hongwu Liang, Panpan Hou, Junyuan Gao, Chris Clausen, Jingyi Shi, Wenshan Zhao, Zhiwei Ma, Yongfeng Liu, White, Kelli McFarland, Lu Zhao, Po Wei Kang, Guohui Zhang, Cohen, Ira S., Xiaoqin Zou, and Jianmin Cui

Subjects
POTASSIUM channels, ARRHYTHMIA, VENTRICULAR arrhythmia, CARDIAC arrest, VOLTAGE
Abstract

Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular arrhythmia, Torsade de Pointes. IKs (KCNQ1+KCNE1), a slowly activating K+ current, plays a role in action potential repolarization. In this study, we screened a chemical library in silico by docking compounds to the voltage-sensing domain (VSD) of the IKs channel. Here, we show that C28 specifically shifted IKs VSD activation in ventricle to more negative voltages and reversed the drug-induced lengthening of APD. At the same dosage, C28 did not cause significant changes of the normal APD in either ventricle or atrium. This study provides evidence in support of a computational prediction of IKs VSD activation as a potential therapeutic approach for all forms of APD prolongation. This outcome could expand the therapeutic efficacy of a myriad of currently approved drugs that may trigger arrhythmias. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Induced Pluripotent Stem Cell–Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function

Author

Chauveau, Samuel, primary, Anyukhovsky, Evgeny P., additional, Ben-Ari, Meital, additional, Naor, Shulamit, additional, Jiang, Ya-Ping, additional, Danilo, Peter, additional, Rahim, Tania, additional, Burke, Stephanie, additional, Qiu, Xiaoliang, additional, Potapova, Irina A., additional, Doronin, Sergey V., additional, Brink, Peter R., additional, Binah, Ofer, additional, Cohen, Ira S., additional, and Rosen, Michael R., additional

Published
2017
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29. CP1 Opens I Ks Channels by Substituting PIP 2

Author

Naffaa, Moawiah M., primary, Xu, Xianjin, additional, Liang, Hongwu, additional, Zhang, Guohui, additional, Zhan Wang, Hong, additional, Goa, Junyuan, additional, Cohen, Ira S., additional, Zou, Xiaoqin, additional, and Cui, Jianmin, additional

Published
2017
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30. Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration

Author

Qiu, Xiaoliang S., Chauveau, Samuel, Anyukhovsky, Evgeny P., Rahim, Tania, Jiang, Ya Ping, Harleton, Erin, Feinmark, Steven J., Lin, Richard Z., Coronel, Ruben, Janse, Michiel J., Opthof, Tobias, Rosen, Tove S., Cohen, Ira S., Rosen, Michael R., Qiu, Xiaoliang S., Chauveau, Samuel, Anyukhovsky, Evgeny P., Rahim, Tania, Jiang, Ya Ping, Harleton, Erin, Feinmark, Steven J., Lin, Richard Z., Coronel, Ruben, Janse, Michiel J., Opthof, Tobias, Rosen, Tove S., Cohen, Ira S., and Rosen, Michael R.

Published
2016

31. Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration

Author

Medische Fysiologie, Circulatory Health, Qiu, Xiaoliang S., Chauveau, Samuel, Anyukhovsky, Evgeny P., Rahim, Tania, Jiang, Ya Ping, Harleton, Erin, Feinmark, Steven J., Lin, Richard Z., Coronel, Ruben, Janse, Michiel J., Opthof, Tobias, Rosen, Tove S., Cohen, Ira S., Rosen, Michael R., Medische Fysiologie, Circulatory Health, Qiu, Xiaoliang S., Chauveau, Samuel, Anyukhovsky, Evgeny P., Rahim, Tania, Jiang, Ya Ping, Harleton, Erin, Feinmark, Steven J., Lin, Richard Z., Coronel, Ruben, Janse, Michiel J., Opthof, Tobias, Rosen, Tove S., Cohen, Ira S., and Rosen, Michael R.

Published
2016

32. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration

Author

Qiu, Xiaoliang S., primary, Chauveau, Samuel, additional, Anyukhovsky, Evgeny P., additional, Rahim, Tania, additional, Jiang, Ya-Ping, additional, Harleton, Erin, additional, Feinmark, Steven J., additional, Lin, Richard Z., additional, Coronel, Ruben, additional, Janse, Michiel J., additional, Opthof, Tobias, additional, Rosen, Tove S., additional, Cohen, Ira S., additional, and Rosen, Michael R., additional

Published
2016
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33. Abstract 11490: Increased Late Sodium Current Contributes to Excess Prolongation of Canine Ventricular Repolarization Induced by Dofetilide

Author

Qiu, Xiaoliang(Shawn), primary, Chauveau, Samuel, additional, Evgeny, Anyukhovsky P, additional, Rahim, Tania, additional, Jiang, Ya-Ping, additional, Harleton, Erin R, additional, Feinmark, Steven J, additional, Lin, Richard Z, additional, Rosen, Tove S, additional, Cohen, Ira S, additional, and Rosen, Michael R, additional

Published
2015
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38. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

Author

Xiaoliang S. Qiu, Chauveau, Samuel, Anyukhovsky, Evgeny P., Rahim, Tania, Ya-Ping Jiang, Harleton, Erin, Feinmark, Steven J., Lin, Richard Z., Coronel, Ruben, Janse, Michiel J., Opthof, Tobias, Rosen, Tove S., Cohen, Ira S., Rosen, Michael R., Qiu, Xiaoliang S, and Jiang, Ya-Ping

Subjects
SODIUM metabolism, ANIMAL experimentation, BIOLOGICAL models, CYTOLOGICAL techniques, DOGS, DOSE-effect relationship in pharmacology, ELECTROPHYSIOLOGY, HEART ventricles, INTRAVENOUS therapy, PHENETHYLAMINES, RESEARCH funding, SULFONAMIDES, LONG QT syndrome, POTASSIUM antagonists
Abstract

Background: Drugs are screened for delayed rectifier potassium current (IKr) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some IKr blockers (eg, dofetilide) prolongs repolarization additionally by increasing late sodium current (INa-L) via inhibition of phosphoinositide 3-kinase. We hypothesized that chronic dofetilide administration to intact dogs prolongs repolarization by blocking IKr and increasing INa-L.Methods and Results: We continuously infused dofetilide (6-9 μg/kg bolus+6-9 μg/kg per hour IV infusion) into anesthetized dogs for 7 hours, maintaining plasma levels within the therapeutic range. In separate experiments, myocardial biopsies were taken before and during 6-hour intravenous dofetide infusion, and the level of phospho-Akt was determined. Acute and chronic dofetilide effects on action potential duration (APD) were studied in canine left ventricular subendocardial slabs using microelectrode techniques. Dofetilide monotonically increased QTc and APD throughout 6.5-hour exposure. Dofetilide infusion during ≥210 minutes inhibited Akt phosphorylation. INa-L block with lidocaine shortened QTc and APD more at 6.5 hours than at 50 minutes (QTc) or 30 minutes (APD) dofetilide administration. In comparison, moxifloxacin, an IKr blocker with no effects on phosphoinositide 3-kinase and INa-L prolonged APD acutely but no additional prolongation occurred on chronic superfusion. Lidocaine shortened APD equally during acute and chronic moxifloxacin superfusion.Conclusions: Increased INa-L contributes to chronic dofetilide effects in vivo. These data emphasize the need to include time and INa-L in evaluating the phosphoinositide 3-kinase inhibition-derived proarrhythmic potential of drugs and provide a mechanism for benefit from lidocaine administration in clinical acquired long QT syndrome. [ABSTRACT FROM AUTHOR]

Published
2016
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39. Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells.

Author

Hong Zhan Wang, Rosati, Barbara, Gordon, Chris, Valiunas, Virginijus, McKinnon, David, Cohen, Ira S., Brink, Peter R., Michel, Martin C., and Almeida-Porada, Graça

Subjects
PHENYL compounds, BUTYRATES, CONNEXINS, MESSENGER RNA, PROTEIN research
Abstract

4-phenylbutyrate (4-PB) has been shown to increase the protein content in a number of cells types. One such protein is Connexin43 (Cx43). We show here that 4-phenylbutyrate exposure results in significantly elevated cell to cell coupling, as determined by dual whole cell patch clamp. Incubation with 5mM 4PB for 24 h or more nearly doubles junctional conductance. Interestingly, mRNA levels for Cx43 declined with exposure to 4-PB while western blot analysis revealed not significant change in protein levels. These data are most consistent with stabilization of the existing Cx43 pool or alterations in the number of functional channels within an existing pool of active and silent channels. These data represent a baseline for testing the efficacy of increased connexin mediated coupling in a variety of multicellular functions including erectile function. [ABSTRACT FROM AUTHOR]

Published
2015
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42. The fully activated open state of KCNQ1 controls the cardiac "fight-or-flight" response.

Author

Hou P, Zhao L, Zhong L, Shi J, Wang HZ, Gao J, Liu H, Zuckerman J, Cohen IS, and Cui J

Abstract

The cardiac KCNQ1 + KCNE1 (I Ks ) channel regulates heart rhythm under both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cyclic adenosine monophosphate (cAMP) level, leading to KCNQ1 phosphorylation by protein kinase A and increased I Ks , which shortens action potentials to adapt to accelerated heart rate. An impaired response to the β-adrenergic stimulation due to KCNQ1 mutations is associated with the occurrence of a lethal congenital long QT syndrome (type 1, also known as LQT1). However, the underlying mechanism of β-adrenergic stimulation of I Ks remains unclear, impeding the development of new therapeutics. Here, we find that the unique properties of KCNQ1 channel gating with two distinct open states are key to this mechanism. KCNQ1's fully activated open (AO) state is more sensitive to cAMP than its intermediate open state. By enhancing the AO state occupancy, the small molecules ML277 and C28 are found to effectively enhance the cAMP sensitivity of the KCNQ1 channel, independent of KCNE1 association. This finding of enhancing AO state occupancy leads to a potential novel strategy to rescue the response of I Ks to β-adrenergic stimulation in LQT1 mutants. The success of this approach is demonstrated in cardiac myocytes and also in a high-risk LQT1 mutation. In conclusion, the present study not only uncovers the key role of the AO state in I Ks channel phosphorylation, but also provides a target for antiarrhythmic strategy., (© The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.)

Published
2024
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