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32 results on '"Ciampa, Maria"'

1. GM1 structural requirements to mediate neuronal functions

Author

Fazzari, Maria, Lunghi, Giulia, Di Biase, Erika, Maggioni, Margherita, Carsana, Emma Veronica, Cioccarelli, Laura, Vigani, Laura, Loberto, Nicoletta, Aureli, Massimo, Mauri, Laura, Ciampa, Maria Grazia, Valsecchi, Manuela, Takato, Koichi, Imamura, Akihiro, Ishida, Hideharu, Ben Mariem, Omar, Saporiti, Simona, Palazzolo, Luca, Chiricozzi, Elena, Eberini, Ivano, and Sonnino, Sandro

Published
2023
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5. GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation.

Author

Fazzari, Maria, Lunghi, Giulia, Carsana, Emma Veronica, Valsecchi, Manuela, Spiombi, Eleonora, Breccia, Martina, Casati, Silvia Rosanna, Pedretti, Silvia, Mitro, Nico, Mauri, Laura, Ciampa, Maria Grazia, Sonnino, Sandro, Landsberger, Nicoletta, Frasca, Angelisa, and Chiricozzi, Elena

Subjects
CELL receptors, RETT syndrome, CELL membranes, NERVOUS system, OXIDATIVE stress
Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene. Despite advancements in research, no cure exists due to an incomplete understanding of the molecular effects of MeCP2 deficiency. Previous studies have identified impaired tropomyosin receptor kinase (Trk) neurotrophin (NTP) signaling and mitochondrial redox imbalances as key drivers of the pathology. Moreover, altered glycosphingolipid metabolism has been reported in RTT. GM1 ganglioside is a known regulator of the nervous system, and growing evidence indicates its importance in maintaining neuronal homeostasis via its oligosaccharide chain, coded as GM1-OS. GM1-OS directly interacts with the Trk receptors on the cell surface, triggering neurotrophic and neuroprotective pathways in neurons. In this study, we demonstrate that GM1-OS ameliorates RTT deficits in the Mecp2-null model. GM1-OS restored synaptogenesis and reduced mitochondrial oxidative stress of Mecp2-knock-out (ko) cortical neurons. When administered in vivo, GM1-OS mitigated RTT-like symptoms. Our findings indicate that GM1-OS effects were mediated by Trk receptor activation on the neuron's plasma membrane. Overall, our results highlight GM1-OS as a promising candidate for RTT treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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8. GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

Author

Lunghi, Giulia, primary, Di Biase, Erika, additional, Carsana, Emma Veronica, additional, Henriques, Alexandre, additional, Callizot, Noelle, additional, Mauri, Laura, additional, Ciampa, Maria Grazia, additional, Mari, Luigi, additional, Loberto, Nicoletta, additional, Aureli, Massimo, additional, Sonnino, Sandro, additional, Spedding, Michael, additional, Chiricozzi, Elena, additional, and Fazzari, Maria, additional

Published
2023
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10. Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity

Author

Kanoh, Hirotaka, Nitta, Takahiro, Go, Shinji, Inamori, Kei‐ichiro, Veillon, Lucas, Nihei, Wataru, Fujii, Mayu, Kabayama, Kazuya, Shimoyama, Atsushi, Fukase, Koichi, Ohto, Umeharu, Shimizu, Toshiyuki, Watanabe, Taku, Shindo, Hiroki, Aoki, Sorama, Sato, Kenichi, Nagasaki, Mika, Yatomi, Yutaka, Komura, Naoko, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto, Natori, Yoshihiro, Yoshimura, Yuichi, Zonca, Asia, Cattaneo, Anna, Letizia, Marilena, Ciampa, Maria, Mauri, Laura, Prinetti, Alessandro, Sonnino, Sandro, Suzuki, Akemi, and Inokuchi, Jin‐ichi

Published
2020
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13. GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP

Author

Fazzari, Maria, primary, Lunghi, Giulia, additional, Henriques, Alexandre, additional, Callizot, Noëlle, additional, Ciampa, Maria Grazia, additional, Mauri, Laura, additional, Prioni, Simona, additional, Carsana, Emma Veronica, additional, Loberto, Nicoletta, additional, Aureli, Massimo, additional, Mari, Luigi, additional, Sonnino, Sandro, additional, Chiricozzi, Elena, additional, and Di Biase, Erika, additional

Published
2023
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22. Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity

Author

Kanoh, Hirotaka, primary, Nitta, Takahiro, additional, Go, Shinji, additional, Inamori, Kei‐ichiro, additional, Veillon, Lucas, additional, Nihei, Wataru, additional, Fujii, Mayu, additional, Kabayama, Kazuya, additional, Shimoyama, Atsushi, additional, Fukase, Koichi, additional, Ohto, Umeharu, additional, Shimizu, Toshiyuki, additional, Watanabe, Taku, additional, Shindo, Hiroki, additional, Aoki, Sorama, additional, Sato, Kenichi, additional, Nagasaki, Mika, additional, Yatomi, Yutaka, additional, Komura, Naoko, additional, Ando, Hiromune, additional, Ishida, Hideharu, additional, Kiso, Makoto, additional, Natori, Yoshihiro, additional, Yoshimura, Yuichi, additional, Zonca, Asia, additional, Cattaneo, Anna, additional, Letizia, Marilena, additional, Ciampa, Maria, additional, Mauri, Laura, additional, Prinetti, Alessandro, additional, Sonnino, Sandro, additional, Suzuki, Akemi, additional, and Inokuchi, Jin‐ichi, additional

Published
2020
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23. GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route

Author

Di Biase, Erika, primary, Lunghi, Giulia, additional, Maggioni, Margherita, additional, Fazzari, Maria, additional, Pomè, Diego Yuri, additional, Loberto, Nicoletta, additional, Ciampa, Maria Grazia, additional, Fato, Pamela, additional, Mauri, Laura, additional, Sevin, Emmanuel, additional, Gosselet, Fabien, additional, Sonnino, Sandro, additional, and Chiricozzi, Elena, additional

Published
2020
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24. Productivity-Based Wages and Employment of People With Disabilities: International Usage and Policy Considerations.

Author

Lysaght, Rosemary, Bobbette, Nicole, and Ciampa, Maria Agostina

Subjects
CINAHL database, PSYCHOLOGY information storage & retrieval systems, EMPLOYMENT of people with disabilities, LABOR productivity, ETHICS, MEDICAL information storage & retrieval systems, MATHEMATICAL models, SYSTEMATIC reviews, DEBATE, DEVELOPMENTAL disabilities, LABOR laws, SOCIOECONOMIC factors, WAGES, GOVERNMENT policy, THEORY, EMPLOYEE rights, JOB satisfaction, LABOR market, LITERATURE reviews, CIVIL rights, MEDLINE, SUPPORTED employment
Abstract

The legal requirement for employers to compensate workers at standard market wages, even if their work falls below competitive levels, is cited as a barrier to job entry for people with high support needs. Productivity-based wage systems have been implemented in some jurisdictions with a goal of addressing this challenge by providing an option for paying workers at rates commensurate with work output. This scoping review explored the international use of productivity-based wage systems, the theoretical and practical arguments that have been advanced for and against productivity-based wage systems, and the relative impact of such policies on employment outcomes. The review followed the procedures outlined by Arksey and O'Malley and included papers published from 2008 to 2017. The search identified 27 papers that were pertinent to at least one of the research questions. Only three countries emerged in the literature as having discernable productivity-based wage policies: Australia, Israel, and the United States. Limited evaluative evidence was identified on the impact of productivity-based wage systems on employment outcomes. There is, however, a robust debate evident concerning the socioeconomic, moral, and legal implications of this practice. Ongoing research is needed to inform policy on this contentious issue. [ABSTRACT FROM AUTHOR]

Published
2021
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25. A lysosome‐plasma membrane‐sphingolipid axis linking lysosomal storage to cell growth arrest

Author

Samarani, Maura, primary, Loberto, Nicoletta, additional, Soldà, Giulia, additional, Straniero, Letizia, additional, Asselta, Rosanna, additional, Duga, Stefano, additional, Lunghi, Giulia, additional, Zucca, Fabio A., additional, Mauri, Laura, additional, Ciampa, Maria Grazia, additional, Schiumarini, Domitilla, additional, Bassi, Rosaria, additional, Giussani, Paola, additional, Chiricozzi, Elena, additional, Prinetti, Alessandro, additional, Aureli, Massimo, additional, and Sonnino, Sandro, additional

Published
2018
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26. A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

Author

Farinello, Diego, primary, Wozińska, Monika, additional, Lenti, Elisa, additional, Genovese, Luca, additional, Bianchessi, Silvia, additional, Migliori, Edoardo, additional, Sacchetti, Nicolò, additional, di Lillo, Alessia, additional, Bertilaccio, Maria Teresa Sabrina, additional, de Lalla, Claudia, additional, Valsecchi, Roberta, additional, Gleave, Sabrina Bascones, additional, Lligé, David, additional, Scielzo, Cristina, additional, Mauri, Laura, additional, Ciampa, Maria Grazia, additional, Scarfò, Lydia, additional, Bernardi, Rosa, additional, Lazarevic, Dejan, additional, Gonzalez-Farre, Blanca, additional, Bongiovanni, Lucia, additional, Campo, Elias, additional, Cerutti, Andrea, additional, Ponzoni, Maurilio, additional, Pattini, Linda, additional, Caligaris-Cappio, Federico, additional, Ghia, Paolo, additional, and Brendolan, Andrea, additional

Published
2018
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27. Lipid Rafts and Neurological Diseases

Author

Sonnino, Sandro, primary, Grassi, Sara, additional, Prioni, Simona, additional, Ciampa, Maria G, additional, Chiricozzi, Elena, additional, and Prinetti, Alessandro, additional

Published
2016
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30. Combined magnetic resonance imaging and high resolution spectroscopy approaches to study the fertilization effects on metabolome, morphology and yeast community of wine grape berries, cultivar Nero di Troia

Author

Luigi Tarricone, Anna Benedetti, Alessandra Ciampa, Francesco Capozzi, Alessia Trimigno, Gianfranco Picone, Domenico Di Gennaro, Alessandro Florio, Maria Teresa Dell'Abate, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Interdepartmental Centre for Industrial Agrofood Research, Alma Mater Studiorum-University of Bologna, and Alessandra Ciampa, Maria Teresa Dell'Abate, Alessandro Florio, Luigi Tarricone, Domenico Di Gennaro, Gianfranco Picone, Alessia Trimigno, Francesco Capozzi, Anna Benedetti

Subjects
Magnetic Resonance Spectroscopy, H-1 NMR metabolic profile, [SDV]Life Sciences [q-bio], Malates, grape berry yeasts, Wine, 01 natural sciences, Wine grape, Analytical Chemistry, chemistry.chemical_compound, 0404 agricultural biotechnology, Human fertilization, Grape berry yeast, Valine, Yeasts, grape berry morphology, Metabolome, Vitis, Cultivar, Proline, Amino Acids, Fertilizers, Minerals, Chemistry, MRI, Grape berry morphology, Fertilization, Grape berry yeasts, fungi, 010401 analytical chemistry, food and beverages, Agriculture, 04 agricultural and veterinary sciences, General Medicine, 1H NMR metabolic profile, Magnetic Resonance Imaging, 040401 food science, Yeast, 0104 chemical sciences, Horticulture, Italy, fertilization, Fruit, Malic acid, H NMR metabolic profile, Food Science
Abstract

International audience; Effects of fertilization practices, mineral (M) and organo-mineral (OM), on molecular composition of Nero di Troia cultivar grape berries was studied using conventional chemical analysis, Magnetic Resonance Imaging (MRI) and 1H NMR spectroscopy on intact berries and extracts, respectively, and through analysis of yeast species developed on grape skins. Plants vegetative status did not differ between the two fertilization practices, whereas some grape juice chemical characteristics differed in fertilized grapes. MRI provided information on grape berries morphology through weighted images depending on spin-spin (T2) and spin-lattice (T1) relaxation times. T1 values were the highest in OM grape berries. 1H NMR metabolic profile, combined with chemometric analysis, evidenced significant differences for some metabolites (valine, leucine, isoleucine, proline, and malic acid). Furthermore, higher frequency of yeasts genus Starmella sp., isolated from OM grape berries contributed to reinforcing the found results on the physiological response of wine grape Nero di Troia to fertilization.

Published
2019
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31. A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

Author

Luca Genovese, Andrea Cerutti, Maurilio Ponzoni, Cristina Scielzo, Sabrina Bascones Gleave, Claudia de Lalla, Edoardo Migliori, Linda Pattini, Lydia Scarfò, Laura Mauri, Dejan Lazarevic, Blanca Gonzalez-Farre, Elisa Lenti, Maria Grazia Ciampa, Paolo Ghia, Rosa Bernardi, Monika Wozińska, Nicolò Sacchetti, Diego Farinello, Lucia Bongiovanni, Federico Caligaris-Cappio, Elias Campo, Roberta Valsecchi, David Lligé, Maria Teresa Sabrina Bertilaccio, Silvia Bianchessi, Alessia di Lillo, Andrea Brendolan, Farinello, Diego, Wozińska, Monika, Lenti, Elisa, Genovese, Luca, Bianchessi, Silvia, Migliori, Edoardo, Sacchetti, Nicolò, Di Lillo, Alessia, Bertilaccio, Maria Teresa Sabrina, De Lalla, Claudia, Valsecchi, Roberta, Gleave, Sabrina Bascone, Lligé, David, Scielzo, Cristina, Mauri, Laura, Ciampa, Maria Grazia, Scarfò, Lydia, Bernardi, Rosa, Lazarevic, Dejan, Gonzalez-Farre, Blanca, Bongiovanni, Lucia, Campo, Elia, Cerutti, Andrea, Ponzoni, Maurilio, Pattini, Linda, Caligaris-Cappio, Federico, Ghia, Paolo, and Brendolan, Andrea

Subjects
0301 basic medicine, Male, Chemokine, Limfomes, Chronic lymphocytic leukemia, Retinoic acid, General Physics and Astronomy, chemistry.chemical_compound, Citoquines, Tumor Microenvironment, lcsh:Science, Coculture Technique, Multidisciplinary, biology, Chemistry (all), Gene Expression Regulation, Neoplastic, Leukemia, Chemokine secretion, Disease Progression, Cytokines, Female, Survival Analysi, Signal Transduction, Stromal cell, Science, Tretinoin, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Physics and Astronomy (all), Retinoids, medicine, Animals, Leucèmia limfocítica crònica, CXCL13, Tumor microenvironment, Retinoides, Biochemistry, Genetics and Molecular Biology (all), Animal, Stromal Cell, General Chemistry, medicine.disease, Chemokine CXCL13, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, Coculture Techniques, Mice, Inbred C57BL, 030104 developmental biology, chemistry, biology.protein, Cancer research, lcsh:Q, Stromal Cells
Abstract

In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lymphocytes induce the activation of retinoid acid synthesis and signaling in the microenvironment. Inhibition of RA-signaling in stromal cells causes deregulation of genes associated with adhesion, tissue organization and chemokine secretion including the B-cell chemokine CXCL13. Notably, reducing retinoic acid precursors from the diet or inhibiting RA-signaling through retinoid-antagonist therapy prolong survival by preventing dissemination of leukemia cells into lymphoid tissues. Furthermore, mouse and human leukemia cells could be distinguished from normal B-cells by their increased expression of Rarγ2 and RXRα, respectively. These findings establish a role for retinoids in murine CLL pathogenesis, and provide new therapeutic strategies to target the microenvironment and to control disease progression., The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.

Published
2018

32. Membrane lipid domains in the nervous system.

Author

Sonnino S, Aureli M, Mauri L, Ciampa MG, and Prinetti A

Subjects
Animals, Carbohydrate Sequence, Gangliosides chemistry, Gangliosides metabolism, Humans, Molecular Sequence Data, Signal Transduction, Membrane Microdomains metabolism, Nervous System metabolism
Abstract

The structural properties of the lipids forming biological membranes determine a very high level of lateral organization within membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into membrane lipid domains, now worldwide known as lipid rafts, acting as dynamic platforms for signal transduction, protein processing and membrane turnover. Many processes necessary to the correct functions of nervous system occur in lipid rafts and are dependent on lipid raft organization. Thus, an altered lipid composition frequently occurring in neurodegenerative diseases leads to anomalous lipid raft organization and then to deregulated cell signaling.

Published
2015
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