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33 results on '"Churchill, Duncan"'

1. Association of pregnancy with engagement in HIV care among women with HIV in the UK: a cohort study

Author

Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Apoola, Ade, Chadwick, David, Churchill, Duncan, Delpech, Valerie, Dunn, David, Fairley, Ian, Fox, Ashini, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hembrom, Rajesh, Hill, Teresa, Johnson, Margaret, Jose, Sophie, Kegg, Stephen, Leen, Clifford, Mital, Dushyant, Nelson, Mark, Okhai, Hajra, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Price, Ashley, Post, Frank, Pritchard, Jillian, Sabin, Caroline, Schwenk, Achim, Tariq, Anjum, Trevelion, Roy, Ustianowski, Andy, Walsh, John, Tariq, Shema, Burns, Fiona, Gilleece, Yvonne, Dhairyawan, Rageshri, Peters, Helen, Thorne, Claire, and Sabin, Caroline A

Published
2021
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3. A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

Author

Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Babiker, Abdel, Chadwick, David R, Churchill, Duncan, Dunn, David, Gilson, Richard, Gompels, Mark, Hay, Phillip, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Martin, Fabiola, Mital, Dushyant, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Scwenk, Achim, Tariq, Anjum, Trevelion, Roy, Ustianowski, Andy, Walsh, John, Jose, Sophie, Delpech, Valerie, Howarth, Alison, Burns, Fiona, Hill, Teresa, Porter, Kholoud, and Sabin, Caroline A

Published
2018
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5. A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial

Author

Iwuji, Collins C., Churchill, Duncan, Bremner, Stephen, Perry, Nicky, To, Ye, Lambert, Debbie, Bruce, Chloe, Waters, Laura, Orkin, Chloe, and Geretti, Anna Maria

Published
2020
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6. BHIVA guidelines on antiretroviral treatment for adults living with HIV‐1 2022

Author

Waters, Laura, primary, Winston, Alan, additional, Reeves, Iain, additional, Boffito, Marta, additional, Churchill, Duncan, additional, Cromarty, Ben, additional, Dunn, David, additional, Fink, Douglas, additional, Fidler, Sarah, additional, Foster, Caroline, additional, Fox, Julie, additional, Gupta, Ravi, additional, Hilton, Andy, additional, Khoo, Saye, additional, Leen, Clifford, additional, Mackie, Nicola, additional, Naous, Nadia, additional, Ogbonmwan, Daisy, additional, Orkin, Chloe, additional, Panton, Linda, additional, Post, Frank, additional, Pozniak, Anton, additional, Sabin, Caroline, additional, and Walsh, John, additional

Published
2022
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8. Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen

Author

De Luca, Andrea, Flandre, Philippe, Dunn, David, Zazzi, Maurizio, Wensing, Annemarie, Santoro, Maria Mercedes, Günthard, Huldrych F., Wittkop, Linda, Kordossis, Theodoros, Garcia, Federico, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, De Wit, Stéphane, Brockmeyer, Norbert H., Imaz, Arkaitz, Mussini, Cristina, Obel, Niels, Perno, Carlo Federico, Roca, Bernardino, Reiss, Peter, Schülter, Eugen, Torti, Carlo, van Sighem, Ard, Zangerle, Robert, Descamps, Diane, De Luca, Andrea, Flandre, Philippe, Descamps, Diane, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, Dunn, David, De Wit, Stéphane, Brockmeyer, Norbert H., Garcia, Federico, Imaz, Arkaitz, Kordossis, Theodoros, Mussini, Cristina, Obel, Niels, Roca, Bernardino, Torti, Carlo, van Sighem, Ard, Wensing, Annemarie, Zangerle, Robert, Wittkop, Linda, Reiss, Peter, Ceccherini-Silberstein, Francesca, Santoro, Maria Mercedes, Perno, Carlo Federico, Günthard, Huldrych, Schülter, Eugen, Zazzi, Maurizio, Wittkop, Linda, Descamps, Diane, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, del Amo, Julia, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella dʼArminio, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, Jose M., Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, de Wit, Stéphane, Miró, Jose M., Costagliola, Dominique, dʼArminio-Monforte, Antonella, Castagna, Antonella, del Amo, Julia, Mocroft, Amanda, Raben, Dorthe, Chêne, Geneviève, Judd, Ali, Conejo, Pablo Rojo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Wittkop, Linda, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Raben, Dorthe, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Bucher, Heiner, Cozzi-Lepri, Alessandro, Dabis, François, Monforte, Antonella dʼArminio, Davies, Mary-Anne, del Amo, Julia, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Judd, Ali, Kirk, Ole, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Meyer, Laurence, Miró, Jose M., Mocroft, Amanda, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Thorne, Claire, Torti, Carlo, van der Valk, Marc, Wittkop, Linda, Wyss, Natasha, Aubert, V., Battegay, M., Bernasconi, E., Böni, J., Bucher, H. C., Burton-Jeangros, C., Calmy, A., Cavassini, M., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C. A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, B. Martinez, Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schüpbach, J., Speck, R., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., and Yerly, S.

Published
2016
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10. A tale of two countries: all‐cause mortality among people living with HIV and receiving combination antiretroviral therapy in the UK and Canada

Author

Patterson, S, Jose, S, Samji, H, Cescon, A, Ding, E, Zhu, J, Anderson, J, Burchell, AN, Cooper, C, Hill, T, Hull, M, Klein, MB, Loutfy, M, Martin, F, Machouf, N, Montaner, JSG, Nelson, M, Raboud, J, Rourke, SB, Tsoukas, C, Hogg, RS, Sabin, C, Kelly, Deborah, Sanche, Stephen, Wong, Alexander, Antoniou, Tony, Bayoumi, Ahmed, Nosyk, Bohdan, Cotterchio, Michelle, Goldsmith, Charlie, Guillemi, Silvia, Richard Harrigan, P., Harris, Marianne, Hosein, Sean, Johnston, Sharon, Liddy, Clare, Lima, Viviane, Moore, David, Palmer, Alexis, Phillips, Peter, Rachlis, Anita, Smieja, Marek, Trottier, Benoit, Wainberg, Mark, Walmsley, Sharon, Archibald, Chris, Clement, Ken, Doolittle‐Romas, Monique, Edmiston, Laurie, Huskins, Brian, Lawless, Jerry, Lee, Douglas, Masching, Renee, Tattle, Stephen, Zahirieh, Alireza, Allen, Claire, Calvez, Stryker, Colley, Guillaume, Chia, Jason, Corsi, Daniel, Gilbert, Louise, Gataric, Nada, Leslie, Alia, Light, Lucia, Mackie, David, Pexos, Costa, Shurgold, Susan, Szadkowski, Leah, Wong, John, Yip, Benita, Younger, Jaime, Ainsworth, Jonathan, Allan, Sris, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Dunn, David, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Thornton, Alicia, Glabay, Adam, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Churchill, Duncan, Everett, Rhiannon, Asboe, David, Mandalia, Sundhiya, Korat, Hardik, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Brima, Nataliya, Williams, Ian, Youle, Mike, Lampe, Fiona, Smith, Colette, Tsintas, Rob, Chaloner, Clinton, Hutchinson, Samantha, Huntington, Susie, Mackie, Nicky, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Lynch, Janet, Hand, James, de Souza, Carl, Munshi, Sajid, Miller, Sheila, Wood, Chris, Wilson, Alan, Morris, Sheila, Allan, Sue, Memon, Khurram, Lewszuk, Adam, Cope, Emma, Gibson, Jane, Main, Paul, Dhillon, Mandip, Russell‐Sharpe, Sarah, Harte, Andrew, Clay, Stephen, Spencer, Hazel, Jones, Ron, Cumming, Shirley, Atkinson, Claire, and Trevelion, Roy

Published
2017
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11. An effective strategy to diagnose HIV infection: findings from a national audit of HIV partner notification outcomes in sexual health and infectious disease clinics in the UK

Author

Rayment, Michael, Curtis, Hilary, Carne, Chris, McClean, Hugo, Bell, Gill, Estcourt, Claudia, Roberts, Jonathon, Wilkins, Ed, Estreich, Steven, Morris, Georgina, Phattey, Jara, Sullivan, Ann K, Apea, Vanessa, Menon-Johansson, Anatole, Gupta, Meena, Anderson, Liz, Price, Huw, Williams, Andy, Tayal, Sarup, Quah, Say, Saxon, Cara, Wildman, Gill, Cunningham, Ciara, Hughes, Amelia, DeBurgh-Thomas, Andrew, Ostrich, Steven, Pammi, Manjula, Sethupathi, Meena, Scofield, Sara, Bhaduri, Sumit, Farazmand, Maneh, Street, Emma, Brady, Sophie, Daniels, David, Wiggins, Helen, Buitendam, Erna, Saunders, John, Ward, Helen, Hardie, Jamie, Freedman, Andrew, Angus, Brian, Asboe, David, Brough, Garry, Burns, Fiona, Chadwick, David, Churchill, Duncan, Delpech, Valerie, Doerholt, Katja, Gillette, Yvonne, Molloy, Aoife, Okoli, Chinyere, Ong, Ed, Rodger, Alison, Sabin, Caroline, Musonda, Julie, and Raffe, Sonia

Published
2017
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12. Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV

Author

Stirrup, Oliver T, Sabin, Caroline A, Phillips, Andrew N, Williams, Ian, Churchill, Duncan, Tostevin, Anna, Hill, Teresa, and Dunn, David T

Subjects
NNRTI, viral suppression, drug resistance, NRTI, antiretroviral therapy, viral failure, HIV, ART, Original Research
Abstract

Objectives The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral therapy and risk of virological failure (VF) with or without drug resistance. Methods We conducted an analysis of UK Collaborative HIV Cohort data linked to the UK HIV Drug Resistance Database. Inclusion criteria were viral sequence showing no resistance prior to initiation of first-line efavirenz + tenofovir disoproxil fumarate + emtricitabine and virological suppression within 6 months. Outcomes of VF (≥200 copies/mL) with or without drug resistance were assessed using a competing risks approach fitted jointly with a model for CD4 cell count recovery. Hazard ratios for each VF outcome were estimated for baseline CD4 cell count and viral load and characteristics of CD4 cell count response using latent variables on a standard normal scale. Results A total of 3640 people were included with 338 VF events; corresponding viral sequences were available in 134 with ≥1 resistance mutation in 36. VF with resistance was associated with lower baseline CD4 (0.30, 0.09–0.62), lower CD4 recovery (0.04, 0.00–0.17) and higher CD4 variability (4.40, 1.22–12.68). A different pattern of associations was observed for VF without resistance, but the strength of these results was less consistent across sensitivity analyses. Cumulative incidence of VF with resistance was estimated to be

Published
2019

15. Association of pregnancy with engagement in HIV care among women with HIV in the UK: a cohort study

Author

Okhai, Hajra, primary, Tariq, Shema, additional, Burns, Fiona, additional, Gilleece, Yvonne, additional, Dhairyawan, Rageshri, additional, Hill, Teresa, additional, Peters, Helen, additional, Thorne, Claire, additional, Sabin, Caroline A, additional, Ainsworth, Jonathan, additional, Allan, Sris, additional, Anderson, Jane, additional, Apoola, Ade, additional, Chadwick, David, additional, Churchill, Duncan, additional, Delpech, Valerie, additional, Dunn, David, additional, Fairley, Ian, additional, Fox, Ashini, additional, Gilson, Richard, additional, Gompels, Mark, additional, Hay, Phillip, additional, Hembrom, Rajesh, additional, Johnson, Margaret, additional, Jose, Sophie, additional, Kegg, Stephen, additional, Leen, Clifford, additional, Mital, Dushyant, additional, Nelson, Mark, additional, Okhai, Hajra, additional, Orkin, Chloe, additional, Palfreeman, Adrian, additional, Phillips, Andrew, additional, Pillay, Deenan, additional, Price, Ashley, additional, Post, Frank, additional, Pritchard, Jillian, additional, Sabin, Caroline, additional, Schwenk, Achim, additional, Tariq, Anjum, additional, Trevelion, Roy, additional, Ustianowski, Andy, additional, and Walsh, John, additional

Published
2021
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16. Additional file 1 of A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial

Author

Iwuji, Collins C., Churchill, Duncan, Bremner, Stephen, Perry, Nicky, To, Ye, Lambert, Debbie, Bruce, Chloe, Waters, Laura, Orkin, Chloe, and Geretti, Anna Maria

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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19. Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

Author

Jose, S., Quinn, K., Dunn, D., Cox, A., Sabin, C., Fidler, S., Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Johnson, Margaret, Kegg, Stephen, Leen, C., Martin, Fabiola, Nelson, Mark, Palfreeman, Adrian, Post, F., Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Hill, Teresa, Jose, Sophie, Phillips, Andrew, Sabin, Caroline, Thornton, Alicia, Dunn, David, Glabay, Adam, Fisher, M., Perry, N., Tilbury, S., Youssef, E., Churchill, D., Gazzard, B., Nelson, M., Everett, R., Asboe, D., Mandalia, S., Korat, H., Taylor, C., Gleisner, Z., Ibrahim, F., Campbell, L., Gilson, R., Brima, N., Williams, I., Johnson, M., Youle, M., Lampe, F., Smith, C., Tsintas, R., Chaloner, C., Hutchinson, S., Phillips, A., Hill, T., Thornton, A., Huntington, S., Walsh, J., Mackie, N., Winston, A., Weber, J., Ramzan, F., Carder, M., Orkin, C., Lynch, J., Hand, J., de Souza, C., Anderson, J., Munshi, S., Ainsworth, J., Schwenk, A., Miller, S., Wood, C., Wilson, A., Morris, S., Gompels, M., Allan, S., Palfreeman, A., Memon, K., Lewszuk, A., Chadwick, D., Cope, E., Gibson, J., Kegg, S., Main, P., Mitchell, Hunter, Hay, P., Dhillon, M., Martin, F., Russell-Sharpe, S., Harte, A., Clay, S., Tariq, A., Spencer, H., Jones, R., Pritchard, J., Cumming, S., Atkinson, C., Delpech, Valerie, Sachikony, M., Aitken, Celia, Asboe, David, Pozniak, Anton, Cane, Patricia, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Tostevin, Anna, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mbisa, Tamyo, Mackie, Nicola, Moses, Samuel, Orkin, Chloe, Nastouli, Eleni, Pillay, Deenan, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Williams, Ian, Zhang, Hongyi, Greatorex, Jane, O'Shea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Pereira, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley-Stewart, Amanda, and Medical Research Council (MRC)

Subjects
0301 basic medicine, Male, HAART, HIV Infections, Treatment failure, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antiretroviral Therapy, Highly Active, Pharmacology (medical), 030212 general & internal medicine, Treatment Failure, virological failure, Health Policy, UK CHIC and UK HDRD Steering Committees, Virological failure, 3. Good health, Antiretroviral therapy, Patient benefit, Infectious Diseases, Female, medicine.symptom, Life Sciences & Biomedicine, Viral load, Cart, medicine.medical_specialty, Anti-HIV Agents, Short Communication, antiretroviral therapy, CD4 count, Asymptomatic, 03 medical and health sciences, HIV-INFECTION, Virology, Internal medicine, Drug Resistance, Viral, medicine, Humans, Science & Technology, business.industry, HIV resistance, 1103 Clinical Sciences, 030112 virology, CD4 Lymphocyte Count, Immunology, Mutation, business
Abstract

Objectives No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development. Methods In a large cohort of HIV-positive individuals, we investigated the emergence of new resistance mutations upon virological treatment failure according to the CD4 count at the initiation of cART. Results Of 7918 included individuals, 6514 (82.3%), 996 (12.6%) and 408 (5.2%) started cART with a CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Virological rebound occurred while on cART in 488 (7.5%), 46 (4.6%) and 30 (7.4%) with a baseline CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Only four (13.0%) individuals with a baseline CD4 count > 350 cells/μL in receipt of a resistance test at viral load rebound were found to have developed new resistance mutations. This compared to 107 (41.2%) of those with virological failure who had initiated cART with a CD4 count

Published
2015

20. Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Author

Mehta, Puja, Holder, Susan, Fisher, Benjamin, Vincent, Tonia, Nadesalingam, Kavitha, Maciver, Helen, Shingler, Wendy, Bakshi, Jyoti, Hassan, Sadon, D'Cruz, David, Chan, Antoni, Litwic, Anna E., McCrae, Fiona, Seth, Rakhi, Nandagudi, Anupama, Jury, Elizabeth, Isenberg, David, Karjigi, Uma, Paul, Anupam, Rees, Frances, O'Dowd, Emma, Kinnear, William, Johnson, Simon, Lanyon, Peter, Stevens, Richard, Narayan, Nehal, Marguerie, Christopher, Robinson, Helena, Ffolkes, Lorrette, Worsnop, Fiona, Ostlere, Lucy, Kiely, Patrick, Dharmapalaiah, Chethana, Hassan, Nada, Bharadwaj, Anurag, Skibinska, Malgorzata, Gendi, Nagui, Davies, Emma J., Akil, Mohammed, Kilding, Rachael, Ramachandran Nair, Jagdish, Walsh, Maeve, Farrar, Wendy, Thompson, Robert N., Borukhson, Liubov, McFadyen, Charles, Singh, Deepwant, Rajagopal, Vivek, Chan, Angela Marie L., Wearn Koh, Li, Christie, Jennifer D., Croot, Lorraine, Gayed, Mary, Disney, Benjamin, Singhal, Saket, Grindulis, Karl, Reynolds, Timothy D., Conway, Katie, Williams, Debbie, Quin, John, Dean, Gillian, Churchill, Duncan, Walker-Bone, Karen E., Goff, Iain, Reynolds, Gary, Grove, Matthew, Patel, Priya, Lazarus, Mark N., Roncaroli, Frederico, Gabriel, Carolyn, Kinderlerer, Anne R., Nikiphorou, Elena, Hall, Frances C., Bruce, Ellen, Gray, Leanne, Krutikov, Maria, Wig, Surabhi, Bruce, Ian, D'Agostino, Maria A., Wakefield, Richard, Berner Hammer, Hilde, Vittecoq, Olivier, Galeazzi, Mauro, Balint, Peter, Filippucci, Emilio, Moller, Ingrid, Iagnocco, Annamaria, Naredo, Esperanza, Ostergaard, Mikkel, Gaillez, Corine, Kerselaers, Wendy, Van Holder, Karina, Le Bars, Manuela, Stone, Millicent A., Williams, Francis, Wolber, Lisa, Karppinen, Jaro, Maatta, Juhani, Thompson, Ben, Atchia, Ismael, Lorenzi, Alice, Raftery, Graham, Platt, Phil, Platt, Philip N., Pratt, Arthur, Turmezei, Thomas D., Treece, Graham M., Gee, Andrew H., Poole, Kenneth E., Chandratre, Priyanka N., Roddy, Edward, Clarson, Lorna, Richardson, Jane, Hider, Samantha, Mallen, Christian, Lieberman, Abigail, Prouse, Peter J., Mahendran, Prini, Samarawickrama, Amanda, Ottery, Faith D., Yood, Robert, Wolfson, Marsha, Ang, Andrea, Riches, Philip, Thomson, Janet, Nuki, George, Humphreys, Jennifer, Verstappen, Suzanne M., Chipping, Jacqueline, Hyrich, Kimme, Marshall, Tarnya, Symmons, Deborah P., Roy, Matthew, Kirwan, John R., Marshall, Robert W., Matcham, Faith, Scott, Ian C., Rayner, Lauren, Hotopf, Matthew, Kingsley, Gabrielle H., Scott, David L., Steer, Sophia, Ma, Margaret H., Dahanayake, Chanaka, Kingsley, Gabrielle, Cope, Andrew, Wernham, Aaron, Ward, Lorna, Carruthers, David, Deeming, Alison, Buckley, Christopher, Raza, Karim, De Pablo, Paola, Carpenter, Lewis, Jayakumar, Keeranur, Solymossy, Csilla, Dixey, Josh, Young, Adam, Singh, Animesh, Penn, Henry, Ellerby, Nicholas, Mattey, Derek L., Packham, Jonathan, Dawes, Peter, Hider, Samantha L., Ng, Nora, Humby, Frances, Bombardieri, Michele, Kelly, Stephen, Di Cicco, Maria, Dadoun, Sabrina, Hands, Rebecca, Rocher, Vidalba, Kidd, Bruce, Pyne, Dev, Pitzalis, Costantino, Poore, Sophie, Hutchinson, David, Low, Audrey, Lunt, Mark, Mercer, Louise, Galloway, James, Davies, Rebecca, Watson, Kath, Dixon, Will, Symmons, Deborah, Watson, Kath D., Dixon, William G., Hyrich, Kimme L., Malik, Saadia P., Kelly, Clive, Hamilton, Jennifer, Heycock, Carol, Saravanan, Vadivelu, Rynne, Martin, Harris, Helen E., Tweedie, Fiona, Skaparis, Yiannis, White, Marie, Scott, Nicola, Samson, Kay, Mercieca, Cecilia, Clarke, Shane, Warner, Alexander J., Verstappen, Suzanne, Chan, Esther, Woodhead, Felix A., Nisar, Mohamed, Arthanari, S., Dawson, Julie, Sathi, Nav, Ahmad, Yasmeen, Koduri, Gouri, Cumming, Jo, Stannett, Peter, Hull, Richard, Metsios, George, Stavropoulos Kalinoglou, Antonios, Veldhuijzen van Zanten, Jet J., Nightingale, Peter, Koutedakis, Yiannis, Kitas, George D., Williams, Peter, Walsh, David, Perry, Elizabeth, de-Soyza, Anthony, Moullaali, Thomas, Eggleton, Paul, Stavropoulos-Kalinoglou, Antonios, Sandoo, Aamer, de Pablo, Paola, Maggs, Fiona, Faizal, Abdul, Pugh, Mark, Jobanputra, Paresh, Kehoe, Oksana, Cartwright, Alison, Askari, Ayman, El Haj, Alicia, Middleton, Jim, Aynsley, Sarah, Hardy, Jacob, Veale, Douglas, Fearon, Ursula, Wilson, Gerry, Muthana, Munitta, Fossati, G., Healy, L., Nesbitt, A., Becerra, Elena, Leandro, Maria J., De La Torre, Inmaculada, Cambridge, Geraldine, Nelson, P. N., Roden, D., Shaw, M., Davari Ejtehadi, Hora, Nevill, A., Freimanis, G., Hooley, P., Bowman, S., Alavi, A., Axford, J., Veitch, A. M., Tugnet, N., Rylance, P. B., Hawtree, Sarah, Mark Wilkinson, J., Wilson, Anthony G., Woon Kam, Ngar, Filter, Andrew, Croft, Adam P., Naylor, Amy, Zimmermann, Birgit, Hardie, Debbie, Desanti, Guillaume, Jaurez, Maria, Muller-Ladner, Ulf, Filer, Andrew, Neumann, Elena, Movahedi, Mohammad, Ray, David W., Burmester, Gerd R., Matucci-Cerinic, Marco, Navarro-Blasco, Francisco, Kary, Sonja, Unnebrink, Kristina, Kupper, Hartmut, Mukherjee, Sandeep, Cornell, Patricia, Richards, Selwyn, Rahmeh, Fouz, Thompson, Paul W., Westlake, Sarah L., Javaid, Muhammad K., Batra, Rajbir, Chana, Jasroop, Round, Gemma, Judge, Andrew, Taylor, Peter, Patel, Sanjeev, Cooper, Cyrus, Ravindran, Vinod, Bingham, Clifton O., Weinblatt, Michael E., Mendelsohn, Alan, Kim, Lilianne, Mack, Michael, Lu, Jiandong, Baker, Daniel, Westhovens, Rene, Hewitt, Jamie, Han, Chenglong, Keystone, Edward C., Fleischmann, Roy, Smolen, Josef, Emery, Paul, Genovese, Mark, Doyle, Mittie, Hsia, Elizabeth C., Hart, Jennifer C., Harland, Dave, Gibbons, Carl, Pang, Hok, Huertas, Catherine, Diamantopoulos, Alex, Dejonckheere, Fred, Clowse, M., Wolf, D., Stach, C., Kosutic, G., Williams, S., Terpstra, I., Mahadevan, U., Ferraccioli, G., Samborski, W., Berenbaum, F., Davies, O., Koetse, W., Bennett, B., Burkhardt, H., Luijtens, K., van der Heijde, Desiree, Mariette, X., van Vollenhoven, Ronald F., Bykerk, V., de Longueville, M., Arendt, C., Cush, J., Khan, Afsha, Maclaren, Zoe, Dubash, Sayam, Chalam, Venkat C., Sheeran, Tom, Price, Tom, Baskar, Sangeetha, Mulherin, Diarmuid, Molloy, Cauline, Keay, Fiona, Heritage, Caroline, Douglas, Barbara, Schiff, Michael H., Khanna, Dinesh, Furst, Daniel E., Maldonado, Michael A., Li, Wanying, Sasso, Eric H., Emerling, Daniel, Cavet, Guy, Ford, Kerri, Mackenzie-Green, Bronwen, Collins, David, Price, Elizabeth, Williamson, Lyn, Golla, Janardhana, Vagadia, Vipul, Morrison, Elaine, Tierney, Ann, Wilson, Hilary, Hunter, John, Reddy, Venkat, Moore, Samantha, Ehrenstein, Michael, Benson, Claire, Wray, Maria, Cairns, Andrew, Wright, Gary, Pendleton, Adrian, McHenry, Michelle, Taggart, Allister, Bell, Aubrey, Bosworth, Ailsa, Cox, Maureen, Johnston, Graeme, Shah, Preeti, O'Brien, Anne, Jones, Peter, Sargeant, Ify, Bukhari, Marwan, Nusslein, Hubert, Alten, Rieke, Lorenz, Hannes M., Boumpas, Dimitrios, Nurmohamed, Michael T., Bensen, William, Peter, Hans-Hartmut, Rainer, Franz, Pavelka, Karel, Chartier, Melanie, Poncet, Coralie, Rauch, Christiane, Lempp, Heidi, Hofmann, Darija, Adu, Aderonke, Congreve, Carron, Dobson, Joanne, Rose, Diana, Simpson, Carol, Wykes, Til, Ibrahim, Fowzia, Schiff, Michael, Nash, Peter, Durez, Patrick, Kaine, Jeffrey, Delaet, Ingrid, Kelly, Sheila, Maldonado, Michael, Patel, Salil, Jones, Graeme, Sebba, Anthony, Lepley, Denise, Devenport, Jenny, Bernasconi, Corrado, Smart, Devi, Mpofu, Chiedzo, Gomez-Reino, Juan J., Verma, Inderjeet, Kaur, Jaspreet, Syngle, Ashit, Krishan, Pawan, Vohra, Kanchan, Kaur, Ladbans, Garg, Nidhi, Chhabara, Monica, Gibson, Kellie, Woodburn, James, Telfer, Scott, Buckley, Felicity, Finckh, Axel, Huizinga, Tom W., Jansen, Jeroen P., Rubbert-Roth, Andrea, Scali, Juan J., Kremer, Joel M., Pitts, Laura, Vernon, Emma, Sharif, Mohammed I., Das, Sudipto, Helliwell, Philip, Sokoll, Katharina, and Vital, Edward M.

Subjects
cardiovascular system
Abstract

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interest

Published
2017

21. Continuation of emtricitabine/lamivudine within combination antiretroviral therapy following detection of the M184V/I HIV‐1 resistance mutation.

Author

Stirrup, OT, Asboe, D, Pozniak, A, Sabin, CA, Gilson, R, Mackie, NE, Tostevin, A, Hill, T, Dunn, DT, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Fraser, Christophe, Geretti, Anna Maria, and Gunson, Rory

Subjects
COMBINATION drug therapy, DRUG resistance, HIV infections, HIV-positive persons, GENETIC mutation, POISSON distribution, TREATMENT effectiveness, PROPORTIONAL hazards models, LAMIVUDINE, EMTRICITABINE, STATISTICAL models, THERAPEUTICS
Abstract

Objectives: The aim of the study was to investigate whether lamivudine (3TC) or emtricitabine (FTC) use following detection of M184V/I is associated with better virological outcomes. Methods: We identified people with viruses harbouring the M184V/I mutation in UK multicentre data sets who had treatment change/initiation within 1 year. We analysed outcomes of viral suppression (< 200 HIV‐1 RNA copies/mL) and appearance of new major drug resistance mutations (DRMs) using Cox and Poisson models, with stratification by new drug regimen (excluding 3TC/FTC) and Bayesian implementation, and estimated the effect of 3TC/FTC adjusted for individual and viral characteristics. Results: We included 2597 people with the M184V/I resistance mutation, of whom 665 (25.6%) were on 3TC and 458 (17.6%) on FTC. We found a negative adjusted association between 3TC/FTC use and viral suppression [hazard ratio (HR) 0.84; 95% credibility interval (CrI) 0.71–0.98]. On subgroup analysis of individual drugs, there was no evidence of an association with viral suppression for 3TC (n = 184; HR 0.94; 95% CrI 0.73–1.15) or FTC (n = 454; HR 0.99; 95% CrI 0.80–1.19) amongst those on tenofovir‐containing regimens, but we estimated a reduced rate of viral suppression for people on 3TC amongst those without tenofovir use (n = 481; HR 0.71; 95% CrI 0.54–0.90). We found no association between 3TC/FTC and detection of any new DRM (overall HR 0.92; 95% CrI 0.64–1.18), but found inconclusive evidence of a lower incidence rate of new DRMs (overall incidence rate ratio 0.69; 95% CrI 0.34–1.11). Conclusions: We did not find evidence that 3TC or FTC use is associated with an increase in viral suppression, but it may reduce the appearance of additional DRMs in people with M184V/I. 3TC was associated with reduced viral suppression amongst people on regimens without tenofovir. [ABSTRACT FROM AUTHOR]

Published
2020
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22. A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

Author

Jose, Sophie, primary, Delpech, Valerie, additional, Howarth, Alison, additional, Burns, Fiona, additional, Hill, Teresa, additional, Porter, Kholoud, additional, Sabin, Caroline A, additional, Ainsworth, Jonathan, additional, Allan, Sris, additional, Anderson, Jane, additional, Babiker, Abdel, additional, Chadwick, David R, additional, Churchill, Duncan, additional, Dunn, David, additional, Gilson, Richard, additional, Gompels, Mark, additional, Hay, Phillip, additional, Johnson, Margaret, additional, Kegg, Stephen, additional, Leen, Clifford, additional, Martin, Fabiola, additional, Mital, Dushyant, additional, Nelson, Mark, additional, Orkin, Chloe, additional, Palfreeman, Adrian, additional, Phillips, Andrew, additional, Pillay, Deenan, additional, Post, Frank, additional, Pritchard, Jillian, additional, Scwenk, Achim, additional, Tariq, Anjum, additional, Trevelion, Roy, additional, Ustianowski, Andy, additional, and Walsh, John, additional

Published
2018
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23. British HIV Association guidelines for the treatment of HIV‐1‐positive adults with antiretroviral therapy 2015

Author

Churchill, Duncan, Waters, Laura, Ahmed, Nadia, Angus, Brian, Boffito, Marta, Bower, Mark, Dunn, David, Edwards, Simon, Emerson, Carol, Fidler, Sarah, Fisher, Martin, Horne, Rob, Khoo, Saye, Leen, Clifford, Mackie, Nicola, Marshall, Neal, Monteiro, Fernando, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Pett, Sarah, Phillips, Andrew, Post, Frank, Pozniak, Anton, Reeves, Iain, Sabin, Caroline, Trevelion, Roy, Walsh, John, Wilkins, Ed, Williams, Ian, Winston, Alan, and Grp, Writing

Subjects
Adult, 0301 basic medicine, medicine.medical_specialty, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Antiretroviral Therapy, Highly Active, Internal medicine, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Reino unido, Reverse-transcriptase inhibitor, business.industry, Health Policy, 030112 virology, Antiretroviral therapy, United Kingdom, Coronary heart disease, Infectious Diseases, Anti-Retroviral Agents, Practice Guidelines as Topic, HIV-1, Non inferiority trial, business, medicine.drug
Published
2016

26. Prevalence of and risk factors for gout in HIV-positive adults: A case-control study.

Author

Nicholson, Prini, Saunsbury, Emma, D'Angelo, Stefania, Churchill, Duncan, and Walker-Bone, Karen

Subjects
DISEASE risk factors
Abstract

Gout is the most common inflammatory arthritis worldwide. Its principal risk factor is hyperuricaemia. While gout has been described in HIV patients and numerous more outdated anti-retroviral therapies (ARTs) have been implicated, there have been few recent studies. Our case-control study investigated the prevalence of and risk factors for gout in an established HIV cohort. Cases were identified from database searches using key search terms, with two age- and gender-matched controls. These were compared for demographic factors, co-morbidities, HIV factors and ART exposure. Forty-five cases with gout were identified (point prevalence 2.2%). All were male and were more likely than controls to be of black African origin. Hypertension was associated with an almost five-fold increased gout risk (OR 4.8, 95% CI 1.8-12.4). No individual drug or ART class was associated with gout in this study but exposure to non-nucleoside reverse transcriptase inhibitors had a significantly protective effect against the risk of gout (OR 0.3, 95% CI 0.1-0.9). Our data suggest that gout is common in HIV patients and that the traditional risk factors, especially hypertension, play a key role. Gout and hyperuricaemia should be regarded as a biomarker of cardiovascular disease in HIV patients as they are in the general population. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis

Author

Medicina i Cirurgia, Universitat Rovira i Virgili, Collaboration Observ HIV Epidemio, UK Collaborative HIV Cohort Study, Canadian Observational Cohort Coll, Antiretroviral Therapy Cohort Coll, Russell-Sharp, Sarah, Douglas, Sarah, Martin, Fabiola, Dhillon, Mandip, Hay, Phillip, Sachikonye, Memory, Hunter, Dr, Mitchell, Dr, Main, Paul, Kegg, Stephen, Lewszuk, Adam, Bojanowski, Josef, Fox, Lynn, Moore, Anne, Palfreeman, Adrian, Allan, Sue, Gompels, Mark, Morris, Sheila, Wilson, Alan, Leen, Clifford, Carder, Mark, Ramzan, Farhan, Weber, Jonathan, Winston, Alan, Mackie, Nicky, Walsh, John, Thornton, Alicia, Sabin, Caroline, Phillips, Andrew, Jose, Sophie, Huntington, Susie, Hill, Teresa, Chaloner, Clinton, Smith, Colette, Lampe, Fiona, Youle, Mike, Johnson, Margaret, Wood, Chris, Miller, Sheila, Schwenk, Achim, Ainsworth, Jonathan, Williams, Ian, Brima, Nataliya, Gilson, Richard, Gibson, Jane, Gibney, Marie, Cope, Emma, Baillie, Kirsty, Chadwick, David, Glabay, Adam, Dunn, David, Babiker, Abdel, Campbell, Lucy, Ibrahim, Fowzia, Gleisner, Zachary, Taylor, Chris, Korat, Hardik, Post, Frank, Awosika, Damilola, Munshi, Sajid, Anderson, Jane, Mandalia, Sundhiya, Asboe, David, Waxman, Matthew, Nelson, Mark, Gazzard, Brian, Churchill, Duncan, Youssef, Elaney, Tilbury, Stuart, Perry, Nicky, Fisher, Martin, de Souza, Carl, Hand, James, Lynch, Janet, Garrett, Nigel, Orkin, Chloe, Pillay, Deenan, Delpech, Valerie, Trickey, Adam, Ingle, Suzanne, May, Margaret, Sterne, Jonathan, Zangerle, Robert, Williams, M, Medicina i Cirurgia, Universitat Rovira i Virgili, Collaboration Observ HIV Epidemio, UK Collaborative HIV Cohort Study, Canadian Observational Cohort Coll, Antiretroviral Therapy Cohort Coll, Russell-Sharp, Sarah, Douglas, Sarah, Martin, Fabiola, Dhillon, Mandip, Hay, Phillip, Sachikonye, Memory, Hunter, Dr, Mitchell, Dr, Main, Paul, Kegg, Stephen, Lewszuk, Adam, Bojanowski, Josef, Fox, Lynn, Moore, Anne, Palfreeman, Adrian, Allan, Sue, Gompels, Mark, Morris, Sheila, Wilson, Alan, Leen, Clifford, Carder, Mark, Ramzan, Farhan, Weber, Jonathan, Winston, Alan, Mackie, Nicky, Walsh, John, Thornton, Alicia, Sabin, Caroline, Phillips, Andrew, Jose, Sophie, Huntington, Susie, Hill, Teresa, Chaloner, Clinton, Smith, Colette, Lampe, Fiona, Youle, Mike, Johnson, Margaret, Wood, Chris, Miller, Sheila, Schwenk, Achim, Ainsworth, Jonathan, Williams, Ian, Brima, Nataliya, Gilson, Richard, Gibson, Jane, Gibney, Marie, Cope, Emma, Baillie, Kirsty, Chadwick, David, Glabay, Adam, Dunn, David, Babiker, Abdel, Campbell, Lucy, Ibrahim, Fowzia, Gleisner, Zachary, Taylor, Chris, Korat, Hardik, Post, Frank, Awosika, Damilola, Munshi, Sajid, Anderson, Jane, Mandalia, Sundhiya, Asboe, David, Waxman, Matthew, Nelson, Mark, Gazzard, Brian, Churchill, Duncan, Youssef, Elaney, Tilbury, Stuart, Perry, Nicky, Fisher, Martin, de Souza, Carl, Hand, James, Lynch, Janet, Garrett, Nigel, Orkin, Chloe, Pillay, Deenan, Delpech, Valerie, Trickey, Adam, Ingle, Suzanne, May, Margaret, Sterne, Jonathan, Zangerle, Robert, and Williams, M

Abstract

To estimate prognosis by viral subtype in HIV-1-infected individuals from start of antiretroviral therapy (ART) and after viral failure.Collaborative analysis of data from eight European and three Canadian cohorts.Adults (N>20?000) who started triple ART between 1996 and 2012 and had data on viral subtype were followed for mortality. We estimated crude and adjusted (for age, sex, regimen, CD4 cell count, and AIDS at baseline, period of starting ART, stratified by cohort, region of origin and risk group) mortality hazard ratios (MHR) by subtype. We estimated MHR subsequent to viral failure defined as two HIV-RNA measurements greater than 500 copies/ml after achieving viral suppression.The most prevalent subtypes were B (15?419; 74%), C (2091; 10%), CRF02AG (1057; 5%), A (873; 4%), CRF01AE (506; 2.4%), G (359; 1.7%), and D (232; 1.1%). Subtypes were strongly patterned by region of origin and risk group. During 104?649 person-years of observation, 1172/20?784 patients died. Compared with subtype B, mortality was higher for subtype A, but similar for all other subtypes. MHR for A versus B were 1.13 (95% confidence interval 0.85,1.50) when stratified by cohort, increased to 1.78 (1.27,2.51) on stratification by region and risk, and attenuated to 1.59 (1.14,2.23) on adjustment for covariates. MHR for A versus B was 2.65 (1.64,4.28) and 0.95 (0.57,1.57) for patients who started ART with CD4 cell count below, or more than, 100 cells/?l, respectively. There was no difference in mortality between subtypes A, B and C after viral failure.Patients with subtype A had worse prognosis, an observation which may be confounded by socio-demographic factors.

Published
2016

28. Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis

Author

May, Margaret T., Gill, Michael J., Wittkop, Linda, Klein, Marina, Sabin, Caroline, Harrigan, P. Richard, Dunn, David, Vehreschild, Jorg Janne, Rubio, Rafael, Mocroft, Amanda, Cavassini, Matthias, Reiss, Peter, Monforte, Antonella D'Arminio, Zangerle, Robert, Ingle, Suzanne M., Hill, Teresa, Jose, Sophie, Sterne, Jonathan A. C., Boulle, Andrew, Stephan, Christoph, Miro, Jose M., Chene, Gene-Vieve, Costagliola, Dominique, Dabis, Francois, del Amo, Julia, Van Sighem, Ard, Vehreschild, Jorg, Gill, John, Guest, Jodie, Haerry, David Hans-Ulrich, Hogg, Robert, Justice, Amy, Obel, Niels, Crane, Heidi, Smith, Colette, Saag, Michael, Sterling, Tim, Teira, Ramon, Williams, Matthew, Sterne, Jonathan, May, Margaret, Ingle, Suzanne, Trickey, Adam, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Hay, Phillip, Gompels, Mark, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Mackie, Nicky, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Thornton, Alicia, Huntington, Susie, Glabay, Adam, Garrett, Nigel, Lynch, Janet, Hand, James, de Souza, Carl, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Churchill, Duncan, Waxman, Matthew, Asboe, David, Mandalia, Sundhiya, Munshi, Sajid, Awosika, Damilola, Korat, Hardik, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Baillie, Kirsty, Cope, Emma, Gibney, Marie, Gibson, Jane, Brima, Nataliya, Williams, Ian, Miller, Sheila, Wood, Chris, Youle, Mike, Lampe, Fiona, Chaloner, Clinton, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Wilson, Alan, Morris, Sheila, Allan, Sue, Moore, Anne, Fox, Lynn, Bojanowski, Josef, Lewszuk, Adam, Main, Paul, Mitchell, Dr, Hunter, Dr, Dhillon, Mandip, Martin, Fabiola, Douglas, Sarah, Russell-Sharp, Sarah, May, Margaret T., Gill, Michael J., Wittkop, Linda, Klein, Marina, Sabin, Caroline, Harrigan, P. Richard, Dunn, David, Vehreschild, Jorg Janne, Rubio, Rafael, Mocroft, Amanda, Cavassini, Matthias, Reiss, Peter, Monforte, Antonella D'Arminio, Zangerle, Robert, Ingle, Suzanne M., Hill, Teresa, Jose, Sophie, Sterne, Jonathan A. C., Boulle, Andrew, Stephan, Christoph, Miro, Jose M., Chene, Gene-Vieve, Costagliola, Dominique, Dabis, Francois, del Amo, Julia, Van Sighem, Ard, Vehreschild, Jorg, Gill, John, Guest, Jodie, Haerry, David Hans-Ulrich, Hogg, Robert, Justice, Amy, Obel, Niels, Crane, Heidi, Smith, Colette, Saag, Michael, Sterling, Tim, Teira, Ramon, Williams, Matthew, Sterne, Jonathan, May, Margaret, Ingle, Suzanne, Trickey, Adam, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Hay, Phillip, Gompels, Mark, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Mackie, Nicky, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Thornton, Alicia, Huntington, Susie, Glabay, Adam, Garrett, Nigel, Lynch, Janet, Hand, James, de Souza, Carl, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Churchill, Duncan, Waxman, Matthew, Asboe, David, Mandalia, Sundhiya, Munshi, Sajid, Awosika, Damilola, Korat, Hardik, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Baillie, Kirsty, Cope, Emma, Gibney, Marie, Gibson, Jane, Brima, Nataliya, Williams, Ian, Miller, Sheila, Wood, Chris, Youle, Mike, Lampe, Fiona, Chaloner, Clinton, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Wilson, Alan, Morris, Sheila, Allan, Sue, Moore, Anne, Fox, Lynn, Bojanowski, Josef, Lewszuk, Adam, Main, Paul, Mitchell, Dr, Hunter, Dr, Dhillon, Mandip, Martin, Fabiola, Douglas, Sarah, and Russell-Sharp, Sarah

Abstract

Objectives:To estimate prognosis by viral subtype in HIV-1-infected individuals from start of antiretroviral therapy (ART) and after viral failure.Design:Collaborative analysis of data from eight European and three Canadian cohorts.Methods:Adults (N>20000) who started triple ART between 1996 and 2012 and had data on viral subtype were followed for mortality. We estimated crude and adjusted (for age, sex, regimen, CD4(+) cell count, and AIDS at baseline, period of starting ART, stratified by cohort, region of origin and risk group) mortality hazard ratios (MHR) by subtype. We estimated MHR subsequent to viral failure defined as two HIV-RNA measurements greater than 500 copies/ml after achieving viral suppression.Results:The most prevalent subtypes were B (15419; 74%), C (2091; 10%), CRF02AG (1057; 5%), A (873; 4%), CRF01AE (506; 2.4%), G (359; 1.7%), and D (232; 1.1%). Subtypes were strongly patterned by region of origin and risk group. During 104649 person-years of observation, 1172/20784 patients died. Compared with subtype B, mortality was higher for subtype A, but similar for all other subtypes. MHR for A versus B were 1.13 (95% confidence interval 0.85,1.50) when stratified by cohort, increased to 1.78 (1.27,2.51) on stratification by region and risk, and attenuated to 1.59 (1.14,2.23) on adjustment for covariates. MHR for A versus B was 2.65 (1.64,4.28) and 0.95 (0.57,1.57) for patients who started ART with CD4(+) cell count below, or more than, 100 cells/l, respectively. There was no difference in mortality between subtypes A, B and C after viral failure.Conclusion:Patients with subtype A had worse prognosis, an observation which may be confounded by socio-demographic factors. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

Published
2016

29. Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIRaben-1 subtype B and non-subtype B receiving a salvage regimen

Author

MMB Medische Staf, Infection & Immunity, Master Epidemiologie, De Luca, Andrea, Flandre, Philippe, Dunn, David, Zazzi, Maurizio, Wensing, Annemarie, Santoro, Maria Mercedes, Günthard, Huldrych F., Wittkop, Linda, Kordossis, Theodoros, Garcia, Federico, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, De Wit, Stéphane, Brockmeyer, Norbert H., Imaz, Arkaitz, Mussini, Cristina, Obel, Niels, Perno, Carlo Federico, Roca, Bernardino, Reiss, Peter, Schülter, Eugen, Torti, Carlo, van Sighem, Ard, Zangerle, Robert, Descamps, Diane, Mocroft, Amanda, Kirk, Ole, Sabin, Caroline, Casabona, Jordi, Miró, Jose M., Touloumi, Giota, Garrido, Myriam, Teira, Ramon, Wit, Ferdinand, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, del Amo, Julia, Thorne, Claire, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, d'Arminio Monforte, Antonella, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Tookey, Pat, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Haerry, David, de Wit, Stéphane, Costagliola, Dominique, Raben, Dorthe, Chêne, Geneviève, Ceccherini-Silberstein, Francesca, Günthard, Huldrych, Judd, Ali, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Davies, Mary Anne, Dorrucci, Maria, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, van der Valk, Marc, Wyss, Natasha, Aubert, V., Battegay, M., Bernasconi, E., Böni, J., Burton-Jeangros, C., Calmy, A., Cavassini, M., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C. A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schüpbach, J., Speck, R., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., MMB Medische Staf, Infection & Immunity, Master Epidemiologie, De Luca, Andrea, Flandre, Philippe, Dunn, David, Zazzi, Maurizio, Wensing, Annemarie, Santoro, Maria Mercedes, Günthard, Huldrych F., Wittkop, Linda, Kordossis, Theodoros, Garcia, Federico, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, De Wit, Stéphane, Brockmeyer, Norbert H., Imaz, Arkaitz, Mussini, Cristina, Obel, Niels, Perno, Carlo Federico, Roca, Bernardino, Reiss, Peter, Schülter, Eugen, Torti, Carlo, van Sighem, Ard, Zangerle, Robert, Descamps, Diane, Mocroft, Amanda, Kirk, Ole, Sabin, Caroline, Casabona, Jordi, Miró, Jose M., Touloumi, Giota, Garrido, Myriam, Teira, Ramon, Wit, Ferdinand, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, del Amo, Julia, Thorne, Claire, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, d'Arminio Monforte, Antonella, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Tookey, Pat, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Haerry, David, de Wit, Stéphane, Costagliola, Dominique, Raben, Dorthe, Chêne, Geneviève, Ceccherini-Silberstein, Francesca, Günthard, Huldrych, Judd, Ali, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Davies, Mary Anne, Dorrucci, Maria, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, van der Valk, Marc, Wyss, Natasha, Aubert, V., Battegay, M., Bernasconi, E., Böni, J., Burton-Jeangros, C., Calmy, A., Cavassini, M., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C. A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schüpbach, J., Speck, R., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., and Yerly, S.

Published
2016

33. An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs.

Author

Smit, Erasmus, White, Ellen, Clark, Duncan, Churchill, Duncan, Hongyi Zhang, Collins, Simon, Pillay, Deenan, Sabin, Caroline, Nelson, Mark, Winston, Alan, Jose, Sophie, Tostevin, Anna, Dunn, David T., Zhang, Hongyi, and UK HIV Drug Resistance Database and the UK Collaborative HIV Cohort

Subjects
HIV-positive persons, HIV, TENOFOVIR, MEDICAL care, HIV infections, THERAPEUTICS, ANTI-HIV agents, REVERSE transcriptase inhibitors, DRUG resistance in microorganisms, GENETIC techniques, MULTIVARIATE analysis, GENETIC mutation, RESEARCH funding, HIGHLY active antiretroviral therapy, DIDANOSINE (Drug), STAVUDINE, DEOXYRIBONUCLEOSIDES, SEQUENCE analysis, GENOTYPES
Abstract

Objectives: HIV-1 subtype C might have a greater propensity to develop K65R mutations in patients with virological failure compared with other subtypes. However, the strong association between viral subtype and confounding factors such as exposure groups and ethnicity affects the calculation of this propensity. We exploited the diversity of viral subtypes within the UK to undertake a direct comparative analysis.Patients and methods: We analysed only sequences with major IAS-defined mutations from patients with virological failure. Prevalence of K65R was related to subtype and exposure to the NRTIs that primarily select for this mutation (tenofovir, abacavir, didanosine and stavudine). A multivariate logistic regression model quantified the effect of subtype on the prevalence of K65R, adjusting for previous and current exposure to all four specified drugs.Results: Subtype B patients ( n  =   3410) were mostly MSM (78%) and those with subtype C ( n  =   810) were mostly heterosexual (82%). K65R was detected in 7.8% of subtype B patients compared with 14.2% of subtype C patients. The subtype difference in K65R prevalence was observed irrespective of NRTI exposure and K65R was frequently selected by abacavir, didanosine and stavudine in patients with no previous exposure to tenofovir. Multivariate logistic regression confirmed that K65R was significantly more common in subtype C viruses (adjusted OR = 2.02, 95% CI = 1.55-2.62, P  <   0.001).Conclusions: Patients with subtype C HIV-1 have approximately double the frequency of K65R in our database compared with other subtypes. The exact clinical implications of this finding need to be further elucidated. [ABSTRACT FROM AUTHOR]

Published
2017
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