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2 results on '"Christophersen AK"'

1. [Self-medication with cannabidiol oil in a patient with primary lateral sclerosis].

Author

Karlsborg M, Christophersen AK, Pontoppidan C, and Kampmann JP

Subjects
Adult, Humans, Male, Treatment Outcome, Cannabidiol administration & dosage, Cannabidiol therapeutic use, Motor Neuron Disease drug therapy, Self Medication
Abstract

Many patients with neurological disorders have symptoms which are difficult to treat with conventional medication. In this case report we present a 40-year-old male patient with primary lateral sclerosis who used cannabidiol oil as therapy. We discuss the evidence of the effects of cannabidiol in the treatment of patients with neurological disease, and we raise the question: "Should patients who use illegal cannabis products as self-medication be diagnosed as drug abusers?"

Published
2017

2. An adverse drug event manager facilitates spontaneous reporting of adverse drug reactions.

Author

Vinther S, Klarskov P, Borgeskov H, Darsø P, Christophersen AK, Borck B, Christensen C, Hansen MV, Halladin NM, Christensen MB, Harboe KM, Lund M, and Jimenez-Solem E

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anticoagulants adverse effects, Central Nervous System Stimulants adverse effects, Child, Child, Preschool, Denmark, Dermatology statistics & numerical data, Factor Xa Inhibitors adverse effects, Female, Humans, Infant, Infant, Newborn, Internal Medicine statistics & numerical data, Lisdexamfetamine Dimesylate adverse effects, Male, Middle Aged, Ophthalmology statistics & numerical data, Otolaryngology statistics & numerical data, Product Surveillance, Postmarketing methods, Psychiatric Department, Hospital statistics & numerical data, Retrospective Studies, Rivaroxaban adverse effects, Warfarin adverse effects, Young Adult, Adverse Drug Reaction Reporting Systems statistics & numerical data, Hospital Departments statistics & numerical data, Hospitals statistics & numerical data
Abstract

Introduction: Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assists healthcare professionals in reporting suspected ADRs to the Danish Health Authority. The aim of this retrospective observational study was to quantify and describe ADRs reported via the ADEM in 2014., Methods: All ADR reports handled by the ADEM in 2014 were recorded anonymously and analysed descriptively., Results: A total of 484 ADRs were reported through the ADEM in 2014 (the median number of reports per month was 37; range: 17-78). The majority of the reports came from departments of internal medicine (61%), psychiatry (14%) and dermatology, ophthalmology or otorhinolaryngology (11%). The drugs most frequently reported were lisdexamphetamine (n = 40), rivaroxaban (n = 16) and warfarin (n = 15) (vaccines excluded). In 13 out of 484 reports, the ADR was associated with a fatal outcome., Conclusion: The findings of this study indicate that an ADEM promotes and facilitates spontaneous ADR reporting and helps raise awareness about ADRs, including how and why they should be reported. Hopefully, this will assist national and European spontaneous reporting systems in their work to increase patient safety nationally and abroad., Funding: none., Trial Registration: not relevant. .

Published
2017

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