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Your search keyword '"Cheong, Soon-Keng"' showing total 212 results
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212 results on '"Cheong, Soon-Keng"'

3. Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy

Author

Yuliang Sun, Yilin Lu, Xinze Li, Yanan He, Then Kong Yong, Cheong Soon Keng, Badrul Yahaya, Yanli Liu, and Juntang Lin

Subjects
Cytology, QH573-671
Abstract

Abstract In the process of tumor treatment, systemic drug administration is hindered by biological barriers, leading to the retention of a large number of drug molecules in healthy tissues and causing unavoidable side effects. The precise deployment of drugs at the tumor site is expected to alleviate this phenomenon. Here, we take endostatin and Her2 (+) tumors as examples and develop an intelligent drug with simple “wisdom” by endowing mesenchymal stem cells (MSCs) with an intelligent response program (iMSCEndostatin). It can autonomously perceive and distinguish tumor cells from non-tumor cells, establishing a logical connection between tumor signals and drug release. Enable it to selectively deploy drugs at the tumor site, thereby locking the toxicity of drugs at the tumor site. Unlike traditional aggressive targeting strategies that aim to increase drug concentration at the lesion, intelligent drugs are more inclined to be defensive strategies that prevent the presence of drugs in healthy tissues.

Published
2024
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6. Mesenchymal Stem Cell-Derived Extracellular Vesicles: Progress and Remaining Hurdles in Developing Regulatory Compliant Quality Control Assays

Author

Chua, Jessie Kit Ern, Lim, Jiaxi, Foong, Le Hui, Mok, Chui Yang, Tan, Hsiang Yang, Tung, Xin Yee, Ramasamy, Thamil Selvee, Govindasamy, Vijayendran, Then, Kong-Yong, Das, Anjan Kumar, Cheong, Soon-Keng, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Turksen, Kursad, editor

Published
2022
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7. An Affordable Approach of Mesenchymal Stem Cell Therapy in Treating Perianal Fistula Treatment

Author

Hon, Hui-Nee, Ho, Pei-Yi, Lee, Jing-Wen, Mahmud, Nur Amalin Amni, Munir, Hafsa Binte, Ramasamy, Thamil Selvee, Govindasamy, Vijayendran, Then, Kong-Yong, Das, Anjan Kumar, Cheong, Soon-Keng, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Turksen, Kursad, editor

Published
2022
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15. Current developments and therapeutic potentials of exosomes from induced pluripotent stem cells-derived mesenchymal stem cells

Author

Aldoghachi, Ahmed Faris, primary, Loh, Jit-Kai, additional, Wang, Mong-Lien, additional, Yang, Yi-Ping, additional, Chien, Chian-Shiu, additional, Teh, Hui Xin, additional, Omar, Alfaqih Hussain, additional, Cheong, Soon-Keng, additional, Yeap, Swee Keong, additional, Ho, Wan Yong, additional, and Ong, Alan Han-Kiat, additional

Published
2023
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27. A NARRATIVE REVIEW ON MINDFULNESS PRACTICES IN OPTIMIZING PERFORMANCE AMONG SPORTS INDIVIDUALS

Author

Ramalingam Vinodhkumar, Poh Foong Lee, and Cheong Soon Keng

Subjects
Mindfulness, General Veterinary, Applied psychology, Outcome measures, Affect (psychology), General Biochemistry, Genetics and Molecular Biology, Intervention (counseling), medicine, Anxiety, Narrative review, medicine.symptom, General Agricultural and Biological Sciences, Performance enhancement, Psychology, human activities
Abstract

Mindfulness practice has become an increasingly popular intervention in optimizing athletic performance in sports. Numerous studies have reported on applying mindfulness for improving the performance of various sports such as tennis, table tennis, shooting, cricket, archery, golf, running, hockey, swimming, and cycling. This narrative review addresses different existing mindfulness programs that enhance sports performance, the outcome measures of mindfulness therapy, and identifies the anxiety and depression that affect the performance of sports individuals. To cope with the issues, the efficacy of mindfulness in performance enhancement and future research directions on mindfulness needs attention.

Published
2021

28. ENPP4 and HOXA3 as potential leukaemia stem cell markers in acute myeloid leukaemia.

Author

MOHD AMIN, Amrina, PANNEERSELVAN, Hindhuja, MD NOOR, Sabariah, MOHTARUDDIN, Norhafizah, SATHAR, Jameela, NORBAYA, Wan Siti, OSMAN, Raudhawati, KEE, Lern How, YAAKUB, Wan Hayati MOHD, CHEONG, Soon Keng, and ABDULLAH, Maha

Abstract

Introduction: Acute myeloid leukaemia (AML) is a heterogeneous malignant disease with a high degree of treatment failure using chemotherapy. Leukaemia stem cells (LSCs) are CD34+CD38- early progenitors associated with poor prognosis in AML. A unique LSC phenotype that excludes rare normal haematopoietic stem cells (HSC) is still elusive. This study aimed to determine expression of selected potential LSC markers in normal and leukaemic myeloid cells and correlate prognosis in AML patients. Materials and Methods: Flow cytometry and RT-qPCR measured expressions of ALDH, IL3RA/CD123, CLEC12A/CLL-1/CD371, HOXA3 and ENPP4. Normal cord blood (n=3) and blood monocytes (n=5) represented HSC and mature cells, respectively. Myeloid leukaemia cell lines (THP-1, KG-1a, K562 and HL-60) represented progenitor cells at various stages of maturation. AML samples included chemo-resistant (n=8), early relapse (n=2) and late relapse (n=18). Results: Combining protein/gene expressions, CD34+CD38- was a feature of immature cells seen in cord blood, KG-1a, and K562 but not more mature cells (blood monocytes and HL-60). Normal cells expressed CD371 while mature cells (blood monocytes and HL-60) lacked CD123. ENPP4 was not expressed on normal cells while HOXA3 was expressed only on cord blood and THP-1. In AML, CD123, HOXA3, ENPP4 (but not CD371) were significantly increased in the CD34+CD38- fraction of chemo-resistant patients while ALDH was associated with chemo-resistance. Conclusion: CD34+CD38- presented an immature phenotype and with ALDH were associated with poor prognosis. CD123, HOXA3 and ENPP4 further enriched the LSC population. ENPP4 has not been reported and has the advantage of not being expressed on HSC and normal monocytes. [ABSTRACT FROM AUTHOR]

Published
2023

31. The effects of intravenous infusion of autologous mesenchymal stromal cells in patients with subacute middle cerebral artery infarct: a phase 2 randomized controlled trial on safety, tolerability and efficacy

Author

Law, Zhe Kang, primary, Tan, Hui Jan, additional, Chin, Sze Piaw, additional, Wong, Chee Yin, additional, Wan Yahya, Wan Nur Nafisah, additional, Muda, Ahmad Sobri, additional, Zakaria, Rozman, additional, Ariff, Mohd Izhar, additional, Ismail, Nor Azimah, additional, Cheong, Soon Keng, additional, S Abdul Wahid, S. Fadilah, additional, and Mohamed Ibrahim, Norlinah, additional

Published
2021
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37. Synergistic effects of intracoronary infusion of autologous bone marrow-derived mesenchymal stem cells and revascularization procedure on improvement of cardiac function in patients with severe ischemic cardiomyopathy

Author

Chin, Sze Piaw, primary, Maskon, Oteh, additional, Tan, Chiang Soo, additional, Anderson, John E., additional, Wong, Chee Yin, additional, Hassan, Hamat Hamdi Che, additional, Choor, Chee Ken, additional, Fadilah, S. Abdul Wahid, additional, and Cheong, Soon Keng, additional

Published
2021
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39. Adipose MSCs Suppress MCF7 and MDA-MB-231 Breast Cancer Metastasis and EMT Pathways Leading to Dormancy via Exosomal-miRNAs Following Co-Culture Interaction

Author

Mohd Ali, Norlaily, primary, Yeap, Swee Keong, additional, Ho, Wan Yong, additional, Boo, Lily, additional, Ky, Huynh, additional, Satharasinghe, Dilan Amila, additional, Tan, Sheau Wei, additional, Cheong, Soon Keng, additional, Huang, Hsien Da, additional, Lan, Kuan Chun, additional, Chiew, Men Yee, additional, and Ong, Han Kiat, additional

Published
2020
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40. Mapping a Circular RNA–microRNA–mRNA-Signaling Regulatory Axis that Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells

Author

Rengganaten, Vimalan, primary, Huang, Chiu-Jung, additional, Tsai, Ping-Hsing, additional, Wang, Mong-Lien, additional, Yang, Yi-Ping, additional, Lan, Yuan-Tzu, additional, Fang, Wen-Liang, additional, Soo, Shelly, additional, Ong, Hooi Tin, additional, Cheong, Soon Keng, additional, Choo, Kong Bung, additional, and Chiou, Shih-Hwa, additional

Published
2020
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45. Phenotypic and microRNA characterization of the neglected CD24+ cell population in MCF-7 breast cancer 3-dimensional spheroid culture

Author

Boo, Lily, primary, Yeap, Swee Keong, additional, Ali, Norlaily Mohd, additional, Ho, Wan Yong, additional, Ky, Huynh, additional, Satharasinghe, Dilan Amila, additional, Liew, Woan Charn, additional, Tan, Sheau Wei, additional, Wang, Mong-Lien, additional, Cheong, Soon Keng, additional, and Ong, Han Kiat, additional

Published
2020
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