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1. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author

Aghemo, Alessio, Baiguera, Chiara, Battezzati, Pier Maria, Battistella, Sara, Bavetta, Maria Grazia, Bertoni, Costanza, Boni, Carolina, Brambilla, Paola, Bray, Antonella, Briano, Federica, Carmenini, Enrico, Castelli, Francesco, Cavalletto, Luisa, Cerini, Federica, Chidichimo, Luciana, Colella, Elisa, Cologni, Giuliana, Como, Silvia, Corsini, Romina, Costa, Chiara, Cotugno, Rosa, Cretella, Silvia, De Angelis, Fernando, De Leo, Pasqualina, Perri, Giovanni Di, Falbo, Elisabetta, Ferrigno, Luigina, Fornasiere, Ezio, Francisci, Daniela, Gatti, Pietro, Lampertico, Pietro, Lenci, Ilaria, Licata, Anna, Maida, Ivana, Marzano, Alfredo, Mastroianni, Antonio, Mazzaro, Cesare, Monti, Monica, Nardone, Gerardo, Nicolini, Laura Ambra, Passigato, Nicola, Pasticci, Maria Bruna, Pierotti, Piera, Pinchera, Biagio, Pollicino, Teresa, Porcu, Carmen, Quartini, Giulia, Rancatore, Gabriele, Romeo, Mario, Rumi, Maria Grazia, Saracino, Annalisa, Schioppa, Ornella, Serio, Ilaria, Soffredini, Roberta, Tata, Xhimi, Tizzani, Marco, Tonnini, Matteo, Torti, Carlo, Valenti, Daniela, Zaltron, Serena, Zoncada, Alessia, Kondili, Loreta A., Brancaccio, Giuseppina, Tosti, Maria Elena, Coco, Barbara, Quaranta, Maria Giovanna, Messina, Vincenzo, Ciancio, Alessia, Morisco, Filomena, Cossiga, Valentina, Claar, Ernesto, Rosato, Valerio, Ciarallo, Marianna, Cacciola, Irene, Ponziani, Francesca Romana, Cerrito, Lucia, Coppola, Roberta, Longobardi, Francesco, Biliotti, Elisa, Rianda, Alessia, Barbaro, Francesco, Coppola, Nicola, Stanzione, Maria, Barchiesi, Francesco, Fagiuoli, Stefano, Viganò, Mauro, Massari, Marco, Russo, Francesco Paolo, Ferrarese, Alberto, Laccabue, Diletta, Di Marco, Vito, Blanc, Pierluigi, Marrone, Aldo, Morsica, Giulia, Federico, Alessandro, Ieluzzi, Donatella, Rocco, Alba, Foschi, Francesco Giuseppe, Soria, Alessandro, Chessa, Luchino, Milella, Michele, Rosselli Del Turco, Elena, Madonia, Salvatore, Chemello, Liliana, Gentile, Ivan, Toniutto, Pierluigi, Bassetti, Matteo, Surace, Lorenzo, Baiocchi, Leonardo, Pellicelli, Adriano, De Santis, Adriano, Puoti, Massimo, Degasperi, Elisabetta, Niro, Grazia Anna, Zignego, Anna Linda, Craxi, Antonio, Raimondo, Giovanni, Santantonio, Teresa Antonia, Brunetto, Maurizia Rossana, and Gaeta, Giovanni Battista

Published
2024
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3. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort

Author

Panetta, Valentina, Gaeta, Giovanni Battista, Filomia, Roberto, Coco, Barbara, Monti, Monica, Amoruso, Daniela Caterina, Madonia, Salvatore, Ieluzzi, Donatella, Taliani, Gloria, Badia, Lorenzo, Migliorino, Guglielmo Marco, Giorgini, Alessia, Masarone, Mario, Blanc, Pierluigi, Cossiga, Valentina, De Siena, Martina, Tata, Xhimi, Rumi, Maria Grazia, Chessa, Luchino, Lampertico, Pietro, Ferrari, Carlo, Gentile, Ivan, Parruti, Giustino, Baiocchi, Leonardo, Ciancio, Alessia, Invernizzi, Pietro, Federico, Alessandro, Torti, Carlo, Morsica, Giulia, Andreone, Pietro, Aghemo, Alessio, Popoli, Patrizia, Vella, Stefano, Kondili, Loreta A., Quaranta, Maria Giovanna, Cavalletto, Luisa, Calvaruso, Vincenza, Ferrigno, Luigina, D'Ambrosio, Roberta, Simonelli, Ilaria, Brancaccio, Giuseppina, Raimondo, Giovanni, Brunetto, Maurizia R., Zignego, Anna Linda, Coppola, Carmine, Iannone, Andrea, Biliotti, Elisa, Verucchi, Gabriella, Massari, Marco, Licata, Anna, Barbaro, Francesco, Persico, Marcello, Russo, Francesco Paolo, Morisco, Filomena, Pompili, Maurizio, Viganò, Mauro, Puoti, Massimo, Santantonio, Teresa, Villa, Erica, Craxì, Antonio, and Chemello, Liliana

Published
2023
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4. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Pasulo, Luisa, Coppola, Carmine, Pisano, Federica, Romano, Mariarosaria, Porcu, Carmen, Bottalico, Irene Francesca, Cossiga, Valentina, Tata, Xhimi, Sagnelli, Caterina, Pierotti, Piera, Degasperi, Elisabetta, Rosato, Valerio, Badia, Lorenzo, Ieluzzi, Dontella, Monti, Monica, Bavetta, Maria Grazia, Cavalletto, Luisa, Toniutto, Pierluigi, Fornasiere, Ezio, Colecchia, Antonio, Ferrarese, Alberto, Nardone, Gerardo, Rocco, Alba, Viganò, Mauro, Foschi, Francesco Giuseppe, Conti, Fabio, Morsica, Giulia, Salpietro, Stefania, Torti, Carlo, Costa, Chiara, Federico, Alessandro, Dallio, Marcello, Giorgini, Alessia, Anselmo, Marco, De Leo, Pasqualina, Zaltron, Serena, Cambianica, Anna, Piscaglia, Fabio, Serio, Ilaria, Schivazappa, Simona, Mastroianni, Antonio, Chidichimo, Luciana, Massari, Marco, Mazzaro, Cesare, Marrone, Aldo, D'Amore, Francesca Maria, D'Offizi, Gianpiero, Licata, Anna, Niro, Grazia Anna, Pollicino, Teresa, Aghemo, Alessio, Brancaccio, Giuseppina, Coco, Barbara, Nardi, Alessandra, Quaranta, Maria Giovanna, Tosti, Maria Elena, Ferrigno, Luigina, Cacciola, Irene, Messina, Vincenzo, Chessa, Luchino, Morisco, Filomena, Milella, Michele, Barbaro, Francesco, Ciancio, Alessia, Russo, Francesco Paolo, Coppola, Nicola, Blanc, Pierluigi, Claar, Ernesto, Verucchi, Gabriella, Puoti, Massimo, Zignego, Anna Linda, Chemello, Liliana, Madonia, Salvatore, Fagiuoli, Stefano, Marzano, Alfredo, Ferrari, Carlo, Lampertico, Pietro, Di Marco, Vito, Craxì, Antonio, Santantonio, Teresa Antonia, Raimondo, Giovanni, Brunetto, Maurizia R., Gaeta, Giovanni Battista, and Kondili, Loreta A.

Published
2023
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6. Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort

Author

Mazzaro, Cesare, Bertola, Manuela, Schioppa, Ornella, Benedetti, Antonio, Schiadà, Laura, Cucco, Monica, Giacometti, Andrea, Brescini, Laura, Castelletti, Sefora, Fiorentini, Alessandro, Angarano, Gioacchino, Milella, Michele, Di Leo, Alfredo, Rendina, Maria, D'abramo, Fulvio Salvatore, Lillo, Chiara, Iannone, Andrea, Piazzolla, Mariano, Verucchi, Gabriella, Badia, Lorenzo, Piscaglia, Fabio, Benevento, Francesca, Serio, Ilaria, Castelli, Francesco, Zaltron, Serena, Spinetti, Angiola, Odolini, Silvia, Bruno, Raffaele, Mondelli, Mario, Chessa, Luchino, Loi, Martina, Torti, Carlo, Costa, Chiara, Mazzitelli, Maria, Pisani, Vincenzo, Scaglione, Vincenzo, Trecarichi, Enrico Maria, Zignego, Anna Linda, Monti, Monica, Madia, Francesco, Blanc, Pier Luigi, Attala, Letizia, Pierotti, Piera, Salomoni, Elena, Mariabelli, Elisa, Santantonio, Teresa Antonia, Bruno, Serena Rita, Cela, Ester Marina, Bassetti, Matteo, Mazzarello, Giovanni, Alessandrini, Anna Ida, Di Biagio, Antonio, Nicolini, Laura Ambra, Raimondo, Giovanni, Filomia, Roberto, Aghemo, Alessio, Meli, Rossella, Lazzarin, Adriano, Morsica, Giulia, Salpietro, Stefania, Galli, Massimo, Fracanzani, Anna Ludovica, Fatta, Erika, Lombardi, Rosa, Lampertico, Pietro, Borghi, Marta, D'ambrosio, Roberta, Degasperi, Elisabetta, Puoti, Massimo, Baiguera, Chiara, D'amico, Federico, Vinci, Maria, Rumi, Maria Grazia, Zuin, Massimo, Giorgini, Alessia, Zermiani, Paola, Andreone, Pietro, Caraceni, Paolo, Margotti, Marzia, Guarneri, Valeria, Villa, Erica, Bernabucci, Veronica, Bristot, Laura, Paradiso, Maria Luisa, Migliorino, Guglielmo, Beretta, Ilaria, Gambaro, Alessandra, Lapadula, Giuseppe, Spolti, Anna, Soria, Alessandro, Invernizzi, Pietro, Ciaccio, Antonio, LucÀ, Martina, Malinverno, Federica, Ratti, Laura, Coppola, Carmine, Amoruso, Daniela Caterina, Pisano, Federica, Scarano, Ferdinando, Staiano, Laura, Morisco, Filomena, Cossiga, Valentina, Gentile, Ivan, Buonomo, Antonio Riccardo, Foggia, Maria, Zappulo, Emanuela, Federico, Alessandro, Dallio, Marcello, Coppola, Nicola, Sagnelli, Caterina, Martini, Salvatore, Monari, Caterina, Nardone, Gerardo, Sgamato, Costantino, Chemello, Liliana, Cavalletto, Luisa, Sterrantino, Daniela, Russo, Francesco Paolo, Zanetto, Alberto, Zanaga, Paola, Barbaro, Francesco, Brancaccio, Giuseppina, Craxì, Antonio, Petta, Salvatore, Calvaruso, Vincenza, Crapanzano, Luciano, Madonia, Salvatore, Cannizzaro, Marco, Bruno, Erica Maria, Licata, Anna, Amodeo, Simona, Capitano, Adele Rosaria, Ferrari, Carlo, Laccabue, Diletta, Negri, Elisa, Orlandini, Alessandra, Pesci, Marco, Gulminetti, Roberto, Pagnucco, Layla, Parruti, Giustino, Di Stefano, Paola, Brunetto, Maurizia Rossana, Coco, Barbara, Massari, Marco, Corsini, Romina, Garlassi, Elisa, Andreoni, Massimo, Teti, Elisabetta, Cerva, Carlotta, Baiocchi, Lorenzo, Tata, Xhimi, Grassi, Giuseppe, Gasbarrini, Antonio, Pompili, Maurizio, De Siena, Martina, Taliani, Gloria, Biliotti, Elisa, Spaziante, Martina, Persico, Marcello, Masarone, Mario, Aglitti, Andrea, Calvanese, Gemma, Anselmo, Marco, De Leo, Pasqualina, Marturano, Monica, Saracco, Giorgio Maria, Ciancio, Alessia, Ieluzzi, Donatella, Quaranta, Maria Giovanna, Ferrigno, Luigina, D'Angelo, Franca, Saracino, Annalisa, and Kondili, Loeta A.

Published
2021
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7. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and Delta cohort

Author

Kondili, Loreta A., primary, Brancaccio, Giuseppina, additional, Tosti, Maria Elena, additional, Coco, Barbara, additional, Quaranta, Maria Giovanna, additional, Messina, Vincenzo, additional, Ciancio, Alessia, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, Ciarallo, Marianna, additional, Cacciola, Irene, additional, Ponziani, Francesca Romana, additional, Cerrito, Lucia, additional, Coppola, Roberta, additional, Longobardi, Francesco, additional, Biliotti, Elisa, additional, Rianda, Alessia, additional, Barbaro, Francesco, additional, Coppola, Nicola, additional, Stanzione, Maria, additional, Barchiesi, Francesco, additional, Fagiuoli, Stefano, additional, Viganò, Mauro, additional, Massari, Marco, additional, Russo, Francesco Paolo, additional, Ferrarese, Alberto, additional, Laccabue, Diletta, additional, Marco, Vito Di, additional, Blanc, Pierluigi, additional, Marrone, Aldo, additional, Morsica, Giulia, additional, Federico, Alessandro, additional, Ieluzzi, Donatella, additional, Rocco, Alba, additional, Foschi, Francesco Giuseppe, additional, Soria, Alessandro, additional, Maida, Ivana, additional, Chessa, Luchino, additional, Milella, Michele, additional, Turco, Elena Rosselli del, additional, Madonia, Salvatore, additional, Chemello, Liliana, additional, Gentile, Ivan, additional, Toniutto, Pierluigi, additional, Bassetti, Matteo, additional, Surace, Lorenzo, additional, Baiocchi, Leonardo, additional, Pellicelli, Adriano, additional, De Santis, Adriano, additional, Puoti, Massimo, additional, Degasperi, Elisabetta, additional, Niro, Grazia Anna, additional, Zignego, Anna Linda, additional, Craxi, Antonio, additional, Raimondo, Giovanni, additional, Santantonio, Teresa Antonia, additional, Brunetto, Maurizia Rossana, additional, Gaeta, Giovanni Battista, additional, and Investigators, on behalf of PITER Collaborating, additional

Published
2024
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8. Newly diagnosed hepatocellular carcinoma in patients with advanced hepatitis C treated with DAAs: A prospective population study

Author

Romano, Antonietta, Angeli, Paolo, Piovesan, Sara, Noventa, Franco, Anastassopoulos, Georgios, Chemello, Liliana, Cavalletto, Luisa, Gambato, Martina, Russo, Francesco Paolo, Burra, Patrizia, Vincenzi, Valter, Scotton, Pier Giorgio, Panese, Sandro, Tempesta, Diego, Bertin, Tosca, Carrara, Maurizio, Carlotto, Antonio, Capra, Franco, Carolo, Giada, Scroccaro, Giovanna, and Alberti, Alfredo

Published
2018
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10. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort

Author

Kondili, Loreta A., primary, Quaranta, Maria Giovanna, additional, Cavalletto, Luisa, additional, Calvaruso, Vincenza, additional, Ferrigno, Luigina, additional, D'Ambrosio, Roberta, additional, Simonelli, Ilaria, additional, Brancaccio, Giuseppina, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Zignego, Anna Linda, additional, Coppola, Carmine, additional, Iannone, Andrea, additional, Biliotti, Elisa, additional, Verucchi, Gabriella, additional, Massari, Marco, additional, Licata, Anna, additional, Barbaro, Francesco, additional, Persico, Marcello, additional, Russo, Francesco Paolo, additional, Morisco, Filomena, additional, Pompili, Maurizio, additional, Viganò, Mauro, additional, Puoti, Massimo, additional, Santantonio, Teresa, additional, Villa, Erica, additional, Craxì, Antonio, additional, Chemello, Liliana, additional, Panetta, Valentina, additional, Gaeta, Giovanni Battista, additional, Filomia, Roberto, additional, Coco, Barbara, additional, Monti, Monica, additional, Amoruso, Daniela Caterina, additional, Madonia, Salvatore, additional, Ieluzzi, Donatella, additional, Taliani, Gloria, additional, Badia, Lorenzo, additional, Migliorino, Guglielmo Marco, additional, Giorgini, Alessia, additional, Masarone, Mario, additional, Blanc, Pierluigi, additional, Cossiga, Valentina, additional, De Siena, Martina, additional, Tata, Xhimi, additional, Rumi, Maria Grazia, additional, Chessa, Luchino, additional, Lampertico, Pietro, additional, Ferrari, Carlo, additional, Gentile, Ivan, additional, Parruti, Giustino, additional, Baiocchi, Leonardo, additional, Ciancio, Alessia, additional, Invernizzi, Pietro, additional, Federico, Alessandro, additional, Torti, Carlo, additional, Morsica, Giulia, additional, Andreone, Pietro, additional, Aghemo, Alessio, additional, Popoli, Patrizia, additional, and Vella, Stefano, additional

Published
2023
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12. Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Tosti, Maria Elena, additional, Quaranta, Maria Giovanna, additional, Ciancio, Alessia, additional, Messina, Vincenzo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Capasso, Mario, additional, Rosato, Valerio, additional, Cacciola, Irene, additional, Pasulo, Luisa, additional, Santantonio, Teresa, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Barbaro, Francesco, additional, Massari, Marco, additional, Coppola, Nicola, additional, Ferrarese, Alberto, additional, Russo, Francesco Paolo, additional, Di Marco, Vito, additional, Marrone, Aldo, additional, Schivazappa, Simona, additional, Federico, Alessandro, additional, Blanc, Pierluigi, additional, Rocco, Alba, additional, Morsica, Giulia, additional, Ieluzzi, Donatella, additional, Conti, Fabio, additional, De Siena, Martina, additional, Bavetta, Maria Grazia, additional, Milella, Michele, additional, Gentile, Ivan, additional, Porcu, Carmen, additional, Chemello, Liliana, additional, Maracci, Monia, additional, Zignego, Anna Linda, additional, Baiocchi, Leonardo, additional, Maida, Ivana Rita, additional, and Coco, Barbara, additional

Published
2023
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14. Predicting de‐novoportal vein thrombosis after HCV eradication: A long‐term competing risk analysis in the ongoing PITER cohort

Author

Kondili, Loreta A., Zanetto, Alberto, Quaranta, Maria Giovanna, Ferrigno, Luigina, Panetta, Valentina, Calvaruso, Vincenza, Zignego, Anna Linda, Brunetto, Maurizia R., Raimondo, Giovanni, Biliotti, Elisa, Ieluzzi, Donatella, Iannone, Andrea, Madonia, Salvatore, Chemello, Liliana, Cavalletto, Luisa, Coppola, Carmine, Morisco, Filomena, Barbaro, Francesco, Licata, Anna, Federico, Alessandro, Cerini, Federica, Persico, Marcello, Pompili, Maurizio, Ciancio, Alessia, Piscaglia, Fabio, Chessa, Luchino, Giacometti, Andrea, Invernizzi, Pietro, Brancaccio, Giuseppina, Benedetti, Antonio, Baiocchi, Leonardo, Gentile, Ivan, Coppola, Nicola, Nardone, Gerardo, Craxì, Antonio, Russo, Francesco Paolo, Monti, Monica, Coco, Barbara, Filomia, Roberto, Bruno, Erica Maria, Cossiga, Valentina, Amodeo, Simona, Dallio, Marcello, Crapanzano, Luciano, Masarone, Mario, De Siena, Martina, Serio, Ilaria, Loi, Martina, Brescini, Lucia, Ciaccio, Antonio, Cucco, Monica, Tata, Xhimi, Sagnelli, Caterina, Sgamato, Costantino, Claar, Ernesto, Rosselli Del Turco, Elena, Rumi, Maria Grazia, Gaeta, Giovanni Battista, and Simioni, Paolo

Abstract

Sustained virological response (SVR) by direct‐acting antivirals (DAAs) may reverse the hypercoagulable state of HCV cirrhosis and the portal vein thrombosis (PVT) risk. We evaluated the incidence and predictive factors of de novo, non‐tumoral PVT in patients with cirrhosis after HCV eradication. Patients with HCV‐related cirrhosis, consecutively enrolled in the multi‐center ongoing PITER cohort, who achieved the SVR using DAAs, were prospectively evaluated. Kaplan‐Meier and competing risk regression analyses were performed. During a median time of 38.3 months (IQR: 25.1–48.7 months) after the end of treatment (EOT), among 1609 SVR patients, 32 (2.0%) developed de novo PVT. A platelet count ≤120,000/μL, albumin levels ≤3.5 mg/dL, bilirubin >1.1 mg/dL, a previous liver decompensation, ALBI, Baveno, FIB‐4, and RESIST scores were significantly different (p< 0.001), among patients who developed PVT versus those who did not. Considering death and liver transplantation as competing risk events, esophageal varices (subHR: 10.40; CI 95% 4.33–24.99) and pre‐treatment ALBI grade ≥2 (subHR: 4.32; CI 95% 1.36–13.74) were independent predictors of PVT. After HCV eradication, a significant variation in PLT count, albumin, and bilirubin (p< 0.001) versus pre‐treatment values was observed in patients who did not develop PVT, whereas no significant differences were observed in those who developed PVT (p> 0.05). After the EOT, esophageal varices and ALBI grade ≥2, remained associated with de novo PVT (subHR: 9.32; CI 95% 3.16–27.53 and subHR: 5.50; CI 95% 1.67–18.13, respectively). In patients with HCV‐related cirrhosis, a more advanced liver disease and significant portal hypertension are independently associated with the de novo PVT risk after SVR.

Published
2024
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15. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Brancaccio, Giuseppina, primary, Coco, Barbara, additional, Nardi, Alessandra, additional, Quaranta, Maria Giovanna, additional, Tosti, Maria Elena, additional, Ferrigno, Luigina, additional, Cacciola, Irene, additional, Messina, Vincenzo, additional, Chessa, Luchino, additional, Morisco, Filomena, additional, Milella, Michele, additional, Barbaro, Francesco, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Coppola, Nicola, additional, Blanc, Pierluigi, additional, Claar, Ernesto, additional, Verucchi, Gabriella, additional, Puoti, Massimo, additional, Zignego, Anna Linda, additional, Chemello, Liliana, additional, Madonia, Salvatore, additional, Fagiuoli, Stefano, additional, Marzano, Alfredo, additional, Ferrari, Carlo, additional, Lampertico, Pietro, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Santantonio, Teresa Antonia, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Gaeta, Giovanni Battista, additional, Kondili, Loreta A., additional, Pasulo, Luisa, additional, Coppola, Carmine, additional, Pisano, Federica, additional, Romano, Mariarosaria, additional, Porcu, Carmen, additional, Bottalico, Irene Francesca, additional, Cossiga, Valentina, additional, Tata, Xhimi, additional, Sagnelli, Caterina, additional, Pierotti, Piera, additional, Degasperi, Elisabetta, additional, Rosato, Valerio, additional, Badia, Lorenzo, additional, Ieluzzi, Dontella, additional, Monti, Monica, additional, Bavetta, Maria Grazia, additional, Cavalletto, Luisa, additional, Toniutto, Pierluigi, additional, Fornasiere, Ezio, additional, Colecchia, Antonio, additional, Ferrarese, Alberto, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Viganò, Mauro, additional, Foschi, Francesco Giuseppe, additional, Conti, Fabio, additional, Morsica, Giulia, additional, Salpietro, Stefania, additional, Torti, Carlo, additional, Costa, Chiara, additional, Federico, Alessandro, additional, Dallio, Marcello, additional, Giorgini, Alessia, additional, Anselmo, Marco, additional, De Leo, Pasqualina, additional, Zaltron, Serena, additional, Cambianica, Anna, additional, Piscaglia, Fabio, additional, Serio, Ilaria, additional, Schivazappa, Simona, additional, Mastroianni, Antonio, additional, Chidichimo, Luciana, additional, Massari, Marco, additional, Mazzaro, Cesare, additional, Marrone, Aldo, additional, D'Amore, Francesca Maria, additional, D'Offizi, Gianpiero, additional, Licata, Anna, additional, Niro, Grazia Anna, additional, Pollicino, Teresa, additional, and Aghemo, Alessio, additional

Published
2023
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17. Modeling cost‐effectiveness and health gains of a “universal” versus “prioritized” hepatitis C virus treatment policy in a real‐life cohort

Author

Kondili, Loreta A., Romano, Federica, Rolli, Francesca Romana, Ruggeri, Matteo, Rosato, Stefano, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Ciancio, Alessia, Di Leo, Alfredo, Raimondo, Giovanni, Ferrari, Carlo, Taliani, Gloria, Borgia, Guglielmo, Santantonio, Teresa Antonia, Blanc, Pierluigi, Gaeta, Giovanni Battista, Gasbarrini, Antonio, Chessa, Luchino, Erne, Elke Maria, Villa, Erica, Ieluzzi, Donatella, Russo, Francesco Paolo, Andreone, Pietro, Vinci, Maria, Coppola, Carmine, Chemello, Liliana, Madonia, Salvatore, Verucchi, Gabriella, Persico, Marcello, Zuin, Massimo, Puoti, Massimo, Alberti, Alfredo, Nardone, Gerardo, Massari, Marco, Montalto, Giuseppe, Foti, Giuseppe, Rumi, Maria Grazia, Quaranta, Maria Giovanna, Cicchetti, Americo, Craxì, Antonio, and Vella, Stefano

Published
2017
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19. A prospective study of direct‐acting antiviral effectiveness and relapse risk in HCV cryoglobulinemic vasculitis by the Italian PITER cohort

Author

Kondili, Loreta A., primary, Monti, Monica, additional, Quaranta, Maria Giovanna, additional, Gragnani, Laura, additional, Panetta, Valentina, additional, Brancaccio, Giuseppina, additional, Mazzaro, Cesare, additional, Persico, Marcello, additional, Masarone, Mario, additional, Gentile, Ivan, additional, Andreone, Pietro, additional, Madonia, Salvatore, additional, Biliotti, Elisa, additional, Filomia, Roberto, additional, Puoti, Massimo, additional, Fracanzani, Anna Ludovica, additional, Laccabue, Diletta, additional, Ieluzzi, Donatella, additional, Coppola, Carmine, additional, Rumi, Maria Grazia, additional, Benedetti, Antonio, additional, Verucchi, Gabriella, additional, Coco, Barbara, additional, Chemello, Liliana, additional, Iannone, Andrea, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Barbaro, Francesco, additional, Morisco, Filomena, additional, Chessa, Luchino, additional, Massari, Marco, additional, Blanc, Pierluigi, additional, and Zignego, Anna Linda, additional

Published
2022
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20. 613 Fontan associated nephropathy: does diastolic function play a role?

Author

Rotella, Marta, primary, Meneghesso, Davide, additional, Sabatino, Jolanda, additional, Biffanti, Roberta, additional, Partigiani, Nicola Bertazza, additional, Binda, Beatrice, additional, Puricelli, Filippo, additional, Chemello, Liliana, additional, Cavalletto, Luisa, additional, Padalino, Massimo, additional, and Salvo, Giovanni Di, additional

Published
2021
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21. 610 Fontan associated kidney and liver disease: can we predict organ involvement with echocardiographic assessment of systolic function and atrioventricular valve insufficiency?

Author

Rotella, Marta, primary, Biffanti, Roberta, additional, Sabatino, Jolanda, additional, Meneghesso, Davide, additional, Partigiani, Nicola Bertazza, additional, Basso, Alessia, additional, Binda, Beatrice, additional, Chemello, Liliana, additional, Cavalletto, Luisa, additional, Padalino, Massimo, additional, and Di Salvo, Giovanni, additional

Published
2021
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24. A prospective study of DAA Effectiveness and Relapse Risk in HCV Cryoglobulinemic Vasculitis by the Italian PITER Cohort

Author

Kondili, Loreta A, Monti, Monica, Quaranta, Maria Giovanna, Gragnani, Laura, Panetta, Valentina, Brancaccio, Giuseppina, Mazzaro, Cesare, Persico, Marcello, Masarone, Mario, Gentile, Ivan, Andreone, Pietro, Madonia, Salvatore, Biliotti, Elisa, Filomia, Roberto, Puoti, Massimo, Fracanzani, Anna Ludovica, Laccabue, Diletta, Ieluzzi, Donatella, Coppola, Carmine, Rumi, Maria Grazia, Benedetti, Antonio, Verucchi, Gabriella, Coco, Barbara, Chemello, Liliana, Iannone, Andrea, Ciancio, Alessia, Russo, Francesco Paolo, Barbaro, Francesco, Morisco, Filomena, Chessa, Luchino, Massari, Marco, Blanc, Pierluigi, and Zignego, Anna Linda

Subjects
Direct Acting Antivirals, Mixed Cryoglobulinemia, Clinical Response, Cryoglobulinemic Vasculitis, HCV-chronic infection
Published
2021

25. Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome

Author

Bettini, Silvia, primary, Bombonato, Giancarlo, additional, Dassie, Francesca, additional, Favaretto, Francesca, additional, Piffer, Luca, additional, Bizzotto, Paola, additional, Busetto, Luca, additional, Chemello, Liliana, additional, Senzolo, Marco, additional, Merkel, Carlo, additional, Angeli, Paolo, additional, Vettor, Roberto, additional, Milan, Gabriella, additional, and Maffei, Pietro, additional

Published
2021
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26. Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis

Author

Sapena, Victor, primary, Enea, Marco, additional, Torres, Ferran, additional, Celsa, Ciro, additional, Rios, Jose, additional, Rizzo, Giacomo Emanuele Maria, additional, Nahon, Pierre, additional, Mariño, Zoe, additional, Tateishi, Ryosuke, additional, Minami, Tatsuya, additional, Sangiovanni, Angelo, additional, Forns, Xavier, additional, Toyoda, Hidenori, additional, Brillanti, Stefano, additional, Conti, Fabio, additional, Degasperi, Elisabetta, additional, Yu, Ming-Lung, additional, Tsai, Pei-Chien, additional, Jean, Kevin, additional, El Kassas, Mohamed, additional, Shousha, Hend Ibrahim, additional, Omar, Ashraf, additional, Zavaglia, Claudio, additional, Nagata, Hiroko, additional, Nakagawa, Mina, additional, Asahina, Yasuhiro, additional, Singal, Amit G, additional, Murphy, Caitlin, additional, Kohla, Mohamed, additional, Masetti, Chiara, additional, Dufour, Jean-François, additional, Merchante, Nicolas, additional, Cavalletto, Luisa, additional, chemello, liliana LC, additional, POL, Stanislas, additional, Crespo, Javier, additional, Calleja, Jose Luis, additional, Villani, Rosanna, additional, Serviddio, Gaetano, additional, Zanetto, Alberto, additional, Shalaby, Sarah, additional, Russo, Francesco Paolo, additional, Bielen, Rob, additional, Trevisani, Franco, additional, Cammà, Calogero, additional, Bruix, Jordi, additional, Cabibbo, Giuseppe, additional, and Reig, Maria, additional

Published
2021
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28. WED-146 - Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, Tosti, Maria Elena, Quaranta, Maria Giovanna, Ciancio, Alessia, Messina, Vincenzo, Brancaccio, Giuseppina, Brunetto, Maurizia, Capasso, Mario, Rosato, Valerio, Cacciola, Irene, Pasulo, Luisa, Santantonio, Teresa, Coppola, Carmine, Biliotti, Elisa, Barbaro, Francesco, Massari, Marco, Coppola, Nicola, Ferrarese, Alberto, Russo, Francesco Paolo, Di Marco, Vito, Marrone, Aldo, Schivazappa, Simona, Federico, Alessandro, Blanc, Pierluigi, Rocco, Alba, Morsica, Giulia, Ieluzzi, Donatella, Conti, Fabio, De Siena, Martina, Bavetta, Maria Grazia, Milella, Michele, Gentile, Ivan, Porcu, Carmen, Chemello, Liliana, Maracci, Monia, Zignego, Anna Linda, Baiocchi, Leonardo, Maida, Ivana Rita, and Coco, Barbara

Published
2023
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30. The weight of pre-existing cofactors for liver disease progression in patients who successfully eradicated chronic hepatitis C viral infection: an interim analysis in the PITER cohort

Author

Kondili, Loreta, primary, Quaranta, Maria Giovanna, additional, Monti, Monica, additional, Amoruso, Daniela Caterina, additional, Filomia, Roberto, additional, Biliotti, Elisa, additional, Iannone, Andrea, additional, Ieluzzi, Donatella, additional, Coco, Barbara, additional, Russo, Francesco Paolo, additional, Beretta, Ilaria, additional, Parruti, Giustino, additional, Blanc, Pierluigi, additional, Vinci, Maria, additional, Cossiga, Valentina, additional, Degasperi, Elisabetta, additional, Chemello, Liliana, additional, Massari, Marco, additional, Badia, Lorenzo, additional, Puoti, Massimo, additional, Bruno, Serena, additional, De Siena, Martina, additional, Panetta, Valentina, additional, and Aghemo, Alessio, additional

Published
2020
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31. Surgical management of failing Fontan circulation: results from 30 cases with 285 patient-years follow-up.

Author

Padalino, Massimo A, Ponzoni, Matteo, Castaldi, Biagio, Leoni, Loira, Chemello, Liliana, Toscano, Giuseppe, Gerosa, Gino, Salvo, Giovanni Di, and Vida, Vladimiro L

Subjects
CARDIAC surgery, REOPERATION, HEART transplantation, OVERALL survival, TACHYARRHYTHMIAS, SURGICAL complications
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Fontan patients are known to suffer from clinical attrition over the years, which has been characterized as Fontan failure. We sought to evaluate the clinical outcomes of such Fontan patients undergoing surgical management in a 25-year, single-centre experience. METHODS A retrospective single-centre analysis of patients undergoing surgical treatment for failing Fontan between 1995 and 2020, including any reoperations when ventricular function was preserved, or a heart transplant (HTx), when ventricular contractility was impaired. We analysed survival, indications for surgery and early and late complication rates. RESULTS We collected 30 patients (mean age 24.7 years) who required surgery after a mean time of 19.3 years from the original Fontan procedure: Fontan conversion in 21 (70%, extracardiac conduit in 19, lateral tunnel in 2), a HTx in 4 (13.3%) and other reoperations in 5 (16.7%). The most common indications for surgery were tachyarrhythmias (63.3%) and severe right atrial dilatation (63.3%). Overall survival at the 1-, 5-, 10- and 20-year follow-up examinations were 75.9% [95% confidence interval (CI): 91.4–60.4%], 75.9% (95% CI: 91.4–60.4%), 70% (95% CI: 78–52%) and 70% (95% CI: 78–52%), respectively. The most frequent complications were postoperative tachyarrhythmias (50%) and late Fontan-associated liver disease (56.5%). HTx and Fontan conversion provided comparably good outcomes compared to other reoperations (P  = 0.022). CONCLUSIONS Surgery for failing Fontan can be performed effectively with overall good long-term survival. However, early and late morbidities are still a significant burden. Because other reoperations performed when patients presented with contraindications for a HTx have carried high mortality, close clinical follow-up is mandatory, and an earlier indication for Fontan conversion or a HTx is advisable to optimize outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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34. THU-141-Efficacy and safety of elbasvir/grazoprevir in a large real-life cohort of HCV-infected patients

Author

Gambato, Martina, primary, Spinetti, Angiola, additional, Pasulo, Luisa, additional, D’ambrosio, Roberta, additional, Puoti, Massimo, additional, Schiavini, Monica, additional, Fabris, Paolo, additional, Sacchi, Paolo, additional, Gulminetti, Roberto, additional, Carolo, Giada, additional, Scotton, Piergiorgio, additional, Pozzan, Caterina, additional, Vinci, Maria, additional, Viganò, Mauro, additional, Lobello, Salvatore, additional, Zuin, Massimo Giovanni, additional, Aghemo, Alessio, additional, Rumi, Maria Grazia, additional, Carrara, Maurizio, additional, Manfrin, Vinicio, additional, Uberti-Foppa, Caterina, additional, Panese, Sandro, additional, Cattelan, Francesca, additional, Paon, Veronica, additional, Pan, Angelo, additional, Spinelli, Ombretta, additional, Monforte, Antonella d'Arminio, additional, Colli, Agostino, additional, Spinzi, Giancarlo, additional, Russo, Francesco Paolo, additional, Chemello, Liliana, additional, Vincenzi, Valter, additional, Grossi, Paolo Antonio, additional, Buscarini, Elisabetta, additional, Cardaci, Giovanna, additional, Soria, Alessandro, additional, Menzaghi, Barbara, additional, Mendeni, Monia, additional, Degasperi, Elisabetta, additional, Soffredini, Roberta, additional, Colpani, Maria, additional, Comi, Laura, additional, Zuccaro, Valentina, additional, Zaltron, Serena, additional, Gori, ANDREA, additional, Poggio, Paolo Del, additional, Giorgini, Alessia, additional, Capretti, Andrea, additional, Memoli, massimo, additional, Pigozzi, Marie Graciella, additional, Rossi, Maria Cristina, additional, Cavalletto, Luisa, additional, Capra, Franco, additional, Colombo, Alberto, additional, Dibenedetto, Clara, additional, Landonio, Simona, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, Castelli, Francesco, additional, Alberti, Alfredo, additional, and Fagiuoli, Stefano, additional

Published
2019
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35. SAT-262-Long-term liver function outcome and related risk factors in HCV cirrhotic patients treated with direct-acting antiviral therapy: Results from the Navigatore platform in Veneto-Italy

Author

Russo, Francesco Paolo, primary, Gambato, Martina, additional, Piovesan, Sara, additional, Romano, Antonietta, additional, Lobello, Salvatore, additional, Panese, sandro, additional, Paon, Veronica, additional, Tosca, Bertin, additional, Vincenzi, Valter, additional, Franceschet, Irene, additional, Pozzan, Caterina, additional, Angeli, Paolo, additional, Chemello, Liliana, additional, Noventa, Franco, additional, Carolo, Giada, additional, Cattelan, Annamaria, additional, Burra, Patrizia, additional, and Alberti, Alfredo, additional

Published
2019
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36. THU-166-Treatment of 320 genotype 3 cirrhotic patients with 12 weeks of sofosbuvir/velpatasvir with or without ribavirin: Real life experience from Italy

Author

Pasulo, Luisa, primary, Gambato, Martina, additional, Spinetti, Angiola, additional, D’ambrosio, Roberta, additional, Puoti, Massimo, additional, Ciancio, Alessia, additional, Marco, Vito Di, additional, Calvaruso, Vincenza, additional, Piero, Colombatto, additional, Brunetto, Maurizia, additional, Schiavini, Monica, additional, Sacchi, Paolo, additional, Gulminetti, Roberto, additional, Carolo, Giada, additional, Scotton, Piergiorgio, additional, Pozzan, Caterina, additional, Vinci, Maria, additional, Vigano, Mauro, additional, Lombardi, Andrea, additional, Lobello, Salvatore, additional, Zuin, Massimo Giovanni, additional, Aghemo, Alessio, additional, Rumi, Maria Grazia, additional, Manfrin, Vinicio, additional, Uberti-Foppa, Caterina, additional, Panese, Sandro, additional, Paon, Veronica, additional, Pan, Angelo, additional, Spinelli, Ombretta, additional, Monforte, Antonella d’Arminio, additional, Colli, Agostino, additional, Spinzi, Giancarlo, additional, Russo, Francesco Paolo, additional, Chemello, Liliana, additional, Vincenzi, Valter, additional, Grossi, Paolo Antonio, additional, Buscarini, Elisabetta, additional, Soria, Alessandro, additional, Menzaghi, Barbara, additional, Mendeni, Monia, additional, Soffredini, Roberta, additional, Colpani, Maria, additional, Zaltron, Serena, additional, Gori, ANDREA, additional, Giorgini, Alessia, additional, Cologni, Giuliana, additional, Cartabellotta, Fabio, additional, Difrancesco, Lorenzo, additional, Cacciola, Irene, additional, Albanese, Antonio, additional, Rosolini, Maria Antonietta Di, additional, Giacomo, Antonio Di, additional, Capretti, Andrea, additional, Memoli, massimo, additional, Cavalletto, Luisa, additional, Capra, Franco, additional, Colombo, Alberto, additional, Dibenedetto, Clara, additional, Magni, Carlo Federico, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, Castelli, Francesco, additional, Alberti, Alfredo, additional, and Fagiuoli, Stefano, additional

Published
2019
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37. Modelling cost-effectiveness and health gains of a 'universal' vs. 'prioritized' HCV treatment policy in a real-life cohort

Author

Kondili, Loreta A, Romano, Federica, Rolli, Francesca Romana, Ruggeri, Matteo, Rosato, Stefano, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Ciancio, Alessia, Di Leo, Alfredo, Raimondo, Giovanni, Ferrari, Carlo, Taliani, Gloria, Borgia, Guglielmo, Santantonio, Teresa Antonia, Blanc, Pierluigi, GAETA, Giovanni Battista, Gasbarrini, Antonio, Chessa, Luchino, Erne, Elke Maria, Villa, Erica, Ieluzzi, Donatella, Russo, Francesco Paolo, Andreone, Pietro, Vinci, Maria, Coppola, Carmine, Chemello, Liliana, Madonia, Salvatore, Verucchi, Gabriella, Persico, Marcello, Zuin, Massimo, Puoti, Massimo, Alberti, Alfredo, Nardone, Gerardo, Massari, Marco, Montalto, Giuseppe, Foti, Giuseppe, Rumi, Maria Grazia, Quaranta, Maria Giovanna, Cicchetti, Americo, Craxì, Antonio, Vella, Stefano, PITER Collaborating Group, FEDERICO, Alessandro, Dallio M, LOGUERCIO, Carmelina, Kondili, Loreta A, Romano, Federica, Rolli, Francesca Romana, Ruggeri, Matteo, Rosato, Stefano, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Ciancio, Alessia, Di Leo, Alfredo, Raimondo, Giovanni, Ferrari, Carlo, Taliani, Gloria, Borgia, Guglielmo, Santantonio, Teresa Antonia, Blanc, Pierluigi, Gaeta, Giovanni Battista, Gasbarrini, Antonio, Chessa, Luchino, Erne, Elke Maria, Villa, Erica, Ieluzzi, Donatella, Russo, Francesco Paolo, Andreone, Pietro, Vinci, Maria, Coppola, Carmine, Chemello, Liliana, Madonia, Salvatore, Verucchi, Gabriella, Persico, Marcello, Zuin, Massimo, Puoti, Massimo, Alberti, Alfredo, Nardone, Gerardo, Massari, Marco, Montalto, Giuseppe, Foti, Giuseppe, Rumi, Maria Grazia, Quaranta, Maria Giovanna, Cicchetti, Americo, Craxì, Antonio, Vella, Stefano, PITER Collaborating, Group, Federico, Alessandro, Dallio, M, and Loguercio, Carmelina

Subjects
real-life cohort, HCV, antiviral therapy, cost-effectivene, Hepatitis C
Abstract

We evaluated the cost-effectiveness of two alternative DAA treatment policies in a real-life cohort of HCV-infected patients: Policy 1 - "universal": treat all patients, regardless of the fibrosis stage; Policy 2 - treat only "prioritized" patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and healthcare system perspective, was applied to the PITER cohort (representative of Italian HCV-infected patients in care). Specifically, 8,125 patients naïve to DAA treatment, without clinical, sociodemographic or insurance restrictions was used to evaluate the policies' cost-effectiveness. The patients' age, fibrosis stage, assumed DAA treatment cost of €15,000/patient and the Italian liver disease costs were used to evaluate Quality-Adjusted Life-Years (QALY) This article is protected by copyright. All rights reserved.

Published
2017

38. Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis

Author

Sapena, Victor, Enea, Marco, Torres, Ferran, Celsa, Ciro, Rios, Jose, Rizzo, Giacomo Emanuele Maria, Nahon, Pierre, Mariño, Zoe, Tateishi, Ryosuke, Minami, Tatsuya, Sangiovanni, Angelo, Forns, Xavier, Toyoda, Hidenori, Brillanti, Stefano, Conti, Fabio, Degasperi, Elisabetta, Yu, Ming-Lung, Tsai, Pei-Chien, Jean, Kevin, El Kassas, Mohamed, Shousha, Hend Ibrahim, Omar, Ashraf, Zavaglia, Claudio, Nagata, Hiroko, Nakagawa, Mina, Asahina, Yasuhiro, Singal, Amit G, Murphy, Caitlin, Kohla, Mohamed, Masetti, Chiara, Dufour, Jean-Francois, Merchante, Nicolas, Cavalletto, Luisa, chemello, liliana LC, POL, Stanislas, Crespo, Javier, Calleja, Jose Luis, Villani, Rosanna, Serviddio, Gaetano, Zanetto, Alberto, Shalaby, Sarah, Russo, Francesco Paolo, Bielen, Rob, Trevisani, Franco, Cammà, Calogero, Bruix, Jordi, Cabibbo, Giuseppe, and Reig, Maria

Abstract

ObjectiveThe benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration.DesignWe pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death risk was expressed as HCC recurrence or death per 100 person-years (100PY). Propensity score-matched patients from the ITA.LI.CA. cohort (n=328) served as DAA-unexposed controls (no-DAA group). Risk factors for HCC recurrence were identified using random-effects Poisson.ResultsRecurrence rate and death risk per 100PY in DAA-treated patients were 20 (95% CI 13.9 to 29.8, I2=74.6%) and 5.7 (2.5 to 15.3, I2=54.3), respectively. Predictive factors for recurrence were alpha-fetoprotein logarithm (relative risk (RR)=1.11, 95% CI 1.03 to 1.19; p=0.01, per 1 log of ng/mL), HCC recurrence history pre-DAA initiation (RR=1.11, 95% CI 1.07 to 1.16; p<0.001), performance status (2 vs 0, RR=4.35, 95% CI 1.54 to 11.11; 2 vs 1, RR=3.7, 95% CI 1.3 to 11.11; p=0.01) and tumour burden pre-HCC treatment (multifocal vs solitary nodule, RR=1.75, 95% CI 1.25 to 2.43; p<0.001). No significant difference was observed in RR between the DAA-exposed and DAA-unexposed groups in propensity score-matched patients (RR=0.64, 95% CI 0.37 to 1.1; p=0.1).ConclusionEffects of DAA exposure on HCC recurrence risk remain inconclusive. Active clinical and radiological follow-up of patients with HCC after HCV eradication with DAA is justified.

Published
2022
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39. Liver Angiopoietin-2 is a key predictor of de novo or recurrent hepatocellular cancer after HCV direct-acting antivirals

Author

Faillaci, Francesca, Marzi, Luca, Critelli, Rosina, Milosa, Fabiola, Schepis, Filippo, Turola, Elena, Andreani, Silvia, Vandelli, Gabriele, Bernabucci, Veronica, Lei, Barbara, D'Ambrosio, Federica, Bristot, Laura, Cavalletto, Luisa, Chemello, Liliana, Sighinolfi, Pamela, Manni, Paola, Maiorana, Antonino, Caporali, Cristian, Bianchini, Marcello, Marsico, Maria, Turco, Laura, de Maria, Nicola, Del Buono, Mariagrazia, Todesca, Paola, di Lena, Luca, Romagnoli, Dante, Magistri, Paolo, di Benedetto, Fabrizio, Bruno, Savino, Taliani, Gloria, Giannelli, Gianluigi, Martinez-Chantar, Maria-Luz, and Villa, Erica

Subjects
Shear stress, Fibrosis, Liver stiffness, Portal hypertension, Vascular endothelial growth factor
Published
2018

40. Real-Life use of Elbasvir/Grazoprevir in Adults and Elderly Patients: A Prospective Evaluation of Comedications used in the PITER Cohort

Author

Quaranta, Maria Giovanna, primary, Rosato, Stefano, additional, Ferrigno, Luigina, additional, Amoruso, Daniela Caterina, additional, Monti, Monica, additional, Di Stefano, Paola, additional, Filomia, Roberto, additional, Biliotti, Elisa, additional, Migliorino, Guglielmo, additional, Russo, Francesco Paolo, additional, Degasperi, Elisabetta, additional, Chemello, Liliana, additional, Brancaccio, Giuseppina, additional, Blanc, Pierluigi, additional, Cannizzaro, Marco, additional, Barbaro, Francesco, additional, Morsica, Giulia, additional, Licata, Anna, additional, and Kondili, Loreta A, additional

Published
2019
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41. Advanced liver disease outcomes after hepatitis C eradication by human immunodeficiency virus infection in PITER cohort.

Author

Quaranta, Maria Giovanna, Ferrigno, Luigina, Monti, Monica, Filomia, Roberto, Biliotti, Elisa, Iannone, Andrea, Migliorino, Guglielmo, Coco, Barbara, Morisco, Filomena, Vinci, Maria, D'Ambrosio, Roberta, Chemello, Liliana, Massari, Marco, Ieluzzi, Donatella, Russo, Francesco Paolo, Blanc, Pierluigi, Verucchi, Gabriella, Puoti, Massimo, Rumi, Maria Grazia, and Barbaro, Francesco

Abstract

Background: Liver disease progression after Hepatitis C Virus (HCV) eradication following direct-acting antiviral (DAA) treatment in the real-life setting according to Human Immunodeficiency Virus (HIV) coinfection was evaluated. Methods: Patients consecutively enrolled in PITER between April 2014 and June 2019 and with at least 12-weeks follow-up following treatment were analysed. Cox regression analysis were used to evaluate HIV coinfection and factors independently associated with liver disease outcomes following viral eradication in DAA treated patients with pre-treatment liver cirrhosis. Results: 93 HIV/HCV coinfected and 1109 HCV monoinfected patients were evaluated during a median follow-up of 26.7 (range 6–44.6) and 24.6 (range 6.8–47.3) months, respectively. No difference in the cumulative HCC incidence and hepatic decompensation was observed between coinfected and monoinfected patients. Age (Hazard Ratio [HR] = 1.08; 95% CI 1.04–1.13), male sex (HR = 2.76; 95% CI 1.28–5.96), lower albumin levels (HR = 3.94; 95% CI 1.81–8.58), genotype 3 (HR = 5.05; 95% CI 1.75–14.57) and serum anti-HBc positivity (HR = 1.99, 95% CI 1.01–3.95) were independently associated with HCC incidence. Older age (HR = 1.03; 95% CI 1.00–1.07), male sex (HR = 2.13; 95% CI 1.06–4.26) and lower albumin levels (HR = 3.75; 95% CI 1.89–7.46) were independently associated with the appearance of a decompensating event after viral eradication. Conclusion: Different demographic, clinical and genotype distribution between HIV coinfected vs those monoinfected, was observed in a representative cohort of HCV infected patients in Italy. Once liver cirrhosis is established the disease progression is decreased, but still persists regardless of viral eradication in both coinfected and monoinfected patients. In patients with cirrhosis, HIV coinfection was not associated with a higher probability of liver complications, after viral eradication. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Liver Angiopoietin‐2 Is a Key Predictor of D e N ovo or Recurrent Hepatocellular Cancer After Hepatitis C Virus Direct‐Acting Antivirals

Author

Faillaci, Francesca, primary, Marzi, Luca, additional, Critelli, Rosina, additional, Milosa, Fabiola, additional, Schepis, Filippo, additional, Turola, Elena, additional, Andreani, Silvia, additional, Vandelli, Gabriele, additional, Bernabucci, Veronica, additional, Lei, Barbara, additional, D'Ambrosio, Federica, additional, Bristot, Laura, additional, Cavalletto, Luisa, additional, Chemello, Liliana, additional, Sighinolfi, Pamela, additional, Manni, Paola, additional, Maiorana, Antonino, additional, Caporali, Cristian, additional, Bianchini, Marcello, additional, Marsico, Maria, additional, Turco, Laura, additional, de Maria, Nicola, additional, Del Buono, Mariagrazia, additional, Todesca, Paola, additional, di Lena, Luca, additional, Romagnoli, Dante, additional, Magistri, Paolo, additional, di Benedetto, Fabrizio, additional, Bruno, Savino, additional, Taliani, Gloria, additional, Giannelli, Gianluigi, additional, Martinez‐Chantar, Maria‐Luz, additional, and Villa, Erica, additional

Published
2018
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43. FRI442 - The weight of pre-existing cofactors for liver disease progression in patients who successfully eradicated chronic hepatitis C viral infection: an interim analysis in the PITER cohort

Author

Kondili, Loreta, Quaranta, Maria Giovanna, Monti, Monica, Amoruso, Daniela Caterina, Filomia, Roberto, Biliotti, Elisa, Iannone, Andrea, Ieluzzi, Donatella, Coco, Barbara, Russo, Francesco Paolo, Beretta, Ilaria, Parruti, Giustino, Blanc, Pierluigi, Vinci, Maria, Cossiga, Valentina, Degasperi, Elisabetta, Chemello, Liliana, Massari, Marco, Badia, Lorenzo, Puoti, Massimo, Bruno, Serena, De Siena, Martina, Panetta, Valentina, and Aghemo, Alessio

Published
2020
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44. Sofosbuvir plus ribavirin for difficult to treat HCV-2: improved efficacy with extended treatment duration

Author

Piovesan, Sara, Capra, Franco, Russo, Francesco P., Chemello, Liliana, Cavalletto, Luisa, Rossi, Cristina, Scotton, Piergiorgio, Manuppelli, Carlo, Cattelan, Francesca, Panese, Sandro, Zanetto, Alberto, Burra, Patrizia, Ieluzzi, Donatella, Paon, Veronica, Felder, Martina, Carolo, Giada, Carlotto, Antonio, Erne, Elke M., Lobello, Salvatore, Roni, Chiara, Scroccaro, Giovanna, and Alberti, Alfredo

Subjects
sofosbuvir, HCV-2, duration treatment, HCV-2, duration treatment, sofosbuvir
Published
2016

45. Efficacy and safety of oral DAAs HCV therapy in the elderly

Author

Russo, Francesco P., Piovesan, Sara, Chemello, Liliana, Guzzo, Francesco, Tempesta, Diego, Panese, Sandro, Cavalletto, Luisa, Gonzo, Marysol, Capra, Franco, Carolo, Giada, Barbaro, Francesco, Angeli, Paolo, Ieluzzi, Donatella, Lobello, Salvatore, Adami, Silvia, Scroccaro, Giovanna, and Alberti, Alfredo

Subjects
HCV therapy, DAAs, elderly, DAAs, HCV therapy, elderly
Published
2016

46. Efficacy and safety of DAA-based oral therapy i9n a large cohort of HCV patients treated in clinical practice in Italy and monitored by the NAVIGATORE web-platform

Author

Milan, Marta, Scotton, Piergiorgio, Cavallaro, Lucas G., Basso, Monica, Panese, Sandro, Tempesta, Diego, Piovesan, Sara, Cattelan, Anna Maria, Campagnolo, Davide, Burra, Patrizia, Russo, Francesco P., Carlotto, Antonio, Angeli, Paolo, Vario, Alessandro, Fabris, Paolo, Bertin, Tosca, Carrara, Maurizio, Chemello, Liliana, Rovere, Pierangelo, Capra, Franco, Carolo, Giada, Lobello, Salvatore, Adami, Silvia, Scroccaro, Giovanna, and Alberti, Alfredo

Subjects
DAAs oral therapy
Published
2016

47. Incidence and pattern of 'de novo'hepatocellular carcinoma in HCV patients treated with oral DAAs

Author

Romano, Antonietta, Capra, Franco, Piovesan, Sara, Chemello, Liliana, Cavalletto, Luisa, Anastassopulos, Georgios, Vincenzi, Valter, Scotton, Piergiorgio, Panese, Sandro, Tempesta, Diego, Gambato, Martina, Russo, Francesco P., Bertin, Tosca, Carrara, Maurizio, Carlotto, Antonio, Carolo, Giada, Scroccaro, Giovanna, and Alberti, Alfredo

Subjects
HCC, HCV patients, oral DAAs, oral DAAs, HCC, HCV patients
Published
2016

48. Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network

Author

Kondili, Loreta A., primary, Gaeta, Giovanni Battista, additional, Brunetto, Maurizia Rossana, additional, Di Leo, Alfredo, additional, Iannone, Andrea, additional, Santantonio, Teresa Antonia, additional, Giammario, Adele, additional, Raimondo, Giovanni, additional, Filomia, Roberto, additional, Coppola, Carmine, additional, Amoruso, Daniela Caterina, additional, Blanc, Pierluigi, additional, Del Pin, Barbara, additional, Chemello, Liliana, additional, Cavalletto, Luisa, additional, Morisco, Filomena, additional, Donnarumma, Laura, additional, Rumi, Maria Grazia, additional, Gasbarrini, Antonio, additional, Siciliano, Massimo, additional, Massari, Marco, additional, Corsini, Romina, additional, Coco, Barbara, additional, Madonia, Salvatore, additional, Cannizzaro, Marco, additional, Zignego, Anna Linda, additional, Monti, Monica, additional, Russo, Francesco Paolo, additional, Zanetto, Alberto, additional, Persico, Marcello, additional, Masarone, Mario, additional, Villa, Erica, additional, Bernabucci, Veronica, additional, Taliani, Gloria, additional, Biliotti, Elisa, additional, Chessa, Luchino, additional, Pasetto, Maria Cristina, additional, Andreone, Pietro, additional, Margotti, Marzia, additional, Brancaccio, Giuseppina, additional, Ieluzzi, Donatella, additional, Borgia, Guglielmo, additional, Zappulo, Emanuela, additional, Calvaruso, Vincenza, additional, Petta, Salvatore, additional, Falzano, Loredana, additional, Quaranta, Maria Giovanna, additional, Weimer, Liliana Elena, additional, Rosato, Stefano, additional, Vella, Stefano, additional, and Giannini, Edoardo Giovanni, additional

Published
2017
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49. Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network

Author

Kondili, Loreta A., Gaeta, Giovanni Battista, Brunetto, Maurizia Rossana, Di Leo, Alfredo, Iannone, Andrea, Santantonio, Teresa Antonia, Giammario, Adele, Raimondo, Giovanni, Filomia, Roberto, Coppola, Carmine, Amoruso, Daniela Caterina, Blanc, Pierluigi, Del Pin, Barbara, Chemello, Liliana, Cavalletto, Luisa, Morisco, Filomena, Donnarumma, Laura, Rumi, Maria Grazia, Gasbarrini, Antonio, Siciliano, Massimo, Massari, Marco, Corsini, Romina, Coco, Barbara, Madonia, Salvatore, Cannizzaro, Marco, Zignego, Anna Linda, Monti, Monica, Russo, Francesco Paolo, Zanetto, Alberto, Persico, Marcello, Masarone, Mario, Villa, Erica, Bernabucci, Veronica, Taliani, Gloria, Biliotti, Elisa, Chessa, Luchino, Pasetto, Maria Cristina, Andreone, Pietro, Margotti, Marzia, Brancaccio, Giuseppina, Ieluzzi, Donatella, Borgia, Guglielmo, Zappulo, Emanuela, Calvaruso, Vincenza, Petta, Salvatore, Falzano, Loredana, Quaranta, Maria Giovanna, Weimer, Liliana Elena, Rosato, Stefano, Vella, Stefano, Giannini, Edoardo Giovanni, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Kondili, Loreta A., Gaeta, Giovanni Battista, Brunetto, Maurizia Rossana, Di Leo, Alfredo, Iannone, Andrea, Santantonio, Teresa Antonia, Giammario, Adele, Raimondo, Giovanni, Filomia, Roberto, Coppola, Carmine, Amoruso, Daniela Caterina, Blanc, Pierluigi, Del Pin, Barbara, Chemello, Liliana, Cavalletto, Luisa, Morisco, Filomena, Donnarumma, Laura, Rumi, Maria Grazia, Gasbarrini, Antonio, Siciliano, Massimo, Massari, Marco, Corsini, Romina, Coco, Barbara, Madonia, Salvatore, Cannizzaro, Marco, Zignego, Anna Linda, Monti, Monica, Russo, Francesco Paolo, Zanetto, Alberto, Persico, Marcello, Masarone, Mario, Villa, Erica, Bernabucci, Veronica, Taliani, Gloria, Biliotti, Elisa, Chessa, Luchino, Pasetto, Maria Cristina, Andreone, Pietro, Margotti, Marzia, Brancaccio, Giuseppina, Ieluzzi, Donatella, Borgia, Guglielmo, Zappulo, Emanuela, Calvaruso, Vincenza, Petta, Salvatore, Falzano, Loredana, Quaranta, Maria Giovanna, Weimer, Liliana Elena, Rosato, Stefano, Vella, Stefano, Giannini, Edoardo Giovanni, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Background: Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure. Aim: To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage. Methods: Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers. Results: Among 3,830 patients with advanced fibrosis (F3) or cirrhosis, 139 (3.6%) failed to achieve SVR. Genotype 3, bilirubin levels >1.5mg/dl, platelet count <120,000/mm3 and the sofosbuvir+ribavirin regimen were independent predictors of failure by logistic regression analysis. The failure rate was 7.6% for patients treated with regimens that are no longer recommended or considered suboptimal (sofosbuvir+ribavirin or simeprevir+sofosbuvir±ribavirin), whereas 1.4% for regimens containing sofosbuvir combined with daclatasvir or ledipasvir or other DAAs. Of the patients who failed to achieve SVR, 72 (51.8%) were retreated with a second DAA regimen, specifically 38 (52.7%) with sofosbuvir+daclatasvir, 27 (37.5%) with sofosbuvir+ledipasvir, and 7 (9.7%) with other DAAs ±ribavirin. Among these, 69 (96%) patients achieved SVR12 and 3 (4%) failed. During a median time of 6 months (range: 5–14 months) between failure and the second DAA therapy, the Child-Pugh class worsened in 12 (16.7%) patients: from A to B in 10 patients (19.6%) and from B to C in 2 patients (10.5%), whereas it did not change in the remaining 60 patients. Following the retreatment SVR12 (median time of 6 months; range: 3–12 months), the Child-Pugh class improved in 17 (23.6%) patients: from B to A in 14 (19.4%) patients, from C to A in 1 patient (1.4%) and from C to B in 2 (2.9%) patients; it remained unchanged in 53 patients (73.6%)

Published
2017

50. Liver Angiopoietin‐2 Is a Key Predictor of De Novo or Recurrent Hepatocellular Cancer After Hepatitis C Virus Direct‐Acting Antivirals.

Author

Faillaci, Francesca, Marzi, Luca, Critelli, Rosina, Milosa, Fabiola, Schepis, Filippo, Turola, Elena, Andreani, Silvia, Vandelli, Gabriele, Bernabucci, Veronica, Lei, Barbara, D'Ambrosio, Federica, Bristot, Laura, Cavalletto, Luisa, Chemello, Liliana, Sighinolfi, Pamela, Manni, Paola, Maiorana, Antonino, Caporali, Cristian, Bianchini, Marcello, and Marsico, Maria

Published
2018
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