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2. An Email a Day Could Give Your Health Data Away

Author

Lange, Christof, Chang, Thomas, Fiedler, Maximilian, Petrlic, Ronald, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Garcia-Alfaro, Joaquin, editor, Navarro-Arribas, Guillermo, editor, and Dragoni, Nicola, editor

Published
2023
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4. RandNet: deep learning with compressed measurements of images

Author

Chang, Thomas, Tolooshams, Bahareh, and Ba, Demba

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Principal component analysis, dictionary learning, and auto-encoders are all unsupervised methods for learning representations from a large amount of training data. In all these methods, the higher the dimensions of the input data, the longer it takes to learn. We introduce a class of neural networks, termed RandNet, for learning representations using compressed random measurements of data of interest, such as images. RandNet extends the convolutional recurrent sparse auto-encoder architecture to dense networks and, more importantly, to the case when the input data are compressed random measurements of the original data. Compressing the input data makes it possible to fit a larger number of batches in memory during training. Moreover, in the case of sparse measurements,training is more efficient computationally. We demonstrate that, in unsupervised settings, RandNet performs dictionary learning using compressed data. In supervised settings, we show that RandNet can classify MNIST images with minimal loss in accuracy, despite being trained with random projections of the images that result in a 50% reduction in size. Overall, our results provide a general principled framework for training neural networks using compressed data., Comment: The first two authors contributed equally to this work

Published
2019

8. In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release.

Author

Ding, Ke, Celma, Cristina C, Zhang, Xing, Chang, Thomas, Shen, Wesley, Atanasov, Ivo, Roy, Polly, and Zhou, Z Hong

Subjects
Cell Line, Animals, Rotavirus, Capsid Proteins, RNA, Double-Stranded, RNA, Messenger, RNA, Viral, Cryoelectron Microscopy, Virus Replication, DNA Replication, Transcription, Genetic, Models, Molecular, Protein Domains, Chlorocebus aethiops, RNA-Dependent RNA Polymerase, Genetics, Infectious Diseases, 1.1 Normal biological development and functioning
Abstract

Transcribing and replicating a double-stranded genome require protein modules to unwind, transcribe/replicate nucleic acid substrates, and release products. Here we present in situ cryo-electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) in two states pertaining to transcription. In addition to the previously discovered universal "hand-shaped" polymerase core domain shared by DNA polymerases and telomerases, our results show the function of N- and C-terminal domains of RdRp: the former opens the genome duplex to isolate the template strand; the latter splits the emerging template-transcript hybrid, guides genome reannealing to form a transcription bubble, and opens a capsid shell protein (CSP) to release the transcript. These two "helicase" domains also extensively interact with CSP, which has a switchable N-terminal helix that, like cellular transcriptional factors, either inhibits or promotes RdRp activity. The in situ structures of RdRp, CSP, and RNA in action inform mechanisms of not only transcription, but also replication.

Published
2019

9. Next generation preservation solution using synthetic enzymes added to polyhemoglobin to protect warm ischemic human hepatocytes and cardiomyocytes.

Author

Hoq, Muntasirul and Chang, Thomas

Subjects
*SYNTHETIC enzymes, *BLOOD substitutes, *PRESERVATION of organs, tissues, etc., *CELL growth, *CELL culture
Abstract

This study investigates the potential improvement of polyhemoglobin's protective properties by the addition of 3 synthetic enzymes (neo-carbonic anhydrase, neo-catalase and neo-superoxide dismutase) to polyhemoglobin after 90 and 180 min of warm in-vitro ischemia (100% Nitrogen at 37 °C). Following the warm ischemic shock, cell cultures were subjected to various treatment solutions: Controls; PolyHb; 3 neoenzymes; PolyHb + 3 neoenzymes; PolyHb + 2 neoenzymes. The cultures were then incubated (Oxygen, 5% CO2 at 37 °C) for 24 h followed by several analyses. Compared to polyhemoglobin alone, this novel solution containing polyhemoglobin + 3 neoeznymes significantly increased the viability, cell growth, albumin production, protection against oxidative stress and cellular injury of human hepatocytes. Moreover, this also protects the viability of human cardiomyocytes. These findings suggest that it could be useful as a pre-transplant cell/organ preservation solution which, in the long-term, could contribute to the development of blood substitutes. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis

Author

Sichlau, Michael, Vlahos, Athanasios, Smith, Steven, Thalheimer, Quinn, Singh, Nisha, Harting, Rekha, Gocke, John, Guth, Scott, Shah, Neel, Brady, Paul, Schatz, Marvin, Horrow, Mindy, Markazi, Peyman, Forouzan, Leli, Matalon, Terence A.S., Hertzog, David, Goday, Swapna, Kennedy, Margaret, Kaplan, Robert, Campbell, Thomas, Hartman, Jamie, Nahum, Elmer, Venkat, Arvind, Krishnamurthy, Venkataramu, Rectenwald, John, Henke, Peter, Eliason, Jonathan, Willatt, Jonathon, Escobar, Guillermo, Samuels, Shaun, Katzen, Barry, Benenati, James, Powell, Alex, Pena, Constantino, Wallach, Howard, Gandhi, Ripal, Schneider, Joseph, Kim, Stanley, Hashemi, Farrah, Boyle, Joseph, Patel, Nilesh, Verta, Michael, Leung, Daniel, Garcia, Marc, Blatt, Phillip, Khatri, Jamil, Epstein, Dave, Ryan, Randall, Sweeny, Tom, Stillabower, Michael, Kimbiris, George, Raman, Tuhina, Sierzenski, Paul, Getto, Lelia, Dignazio, Michael, Horvath, Mark, Gornik, Heather, Bartholomew, John, Shishehbor, Mehdi, Peacock, Frank, Joseph, Douglas, Kim, Soo Hyum, Mahlay, Natalia Fendrikova, Clair, Daniel, Lyden, Sean, Kapoor, Baljendra, McLennon, Gordon, Pierce, Gregory, Newman, James, Spain, James, Gill, Amanjiit, Hamilton, Aaron, Rizzo, Anthony, Park, Woosup, Dietzek, Alan, Galin, Ira, Plummer, Dahlia, Hsu, Richard, Broderick, Patrick, Keller, Andrew, Sayeed, Sameer, Slater, Dennis, Lustberg, Herb, Akus, Jan, Sidman, Robert, Dhami, Mandeep, Kohanski, Phillip, Bulgaru, Anca, Dulala, Renuka, Burch, James, Kapur, Dinesh, Yang, Jie, Ranson, Mark, Wladis, Alan, Varnagy, David, Mekhail, Tarek, Winter, Robert, Perez-Izquierdo, Manuel, Motew, Stephen, Royd-Kranis, Robin, Workman, Raymond, Kribbs, Scott, Hogsette, Gerald, Moore, Phillip, Thomason, Bradley, Means, William, Bonsall, Richard, Stewart, John, Golwya, Daniel, Azene, Ezana, Bottner, Wayne, Bishop, William, Clayton, Dave, Gundersen, Lincoln, Riherd, Jody, Shakhnovich, Irina, Ziegelbein, Kurt, Chang, Thomas, Sharma, Karun, Allison, Sandra, Banovac, Fil, Cohen, Emil, Furlong, Brendan, Kessler, Craig, McCullough, Mike, Spies, Jim, Lin, Judith, Kaatz, Scott, Getzen, Todd, Miller, Joseph, Schwartz, Scott, Kabbani, Loay, McVinnie, David, Rundback, John, Manno, Joseph, Schwab, Richard, Cole, Randolph, Herman, Kevin, Singh, David, Barkama, Ravit, Patel, Amish, Comerota, Anthony, Pigott, John, Seiwert, Andrew, Whalen, Ralph, Russell, Todd, Assi, Zakaria, Kazanjian, Sahira, Yobbagy, Jonathan, Kaminski, Brian, Kaufman, Allan, Begeman, Garett, DiSalle, Robert, Thakur, Subash, Kim, Paul, Jacquet, Marc, Dykes, Thomas, Gerding, Joseph, Baker, Christopher, Debiasto, Mark, Mittleider, Derek, Higgins, George, III, Amberson, Steven, Pezzuti, Roger, Gallagher, Thomas, Schainfeld, Robert, Wicky, Stephan, Kalva, Sanjeeva, Walker, Gregory, Salazar, Gloria, Pomerantz, Benjamin, Patel, Virenda, Kabrhel, Christopher, Iqbal, Shams, Gangull, Suvranu, Oklu, Rahmi, Brannan, Scott, Misra, Sanjay, Bjarnason, Haraldur, Ashrani, Aneel, Caccavale, Michael, Fleming, Chad, Friese, Jeremy, Heit, John, Kalra, Manju, Macedo, Thanila, McBane, Robert, McKusick, Michael, Stockland, Andrew, Woodrum, David, Wysokinski, Waldemar, Verma, Adarsh, Davis, Andrew, Chung, Jerry, Nicker, David, Anderson, Brian, Stein, Robert, Weiss, Michael, Patel, Parag, Rilling, William, Tutton, Sean, Hieb, Robert, Hohenwalter, Eric, Colella, M. Riccardo, Gosset, James, White, Sarah, Lewis, Brian, Brown, Kellie, Rossi, Peter, Seabrook, Gary, Guimaraes, Marcelo, Selby, J. Bayne, McGary, William, Hannegan, Christopher, Robison, Jacob, Brothers, Thomas, Elliott, Bruce, Garg, Nitin, Anderson, M. Bret, Uflacker, Renan, Schonholz, Claudio, Raney, Laurence, Greenberg, Charles, Kaufman, John, Keller, Frederick, Kolbeck, Kenneth, Landry, Gregory, Mitchell, Erica, Barton, Robert, DeLoughery, Thomas, Kalbfleisch, Norman, Minjarez, Renee, Lakin, Paul, Liem, Timothy, Moneta, Gregory, Farsad, Khashayar, Fleischman, Ross, French, Loren, Marques, Vasco, Al−Hassani, Yasir, Sawar, Asad, Taylor, Frank, Patel, Rajul, Malhotra, Rahul, Hashemi, Farah, Padnick, Marvin, Gurley, Melissa, Cucher, Fred, Sterrenberg, Ronald, Deepthi, G. Reshmaal, Cumaranatunge, Gomes, Bhatla, Sumit, Jacobs, Darick, Dolen, Eric, Gamboa, Pablo, Dean, L. Mark, Davis, Thomas, Lippert, John, Khanna, Sanjeev, Schirf, Brian, Silber, Jeffrey, Wood, Donald, McGraw, J. Kevin, LaPerna, Lucy, Willette, Paul, Murphy, Timothy, Cerezo, Joselyn, Dhangana, Rajoo, Ahn, Sun Ho, Dubel, Gregory, Haas, Richard, Jay, Bryan, Prince, Ethan, Soares, Gregory, Klinger, James, Lambiase, Robert, Jay, Gregory, Tubbs, Robert, Beland, Michael, Hampson, Chris, O'Hara, Ryan, Thompson, Chad, Frodsham, Aaron, Gardiner, Fenwick, Jaffan, Abdel, Keating, Lawrence, Zafar, Abdul, Alicic, Radica, Raabe, Rodney, Brower, Jayson, McClellan, David, Pellow, Thomas, Zylak, Christopher, Davis, Joseph, Reilly, M. Kathleen, Symington, Kenneth, Seibold, Camerson, Nachreiner, Ryan, Murray, Daniel, Murray, Stephen, Saha, Sandeep, Luna, Gregory, Hodgson, Kim, McLafferty, Robert, Hood, Douglas, Moore, Colleen, Griffen, David, Hurst, Darren, Lubbers, David, Kim, Daniel, Warren, Brent, Engel, Jeremy, Suresh, D.P., VanderWoude, Eric, Razdan, Rahul, Hutchins, Mark, Rounsborg, Terry, Midathada, Madhu, Moravec, Daniel, Tilford, Joni, Beckman, Joni, Razavi, Mahmood, Openshaw, Kurt, Flanigan, D. Preston, Loh, Christopher, Dorne, Howard, Chan, Michael, Thomas, Jamie, Psaila, Justin, Ringold, Michael, Fisher, Jay, Lipcomb, Any, Oskin, Timothy, Wible, Brandt, Coleman, Brendan, Elliott, David, Gaddis, Gary, Cochran, C. Doug, Natarajan, Kannan, Bick, Stewart, Cooke, Jeffrey, Hedderman, Ann, Greist, Anne, Miller, Lorrie, Martinez, Brandon, Flanders, Vincent, Underhill, Mark, Hofmann, Lawrence, Sze, Daniel, Kuo, William, Louie, John, Hwang, Gloria, Hovsepian, David, Kothary, Nishita, Berube, Caroline, Schreiber, Donald, Jeffrey, Brooke, Schor, Jonathan, Deitch, Jonathan, Singh, Kuldeep, Hahn, Barry, Ardolic, Brahim, Gupta, Shilip, Bashir, Riyaz, Rao, Angara Koneti, Garg, Manish, Patil, Pravin, Zack, Chad, Cohen, Gary, Schmieder, Frank, Lakhter, Valdimir, Sacks, David, Guay, Robert, Scott, Mark, Cunningham, Karekin, Sigal, Adam, Cescon, Terrence, Leasure, Nick, Dhurairaj, Thiruvenkatasamy, Muck, Patrick, Knochel, Kurt, Lohr, Joann, Barreau, Jose, Recht, Matthew, Bhaskaran, Jayapandia, Brahmamdam, Ranga, Draper, David, Mehta, Apurva, Maher, James, Sharafuddin, Melhem, Lentz, Steven, Nugent, Andrew, Sharp, William, Kresowik, Timothy, Nicholson, Rachel, Sun, Shiliang, Youness, Fadi, Pascarella, Luigi, Ray, Charles, Knuttinen, Martha-Gracia, Bui, James, Gaba, Ron, Dobiesz, Valerie, Shamim, Ejaz, Nimmagadda, Sangeetha, Peace, David, Zain, Aarti, Palumto, Alison, Haskal, Ziv, Hirshon, Jon Mark, Richard, Howard, Verceles, Avelino, Wong-You-Chong, Jade, Othee, Bertrand, Patel, Rahul, Iliescu, Bogdan, Williams, David, Gemmete, Joseph, Cwikiel, Wojciech, Cho, Kyung, Schields, James, Vellody, Ranjith, Novelli, Paula, Dasika, Narasimham, Wakefield, Thomas, Desmond, Jeffrey, Froehlich, James, Khaja, Minhajuddin, Hunter, David, Golzarian, Jafar, Cressman, Erik, Dotta, Yvonne, Schmiechen, Nate, Marek, John, Garcia, David, Tawil, Isaac, Langsfeld, Mark, Moll, Stephan, Mauro, Matthew, Stavas, Joseph, Burke, Charles, Dixon, Robert, Yu, Hyeon, Keagy, Blair, Kim, Kyuny, Kasthuri, Raj, Key, Nigel, Chaer, Rabih, Makaroun, Michael, Rhee, Robert, Cho, Jae−Sung, Baril, Donald, Marone, Luke, Hseih, Margaret, Feterik, Kristian, Smith, Roy, Jeyabalan, Geetha, Rogers, Jennifer, Vinik, Russel, Kinikini, Dan, Kraiss, Larry, Mueller, Michelle, Pendleton, Robert, Rondina, Matthew, Sarfati, Mark, Wanner, Nathan, Johnson, Stacy, Hopkins, Christy, Ihnat, Daniel, Angle, John, Matsumoto, Alan, Harthun, Nancy, Turba, Ulku, Saad, Wael, Uthlaut, Brian, Nannapaneni, Srikant, Ling, David, Sabri, Saher, Kern, John, Macik, B. Gail, Hoke, George, Park, Auh Wahn, Stone, James, Sneed, Benjamin, Syverud, Scott, Davidson, Kelly, Sharma, Aditya, Wilkins, Luke, Black, Carl, Asay, Mark, Hatch, Daniel, Smilanich, Robert, Patten, Craig, Brown, S. Douglas, Nielsen, Ryan, Alward, William, Collins, John, Nokes, Matthew, Geary, Randolph, Edwards, Matthew, Godshall, Christopher, Levy, Pavel, Winokur, Ronald, Sista, Akhilesh, Madoff, David, Lee, Kyungmouk, Pua, Bradley, DeSancho, Maria, Milizia, Raffaele, Gao, Jing, McLean, Gordon, Khalid, Sanualah, Vedantham, Suresh, Lewis, Larry, Saad, Nael, Thoelke, Mark, Pallow, Robert, Klein, Seth, Sicard, Gregorio, Cohen, David J., Comerota, Anthony J., Gornik, Heather L., Jaff, Michael R., Julian, Jim, Kahn, Susan R., Kearon, Clive, Kee, Stephen, Kindzelski, Andrei L., Lewis, Lawrence, Magnuson, Elizabeth, Razavi, Mahmood K., Murphy, Timothy P., Julian, Jim A., Gu, Chu-Shu, Magnuson, Elizabeth A., Goldhaber, Samuel Z., Schneider, Joseph R., Sista, Akhilesh K., McLafferty, Robert B., Kaufman, John A., Wible, Brandt C., and Blinder, Morey

Published
2020
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40. Neuromas

Author

Chang, Thomas J., Lee, Michael S., editor, and Grossman, Jordan P., editor

Published
2017
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44. Superparamagnetic Artificial Cells PLGA-Fe 3 O 4 Micro/Nanocapsules for Cancer Targeted Delivery.

Author

Wang, Tao and Chang, Thomas Ming Swi

Subjects
*DRUG delivery systems, *FEVER, *THERMOTHERAPY, *PHOTOTHERAPY, *SPRAY drying, *DRUG design, *METASTASIS, *MICROFLUIDIC analytical techniques, *IRON oxide nanoparticles, *NANOPARTICLES
Abstract

Simple Summary: Cancer is the main cause of human death. Nanomedicine provides a new strategy for the treatment of diverse cancers. Among them, superparamagnetic artificial cell PLGA-Fe3O4 micro/nanocapsules demand great attention due to their excellent properties, such as targeted delivery, magnetic response, and biocompatibility. The aim of this review is to summarize the application of superparamagnetic artificial cells (PLGA-Fe3O4) micro/nanocapsules in cancer drug targeted delivery and their preparation methods, providing insights into the future development of superparamagnetic artificial cells (PLGA nano/microcapsules) for magnetic targeting in cancer treatment. Artificial cells have been extensively used in many fields, such as nanomedicine, biotherapy, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, and the COVID-19 vaccine. The unique properties of superparamagnetic Fe3O4 nanoparticles have contributed to increased interest in using superparamagnetic artificial cells (PLGA-Fe3O4 micro/nanocapsules) for targeted therapy. In this review, the preparation methods of Fe3O4 NPs and superparamagnetic artificial cell PLGA-drug-Fe3O4 micro/nanocapsules are discussed. This review also focuses on the recent progress of superparamagnetic PLGA-drug-Fe3O4 micro/nanocapsules as targeted therapeutics. We shall concentrate on the use of superparamagnetic artificial cells in the form of PLGA-drug-Fe3O4 nanocapsules for magnetic hyperthermia/photothermal therapy and cancer therapies, including lung breast cancer and glioblastoma. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Prospective Multicenter Diagnostic Performance of Technologist-Performed Screening Breast Ultrasound After Tomosynthesis in Women With Dense Breasts (the DBTUST)

Author

Berg, Wendie A., primary, Zuley, Margarita L., additional, Chang, Thomas S., additional, Gizienski, Terri-Ann, additional, Chough, Denise M., additional, Böhm-Vélez, Marcela, additional, Sharek, Danielle E., additional, Straka, Michelle R., additional, Hakim, Christiane M., additional, Hartman, Jamie Y., additional, Harnist, Kimberly S., additional, Tyma, Cathy S., additional, Kelly, Amy E., additional, Waheed, Uzma, additional, Houshmand, Golbahar, additional, Nair, Bronwyn E., additional, Shinde, Dilip D., additional, Lu, Amy H., additional, Bandos, Andriy I., additional, Berg, Jeremy M., additional, Lettiere, Nicole B., additional, and Ganott, Marie A., additional

Published
2023
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49. Figure S3 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Author

Charych, Deborah H., primary, Hoch, Ute, primary, Langowski, John L., primary, Lee, Steve R., primary, Addepalli, Murali K., primary, Kirk, Peter B., primary, Sheng, Dawei, primary, Liu, Xiaofeng, primary, Sims, Paul W., primary, VanderVeen, Laurie A., primary, Ali, Cherie F., primary, Chang, Thomas K., primary, Konakova, Marina, primary, Pena, Rhoneil L., primary, Kanhere, Rupesh S., primary, Kirksey, Yolanda M., primary, Ji, Chunmei, primary, Wang, Yujun, primary, Huang, Jicai, primary, Sweeney, Theresa D., primary, Kantak, Seema S., primary, and Doberstein, Stephen K., primary

Published
2023
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50. Supplemental Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Author

Charych, Deborah H., primary, Hoch, Ute, primary, Langowski, John L., primary, Lee, Steve R., primary, Addepalli, Murali K., primary, Kirk, Peter B., primary, Sheng, Dawei, primary, Liu, Xiaofeng, primary, Sims, Paul W., primary, VanderVeen, Laurie A., primary, Ali, Cherie F., primary, Chang, Thomas K., primary, Konakova, Marina, primary, Pena, Rhoneil L., primary, Kanhere, Rupesh S., primary, Kirksey, Yolanda M., primary, Ji, Chunmei, primary, Wang, Yujun, primary, Huang, Jicai, primary, Sweeney, Theresa D., primary, Kantak, Seema S., primary, and Doberstein, Stephen K., primary

Published
2023
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