Search

Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment’s high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay $Q$ value.

Background: Previous studies have reported that acupuncture combined Bobath approach (BA) can be used to treat limbs paralysis (LP) after hypertensive intracerebral hemorrhage (HICH) effectively. However, no systematic review has explored its effectiveness and safety for LP following HICH. In this systematic review, we aim to assess the effectiveness and safety of acupuncture plus BA for the treatment of LP following HICH. Methods: The following 7 databases will be searched from their inception to the February 1, 2019: Cochrane Central Register of Controlled Trials, EMBASE, PUBMED, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure without any language restrictions. The randomized controlled trials (RCTs) of acupuncture plus BA that evaluate the effectiveness and safety for LP after HICH will be included. The methodological quality of all included studies will be assessed by using Cochrane risk of bias tool. Two authors will independently perform study selection, data extraction, and methodological quality evaluation. Any disagreements occurred between 2 authors will be resolved by a third author involved through discussion. Data will be pooled and analyzed by using RevMan 5.3 Software. Results: This review will evaluate the effectiveness and safety of acupuncture combined BA for LP following HICH. The primary outcome is limbs function. The secondary outcomes are muscle strength, muscle tone, and quality of life, as well as the adverse events. Conclusion: The results of this study will summarize the latest evidence of acupuncture combined BA for LP following HICH.

Author(s): Haufe, CR; Reine, AL; Abgrall, N; Alvis, SI; Arnquist, IJ; Avignone, FT; Barabash, AS; Barton, CJ; Bertrand, FE; Bode, T; Bradley, AW; Brudanin, V; Busch, M; Buuck, M; Caldwell, TS; Chan, YD; Christofferson, CD; Chu, PH; Cuesta, C; Detwiler, JA; Dunagan, C; Efremenko, Y; Ejiri, H; Elliott, SR; Gilliss, T; Giovanetti, GK; Green, MP; Gruszko, J; Guinn, IS; Guiseppe, VE; Hehn, L; Henning, R; Hoppe, EW; Howe, MA; Keeter, KJ; Kidd, MF; Konovalov, SI; Kouzes, RT; Lopez, AM; Martin, RD; Massarczyk, R; Meijer, SJ; Mertens, S; Myslik, J; O'Shaughnessy, C; Othman, G; Pettus, W; Poon, AWP; Radford, DC; Rager, J; Rielage, K; Robertson, RGH; Ruof, NW; Shanks, B; Shirchenko, M; Suriano, AM; Tedeschi, D; Trimble, JE; Varner, RL; Vasilyev, S; Vetter, K; Vorren, K; White, BR; Wilkerson, JF; Wiseman, C; Xu, W; Yakushev, E; Yu, CH; Yumatov, V; Zhitnikov, I; Zhu, BX | Abstract: The MAJORANA DEMONSTRATOR is an experiment constructed to search for neutrinoless double-beta decays in germanium-76 and to demonstrate the feasibility to deploy a ton-scale experiment in a phased and modular fashion. It consists of two modular arrays of natural and 76Ge-enriched germanium p-Type point contact detectors totaling 44.1 kg, located at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. The DEMONSTRATOR uses custom high voltage cables to bias the detectors, as well as custom signal cables and connectors to read out the charge deposited at each detectors point contact. These low-mass cables and connectors must meet stringent radiopurity requirements while being subjected to thermal and mechanical stress. A number of issues have been identified with the currently installed cables and connectors. An improved set of cables and connectors for the MAJORANA DEMONSTRATOR are being developed with the aim of increasing their overall reliability and connectivity. We will discuss some of the issues encountered with the current cables and connectors as well as our improved designs and their initial performance.

The MAJORANA DEMONSTRATOR is an experiment constructed to search for neutrinoless double-beta decay in $^{76}$Ge and to demonstrate the feasibility to deploy a large-scale experiment in a phased and modular fashion. It consists of two modules of natural and $^{76}$Ge-enriched germanium detectors totalling 44.1 kg, operating at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. Commissioning of the experiment began in June 2015, followed by data production with the full detector array in August 2016. The ultra-low background and record energy resolution achieved by the MAJORANA DEMONSTRATOR enable a sensitive neutrinoless double-beta decay search, as well as additional searches for physics beyond the Standard Model. I will discuss the design elements that enable these searches, along with the latest results, focusing on the neutrinoless double-beta decay search. I will also discuss the current status and the future plans of the MAJORANA DEMONSTRATOR, as well as the plans for a future tonne-scale $^{76}$Ge experiment., 4 pages. Proceedings of The 39th International Conference on High Energy Physics (ICHEP2018), 4-11 July, 2018, Seoul, Korea. Submitted to Proceedings of Science

The MAJORANA Collaboration is searching for the neutrinoless double-beta decay of the nucleus Ge-76. The MAJORANA DEMONSTRATOR is an array of germanium detectors deployed with the aim of implementing background reduction techniques suitable for a tonne scale Ge-76-based search (the LEGEND collaboration). In the DEMONSTRATOR, germanium detectors operate in an ultra-pure vacuum cryostat at 80 K. One special challenge of an ultra-pure environment is to develop reliable cables, connectors, and electronics that do not significantly contribute to the radioactive background of the experiment. This paper highlights the experimental requirements and how these requirements were met for the MAJORANA DEMONSTRATOR, including plans to upgrade the wiring for higher reliability in the summer of 2018. Also described are requirements for LEGEND R&D efforts underway to meet these additional requirements., Proceedings of LRT 2017

Myeloid differentiation factor 88 (MyD88) is an adapter protein involved in the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR)-mediated activation of nuclear factor-kappaB (NF-κB). In this study, a full length cDNA of MyD88 was cloned from turbot, Scophthalmus maximus. It is 1619 bp in length and contains an 858-bp open reading frame that encodes a peptide of 285 amino acid residues. The putative turbot (Sm)MyD88 protein possesses a N-terminal death domain and a C-terminal Toll/IL-1 receptor (TIR) domain known to be important for the functions of MyD88 in mammals. Phylogenetic analysis grouped SmMyD88 with other fish MyD88s. SmMyD88 mRNA was ubiquitously expressed in all examined tissues of healthy turbots, with higher levels observed in immune-relevant organs. To explore the role of SmMyD88, its gene expression profile in response to stimulation of lipopolysaccharide (LPS), CpG oligodeoxynucleotide (CpG-ODN) or turbot reddish body iridovirus (TRBIV) was studied in the head kidney, spleen, gills and muscle over a 7-day time course. The results showed an up-regulation of SmMyD88 transcript levels by the three immunostimulants in all four examined tissues, with the induction by CpG-ODN strongest and initiated earliest and inducibility in the muscle very weak. Additionally, TRBIV challenge resulted in a quite high level of SmMyD88 expression in the spleen, whereas the two synthetic immunostimulants induced the higher levels in the head kidney. These data provide insights into the roles of SmMyD88 in the TLR/IL-1R signaling pathway of the innate immune system in turbot.

High purity germanium (HPGe) crystals will be used for the MAJORANA DEMONSTRATOR, where they serve as both the source and the detector for neutrinoless double beta decay. It is crucial for the experiment to understand the performance of the HPGe crystals. A variety of crystal properties are being investigated, including basic properties such as energy resolution, efficiency, uniformity, capacitance, leakage current and crystal axis orientation, as well as more sophisticated properties, e.g. pulse shapes and dead layer and transition layer distributions. In this paper, we will present our measurements that characterize the HPGe crystals. We will also discuss our simulation package for the detector characterization setup, and show that additional information can be extracted from data-simulation comparisons., Comment: To appear in the Proceedings of the 13th International Conference on Topics in Astroparticle and Underground Physics, TAUP 2013 (F. Avignone & W. Haxton, editors, Physics Procedia, Elsevier)

Neutrinoless double-beta decay searches play a major role in determining the nature of neutrinos, the existence of a lepton violating process, and the effective Majorana neutrino mass. The MAJORANA Collaboration assembled an array of high purity Ge detectors to search for neutrinoless double-beta decay in Ge-76. The MAJORANA DEMONSTRATOR is comprised of 44.1 kg (29.7 kg enriched in Ge-76) of Ge detectors divided between two modules contained in a low-background shield at the Sanford Underground Research Facility in Lead, South Dakota, USA. The initial goals of the DEMONSTRATOR are to establish the required background and scalability of a Ge-based next-generation ton-scale experiment. Following a commissioning run that started in 2015, the first detector module started low-background data production in early 2016. The second detector module was added in August 2016 to begin operation of the entire array. We discuss results of the initial physics runs, as well as the status and physics reach of the full MAJORANA DEMONSTRATOR experiment., Proceedings of the MEDEX'17 meeting (Prague, May 29 - June 2, 2017)

Electromagnetic properties of atomic nuclei such as $E2$ transition rates and $M1$ magnetic moments (or $g$ factors) are crucial characteristics of structure. For unstable nuclei produced as reaccelerated radioactive beams, measurements of $g$ factors present numerous challenges. This paper develops the important recoil-in-vacuum technique to obtain a $g$ factor for the ${2}^{+}$ state in ${}^{136}$Te. The result fits existing systematics but also highlights anomalous values in other $N=84$ isotones, thus presenting an important challenge to theory in the region just above doubly magic ${}^{132}$Sn.

A search for Pauli-exclusion-principle-violating K-alpha electron transitions was performed using 89.5 kg-d of data collected with a p-type point contact high-purity germanium detector operated at the Kimballton Underground Research Facility. A lower limit on the transition lifetime of 5.8x10^30 seconds at 90% C.L. was set by looking for a peak at 10.6 keV resulting from the x-ray and Auger electrons present following the transition. A similar analysis was done to look for the decay of atomic K-shell electrons into neutrinos, resulting in a lower limit of 6.8x10^30 seconds at 90 C.L. It is estimated that the MAJORANA DEMONSTRATOR, a 44 kg array of p-type point contact detectors that will search for the neutrinoless double-beta decay of 76-Ge, could improve upon these exclusion limits by an order of magnitude after three years of operation. Abgrall, N; Arnquist, I J; Avignone, F T; Barabash, A S; Bertrand, F E; Bradley, A W; Brudanin, V; Busch, M; Buuck, M; Caldwell, A S; Chan, Y-D; Christofferson, C D; Chu, P -H; Cuesta, C; Detwiler, J A; Dunagan, C; Efremenko, Yu; Ejiri, H; Elliott, S R; Finnerty, P S; Galindo-Uribarri, A; Gilliss, T; Giovanetti, G K; Goett, J; Green, M P; Gruszko, J; Guinn, I S; Guiseppe, V E; Henning, R; Hoppe, E W; Howard, S; Howe, M A; Jasinski, B R; Keeter, K J; Kidd, M F; Konovalov, S I; Kouzes, R T; LaFerriere, B D; Leon, J; MacMullin, J; Martin, R D; Massarczyk, R; Meijer, S J; Mertens, S; Orrell, J L; O'Shaughnessy, C; Poon, A W P; Radford, D C; Rager, J; Rielage, K; Robertson, R G H; Romero-Romero, E; Shanks, B; Shirchenko, M; Suriano, A M; Tedeschi, D; Trimble, J E; Varner, R L; Vasilyev, S; Vetter, K; Vorren, K; White, B R; Wilkerson, J F; Wiseman, C; Xu, W; Yakushev, E; Yu, C -H; Yumatov, V; Zhitnikov, I

A complete set of electromagnetic moments, B(E2;0+1 2+1), Q(2+1), and g(2+1), have been measured from Coulomb excitation of semi-magic 112,114,116,118,120,122,124Sn (Z = 50) on natural carbon and titanium targets. The magnitude of the B(E2) values, measured to a precision of ~4%, disagree with a recent lifetime study [Phys. Lett. B 695, 110 (2011)] that employed the Doppler- shift attenuation method. The B(E2) values show an overall enhancement compared with recent theoretical calculations and a clear asymmetry about midshell, contrary to naive expectations. A new static electric quadrupole moment, Q(2+1), has been measured for 114Sn. The static quadrupole moments are generally consistent with zero but reveal an enhancement near midshell; this had not been previously observed. The magnetic dipole moments are consistent with previous measurements and show a near monotonic decrease in value with neutron number. The current theory calculations fail to reproduce the electromagnetic moments of the tin isotopes. The role of 2p-2h and 4p-4h intruders, which are lowest in energy at mid shell and outside of current model spaces, needs to be investigated in the future.

The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, modular, HPGe detector array with a mass of 44-kg (29 kg 76Ge and 15 kg natGe) to search for neutrinoless double beta decay in Ge-76. The next generation of tonne-scale Ge-based neutrinoless double beta decay searches will probe the neutrino mass scale in the inverted-hierarchy region. The MAJORANA DEMONSTRATOR is envisioned to demonstrate a path forward to achieve a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value of 2039 keV. The MAJORANA DEMONSTRATOR follows a modular implementation to be easily scalable to the next generation experiment. First, the prototype module was assembled; it has been continuously taking data from July 2014 to June 2015. Second, Module 1 with more than half of the total enriched detectors and some natural detectors has been assembled and it is being commissioned. Finally, the assembly of Module 2, which will complete MAJORANA DEMONSTRATOR, is already in progress., Comment: 4 pages, 3 figures

The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, 40-kg modular HPGe detector array to search for neutrinoless double beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based 0nbb-decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the MAJORANA DEMONSTRATOR is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The background rejection techniques to be applied to the data include cuts based on data reduction, pulse shape analysis, event coincidences, and time correlations. The Point Contact design of the DEMONSTRATOR 0s germanium detectors allows for significant reduction of gamma background., 4 pages, 2 figures