19 results on '"Cengiz Cem"'
Search Results
2. Recent advances in endoscopic management of gastric neoplasms
- Author
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Tharian, Benjamin, Garcia-Saenz-de-Sicilia, Mauricio, İnamdar, Sumant, Cheema, Hira Imad, Cengiz, Cem, Tharian, Benjamin, Garcia-Saenz-de-Sicilia, Mauricio, İnamdar, Sumant, Cheema, Hira Imad, and Cengiz, Cem
- Abstract
The development and clinical application of new diagnostic endoscopic technologies such as endoscopic ultrasonography with biopsy, magnification endoscopy, and narrow-band imaging, more recently supplemented by artificial intelligence, have enabled wider recognition and detection of various gastric neoplasms including early gastric cancer (EGC) and subepithelial tumors, such as gastrointestinal stromal tumors and neuroendocrine tumors. Over the last decade, the evolution of novel advanced therapeutic endoscopic techniques, such as endoscopic mucosal resection, endoscopic submucosal dissection, endoscopic full-thickness resection, and submucosal tunneling endoscopic resection, along with the advent of a broad array of endoscopic accessories, has provided a promising and yet less invasive strategy for treating gastric neoplasms with the advantage of a reduced need for gastric surgery. Thus, the management algorithms of various gastric tumors in a defined subset of the patient population at low risk of lymph node metastasis and amenable to endoscopic resection, may require revision considering upcoming data given the high success rate of en bloc resection by experienced endoscopists. Moreover, endoscopic surveillance protocols for precancerous gastric lesions will continue to be refined by systematic reviews and meta-analyses of further research. However, the lack of familiarity with subtle endoscopic changes associated with EGC, as well as longer procedural time, evolving resection techniques and tools, a steep learning curve of such high-risk procedures, and lack of coding are issues that do not appeal to many gastroenterologists in the field. This review summarizes recent advances in the endoscopic management of gastric neoplasms, with special emphasis on diagnostic and therapeutic methods and their future prospects.
- Published
- 2023
3. Resection of subepithelial lesions by a novel technique: “Band endoscopic full-thickness resection”
- Author
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Cheema, Hira, additional, Raghavapuram, Saikiran, additional, Boston, Iman, additional, Cengiz, Cem, additional, Anastasiou, Jiannis, additional, Inamdar, Sumant, additional, and Tharian, Benjamin, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Demir eksikliği anemisi ve dispepsinin nadir bir nedeni: Duodenumda dev Brunner gland hamartomu (Brunneroma)
- Author
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Cengiz, Cem and Cengiz, Cem
- Abstract
Brunner gland hamartomu duodenumdaki Brunner bezlerinden köken alan, düz kas ve yağ dokusunun da eşlik edebildiği nadir benign tümörlerdir. Kü- çük boyutlarda iken asemptomatiktirler. Ancak zamanla büyük boyutlara ulaşıp sıklıkla gastrik çıkış obtrüksiyonu, duodenal obstrüksiyon veya gast- rointestinal hemorajiye neden olabilirler. Melena veya sadece demir eksikliği anemisi görülebilir., A Brunner's gland hamartoma is a rare benign tumor originating from Brun- ner's glands of the duodenum, also including smooth muscles and adipose tissues. It is asymptomatic when small; however, it may lead to a gastric outlet obstruction, a duodenal obstruction, or a gastrointestinal hemorrhage when it reaches a larger size over time. A melena or only an iron deficiency anemia may be seen.
- Published
- 2021
5. Siroz ve Sarkopeni
- Author
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Cengiz, Cem, TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, TOBB ETU, Faculty of Medicine, Department of Internal Medical Sciences, and Cengiz, Cem
- Subjects
siroz ,sarkopeni - Abstract
[No abstract availeble]
- Published
- 2019
6. Gastrointestinal Hemorrhage And Its Management In Geriatric Age Group
- Author
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Cengiz, Cem and Oğuz, Dilek
- Subjects
Cerrahi - Abstract
Approximately 35%-40% of geriatric patients seek medical care for gastrointestinal symptoms at least once a year. At least 1% of the population aged over 80 years is hospitalized each year due to gastrointestinal hemorrhage. Gastrointestinal hemorrhage is frequently observed in this population and associated with high mortality and morbidity. Also, gastrointestinal hemorrhage is one of the main causes of hospitalization among geriatric patients. Geriatric patients with GIH constitute a subgroup of patients requiring special care in hospitals. The bleeding may occur in the upper or lower gastrointestinal tract and manifest itself with a variety of symptoms depending on its location. The incidence and natural course of hemorrhage are affected by antiplatelet and anticoagulant medications. The outcome of gastrointestinal hemorrhage in geriatric patients depends largely on the characteristics of bleeding lesion and comorbidities. Geriatri yaş grubundaki hastaların yaklaşık %35-40’lık bir kısmı, yılda en az 1 kez gastrointestinal semptomlar nedeni ile tıbbi yardıma ihtiyaç duymaktadır. Seksen yaş üstü nüfusun en az %1’i, her yıl gastrointestinal kanama nedeni ile hastaneye yatmak zorunda kalmaktadır. Gastrointestinal kanaması olan geriatric olgular, hastanelerde özel bakım gerektiren hasta grubunu oluşturmaktadır. Geriatrik çağda gastrointestinal kanama sık gözlenmektedir ve beraberinde yüksek morbidite ve mortalite riski taşımaktadır. Kanama üst veya alt gastrointestinal sistemden köken alabilir ve kanama lokalizasyonuna göre semptom çeşitliliği gösterebilmektedir. Kanamanın insidansı ve klinik seyri, hastanın kullandığı antiplatellet veya antikoagülan tedaviden etkilenmektedir. Geriatrik olgulardaki kanamanın seyri çoğunlukla kanayan lezyonun karakteristiğine ve eşlik eden hastalık olup olmamasına bağlıdır.
- Published
- 2019
7. Nerve-glial antigen 2: A novel target for anti-tumor therapy in colorectal cancer
- Author
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Kuzu, M. Ayhan, Boyacıoğlu, A. Sedat, Bulut, Şafak, Cengiz, Cem, Kuzu, M. Ayhan, Boyacıoğlu, A. Sedat, Bulut, Şafak, and Cengiz, Cem
- Abstract
Background/Aims: To identify cell surface markers selectively expressed by tumor cells and tumor vasculature is the current goal for tumor therapy. One such marker is nerve/glial antigen 2 (NG2), which is a transmembrane glycoprotein. We aimed to investigate the expression of NG2 in colorectal cancer (CRC) and its association with clinicopathological parameters. Methods: Immunohistochemical staining of NG2, vascular endothelial growth factor, and CD34 in 65 patients diagnosed with CRC over a 5-year period was performed. NG2 expression in both tumor cells and tumor vasculature was scored according to the German Reactive Scoring System. The association between NG2 and patient and tumor characteristics was analyzed. Results: NG2 was expressed by tumor cells in 56.9%, tumor vasculature in 43%, and simultaneously by both in 27.6% of the cases. Tumor cell NG2 was more common in elderly patients (p = 0.023) and vascular NG2 was associated with better tumor differentiation (p = 0.035). Notably, vascular NG2 was expressed in half of the patients with left colon cancer, although it was not expressed in a majority of those with right colon cancer (50.9 vs. 17.7%, p = 0.041). Conclusion: Both tumor cell and vascular NG2 expression were shown to be present in a significant number of patients with CRC and this makes NG2 a double target for anti-tumor therapies. Such therapies might be more effective for elderly patients with well-differentiated left colon cancer. © 2017 S. Karger AG, Basel.
- Published
- 2019
8. Serum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitis
- Author
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Cengiz, Cem and Cengiz, Cem
- Abstract
Background/Aims: The aim of the present study was to analyze the diagnostic accuracy of serum eosinophilic cationic protein (ECP) for eosinophilic esophagitis (EoE) and the correlation of ECP with clinical, histopathological, laboratory, and endoscopic features of EoE. Materials and Methods: Fifteen patients with EoE and 14 healthy controls were included in the study. Demographic parameters were recorded. EoE Endoscopic Reference Score (EREFS) was calculated according to endoscopic features, and esophageal biopsies were obtained by a single experienced endoscopist in a patient group. Serum ECP levels (mu g/mL), absolute eosinophil count (U/mm(3)), and maximum peak of eosinophils/high-power field in esophageal biopsies were analyzed. Results: The median age of all participants was 33.0 (min-max: 18-46) years. There were 27 (93.1%) male patients. Serum ECP level was significantly higher in patients with EoE than in healthy volunteers (20.4 vs. 8.8, p0.0001). According to the receiver operating characteristic (ROC) curve analysis, ECP had 80% sensitivity and 92.8% specificity to diagnose EoE with a cut-off value of 13.9 mu g/mL (area under the ROC curve 0.895; p0.0001; 95% CI: 0.725-0.978). EREFS (p0.0001) and the presence of food impaction (p=0.04) were significantly correlated with ECP. Conclusion: Serum ECP is an accurate non-invasive biomarker for EoE with high specificity and sensitivity. In addition, ECP is strongly correlated with EREFS and the symptom of food impaction.
- Published
- 2019
9. Gastrointestinal hemorrhage and its management in geriatric age group
- Author
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Oğuz, Dilek, Cengiz, Cem, Oğuz, Dilek, and Cengiz, Cem
- Abstract
Approximately 35%-40% of geriatric patients seek medical care for gastrointestinal symptoms at least once a year. At least 1% of the population aged over 80 years is hospitalized each year due to gastrointestinal hemorrhage. Gastrointestinal hemorrhage is frequently observed in this population and associated with high mortality and morbidity. Also, gastrointestinal hemorrhage is one of the main causes of hospitalization among geriatric patients. Geriatric patients with GIH constitute a subgroup of patients requiring special care in hospitals. The bleeding may occur in the upper or lower gastrointestinal tract and manifest itself with a variety of symptoms depending on its location. The incidence and natural course of hemorrhage are affected by antiplatelet and anticoagulant medications. The outcome of gastrointestinal hemorrhage in geriatric patients depends largely on the characteristics of bleeding lesion and comorbidities.
- Published
- 2019
10. Gastrointestinal hemorrhage and its management in geriatric population
- Author
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CENGİZ, Cem, primary and OĞUZ, Dilek, additional
- Published
- 2019
- Full Text
- View/download PDF
11. A rare cause of iron deficiency anemia and dyspepsia: A gigantic Brunner’s gland hamartoma of the duodenum.
- Author
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CENGİZ, Cem, primary
- Published
- 2017
- Full Text
- View/download PDF
12. Nerve/Glial Antigen 2: A Novel Target for Anti-Tumor Therapy in Colorectal Cancer
- Author
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Cengiz, Cem, primary, Bulut, Safak, additional, Boyacioglu, A. Sedat, additional, and Kuzu, M. Ayhan, additional
- Published
- 2017
- Full Text
- View/download PDF
13. Özgün Görüntüler İlginç bir ERCP komplikasyonu (Dormia basket kırılması)
- Author
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KURAN, Sedef Ö., CENGİZ, Cem, ÇELEBİ, Selman, PARLAK, Erkan, and ŞAHİN, Burhan
- Published
- 2015
14. Kolonik tip idiopatik kronik intestinal psödoobstrüksiyon: Kolonun Parkinson hastalığı mı?
- Author
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CENGİZ, Cem, PAMPAL, Kutluk, and BOYACIOĞLU, Sedat
- Subjects
Idiopathic chronic intestinal pseudoobstruction,Parkinson's disease ,İdiopatik kronik intestinal psödoobstrüksiyon,Parkinson hastalığı - Abstract
A 75-year-old woman with a history of Parkinson's disease and chronic constipation developed progressive abdominal distention and pain following consecutive operations for hip fracture. She became bedridden and her nutritional status deteriorated with poor oral intake. She was admitted with abdominal distention, pain, malnutrition, and dehydration. Given her past history and clinical, radiological and endoscopic findings, she was diagnosed with colonic-type chronic intestinal pseudoobstruction. Despite fluid and electrolyte replacement, nutritional support and prokinetic medicines, her condition did not improve. Serial enemas and attempts at colonic decompression failed to relieve severe distention and pain sufficiently. Although prophylactic antibiotic treatment was given, she died of sepsis likely due to bacterial translocation and microperforations. Parkinson's disease may be a predisposing condition to colonictype chronic intestinal pseudoobstruction., Parkinson hastalığı ve kronik konstipasyon öyküsü olan 75 yaşında bayan hastada kalça kırığı için geçirdiği iki operasyon sonrası giderek artan karında şişkinlik ve ağrı başlamış. Bu süreçte yatağa bağımlı hale gelen hastanın oral alım bozukluğu nedeniyle beslenme durumu kötüleşmiş. Hasta abdominal distansiyon, karın ağrısı, malnütrisyon ve dehidratasyon ile servise yatırıldı. Öyküsü, klinik, radyolojik ve endoskopik bulguları eşliğinde kolonik tip kronik intestinal psödoobstrüksiyon tanısı aldı. Sıvı-elektrolit replasmanı, beslenme desteği ve prokinetik ajanlara rağmen durumunda iyileşme olmadı. İleri derecede distansiyon ve karın ağrısını gidermeye yönelik seri enema ve kolonik dekompresyon çabaları sonuçsuz kaldı. Profilaktik antibiyotik tedavisine rağmen muhtemel bakteriyel translokasyon ve mikroperforasyonlara bağlı olarak gelişen sepsis nedeniyle exitus oldu. Parkinson hastalığı kolonik tip kronik intestinal psödoobstrüksiyon için yatkınlık oluşturan bir durum olabilir.
- Published
- 2015
15. Direk perkütan endoskopik jejunostomi (DPEJ): Olgu serisi ve derleme
- Author
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CENGİZ, Cem
- Subjects
Direk perkütan endoskopik jejunostomi,nütrisyon,teknik ,Direct percutaneous endoscopic jejunostomy,nutrition,technique - Abstract
Since its initial use in 1981, percutaneous endoscopic gastrostomy has been the method of choice for many patients requiring nutrition through enteral access. However, in the presence of gastroparesis or distortion of the normal stomach and duodenum anatomy, the risk of aspiration in 30% of patients warrants jejunal feeding. Jejunal feeding was first achievable in 1984 by means of a catheter inserted through the percutaneous endoscopic gastrostomy and advanced to the jejunum (PEG-J). However, the efficacy of this method is unsatisfactory due to the small diameter and clogging or kinking of the catheter used for jejunal feeding as well as to failure to always position it at the desired distance and its retrograde migration into the stomach. As a result, reintervention is often required and aspiration risk is not significantly decreased at all. Direct percutaneous jejunostomy was first described by Shike et al. in 1987 in patients who underwent gastrojejunostomy and/or gastrectomy. In 1991, Shike used this technique in patients with normal stomach and duodenum anatomy. Ponsky modified the technique thereafter and used the "pull technique" of percutaneous endoscopic gastrostomy for direct percutaneous jejunostomy. We herein report six cases with comprehensive information about direct percutaneous jejunostomy performed in our unit., Perkütan endoskopik gastrostomi, 1981 yılında ilk uygulamasını takiben, enteral yaklaşımla beslenmeye ihtiyaç duyan birçok hastada tercih edilen işlem olmuştur. Bununla beraber, gastroparezi veya mide-duodenum anatomisinin bozulması nedeniyle %30 kadar hastada aspirasyon riski belirmiş ve jejunal beslenmeye gereksinim doğmuştur. Jejunal beslenme, ilk defa 1984 yılında kullanılmaya başlanan, perkütan endoskopik gastrostomiden geçirilerek jejunuma ilerletilen bir kateter yardımı ile yapılabilse de bu yöntemin etkinliği, jejunal beslenme için kullanılan kateter çapının dar olması, tıkanması veya kink yapması, kateterin her zaman istenen mesafeye yerleştirilememesi ve mideye geri düşmesi nedeniyle yetersizdir. Sayılan nedenlerden dolayı sıklıkla tekrar girişim gerektirmekte ve ayrıca hastalarda aspirasyon yine de olmaktadır. Direk perkütan endoskopik jejunostomi, ilk olarak 1987'de Shike ve ark. tarafından gastrojejunostomi ve/veya gastrektomi olan hastalarda tanımlanmıştır. 1991 yılında Shike, bu kez anatomik olarak normal mide ve duodenumu olan hastalarda bu tekniği kullanmıştır. Ponsky ise tekniği modifiye ederek perkütan endoskopik gastrostomi için uygulanan pull tekniğini direk perkütan endoskopik jejunostomi için kullanmıştır. Bu yazıda kliniğimizde 6 olgu nedeniyle gerçekleştirilen direk perkütan endoskopik jejunostomi hakkında kapsamlı bilgi sunulmaktadır.
- Published
- 2015
16. Özgün Görüntüler Distal ülseratif kolit hastasında periapendiküler enflamasyon
- Author
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CENGİZ, Cem, DİŞİBEYAZ, Selçuk, and ÜLKER, Aysel
- Published
- 2015
17. Gastrointestinal stromal tümörü taklit eden sıradışı bir gastrik ektopik pankreas olgusu
- Author
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CENGİZ, Cem, OĞUZ, Dilek, KARABULUT, Yasemin Yuyucu, SAVAŞ, Berna, and ALAÇAYIR, İskender
- Subjects
Ektopik pankreas,gastrointestinal stromal tümör,submukozal lezyon ,Ectopic pancreas,gastrointestinal stromal tumor,submucosal lesion - Abstract
Ectopic pancreas is a congenital heterotopic pancreatic tissue typically found in the gastric antrum incidentally. It is easily recognized by its small cratershaped appearance near pylorus on endoscopy. However, it may appear as large submucosal lesion in rare cases. It may not be possible to differentiate ectopic pancreas from stromal tumor and leiyomyoma in all cases even by tomography or endoscopic ultrasound. We report an unusual case of ectopic pancreas which appeared as submucosal lesion on endoscopy and diagnosed by surgical resection., Ektopik pankreas genellikle mide antrumunda tesadüfen tespit edilen konjenital heterotopik pankreas dokusudur. Endoskopide, pilora yakın küçük krater şeklinde görüntüsüyle kolayca tanınır. Ancak nadir durumlarda büyük submukozal lezyon olarak ta izlenebilir. Tomografi ve endoskopik ultrasonografiyle bile stromal tümörler ve leiyomiyomdan ayırt edilmesi her zaman mümkün olmayabilir. Bu yazıda, üst endoskopide antrumda submukozal lezyon olarak değerlendirilip cerrahi rezeksiyon sonucu tanı alan sıradışı bir ektopik pankreas olgusu sunulmaktadır.
- Published
- 2015
18. Serum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitis
- Author
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Cem Cengiz, TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, TOBB ETU, Faculty of Medicine, Department of Internal Medical Sciences, and Cengiz, Cem
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,diagnosis ,Food impaction ,Biopsy ,education ,Esophageal Diseases ,Gastroenterology ,Severity of Illness Index ,eosinophilic cationic protein ,03 medical and health sciences ,Leukocyte Count ,Young Adult ,0302 clinical medicine ,fluids and secretions ,Esophagus ,Internal medicine ,Severity of illness ,medicine ,Humans ,Eosinophilic esophagitis ,Eosinophil cationic protein ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,Eosinophil Cationic Protein ,Eosinophilic Esophagitis ,Eosinophil ,Middle Aged ,medicine.disease ,Eosinophils ,medicine.anatomical_structure ,ROC Curve ,Food ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,030211 gastroenterology & hepatology ,Original Article ,Female ,Esophagoscopy ,business ,Biomarkers - Abstract
Background/Aims: The aim of the present study was to analyze the diagnostic accuracy of serum eosinophilic cationic protein (ECP) for eosinophilic esophagitis (EoE) and the correlation of ECP with clinical, histopathological, laboratory, and endoscopic features of EoE. Materials and Methods: Fifteen patients with EoE and 14 healthy controls were included in the study. Demographic parameters were recorded. EoE Endoscopic Reference Score (EREFS) was calculated according to endoscopic features, and esophageal biopsies were obtained by a single experienced endoscopist in a patient group. Serum ECP levels (mu g/mL), absolute eosinophil count (U/mm(3)), and maximum peak of eosinophils/high-power field in esophageal biopsies were analyzed. Results: The median age of all participants was 33.0 (min-max: 18-46) years. There were 27 (93.1%) male patients. Serum ECP level was significantly higher in patients with EoE than in healthy volunteers (20.4 vs. 8.8, p
- Published
- 2019
19. Serum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitis.
- Author
-
Cengiz C
- Subjects
- Adolescent, Adult, Biomarkers blood, Biopsy, Eosinophilic Esophagitis complications, Esophageal Diseases etiology, Esophagus pathology, Esophagus surgery, Female, Food adverse effects, Humans, Leukocyte Count, Male, Middle Aged, ROC Curve, Severity of Illness Index, Young Adult, Eosinophil Cationic Protein analysis, Eosinophilic Esophagitis blood, Eosinophils, Esophageal Diseases diagnosis, Esophagoscopy methods
- Abstract
Background/aims: The aim of the present study was to analyze the diagnostic accuracy of serum eosinophilic cationic protein (ECP) for eosinophilic esophagitis (EoE) and the correlation of ECP with clinical, histopathological, laboratory, and endoscopic features of EoE., Materials and Methods: Fifteen patients with EoE and 14 healthy controls were included in the study. Demographic parameters were recorded. EoE Endoscopic Reference Score (EREFS) was calculated according to endoscopic features, and esophageal biopsies were obtained by a single experienced endoscopist in a patient group. Serum ECP levels (μg/mL), absolute eosinophil count (U/mm3), and maximum peak of eosinophils/high-power field in esophageal biopsies were analyzed., Results: The median age of all participants was 33.0 (min-max: 18-46) years. There were 27 (93.1%) male patients. Serum ECP level was significantly higher in patients with EoE than in healthy volunteers (20.4 vs. 8.8, p<0.0001). According to the receiver operating characteristic (ROC) curve analysis, ECP had 80% sensitivity and 92.8% specificity to diagnose EoE with a cut-off value of 13.9 µg/mL (area under the ROC curve 0.895; p<0.0001; 95% CI: 0.725-0.978). EREFS (p<0.0001) and the presence of food impaction (p=0.04) were significantly correlated with ECP., Conclusion: Serum ECP is an accurate non-invasive biomarker for EoE with high specificity and sensitivity. In addition, ECP is strongly correlated with EREFS and the symptom of food impaction.
- Published
- 2019
- Full Text
- View/download PDF
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