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2. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections.

Author

Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri, Abbas, Ashraf, Ansaloni, Luca, Adesunkanmi, Abdulrashid, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Biffl, Walter, Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, deAngelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn, Di Bella, Stefano, Di Saverio, Salomone, Duane, Therese, Fugazzola, Paola, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos, Griffiths, Ewen, Hardcastle, Timothy, Hecker, Andreas, Herzog, Torsten, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter, Kim, Jae, Kirkpatrick, Andrew, Kong, Victor, Koshy, Renol, Inaba, Kenji, Isik, Arda, Ivatury, Rao, Labricciosa, Francesco, Lee, Yeong, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Maier, Ronald, Marinis, Athanasios, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest, Moore, Frederick, Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos, Ouadii, Mouaqit, Peitzman, Andrew, Perrone, Gennaro, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert, Shelat, Vishal, Sugrue, Michael, Tarasconi, Antonio, Tolonen, Matti, Viaggi, Bruno, Celotti, Andrea, Casella, Claudio, Pagani, Leonardo, Dhingra, Sameer, Baiocchi, Gian, Catena, Fausto, and Galante, Joseph

Subjects
Necrotizing infections, Necrotizing soft-tissue infections, Skin and soft-tissue infections, Critical Pathways, Humans, Soft Tissue Infections, United States
Abstract

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections.Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs.An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.

Published
2022

3. Towards the Healthcare of the Future. A Delphi Consensus on Environmental Sustainability Issues

Author

Dal Mas, Francesca, Previtali, Pietro, Denicolai, Stefano, Alvaro, Matteo, Biancuzzi, Helena, Campostrini, Stefano, Cutti, Sara, Grancini, Giulia, Magnani, Giovanna, Re, Beatrice, Reali, Alessandro, Venturi, Alessandro, Ambrosio, Alberto Giovanni, Boscagli, Giacomo, Bruni, Gianlorenzo, Calogero, Giuseppe, Camerini, Gaia, Cannarozzo, Antonio, Cantoni, Rita, Casazzo, Teodoro, Casella, Claudio, Ceresetti, Gabriele, Di Bartolo, Giuseppe, Domimagni, Cristina, Grechi, Maria Francesca, Liggeri, Silvia, Marzi, Ilaria, Mauri, Milena, Moioli, Gianpietro, Morabito, Maria Concetta, Palazzo, Giovanni, Panizzoli, Giuseppina, Passarella, Sabrina, Paternoster, Marco, Raimondi, Lucio, Rottoli, Elisa Maria, Salzillo, Adelina, Schiavini, Paolo, Tallarita, Enrico Antonio, Vassena, Sara, Cobianchi, Lorenzo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor

Published
2023
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6. Genotoxic and neurotoxic potential of intracellular nanoplastics: A review.

Author

Casella, Claudio and Ballaz, Santiago J.

Subjects
PLASTIC scrap, BIOLOGICAL membranes, ENDOPLASMIC reticulum, CELL cycle, ENVIRONMENTAL toxicology
Abstract

Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) of 1–100‐nm size, thereby littering the environment and posing a threat to wildlife and human health. Research on NPL contamination has up to now focused on the ecotoxicology effects of the pollution rather than the health risks. This review aimed to speculate about the possible properties of carcinogenic and neurotoxic NPL as pollutants. Given their low‐dimensional size and high surface size ratio, NPLs can easily penetrate biological membranes to cause functional and structural damage in cells. Once inside the cell, NPLs can interrupt the autophagy flux of cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, and induce endoplasmic reticulum stress. Harmful metabolic and biological processes induced by NPLs include oxidative stress (OS), ROS generation, and pro‐inflammatory reactions. Depending on the cell cycle status, NPLs may direct DNA damage, tumorigenesis, and lately carcinogenesis in tissues with high self‐renewal capabilities like epithelia. In cells able to live the longest like neurons, NPLs could trigger neurodegeneration by promoting toxic proteinaceous aggregates, OS, and chronic inflammation. NPL genotoxicity and neurotoxicity are discussed based on the gathered evidence, when available, within the context of the intracellular uptake of these newcomer nanoparticles. In summary, this review explains how the risk evaluation of NPL pollution for human health may benefit from accurately monitoring NPL toxicokinetics and toxicodynamics at the intracellular resolution level. Plastic waste disintegrates into nanoplastic particles (NPLs), whose health hazards are unknown. This review deals with their carcinogenic and neurotoxic potential. Given their low‐dimensional size and high surface size ratio, NPLs can easily penetrate cells to provoke structural and functional damages through OS and pro‐inflammatory reactions, which may cause carcinogenesis and/or neurodegeneration. The NPL role in these diseases is discussed within the context of the intracellular uptake of these newcomer nanoparticles. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Advancements in Materials Science and Photocatalysts for Sustainable Development.

Author

Vadivel, Dhanalakshmi, Suryakumar, Swetha, Casella, Claudio, Speltini, Andrea, and Dondi, Daniele

Subjects
MATERIALS science, SUSTAINABLE chemistry, SUSTAINABILITY, CHEMICAL reactions, RENEWABLE natural resources, SUSTAINABLE design, SUSTAINABLE development
Abstract

Materials science and catalysis advancements play a critical role in achieving sustainable development by managing environmental, energy, and resource challenges. Catalyst design advancements focus on enhancing selectivity to achieve sustainable chemical reactions, reducing energy consumption. Designing catalysts that are environmentally friendly and biodegradable is increasingly gaining importance. This aligns with the principles of green chemistry and contributes to minimizing the environmental impact of catalytic processes. These advances, taken as a whole, lead to more sustainable and efficient processes in industries ranging from energy production to pollutant removal, fueling the advancement toward a more sustainable future. Photochemistry, that is, the activation of a stable compound (catalyst) into the highly reactive excited state, is of particular importance, since photons—especially when they come from solar light—are a green and renewable resource. This review article has provided the overall idea of the photocatalysts and materials under green chemistry perspective from the standpoint of the concept of sustainable development. [ABSTRACT FROM AUTHOR]

Published
2024
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12. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri M., Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Biffl, Walter L., Boermeester, Marja A., Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Colak, Elif, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’ Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W., Dhingra, Sameer, Di Bella, Stefano, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Duane, Therese M., Enani, Mushira Abdulaziz, Fugazzola, Paola, Galante, Joseph M., Gachabayov, Mahir, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A., Hardcastle, Timothy C., Hecker, Andreas, Herzog, Torsten, Kabir, Syed Mohammad Umar, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K., Kim, Jae Il, Kirkpatrick, Andrew W., Kong, Victor, Koshy, Renol M., Kryvoruchko, Igor A., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao, Labricciosa, Francesco M., Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Machain, Gustavo M., Maier, Ronald V., Marinis, Athanasios, Marmorale, Cristina, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A., Ouadii, Mouaqit, Peitzman, Andrew B., Perrone, Gennaro, Pikoulis, Manos, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G., Segovia Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Stephens, Ian, Sugrue, Michael, Tarasconi, Antonio, Tochie, Joel Noutakdie, Tolonen, Matti, Tomadze, Gia, Ulrych, Jan, Vereczkei, Andras, Viaggi, Bruno, Gurioli, Chiara, Casella, Claudio, Pagani, Leonardo, Baiocchi, Gian Luca, and Catena, Fausto

Published
2021
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14. Perforated and bleeding peptic ulcer: WSES guidelines

Author

Tarasconi, Antonio, Coccolini, Federico, Biffl, Walter L., Tomasoni, Matteo, Ansaloni, Luca, Picetti, Edoardo, Molfino, Sarah, Shelat, Vishal, Cimbanassi, Stefania, Weber, Dieter G., Abu-Zidan, Fikri M., Campanile, Fabio C., Di Saverio, Salomone, Baiocchi, Gian Luca, Casella, Claudio, Kelly, Michael D., Kirkpatrick, Andrew W., Leppaniemi, Ari, Moore, Ernest E., Peitzman, Andrew, Fraga, Gustavo Pereira, Ceresoli, Marco, Maier, Ronald V., Wani, Imtaz, Pattonieri, Vittoria, Perrone, Gennaro, Velmahos, George, Sugrue, Michael, Sartelli, Massimo, Kluger, Yoram, and Catena, Fausto

Published
2020
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18. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Author

Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Augustin, Goran Bala, Miklosh Baraket, Oussama Biffl, Walter L. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Corsi, Daniela Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris de'Angelis, Nicola and Delibegovic, Samir Demetrashvili, Zaza De Simone, Belinda and de Jonge, Stijn W. Di Bella, Stefano Di Saverio, Salomone and Duane, Therese M. Fugazzola, Paola Galante, Joseph M. and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Karamarkovic, Aleksandar Khokha, Vladimir and Kim, Peter K. Kim, Jae Il Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. Inaba, Kenji Isik, Arda Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh Leppaniemi, Ari and Litvin, Andrey Luppi, Davide Maier, Ronald V. Marinis, Athanasios Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pintar, Tadeja Pipitone, Giuseppe Podda, Mauro and Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio Sawyer, Robert G. and Shelat, Vishal G. Sugrue, Michael Tarasconi, Antonio and Tolonen, Matti Viaggi, Bruno Celotti, Andrea Casella, Claudio Pagani, Leonardo Dhingra, Sameer Baiocchi, Gian Luca and Catena, Fausto

Abstract

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.

Published
2022

20. Varied Recurrent Laryngeal Nerve Course Is Associated with Increased Risk of Nerve Dysfunction During Thyroidectomy: Results of the Surgical Anatomy of the Recurrent Laryngeal Nerve in Thyroid Surgery Study, an International Multicenter Prospective Anatomic and Electrophysiologic Study of 1000 Monitored Nerves at Risk from the International Neural Monitoring Study Group

Author

Liddy, Whitney, primary, Wu, Che-Wei, additional, Dionigi, Gianlorenzo, additional, Donatini, Gianluca, additional, Giles Senyurek, Yasemin, additional, Kamani, Dipti, additional, Iwata, Ayaka, additional, Wang, Bo, additional, Okose, Okenwa, additional, Cheung, Anthony, additional, Saito, Yoshiyuki, additional, Casella, Claudio, additional, Aygun, Nurcihan, additional, Uludag, Mehmet, additional, Brauckhoff, Katrin, additional, Carnaille, Bruno, additional, Tunca, Fatih, additional, Barczyński, Marcin, additional, Kim, Hoon Yub, additional, Favero, Emerson, additional, Innaro, Nadia, additional, Vamvakidis, Kyriakos, additional, Serpell, Jonathan, additional, Romanchishen, Anatoly F., additional, Takami, Hiroshi, additional, Chiang, Feng-Yu, additional, Schneider, Rick, additional, Dralle, Henning, additional, Shin, Jennifer J., additional, Abdelhamid Ahmed, Amr H., additional, and Randolph, Gregory W., additional

Published
2021
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21. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Atanasov, Boyko and Augustin, Goran Bala, Miklosh Baraket, Oussama Baral, Suman and Biffl, Walter L. Boermeester, Marja A. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Colak, Elif Corsi, Daniela and Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris and Angelis, Nicola De' Delibegovic, Samir Demetrashvili, Zaza and De Simone, Belinda de Jonge, Stijn W. Dhingra, Sameer Di Bella, Stefano Di Marzo, Francesco Di Saverio, Salomone and Dogjani, Agron Duane, Therese M. Enani, Mushira Abdulaziz and Fugazzola, Paola Galante, Joseph M. Gachabayov, Mahir and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Kabir, Syed Mohammad Umar Karamarkovic, Aleksandar Khokha, Vladimir Kim, Peter K. Il Kim, Jae and Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. and Kryvoruchko, Igor A. Inaba, Kenji Isik, Arda Iskandar, Katia and Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh and Leppaniemi, Ari Litvin, Andrey Luppi, Davide Machain, Gustavo M. Maier, V, Ronald Marinis, Athanasios Marmorale, Cristina Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pikoulis, Manos Pintar, Tadeja Pipitone, Giuseppe and Podda, Mauro Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio and Sawyer, Robert G. Lohse, Helmut Segovia Sganga, Gabriele and Shelat, Vishal G. Stephens, Ian Sugrue, Michael Tarasconi, Antonio Tochie, Joel Noutakdie Tolonen, Matti Tomadze, Gia and Ulrych, Jan Vereczkei, Andras Viaggi, Bruno Gurioli, Chiara Casella, Claudio Pagani, Leonardo Baiocchi, Gian Luca and Catena, Fausto

Subjects
embryonic structures
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.

Published
2021

22. Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status

Author

Lai, Silvia, Mazzaferro, Sandro, Mitterhofer, Anna Paola, Tinti, Francesca, Bonci, Enea, Giovannetti, Antonello, Casella, Claudio, Perrotta, Adolfo Marco, Bagordo, Domenico, Murciano, Manuel, Galani, Alessandro, Celani, Camilla, Troiani, Patrizia, Cimino, Giuseppe, and Palange, Paolo

Subjects
Article Subject
Abstract

Background. Cystic fibrosis (CF) is one of the most frequent genetic diseases. The discovery and implementation of new therapies prolonged the survival of CF patients in the last years. Evaluation of long-term complications could be useful to improve the outcome of these patients. Aim of the Study. To evaluate renal function, metabolic, nutritional, and inflammatory status in CF patients on cystic fibrosis transmembrane regulator (CFTR) modulators therapy as well as lung transplant recipients (LRs) and patients on conservative therapy (control group). Materials and Methods. We performed a prospective, longitudinal study on 69 CF patients. Clinical and laboratory parameters (metabolic and nutritional indices and inflammatory markers) were evaluated in all patients before starting CFTR therapy or transplant (T0) and after 3 years (T1). Results. We enrolled 69 CF patients (42 males). Patients were distributed into three groups. The average age was 35.01 ± 10.57 years for the control group (group 0), 32.47 ± 9.40 years for patients on CFTR modulators therapy (group 1), and 38.93 ± 7.14 years for LRs (group 2). At T1, we showed a significant difference among the three groups in terms of renal function indices: creatinine, eGFR, serum nitrogen as well as serum uric acid, sodium, and potassium (p

Published
2020
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24. Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology?

Author

Cappelli, Carlo, primary, Pirola, Ilenia, additional, Gandossi, Elena, additional, Rotondi, Mario, additional, Lombardi, Davide, additional, Casella, Claudio, additional, Marini, Fiorella, additional, Saullo, Maura, additional, Agosti, Barbara, additional, Di Lodovico, Elena, additional, Chiovato, Luca, additional, Ferlin, Alberto, additional, and Castellano, Maurizio, additional

Published
2020
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26. p.Ser891Ala RET gene mutations in medullary thyroid cancer: Phenotypical and genealogical characterization of 28 apparently unrelated kindreds and founder effect uncovering in Northern Italy

Author

Giacché, Mara, primary, Panarotto, Alessandra, additional, Tacchetti, Maria Chiara, additional, Tosini, Rossella, additional, Campana, Federica, additional, Mori, Luigi, additional, Cappelli, Carlo, additional, Pirola, Ilenia, additional, Lombardi, Davide, additional, Pezzola, Diego Cesare, additional, Casella, Claudio, additional, and Castellano, Maurizio, additional

Published
2019
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28. Thyroid scintigraphy in the era of fine‐needle aspiration cytology.

Author

Pirola, Ilenia, Di Lodovico, Elena, Casella, Claudio, Pezzaioli, Letizia, Facondo, Paolo, Ferlin, Alberto, Lombardi, Davide, and Cappelli, Carlo

Subjects
IODINE deficiency, NEEDLE biopsy, RADIONUCLIDE imaging, THYROID nodules, THYROID gland, CYTOLOGY, GOLD standard
Abstract

Purpose: To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine‐needle aspiration cytology (FNA). Methods: We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test administered in our hospital at least two months before the FNA; where the TSH level was ≤1.5 mIU/L, the patients were subjected to a scan and subsequently to FNA, where indicated. We selected only healthy patients with no previous history of thyroid disease, who were not taking any drugs and who had a TSH level of ≤1.5 mIU/L. We excluded patients with multinodular goitre. Results: A total of 176 patients were analysed. A total of 67/176 patients (38%) showed a serum of TSH ≤ 0.27 mIU/L. Scintigraphy identified a hot nodule in 142 lesions (80.7%), a warm nodule in 8 lesions (4.5%) and a cold nodule in 26 lesions (14.8%). The ROC curve analysis indicated that a TSH value of ≤0.42 mIU/L identified patients with hyperfunctioning nodules with a sensitivity of 65% and a specificity of 77%. All patients with cold and warm nodules were submitted to FNA: 22/26 (85%) and 5/8 (63%) lesions showed suspected malignancy or were compatible with malignancy, respectively. Conclusion: Speculating on our data, if we had subjected our patients to FNA as indicated by the 2015 ATA guidelines, we would have subjected 117 patients to cytology, from whom 83 had undetected hot nodules. Conversely, by adopting scintigraphy for all patients with TSH ≤ 1.5 mIU/L, 109 patients have avoided FNA. However, our study was performed in a region with a history of mild iodine deficiency. Therefore, we cannot claim that our observation is valid for patients born and living in areas with sufficient iodine uptake. We recommend thyroid scintigraphy for treating single thyroid nodules in euthyroid patients born and living in regions with an iodine deficiency, when TSH levels are below 1.5 mIU/L before FNA. [ABSTRACT FROM AUTHOR]

Published
2021
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29. L'actigrafia

Author

Casella, Claudio, Marsicano, Sergio, Negrini, Lorella, and Pirovano, Marco

Published
2017

36. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Author

Massimo Sartelli, Federico Coccolini, Yoram Kluger, Ervis Agastra, Fikri M. Abu-Zidan, Ashraf El Sayed Abbas, Luca Ansaloni, Abdulrashid Kayode Adesunkanmi, Goran Augustin, Miklosh Bala, Oussama Baraket, Walter L. Biffl, Marco Ceresoli, Elisabetta Cerutti, Osvaldo Chiara, Enrico Cicuttin, Massimo Chiarugi, Raul Coimbra, Daniela Corsi, Francesco Cortese, Yunfeng Cui, Dimitris Damaskos, Nicola de’Angelis, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Stijn W. de Jonge, Stefano Di Bella, Salomone Di Saverio, Therese M. Duane, Paola Fugazzola, Joseph M. Galante, Wagih Ghnnam, George Gkiokas, Carlos Augusto Gomes, Ewen A. Griffiths, Timothy C. Hardcastle, Andreas Hecker, Torsten Herzog, Aleksandar Karamarkovic, Vladimir Khokha, Peter K. Kim, Jae Il Kim, Andrew W. Kirkpatrick, Victor Kong, Renol M. Koshy, Kenji Inaba, Arda Isik, Rao Ivatury, Francesco M. Labricciosa, Yeong Yeh Lee, Ari Leppäniemi, Andrey Litvin, Davide Luppi, Ronald V. Maier, Athanasios Marinis, Sanjay Marwah, Cristian Mesina, Ernest E. Moore, Frederick A. Moore, Ionut Negoi, Iyiade Olaoye, Carlos A. Ordoñez, Mouaqit Ouadii, Andrew B. Peitzman, Gennaro Perrone, Tadeja Pintar, Giuseppe Pipitone, Mauro Podda, Kemal Raşa, Julival Ribeiro, Gabriel Rodrigues, Ines Rubio-Perez, Ibrahima Sall, Norio Sato, Robert G. Sawyer, Vishal G. Shelat, Michael Sugrue, Antonio Tarasconi, Matti Tolonen, Bruno Viaggi, Andrea Celotti, Claudio Casella, Leonardo Pagani, Sameer Dhingra, Gian Luca Baiocchi, Fausto Catena, Sartelli, M, Coccolini, F, Kluger, Y, Agastra, E, Abu-Zidan, F, Abbas, A, Ansaloni, L, Adesunkanmi, A, Augustin, G, Bala, M, Baraket, O, Biffl, W, Ceresoli, M, Cerutti, E, Chiara, O, Cicuttin, E, Chiarugi, M, Coimbra, R, Corsi, D, Cortese, F, Cui, Y, Damaskos, D, De'Angelis, N, Delibegovic, S, Demetrashvili, Z, De Simone, B, de Jonge, S, Di Bella, S, Di Saverio, S, Duane, T, Fugazzola, P, Galante, J, Ghnnam, W, Gkiokas, G, Gomes, C, Griffiths, E, Hardcastle, T, Hecker, A, Herzog, T, Karamarkovic, A, Khokha, V, Kim, P, Kim, J, Kirkpatrick, A, Kong, V, Koshy, R, Inaba, K, Isik, A, Ivatury, R, Labricciosa, F, Lee, Y, Leppaniemi, A, Litvin, A, Luppi, D, Maier, R, Marinis, A, Marwah, S, Mesina, C, Moore, E, Moore, F, Negoi, I, Olaoye, I, Ordonez, C, Ouadii, M, Peitzman, A, Perrone, G, Pintar, T, Pipitone, G, Podda, M, Rasa, K, Ribeiro, J, Rodrigues, G, Rubio-Perez, I, Sall, I, Sato, N, Sawyer, R, Shelat, V, Sugrue, M, Tarasconi, A, Tolonen, M, Viaggi, B, Celotti, A, Casella, C, Pagani, L, Dhingra, S, Baiocchi, G, Catena, F, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervi, Abu-Zidan, Fikri M, Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Biffl, Walter L, Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitri, De'Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W, Di Bella, Stefano, Di Saverio, Salomone, Duane, Therese M, Fugazzola, Paola, Galante, Joseph M, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A, Hardcastle, Timothy C, Hecker, Andrea, Herzog, Torsten, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K, Kim, Jae Il, Kirkpatrick, Andrew W, Kong, Victor, Koshy, Renol M, Inaba, Kenji, Isik, Arda, Ivatury, Rao, Labricciosa, Francesco M, Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Maier, Ronald V, Marinis, Athanasio, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E, Moore, Frederick A, Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A, Ouadii, Mouaqit, Peitzman, Andrew B, Perrone, Gennaro, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ine, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G, Shelat, Vishal G, Sugrue, Michael, Tarasconi, Antonio, Tolonen, Matti, Viaggi, Bruno, Celotti, Andrea, Casella, Claudio, Pagani, Leonardo, Dhingra, Sameer, Baiocchi, Gian Luca, Catena, Fausto, HUS Abdominal Center, II kirurgian klinikka, and University of Helsinki

Subjects
MESH, FOURNIERS GANGRENE, RD1-811, Soft Tissue Infections / surgery, Necrotizing infections, Necrotizing soft-tissue infections, Skin and soft-tissue infections, Critical Pathways, Humans, United States, Soft Tissue Infections, Review, DIAGNOSIS, NECROTIZING FASCIITIS, Skin and soft-tissue infection, MANAGEMENT, INTRAVENOUS IMMUNOGLOBULIN, RISK, HERNIA REPAIR, RC86-88.9, RESISTANT STAPHYLOCOCCUS-AUREUS, Medical emergencies. Critical care. Intensive care. First aid, Necrotizing infection, 3126 Surgery, anesthesiology, intensive care, radiology, ENDOSONOGRAPHY, Necrotizing soft-tissue infection, Emergency Medicine, Surgery
Abstract

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections.Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs.An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.

Published
2022

37. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Cristian Mesina, Oussama Baraket, Arda Isik, Iyiade Olaoye, Tadeja Pintar, Wagih Ghnnam, Andreas Hecker, Ionut Negoi, Andrey Litvin, A R K Adesunkanmi, Julival Ribeiro, Stijn W. de Jonge, Norio Sato, Carlos Augusto Gomes, Manos Pikoulis, Federico Coccolini, Yeong Yeh Lee, Frederick A. Moore, Gustavo M. Machain, Francesco Cortese, Elif Colak, Luca Ansaloni, Daniela Corsi, Enrico Cicuttin, Fikri M. Abu-Zidan, Fausto Catena, Andrew W. Kirkpatrick, Raul Coimbra, I. A. Kryvoruchko, Chiara Gurioli, Paola Fugazzola, Gabriele Sganga, András Vereczkei, Sanjay Marwah, Kenji Inaba, Agron Dogjani, Antonio Tarasconi, Elisabetta Cerutti, Rao R. Ivatury, Ibrahima Sall, Michael Sugrue, Francesco M. Labricciosa, Marco Ceresoli, Renol M. Koshy, Jae Il Kim, Goran Augustin, Mauro Podda, Therese M. Duane, Katia Iskandar, Osvaldo Chiara, Dimitris Damaskos, Timothy Craig Hardcastle, Yunfeng Cui, Vishal G Shelat, Joel Noutakdie Tochie, Andrew B. Peitzman, Sameer Dhingra, Miklosh Bala, Ashraf Abbas, Samir Delibegovic, Leonardo Pagani, George Gkiokas, Claudio Casella, Mahir Gachabayov, Gabriel Rodrigues, Stefano Di Bella, Vladimir Khokha, Kemal Rasa, Nicola de’ Angelis, Ernest E. Moore, Robert G. Sawyer, Ronald V. Maier, Yoram Kluger, Ines Rubio-Perez, Victor Y. Kong, Gennaro Perrone, Francesco Di Marzo, Jan Ulrych, Gian Luca Baiocchi, Matti Tolonen, Athanasios Marinis, Cristina Marmorale, G. Tomadze, Peter K. Kim, Belinda De Simone, Aleksandar Karamarkovic, Ian Stephens, Mouaqit Ouadii, Massimo Sartelli, Davide Luppi, Boyko Atanasov, Helmut Alfredo Segovia Lohse, Ervis Agastra, Syed Mohammad Umar Kabir, Massimo Chiarugi, Carlos A. Ordoñez, Giuseppe Pipitone, Bruno Viaggi, Joseph M. Galante, Suman Baral, Ewen A. Griffiths, Mushira Enani, Marja A. Boermeester, Zaza Demetrashvili, Ari Leppäniemi, Torsten Herzog, Walter L. Biffl, Salomone Di Saverio, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervi, Abu-Zidan, Fikri M, Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Biffl, Walter L, Boermeester, Marja A, Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Colak, Elif, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitri, De' Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W, Dhingra, Sameer, Di Bella, Stefano, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Duane, Therese M, Enani, Mushira Abdulaziz, Fugazzola, Paola, Galante, Joseph M, Gachabayov, Mahir, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A, Hardcastle, Timothy C, Hecker, Andrea, Herzog, Torsten, Kabir, Syed Mohammad Umar, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K, Kim, Jae Il, Kirkpatrick, Andrew W, Kong, Victor, Koshy, Renol M, Kryvoruchko, Igor A, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao, Labricciosa, Francesco M, Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Machain, Gustavo M, Maier, Ronald V, Marinis, Athanasio, Marmorale, Cristina, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E, Moore, Frederick A, Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A, Ouadii, Mouaqit, Peitzman, Andrew B, Perrone, Gennaro, Pikoulis, Mano, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ine, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G, Segovia Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G, Stephens, Ian, Sugrue, Michael, Tarasconi, Antonio, Tochie, Joel Noutakdie, Tolonen, Matti, Tomadze, Gia, Ulrych, Jan, Vereczkei, Andra, Viaggi, Bruno, Gurioli, Chiara, Casella, Claudio, Pagani, Leonardo, Baiocchi, Gian Luca, Catena, Fausto, Sartelli, M, Coccolini, F, Kluger, Y, Agastra, E, Abu-Zidan, F, Abbas, A, Ansaloni, L, Adesunkanmi, A, Atanasov, B, Augustin, G, Bala, M, Baraket, O, Baral, S, Biffl, W, Boermeester, M, Ceresoli, M, Cerutti, E, Chiara, O, Cicuttin, E, Chiarugi, M, Coimbra, R, Colak, E, Corsi, D, Cortese, F, Cui, Y, Damaskos, D, de' Angelis, N, Delibegovic, S, Demetrashvili, Z, De Simone, B, de Jonge, S, Dhingra, S, Di Bella, S, Di Marzo, F, Di Saverio, S, Dogjani, A, Duane, T, Enani, M, Fugazzola, P, Galante, J, Gachabayov, M, Ghnnam, W, Gkiokas, G, Gomes, C, Griffiths, E, Hardcastle, T, Hecker, A, Herzog, T, Kabir, S, Karamarkovic, A, Khokha, V, Kim, P, Kim, J, Kirkpatrick, A, Kong, V, Koshy, R, Kryvoruchko, I, Inaba, K, Isik, A, Iskandar, K, Ivatury, R, Labricciosa, F, Lee, Y, Leppaniemi, A, Litvin, A, Luppi, D, Machain, G, Maier, R, Marinis, A, Marmorale, C, Marwah, S, Mesina, C, Moore, E, Moore, F, Negoi, I, Olaoye, I, Ordonez, C, Ouadii, M, Peitzman, A, Perrone, G, Pikoulis, M, Pintar, T, Pipitone, G, Podda, M, Rasa, K, Ribeiro, J, Rodrigues, G, Rubio-Perez, I, Sall, I, Sato, N, Sawyer, R, Segovia Lohse, H, Sganga, G, Shelat, V, Stephens, I, Sugrue, M, Tarasconi, A, Tochie, J, Tolonen, M, Tomadze, G, Ulrych, J, Vereczkei, A, Viaggi, B, Gurioli, C, Casella, C, Pagani, L, Baiocchi, G, Catena, F, HUS Abdominal Center, II kirurgian klinikka, and University of Helsinki

Subjects
Review, DAMAGE CONTROL LAPAROTOMY, Intra-abdominal infections, Peritonitis, Sepsis, Anti-Bacterial Agents, Critical Pathways, Humans, Treatment Outcome, Anti-Infective Agents, Intraabdominal Infections, 0302 clinical medicine, PERFORATED DIVERTICULITIS, Medicine, LAPAROSCOPIC CHOLECYSTECTOMY, Surgical approach, Iais, biology, Peritoniti, Anti-Infective Agents / therapeutic use, Medical emergencies. Critical care. Intensive care. First aid, 3. Good health, SURGICAL-TREATMENT, 030220 oncology & carcinogenesis, embryonic structures, Emergency Medicine, 030211 gastroenterology & hepatology, KLEBSIELLA-PNEUMONIAE, medicine.medical_specialty, RD1-811, Sepsi, MEDLINE, ANTIBIOTIC-THERAPY, 03 medical and health sciences, Intra-abdominal infection, Emergency surgery, Effective treatment, COMPUTED-TOMOGRAPHY, Intensive care medicine, Anti-Bacterial Agents / therapeutic use, Task force, business.industry, RC86-88.9, Abdominal Infection, SEPTIC SHOCK, Intraabdominal Infections / surgery, 3126 Surgery, anesthesiology, intensive care, radiology, biology.organism_classification, Review article, PRIMARY RESECTION, ACUTE COLONIC DIVERTICULITIS, Surgery, business, Intraabdominal Infections / drug therapy
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.

Published
2021

38. Thyroid scintigraphy in the era of fine-needle aspiration cytology.

Author

Pirola I, Di Lodovico E, Casella C, Pezzaioli L, Facondo P, Ferlin A, Lombardi D, and Cappelli C

Abstract

Purpose: To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA)., Methods: We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test administered in our hospital at least two months before the FNA; where the TSH level was ≤1.5 mIU/L, the patients were subjected to a scan and subsequently to FNA, where indicated. We selected only healthy patients with no previous history of thyroid disease, who were not taking any drugs and who had a TSH level of ≤1.5 mIU/L. We excluded patients with multinodular goitre., Results: A total of 176 patients were analysed. A total of 67/176 patients (38%) showed a serum of TSH ≤ 0.27 mIU/L. Scintigraphy identified a hot nodule in 142 lesions (80.7%), a warm nodule in 8 lesions (4.5%) and a cold nodule in 26 lesions (14.8%). The ROC curve analysis indicated that a TSH value of ≤0.42 mIU/L identified patients with hyperfunctioning nodules with a sensitivity of 65% and a specificity of 77%. All patients with cold and warm nodules were submitted to FNA: 22/26 (85%) and 5/8 (63%) lesions showed suspected malignancy or were compatible with malignancy, respectively., Conclusion: Speculating on our data, if we had subjected our patients to FNA as indicated by the 2015 ATA guidelines, we would have subjected 117 patients to cytology, from whom 83 had undetected hot nodules. Conversely, by adopting scintigraphy for all patients with TSH ≤ 1.5 mIU/L, 109 patients have avoided FNA. However, our study was performed in a region with a history of mild iodine deficiency. Therefore, we cannot claim that our observation is valid for patients born and living in areas with sufficient iodine uptake. We recommend thyroid scintigraphy for treating single thyroid nodules in euthyroid patients born and living in regions with an iodine deficiency, when TSH levels are below 1.5 mIU/L before FNA., (© 2020 John Wiley & Sons Ltd.)

Published
2020
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