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1. Lung Function and Symptoms of Exposure to the Volcanic Eruption in the Canary Islands: First Follow-Up of the ASHES Study

Author

Candal-Pedreira, Cristina, Díaz-Pérez, David, Velasco, Valle, Casanova, Ciro, Acosta, Orlando, Peces-Barba, Germán, Barreiro, Esther, Cañas, Ana, Castaño, Argelia, Cruz Carmona, María Jesús, Diego, Carmen, Garcia-Aymerich, Judith, Martínez, Cristina, Molina-Molina, María, Muñoz, Xavier, Sánchez-Íñigo, Francisco Javier, and Ruano-Ravina, Alberto

Published
2024
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2. Triple Therapy and Clinical Control in B+ COPD Patients: A Pragmatic, Prospective, Randomized Trial

Author

Agusti, Alvar, Lopez-Campos, José Luis, Miravitlles, Marc, Soler-Cataluña, Juan Jose, Marin, Jose Maria, Cosio, Borja G., Alcázar-Navarrete, Bernardino, Echave-Sustaeta, Jose Maria, Casanova, Ciro, Peces-Barba, German, de-Torres, Juan Pablo, Fernandez-Villar, Alberto, Ancochea, Julio, Villar-Alvarez, Felipe, Roman-Rodriguez, Miguel, Molina, Jesus, Garcia-Rivero, Juan Luis, Gonzalez, Cruz, Sobradillo, Patricia, Faner, Rosa, Peña, Carolina, Sharma, Raj, Izquierdo, José Luis, and Celli, Bartolome R.

Published
2024
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4. Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts: The BODE and CHAIN Experience

Author

de-Torres, Juan P., Casanova, Ciro, Marín, José M., Cabrera, Carlos, Marín, Marta, Ezponda, Ana, Cosio, Borja G., Martínez, Cristina, Solanes, Ingrid, Fuster, Antonia, Calle, Myriam, Peces-Barba, Germán, Gotera, Carolina, Feu-Collado, Nuria, Marin, Alicia, Alcaide, Ana Belén, Sangro, Matilde, Bastarrika, Gorka, and Celli, Bartolome R.

Published
2024
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5. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano-Ravina, Alberto

Published
2023
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16. Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population.

Author

Loeb, Eduardo, Zock, Jan-Paul, Miravitlles, Marc, Rodríguez, Esther, Kromhout, Hans, Vermeulen, Roel, Soler-Cataluña, Juan José, Soriano, Joan B., García-Río, Francisco, de Lucas, Pilar, Alfageme, Inmaculada, Casanova, Ciro, González-Moro, José Rodríguez, Ancochea, Julio, Cosío, Borja G., and Ferrer Sancho, Jaume

Abstract

Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Author

Cosio, Borja G., Calle Rubio, Myrian, Casanova, Ciro, Cosio, Borja G., Calle Rubio, Myrian, and Casanova, Ciro

Abstract

Background: Asthma-COPD overlap syndrome (ACOS) has been recently described by international guidelines. A stepwise approach to diagnosis using usual features of both diseases is recommended although its clinical application is difficult. Methods: To identify patients with ACOS, a cohort of well-characterized patients with COPD and up to 1 year of follow-up was analyzed. We evaluated the presence of specific characteristics associated with asthma in this COPD cohort, divided into major criteria (bronchodilator test > 400 mL and 15% and past medical history of asthma) and minor criteria (blood eosinophils > 5%, IgE > 100 IU/mL, or two separate bronchodilator tests > 200 mL and 12%). We defined ACOS by the presence of one major criterion or two minor criteria. Baseline characteristics, health status (COPD Assessment Test [CAT]), BMI, airflow obstruction, dyspnea, and exercise capacity (BODE) index, rate of exacerbations, and mortality up to 1 year of follow-up were compared between patients with and without criteria for ACOS. Results: Of 831 patients with COPD included,125 (15%) fulfilled the criteria for ACOS, and 98.4% of them sustained these criteria after 1 year. Patients with ACOS were predominantly male (81.6%), with symptomatic mild to moderate disease (67%), who were receiving inhaled corticosteroids (63.2%). There were no significant differences in baseline characteristics, and only survival was worse in patients with non-ACOS COPD after 1 year of follow-up (P < .05). Conclusions: The proposed ACOS criteria are present in 15% of a cohort of patients with COPD and these patients show better 1-year prognosis than clinically similar patients with COPD with no ACOS criteria., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

25. COPD Clinical Control: predictors and long-term follow-up of the CHAIN cohort

Author

Calle Rubio, Myrian, Rodríguez Hermosa, Juan Luis, Torres, Juan P. de, Marín, José María, Martínez-González, Cristina, Fuster, Antonia, Cosío, Borja G., Peces-Barba, Germán, Solanes, Ingrid, Jose Luis, Feu-Collado, Nuria, Lopez-Campos, José Luis, Casanova, Ciro, Calle Rubio, Myrian, Rodríguez Hermosa, Juan Luis, Torres, Juan P. de, Marín, José María, Martínez-González, Cristina, Fuster, Antonia, Cosío, Borja G., Peces-Barba, Germán, Solanes, Ingrid, Jose Luis, Feu-Collado, Nuria, Lopez-Campos, José Luis, and Casanova, Ciro

Abstract

134 patients (16.8%) were considered persistently controlled, 248 (31.1%) persistently uncontrolled and 416 (52.1%) changed control status during follow-up. The variables significantly associated with persistent control were not requiring triple therapy at baseline and having a better quality of life. Annual changes in outcomes (health status, psychological status, airflow limitation) did not differ in patients, regardless of clinical control status. All-cause mortality was lower in persistently controlled patients (5.5% versus 19.1%, p = 0.001). The hazard ratio for all-cause mortality was 2.274 (95% CI 1.394–3.708; p = 0.001). Regarding pharmacological treatment, triple inhaled therapy was the most common option in persistently uncontrolled patients (72.2%). Patients with persistent disease control more frequently used bronchodilators for monotherapy (53%) at recruitment, although by the end of the follow-up period, 20% had scaled up their treatment, with triple therapy being the most frequent therapeutic pattern., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

26. Differential Effect of Modified Medical Research Council Dyspnea, COPD Assessment Test, and Clinical COPD Questionnaire for Symptoms Evaluation Within the New GOLD Staging and Mortality in COPD

Author

Casanova, Ciro, Lucas Ramos, Pilar De, Calle Rubio, Myrian, de Torres, Juan P., Casanova, Ciro, Lucas Ramos, Pilar De, Calle Rubio, Myrian, and de Torres, Juan P.

Abstract

Objective: The modified Medical Research Council (mMRC) dyspnea, the COPD Assessment Test (CAT), and the Clinical COPD Questionnaire (CCQ) have been interchangeably proposed by GOLD (Global Initiative for Chronic Obstructive Lung Disease) for assessing symptoms in patients with COPD. However, there are no data on the prognostic value of these tools in terms of mortality. We endeavored to evaluate the prognostic value of the CAT and CCQ scores and compare them with mMRC dyspnea. Methods: We analyzed the ability of these tests to predict mortality in an observational cohort of 768 patients with COPD (82% men; FEV1, 60%) from the COPD History Assessment in Spain (CHAIN) study, a multicenter observational Spanish cohort, who were monitored annually for a mean follow-up time of 38 months. Results: Subjects who died (n = 73; 9.5%) had higher CAT (14 vs 11, P = .022), CCQ (1.6 vs 1.3, P = .033), and mMRC dyspnea scores (2 vs 1, P < .001) than survivors. Receiver operating characteristic analysis showed that higher CAT, CCQ, and mMRC dyspnea scores were associated with higher mortality (area under the curve: 0.589, 0.588, and 0.649, respectively). CAT scores ≥ 17 and CCQ scores > 2.5 provided a similar sensitivity than mMRC dyspnea scores ≥ 2 to predict all-cause mortality. Conclusions: The CAT and the CCQ have similar ability for predicting all-cause mortality in patients with COPD, but were inferior to mMRC dyspnea scores. We suggest new thresholds for CAT and CCQ scores based on mortality risk that could be useful for the new GOLD grading classification., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

27. Sex differences between women and men with COPD: A new analysis of the 3CIA study

Author

Perez, Tamara Alonso, Castillo, Elena García, Ancochea, Julio, Pastor Sanz, María Teresa, Almagro, Pere, Martínez-Camblor, Pablo, Miravitlles, Marc, Rodríguez-Carballeira, Mónica, Navarro, Annie, Lamprecht, Bernd, Ramírez-García Luna, Ana S., Kaiser, Bernhard, Alfageme, Inmaculada, Casanova, Ciro, Esteban, Cristóbal, Soler-Cataluña, Juan J., De-Torres, Juan P., Celli, Bartolomé R., Marin, Jose M., Lopez-Campos, Jose L., Riet, Gerben Ter, Sobradillo, Patricia, Lange, Peter, Garcia-Aymerich, Judith, Anto, Josep M., Turner, Alice M., Han, MeiLan K., Langhammer, Arnulf, Sternberg, Alice, Leivseth, Linda, Bakke, Per, Johannessen, Ane, Oga, Toru, Cosío, Borja, Echazarreta, Andres, Roche, Nicolas, Burgel, Pierre-Régis, Sin, Don D., Puhan, Milo A., and Soriano, Joan B.

Published
2020
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28. Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

Author

Córdoba-Lanús, Elizabeth, primary, Montuenga, Luis M., additional, Domínguez-de-Barros, Angélica, additional, Oliva, Alexis, additional, Mayato, Delia, additional, Remírez-Sanz, Ana, additional, Gonzalvo, Francisca, additional, Celli, Bartolomé, additional, Zulueta, Javier J., additional, and Casanova, Ciro, additional

Published
2024
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29. Home noninvasive ventilation in severe COPD: in whom does it work and how?

Author

Raveling, Tim, primary, Vonk, Judith M., additional, Hill, Nicholas S., additional, Gay, Peter C., additional, Casanova, Ciro, additional, Clini, Enrico, additional, Köhnlein, Thomas, additional, Márquez-Martin, Eduardo, additional, Schneeberger, Tessa, additional, Murphy, Patrick B., additional, Struik, Fransien M., additional, Kerstjens, Huib A.M., additional, Duiverman, Marieke L., additional, and Wijkstra, Peter J., additional

Published
2024
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44. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, Ruano Raviña, Alberto, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano Raviña, Alberto

Abstract

Introduction There is still uncertainty about which aspects of cigarette smoking influence the risk of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to estimate the COPD risk as related to duration of use, intensity of use, lifetime tobacco consumption, age of smoking initiation and years of abstinence. Methods We conducted an analytical cross-sectional study based on data from the EPISCAN-II study (n = 9092). All participants underwent a face-to-face interview and post-bronchodilator spirometry was performed. COPD was defined as post-bronchodilator FEV1/FVC < 70%. Parametric and nonparametric logistic regression models with generalized additive models were used. Results 8819 persons were included; 858 with COPD and 7961 without COPD. The COPD risk increased with smoking duration up to ≥50 years [OR 3.5 (95% CI: 2.3–5.4)], with smoking intensity up to ≥39 cig/day [OR 10.1 (95% CI: 5.3–18.4)] and with lifetime tobacco consumption up to >29 pack-years [OR 3.8 (95% CI: 3.1–4.8)]. The COPD risk for those who started smoking at 22 or later was 0.9 (95% CI: 0.6–1.4). The risk of COPD decreased with increasing years of cessation. In comparison with both never smokers and current smokers, the lowest risk of COPD was found after 15–25 years of abstinence. Conclusion COPD risk increases with duration, intensity, and lifetime tobacco consumption and decreases importantly with years of abstinence. Age at smoking initiation shows no effect. After 15–25 years of cessation, COPD risk could be equal to that of a never smoker. This work suggests that the time it takes to develop COPD in a smoker is about 30 years

Published
2023

45. Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

Author

Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica, Instituto de Salud Carlos III, Callejón-Leblic, Belén, Sánchez-Espirilla, Saida, Gotera-Rivera, Carolina, Santana, Rafael, Díaz-Olivares, Isabel, Marín, José María, Casanova, Ciro, García-Cosio, Borja, Fuster, Antonia, Solanes, Ingrid, Torres, Juan Pablo de, Feu-Collado, Nuria, Cabrera-López, Carlos, Amado, Carlos, Romero-Plaza, Amparo, Padrón Fraysse, Luis Alejandro, Márquez-Martín, Eduardo, Marín-Royo, Margarita, Balcells, Eva, Llunell Casanovas, Antonia, Martínez-González, Cristina, Galdíz Iturri, Juan Bautista, Lacárcel Bautista, Celia, Gómez-Ariza, José L., Pereira-Vega, Antonio, Seijo, Luis, López-Campos, J. L., Peces-Barba, Germán, García-Barrera, Tamara, Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica, Instituto de Salud Carlos III, Callejón-Leblic, Belén, Sánchez-Espirilla, Saida, Gotera-Rivera, Carolina, Santana, Rafael, Díaz-Olivares, Isabel, Marín, José María, Casanova, Ciro, García-Cosio, Borja, Fuster, Antonia, Solanes, Ingrid, Torres, Juan Pablo de, Feu-Collado, Nuria, Cabrera-López, Carlos, Amado, Carlos, Romero-Plaza, Amparo, Padrón Fraysse, Luis Alejandro, Márquez-Martín, Eduardo, Marín-Royo, Margarita, Balcells, Eva, Llunell Casanovas, Antonia, Martínez-González, Cristina, Galdíz Iturri, Juan Bautista, Lacárcel Bautista, Celia, Gómez-Ariza, José L., Pereira-Vega, Antonio, Seijo, Luis, López-Campos, J. L., Peces-Barba, Germán, and García-Barrera, Tamara

Abstract

Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.

Published
2023

46. Supplementary Material Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

Author

Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica, Instituto de Salud Carlos III, Callejón-Leblic, Belén, Sánchez-Espirilla, Saida, Gotera-Rivera, Carolina, Santana, Rafael, Díaz-Olivares, Isabel, Marín, José María, Casanova, Ciro, García-Cosio, Borja, Fuster, Antonia, Solanes, Ingrid, Torres, Juan Pablo de, Feu-Collado, Nuria, Cabrera-López, Carlos, Amado, Carlos, Romero-Plaza, Amparo, Padrón Fraysse, Luis Alejandro, Márquez-Martín, Eduardo, Marín-Royo, Margarita, Balcells, Eva, Llunell Casanovas, Antonia, Martínez-González, Cristina, Galdíz Iturri, Juan Bautista, Lacárcel Bautista, Celia, Gómez-Ariza, José L., Pereira-Vega, Antonio, Seijo, Luis, López-Campos, J. L., Peces-Barba, Germán, García-Barrera, Tamara, Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica, Instituto de Salud Carlos III, Callejón-Leblic, Belén, Sánchez-Espirilla, Saida, Gotera-Rivera, Carolina, Santana, Rafael, Díaz-Olivares, Isabel, Marín, José María, Casanova, Ciro, García-Cosio, Borja, Fuster, Antonia, Solanes, Ingrid, Torres, Juan Pablo de, Feu-Collado, Nuria, Cabrera-López, Carlos, Amado, Carlos, Romero-Plaza, Amparo, Padrón Fraysse, Luis Alejandro, Márquez-Martín, Eduardo, Marín-Royo, Margarita, Balcells, Eva, Llunell Casanovas, Antonia, Martínez-González, Cristina, Galdíz Iturri, Juan Bautista, Lacárcel Bautista, Celia, Gómez-Ariza, José L., Pereira-Vega, Antonio, Seijo, Luis, López-Campos, J. L., Peces-Barba, Germán, and García-Barrera, Tamara

Abstract

Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.

Published
2023

48. Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years

Author

Miravitlles, Marc, Soler-Cataluña, Juan José, Soriano, Joan B., García-Rio, Francisco, de Lucas, Pilar, Alfageme, Inmaculada, Casanova, Ciro, Rodríguez González-Moro, José Miguel, Sánchez Herrero, María Guadalupe, Ancochea, Julio, Cosio, Borja G, Universitat Autònoma de Barcelona, [Miravitlles, Marc] Hosp Univ Vall Hebron, Dept Pneumol, Vall dHebron Inst Recerca, Barcelona, Spain, [Miravitlles, Marc] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Soriano, Joan B.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Garcia-Rio, Francisco] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Ancochea, Julio] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Cosio, Borja G.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Hosp Arnau Vilanova Lliria, Serv Neumol, Valencia, Spain, [Soriano, Joan B.] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Ancochea, Julio] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Soriano, Joan B.] Univ Autonoma Madrid, Madrid, Spain, [Ancochea, Julio] Univ Autonoma Madrid, Madrid, Spain, [Garcia-Rio, Francisco] Hosp Univ Paz IdiPAZ, Serv Neumol, Madrid, Spain, [De Lucas, Pilar] Hosp Gen Gregorio Maranon, Serv Neumol, Madrid, Spain, [Alfageme, Inmaculada] Univ Seville, Hosp Univ Virgen Valme, Unidad Gest Clin Neumol, Seville, Spain, [Casanova, Ciro] Hosp Univ Nuestra Senora Candelaria, Serv Neumol, Tenerife, Spain, [Rodriguez Gonzalez-Moro, Jose Miguel] Univ Alcala, Hosp Univ Principe Asturias Alcala De Henares, Serv Neumol, Madrid, Spain, [Sanchez, Guadalupe] GSK, Dept Med, Madrid, Spain, [Cosio, Borja G.] Hosp Univ Son Espases IdISBa, Serv Neumol, Palma de Mallorca, Spain, Institut Català de la Salut, [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. [Soler-Cataluña JJ] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Valencia, Spain. [Soriano JB] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Princesa, and Universidad Autónoma de Madrid, Madrid, Spain. [García-Río F] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. [de Lucas P] Servicio de Neumología, Hospital General Gregorio Marañon, Madrid, Spain. [Alfageme I] Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Seville, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Pulmonary and Respiratory Medicine, Questionnaire, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Community, Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Physical-activity survey, Scale, Dyspnea, Respiratory Tract Diseases::Lung Diseases [DISEASES], Validation, Adults, Pulmons - Malalties - Epidemiologia, enfermedades respiratorias::enfermedades pulmonares [ENFERMEDADES], Copd, Mortality
Abstract

BackgroundFew large epidemiological studies have analysed the prevalence of respiratory symptoms and their determinants in the general adult population. We investigated the prevalence and determinants of respiratory symptoms and compared their prevalence with that of two previous studies conducted in 1999 and 2009.MethodEPISCAN II was a multicentre, cross-sectional, population-based epidemiological study in individuals older than 40 years.ResultsA total of 9092 individuals were included. Up to 47.5% reported at least one respiratory symptom, being more frequent in women than in men (49.4%versus45.5%, p=0.0002) and with wheezing being the most frequent (33.7%) followed by dyspnoea (26.8%). The presence of any symptom was associated with female sex, higher body mass index (BMI), lower forced expiratory volume in 1 s (FEV1% pred), reduced physical activity, a higher Charlson index and the presence of anxiety and depression. Smoking was also significantly associated with having at least one respiratory symptom in a dose–response fashion (OR: 1.415, 1.916, 2.192 and 2.987 for 0–10, 10–20, 20–30 and >30 pack-years, respectively, all pConclusionsApproximately half of the adult Spanish population have respiratory symptoms and this prevalence has remained quite stable over the last 20 years. Smoking remains the main factor associated with respiratory symptoms, but female sex, comorbidities, high BMI and low FEV1and low physical activity are also significantly associated with respiratory symptoms.

Published
2022

50. Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study

Author

Amado, Carlos A., primary, Martín-Audera, Paula, additional, Agüero, Juan, additional, Lavín, Bernardo A., additional, Guerra, Armando R., additional, Boucle, Daymara, additional, Ferrer-Pargada, Diego, additional, Berja, Ana, additional, Martín, Fernando, additional, Casanova, Ciro, additional, and García-Unzueta, Mayte, additional

Published
2023
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