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5. Contributors

Author

Alonso-Rasgado, Teresa, primary, Amini-Nik, Saeid, additional, Ashrafi, Mohammed, additional, Baguneid, Mohamed, additional, Baskin, Jeremy, additional, Bayat, Ardeshir, additional, Bélanger, Audrey, additional, Bernard, François-Xavier, additional, Berning, Manuel, additional, Boniface, Katia, additional, Bouez, Charbel, additional, Boukamp, Petra, additional, Boulais, Nicholas, additional, Bourland, Jennifer, additional, Buhé, Virginie, additional, Cario-André, Muriel, additional, Carré, Jean-Luc, additional, Cerqueira, Mariana T., additional, Chacón-Solano, Esteban, additional, Chau, David Y.S., additional, Chen, Vivien, additional, Chen, Lin, additional, Chéret, Jérémy, additional, Cotovio, José, additional, Davis, Stephen C., additional, Del Río, Marcela, additional, Dell'Anna, Maria L., additional, Deslauriers, Marianne, additional, DiPietro, Luisa A., additional, Drakulich, Stefan, additional, Duque-Fernandez, Alexandra, additional, Fradette, Julie, additional, Garlick, Jonathan A., additional, Gerami-Naini, Behzad, additional, Glinos, George D., additional, Gouin, Olivier, additional, Guerrero-Aspizua, Sara, additional, Hague, Adam, additional, Hewitt, Kyle, additional, Hutter, Victoria, additional, Jeschke, Marc G., additional, Kashpur, Olga, additional, Kirton, Stewart B., additional, Korosec, Ana, additional, Kulms, Dagmar, additional, Lago, Manuela E.L., additional, Larcher, Fernando, additional, Le Gall-Ianotto, Christelle, additional, Le Garrec, Raphaële, additional, Lebonvallet, Nicolas, additional, Leschiera, Raphaël, additional, L'Hérondelle, Killian, additional, Liang, Liang, additional, Lichtenberger, Beate M., additional, Lorthois, Isabelle, additional, Maheux, Maxim, additional, Marques, Alexandra P., additional, Martínez-Santamaría, Lucía, additional, Masson, Louis-Charles, additional, Mathes, Stephanie H., additional, Meier, Friedegund, additional, Misery, Laurent, additional, Morin, Alexandre, additional, Mukhamedshina, Nailia, additional, Nguyen, Deborah G., additional, Parker, Christian N., additional, Pastar, Irena, additional, Pavez Loriè, Elizabeth, additional, Pellevoisin, Christian, additional, Pereira, Ulysse, additional, Pirraco, Rogério P., additional, Pouliot, Roxane, additional, Reis, Rui L., additional, Retting, Kelsey N., additional, Rioux, Geneviève, additional, Roy, Bryan, additional, Sakka, Mehdi, additional, Sawaya, Andrew P., additional, Schrementi, Megan, additional, Seneschal, Julien, additional, Shamis, Yulia, additional, Simard, Mélissa, additional, Simard, Philippe, additional, Smith, Avi, additional, Stark, Hans-Jürgen, additional, Stojadinovic, Olivera, additional, Taieb, Alain, additional, Talagas, Matthieu, additional, Tomic-Canic, Marjana, additional, Wikramanayake, Tongyu Cao, additional, and Yousuf, Yusef, additional

Published
2018
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6. In vitro models to study cutaneous innervation mechanisms

Author

Lebonvallet, Nicolas, primary, Le Gall-Ianotto, Christelle, additional, Chéret, Jérémy, additional, Leschiera, Raphaël, additional, Talagas, Matthieu, additional, Le Garrec, Raphaële, additional, Buhé, Virginie, additional, L'Hérondelle, Killian, additional, Gouin, Olivier, additional, Sakka, Mehdi, additional, Boulais, Nicholas, additional, Pereira, Ulysse, additional, Carré, Jean-Luc, additional, and Misery, Laurent, additional

Published
2018
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11. How did the private labs fit onto COVID-19 crisis?

Author

Galhaud, Jean-Philippe, Scherrer, Florian, Kemeny, Stephan, Beauvieux, Marie-Christine, Delevallee, Céline, Aimone-Gastin, Isabelle, Alcaraz, Stéphanie, Allouche, Stephane, Balduyck, Malika, Barbe, Françoise, Barguil, Yann, Bastard, Jean Philippe, Beaudeux, Jean-Louis, Ben Lassoued, Amin, Benz-de Bretagne, Isabelle, Bérard, Annie, Bermont, Laurent, Bigot-Corbel, Edith, Bost, Muriel, Bourbonneux, Valery, Brunel, Valéry, Carré, Jean-Luc, Chenevier-Gobeaux, Camille, Chevrier, Marc, Chinetti, Giulia, Collin-Chavagnac, Delphine, Delacour, Hervé, Delevallée, Delphine, Desroys du Roure, François, Faure, Patrice, Galinier, Anne, Hauet, Thierry, Helj, Carine, Jolly, Emilie, Kamel, Saïd, Lehmann, Sylvain, Leroy, Aline, Lessenger, Jean-Marc, Levy, Pacifique, Lorec-Penet, Anne-Marie, Mesli, Samir, Monnet, Dagui, Moreau, Caroline, Mouly-Badina, Laurence, Nivet-Antoine, Valerie, Oueidat, Nathalie, Pecquet, Mathieu, Peoc'h, Katell, Pieroni, Laurence, Poupon, Carole, Roubille, Martine, Rucheton, Benoit, Sakka, Medhi, Sapin, Vincent, Saunier, Vincent, Schmitt, François, Zaepfel, Sabine, Zozor, Samuel, Groupe Labexa, Synlab Vallée du Rhône, Gen-Bio, CHU Bordeaux [Bordeaux], Centre de résonance magnétique des systèmes biologiques (CRMSB), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
030213 general clinical medicine, Medical laboratory, Pre-Analytical Phase, MESH: Medical Staff, 0302 clinical medicine, Medical Staff, MESH: COVID-19, Intersectoral Collaboration, MESH: Intersectoral Collaboration, Cross Infection, Equipment Safety, MESH: Clinical Laboratory Services, General Medicine, Clinical Laboratory Services, MESH: Pre-Analytical Phase, 3. Good health, MESH: Patient Safety, Private Sector, Medical emergency, France, Patient Safety, MESH: Private Sector, MESH: Hospital Units, Hospital Units, health crisis, 2019-20 coronavirus outbreak, MESH: Pandemics, private medical laboratories, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS CoV-2, Specimen Handling, 03 medical and health sciences, medicine, Humans, MESH: SARS-CoV-2, MESH: Specimen Handling, Pandemics, MESH: Clinical Laboratory Techniques, MESH: Humans, Health professionals, business.industry, Clinical Laboratory Techniques, SARS-CoV-2, pandemia, Cornerstone, COVID-19, MESH: Cross Infection, Front line, medicine.disease, MESH: Equipment Safety, MESH: France, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Confronted with the COVID-19 crisis, healthcare professionals have had to tackle an epidemic crisis of a huge magnitude for which they were not prepared. Medical laboratories have been on the front line, from collecting samples to performing the analysis required to diagnose this new pathology. Responding to the needs and to the urgency of the situation, the authorities relied on the network of private laboratories. In France, private laboratory medicine represents 70% of overall activity, and with a network of more than 4,000 local laboratories, private laboratory medicine has been the cornerstone of the « screen-trace-isolate » strategy. This article gives feedback from private laboratory medicine professionals, directly involved in the reorganization carried out at the pre-analytical, analytical and post-analytical stages, during the crisis from March to October 2020.

Published
2020

12. In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like

Author

Bataille, Adeline, Leschiera, Raphael, L’Hérondelle, Killian, Pennec, Jean-Pierre, Le Goux, Nelig, Mignen, Olivier, Sakka, Mehdi, Plée-Gautier, Emmanuelle, Brun, Cecilia, Oddos, Thierry, Carré, Jean-Luc, Misery, Laurent, Lebonvallet, Nicolas, Laboratoire sur les interactions Epithéliums Neurones (LIEN), and Université de Brest (UBO)

Subjects
Sensory Receptor Cells, [SDV]Life Sciences [q-bio], sensory neuron, Cell Differentiation, differentiation, adult stem cell, TRP, Article, lcsh:Biology (General), nervous system, Humans, lcsh:QH301-705.5, Cells, Cultured, Skin, Stem Cell Transplantation
Abstract

Skin-derived precursor cells (SKPs) are neural crest stem cells that persist in certain adult tissues, particularly in the skin. They can generate a large type of cell in vitro, including neurons. SKPs were induced to differentiate into sensory neurons (SNs) by molecules that were previously shown to be important for the generation of SNs: purmorphamine, CHIR99021, BMP4, GDNF, BDNF, and NGF. We showed that the differentiation of SKPs induced the upregulation of neurogenins. At the end of the differentiation protocol, transcriptional analysis was performed on BRN3A and a marker of pain-sensing nerve cell PRDM12 genes: 1000 times higher for PRDM12 and 2500 times higher for BRN3A in differentiated cells than they were in undifferentiated SKPs. Using immunostaining, we showed that 65% and 80% of cells expressed peripheral neuron markers BRN3A and PERIPHERIN, respectively. Furthermore, differentiated cells expressed TRPV1, PAR2, TRPA1, substance P, CGRP, HR1. Using calcium imaging, we observed that a proportion of cells responded to histamine, SLIGKV (a specific agonist of PAR2), polygodial (a specific agonist of TRPA1), and capsaicin (a specific agonist of TRPV1). In conclusion, SKPs are able to differentiate directly into functional SNs. These differentiated cells will be very useful for further in vitro studies.

Published
2020

13. Itch Matrixes

Author

Najafi, Peyman, primary, Misery, Laurent, additional, Carré, Jean-Luc, additional, Ben Salem, Douraied, additional, and Dufor, Olivier, additional

Published
2021
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19. 13 - In vitro models to study cutaneous innervation mechanisms

Author

Lebonvallet, Nicolas, Le Gall-Ianotto, Christelle, Chéret, Jérémy, Leschiera, Raphaël, Talagas, Matthieu, Le Garrec, Raphaële, Buhé, Virginie, L'Hérondelle, Killian, Gouin, Olivier, Sakka, Mehdi, Boulais, Nicholas, Pereira, Ulysse, Carré, Jean-Luc, and Misery, Laurent

Published
2018
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20. Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes

Author

Misery, Laurent, Brenaut, Emilie, Pierre, Ophélie, Le Garrec, Raphaele, Gouin, Olivier, Lebonvallet, Nicolas, Abasq‐Thomas, Claire, Talagas, Matthieu, Le Gall‐Ianotto, Christelle, Besner‐Morin, Catherine, Fluhr, Joachim, Leven, Cyril, Chéret, Jérémy, Ponce, Leslie, Bertolini, Marta, Paus, Ralf, L’Herondelle, Killian, Fouyet, Sophie, Leschiera, Raphael, Le Gall-Ianotto, Christelle, Philippe, Reginald, Buscaglia, Paul, Mignen, Olivier, Lewis, Richard, Michel, Laurence, Devergne, C., Kerspern, H., Poizeau, F., Eveillard, J.R., Carré, J.L., Weisshaar, E., Evers, A.W.M., Huet, F., Ständer, S., Reich, A., Berardesca, E., Serra‐Baldrich, E., Wallengren, J., Linder, D., Fluhr, J.W., Szepietowski, J.C., Maibach, H., Honari, Golara, Takamori, Kenji, Richters, Renée, Barnetche, T., Roudot, A.‐C., Ficheux, A.‐S., Le Calloch, Ronan, Couturier, Marie‐Anne, Chauveau, Aurélie, Lippert, Eric, Carré, Jean‐Luc, Ianotto, Jean‐Christophe, Bataille, Adeline, Genin, Emmanuelle, L'Herondelle, Killian, Legoux, Nelig, Buhé, Virginie, Sakka, Mehdi, Kerfant, Nathalie, Carré, Jean-Luc, Lefeuvre, Luc, Université de Brest (UBO), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), and Laboratoire sur les interactions Epithéliums Neurones (LIEN)

Subjects
0301 basic medicine, Keratinocytes, ORAI1 Protein, [SDV]Life Sciences [q-bio], Primary Cell Culture, TRPV Cation Channels, Inflammation, Dermatitis, Dermatology, Biochemistry, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine, Humans, Inositol 1,4,5-Trisphosphate Receptors, Receptor, PAR-2, Calcium Signaling, RNA, Small Interfering, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Calcium signaling, Phospholipase C, ORAI1, NF-κB, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cell Differentiation, Cell Biology, Inositol trisphosphate receptor, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Tumor necrosis factor alpha, medicine.symptom, Inflammation Mediators, Keratinocyte, Oligopeptides, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

PAR2 activation in basal keratinocytes stimulates inflammation via the Ca2+-dependent production of mediators such as IL-1β, TNF-α, and TSLP. In this study, we investigated PAR2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR2-activating peptide SLIGKV promoted Ca2+ store depletion in both undifferentiated human primary keratinocytes and DhPKs. SLIGKV-evoked Ca2+ store depletion did not trigger the store-operated Ca2+ entry (i.e., SOCE) through ORAI1 in DhPKs compared with undifferentiated human primary keratinocytes. The inhibition of phospholipase C and the concomitant inhibition of TRPV1 and inositol triphosphate receptor in DhPKs abrogated the SLIGKV-evoked Ca2+ store depletion; NF-κB activity; and the production of inflammatory mediators such as IL-1β, TNF-α, and TSLP. Taken together, these results indicate a key role for both InsP3R and TRPV1 in Ca2+ internal stores in the PAR2-evoked Ca2+ release and consequent skin inflammation in DhPKs. These findings may provide clues to understanding the pathological role of DhPKs in skin disorders in which PAR2 is known to be involved, such as atopic dermatitis, Netherton syndrome, and psoriasis.

Published
2017

21. Gestion personnalisée du sang (GPS) : expérience du CHRU de Brest

Author

Le Niger, Catherine, primary, Vadam, Christophe, additional, Grayo, Claire Marine, additional, Le Roy, Julie, additional, Huet, Olivier, additional, Bodenes, Laeticia, additional, Aubron, Cécile, additional, Huiban, Brigitte, additional, Nguyen, Vinh, additional, Oilleau, Jean Ferreol, additional, Couturier, Marie Anne, additional, Guillerm, Gaelle, additional, Le Guen, Patrick, additional, Galinat, Hubert, additional, Carré, Jean-Luc, additional, Coutté, Marie-Bénédicte, additional, and Ozier, Yves, additional

Published
2019
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23. Systematic overestimation of human serum albumin by capillary zone electrophoresis method due to monoclonal immunoglobulin interferences

Author

Padelli, Maël, primary, Labouret, Théo, additional, Labarre, Marion, additional, Le Reun, Eymeric, additional, Rouillé, Amélie, additional, Kerspern, Hélène, additional, Capaldo, Clément, additional, Chauvet, Juliette, additional, Plée-Gautier, Emmanuelle, additional, Carré, Jean-Luc, additional, and Leven, Cyril, additional

Published
2019
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25. Is capillary zone electrophoresis a suitable method for estimating serum albumin: A comparison of four methods

Author

Padelli, Maël, primary, Leven, Cyril, additional, Le Reun, Eymeric, additional, Labouret, Théo, additional, Galakhoff, Nicolas, additional, Labarre, Marion, additional, Rouillé, Amélie, additional, Kerspern, Hélène, additional, Lapègue, Marion, additional, Chauvet, Juliette, additional, Plée-Gautier, Emmanuelle, additional, and Carré, Jean-Luc, additional

Published
2018
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26. Capteur microonde à base de résonateur planaire pour une analyse glycémique in-situ

Author

Srour, Mahdi, Potelon, Benjamin, Quendo, Cédric, Carré, Jean-Luc, Person, Christian, Lab-STICC_UBO_MOM_DIM, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Service de Biochimie et Biologie Moléculaire, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lab-STICC_TB_MOM_DIM, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192) (Lab-STICC), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université européenne de Bretagne - European University of Brittany (UEB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Quendo, Cedric, Université européenne de Bretagne - European University of Brittany (UEB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université européenne de Bretagne - European University of Brittany (UEB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), and Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Capteurs, Micro-ondes, [SPI.TRON] Engineering Sciences [physics]/Electronics, [SPI.TRON]Engineering Sciences [physics]/Electronics
Abstract

National audience; Cet article présente les premiers résultats de la conception et du développement d’un capteur microonde basé sur un résonateur à stub quart d’onde. L’idée de ce travail est d’utiliser des tubes à essai standards tels que ceux utilisés au CHRU de Brest remplis d’une solution aqueuse de glucose pour en déterminer sa concentration. L’interaction entre le champ électromagnétique et la solution (eau/glucose) à mesurer peut être observée en mesurant les variations des paramètres S entre 2 et 8 GHz. La technique présentée ci-après peut être utilisée pour d’autres liquides et solutions aqueuses.

Published
2017

27. Functional and Structural Brain Connectivity in Psoriasis Patients and Healthy Controls : a Brain Imaging Study After Exposure To Mentally-induced Itch

Author

Carré, Jean-Luc and Peyman , Najafi

Abstract

While psoriasis has been extensively studied as a prevalent dermatological disease, its impact on central nervous system is relatively unknown. We have employed MRI techniques in order to study the effect of mentally-induced itch and to reveal if any differences exist between psoriasis patients and healthy subjects. Fourteen patients with chronic psoriasis and fifteen healthy controls were asked to watch two itch inducing videos consisting of people scratching themselves in the scanner. Considering functional connectivity, our results showed that an interconnected network of brain regions was more connected in patients than in healthy controls. This network involves many regions among which the cerebellum, the antero-posterior cingulate gyrus, the thalami and the para-hippocampal and hippocampal gyri play a central role. This network mostly gathers regions involved in either itching or chronic pain sensation but not only. We show that this network can be easily divided into two subnetworks for which the variations observed are not in the same proportions when compared to healthy subjects. Our analysis of DTI images showed that chronic itch can also affect the microstructure of white matter by increasing the fractional anisotropy measure in several tracts connecting the above mentioned areas for patients.With cautious interpretations and further replication of these results, we propose that the subnetwork encoding the perception and control of itch sensation is much more affected than the rest of the network representing mentalizing and empathy. With an approach consisting of measuring microstructural changes at a local level in the brain, we also contradict the findings obtained with global measures which stated that chronic psoriasis cannot alter the anatomy of the brain. This confirms that itchy pathophysiological conditions have similar effects on functional and structural connectivity as those observed in chronic pain.

Published
2017

29. The presence of monoclonal gammopathy in Ph-negative myeloproliferative neoplasms is associated with a detrimental effect on outcomes

Author

Le Clech, Lenaïg, primary, Sakka, Mehdi, additional, Meskar, Ahmed, additional, Kerspern, Helene, additional, Eveillard, Jean-Richard, additional, Berthou, Christian, additional, Buors, Caroline, additional, Lippert, Eric, additional, Guillerm, Gaelle, additional, Quintin-Roué, Isabelle, additional, Carré, Jean-Luc, additional, and Ianotto, Jean-Christophe, additional

Published
2017
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31. Rôle inflammatoire et voie de signalisation intracellulaire de PAR-2 dans les kératinocytes différenciés

Author

Gouin, Olivier, primary, Mignen, Olivier, additional, L’Herondelle, Killian, additional, Le Garrec, Raphaele, additional, Le Gall-Ianotto, Christelle, additional, Sakka, Mehdi, additional, Leschiera, Raphael, additional, Talagas, Matthieu, additional, Buhé, Virginie, additional, Plée-Gautier, Emanuelle, additional, Carré, Jean-Luc, additional, Lefeuvre, Luc, additional, Lebonvallet, Nicolas, additional, and Misery, Laurent, additional

Published
2016
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32. Signature Electromagnétique du Glucose dans le Sang Humain

Author

Potelon, Benjamin, Quendo, Cédric, Carré, Jean-Luc, Chevalier, Alexis, Person, Christian, Queffelec, Patrick, Chevalier, Alexis, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Lab-STICC_UBO_MOM_DIM, Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Service de Biochimie et Biologie Moléculaire, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lab-STICC_UBO_MOM_MF, Département Micro-Ondes (MO), and Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)

Subjects
[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, Electromagnetism, Blood, Characterization, [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism
Abstract

National audience; Cet article propose une caractérisation électromagnétique de solutions aqueuses contenant du glucose en concentrations variables. La nouveauté de notre travail réside dans des mesures large-bande, y compris à des fréquences relativement élevées. En outre, le comportement singulier sur une large bande de fréquence lié à la présence de glucose est ensuite observé de nouveau dans un milieu complexe : le sang humain.

Published
2015

37. Pathophysiological Study of Sensitive Skin.

Author

BUHÉ, Virginie, VIÉ, Katell, GUÉRÉ, Christelle, NATALIZIO, Audrey, LHÉRITIER, Céline, GALL-IANOTTO, Christelle LE, HUET, Flavien, TALAGAS, Matthieu, LEBONVALLET, Nicolas, MARCORELLES, Pascale, CARRÉ, Jean-Luc, and MISERY, Laurent

Subjects
SKIN diseases, PATHOLOGICAL physiology, ITCHING, INNERVATION, NEUROPATHY, ULTRAVIOLET radiation, DIAGNOSIS
Abstract

Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation of peripheral innervation, the pathophysiogeny of sensitive skin remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive or sensitive skin and demonstrated that the intraepidermal nerve fibre density, especially that of peptidergic C-fibres, was lower in the sensitive skin group. These fibres are involved in pain, itching and temperature perception, and their degeneration may promote allodynia and similar symptoms. These results suggest that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fibre neuropathy, and that environmental factors may alter skin innervation. [ABSTRACT FROM AUTHOR]

Published
2016
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40. Placebo and nocebo effects as major components of the treatment of itch.

Author

Misery, Laurent and Carré, Jean‐Luc

Subjects
*PLACEBOS, *NOCEBOS, *SKIN disease treatment, *SKIN diseases, *ITCHING, *PATIENTS, *THERAPEUTICS
Abstract

The article discusses how learned immune function can optimize dermatological treatments through the placebo effect and nocebo effects. Topics discussed include placebo and nocebo effects being the positive or negative treatment effects that depends exclusively of the patient's expectations about a treatment outcome, its consequences for itch treatment, and meta-analysis of clinical trials of oral systemic medication showing substantial effects on itch of placebo medications.

Published
2017
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41. Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 »

Author

Marie-Christine, Beauvieux, Annie M, Bérard, Isabelle, Aimone-Gastin, Françoise, Barbé, Yann, Barguil, Delphine, Collin-Chavagnac, Hervé, Delacour, Céline, Delevallée, Valérie, Nivet-Antoine, Katell, Peoc'h, Carole, Poupon, François, Schmitt, Laurence, Piéroni, Vincent, Sapin, Charlotte, Oris, CarMeN, laboratoire, CHU Bordeaux [Bordeaux], Centre de résonance magnétique des systèmes biologiques (CRMSB), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier territorial Gaston-Bourret [Nouméa], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Gen-Bio [Clermont-Ferrand] (Groupe Inovie ), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Beaujon, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier de Gonesse (CHU Gonesse), Groupe Hospitalier Bretagne Sud (GHBS), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Membres du Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 » Aimone-Gastin Isabelle, Alcaraz Stéphanie, Allouche Stéphane, Balduyck Malika, Barbé Franc¸oise, Barguil Yann, Bastard Jean-Philippe, Beaudeux Jean-Louis, Beauvieux Marie-Christine, Ben Lassoued Amin, Benz de Bretagne Isabelle, Bérard Annie, Bermont Laurent, Bigot-Corbel Edith, Bost Muriel, Bourbonneux Valery, Brunel Valery, Carré Jean-Luc, Chenevier-Gobeaux Camille, Chevrier Marc, Chinetti Giulia, Collin-Chavagnac Delphine, Delacour Hervé, Delevallée Delphine, Desroys du Roure Franc¸ois, Faure Patrice, Galhaud Jean-Philippe, Galinier Anne, Hauet Thierry, Hejl Carine, Jolly Emilie, Kamel Said, Lehmann Sylvain, Leroy Aline, Lessinger Jean-Marc, Levy Pacifique, LorecPenet Anne-Marie, Mesli Samir, Monnet Dagui, Moreau Caroline, Mouly Laurence, Nivet-Antoine Valérie, Oueidat Nathalie, Pecquet Mathieu, Peoc’h Katell, Piéroni Laurence, Poupon Carole, Roubille Martine, Rucheton Benoit, Sakka Medhi, Sapin Vincent, Saunier Vincent, Scherrer Florian, Schmitt Franc¸ois, Zaepfel Sabine, Zozor Samuel Liste des correspondants en biochimie Sous-groupe Privés Boulier Alexandre (Saint-Thibery), Saint Martin Chloé (Saint-Flour), Chatelain Rémi (Roanne), Deleglise Guillaume (Clermont-Ferrand), Froment Pauline (Ganges), Paulus Jean-Marcel (Nancy), Merah Kader (Saint-Denis), Sevin Eric (Limoges), Barrand Lionel (Strasbourg), Boetsch Morgane (Colmar), Lautier Carine (Montpellier), Charrier Frédéric (Arles), Magraff Stéphane (Brumath) Sous-groupe Outre-Mer (OM)/francophonie Cavalier Etienne (CHU Liège), Demar Magali (CH Cayenne), de Guire Vincent et Wang Han Ting (Montréal), Laso Bautista Javier (HFE Cerdagne), Dumas-Chastang Elsa (Papeete, ILM), Outreville Jonathan (Papeete, CHT Mamao), Tayeb Nicole (CH Mayotte), Monde Absalome (CHU Treichville Abidjan), Chiaradia Laura (CH Nouméa), Alomar Yves (CH de St Pierre & Miquelon), Devaud Francois (CH d’Uturoa), Diallo Agne Fatou, Kandji Pape Matar, Gueye Papa Madieye (CHU Fann, Sénégal), Temmar Abdelhakim (CHU de Guadeloupe), Sakandé Jean et Kabré Elie (CHU Yalgado Uuedraogo, Burkina Faso), Padelli Maël (CHU de Martinique), Chabraoui Layachi, pour la Fédération Internationale Francophone de Biologie et Médecine de Laboratoire (FIFBCML), Magny Eric (CHU Réunion) Sous-groupe CH Got Laurence et Francia Thomas (Orléans), Tournoys Marie-Hélène (Béthune), Morvan Cécile (Villefranche), Kadi Habiba (Gonesse), Balluet Rémi (Bourg-en-Bresse), Fissor-Magdelein Cristel (Monaco) Sous-groupe Hôpitaux d’instruction des armées (HIA) Vest Philippe (Clamart), Plantamura Julie (Toulon) Sous-groupe CHU Nord-Est Salignac Sylvain (Nancy), Maboudou Patrice et Onraed Brigitte (Lille), Schneider Nathalie et Szymezak Jean (Reims), Alemann Mathieu, Glady Ludovic, Lavaux Thomas, Kemmel Véronique, Lefevre Paul et Bayer Sophie (Strasbourg), Billoir Paul et Gueudin Marie (Rouen), Grandhomme Frédérique et Gondolf Clémentine (Caen) Sous-groupe CHU Ouest Moal Valérie et Larcher- Joubaud Franc¸oise (Angers), Guery Eve-Anne (Tours), Lefevre Charles, Collet Nicolas et Peltier Lucas (Rennes), Lacape Geneviève, Redonnet-Vernhet Isabelle, Richard Emmanuel et Gilleron Véronique (Bordeaux) Sous-groupe CHU Assistance publique-Hôpitaux de Paris (AP-HP) Czerkiewicz Isabelle (Henri Mondor), Vicca Stéphanie (Necker), Manceau Hanna (Beaujon), Boutten Anne (Bichat) Sous-groupe CHU Sud Ausseil Jérôme (Toulouse), Hamoir Maria, Zemori Laurence, Deconde-Lebutor Célia (Nice), Lamy Anaïs (Nîmes) Sous-groupe CHU Auvergne Rhône-Alpes-Bourgogne Franche-Comté (ARA-BFC) Gambert Ségolène (Dijon), Gonzalo Philippe (Saint-Etienne), Cartier Régine (Lyon), and Oris Charlotte (ClermontFerrand)

Subjects
030213 general clinical medicine, History, [SDV]Life Sciences [q-bio], Disease, France/epidemiology, Biochemistry, Community Networks, Disease Outbreaks, Viral/blood/*diagnosis/epidemiology, 0302 clinical medicine, Health care, Pandemic, Videoconferencing/organization & administration/standards, Intersectoral Collaboration, medical biology, Professional Practice, General Medicine, Clinical Laboratory Services, biological markers, 21st Century, 3. Good health, [SDV] Life Sciences [q-bio], France, Coronavirus Infections, Biomarkers/*analysis/blood, Societies, Scientific, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, Biochemistry/*organization & administration/standards, History, 21st Century, Scientific/*organization & administration/standards, 03 medical and health sciences, Betacoronavirus, Community Networks/organization & administration/standards/trends, medicine, Clinical Laboratory Services/*organization & administration/standards, Humans, Betacoronavirus/isolation & purification/pathogenicity, Medical prescription, China, Pandemics, Professional Practice/organization & administration/standards/trends, business.industry, SARS-CoV-2, COVID-19, Pneumonia, Private sector, Family medicine, covid-19, Coronavirus Infections/blood/*diagnosis/epidemiology, Videoconferencing, business, Societies, Biomarkers
Abstract

The SARS-CoV-2 virus is responsible for an epidemic disease called COVID-19, which was initially evidenced in Wuhan, China, and spread very rapidly in China and around the world. In France, the first isolated case seems now to be reported in December 2019, stage 3 of the COVID-19 epidemic was triggered on March 14(th), the start of the planned containment exit from May 11(th). Healthcare services have faced a large influx of patients who may be beyond their capacity to receive and care, particularly in the Large-East and Ile-de-France regions. Some patients show an evolution of the disease never observed before with other coronaviruses and develop in a few days a very important inflammatory reaction, which can lead to death of patients. A working group of the French Society of Clinical Biology (SFBC) was set up with the objective of providing updated information on the current status of the biological prescriptions (focusing on biochemistry ones) and their evolution during the epidemic, and of analyzing the biological parameters associated with comorbidities and patient evolution in order to link biological results with medical events. The expanded working group covers all sectors of medical biology in France and extends to the French-speaking world: hospital sectors (CHU and CH, Army Training Hospitals) and the private sector opening a field of view on the biological situation in establishments for dependent elderly, social establishments and clinical medical institutions. The purpose of this article is the presentation of this working group and its immediate and future actions., Le virus SARS-CoV-2 est responsable d’une maladie épidémique dénommée COVID-19 initialement mise en évidence à Wuhan (Chine) et qui s’est propagée très rapidement en Chine puis dans le monde entier. En France, le premier cas isolé semble être signalé dès la fin du mois de décembre2019, le stade 3 de l’épidémie a été déclenché le 14 mars 2020 et la sortie progressive du confinement est prévue à partir du 11 mai 2020. Les services de soins ont fait face à un afflux massif de patients pouvant déborder leurs capacités d’accueil et de prise en charge, notamment dans les régions Grand-Est et Ile-de-France. Certains patients présentent une évolution de la maladie encore jamais observée avec les coronavirus et développent en quelques jours une réaction inflammatoire très importante, pouvant mener au décès. Un groupe de travail de la Société française de biologie clinique (SFBC) s’est constitué, ayant pour objectif de faire le point sur les prescriptions biologiques et leur évolution au cours de l’épidémie, d’analyser les paramètres biologiques, avec un focus biochimique, associés aux comorbidités et à l’évolution du patient, dans le but de relier les résultats biologiques avec des évènements du parcours de soins du patient. Ce groupe de travail recouvre tous les secteurs publics (CHU, CH, Hôpitaux d’instruction des armées) et privés de la biologie médicale en France métropolitaine et ultra-marine ; il s’étend également à la francophonie. Il permet une vision large sur la situation biologique en milieu hospitalier, établissements d’hébergements de personnes âgées dépendantes (Ehpad), établissements médicaux sociaux (EMS) et en cliniques. Le but de cet article est la présentation de ce groupe de travail et ses actions immédiates et à venir.

Published
2020

42. Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 »

Author

Beauvieux, M. C., Bérard, A. M., Aimone-Gastin, I., Barbe, F., Barguil, Y., Collin-Chavagnac, D., Delacour, H., Delevallee, C., Nivet-Antoine, V., Peoc'H, K., Poupon, C., Schmitt, F., Piéroni, L., Sapin, V., CHU Bordeaux [Bordeaux], Centre de résonance magnétique des systèmes biologiques (CRMSB), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier territorial Gaston-Bourret [Nouméa], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Gen-Bio [Clermont-Ferrand] (Groupe Inovie ), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Beaujon, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier de Gonesse (CHU Gonesse), Groupe Hospitalier Bretagne Sud (GHBS), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Membres du Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 » Aimone-Gastin Isabelle, Alcaraz Stéphanie, Allouche Stéphane, Balduyck Malika, Barbé Franc¸oise, Barguil Yann, Bastard Jean-Philippe, Beaudeux Jean-Louis, Beauvieux Marie-Christine, Ben Lassoued Amin, Benz de Bretagne Isabelle, Bérard Annie, Bermont Laurent, Bigot-Corbel Edith, Bost Muriel, Bourbonneux Valery, Brunel Valery, Carré Jean-Luc, Chenevier-Gobeaux Camille, Chevrier Marc, Chinetti Giulia, Collin-Chavagnac Delphine, Delacour Hervé, Delevallée Delphine, Desroys du Roure Franc¸ois, Faure Patrice, Galhaud Jean-Philippe, Galinier Anne, Hauet Thierry, Hejl Carine, Jolly Emilie, Kamel Said, Lehmann Sylvain, Leroy Aline, Lessinger Jean-Marc, Levy Pacifique, LorecPenet Anne-Marie, Mesli Samir, Monnet Dagui, Moreau Caroline, Mouly Laurence, Nivet-Antoine Valérie, Oueidat Nathalie, Pecquet Mathieu, Peoc’h Katell, Piéroni Laurence, Poupon Carole, Roubille Martine, Rucheton Benoit, Sakka Medhi, Sapin Vincent, Saunier Vincent, Scherrer Florian, Schmitt Franc¸ois, Zaepfel Sabine, Zozor Samuel Liste des correspondants en biochimie Sous-groupe Privés Boulier Alexandre (Saint-Thibery), Saint Martin Chloé (Saint-Flour), Chatelain Rémi (Roanne), Deleglise Guillaume (Clermont-Ferrand), Froment Pauline (Ganges), Paulus Jean-Marcel (Nancy), Merah Kader (Saint-Denis), Sevin Eric (Limoges), Barrand Lionel (Strasbourg), Boetsch Morgane (Colmar), Lautier Carine (Montpellier), Charrier Frédéric (Arles), Magraff Stéphane (Brumath) Sous-groupe Outre-Mer (OM)/francophonie Cavalier Etienne (CHU Liège), Demar Magali (CH Cayenne), de Guire Vincent et Wang Han Ting (Montréal), Laso Bautista Javier (HFE Cerdagne), Dumas-Chastang Elsa (Papeete, ILM), Outreville Jonathan (Papeete, CHT Mamao), Tayeb Nicole (CH Mayotte), Monde Absalome (CHU Treichville Abidjan), Chiaradia Laura (CH Nouméa), Alomar Yves (CH de St Pierre & Miquelon), Devaud Francois (CH d’Uturoa), Diallo Agne Fatou, Kandji Pape Matar, Gueye Papa Madieye (CHU Fann, Sénégal), Temmar Abdelhakim (CHU de Guadeloupe), Sakandé Jean et Kabré Elie (CHU Yalgado Uuedraogo, Burkina Faso), Padelli Maël (CHU de Martinique), Chabraoui Layachi, pour la Fédération Internationale Francophone de Biologie et Médecine de Laboratoire (FIFBCML), Magny Eric (CHU Réunion) Sous-groupe CH Got Laurence et Francia Thomas (Orléans), Tournoys Marie-Hélène (Béthune), Morvan Cécile (Villefranche), Kadi Habiba (Gonesse), Balluet Rémi (Bourg-en-Bresse), Fissor-Magdelein Cristel (Monaco) Sous-groupe Hôpitaux d’instruction des armées (HIA) Vest Philippe (Clamart), Plantamura Julie (Toulon) Sous-groupe CHU Nord-Est Salignac Sylvain (Nancy), Maboudou Patrice et Onraed Brigitte (Lille), Schneider Nathalie et Szymezak Jean (Reims), Alemann Mathieu, Glady Ludovic, Lavaux Thomas, Kemmel Véronique, Lefevre Paul et Bayer Sophie (Strasbourg), Billoir Paul et Gueudin Marie (Rouen), Grandhomme Frédérique et Gondolf Clémentine (Caen) Sous-groupe CHU Ouest Moal Valérie et Larcher- Joubaud Franc¸oise (Angers), Guery Eve-Anne (Tours), Lefevre Charles, Collet Nicolas et Peltier Lucas (Rennes), Lacape Geneviève, Redonnet-Vernhet Isabelle, Richard Emmanuel et Gilleron Véronique (Bordeaux) Sous-groupe CHU Assistance publique-Hôpitaux de Paris (AP-HP) Czerkiewicz Isabelle (Henri Mondor), Vicca Stéphanie (Necker), Manceau Hanna (Beaujon), Boutten Anne (Bichat) Sous-groupe CHU Sud Ausseil Jérôme (Toulouse), Hamoir Maria, Zemori Laurence, Deconde-Lebutor Célia (Nice), Lamy Anaïs (Nîmes) Sous-groupe CHU Auvergne Rhône-Alpes-Bourgogne Franche-Comté (ARA-BFC) Gambert Ségolène (Dijon), Gonzalo Philippe (Saint-Etienne), Cartier Régine (Lyon), Oris Charlotte (ClermontFerrand), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
History, Professional Practice/organization & administration/standards/trends, SARS-CoV-2, [SDV]Life Sciences [q-bio], Biochemistry/*organization & administration/standards, medical biology, Pneumonia, France/epidemiology, biological markers, 21st Century, Disease Outbreaks, Scientific/*organization & administration/standards, Viral/blood/*diagnosis/epidemiology, covid-19, Community Networks/organization & administration/standards/trends, Coronavirus Infections/blood/*diagnosis/epidemiology, Videoconferencing/organization & administration/standards, Clinical Laboratory Services/*organization & administration/standards, Humans, Betacoronavirus/isolation & purification/pathogenicity, Covid-19, Societies, Pandemics, Biomarkers/*analysis/blood, Intersectoral Collaboration
Abstract

International audience; The SARS-CoV-2 virus is responsible for an epidemic disease called COVID-19, which was initially evidenced in Wuhan, China, and spread very rapidly in China and around the world. In France, the first isolated case seems now to be reported in December 2019, stage 3 of the COVID-19 epidemic was triggered on March 14(th), the start of the planned containment exit from May 11(th). Healthcare services have faced a large influx of patients who may be beyond their capacity to receive and care, particularly in the Large-East and Ile-de-France regions. Some patients show an evolution of the disease never observed before with other coronaviruses and develop in a few days a very important inflammatory reaction, which can lead to death of patients. A working group of the French Society of Clinical Biology (SFBC) was set up with the objective of providing updated information on the current status of the biological prescriptions (focusing on biochemistry ones) and their evolution during the epidemic, and of analyzing the biological parameters associated with comorbidities and patient evolution in order to link biological results with medical events. The expanded working group covers all sectors of medical biology in France and extends to the French-speaking world: hospital sectors (CHU and CH, Army Training Hospitals) and the private sector opening a field of view on the biological situation in establishments for dependent elderly, social establishments and clinical medical institutions. The purpose of this article is the presentation of this working group and its immediate and future actions.; Le virus SARS-CoV-2 est responsable d’une maladie épidémique dénommée COVID-19 initialement mise en évidence à Wuhan (Chine) et qui s’est propagée très rapidement en Chine puis dans le monde entier. En France, le premier cas isolé semble être signalé dès la fin du mois de décembre2019, le stade 3 de l’épidémie a été déclenché le 14 mars 2020 et la sortie progressive du confinement est prévue à partir du 11 mai 2020. Les services de soins ont fait face à un afflux massif de patients pouvant déborder leurs capacités d’accueil et de prise en charge, notamment dans les régions Grand-Est et Ile-de-France. Certains patients présentent une évolution de la maladie encore jamais observée avec les coronavirus et développent en quelques jours une réaction inflammatoire très importante, pouvant mener au décès. Un groupe de travail de la Société française de biologie clinique (SFBC) s’est constitué, ayant pour objectif de faire le point sur les prescriptions biologiques et leur évolution au cours de l’épidémie, d’analyser les paramètres biologiques, avec un focus biochimique, associés aux comorbidités et à l’évolution du patient, dans le but de relier les résultats biologiques avec des évènements du parcours de soins du patient. Ce groupe de travail recouvre tous les secteurs publics (CHU, CH, Hôpitaux d’instruction des armées) et privés de la biologie médicale en France métropolitaine et ultra-marine ; il s’étend également à la francophonie. Il permet une vision large sur la situation biologique en milieu hospitalier, établissements d’hébergements de personnes âgées dépendantes (Ehpad), établissements médicaux sociaux (EMS) et en cliniques. Le but de cet article est la présentation de ce groupe de travail et ses actions immédiates et à venir.

Published
2020

43. [Biological diagnosis of pheochromocytoma: is there an interest in urinary metanephrines measurement over 3 consecutive days?]

Author

Bettacchioli É, Leven C, Thuillier P, Plée-Gautier E, Lapègue M, Carré JL, and Padelli M

Subjects
Adrenal Gland Neoplasms urine, Aged, Female, Humans, Male, Metanephrine analysis, Middle Aged, Pheochromocytoma urine, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Time Factors, Urinalysis standards, Adrenal Gland Neoplasms diagnosis, Diagnostic Techniques, Endocrine standards, Metanephrine urine, Pheochromocytoma diagnosis, Urinalysis methods
Abstract

Pheochromocytoma and paraganglioma are neuroendocrine tumors characterized by a catecholamine production potential. The biochemical diagnosis for this type of tumor is carried out through the metanephrine titration on 24-hours urines. Some authors have suggested that the sensitivity of the test could be improved by sampling and analyzing urines 3 days in a row (cycle) versus a unique measurement but this method has never been fully evaluated. The goal of this study was to establish a comparison of diagnosis performances between urinary metanephrines measurement for 3 consecutive days, and metanephrines measurement on a unique 24-hour sample. Patients of Brest Regional University Hospital whose 3-consecutive day 24-hour urine samples had been analyzed from January 2011 to May 2017 were included in this study. The primary endpoint was the comparison of diagnostic performances of urinary metanephrine titration over a single day versus 3 consecutive days. Eighty-two patients for a total of 103 cycles among which 7 revealed a pheochromocytoma were analyzed. ROC curve analysis shows that the metanephrine cycle titration method is more efficient than the metanephrine single titration method (metanephrine: AUC=0.881 against 0.826 respectively; normetanephrine: AUC=0.946 against 0.901 respectively). Urinary titration over 3 days allows the diagnosis of 100% (7/7) of pheochromocytomas against 85.7% (6/7) for the the single urinary titration. In conclusion, metanephrine titration over 3 consecutive days of 24-hours urine samples shows a better sensitivity and better diagnosis performances for detecting pheochromocytoma and paraganglioma than the single titration method.

Published
2018
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