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2. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Steinmetz, J, Seeher, K, Schiess, N, Nichols, E, Cao, B, Servili, C, Cavallera, V, Cousin, E, Hagins, H, Moberg, M, Mehlman, M, Abate, Y, Abbas, J, Abbasi, M, Abbasian, M, Abbastabar, H, Abdelmasseh, M, Abdollahi, M, Abdollahifar, M, Abd-Rabu, R, Abdulah, D, Abdullahi, A, Abedi, A, Abedi, V, Abeldano Zuniga, R, Abidi, H, Abiodun, O, Aboagye, R, Abolhassani, H, Aboyans, V, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Aburuz, S, Adamu, L, Addo, I, Adebayo, O, Adekanmbi, V, Adekiya, T, Adikusuma, W, Adnani, Q, Adra, S, Afework, T, Afolabi, A, Afraz, A, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, S, Ahmadzade, A, Ahmed, A, Ahmed, H, Ahmed, J, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akade, S, Akbari, M, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemi, R, Akonde, M, Al Hasan, S, Alahdab, F, Al-Ahdal, T, Al-Amer, R, Albashtawy, M, Albataineh, M, Aldawsari, K, Alemi, H, Alemi, S, Algammal, A, Al-Gheethi, A, Alhalaiqa, F, Alhassan, R, Ali, A, Ali, E, Ali, L, Ali, M, Ali, R, Ali, S, Shujait Ali, S, Ali, Z, Alif, S, Alimohamadi, Y, Aliyi, A, Aljofan, M, Aljunid, S, Alladi, S, Almazan, J, Almustanyir, S, Al-Omari, B, Alqahtani, J, Alqasmi, I, Alqutaibi, A, Al-Shahi Salman, R, Altaany, Z, Al-Tawfiq, J, Altirkawi, K, Alvis-Guzman, N, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Amani, R, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Amusa, G, Amzat, J, Ancuceanu, R, Anderlini, D, Anderson, D, Andrei, C, Androudi, S, Angappan, D, Angesom, T, Anil, A, Ansari-Moghaddam, A, Anwer, R, Arafat, M, Aravkin, A, Areda, D, Ariffin, H, Arifin, H, Arkew, M, Arnlov, J, Arooj, M, Artamonov, A, Artanti, K, Aruleba, R, Asadi-Pooya, A, Asena, T, Asghari-Jafarabadi, M, Ashraf, M, Ashraf, T, Atalell, K, Athari, S, Atinafu, B, Atorkey, P, Atout, M, Atreya, A, Aujayeb, A, Avan, A, Ayala Quintanilla, B, Ayatollahi, H, Ayinde, O, Mohammad Ayyoubzadeh, S, Azadnajafabad, S, Azizi, Z, Azizian, K, Azzam, A, Babaei, M, Badar, M, Badiye, A, Baghdadi, S, Bagherieh, S, Bai, R, Baig, A, Balakrishnan, S, Balalla, S, Baltatu, O, Banach, M, Bandyopadhyay, S, Banerjee, I, Baran, M, Barboza, M, Barchitta, M, Bardhan, M, Barker-Collo, S, Barnighausen, T, Barrow, A, Bashash, D, Bashiri, H, Bashiru, H, Basiru, A, Basso, J, Basu, S, Batiha, A, Batra, K, Baune, B, Bedi, N, Begde, A, Begum, T, Behnam, B, Behnoush, A, Beiranvand, M, Bejot, Y, Bekele, A, Belete, M, Belgaumi, U, Bemanalizadeh, M, Bender, R, Benfor, B, Bennett, D, Bensenor, I, Berice, B, Bettencourt, P, Beyene, K, Bhadra, A, Bhagat, D, Bhangdia, K, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, A, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, R, Bijani, A, Bikbov, B, Bilalaga, M, Biswas, A, Bitaraf, S, Bitra, V, Bjorge, T, Bodolica, V, Bodunrin, A, Boloor, A, Braithwaite, D, Brayne, C, Brenner, H, Briko, A, Bringas Vega, M, Brown, J, Budke, C, Buonsenso, D, Burkart, K, Burns, R, Bustanji, Y, Butt, M, Butt, N, Butt, Z, Cabral, L, dos Santos, F, Calina, D, Campos-Nonato, I, Cao, C, Carabin, H, Cardenas, R, Carreras, G, Carvalho, A, Castaneda-Orjuela, C, Casulli, A, Catala-Lopez, F, Catapano, A, Caye, A, Cegolon, L, Cenderadewi, M, Cerin, E, Chacon-Uscamaita, P, Chan, J, Chanie, G, Charan, J, Chattu, V, Chekol Abebe, E, Chen, H, Chen, J, Chi, G, Chichagi, F, Chidambaram, S, Chimoriya, R, Ching, P, Chitheer, A, Chong, Y, Chopra, H, Choudhari, S, Chowdhury, E, Chowdhury, R, Christensen, H, Chu, D, Chukwu, I, Chung, E, Coberly, K, Columbus, A, Comachio, J, Conde, J, Cortesi, P, Costa, V, Couto, R, Criqui, M, Cruz-Martins, N, Dabbagh Ohadi, M, Dadana, S, Dadras, O, Dai, X, Dai, Z, D'Amico, E, Danawi, H, Dandona, L, Dandona, R, Darwish, A, Das, S, Dascalu, A, Dash, N, Dashti, M, De la Hoz, F, de la Torre-Luque, A, De Leo, D, Dean, F, Dehghan, A, Dejene, H, Demant, D, Demetriades, A, Demissie, S, Deng, X, Desai, H, Devanbu, V, Dhama, K, Dharmaratne, S, Dhimal, M, Dias da Silva, D, Diaz, D, Dibas, M, Ding, D, Dinu, M, Dirac, M, Diress, M, Do, T, Doan, K, Dodangeh, M, Doheim, M, Dokova, K, Dongarwar, D, Dsouza, H, Dube, J, Duraisamy, S, Durojaiye, O, Dutta, S, Dziedzic, A, Edinur, H, Eissazade, N, Ekholuenetale, M, Ekundayo, T, El Nahas, N, El Sayed, I, Elahi Najafi, M, Elbarazi, I, Elemam, N, Elgar, F, Elgendy, I, Elhabashy, H, Elhadi, M, Elilo, L, Ellenbogen, R, Elmeligy, O, Elmonem, M, Elshaer, M, Elsohaby, I, Emamverdi, M, Emeto, T, Endres, M, Esezobor, C, Eskandarieh, S, Fadaei, A, Fagbamigbe, A, Fahim, A, Faramarzi, A, Fares, J, Farjoud Kouhanjani, M, Faro, A, Farzadfar, F, Fatehizadeh, A, Fathi, M, Fathi, S, Fatima, S, Feizkhah, A, Fereshtehnejad, S, Ferrari, A, Ferreira, N, Fetensa, G, Firouraghi, N, Fischer, F, Fonseca, A, Force, L, Fornari, A, Foroutan, B, Fukumoto, T, Gadanya, M, Gaidhane, A, Galali, Y, Galehdar, N, Gan, Q, Gandhi, A, Ganesan, B, Gardner, W, Garg, N, Gau, S, Gautam, R, Gebre, T, Gebrehiwot, M, Gebremeskel, G, Gebreslassie, H, Getacher, L, Ghaderi Yazdi, B, Ghadirian, F, Ghaffarpasand, F, Ghanbari, R, Ghasemi, M, Ghazy, R, Ghimire, S, Gholami, A, Gholamrezanezhad, A, Ghotbi, E, Ghozy, S, Gialluisi, A, Gill, P, Glasstetter, L, Gnedovskaya, E, Golchin, A, Golechha, M, Goleij, P, Golinelli, D, Gomes-Neto, M, Goulart, A, Goyal, A, Gray, R, Grivna, M, Guadie, H, Guan, B, Guarducci, G, Guicciardi, S, Gunawardane, D, Guo, H, Gupta, B, Gupta, R, Gupta, S, Gupta, V, Gutierrez, R, Habibzadeh, F, Hachinski, V, Haddadi, R, Hadei, M, Hadi, N, Haep, N, Haile, T, Haj-Mirzaian, A, Hall, B, Halwani, R, Hameed, S, Hamiduzzaman, M, Hammoud, A, Han, H, Hanifi, N, Hankey, G, Hannan, M, Hao, J, Harapan, H, Hareru, H, Hargono, A, Harlianto, N, Haro, J, Hartman, N, Hasaballah, A, Hasan, F, Hasani, H, Hasanian, M, Hassan, A, Hassan, S, Hassanipour, S, Hassankhani, H, Hassen, M, Haubold, J, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Heidari, M, Heidari-Soureshjani, R, Hesami, H, Hezam, K, Hiraike, Y, Hoffman, H, Holla, R, Hopf, K, Horita, N, Hossain, M, Hossain, S, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, S, Hu, C, Huang, J, Huda, M, Hussain, J, Hussein, N, Huynh, H, Hwang, B, Ibitoye, S, Ilaghi, M, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Iravanpour, F, Islam, S, Ismail, F, Iso, H, Isola, G, Iwagami, M, Iwu, C, Iyer, M, Jaan, A, Jacob, L, Jadidi-Niaragh, F, Jafari, M, Jafarinia, M, Jafarzadeh, A, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jaiswal, A, Jakovljevic, M, Jamora, R, Jana, S, Javadi, N, Javed, S, Javeed, S, Jayapal, S, Jayaram, S, Jiang, H, Johnson, C, Johnson, W, Jokar, M, Jonas, J, Joseph, A, Joseph, N, Joshua, C, Jurisson, M, Kabir, A, Kabir, Z, Kabito, G, Kadashetti, V, Kafi, F, Kalani, R, Kalantar, F, Kaliyadan, F, Kamath, A, Kamath, S, Kanchan, T, Kandel, A, Kandel, H, Kanmodi, K, Karajizadeh, M, Karami, J, Karanth, S, Karaye, I, Karch, A, Karimi, A, Karimi, H, Karimi Behnagh, A, Kasraei, H, Kassebaum, N, Kauppila, J, Kaur, H, Kaur, N, Kayode, G, Kazemi, F, Keikavoosi-Arani, L, Keller, C, Keykhaei, M, Khadembashiri, M, Khader, Y, Khafaie, M, Khajuria, H, Khalaji, A, Khamesipour, F, Khammarnia, M, Khan, M, Khan, Y, Suheb, M, Khanmohammadi, S, Khanna, T, Khatab, K, Khatatbeh, H, Khatatbeh, M, Khateri, S, Khatib, M, Khayat Kashani, H, Khonji, M, Khorashadizadeh, F, Khormali, M, Khubchandani, J, Kian, S, Kim, G, Kim, J, Kim, M, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kivimaki, M, Kochhar, S, Kolahi, A, Koly, K, Kompani, F, Koroshetz, W, Kosen, S, Kourosh Arami, M, Koyanagi, A, Kravchenko, M, Krishan, K, Krishnamoorthy, V, Defo, B, Kuddus, M, Kumar, A, Kumar, G, Kumar, M, Kumar, N, Kumsa, N, Kundu, S, Kurniasari, M, Kusuma, D, Kuttikkattu, A, Kyu, H, La Vecchia, C, Ladan, M, Lahariya, C, Laksono, T, Lal, D, Lallukka, T, Lam, J, Lami, F, Landires, I, Langguth, B, Lasrado, S, Latief, K, Latifinaibin, K, Lau, K, Laurens, M, Lawal, B, Le, L, Le, T, Ledda, C, Lee, M, Lee, S, Lee, W, Lee, Y, Leonardi, M, Lerango, T, Li, M, Li, W, Ligade, V, Lim, S, Linehan, C, Liu, C, Liu, J, Liu, W, Lo, C, Lo, W, Lobo, S, Logroscino, G, Lopes, G, Lopukhov, P, Lorenzovici, L, Lorkowski, S, Loureiro, J, Lubinda, J, Lucchetti, G, Saute, R, Ma, Z, Mabrok, M, Machoy, M, Madadizadeh, F, El Razek, M, Maghazachi, A, Maghbouli, N, Mahjoub, S, Mahmoudi, M, Majeed, A, Malagon-Rojas, J, Malakan Rad, E, Malhotra, K, Malik, A, Malik, I, Mallhi, T, Malta, D, Manilal, A, Mansouri, V, Mansournia, M, Marasini, B, Marateb, H, Maroufi, S, Martinez-Raga, J, Martini, S, Martins-Melo, F, Martorell, M, Marz, W, Marzo, R, Massano, J, Mathangasinghe, Y, Mathews, E, Maude, R, Maugeri, A, Maulik, P, Mayeli, M, Mazaheri, M, Mcalinden, C, Mcgrath, J, Meena, J, Mehndiratta, M, Mendez-Lopez, M, Mendoza, W, Mendoza-Cano, O, Menezes, R, Merati, M, Meretoja, A, Merkin, A, Mersha, A, Mestrovic, T, Mi, T, Miazgowski, T, Michalek, I, Mihretie, E, Minh, L, Mirfakhraie, R, Mirica, A, Mirrakhimov, E, Mirzaei, M, Misganaw, A, Misra, S, Mithra, P, Mizana, B, Mohamadkhani, A, Mohamed, N, Mohammadi, E, Mohammadi, H, Mohammadi, S, Mohammadshahi, M, Mohammed, M, Mohammed, S, Mohan, S, Mojiri-Forushani, H, Moka, N, Mokdad, A, Molinaro, S, Moller, H, Monasta, L, Moniruzzaman, M, Montazeri, F, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moraga, P, Morovatdar, N, Morrison, S, Mosapour, A, Mosser, J, Mossialos, E, Motaghinejad, M, Mousavi, P, Ehsan Mousavi, S, Mubarik, S, Muccioli, L, Mughal, F, Mukoro, G, Mulita, A, Mulita, F, Musaigwa, F, Mustafa, A, Mustafa, G, Muthu, S, Nagarajan, A, Naghavi, P, Naik, G, Nainu, F, Nair, T, Najmuldeen, H, Nakhostin Ansari, N, Nambi, G, Namdar Areshtanab, H, Nargus, S, Nascimento, B, Naser, A, Nashwan, A, Nasoori, H, Nasreldein, A, Natto, Z, Nauman, J, Nayak, B, Nazri-Panjaki, A, Negaresh, M, Negash, H, Negoi, I, Negoi, R, Negru, S, Nejadghaderi, S, Nematollahi, M, Nesbit, O, Newton, C, Nguyen, D, Nguyen, H, Nguyen, N, Nguyen, P, Nguyen, V, Niazi, R, Nikolouzakis, T, Niranjan, V, Nnyanzi, L, Noman, E, Noroozi, N, Norrving, B, Noubiap, J, Nri-Ezedi, C, Ntaios, G, Nunez-Samudio, V, Nurrika, D, Oancea, B, Odetokun, I, O'Donnell, M, Ogunsakin, R, Oguta, J, Oh, I, Okati-Aliabad, H, Okeke, S, Okekunle, A, Okonji, O, Okwute, P, Olagunju, A, Olaiya, M, Olana, M, Olatubi, M, Oliveira, G, Olufadewa, I, Olusanya, B, Bali, A, Ong, S, Onwujekwe, O, Ordak, M, Orji, A, Ortega-Altamirano, D, Osuagwu, U, Otstavnov, N, Otstavnov, S, Ouyahia, A, Owolabi, M, Mahesh Padukudru, P, Pacheco-Barrios, K, Padubidri, J, Pal, P, Palange, P, Palladino, C, Palladino, R, Palma-Alvarez, R, Pan, F, Panagiotakos, D, Panda-Jonas, S, Pandey, A, Pandian, J, Pangaribuan, H, Pantazopoulos, I, Pardhan, S, Parija, P, Parikh, R, Park, S, Parthasarathi, A, Pashaei, A, Patel, J, Patil, S, Patoulias, D, Pawar, S, Pedersini, P, Pensato, U, Pereira, D, Pereira, J, Pereira, M, Peres, M, Perico, N, Perna, S, Petcu, I, Petermann-Rocha, F, Pham, H, Phillips, M, Pinilla-Monsalve, G, Piradov, M, Plotnikov, E, Poddighe, D, Polat, B, Poluru, R, Pond, C, Poudel, G, Pouramini, A, Pourbagher-Shahri, A, Pourfridoni, M, Pourtaheri, N, Prakash, P, Prakash, S, Prakash, V, Prates, E, Pritchett, N, Purnobasuki, H, Qasim, N, Qattea, I, Qian, G, Radhakrishnan, V, Raee, P, Shahraki, H, Rafique, I, Raggi, A, Raghav, P, Rahati, M, Rahim, F, Rahimi, Z, Rahimifard, M, Rahman, M, Rahmani, A, Rahmani, S, Youshanlouei, H, Rahmati, M, Raj Moolambally, S, Rajabpour-Sanati, A, Ramadan, H, Ramasamy, S, Ramasubramani, P, Ramazanu, S, Rancic, N, Rao, I, Rao, S, Rapaka, D, Rashedi, V, Rashid, A, Rashidi, M, Rashidi Alavijeh, M, Rasouli-Saravani, A, Rawaf, S, Razo, C, Redwan, E, Bana, A, Remuzzi, G, Rezaei, N, Rezaeian, M, Rhee, T, Riad, A, Robinson, S, Rodrigues, M, Rodriguez, J, Roever, L, Rogowski, E, Romoli, M, Ronfani, L, Roy, P, Pramanik, K, Rubagotti, E, Ruiz, M, Russ, T, Sunnerhagen, K, Saad, A, Saadatian, Z, Saber, K, Saberikamarposhti, M, Sacco, S, Saddik, B, Sadeghi, E, Sadeghian, S, Saeed, U, Safdarian, M, Safi, S, Sagar, R, Sagoe, D, Saheb Sharif-Askari, F, Saheb Sharif-Askari, N, Sahebkar, A, Sahoo, S, Sahraian, M, Sajedi, S, Sakshaug, J, Saleh, M, Salehi Omran, H, Salem, M, Salimi, S, Samadi Kafil, H, Samadzadeh, S, Samargandy, S, Samodra, Y, Samuel, V, Samy, A, Sanadgol, N, Sanjeev, R, Sanmarchi, F, Santomauro, D, Santri, I, Santric-Milicevic, M, Saravanan, A, Sarveazad, A, Satpathy, M, Saylan, M, Sayyah, M, Scarmeas, N, Schlaich, M, Schuermans, A, Schwarzinger, M, Schwebel, D, Selvaraj, S, Sendekie, A, Sengupta, P, Senthilkumaran, S, Serban, D, Sergindo, M, Sethi, Y, Seyedalinaghi, S, Seylani, A, Shabani, M, Shabany, M, Shafie, M, Shahabi, S, Shahbandi, A, Shahid, S, Shahraki-Sanavi, F, Shahsavari, H, Shahwan, M, Shaikh, M, Shaji, K, Sham, S, Shama, A, Shamim, M, Shams-Beyranvand, M, Shamsi, M, Shanawaz, M, Sharath, M, Sharfaei, S, Sharifan, A, Sharma, M, Sharma, R, Shashamo, B, Shayan, M, Sheikhi, R, Shekhar, S, Shen, J, Shenoy, S, Shetty, P, Shiferaw, D, Shigematsu, M, Shiri, R, Shittu, A, Shivakumar, K, Shokri, F, Shool, S, Shorofi, S, Shrestha, S, Siankam Tankwanchi, A, Siddig, E, Sigfusdottir, I, Silva, J, Silva, L, Sinaei, E, Singh, B, Singh, G, Singh, P, Singh, S, Sirota, S, Sivakumar, S, Sohag, A, Solanki, R, Soleimani, H, Solikhah, S, Solomon, Y, Song, S, Song, Y, Sotoudeh, H, Spartalis, M, Stark, B, Starnes, J, Starodubova, A, Stein, D, Steiner, T, Stovner, L, Suleman, M, Abdulkader, R, Sultana, A, Sun, J, Sunkersing, D, Sunny, A, Susianti, H, Swain, C, Szeto, M, Tabares-Seisdedos, R, Tabatabaei, S, Tabatabai, S, Tabish, M, Taheri, M, Tahvildari, A, Tajbakhsh, A, Tampa, M, Lukenze Tamuzi, J, Tan, K, Tang, H, Tareke, M, Tarigan, I, Tat, N, Tat, V, Tavakoli Oliaee, R, Tavangar, S, Tavasol, A, Tefera, Y, Tehrani-Banihashemi, A, Temesgen, W, Temsah, M, Teramoto, M, Tesfaye, A, Tesfaye, E, Tesler, R, Thakali, O, Thangaraju, P, Thapa, R, Thapar, R, Thomas, N, Thrift, A, Ticoalu, J, Tillawi, T, Toghroli, R, Tonelli, M, Tovani-Palone, M, Traini, E, Tran, N, Van Tran, P, Tromans, S, Truelsen, T, Truyen, T, Tsatsakis, A, Tsegay, G, Tsermpini, E, Tualeka, A, Tufa, D, Ubah, C, Udoakang, A, Ulhaq, I, Umair, M, Umakanthan, S, Umapathi, K, Unim, B, Unnikrishnan, B, Vaithinathan, A, Vakilian, A, Tahbaz, S, Valizadeh, R, Van den Eynde, J, Vart, P, Varthya, S, Vasankari, T, Vaziri, S, Vellingiri, B, Venketasubramanian, N, Verras, G, Vervoort, D, Villafane, J, Villani, L, Veloz, A, Viskadourou, M, Vladimirov, S, Vlassov, V, Volovat, S, Vu, L, Vujcic, I, Wagaye, B, Waheed, Y, Wahood, W, Walde, M, Wang, F, Wang, S, Wang, Y, Waqas, M, Waris, A, Weerakoon, K, Weintraub, R, Weldemariam, A, Westerman, R, Whisnant, J, Wickramasinghe, D, Wickramasinghe, N, Willekens, B, Wilner, L, Winkler, A, Wolfe, C, Wu, A, Wulf Hanson, S, Xu, S, Xu, X, Yadollahpour, A, Yaghoubi, S, Yahya, G, Yamagishi, K, Yang, L, Yano, Y, Yao, Y, Yehualashet, S, Yeshaneh, A, Yesiltepe, M, Yi, S, Yigit, A, Yigit, V, Yon, D, Yonemoto, N, You, Y, Younis, M, Yu, C, Yusuf, H, Zadey, S, Zahedi, M, Zakham, F, Zaki, N, Zali, A, Zamagni, G, Zand, R, Zandieh, G, Zangiabadian, M, Zarghami, A, Zastrozhin, M, Zeariya, M, Zegeye, Z, Zeukeng, F, Zhai, C, Zhang, C, Zhang, H, Zhang, Y, Zhang, Z, Zhao, H, Zhao, Y, Zheng, P, Zhou, H, Zhu, B, Zhumagaliuly, A, Zielinska, M, Zikarg, Y, Zoladl, M, Murray, C, Ong, K, Feigin, V, Vos, T, Dua, T, Steinmetz J. D., Seeher K. M., Schiess N., Nichols E., Cao B., Servili C., Cavallera V., Cousin E., Hagins H., Moberg M. E., Mehlman M. L., Abate Y. H., Abbas J., Abbasi M. A., Abbasian M., Abbastabar H., Abdelmasseh M., Abdollahi M., Abdollahifar M. -A., Abd-Rabu R., Abdulah D. M., Abdullahi A., Abedi A., Abedi V., Abeldano Zuniga R. A., Abidi H., Abiodun O., Aboagye R. G., Abolhassani H., Aboyans V., Abrha W. A., Abualhasan A., Abu-Gharbieh E., Aburuz S., Adamu L. H., Addo I. Y., Adebayo O. M., Adekanmbi V., Adekiya T. A., Adikusuma W., Adnani Q. E. S., Adra S., Afework T., Afolabi A. A., Afraz A., Afzal S., Aghamiri S., Agodi A., Agyemang-Duah W., Ahinkorah B. O., Ahmad A., Ahmad D., Ahmad S., Ahmadzade A. M., Ahmed A., Ahmed H., Ahmed J. Q., Ahmed L. A., Ahmed M. B., Ahmed S. A., Ajami M., Aji B., Ajumobi O., Akade S., Akbari M., Akbarialiabad H., Akhlaghi S., Akinosoglou K., Akinyemi R. O., Akonde M., Al Hasan S. M., Alahdab F., Al-Ahdal T. M. A., Al-Amer R. M., Albashtawy M., AlBataineh M. 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N., Mirfakhraie R., Mirica A., Mirrakhimov E. M., Mirzaei M., Misganaw A., Misra S., Mithra P., Mizana B. A., Mohamadkhani A., Mohamed N. S., Mohammadi E., Mohammadi H., Mohammadi S., Mohammadshahi M., Mohammed M., Mohammed S., Mohan S., Mojiri-Forushani H., Moka N., Mokdad A. H., Molinaro S., Moller H., Monasta L., Moniruzzaman M., Montazeri F., Moradi M., Moradi Y., Moradi-Lakeh M., Moraga P., Morovatdar N., Morrison S. D., Mosapour A., Mosser J. F., Mossialos E., Motaghinejad M., Mousavi P., Ehsan Mousavi S., Mubarik S., Muccioli L., Mughal F., Mukoro G. D., Mulita A., Mulita F., Musaigwa F., Mustafa A., Mustafa G., Muthu S., Nagarajan A. J., Naghavi P., Naik G. R., Nainu F., Nair T. S., Najmuldeen H. H. R., Nakhostin Ansari N., Nambi G., Namdar Areshtanab H., Nargus S., Nascimento B. R., Naser A. Y., Nashwan A. J. J., Nasoori H., Nasreldein A., Natto Z. S., Nauman J., Nayak B. P., Nazri-Panjaki A., Negaresh M., Negash H., Negoi I., Negoi R. I., Negru S. M., Nejadghaderi S. A., Nematollahi M. H., Nesbit O. D., Newton C. R. J., Nguyen D. H., Nguyen H. T. H., Nguyen H. Q., Nguyen N. -T. T., Nguyen P. T., Nguyen V. T., Niazi R. K., Nikolouzakis T. K., Niranjan V., Nnyanzi L. A., Noman E. A., Noroozi N., Norrving B., Noubiap J. J., Nri-Ezedi C. A., Ntaios G., Nunez-Samudio V., Nurrika D., Oancea B., Odetokun I. A., O'Donnell M. J., Ogunsakin R. E., Oguta J. O., Oh I. -H., Okati-Aliabad H., Okeke S. R., Okekunle A. P., Okonji O. C., Okwute P. G., Olagunju A. T., Olaiya M. T., Olana M. D., Olatubi M. I., Oliveira G. M. M., Olufadewa I. I., Olusanya B. O., Bali A. O., Ong S., Onwujekwe O. E., Ordak M., Orji A. U., Ortega-Altamirano D. V., Osuagwu U. L., Otstavnov N., Otstavnov S. S., Ouyahia A., Owolabi M. O., Mahesh Padukudru P. A., Pacheco-Barrios K., Padubidri J. R., Pal P. K., Palange P. N., Palladino C., Palladino R., Palma-Alvarez R. F., Pan F., Panagiotakos D., Panda-Jonas S., Pandey A., Pandian J. D., Pangaribuan H. 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- Abstract
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous s
- Published
- 2024
3. Efficacy and safety of antiparasitic therapy for neurocysticercosis in rural Tanzania:a prospective cohort study
- Author
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Stelzle, D., Makasi, C., Schmidt, V., Trevisan, C., Van Damme, I., Ruether, C., Dorny, P., Magnussen, P., Zulu, G., Mwape, K. E., Bottieau, E., Prazeres da Costa, C., Prodjinotho, U. F., Carabin, H., Jackson, E., Fleury, A., Gabriel, S., Ngowi, B. J., Winkler, A. S., Stelzle, D., Makasi, C., Schmidt, V., Trevisan, C., Van Damme, I., Ruether, C., Dorny, P., Magnussen, P., Zulu, G., Mwape, K. E., Bottieau, E., Prazeres da Costa, C., Prodjinotho, U. F., Carabin, H., Jackson, E., Fleury, A., Gabriel, S., Ngowi, B. J., and Winkler, A. S.
- Abstract
PurposeNeurocysticercosis is common in regions endemic for Taenia solium. Active-stage neurocysticercosis can be treated with antiparasitic medication, but so far no study on efficacy and safety has been conducted in Africa.MethodsWe conducted a prospective cohort study on treatment of neurocysticercosis in Tanzania between August 2018 and January 2022. Patients were initially treated with albendazole (15 mg/kg/d) for 10 days and followed up for 6 months. Additionally in July 2021, all participants who then still had cysts were offered a combination therapy consisting of albendazole (15 mg/kg/d) and praziquantel (50 mg/kg/d). Antiparasitic treatment was accompanied by corticosteroid medication and anti-seizure medication if the patient had experienced epileptic seizures before treatment.ResultsSixty-three patients were recruited for this study, of whom 17 had a complete follow-up after albendazole monotherapy. These patients had a total of 138 cysts at baseline, of which 58 (42%) had disappeared or calcified by the end of follow-up. The median cyst reduction was 40% (interquartile range 11-63%). Frequency of epileptic seizures reduced considerably (p < 0.001). Three patients had all active cysts resolved or calcified and of the remaining 14, eight received the combination therapy which resolved 63 of 66 cysts (95%). Adverse events were infrequent and mild to moderate during both treatment cycles.ConclusionCyst resolution was unsatisfactory with albendazole monotherapy but was very high when it was followed by a combination of albendazole and praziquantel.
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- 2023
4. Schistosoma japonicum in Samar, the Philippines : infection in dogs and rats as a possible risk factor for human infection
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CARABIN, H., McGARVEY, S. T., SAHLU, I., TARAFDER, M. R., JOSEPH, L., DE ANDRADE, B. B., BALOLONG, E., and OLVEDA, R.
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- 2015
5. 311 - Détermination des facteurs de confusion avec les DAGs: l'exemple de Taenia solium
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Jackson, E., primary, Dermauw, V., additional, Tchamdja, G., additional, Jalal, M. Shah, additional, Janitz, A., additional, Millogo, A., additional, Tarnagda, Z., additional, Ganaba, R., additional, Dorny, P., additional, and Carabin, H., additional
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- 2022
- Full Text
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6. 465 - Étude des canaux de communication « Une Seule Santé » lors d'un cas humain d'Influenza porcin
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Denis-Robichaud, J., primary, Mutabazi, J.-C., additional, D'Astous, M., additional, Nswal, N., additional, Osborn, A., additional, Hindmarch, S., additional, Zarowsky, C., additional, Rees, E., additional, and Carabin, H., additional
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- 2022
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7. Development and validation of a multiplexed-tandem qPCR tool for diagnostics of human soil-transmitted helminth infections
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Carabin, H, Stracke, K, Clarke, N, Awburn, CV, Nery, SV, Khieu, V, Traub, RJ, Jex, AR, Carabin, H, Stracke, K, Clarke, N, Awburn, CV, Nery, SV, Khieu, V, Traub, RJ, and Jex, AR
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Soil-transmitted helminths (STH) are a major cause of morbidity in tropical developing countries with a global infection prevalence of more than one billion people and disease burden of around 3.4 million disability adjusted life years. Infection prevalence directly correlates to inadequate sanitation, impoverished conditions and limited access to public health systems. Underestimation of infection prevalence using traditional microscopy-based diagnostic techniques is common, specifically in populations with access to benzimidazole mass treatment programs and a predominance of low intensity infections. In this study, we developed a multiplexed-tandem qPCR (MT-PCR) tool to identify and quantify STH eggs in stool samples. We have assessed this assay by measuring infection prevalence and intensity in field samples of two cohorts of participants from Timor-Leste and Cambodia, which were collected as part of earlier epidemiological studies. MT-PCR diagnostic parameters were compared to a previously published multiplexed qPCR for STH detection. The MT-PCR assay agreed strongly with qPCR data and showed a diagnostic specificity of 99.60–100.00% (sensitivity of 83.33–100.00%) compared to qPCR and kappa agreement exceeding 0.85 in all tests. In addition, the MT-PCR has the added advantage of distinguishing Ancylostoma spp. species, namely Ancylostoma duodenale and Ancylostoma ceylanicum. This semi-automated platform uses a standardized, manufactured reagent kit, shows excellent run-to-run consistency/repeatability and supports high-throughput detection and quantitation at a moderate cost.
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- 2019
8. 3-4 - « Vive les masques » ou « A bas les masques » ? Quand un algorithme a du mal à classer les sentiments
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Denis-Robichaud, J., Niu, J., Rees, E., and Carabin, H.
- Abstract
Il a été suggéré que les données provenant de médias sociaux pourraient être utilisées pour évaluer l'acceptation des mesures de santé publique (MSP) par la population. L'objectif de cette étude vise à évaluer la capacité d'algorithmes à identifier les sujets et les sentiments de gazouillis relatifs aux MSP.
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- 2024
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9. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
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Feigin, VL, Abajobir, AA, Abate, KH, Abd-Allah, F, Abdulle, AM, Abera, SF, Abyu, GY, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akinyemi, RO, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, AT, Ansari, H, Anwari, P, Arnlov, J, Asayesh, H, Asgedom, SW, Atey, TM, Avila-Burgos, L, Avokpaho, EFGA, Azarpazhooh, MR, Barac, A, Barboza, M, Barker-Collo, SL, Baernighausen, T, Bedi, N, Beghi, E, Bennett, DA, Bensenor, IM, Berhane, A, Betsu, BD, Bhaumik, S, Birlik, SM, Biryukov, S, Boneya, DJ, Bulto, LN, Carabin, H, Casey, D, Castaneda-Orjuela, CA, Catala-Lopez, F, Chen, H, Chitheer, AA, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, deVeber, GA, Dharmaratne, SD, Do, HP, Dokova, K, Dorsey, ER, Ellenbogen, RG, Eskandarieh, S, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Foreman, KJ, Geleijnse, JM, Gillum, RF, Giussani, G, Goldberg, EM, Gona, PN, Goulart, AC, Gugnani, HC, Gupta, R, Hachinski, V, Hamadeh, RR, Hambisa, M, Hankey, GJ, Hareri, HA, Havmoeller, R, Hay, SI, Heydarpour, P, Hotez, PJ, Jakovljevic, MMB, Javanbakht, M, Jeemon, P, Jonas, JB, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khoja, AT, Khubchandani, J, Kulkarni, C, Kim, D, Kim, YJ, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, RV, Defo, BK, Kumar, GA, Kumar, R, Kyu, HH, Larsson, A, Lavados, PM, Li, Y, Liang, X, Liben, ML, Lo, WD, Logroscino, G, Lotufo, PA, Loy, CT, Mackay, MT, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, LG, Massano, J, Mazidi, M, McAlinden, C, Mehata, S, Mehndiratta, MM, Memish, ZA, Mendoza, W, Mengistie, MA, Mensah, GA, Meretoja, A, Mezgebe, HB, Miller, TR, Mishra, SR, Ibrahim, NM, Mohammadi, A, Mohammed, KE, Mohammed, S, Mokdad, AH, Moradi-Lakeh, M, Velasquez, IM, Musa, KI, Naghavi, M, Ngunjiri, JW, Nguyen, CT, Nguyen, G, Nguyen, QL, Nguyen, TH, Nichols, E, Ningrum, DN, Nong, VM, Norrving, B, Noubiap, JJN, Ogbo, FA, Owolabi, MO, Pandian, JD, Parmar, PG, Pereira, DM, Petzold, M, Phillips, MR, Piradov, MA, Poulton, RG, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rahman, MH, Rai, RK, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, AMN, Rezai, MS, Roth, GA, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, MA, Samy, AM, Santalucia, P, Santos, IS, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, MI, Sepanlou, SG, Shaikh, MA, Shakir, R, Shamsizadeh, M, Sheth, KN, Shigematsu, M, Shoman, H, Silva, DA, Smith, M, Sobngwi, E, Sposato, LA, Stanaway, JD, Stein, DJ, Steiner, TJ, Stovner, LJ, Abdulkader, RS, Szoeke, CEI, Tabares-Seisdedos, R, Tanne, D, Theadom, AM, Thrift, AG, Tirschwell, DL, Topor-Madry, R, Tran, BX, Truelsen, T, Tuem, KB, Ukwaja, KN, Uthman, OA, Varakin, YY, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Wadilo, F, Wakayo, T, Wallin, MT, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, CS, Woldu, MA, Wolfe, CDA, Xavier, D, Xu, G, Yano, Y, Yimam, HH, Yonemoto, N, Yu, C, Zaidi, Z, Zaki, MES, Zunt, JR, Murray, CJL, Vos, T, Disorders, GBDN, Feigin, V, Abajobir, A, Abate, K, Abd-Allah, F, Abdulle, A, Abera, S, Abyu, G, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, A, Ansari, H, Anwari, P, Ärnlöv, J, Asayesh, H, Asgedom, S, Atey, T, Avila-Burgos, L, Frinel, E, Avokpaho, G, Barac, A, Barboza, M, Barker-Collo, S, Bärnighausen, T, Bedi, N, Beghi, E, Bennett, D, Bensenor, I, Berhane, A, Betsu, B, Bhaumik, S, Birlik, S, Biryukov, S, Boneya, D, Bulto, L, Carabin, H, Casey, D, Castañeda-Orjuela, C, Catalá-López, F, Chen, H, Chitheer, A, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, Veber, G, Dharmaratne, S, Do, H, Dokova, K, Dorsey, E, Ellenbogen, R, Eskandarieh, S, Farvid, M, Fereshtehnejad, S, Fischer, F, Foreman, K, Geleijnse, J, Gillum, R, Giussani, G, Gona, P, Goulart, A, Gugnani, H, Gupta, R, Hamadeh, R, Hambisa, M, Hankey, G, Hareri, H, Havmoeller, R, Hay, S, Heydarpour, P, Hotez, P, Jakovljevic, M, Javanbakht, M, Jeemon, P, Jonas, J, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, P, Khader, Y, Khalil, I, Khan, E, Khang, Y, Tawfih, A, Khoja, A, Khubchandani, J, Kim, D, Kim, Y, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, R, Defo, B, Kumar, G, Kumar, R, Kyu, H, Larsson, A, Lavados, P, Li, Y, Liang, X, Liben, M, Lo, W, Logroscino, G, Lotufo, P, Loy, C, Mackay, M, El Razek, H, El Razek, M, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, L, Massano, J, Mazidi, M, Mcalinden, C, Mehata, S, Mehndiratta, M, Memish, Z, Mendoza, W, Mengistie, M, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mishra, S, Ibrahim, N, Mohammadi, A, Mohammed, K, Mohammed, S, Mokdad, A, Moradi-Lakeh, M, Velasquez, I, Musa, K, Naghavi, M, Ngunjiri, J, Nguyen, C, Nguyen, G, Le Nguyen, Q, Nguyen, T, Nichols, E, Ningrum, D, Nong, V, Norrving, B, Noubiap, J, Ogbo, F, Owolabi, M, Pandian, J, Petzold, M, Phillips, M, Piradov, M, Poulton, R, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rai, R, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, A, Rezai, M, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, M, Samy, A, Santalucia, P, Santos, I, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, M, Sepanlou, S, Shaikh, M, Shakir, R, Shamsizadeh, M, Sheth, K, Shigematsu, M, Shoman, H, Silva, D, Smith, M, Sobngwi, E, Sposato, L, Stein, D, Steiner, T, Stovner, L, Abdulkader, R, EI Szoeke, C, Tabarés-Seisdedos, R, Tanne, D, Theadom, A, Thrift, A, Tirschwell, D, Topor-Madry, R, Tran, B, Truelsen, T, Tuem, K, Ukwaja, K, Uthman, O, Varakin, Y, Vasankari, T, Venketasubramanian, N, Vlassov, V, Wadilo, F, Wakayo, T, Wallin, M, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, C, Woldu, M, Wolfe, C, Xavier, D, Xu, G, Yano, Y, Yimam, H, Yonemoto, N, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zunt, J, Murray, C, and Vos, T
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Cost of Illness ,Nutrition and Disease ,GBD ,Voeding en Ziekte ,Humans ,Life Science ,Quality-Adjusted Life Years ,Nervous System Diseases ,Global Health ,Article ,Global Burden of Disease ,VLAG - Abstract
Background Comparable data on the global and country-specific burden of neurological disorders and their trends are\ud crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors\ud (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians\ud specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to\ud neurological disorders in 2015 and its relationship with country development level.\ud \ud Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years\ud of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification\ud have been previously spread across multiple disease groupings. The more inclusive grouping of neurological\ud disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer’s disease and other dementias, Parkinson’s\ud disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse\ud headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed\ud results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and\ud fertility, to identify patterns associated with development and how countries fare against expected outcomes relative\ud to their level of development.\ud \ud Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval\ud (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4\ud [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tensiontype\ud headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication\ud overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer’s disease and other dementias (46·0\ud [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by\ud 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of\ud death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were\ud responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in\ud countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the\ud changes in DALY rates of neurological disorders with development were driven by changes in YLLs.\ud \ud Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden\ud of neurological disorders has increased substantially over the past 25 years because of expanding population numbers\ud and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders.\ud The number of patients who will need care by clinicians with expertise in neurological conditions will continue to\ud grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate\ud services.\ud \ud Funding Bill & Melinda Gates Foundation.
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- 2017
10. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: An analysis from the Global Burden of Disease Study 2016.
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Soljak M., Sykes B.L., Sylte D.O., Szoeke C.E.I., Tabares-Seisdedos R., Tadakamadla S.K., Tandon N., Tao T., Tarekegn Y.L., Tavakkoli M., Taveira N., Tegegne T.K., Shifa G.T., Terkawi A.S., Tessema G.A., Thakur J.S., Thankappan K.R., Tiruye T.Y., Tobe-Gai R., Topor-Madry R., Torre A., Tortajada M., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Updike R., Uthman O.A., Van Boven J.F.M., Van Donkelaar A., Varughese S., Vasankari T., Venketasubramanian N., Vidavalur R., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wadilo F., Wakayo T., Wallin M.T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Xavier D., Xu G., Yadgir S., Yakob B., Yan L.L., Yano Y., Yaseri M., Ye P., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zavala-Arciniega L., Zhang X., Zipkin B., Zodpey S., Lim S.S., Murray C.J.L., De Courten B., Thrift A.G., Fullman N., Barber R.M., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abera S.F., Aboyans V., Abu-Raddad L.J., Abu-Rmeileh N.M.E., Adedeji I.A., Adetokunboh O., Afshin A., Agrawal A., Agrawal S., Kiadaliri A.A., Ahmadieh H., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemi R.O., Akseer N., Al-Aly Z., Alam K., Alam N., Alasfoor D., Alene K.A., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Antonio C.A.T., Ansari H., Anwari P., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Assadi R., Atey T.M., Atre S.R., Avila-Burgos L., Arthur Avokpaho E.F.G., Awasthi A., Azzopardi P., Bacha U., Badawi A., Balakrishnan K., Bannick M.S., Barac A., Barker-Collo S.L., Barnighausen T., Barrero L.H., Basu S., Battle K.E., Baune B.T., Beardsley J., Bedi N., Beghi E., Bejot Y., Bell M.L., Bennett D.A., Bennett J.R., Bensenor I.M., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhatt S., Bhutta Z.A., Bikbov B., Bilal A.I., Birungi C., Biryukov S., Bizuayehu H.M., Blosser C.D., Boneya D.J., Bose D., Bou-Orm I.R., Brauer M., Breitborde N.J.K., Brugha T.S., Bulto L.N.B., Butt Z.A., Cahuana-Hurtado L., Cameron E., Campuzano J.C., Carabin H., Cardenas R., Carrero J.J., Carter A., Casey D.C., Castaneda-Orjuela C.A., Rivas J.C., Castro R.E., Catala-Lopez F., Cercy K., Chang H.-Y., Chang J.-C., Charlson F.J., Chew A., Chisumpa V.H., Chitheer A.A., Christensen H., Christopher D.J., Cirillo M., Cooper C., Criqui M.H., Cromwell E.A., Crump J.A., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davitoiu D.V., De Steur H., Degenhardt L., Deiparine S., Deribe K., DeVeber G.A., Ding E.L., Djalalinia S., Do H.P., Dokova K., Doku D.T., Dorsey E.R., Driscoll T.R., Dubey M., Duncan B.B., Ebel B.E., Ebrahimi H., El-Khatib Z.Z., Enayati A., Endries A.Y., Ermakov S.P., Erskine H.E., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Faraon E.J.A., Sofia E Sa Farinha C., Faro A., Farzadfar F., Fazeli M.S., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Fischer F., Fitzmaurice C., Flaxman A.D., Foigt N., Foreman K.J., Frank T., Franklin R.C., Friedman J., Frostad J.J., Furst T., Furtado J.M., Gakidou E., Garcia-Basteiro A.L., Gebrehiwot T.T., Geleijnse J.M., Geleto A., Gemechu B.L., Gething P.W., Gibney K.B., Gill P.S., Gillum R.F., Giref A.Z., Gishu M.D., Giussani G., Glenn S.D., Godwin W.W., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goryakin Y., Griswold M., Gugnani H.C., Gupta R., Gupta T., Gupta V., Hafezi-Nejad N., Bidgoli H.H., Hailu G.B., Hamadeh R.R., Hammami M., Hankey G.J., Harb H.L., Hareri H.A., Hassanvand M.S., Havmoeller R., Hawley C., Hay S.I., He J., Hendrie D., Henry N.J., Heredia-Pi I.B., Hoek H.W., Holmberg M., Horita N., Hosgood H.D., Hostiuc S., Hoy D.G., Hsairi M., Htet A.S., Huang H., Huang J.J., Huynh C., Iburg K.M., Ikeda C., Inoue M., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Jauregui A., Javanbakht M., Jeemon P., Jha V., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Karch A., Karema C.K., Kasaeian A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kelbore S.G., Kemmer L., Kengne A.P., Kesavachandran C.N., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khosravi A., Khubchandani J., Kieling C., Kim D., Kim J.Y., Kim Y.J., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kivimaki M., Kokubo Y., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krohn K.J., Defo B.K., Bicer B.K., Kulikoff X.R., Kumar G.A., Kutz M.J., Kyu H.H., Lal D.K., Lalloo R., Lansingh V.C., Larsson A., Lazarus J.V., Lee P.H., Leigh J., Leung J., Leung R., Levi M., Li Y., Liben M.L., Linn S., Liu P.Y., Liu S., Lodha R., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Lunevicius R., Mackay M.T., Maddison E.R., El Razek H.M.A., El Razek M.M.A., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Mantovani L.G., Manyazewal T., Mapoma C.C., Marks G.B., Martin R.V., Martinez-Raga J., Martins-Melo F.R., Martopullo I., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., Mehata S., Mehndiratta M.M., Meier T., Meles K.G., Memish Z.A., Mendoza W., Mengesha M.M., Mengistie M.A., Mensah G.A., Mensink G.B.M., Mereta S.T., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Minnig S., Mirarefin M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammed K.E., Mohammed S., Mohan M.B.V., Mokdad A.H., Mollenkopf S.K., Monasta L., Hernandez J.C.M., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Morrison S.D., Moses M.W., Mountjoy-Venning C., Mueller U.O., Muller K., Murthy G.V.S., Musa K.I., Naghavi M., Naheed A., Naidoo K.S., Nangia V., Natarajan G., Negoi I., Negoi R.I., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nomura M., Nong V.M., Norheim O.F., Noubiap J.J.N., Obermeyer C.M., Ogbo F.A., Oh I.-H., Oladimeji O., Olagunju A.T., Olagunju T.O., Olivares P.R., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Oren E., Ortiz A., Owolabi M.O., Mahesh P.A., Pana A., Panda B.K., Panda-Jonas S., Papachristou C., Park E.-K., Patton G.C., Paulson K., Pereira D.M., Perico D.N., Pesudovs K., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Piradov M.A., Pishgar F., Poulton R.G., Pourmalek F., Qorbani M., Radfar A., Rafay A., Rao P.C., Rahimi-Movaghar V., Rahman M., Ur Rahman M.H., Rahman M.A., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rawaf S., Reidy P., Reiner R.C., Reinig N., Reitsma M.B., Remuzzi G., Renzaho A.M.N., Resnikoff S., Rezaei S., Blancas M.J.R., Roba K.T., Rojas-Rueda D., Rokni M.B., Roshandel G., Roth G.A., Roy A., Rubagotti E., Sadat N., Safdarian M., Safi S., Safiri S., Sagar R., Salama J., Salomon J.A., Samy A.M., Sanabria J.R., Santomauro D., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Saylan M.I., Shirude S., Schmidt M.I., Schneider I.J.C., Schneider M.T., Schottker B., Schutte A.E., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shamsipour M., Shamsizadeh M., Islam S.M.S., Sharma J., Sharma R., She J., Shi P., Shibuya K., Shields C., Shiferaw M.S., Shigematsu M., Shin M.-J., Shiri R., Shirkoohi R., Shishani K., Shoman H., Shrime M.G., Silberberg D.H., Silva D.A.S., Silva J.P., Silveira D.G.A., Singh J.A., Singh V., Sinha D.N., Skiadaresi E., Slepak E.L., Sligar A., Smith A., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Soneji S., Sorensen R.J.D., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stein D.J., Steiner C., Steinke S., Stokes M.A., Strub B., Sufiyan M.B., Abdulkader R.S., Sunguya B.F., Sur P.J., Swaminathan S., Soljak M., Sykes B.L., Sylte D.O., Szoeke C.E.I., Tabares-Seisdedos R., Tadakamadla S.K., Tandon N., Tao T., Tarekegn Y.L., Tavakkoli M., Taveira N., Tegegne T.K., Shifa G.T., Terkawi A.S., Tessema G.A., Thakur J.S., Thankappan K.R., Tiruye T.Y., Tobe-Gai R., Topor-Madry R., Torre A., Tortajada M., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Updike R., Uthman O.A., Van Boven J.F.M., Van Donkelaar A., Varughese S., Vasankari T., Venketasubramanian N., Vidavalur R., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wadilo F., Wakayo T., Wallin M.T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Xavier D., Xu G., Yadgir S., Yakob B., Yan L.L., Yano Y., Yaseri M., Ye P., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zavala-Arciniega L., Zhang X., Zipkin B., Zodpey S., Lim S.S., Murray C.J.L., De Courten B., Thrift A.G., Fullman N., Barber R.M., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abera S.F., Aboyans V., Abu-Raddad L.J., Abu-Rmeileh N.M.E., Adedeji I.A., Adetokunboh O., Afshin A., Agrawal A., Agrawal S., Kiadaliri A.A., Ahmadieh H., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemi R.O., Akseer N., Al-Aly Z., Alam K., Alam N., Alasfoor D., Alene K.A., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Antonio C.A.T., Ansari H., Anwari P., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Assadi R., Atey T.M., Atre S.R., Avila-Burgos L., Arthur Avokpaho E.F.G., Awasthi A., Azzopardi P., Bacha U., Badawi A., Balakrishnan K., Bannick M.S., Barac A., Barker-Collo S.L., Barnighausen T., Barrero L.H., Basu S., Battle K.E., Baune B.T., Beardsley J., Bedi N., Beghi E., Bejot Y., Bell M.L., Bennett D.A., Bennett J.R., Bensenor I.M., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhatt S., Bhutta Z.A., Bikbov B., Bilal A.I., Birungi C., Biryukov S., Bizuayehu H.M., Blosser C.D., Boneya D.J., Bose D., Bou-Orm I.R., Brauer M., Breitborde N.J.K., Brugha T.S., Bulto L.N.B., Butt Z.A., Cahuana-Hurtado L., Cameron E., Campuzano J.C., Carabin H., Cardenas R., Carrero J.J., Carter A., Casey D.C., Castaneda-Orjuela C.A., Rivas J.C., Castro R.E., Catala-Lopez F., Cercy K., Chang H.-Y., Chang J.-C., Charlson F.J., Chew A., Chisumpa V.H., Chitheer A.A., Christensen H., Christopher D.J., Cirillo M., Cooper C., Criqui M.H., Cromwell E.A., Crump J.A., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davitoiu D.V., De Steur H., Degenhardt L., Deiparine S., Deribe K., DeVeber G.A., Ding E.L., Djalalinia S., Do H.P., Dokova K., Doku D.T., Dorsey E.R., Driscoll T.R., Dubey M., Duncan B.B., Ebel B.E., Ebrahimi H., El-Khatib Z.Z., Enayati A., Endries A.Y., Ermakov S.P., Erskine H.E., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Faraon E.J.A., Sofia E Sa Farinha C., Faro A., Farzadfar F., Fazeli M.S., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Fischer F., Fitzmaurice C., Flaxman A.D., Foigt N., Foreman K.J., Frank T., Franklin R.C., Friedman J., Frostad J.J., Furst T., Furtado J.M., Gakidou E., Garcia-Basteiro A.L., Gebrehiwot T.T., Geleijnse J.M., Geleto A., Gemechu B.L., Gething P.W., Gibney K.B., Gill P.S., Gillum R.F., Giref A.Z., Gishu M.D., Giussani G., Glenn S.D., Godwin W.W., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goryakin Y., Griswold M., Gugnani H.C., Gupta R., Gupta T., Gupta V., Hafezi-Nejad N., Bidgoli H.H., Hailu G.B., Hamadeh R.R., Hammami M., Hankey G.J., Harb H.L., Hareri H.A., Hassanvand M.S., Havmoeller R., Hawley C., Hay S.I., He J., Hendrie D., Henry N.J., Heredia-Pi I.B., Hoek H.W., Holmberg M., Horita N., Hosgood H.D., Hostiuc S., Hoy D.G., Hsairi M., Htet A.S., Huang H., Huang J.J., Huynh C., Iburg K.M., Ikeda C., Inoue M., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Jauregui A., Javanbakht M., Jeemon P., Jha V., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Karch A., Karema C.K., Kasaeian A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kelbore S.G., Kemmer L., Kengne A.P., Kesavachandran C.N., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khosravi A., Khubchandani J., Kieling C., Kim D., Kim J.Y., Kim Y.J., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kivimaki M., Kokubo Y., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krohn K.J., Defo B.K., Bicer B.K., Kulikoff X.R., Kumar G.A., Kutz M.J., Kyu H.H., Lal D.K., Lalloo R., Lansingh V.C., Larsson A., Lazarus J.V., Lee P.H., Leigh J., Leung J., Leung R., Levi M., Li Y., Liben M.L., Linn S., Liu P.Y., Liu S., Lodha R., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Lunevicius R., Mackay M.T., Maddison E.R., El Razek H.M.A., El Razek M.M.A., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Mantovani L.G., Manyazewal T., Mapoma C.C., Marks G.B., Martin R.V., Martinez-Raga J., Martins-Melo F.R., Martopullo I., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., Mehata S., Mehndiratta M.M., Meier T., Meles K.G., Memish Z.A., Mendoza W., Mengesha M.M., Mengistie M.A., Mensah G.A., Mensink G.B.M., Mereta S.T., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Minnig S., Mirarefin M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammed K.E., Mohammed S., Mohan M.B.V., Mokdad A.H., Mollenkopf S.K., Monasta L., Hernandez J.C.M., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Morrison S.D., Moses M.W., Mountjoy-Venning C., Mueller U.O., Muller K., Murthy G.V.S., Musa K.I., Naghavi M., Naheed A., Naidoo K.S., Nangia V., Natarajan G., Negoi I., Negoi R.I., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nomura M., Nong V.M., Norheim O.F., Noubiap J.J.N., Obermeyer C.M., Ogbo F.A., Oh I.-H., Oladimeji O., Olagunju A.T., Olagunju T.O., Olivares P.R., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Oren E., Ortiz A., Owolabi M.O., Mahesh P.A., Pana A., Panda B.K., Panda-Jonas S., Papachristou C., Park E.-K., Patton G.C., Paulson K., Pereira D.M., Perico D.N., Pesudovs K., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Piradov M.A., Pishgar F., Poulton R.G., Pourmalek F., Qorbani M., Radfar A., Rafay A., Rao P.C., Rahimi-Movaghar V., Rahman M., Ur Rahman M.H., Rahman M.A., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rawaf S., Reidy P., Reiner R.C., Reinig N., Reitsma M.B., Remuzzi G., Renzaho A.M.N., Resnikoff S., Rezaei S., Blancas M.J.R., Roba K.T., Rojas-Rueda D., Rokni M.B., Roshandel G., Roth G.A., Roy A., Rubagotti E., Sadat N., Safdarian M., Safi S., Safiri S., Sagar R., Salama J., Salomon J.A., Samy A.M., Sanabria J.R., Santomauro D., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Saylan M.I., Shirude S., Schmidt M.I., Schneider I.J.C., Schneider M.T., Schottker B., Schutte A.E., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shamsipour M., Shamsizadeh M., Islam S.M.S., Sharma J., Sharma R., She J., Shi P., Shibuya K., Shields C., Shiferaw M.S., Shigematsu M., Shin M.-J., Shiri R., Shirkoohi R., Shishani K., Shoman H., Shrime M.G., Silberberg D.H., Silva D.A.S., Silva J.P., Silveira D.G.A., Singh J.A., Singh V., Sinha D.N., Skiadaresi E., Slepak E.L., Sligar A., Smith A., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Soneji S., Sorensen R.J.D., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stein D.J., Steiner C., Steinke S., Stokes M.A., Strub B., Sufiyan M.B., Abdulkader R.S., Sunguya B.F., Sur P.J., and Swaminathan S.
- Abstract
Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030. Method(s): We used standardised GBD 2016 methods to measure 37 health-related indicators from 1990 to 2016, an increase of four indicators since GBD 2015. We substantially revised the universal health coverage (UHC) measure, which focuses on coverage of essential health services, to also represent personal health-care access and quality for several non-communicable diseases. We transformed each indicator on a scale of 0-100, with 0 as the 25th percentile estimated between 1990 and 2030, and 100 as the 975th percentile during that time. An index representing all 37 health-related SDG indicators was constructed by taking the geometric mean of scaled indicators by target. On the basis of past trends, we produced projections of indicator values, using a weighted average of the indicator and country-specific annualised rates of change from 1990 to 2016 with weights for each annual rate of change based on out-of-sample validity. 24 of the currently measured health-related SDG indicators have defined SDG targets, against which we assessed attainment. Findings Globally, the median health-related SDG index was 567 (IQR 319-668) in 2016 and country-level performance markedly varied, with Singapore (868, 95% uncertainty interval 846-889), Iceland (860, 841-876), and Sweden (856, 818-878) having the highest levels in 2016 and Afghanistan (109, 96-119), the Central African Republic (110, 88-138), and Somalia (113, 95-131) recording the lowest. Betwee
- Published
- 2018
11. The global burden of disease study 2013: What does it mean for the NTDs?
- Author
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Herricks, J.R. (Jennifer R.), Hotez, P.J. (Peter), Wanga, V. (Valentine), Coffeng, L.E. (Luc), Haagsma, J.A. (Juanita), Basáñez, M-G. (María-Gloria), Buckle, G. (Geoffrey), Budke, C.M. (Christine), Carabin, H. (Hélène), Fèvre, E.M. (Eric), Fürst, T. (Thomas), Halasa, Y.A. (Yara A.), King, C.H. (Charles H.), Murdoch, M.E. (Michele E.), Ramaiah, K.D. (Kapa), Shepard, D.S. (Donald S.), Stolk, W.A. (Wilma), Undurraga, E.A. (Eduardo A.), Stanaway, J.D. (Jeffrey D.), Naghavi, M. (Morteza), Murray, C.J.L. (Christopher), Herricks, J.R. (Jennifer R.), Hotez, P.J. (Peter), Wanga, V. (Valentine), Coffeng, L.E. (Luc), Haagsma, J.A. (Juanita), Basáñez, M-G. (María-Gloria), Buckle, G. (Geoffrey), Budke, C.M. (Christine), Carabin, H. (Hélène), Fèvre, E.M. (Eric), Fürst, T. (Thomas), Halasa, Y.A. (Yara A.), King, C.H. (Charles H.), Murdoch, M.E. (Michele E.), Ramaiah, K.D. (Kapa), Shepard, D.S. (Donald S.), Stolk, W.A. (Wilma), Undurraga, E.A. (Eduardo A.), Stanaway, J.D. (Jeffrey D.), Naghavi, M. (Morteza), and Murray, C.J.L. (Christopher)
- Published
- 2017
- Full Text
- View/download PDF
12. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016.
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Kaul A., Bhutta Z.A., Hailu G.B., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Harun K.M., Harvey J., Hassanvand M.S., Havmoeller R., Hay R.J., Hedayati M.T., Hendrie D., Henry N.J., Heredia-Pi I.B., Heydarpour P., Hoek H.W., Hofman H.J., Horino M., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Htet A.S., Hu G., Huang J.J., Huynh C., Iburg K.M., Igumbor E.U., Ikeda C., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., James P., Jassal S.K., Javanbakht M., Jayaraman S.P., Jeemon P., Jensen P.N., Jha V., Jiang G., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Kar C., Karam N.E., Karch A., Karema C.K., Karimi S.M., Karimkhani C., Kasaeian A., Kassa G.M., Kassebaum N.J., Kassaw N.A., Kastor A., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kemmer L., Kengne A.P., Keren A., Kesavachandran C.N., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khoja A.T., Khosravi A., Khubchandani J., Kieling C., Kim Y.J., Kim D., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kissoon N., Kivimaki M., Knudsen A.K., Kokubo Y., Kolte D., Kopec J.A., Kosen S., Kotsakis G.A., Koul P.A., Koyanagi A., Kravchenko M., Krohn K.J., Defo B.K., Bicer B.K., Kumar G.A., Kumar P., Kyu H.H., Lager A.C.J., Lal D.K., Lalloo R., Lallukka T., Lambert N., Lan Q., Lansingh V.C., Larsson A., Leasher J.L., Lee P.H., Leigh J., Leshargie C.T., Leung J., Leung R., Levi M., Li Y., Liang X., Liben M.L., Lim S.S., Linn S., Liu A., Liu P.Y., Liu S., Liu Y., Lodha R., Logroscino G., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Lunevicius R., Lyons R.A., Macarayan E.R.K., Maddison E.R., Magdy Abd El Razek H., Magdy Abd El Razek M., Magis-Rodriguez C., Mahdavi M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Manhertz T., Mantovani L.G., Mapoma C.C., March L.M., Marczak L.B., Martinez-Raga J., Martins P.H.V., Martins-Melo F.R., Martopullo I., Marz W., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., Mehata S., Meier T., Meles K.G., Memiah P., Memish Z.A., Mendoza W., Mengesha M.M., Mengistie M.A., Mengistu D.T., Mensah G.A., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Minnig S., Mirarefn M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammadi A., Mohammed S., Mohammed K.E., Mohammed M.S.K., Mohan M.B.V., Mokdad A.H., Mollenkopf S.K., Monasta L., Montanez Hernandez J.C., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Mori R., Morrison S.D., Moses M., Mountjoy-Venning C., Mruts K.B., Mueller U.O., Muller K., Mudoch M.E., Murthy S., Murthy G.V.S., Musa K.I., Nachega J.B., Nagel G., Naghavi M., Naheed A., Naidoo K.S., Nangia V., Nasher J.T., Natarajan G., Negasa D.E., Negoi I., Negoi R.I., Newton C.R., Ngunjiri J.W., Nguyen C.T., Nguyen Q.L., Nguyen G., Nguyen T.H., Nguyen M., Nichols E., Ningrum D.N.A., Nong V.M., Norheim O.F., Norrving B., Noubiap J.J.N., Nyandwi A., Obermeyer C.M., O'Donnell M.J., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olagunju T.O., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osborne R.H., Osgood-Zimmerman A., Osman M., Ota E., Owolabi M.O., Pa M., Pacella R.E., Panda B.K., Pandian J.D., Papachristou C., Park E.-K., Parry C.D., Parsaeian M., Patil S.T., Patten S.B., Patton G.C., Paudel D., Paulson K., Pearce N., Pereira D.M., Perez K.M., Perico N., Pesudovs K., Peterson C.B., Petri W.A., Petzold M., Phillips M.R., Phipps G., Pigott D.M., Pillay J.D., Pinho C., Piradov M.A., Plass D., Pletcher M.A., Popova S., Poulton R.G., Pourmalek F., Prabhakaran D., Prasad N., Purcell C., Purwar M., Qorbani M., Rabiee R.H.S., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.A., Rahman M.H.U., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rangaswamy T., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Ray S.E., Reiner R.C., Reinig N., Reitsma M., Remuzzi G., Renzaho A.M.N., Resnikof S., Rezaei S., Ribeiro A.L., Roba H.S., Robinson S.R., Rojas-Rueda D., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy A., Rubagotti E., Ruhago G.M., Saadat S., Safdarian M., Safri S., Sagar R., Sahathevan R., Sahraian M.A., Salama J., Saleh M.M., Salomon J.A., Salvi S.S., Samy A.M., Sanabria J.R., Sanchez-Nino M.D., Santomauro D., Santos J.V., Santos I.S., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Schelonka K., Schmidt M.I., Schneider I.J.C., Schottker B., Schutte A.E., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Shaheen A., Shaikh M.A., Shamsipour M., Shariful Islam S.M., Sharma R., Sharma J., She J., Shi P., Shibuya K., Shields C., Shiferaw M.S., Shigematsu M., Shiri R., Shirkoohi R., Shirude S., Shishani K., Shoman H., Siabani S., Sibai A.M., Sigfusdottir I.D., Silberberg D.H., Silva J.P., Silva D.A.S., Silveira D.G.A., Singh J.A., Singh V., Singh O.P., Singh N.P., Sinha D.N., Skiadaresi E., Skirbekk V., Slepak E.L., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Soljak M., Sorensen R.J.D., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Steiner C., Steinke S., Stokes M.A., Stovner L.J., Strub B., Subart M., Sufyan M.B., Abdulkader R.S., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Sylte D., Szoeke C.E.I., Tabares-Seisdedos R., Tadakamadla S.K., Tafere G.R., Takala J.S., Tandon N., Tanne D., Tarekegn Y.L., Tavakkoli M., Taveira N., Taylor H.R., Tegegne T.K., Tehrani-Banihashemi A., Tekelab T., Temam Shifa G., Terkawi A.S., Tesfaye D.J., Tesssema B., Thakur J.S., Thamsuwan O., Theadom A.M., Theis A.M., Thomas K.E., Thomas N., Thompson R., Tobe-Gai R., Tobollik M., Tonelli M., Topor-Madry R., Tortajada M., Touvier M., Traebert J., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuzcu E.M., Tymeson H., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varughese S., Vasankari T., Veerman L.J., Venkatesh S., Venketasubramanian N., Vidavalur R., Vijayakumar L., Violante F.S., Vishnu A., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wadilo F., Wakayo T., Wallin M.T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Williams H.C., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Woolf A.D., Workicho A., Xavier D., Xu G., Yadgir S., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Ye P., Yihdego M.G., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Yu C., Zaidi Z., Zaki M.E.S., Zegeye E.A., Zenebe Z.M., Zhang X., Zheng Y., Zhou M., Zipkin B., Zodpey S., Zoeckler L., Zuhlke L.J., Murray C.J.L., Adedji I.A., Murdoch M.E., Bryane C.E.G., De Courten B., Thrift A.G., Biadgilign S., Hay S.I., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abebo T.A., Abera S.F., Aboyans V., Abu-Raddad L.J., Ackerman I.N., Adedeji I.A., Adetokunboh O., Afshin A., Aggarwal R., Agrawal S., Agrawal A., Kiadaliri A.A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemiju T.F., Akseer N., Al Lami F.H., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alasfoor D., Alene K.A., Ali R., Alizadeh-Navaei R., Alkaabi J.M., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Maskari F., Almazroa M.A., Al-Raddadi R., Alsharif U., Alsowaidi S., Althouse B.M., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amoako Y.A., Ansha M.G., Antonio C.A.T., Anwari P., Arnlov J., Arora M., Artaman A., Aryal K.K., Asgedom S.W., Atey T.M., Atnafu N.T., Avila-Burgos L., Arthur Avokpaho E.F.G., Awasthi A., Awasthi S., Quintanilla B.P.A., Azarpazhooh M.R., Azzopardi P., Babalola T.K., Bacha U., Badawi A., Balakrishnan K., Bannick M.S., Barac A., Barker-Collo S.L., Barnighausen T., Barquera S., Barrero L.H., Basu S., Battista R., Battle K.E., Baune B.T., Bazargan-Hejazi S., Beardsley J., Bedi N., Bejot Y., Bekele B.B., Bell M.L., Bennett D.A., Bennett J.R., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhansali A., Bhatt S., Bienhof K., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Blyth F.M., Boneya D.J., Bose D., Bou-Orm I.R., Bourne R.R.A., Brainin M., Brayne C.E.G., Brazinova A., Breitborde N.J.K., Briant P.S., Britton G., Brugha T.S., Buchbinder R., Bulto L.N.B., Bumgarner B., Butt Z.A., Cahuana-Hurtado L., Cameron E., Campos-Nonato I.R., Carabin H., Cardenas R., Carpenter D.O., Carrero J.J., Carter A., Carvalho F., Casey D., Castaneda-Orjuela C.A., Rivas J.C., Castle C.D., Catala-Lopez F., Chang J.-C., Charlson F.J., Chaturvedi P., Chen H., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Chowdhury R., Christopher D.J., Ciobanu L.G., 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A.L., Gebre T., Gebregergs G.B., Gebrehiwot T.T., Geleijnse J.M., Geleto A., Gemechu B.L., Gesesew H.A., Gething P.W., Ghajar A., Gibney K.B., Gillum R.F., Ginawi I.A.M., Gishu M.D., Giussani G., Godwin W.W., Goel K., Goenka S., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Gosselin R.A., Gotay C.C., Goto A., Goulart A.C., Graetz N., Gugnani H.C., Gupta P.C., Gupta T., Gupta V., Gupta R., Gutierrez R.A., Hachinski V., Hafezi-Nejad N., Hailu A.D., Kaul A., Bhutta Z.A., Hailu G.B., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Harun K.M., Harvey J., Hassanvand M.S., Havmoeller R., Hay R.J., Hedayati M.T., Hendrie D., Henry N.J., Heredia-Pi I.B., Heydarpour P., Hoek H.W., Hofman H.J., Horino M., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Htet A.S., Hu G., Huang J.J., Huynh C., Iburg K.M., Igumbor E.U., Ikeda C., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., James P., Jassal S.K., Javanbakht M., Jayaraman S.P., Jeemon P., Jensen P.N., Jha V., Jiang G., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Kar C., Karam N.E., Karch A., Karema C.K., Karimi S.M., Karimkhani C., Kasaeian A., Kassa G.M., Kassebaum N.J., Kassaw N.A., Kastor A., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kemmer L., Kengne A.P., Keren A., Kesavachandran C.N., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khoja A.T., Khosravi A., Khubchandani J., Kieling C., Kim Y.J., Kim D., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kissoon N., Kivimaki M., Knudsen A.K., Kokubo Y., Kolte D., Kopec J.A., Kosen S., Kotsakis G.A., Koul P.A., Koyanagi A., Kravchenko M., Krohn K.J., Defo B.K., Bicer B.K., Kumar G.A., Kumar P., Kyu H.H., Lager A.C.J., Lal D.K., Lalloo R., Lallukka T., Lambert N., Lan Q., Lansingh V.C., Larsson A., Leasher J.L., Lee P.H., Leigh J., Leshargie C.T., Leung J., Leung R., Levi M., Li Y., Liang X., Liben M.L., Lim S.S., Linn S., Liu A., Liu P.Y., Liu S., Liu Y., Lodha R., Logroscino G., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Lunevicius R., Lyons R.A., Macarayan E.R.K., Maddison E.R., Magdy Abd El Razek H., Magdy Abd El Razek M., Magis-Rodriguez C., Mahdavi M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Manhertz T., Mantovani L.G., Mapoma C.C., March L.M., Marczak L.B., Martinez-Raga J., Martins P.H.V., Martins-Melo F.R., Martopullo I., Marz W., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., Mehata S., Meier T., Meles K.G., Memiah P., Memish Z.A., Mendoza W., Mengesha M.M., Mengistie M.A., Mengistu D.T., Mensah G.A., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Minnig S., Mirarefn M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammadi A., Mohammed S., Mohammed K.E., Mohammed M.S.K., Mohan M.B.V., Mokdad A.H., Mollenkopf S.K., Monasta L., Montanez Hernandez J.C., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Mori R., Morrison S.D., Moses M., Mountjoy-Venning C., Mruts K.B., Mueller U.O., Muller K., Mudoch M.E., Murthy S., Murthy G.V.S., Musa K.I., Nachega J.B., Nagel G., Naghavi M., Naheed A., Naidoo K.S., Nangia V., Nasher J.T., Natarajan G., Negasa D.E., Negoi I., Negoi R.I., Newton C.R., Ngunjiri J.W., Nguyen C.T., Nguyen Q.L., Nguyen G., Nguyen T.H., Nguyen M., Nichols E., Ningrum D.N.A., Nong V.M., Norheim O.F., Norrving B., Noubiap J.J.N., Nyandwi A., Obermeyer C.M., O'Donnell M.J., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olagunju T.O., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osborne R.H., Osgood-Zimmerman A., Osman M., Ota E., Owolabi M.O., Pa M., Pacella R.E., Panda B.K., Pandian J.D., Papachristou C., Park E.-K., Parry C.D., Parsaeian M., Patil S.T., Patten S.B., Patton G.C., Paudel D., Paulson K., Pearce N., Pereira D.M., Perez K.M., Perico N., Pesudovs K., Peterson C.B., Petri W.A., Petzold M., Phillips M.R., Phipps G., Pigott D.M., Pillay J.D., Pinho C., Piradov M.A., Plass D., Pletcher M.A., Popova S., Poulton R.G., Pourmalek F., Prabhakaran D., Prasad N., Purcell C., Purwar M., Qorbani M., Rabiee R.H.S., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.A., Rahman M.H.U., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rangaswamy T., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Ray S.E., Reiner R.C., Reinig N., Reitsma M., Remuzzi G., Renzaho A.M.N., Resnikof S., Rezaei S., Ribeiro A.L., Roba H.S., Robinson S.R., Rojas-Rueda D., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy A., Rubagotti E., Ruhago G.M., Saadat S., Safdarian M., Safri S., Sagar R., Sahathevan R., Sahraian M.A., Salama J., Saleh M.M., Salomon J.A., Salvi S.S., Samy A.M., Sanabria J.R., Sanchez-Nino M.D., Santomauro D., Santos J.V., Santos I.S., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Schelonka K., Schmidt M.I., Schneider I.J.C., Schottker B., Schutte A.E., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Shaheen A., Shaikh M.A., Shamsipour M., Shariful Islam S.M., Sharma R., Sharma J., She J., Shi P., Shibuya K., Shields C., Shiferaw M.S., Shigematsu M., Shiri R., Shirkoohi R., Shirude S., Shishani K., Shoman H., Siabani S., Sibai A.M., Sigfusdottir I.D., Silberberg D.H., Silva J.P., Silva D.A.S., Silveira D.G.A., Singh J.A., Singh V., Singh O.P., Singh N.P., Sinha D.N., Skiadaresi E., Skirbekk V., Slepak E.L., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Soljak M., Sorensen R.J.D., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Steiner C., Steinke S., Stokes M.A., Stovner L.J., Strub B., Subart M., Sufyan M.B., Abdulkader R.S., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Sylte D., Szoeke C.E.I., Tabares-Seisdedos R., Tadakamadla S.K., Tafere G.R., Takala J.S., Tandon N., Tanne D., Tarekegn Y.L., Tavakkoli M., Taveira N., Taylor H.R., Tegegne T.K., Tehrani-Banihashemi A., Tekelab T., Temam Shifa G., Terkawi A.S., Tesfaye D.J., Tesssema B., Thakur J.S., Thamsuwan O., Theadom A.M., Theis A.M., Thomas K.E., Thomas N., Thompson R., Tobe-Gai R., Tobollik M., Tonelli M., Topor-Madry R., Tortajada M., Touvier M., Traebert J., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuzcu E.M., Tymeson H., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varughese S., Vasankari T., Veerman L.J., Venkatesh S., Venketasubramanian N., Vidavalur R., Vijayakumar L., Violante F.S., Vishnu A., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wadilo F., Wakayo T., Wallin M.T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Williams H.C., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Woolf A.D., Workicho A., Xavier D., Xu G., Yadgir S., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Ye P., Yihdego M.G., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Yu C., Zaidi Z., Zaki M.E.S., Zegeye E.A., Zenebe Z.M., Zhang X., Zheng Y., Zhou M., Zipkin B., Zodpey S., Zoeckler L., Zuhlke L.J., Murray C.J.L., Adedji I.A., Murdoch M.E., Bryane C.E.G., De Courten B., Thrift A.G., Biadgilign S., Hay S.I., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abebo T.A., Abera S.F., Aboyans V., Abu-Raddad L.J., Ackerman I.N., Adedeji I.A., Adetokunboh O., Afshin A., Aggarwal R., Agrawal S., Agrawal A., Kiadaliri A.A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemiju T.F., Akseer N., Al Lami F.H., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alasfoor D., Alene K.A., Ali R., Alizadeh-Navaei R., Alkaabi J.M., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Maskari F., Almazroa M.A., Al-Raddadi R., Alsharif U., Alsowaidi S., Althouse B.M., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amoako Y.A., Ansha M.G., Antonio C.A.T., Anwari P., Arnlov J., Arora M., Artaman A., Aryal K.K., Asgedom S.W., Atey T.M., Atnafu N.T., Avila-Burgos L., Arthur Avokpaho E.F.G., Awasthi A., Awasthi S., Quintanilla B.P.A., Azarpazhooh M.R., Azzopardi P., Babalola T.K., Bacha U., Badawi A., Balakrishnan K., Bannick M.S., Barac A., Barker-Collo S.L., Barnighausen T., Barquera S., Barrero L.H., Basu S., Battista R., Battle K.E., Baune B.T., Bazargan-Hejazi S., Beardsley J., Bedi N., Bejot Y., Bekele B.B., Bell M.L., Bennett D.A., Bennett J.R., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhansali A., Bhatt S., Bienhof K., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Blyth F.M., Boneya D.J., Bose D., Bou-Orm I.R., Bourne R.R.A., Brainin M., Brayne C.E.G., Brazinova A., Breitborde N.J.K., Briant P.S., Britton G., Brugha T.S., Buchbinder R., Bulto L.N.B., Bumgarner B., Butt Z.A., Cahuana-Hurtado L., Cameron E., Campos-Nonato I.R., Carabin H., Cardenas R., Carpenter D.O., Carrero J.J., Carter A., Carvalho F., Casey D., Castaneda-Orjuela C.A., Rivas J.C., Castle C.D., Catala-Lopez F., Chang J.-C., Charlson F.J., Chaturvedi P., Chen H., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Chowdhury R., Christopher D.J., Ciobanu L.G., Cirillo M., Colombara D., Cooper L.T., Cooper C., Cortesi P.A., Cortinovis M., Criqui M.H., Cromwell E.A., Cross M., Crump J.A., Dadi A.F., Dalal K., Damasceno A., Dandona L., Dandona R., Das Neves J., Davitoiu D.V., Davletov K., De Leo D., De Steur H., Degenhardt L., Deiparine S., Dellavalle R.P., Deribe K., Deribew A., Das Jarlais D.C., Dey S., Dharmaratne S.D., Dhillon P.K., Dicker D., Djalalinia S., Do H.P., Dokova K., Doku D.T., Dorsey E.R., Dos Santos K.P.B., Driscoll T.R., Dubey M., Duncan B.B., Ebel B.E., Echko M., El-Khatib Z.Z., Enayati A., Endries A.Y., Ermakov S.P., Erskine H.E., Eshetie S., Eshrati B., Esteghamati A., Estep K., Fanuel F.B.B., Farag T., Farinha C.S.E.S., Faro A., Farzadfar F., Fazeli M.S., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Fischer F., Fitzmaurice C., Flaxman A.D., Foigt N., Foreman K.J., Franklin R.C., Frostad J.J., Fullman N., Furst T., Furtado J.M., Futran N.D., Gakidou E., Garcia-Basteiro A.L., Gebre T., Gebregergs G.B., Gebrehiwot T.T., Geleijnse J.M., Geleto A., Gemechu B.L., Gesesew H.A., Gething P.W., Ghajar A., Gibney K.B., Gillum R.F., Ginawi I.A.M., Gishu M.D., Giussani G., Godwin W.W., Goel K., Goenka S., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Gosselin R.A., Gotay C.C., Goto A., Goulart A.C., Graetz N., Gugnani H.C., Gupta P.C., Gupta T., Gupta V., Gupta R., Gutierrez R.A., Hachinski V., Hafezi-Nejad N., and Hailu A.D.
- Abstract
Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Method(s): We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Finding(s): The highest globally observed HALE at birth for both women and men was in Singapore, at 75.2 years (95% uncertainty interval 71.9-78.6) for females and 72.0 years (68.8-75.1) for males. The lowest for females was in the Central African Republic (45.6 years [42.0-49.5]) and for males was in Lesotho (41.5 years [39.0-44.0]). From 1990 to 2016, global HALE increased by an average of 6.24 years (5.97-6.48) for both sexes combined. Global HALE increased by 6.04 years (5.74-6.27) for males and 6.49 years (6.08-6.77) for females, whereas HALE at age 65 years increased by 1.78 years (1.61-1.93) for m
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- 2017
13. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
- Author
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Stanaway J.D., Li Y., Liang X., Liben M.L., Lo W.D., Logroscino G., Loy C.T., Mackay M.T., Meretoja A., Szoeke C.E.I., Abd El Razek H.M., Mantovani L.G., Massano J., Mazidi M., McAlinden C., Mehata S., Mehndiratta M.M., Memish Z.A., Mendoza W., Mensah G.A., Wijeratne T., Miller T.R., Mohamed Ibrahim N., Mohammadi A., Moradi-Lakeh M., Velasquez I.M., Musa K.I., Ngunjiri J.W., Ningrum D.N.A., Norrving B., Stein D.J., Noubiap J.J.N., Ogbo F.A., Renzaho A.M.N., Owolabi M.O., Pandian J.D., Parmar P.G., Pereira D.M., Petzold M., Phillips M.R., Poulton R.G., Pourmalek F., Qorbani M., Rafay A., Rai R.K., Rajsic S., Ranta A., Rezai M.S., Rubagotti E., Sachdev P., Safiri S., Sahathevan R., Samy A.M., Santalucia P., Sartorius B., Satpathy M., Sawhney M., Saylan M.I., Shaikh M.A., Shamsizadeh M., Sheth K.N., Shigematsu M., Silva D.A.S., Sobngwi E., Sposato L.A., Stovner L.J., Abdulkader R.S., Tanne D., Topor-Madry R., Truelsen T., Ukwaja K.N., Uthman O.A., Vasankari T., Venketasubramanian N., Vlassov V.V., Wadilo F., Wallin M.T., Westerman R., Wiysonge C.S., Wolfe C.D., Xavier D., Xu G., Yano Y., Yimam H.H., Yonemoto N., Yu C., Zaidi Z., Zaki M.E., Thrift A.G., Feigin V.L., Krishnamurthi R.V., Theadom A.M., Abajobir A.A., Mishra S.R., Ahmed M.B., Abate K.H., Mengistie M.A., Wakayo T., Abd-Allah F., Abdulle A.M., Abera S.F., Mohammed K.E., Abyu G.Y., Asgedom S.W., Atey T.M., Betsu B.D., Mezgebe H.B., Tuem K.B., Woldu M.A., Aichour A.N., Aichour I., Aichour M.T., Akinyemi R.O., Alabed S., Al-Raddadi R., Alvis-Guzman N., Amare A.T., Ansari H., Anwari P., Arnlov J., Fereshtehnejad S., Weiderpass E., Havmoeller R., Asayesh H., Avila-Burgos L., Avokpaho E.F.G.A., Afrique L.E.R.A.S., Azarpazhooh M.R., Barac A., Barboza M., Barker-Collo S.L., Barnighausen T., Farvid M.S., Mohammed S., Bedi N., Beghi E., Giussani G., Bennett D.A., Hay S.I., Goulart A.C., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Jeemon P., Bhaumik S., Dandona L., Dandona R., Kumar G.A., Birlik S.M., Biryukov S., Casey D., Foreman K.J., Goldberg E.M., Khalil I.A., Kyu H.H., Manhertz T., Mokdad A.H., Naghavi M., Nguyen G., Nichols E., Smith M., Murray C.J.L., Roth G.A., Vos T., Ellenbogen R.G., Jakovljevic M., Tirschwell D.L., Zunt J.R., Boneya D.J., Hambisa M., Bulto L.N.B., Carabin H., Castaneda-Orjuela C.A., Catala-Lopez F., Tabares-Seisdedos R., Chen H., Chitheer A.A., Chowdhury R., Christensen H., Deveber G.A., Dharmaratne S.D., Do H.P., Nguyen C.T., Nguyen Q.L., Nguyen T.H., Nong V.M., Dokova K., Dorsey E.R., Eskandarieh S., Fischer F., Majeed A., Steiner T.J., Rawaf S., Shakir R., Shoman H., Geleijnse J.M., Gillum R.F., Gona P.N., Gugnani H.C., Gupta R., Hachinski V., Hamadeh R.R., Hankey G.J., Hareri H.A., Heydarpour P., Sahraian M.A., Kasaeian A., Malekzadeh R., Roshandel G., Sepanlou S.G., Hotez P.J., Javanbakht M., Jonas J.B., Kalkonde Y., Kandel A., Karch A., Kastor A., Rahman M., Keiyoro P.N., Khader Y.S., Khan E.A., Khang Y., Khoja A.T.A., Tran B.X., Khubchandani J., Kim D., Kim Y.J., Kivimaki M., Kokubo Y., Kosen S., Kravchenko M., Piradov M.A., Varakin Y.Y., Defo B.K., Kulkarni C., Kumar R., Larsson A., Lavados P.M., Stanaway J.D., Li Y., Liang X., Liben M.L., Lo W.D., Logroscino G., Loy C.T., Mackay M.T., Meretoja A., Szoeke C.E.I., Abd El Razek H.M., Mantovani L.G., Massano J., Mazidi M., McAlinden C., Mehata S., Mehndiratta M.M., Memish Z.A., Mendoza W., Mensah G.A., Wijeratne T., Miller T.R., Mohamed Ibrahim N., Mohammadi A., Moradi-Lakeh M., Velasquez I.M., Musa K.I., Ngunjiri J.W., Ningrum D.N.A., Norrving B., Stein D.J., Noubiap J.J.N., Ogbo F.A., Renzaho A.M.N., Owolabi M.O., Pandian J.D., Parmar P.G., Pereira D.M., Petzold M., Phillips M.R., Poulton R.G., Pourmalek F., Qorbani M., Rafay A., Rai R.K., Rajsic S., Ranta A., Rezai M.S., Rubagotti E., Sachdev P., Safiri S., Sahathevan R., Samy A.M., Santalucia P., Sartorius B., Satpathy M., Sawhney M., Saylan M.I., Shaikh M.A., Shamsizadeh M., Sheth K.N., Shigematsu M., Silva D.A.S., Sobngwi E., Sposato L.A., Stovner L.J., Abdulkader R.S., Tanne D., Topor-Madry R., Truelsen T., Ukwaja K.N., Uthman O.A., Vasankari T., Venketasubramanian N., Vlassov V.V., Wadilo F., Wallin M.T., Westerman R., Wiysonge C.S., Wolfe C.D., Xavier D., Xu G., Yano Y., Yimam H.H., Yonemoto N., Yu C., Zaidi Z., Zaki M.E., Thrift A.G., Feigin V.L., Krishnamurthi R.V., Theadom A.M., Abajobir A.A., Mishra S.R., Ahmed M.B., Abate K.H., Mengistie M.A., Wakayo T., Abd-Allah F., Abdulle A.M., Abera S.F., Mohammed K.E., Abyu G.Y., Asgedom S.W., Atey T.M., Betsu B.D., Mezgebe H.B., Tuem K.B., Woldu M.A., Aichour A.N., Aichour I., Aichour M.T., Akinyemi R.O., Alabed S., Al-Raddadi R., Alvis-Guzman N., Amare A.T., Ansari H., Anwari P., Arnlov J., Fereshtehnejad S., Weiderpass E., Havmoeller R., Asayesh H., Avila-Burgos L., Avokpaho E.F.G.A., Afrique L.E.R.A.S., Azarpazhooh M.R., Barac A., Barboza M., Barker-Collo S.L., Barnighausen T., Farvid M.S., Mohammed S., Bedi N., Beghi E., Giussani G., Bennett D.A., Hay S.I., Goulart A.C., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Jeemon P., Bhaumik S., Dandona L., Dandona R., Kumar G.A., Birlik S.M., Biryukov S., Casey D., Foreman K.J., Goldberg E.M., Khalil I.A., Kyu H.H., Manhertz T., Mokdad A.H., Naghavi M., Nguyen G., Nichols E., Smith M., Murray C.J.L., Roth G.A., Vos T., Ellenbogen R.G., Jakovljevic M., Tirschwell D.L., Zunt J.R., Boneya D.J., Hambisa M., Bulto L.N.B., Carabin H., Castaneda-Orjuela C.A., Catala-Lopez F., Tabares-Seisdedos R., Chen H., Chitheer A.A., Chowdhury R., Christensen H., Deveber G.A., Dharmaratne S.D., Do H.P., Nguyen C.T., Nguyen Q.L., Nguyen T.H., Nong V.M., Dokova K., Dorsey E.R., Eskandarieh S., Fischer F., Majeed A., Steiner T.J., Rawaf S., Shakir R., Shoman H., Geleijnse J.M., Gillum R.F., Gona P.N., Gugnani H.C., Gupta R., Hachinski V., Hamadeh R.R., Hankey G.J., Hareri H.A., Heydarpour P., Sahraian M.A., Kasaeian A., Malekzadeh R., Roshandel G., Sepanlou S.G., Hotez P.J., Javanbakht M., Jonas J.B., Kalkonde Y., Kandel A., Karch A., Kastor A., Rahman M., Keiyoro P.N., Khader Y.S., Khan E.A., Khang Y., Khoja A.T.A., Tran B.X., Khubchandani J., Kim D., Kim Y.J., Kivimaki M., Kokubo Y., Kosen S., Kravchenko M., Piradov M.A., Varakin Y.Y., Defo B.K., Kulkarni C., Kumar R., Larsson A., and Lavados P.M.
- Abstract
Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250.7 [95% uncertainty interval (UI) 229.1 to 274.7] million, comprising 10.2% of global DALYs) and the second-leading cause group of deaths (9.4 [9.1 to 9.7] million], comprising 16.8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505.9 [UI 1337.3 to 1681.6 million cases]), migraine (958.8 [872.1 to 1055.6] million), medication overuse headache (58.5 [50.8 to 67.4 mil
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- 2017
14. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. []
- Author
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Larsson A., Arnlov J., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Assadi R., Atey T.M., Atnafu N.T., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Ba Saleem H.O., Bacha U., Badawi A., Balakrishnan K., Banerjee A., Bannick M.S., Barac A., Barber R.M., Barker-Collo S.L., Barnighausen T., Barquera S., Barregard L., Barrero L.H., Basu S., Battista B., Battle K.E., Baune B.T., Bazargan-Hejazi S., Beardsley J., Bedi N., Beghi E., Bejot Y., Bekele B.B., Bell M.L., Bennett D.A., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhatt S., Bhutta Z.A., Biadgilign S., Bienhoff K., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Boneya D.J., Boufous S., Bourne R.R.A., Brazinova A., Brugha T.S., Buchbinder R., Bulto L.N.B., Bumgarner B.R., Butt Z.A., Cahuana-Hurtado L., Cameron E., Car M., Carabin H., Carapetis J.R., Cardenas R., Carpenter D.O., Carrero J.J., Carter A., Carvalho F., Casey D.C., Caso V., Castaneda-Orjuela C.A., Castle C.D., Catala-Lopez F., Chang H.-Y., Chang J.-C., Charlson F.J., Chen H., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Christopher D.J., Ciobanu L.G., Cirillo M., Colombara D., Cooper C., Cortesi P.A., Criqui M.H., Crump J.A., Dadi A.F., Dalal K., Dandona L., Dandona R., Das Neves J., Davitoiu D.V., De Leo D., Degenhardt L., Deiparine S., Dellavalle R.P., Deribe K., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dhillon P.K., Dicker D., Ding E.L., Djalalinia S., Do H.P., Dorsey E.R., Dos Santos K.P.B., Douwes-Schultz D., Doyle K.E., Driscoll T.R., Dubey M., Duncan B.B., El-Khatib Z.Z., Ellerstrand J., Enayati A., Endries A.Y., Ermakov S.P., Erskine H.E., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Fanuel F.B.B., Farinha C.S.E.S., Faro A., Farzadfar F., Fazeli M.S., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Fischer F., Fitzmaurice C., Flaxman A.D., Flor L.S., Foigt N., Foreman K.J., Franklin R.C., Fullman N., Furst T., Furtado J.M., Futran N.D., Gakidou E., Ganji M., Garcia-Basteiro A.L., Gebre T., Gebrehiwot T.T., Geleto A., Gemechu B.L., Gesesew H.A., Gething P.W., Ghajar A., Gibney K.B., Gill P.S., Gillum R.F., Ginawi I.A.M., Giref A.Z., Gishu M.D., Giussani G., Godwin W.W., Gold A.L., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goto A., Goulart A.C., Griswold M., Gugnani H.C., Gupta R., Gupta T., Gupta V., Hafezi-Nejad N., Hailu A.D., Hailu G.B., Hamadeh R.R., Hamidi S., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Harvey J., Hassanvand M.S., Havmoeller R., Hawley C., Hay R.J., Hay S.I., Henry N.J., Heredia-Pi I.B., Heydarpour P., Hoek H.W., Hoffman H.J., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Htet A.S., Hu G., Huang H., Huynh C., Iburg K.M., Igumbor E.U., Ikeda C., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Jassal S.K., Javanbakht M., Jayaraman S.P., Jeemon P., Jensen P.N., Jha V., Jiang G., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Kan H., Karam N.E., Karch A., Karema C.K., Kasaeian A., Kassa G.M., Kassaw N.A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kaul A., Kawakami N., Keiyoro P.N., Kengne A.P., Keren A., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khosravi A., Khubchandani J., Kieling C., Kim D., Kim P., Kim Y.J., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kivimaki M., Knudsen A.K., Kokubo Y., Kolte D., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krishnaswami S., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kumar G.A., Kumar P., Kumar S., Kyu H.H., Lal D.K., Lalloo R., Lambert N., Lan Q., Lavados P.M., Leasher J.L., Lee J.-T., Lee P.H., Leigh J., Leshargie C.T., Leung J., Leung R., Levi M., Li Y., Li Kappe D., Liang X., Liben M.L., Lim S.S., Linn S., Liu A., Liu P.Y., Liu S., Liu Y., Lodha R., Logroscino G., London S.J., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Low N., Lozano R., Lucas T.C.D., Macarayan E.R.K., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahdavi M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Manhertz T., Mantilla A., Mantovani L.G., Mapoma C.C., Marczak L.B., Martinez-Raga J., Martins-Melo F.R., Martopullo I., Marz W., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., McNellan C., Mehata S., Mehndiratta M.M., Mekonnen T.C., Memiah P., Memish Z.A., Mendoza W., Mengistie M.A., Mengistu D.T., Mensah G.A., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Mills E.J., Mirarefin M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammadi A., Mohammed K.E., Mohammed S., Mohanty S.K., Mokdad A.H., Mollenkopf S.K., Monasta L., Hernandez J.M., Montico M., Moradi-Lakeh M., Moraga P., Mori R., Morozoff C., Morrison S.D., Moses M., Mountjoy-Venning C., Mruts K.B., Mueller U.O., Muller K., Murdoch M.E., Murthy G.V.S., Musa K.I., Nachega J.B., Nagel G., Naghavi M., Naheed A., Naidoo K.S., Naldi L., Nangia V., Natarajan G., Negasa D.E., Negoi I., Negoi R.I., Newton C.R., Ngunjiri J.W., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nolte S., Nong V.M., Norrving B., Noubiap J.J.N., O'Donnell M.J., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olagunju T.O., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osgood-Zimmerman A., Osman M., Owolabi M.O., Pa M., Pacella R.E., Pana A., Panda B.K., Papachristou C., Park E.-K., Parry C.D., Parsaeian M., Patten S.B., Patton G.C., Paulson K., Pearce N., Pereira D.M., Perico N., Pesudovs K., Peterson C.B., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Plass D., Pletcher M.A., Popova S., Poulton R.G., Pourmalek F., Prabhakaran D., Prasad N., Prasad N.M., Purcell C., Qorbani M., Quansah R., Rabiee R.H.S., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Ray S.E., Reiner R.C., Reinig N., Reitsma M.B., Remuzzi G., Renzaho A.M.N., Resnikoff S., Rezaei S., Ribeiro A.L., Ronfani L., Roshandel G., Roth G.A., Roy A., Rubagotti E., Ruhago G.M., Saadat S., Sadat N., Safdarian M., Safi S., Safiri S., Sagar R., Sahathevan R., Salama J., Salomon J.A., Salvi S.S., Samy A.M., Sanabria J.R., Santomauro D., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Schmidt M.I., Schneider I.J.C., Schottker B., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Setegn T., Shackelford K.A., Shaheen A., Shaikh M.A., Shamsipour M., Shariful Islam S.M., Sharma J., Sharma R., She J., Shi P., Shields C., Shigematsu M., Shinohara Y., Shiri R., Shirkoohi R., Shirude S., Shishani K., Shrime M.G., Sibai A.M., Sigfusdottir I.D., Silva D.A.S., Silva J.P., Silveira D.G.A., Singh J.A., Singh N.P., Sinha D.N., Skiadaresi E., Skirbekk V., Slepak E.L., Sligar A., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Sorensen R.J.D., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Stein M.B., Steiner C., Steiner T.J., Steinke S., Stokes M.A., Stovner L.J., Strub B., Subart M., Sufiyan M.B., Suliankatchi Abdulkader R., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Sylte D.O., Tabares-Seisdedos R., Taffere G.R., Takala J.S., Tandon N., Tavakkoli M., Taveira N., Taylor H.R., Tehrani-Banihashemi A., Tekelab T., Temam Shifa G., Terkawi A.S., Tesfaye D.J., Tesssema B., Thamsuwan O., Thomas K.E., Tiruye T.Y., Tobe-Gai R., Tollanes M.C., Tonelli M., Topor-Madry R., Tortajada M., Touvier M., Tran B.X., Tripathi S., Troeger C., Truelsen T., Tsoi D., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varughese S., Vasankari T., Venkatesh S., Venketasubramanian N., Vidavalur R., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Wadilo F., Wakayo T., Wang Y.-P., Weaver M., Weichenthal S., Weiderpass E., Weintraub R.G., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Wiysonge C.S., Wolfe C.D.A., Woodbrook R., Woolf A.D., Workicho A., Wulf Hanson S., Xavier D., Xu G., Yadgir S., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Ye P., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., Zaki M.E.S., Zegeye E.A., Zenebe Z.M., Zhang X., Zhou M., Zipkin B., Zodpey S., Zuhlke L.J., Murray C.J.L., De Courten B., Thrift A.G., Vos T., Abajobir A.A., Abbafati C., Abbas K.M., Abate K.H., Abd-Allah F., Abdulle A.M., Abebo T.A., Abera S.F., Aboyans V., Abu-Raddad L.J., Ackerman I.N., Adamu A.A., Adetokunboh O., Afarideh M., Afshin A., Agarwal S.K., Aggarwal R., Agrawal A., Agrawal S., Ahmad Kiadaliri A., Ahmadieh H., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemi R.O., Akseer N., Al Lami F.H., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alasfoor D., Alene K.A., Ali R., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Maskari F., Al-Raddadi R., Alsharif U., Alsowaidi S., Altirkawi K.A., Amare A.T., Amini E., Ammar W., Amoako Y.A., Andersen H.H., Antonio C.A.T., Anwari P., Larsson A., Arnlov J., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Assadi R., Atey T.M., Atnafu N.T., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Ba Saleem H.O., Bacha U., Badawi A., Balakrishnan K., Banerjee A., Bannick M.S., Barac A., Barber R.M., Barker-Collo S.L., Barnighausen T., Barquera S., Barregard L., Barrero L.H., Basu S., Battista B., Battle K.E., Baune B.T., Bazargan-Hejazi S., Beardsley J., Bedi N., Beghi E., Bejot Y., Bekele B.B., Bell M.L., Bennett D.A., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Betsu B.D., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhatt S., Bhutta Z.A., Biadgilign S., Bienhoff K., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Boneya D.J., Boufous S., Bourne R.R.A., Brazinova A., Brugha T.S., Buchbinder R., Bulto L.N.B., Bumgarner B.R., Butt Z.A., Cahuana-Hurtado L., Cameron E., Car M., Carabin H., Carapetis J.R., Cardenas R., Carpenter D.O., Carrero J.J., Carter A., Carvalho F., Casey D.C., Caso V., Castaneda-Orjuela C.A., Castle C.D., Catala-Lopez F., Chang H.-Y., Chang J.-C., Charlson F.J., Chen H., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Christopher D.J., Ciobanu L.G., Cirillo M., Colombara D., Cooper C., Cortesi P.A., Criqui M.H., Crump J.A., Dadi A.F., Dalal K., Dandona L., Dandona R., Das Neves J., Davitoiu D.V., De Leo D., Degenhardt L., Deiparine S., Dellavalle R.P., Deribe K., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dhillon P.K., Dicker D., Ding E.L., Djalalinia S., Do H.P., Dorsey E.R., Dos Santos K.P.B., Douwes-Schultz D., Doyle K.E., Driscoll T.R., Dubey M., Duncan B.B., El-Khatib Z.Z., Ellerstrand J., Enayati A., Endries A.Y., Ermakov S.P., Erskine H.E., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Fanuel F.B.B., Farinha C.S.E.S., Faro A., Farzadfar F., Fazeli M.S., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Fischer F., Fitzmaurice C., Flaxman A.D., Flor L.S., Foigt N., Foreman K.J., Franklin R.C., Fullman N., Furst T., Furtado J.M., Futran N.D., Gakidou E., Ganji M., Garcia-Basteiro A.L., Gebre T., Gebrehiwot T.T., Geleto A., Gemechu B.L., Gesesew H.A., Gething P.W., Ghajar A., Gibney K.B., Gill P.S., Gillum R.F., Ginawi I.A.M., Giref A.Z., Gishu M.D., Giussani G., Godwin W.W., Gold A.L., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goto A., Goulart A.C., Griswold M., Gugnani H.C., Gupta R., Gupta T., Gupta V., Hafezi-Nejad N., Hailu A.D., Hailu G.B., Hamadeh R.R., Hamidi S., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Harvey J., Hassanvand M.S., Havmoeller R., Hawley C., Hay R.J., Hay S.I., Henry N.J., Heredia-Pi I.B., Heydarpour P., Hoek H.W., Hoffman H.J., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Htet A.S., Hu G., Huang H., Huynh C., Iburg K.M., Igumbor E.U., Ikeda C., Irvine C.M.S., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Jassal S.K., Javanbakht M., Jayaraman S.P., Jeemon P., Jensen P.N., Jha V., Jiang G., John D., Johnson C.O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kamal R., Kan H., Karam N.E., Karch A., Karema C.K., Kasaeian A., Kassa G.M., Kassaw N.A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kaul A., Kawakami N., Keiyoro P.N., Kengne A.P., Keren A., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khosravi A., Khubchandani J., Kieling C., Kim D., Kim P., Kim Y.J., Kimokoti R.W., Kinfu Y., Kisa A., Kissimova-Skarbek K.A., Kivimaki M., Knudsen A.K., Kokubo Y., Kolte D., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krishnaswami S., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kumar G.A., Kumar P., Kumar S., Kyu H.H., Lal D.K., Lalloo R., Lambert N., Lan Q., Lavados P.M., Leasher J.L., Lee J.-T., Lee P.H., Leigh J., Leshargie C.T., Leung J., Leung R., Levi M., Li Y., Li Kappe D., Liang X., Liben M.L., Lim S.S., Linn S., Liu A., Liu P.Y., Liu S., Liu Y., Lodha R., Logroscino G., London S.J., Looker K.J., Lopez A.D., Lorkowski S., Lotufo P.A., Low N., Lozano R., Lucas T.C.D., Macarayan E.R.K., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahdavi M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mamun A.A., Manguerra H., Manhertz T., Mantilla A., Mantovani L.G., Mapoma C.C., Marczak L.B., Martinez-Raga J., Martins-Melo F.R., Martopullo I., Marz W., Mathur M.R., Mazidi M., McAlinden C., McGaughey M., McGrath J.J., McKee M., McNellan C., Mehata S., Mehndiratta M.M., Mekonnen T.C., Memiah P., Memish Z.A., Mendoza W., Mengistie M.A., Mengistu D.T., Mensah G.A., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Miller T.R., Mills E.J., Mirarefin M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mitchell P.B., Mohammad K.A., Mohammadi A., Mohammed K.E., Mohammed S., Mohanty S.K., Mokdad A.H., Mollenkopf S.K., Monasta L., Hernandez J.M., Montico M., Moradi-Lakeh M., Moraga P., Mori R., Morozoff C., Morrison S.D., Moses M., Mountjoy-Venning C., Mruts K.B., Mueller U.O., Muller K., Murdoch M.E., Murthy G.V.S., Musa K.I., Nachega J.B., Nagel G., Naghavi M., Naheed A., Naidoo K.S., Naldi L., Nangia V., Natarajan G., Negasa D.E., Negoi I., Negoi R.I., Newton C.R., Ngunjiri J.W., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nolte S., Nong V.M., Norrving B., Noubiap J.J.N., O'Donnell M.J., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olagunju T.O., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osgood-Zimmerman A., Osman M., Owolabi M.O., Pa M., Pacella R.E., Pana A., Panda B.K., Papachristou C., Park E.-K., Parry C.D., Parsaeian M., Patten S.B., Patton G.C., Paulson K., Pearce N., Pereira D.M., Perico N., Pesudovs K., Peterson C.B., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Plass D., Pletcher M.A., Popova S., Poulton R.G., Pourmalek F., Prabhakaran D., Prasad N., Prasad N.M., Purcell C., Qorbani M., Quansah R., Rabiee R.H.S., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rai R.K., Rajsic S., Ram U., Ranabhat C.L., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Ray S.E., Reiner R.C., Reinig N., Reitsma M.B., Remuzzi G., Renzaho A.M.N., Resnikoff S., Rezaei S., Ribeiro A.L., Ronfani L., Roshandel G., Roth G.A., Roy A., Rubagotti E., Ruhago G.M., Saadat S., Sadat N., Safdarian M., Safi S., Safiri S., Sagar R., Sahathevan R., Salama J., Salomon J.A., Salvi S.S., Samy A.M., Sanabria J.R., Santomauro D., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Satpathy M., Sawhney M., Saxena S., Schmidt M.I., Schneider I.J.C., Schottker B., Schwebel D.C., Schwendicke F., Seedat S., Sepanlou S.G., Servan-Mori E.E., Setegn T., Shackelford K.A., Shaheen A., Shaikh M.A., Shamsipour M., Shariful Islam S.M., Sharma J., Sharma R., She J., Shi P., Shields C., Shigematsu M., Shinohara Y., Shiri R., Shirkoohi R., Shirude S., Shishani K., Shrime M.G., Sibai A.M., Sigfusdottir I.D., Silva D.A.S., Silva J.P., Silveira D.G.A., Singh J.A., Singh N.P., Sinha D.N., Skiadaresi E., Skirbekk V., Slepak E.L., Sligar A., Smith D.L., Smith M., Sobaih B.H.A., Sobngwi E., Sorensen R.J.D., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Stein M.B., Steiner C., Steiner T.J., Steinke S., Stokes M.A., Stovner L.J., Strub B., Subart M., Sufiyan M.B., Suliankatchi Abdulkader R., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Sylte D.O., Tabares-Seisdedos R., Taffere G.R., Takala J.S., Tandon N., Tavakkoli M., Taveira N., Taylor H.R., Tehrani-Banihashemi A., Tekelab T., Temam Shifa G., Terkawi A.S., Tesfaye D.J., Tesssema B., Thamsuwan O., Thomas K.E., Tiruye T.Y., Tobe-Gai R., Tollanes M.C., Tonelli M., Topor-Madry R., Tortajada M., Touvier M., Tran B.X., Tripathi S., Troeger C., Truelsen T., Tsoi D., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varughese S., Vasankari T., Venkatesh S., Venketasubramanian N., Vidavalur R., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Wadilo F., Wakayo T., Wang Y.-P., Weaver M., Weichenthal S., Weiderpass E., Weintraub R.G., Werdecker A., Westerman R., Whiteford H.A., Wijeratne T., Wiysonge C.S., Wolfe C.D.A., Woodbrook R., Woolf A.D., Workicho A., Wulf Hanson S., Xavier D., Xu G., Yadgir S., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Ye P., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., Zaki M.E.S., Zegeye E.A., Zenebe Z.M., Zhang X., Zhou M., Zipkin B., Zodpey S., Zuhlke L.J., Murray C.J.L., De Courten B., Thrift A.G., Vos T., Abajobir A.A., Abbafati C., Abbas K.M., Abate K.H., Abd-Allah F., Abdulle A.M., Abebo T.A., Abera S.F., Aboyans V., Abu-Raddad L.J., Ackerman I.N., Adamu A.A., Adetokunboh O., Afarideh M., Afshin A., Agarwal S.K., Aggarwal R., Agrawal A., Agrawal S., Ahmad Kiadaliri A., Ahmadieh H., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akinyemi R.O., Akseer N., Al Lami F.H., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alasfoor D., Alene K.A., Ali R., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Maskari F., Al-Raddadi R., Alsharif U., Alsowaidi S., Altirkawi K.A., Amare A.T., Amini E., Ammar W., Amoako Y.A., Andersen H.H., Antonio C.A.T., and Anwari P.
- Abstract
Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57.6 million (95% uncertainty interval [UI] 40.8-75.9 million [7.2%, 6.0-8.3]), 45.1 million (29.0-62.8 million [5.6%, 4.0-7.2]), 36.3 million (25.3-50.9 million [4.5%, 3.8-5.3]), 34.7 million (23.0-49.6 million [4.3%, 3.5-5.2]), and 34.1 million (23.5-46.0 million [4.2%, 3.2-5.3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2.7% (95% UI 2.3-3.1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-c
- Published
- 2017
15. Erratum: Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 (The Lancet (2017) 390(10100) (1423–1459) (S014067361732336X) (10.1016/S0140-6736(17)32336-X))
- Author
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Fullman, N, Barber, R, Abajobir, A, Abate, K, Abbafati, C, Abbas, K, Abd-Allah, F, Abdulkader, R, Abdulle, A, Abera, S, Aboyans, V, Abu-Raddad, L, Abu-Rmeileh, N, Adedeji, I, Adetokunboh, O, Afshin, A, Agrawal, A, Agrawal, S, Ahmad Kiadaliri, A, Ahmadieh, H, Ahmed, M, Aichour, M, Aichour, A, Aichour, I, Aiyar, S, Akinyemi, R, Akseer, N, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Alene, K, Alizadeh-Navaei, R, Alkerwi, A, Alla, F, Allebeck, P, Allen, C, Al-Raddadi, R, Alsharif, U, Altirkawi, K, Alvis-Guzman, N, Amare, A, Amini, E, Ammar, W, Ansari, H, Antonio, C, Anwari, P, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Asgedom, S, Assadi, R, Atey, T, Atre, S, Avila-Burgos, L, Avokpaho, E, Awasthi, A, Azzopardi, P, Bacha, U, Badawi, A, Balakrishnan, K, Bannick, M, Barac, A, Barker-Collo, S, Bärnighausen, T, Barrero, L, Basu, S, Battle, K, Baune, B, Beardsley, J, Bedi, N, Beghi, E, Béjot, Y, Bell, M, Bennett, D, Bennett, J, Bensenor, I, Berhane, A, Berhe, D, Bernabé, E, Betsu, B, Beuran, M, 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- Abstract
GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet 2017; 390: 1423–59—The full-text version of this Article has been updated so that the list of authors is displayed in the correct order, in line with the pdf version, rather than in alphabetical order. This correction has been made to the online version as of Oct 12, 2017.
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- 2017
16. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
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- Abstract
Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males
- Published
- 2017
17. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: An analysis from the Global Burden of Disease Study 2016
- Author
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K., Brugha, Traolach S., Bulto, Lemma Negesa Bulto, Butt, Zahid A., Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Carabin, Hélène, Cárdenas, Rosario, Carrero, Juan Jesus, Carter, Austin, Casey, Daniel C., Castañeda-Orjuela, Carlos A., Rivas, Jacqueline Castillo, Castro, Ruben Estanislao, Catalá-López, Ferrán, Cercy, Kelly, Chang, Hsing-Yi, Chang, Jung-Chen, Charlson, Fiona J., Chew, Adrienne, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Christensen, Hanne, Christopher, Devasahayam Jesudas, Cirillo, Massimo, Cooper, Cyrus, Criqui, Michael H., Cromwell, Elizabeth A., Crump, John A., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Das Neves, José, Davitoiu, Dragos V., De Courten, Barbora, De Steur, Hans, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, DeVeber, Gabrielle A., Ding, Eric L., Djalalinia, Shirin, Do, Huyen Phuc, Dokova, Klara, Doku, David Teye, Dorsey, E. Ray, Driscoll, Tim R., Dubey, Manisha, Duncan, Bruce Bartholow, Ebel, Beth E., Ebrahimi, Hedyeh, El-Khatib, Ziad Ziad, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Faraon, Emerito Jose Aquino, Sofia E Sa Farinha, Carla, Faro, André, Farzadfar, Farshad, Fazeli, Mir Sohail, Feigin, Valery L., Feigl, Andrea B., Fereshtehnejad, Seyed-Mohammad, Fernandes, João C., Ferrari, Alize J., Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D., Foigt, Nataliya, Foreman, Kyle J., Frank, Tahvi, Franklin, Richard C., Friedman, Joseph, Frostad, Joseph J., Fürst, Thomas, Furtado, Joao M., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M., Geleto, Ayele, Gemechu, Bikila Lencha, Gething, Peter W., Gibney, Katherine B., Gill, Paramjit Singh, Gillum, Richard F., Giref, Ababi Zergaw, Gishu, Melkamu Dedefo, Giussani, Giorgia, Glenn, Scott D., Godwin, William W., Goldberg, Ellen M., Gona, Philimon N., Goodridge, Amador, Gopalani, Sameer Vali, Goryakin, Yevgeniy, Griswold, Max, Gugnani, Harish Chander, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Hafezi-Nejad, Nima, Bidgoli, Hassan Haghparast, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hammami, Mouhanad, Hankey, Graeme J., Harb, Hilda L., Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hawley, Caitlin, Hay, Simon I., He, Jiawei, Hendrie, Delia, Henry, Nathaniel J., Heredia-Pi, Ileana Beatriz, Hoek, Hans W., Holmberg, Mollie, Horita, Nobuyuki, Hosgood, H. 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D., Lunevicius, Raimundas, Mackay, Mark T., Maddison, Emilie R., El Razek, Hassan Magdy Abd, El Razek, Mohammed Magdy Abd, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Mamun, Abdullah A., Manguerra, Helena, Mantovani, Lorenzo G., Manyazewal, Tsegahun, Mapoma, Chabila C., Marks, Guy B., Martin, Randall V., Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, Mathur, Manu Raj, Mazidi, Mohsen, McAlinden, Colm, McGaughey, Madeline, McGrath, John J., McKee, Martin, Mehata, Suresh, Mehndiratta, Man Mohan, Meier, Toni, Meles, Kidanu Gebremariam, Memish, Ziad A., Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mensah, George A., Mensink, Gert B. 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- Abstract
Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030. Methods: We used standardised GBD 2016 methods to measure 37 health-related indicators from 1990 to 2016, an increase of four indicators since GBD 2015. We substantially revised the universal health coverage (UHC) measure, which focuses on coverage of essential health services, to also represent personal health-care access and quality for several non-communicable diseases. We transformed each indicator on a scale of 0-100, with 0 as the 25th percentile estimated between 1990 and 2030, and 100 as the 975th percentile during that time. An index representing all 37 health-related SDG indicators was constructed by taking the geometric mean of scaled indicators by target. On the basis of past trends, we produced projections of indicator values, using a weighted average of the indicator and country-specific annualised rates of change from 1990 to 2016 with weights for each annual rate of change based on out-of-sample validity. 24 of the currently measured health-related SDG indicators have defined SDG targets, against which we assessed attainment. Findings Globally, the median health-related SDG index was 567 (IQR 319-668) in 2016 and country-level performance markedly varied, with Singapore (868, 95% uncertainty interval 846-889), Iceland (860, 841-876), and Sweden (856, 818-878) having the highest levels in 2016 and Afghanistan (109, 96-119), the Central African Republic (110, 88-138), and Somalia (113, 95-131) recording the lowest. Between
- Published
- 2017
18. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
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Eskandarieh, S, Farvid, M, Fereshtehnejad, S, Fischer, F, Foreman, K, Geleijnse, J, Gillum, R, Giussani, G, Gona, P, Goulart, A, Gugnani, H, Gupta, R, Hamadeh, R, Hambisa, M, Hankey, G, Hareri, H, Havmoeller, R, Hay, S, Heydarpour, P, Hotez, P, Jakovljevic, M, Javanbakht, M, Jeemon, P, Jonas, J, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, P, Khader, Y, Khalil, I, Khan, E, Khang, Y, Tawfih, A, Khoja, A, Khubchandani, J, Kim, D, Kim, Y, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, R, Defo, B, Kumar, G, Kumar, R, Kyu, H, Larsson, A, Lavados, P, Li, Y, Liang, X, Liben, M, Lo, W, Logroscino, G, Lotufo, P, Loy, C, Mackay, M, El Razek, H, El Razek, M, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, L, Massano, J, Mazidi, M, Mcalinden, C, Mehata, S, Mehndiratta, M, Memish, Z, Mendoza, W, Mengistie, M, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mishra, S, Ibrahim, N, Mohammadi, A, Mohammed, K, Mohammed, S, Mokdad, A, Moradi-Lakeh, M, Velasquez, I, 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- Abstract
Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 mil
- Published
- 2017
19. Erratum: Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 (The Lancet (2017) 390(10100) (1423–1459) (S014067361732336X) (10.1016/S0140-6736(17)32336-X))
- Author
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Fullman, Nancy, Fullman, N, Barber, R, Abajobir, A, Abate, K, Abbafati, C, Abbas, K, Abd-Allah, F, Abdulkader, R, Abdulle, A, Abera, S, Aboyans, V, Abu-Raddad, L, Abu-Rmeileh, N, Adedeji, I, Adetokunboh, O, Afshin, A, Agrawal, A, Agrawal, S, Ahmad Kiadaliri, A, Ahmadieh, H, Ahmed, M, Aichour, M, Aichour, A, Aichour, I, Aiyar, S, Akinyemi, R, Akseer, N, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Alene, K, Alizadeh-Navaei, R, Alkerwi, A, Alla, F, Allebeck, P, Allen, C, Al-Raddadi, R, Alsharif, U, Altirkawi, K, Alvis-Guzman, N, Amare, A, Amini, E, Ammar, W, Ansari, H, Antonio, C, Anwari, P, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Asgedom, S, Assadi, R, Atey, T, Atre, S, Avila-Burgos, L, Avokpaho, E, Awasthi, A, Azzopardi, P, Bacha, U, Badawi, A, Balakrishnan, K, Bannick, M, Barac, A, Barker-Collo, S, Bärnighausen, T, Barrero, L, Basu, S, Battle, K, Baune, B, Beardsley, J, Bedi, N, Beghi, E, Béjot, Y, Bell, M, Bennett, D, Bennett, J, Bensenor, I, Berhane, A, Berhe, D, Bernabé, E, Betsu, 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- Abstract
GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet 2017; 390: 1423–59—The full-text version of this Article has been updated so that the list of authors is displayed in the correct order, in line with the pdf version, rather than in alphabetical order. This correction has been made to the online version as of Oct 12, 2017.
- Published
- 2017
20. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016 : A systematic analysis for the Global Burden of Disease Study 2016
- Author
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Hay, S. I., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulle, A. M., Abebo, T. A., Abera, S. F., Aboyans, V., Abu-Raddad, L. J., Ackerman, I. N., Adedeji, I. A., Adetokunboh, O., Afshin, A., Aggarwal, R., Agrawal, S., Agrawal, A., Kiadaliri, A. A., Ahmed, M. B., Aichour, A. N., Aichour, I., Aichour, M. T. E., Aiyar, S., Akinyemiju, T. F., Akseer, N., Al Lami, F. H., Alahdab, F., Al-Aly, Z., Alam, K., Alam, N., Alam, T., Alasfoor, D., Alene, K. A., Ali, R., Alizadeh-Navaei, R., Alkaabi, J. M., Alkerwi, A., Alla, F., Allebeck, P., Allen, C., Al-Maskari, F., Almazroa, M. A., Al-Raddadi, R., Alsharif, U., Alsowaidi, S., Althouse, B. M., Altirkawi, K. A., Alvis-Guzman, N., Amare, A. T., Amini, E., Ammar, W., Amoako, Y. A., Ansha, M. G., Antonio, C. A. T., Anwari, P., Ãrnlöv, J., Arora, M., Artaman, A., Aryal, K. K., Asgedom, S. W., Atey, T. M., Atnafu, N. T., Avila-Burgos, L., Arthur Avokpaho, E. F. G., Awasthi, A., Awasthi, S., Quintanilla, B. P. 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J., Carter, A., Carvalho, F., Casey, D., Castañeda-Orjuela, C. A., Rivas, J. C., Castle, C. D., Catalá-López, F., Chang, J. -C, Charlson, F. J., Chaturvedi, P., Chen, H., Chibalabala, M., Chibueze, C. E., Chisumpa, V. H., Chitheer, A. A., Chowdhury, R., Christopher, D. J., Ciobanu, L. G., Cirillo, M., Colombara, D., Cooper, L. T., Cooper, C., Cortesi, P. A., Cortinovis, M., Criqui, M. H., Cromwell, E. A., Cross, M., Crump, J. A., Dadi, A. F., Dalal, Koustuv, Damasceno, A., Dandona, L., Dandona, R., Das Neves, J., Davitoiu, D. V., Davletov, K., De Courten, B., De Leo, D., De Steur, H., Degenhardt, L., Deiparine, S., Dellavalle, R. P., Deribe, K., Deribew, A., Das Jarlais, D. C., Dey, S., Dharmaratne, S. D., Dhillon, P. K., Dicker, D., Djalalinia, S., Do, H. P., Dokova, K., Doku, D. T., Dorsey, E. R., Dos Santos, K. P. B., Driscoll, T. R., Dubey, M., Duncan, B. B., Ebel, B. E., Echko, M., El-Khatib, Z. Z., Enayati, A., Endries, A. Y., Ermakov, S. P., Erskine, H. 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C., Montico, M., Moradi-Lakeh, M., Moraga, P., Morawska, L., Mori, R., Morrison, S. D., Moses, M., Mountjoy-Venning, C., Mruts, K. B., Mueller, U. O., Muller, K., Mudoch, M. E., Murthy, S., Murthy, G. V. S., Musa, K. I., Nachega, J. B., Nagel, G., Naghavi, M., Naheed, A., Naidoo, K. S., Nangia, V., Nasher, J. T., Natarajan, G., Negasa, D. E., Negoi, I., Negoi, R. I., Newton, C. R., Ngunjiri, J. W., Nguyen, C. T., Nguyen, Q. L., Nguyen, G., Nguyen, T. H., Nguyen, M., Nichols, E., Ningrum, D. N. A., Nong, V. M., Norheim, O. F., Norrving, B., Noubiap, J. J. N., Nyandwi, A., Obermeyer, C. M., O’Donnell, M. J., Ogbo, F. A., Oh, I. -H, Okoro, A., Oladimeji, O., Olagunju, A. T., Olagunju, T. O., Olsen, H. E., Olusanya, B. O., Olusanya, J. O., Ong, K., Opio, J. N., Oren, E., Ortiz, A., Osborne, R. H., Osgood-Zimmerman, A., Osman, M., Ota, E., Owolabi, M. O., Pa, M., Pacella, R. E., Panda, B. K., Pandian, J. D., Papachristou, C., Park, E. -K, Parry, C. D., Parsaeian, M., Patil, S. 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M., Saadat, S., Safdarian, M., Safri, S., Sagar, R., Sahathevan, R., Sahraian, M. A., Salama, J., Saleh, M. M., Salomon, J. A., Salvi, S. S., Samy, A. M., Sanabria, J. R., Sanchez-Niño, M. D., Santomauro, D., Santos, J. V., Santos, I. S., Santric Milicevic, M. M., Sartorius, B., Satpathy, M., Sawhney, M., Saxena, S., Schelonka, K., Schmidt, M. I., Schneider, I. J. C., Schöttker, B., Schutte, A. E., Schwebel, D. C., Schwendicke, F., Seedat, S., Sepanlou, S. G., Servan-Mori, E. E., Shaheen, A., Shaikh, M. A., Shamsipour, M., Shariful Islam, S. M., Sharma, R., Sharma, J., She, J., Shi, P., Shibuya, K., Shields, C., Shiferaw, M. S., Shigematsu, M., Shiri, R., Shirkoohi, R., Shirude, S., Shishani, K., Shoman, H., Siabani, S., Sibai, A. M., Sigfusdottir, I. D., Silberberg, D. H., Silva, J. P., Silva, D. A. S., Silveira, D. G. A., Singh, J. A., Singh, V., Singh, O. P., Singh, N. P., Sinha, D. N., Skiadaresi, E., Skirbekk, V., Slepak, E. L., Smith, D. L., Smith, M., Sobaih, B. H. 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G., DALYs, G B D 2 0 1 6, and Collaborators, H A L E
- Abstract
Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years, cited By 723
- Published
- 2017
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21. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016 : A systematic analysis for the Global Burden of Disease Study 2016
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- Abstract
Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3-3·1). Despite mostly stagnant age-standardised rates, the a
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22. The global burden of disease study 2013: What does it mean for the NTDs?
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Herricks, JR, Hotez, PJ, Wanga, V, Coffeng, Luc, Haagsma, Juanita, Basanez, MG, Buckle, G, Budke, CM, Carabin, H, Fevre, EM, Furst, T, Halasa, YA, King, CH, Murdoch, ME, Ramaiah, KD, Shepard, DS, Stolk, Wilma, Undurraga, EA, Stanaway, JD, Naghavi, M, Murray, CJL, Herricks, JR, Hotez, PJ, Wanga, V, Coffeng, Luc, Haagsma, Juanita, Basanez, MG, Buckle, G, Budke, CM, Carabin, H, Fevre, EM, Furst, T, Halasa, YA, King, CH, Murdoch, ME, Ramaiah, KD, Shepard, DS, Stolk, Wilma, Undurraga, EA, Stanaway, JD, Naghavi, M, and Murray, CJL
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- 2017
23. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
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Feigin, V.L., Krishnamurthi, R.V., Theadom, A.M., Abajobir, A.A., Mishra, S.R., Ahmed, M.B., Abate, K.H., Mengistie, M.A., Wakayo, T., Abd-Allah, F., Abdulle, A.M., Abera, S.F., Mohammed, K.E., Abyu, G.Y., Asgedom, S.W., Atey, T.M., Betsu, B.D., Mezgebe, H.B., Tuem, K.B., Woldu, M.A., Aichour, A.N., Aichour, I., Aichour, M.T., Akinyemi, R.O., Alabed, S., Al-Raddadi, R., Alvis-Guzman, N., Amare, A.T., Ansari, H., Anwari, P., Ärnlöv, J., Fereshtehnejad, S., Weiderpass, E., Havmoeller, R., Asayesh, H., Avila-Burgos, L., Avokpaho, E.F.G.A., Afrique, L.E.R.A.S., Azarpazhooh, M.R., Barac, A., Barboza, M., Barker-Collo, S.L., Bärnighausen, T., Farvid, M.S., Mohammed, S., Bedi, N., Beghi, E., Giussani, G., Bennett, D.A., Hay, S.I., Goulart, A.C., Santos, I.S., Bensenor, I.M., Lotufo, P.A., Berhane, A., Jeemon, P., Bhaumik, S., Dandona, L., Dandona, R., Kumar, G.A., Birlik, S.M., Biryukov, S., Casey, D., Foreman, K.J., Goldberg, E.M., Khalil, I.A., Kyu, H.H., Manhertz, T., Mokdad, A.H., Naghavi, M., Nguyen, G., Nichols, E., Smith, M., Carabin, H., Roth, G.A., Stanaway, J.D., Vos, T., Ellenbogen, R.G., Jakovljevic, M.B., Tirschwell, D.L., Zunt, J.R., Boneya, D.J., Hambisa, M., Bulto, L.N.B., Castañeda-Orjuela, C.A., Catalá-López, F., Tabarés-Seisdedos, R., Chen, H., Chitheer, A.A., Chowdhury, R., Christensen, H., Deveber, G.A., Dharmaratne, S.D., Do, H.P., Nguyen, C.T., Nguyen, Q.L., Nguyen, T.H., Nong, V.M., Sheth, K.N., Dorsey, E.R., Eskandarieh, S., Fischer, F., Majeed, A., Steiner, T.J., Rawaf, S., Shakir, R., Shoman, H., Geleijnse, J.M., Gillum, R.F., Gona, P.N., Gugnani, H.C., Gupta, R., Hachinski, V., Hamadeh, R.R., Hankey, G.J., Hareri, H.A., Heydarpour, P., Sahraian, M.A., Kasaeian, A., Malekzadeh, R., Roshandel, G., Sepanlou, S.G., Hotez, P.J., Javanbakht, M., Jonas, J.B., Kalkonde, Y., Kandel, A., Karch, A., Kastor, A., Rahman, M.H.U., Keiyoro, P.N., Khader, Y.S., Khan, E.A., Khang, Y., Khoja, A.T.A., Tran, B.X., Khubchandani, J., Kim, D., Kim, Y.J., Kivimaki, M., Kokubo, Y., Kosen, S., Kravchenko, M., Piradov, M.A., Varakin, Y.Y., Defo, B.K., Kulkarni, C., Kumar, R., Larsson, A., Lavados, P.M., Li, Y., Liang, X., Liben, M.L., Lo, W.D., Logroscino, G., Loy, C.T., Mackay, M.T., Meretoja, A., Szoeke, C.E.I., Abd El Razek, H.M., Mantovani, L.G., Massano, J., Mazidi, M., McAlinden, C., Mehata, S., Mehndiratta, M.M., Memish, Z.A., Mendoza, W., Mensah, G.A., Wijeratne, T., Miller, T.R., Mohamed Ibrahim, N., Mohammadi, A., Moradi-Lakeh, M., Velasquez, I.M., Musa, K.I., Ngunjiri, J.W., Ningrum, D.N.A., Norrving, B., Stein, D.J., Noubiap, J.J.N., Ogbo, F.A., Renzaho, A.M.N., Owolabi, M.O., Pandian, J.D., Parmar, P.G., Pereira, D.M., Petzold, M., Phillips, M.R., Poulton, R.G., Pourmalek, F., Qorbani, M., Rafay, A., Rai, R.K., Rajsic, S., Ranta, A., Rezai, M.S., Rubagotti, E., Sachdev, P., Safiri, S., Sahathevan, R., Samy, A.M., Santalucia, P., Sartorius, B., Satpathy, M., Sawhney, M., Saylan, M.I., Shaikh, M.A., Shamsizadeh, M., Shigematsu, M., Silva, D.A.S., Sobngwi, E., Sposato, L.A., Stovner, L.J., Suliankatchi Abdulkader, R., Tanne, D., Thrift, A.G., Topor-Madry, R., Truelsen, T., Ukwaja, K.N., Uthman, O.A., Yonemoto, N., Venketasubramanian, N., Vlassov, V.V., Wadilo, F., Wallin, M.T., Westerman, R., Wiysonge, C.S., Wolfe, C.D., Xavier, D., Xu, G., Yano, Y., Yimam, H.H., Yu, C., Zaidi, Z., Zaki, M.E., Feigin, V.L., Krishnamurthi, R.V., Theadom, A.M., Abajobir, A.A., Mishra, S.R., Ahmed, M.B., Abate, K.H., Mengistie, M.A., Wakayo, T., Abd-Allah, F., Abdulle, A.M., Abera, S.F., Mohammed, K.E., Abyu, G.Y., Asgedom, S.W., Atey, T.M., Betsu, B.D., Mezgebe, H.B., Tuem, K.B., Woldu, M.A., Aichour, A.N., Aichour, I., Aichour, M.T., Akinyemi, R.O., Alabed, S., Al-Raddadi, R., Alvis-Guzman, N., Amare, A.T., Ansari, H., Anwari, P., Ärnlöv, J., Fereshtehnejad, S., Weiderpass, E., Havmoeller, R., Asayesh, H., Avila-Burgos, L., Avokpaho, E.F.G.A., Afrique, L.E.R.A.S., Azarpazhooh, M.R., Barac, A., Barboza, M., Barker-Collo, S.L., Bärnighausen, T., Farvid, M.S., Mohammed, S., Bedi, N., Beghi, E., Giussani, G., Bennett, D.A., Hay, S.I., Goulart, A.C., Santos, I.S., Bensenor, I.M., Lotufo, P.A., Berhane, A., Jeemon, P., Bhaumik, S., Dandona, L., Dandona, R., Kumar, G.A., Birlik, S.M., Biryukov, S., Casey, D., Foreman, K.J., Goldberg, E.M., Khalil, I.A., Kyu, H.H., Manhertz, T., Mokdad, A.H., Naghavi, M., Nguyen, G., Nichols, E., Smith, M., Carabin, H., Roth, G.A., Stanaway, J.D., Vos, T., Ellenbogen, R.G., Jakovljevic, M.B., Tirschwell, D.L., Zunt, J.R., Boneya, D.J., Hambisa, M., Bulto, L.N.B., Castañeda-Orjuela, C.A., Catalá-López, F., Tabarés-Seisdedos, R., Chen, H., Chitheer, A.A., Chowdhury, R., Christensen, H., Deveber, G.A., Dharmaratne, S.D., Do, H.P., Nguyen, C.T., Nguyen, Q.L., Nguyen, T.H., Nong, V.M., Sheth, K.N., Dorsey, E.R., Eskandarieh, S., Fischer, F., Majeed, A., Steiner, T.J., Rawaf, S., Shakir, R., Shoman, H., Geleijnse, J.M., Gillum, R.F., Gona, P.N., Gugnani, H.C., Gupta, R., Hachinski, V., Hamadeh, R.R., Hankey, G.J., Hareri, H.A., Heydarpour, P., Sahraian, M.A., Kasaeian, A., Malekzadeh, R., Roshandel, G., Sepanlou, S.G., Hotez, P.J., Javanbakht, M., Jonas, J.B., Kalkonde, Y., Kandel, A., Karch, A., Kastor, A., Rahman, M.H.U., Keiyoro, P.N., Khader, Y.S., Khan, E.A., Khang, Y., Khoja, A.T.A., Tran, B.X., Khubchandani, J., Kim, D., Kim, Y.J., Kivimaki, M., Kokubo, Y., Kosen, S., Kravchenko, M., Piradov, M.A., Varakin, Y.Y., Defo, B.K., Kulkarni, C., Kumar, R., Larsson, A., Lavados, P.M., Li, Y., Liang, X., Liben, M.L., Lo, W.D., Logroscino, G., Loy, C.T., Mackay, M.T., Meretoja, A., Szoeke, C.E.I., Abd El Razek, H.M., Mantovani, L.G., Massano, J., Mazidi, M., McAlinden, C., Mehata, S., Mehndiratta, M.M., Memish, Z.A., Mendoza, W., Mensah, G.A., Wijeratne, T., Miller, T.R., Mohamed Ibrahim, N., Mohammadi, A., Moradi-Lakeh, M., Velasquez, I.M., Musa, K.I., Ngunjiri, J.W., Ningrum, D.N.A., Norrving, B., Stein, D.J., Noubiap, J.J.N., Ogbo, F.A., Renzaho, A.M.N., Owolabi, M.O., Pandian, J.D., Parmar, P.G., Pereira, D.M., Petzold, M., Phillips, M.R., Poulton, R.G., Pourmalek, F., Qorbani, M., Rafay, A., Rai, R.K., Rajsic, S., Ranta, A., Rezai, M.S., Rubagotti, E., Sachdev, P., Safiri, S., Sahathevan, R., Samy, A.M., Santalucia, P., Sartorius, B., Satpathy, M., Sawhney, M., Saylan, M.I., Shaikh, M.A., Shamsizadeh, M., Shigematsu, M., Silva, D.A.S., Sobngwi, E., Sposato, L.A., Stovner, L.J., Suliankatchi Abdulkader, R., Tanne, D., Thrift, A.G., Topor-Madry, R., Truelsen, T., Ukwaja, K.N., Uthman, O.A., Yonemoto, N., Venketasubramanian, N., Vlassov, V.V., Wadilo, F., Wallin, M.T., Westerman, R., Wiysonge, C.S., Wolfe, C.D., Xavier, D., Xu, G., Yano, Y., Yimam, H.H., Yu, C., Zaidi, Z., and Zaki, M.E.
- Abstract
Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 mil
- Published
- 2017
24. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
- Author
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Rabiee R.H.S., Kan H., Karch A., Karimkhani C., Kaul A., Keiyoro P.N., Lyons R.A., Keren A., Khader Y.S., Khan E.A., Khang Y.H., Won S., Khera S., Tavakkoli M., Khoja T.A.M., Khubchandani J., Kim C., Kim D., Kim Y.J., Skogen J.C., Savic M., Kokubo Y., Kolte D., McGarvey S.T., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Varakin Y.Y., Kuate Defo B., Kucuk Bicer B., Kudom A.A., Polinder S., Kuipers E.J., Lallukka T., Shiri R., Meretoja T.J., Lam H., Lam J.O., Nachega J.B., Tran B.X., Langan S.M., McKee M., Lavados P.M., Leasher J.L., Leung R., Levi M., Li Y., Liang J., Liu Y., Phillips M.R., Lloyd B.K., Logroscino G., Looker K.J., Lunevicius R., Mackay M.T., Magdy Abd El Razek M., Mahdavi M., Marcenes W., Meaney P.A., Margolis D.J., Martinez-Raga J., McMahon B.J., Mehari A., Tedla B.A., Memiah P., Memish Z.A., Mendoza W., Mhimbira F.A., Miller T.R., Mills E.J., Mohammadi A., Monasta L., Montico M., Ronfani L., Morawska L., Norman R.E., Werdecker A., Mueller U.O., Westerman R., Paternina Caicedo A.J., Murdoch M.E., Seedat S., Wiysonge C.S., Nagel G., Rothenbacher D., Naheed A., Naldi L., Nangia V., Ngalesoni F.N., Nguyen Q.L., Nkamedjie Pete P.M., Nolla J.M., Nunes B.P., Ogbo F.A., Oh I., Ohkubo T., Olivares P.R., Olusanya B.O., Olusanya J.O., Ortiz A., Ota E., Park E., Passos V.M.D.A., Patten S.B., Tonelli M., Pereira D.M., Perez-Padilla R., Pesudovs K., Pillay J.D., Plass D., Platts-Mills J.A., Pond C.D., Prasad N.M., Qorbani M., Radfar A., Rafay A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Refaat A.H., Ribeiro A.L., Rojas-Rueda D., Roy A., Sagar R., Satpathy M., Tandon N., Sahathevan R., Sanabria J.R., Sanchez-Nino M.D., Sarmiento-Suarez R., Sartorius B., Sawhney M., Schaub M.P., Schneider I.J.C., Silva D.A.S., Schottker B., Schwebel D.C., Singh J.A., Shaheen A., Shaikh M.A., Sharma R., Sharma U., Shin M., Yoon S., Sigfusdottir I.D., Silveira D.G.A., Singh O.P., Singh P.K., Soreide K., Sliwa K., Stein D.J., Soriano J.B., Sposato L.A., Sreeramareddy C.T., Stathopoulou V., Stovner L.J., Steinke S., Stroumpoulis K., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Takala J.S., Tanne D., Terkawi A.S., Tuzcu E.M., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Truelsen T., Tsala Dimbuene Z., Tsilimbaris M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., van Gool C.H., Vasankari T., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V.V., Waller S.G., Weichenthal S., White R.A., Williams H.C., Wubshet M., Xavier D., Xu G., Yan L.L., Yano Y., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zeeb H., Zuhlke L.J., Vos T., Allen C., Arora M., Barber R.M., Brown A., Carter A., Casey D.C., Charlson F.J., Chen A.Z., Coggeshall M., Cornaby L., Dandona L., Dicker D.J., Dilegge T., Erskine H.E., Ferrari A.J., Fitzmaurice C., Fleming T., Forouzanfar M.H., Fullman N., Goldberg E.M., Graetz N., Haagsma J.A., Hay S.I., Johnson C.O., Kassebaum N.J., Kawashima T., Kemmer L., Khalil I.A., Kyu H.H., Leung J., Lim S.S., Lopez A.D., Marczak L., Mokdad A.H., Naghavi M., Nguyen G., Nsoesie E., Olsen H., Pigott D.M., Pinho C., Rankin Z., Reinig N., Sandar L., Smith A., Stanaway J., Steiner C., Teeple S., Thomas B.A., Troeger C., Wagner J.A., Wang H., Wanga V., Whiteford H.A., Zoeckler L., Alexander L.T., Anderson G.M., Bell B., Bienhoff K., Biryukov S., Blore J., Brown J., Coates M.M., Daoud F., Estep K., Foreman K., Fox J., Friedman J., Frostad J., Godwin W.W., Hancock J., Huynh C., Iannarone M., Kim P., Kutz M., Masiye F., Millear A., Mirarefin M., Mooney M.D., Moradi-Lakeh M., Mullany E., Mumford J.E., Ng M., Rao P., Reitsma M.B., Reynolds A., Roth G.A., Shackelford K.A., Sivonda A., Sligar A., Sorensen R.J.D., Sur P., Vollset S.E., Woodbrook R., Zhou M., Murray C.J.L., Ellenbogen R.G., Kotsakis G.A., Mock C.N., Anderson B.O., Futran N.D., Jensen P.N., Watkins D.A., Bhutta Z.A., Nisar M.I., Akseer N., Abajobir A.A., Knibbs L.D., Lalloo R., Scott J.G., Alam N.K.M., Gouda H.N., Guo Y., McGrath J.J., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Deribew A., Ali R., Bennett D.A., Rahimi K., Kinfu Y., Duan L., Liu S., Jin Y., Wang L., Ye P., Liang X., Azzopardi P., Gibney K.B., Meretoja A., Alam K., Borschmann R., Colquhoun S.M., Patton G.C., Weintraub R.G., Szoeke C.E.I., Ademi Z., Taylor H.R., Lozano R., Campos-Nonato I.R., Campuzano J.C., Gomez-Dantes H., Heredia-Pi I.B., Mejia-Rodriguez F., Montanez Hernandez J.C., Rios Blancas M.J., Servan-Mori E.E., Mensah G.A., Salomon J.A., Thorne-Lyman A.L., Ajala O.N., Barnighausen T., Ding E.L., Farvid M.S., Wagner G.R., Osman M., Shrime M.G., Fitchett J.R.A., Abate K.H., Gebrehiwot T.T., Gebremedhin A.T., Abbafati C., Abbas K.M., Abd-Allah F., Abraham B., Abubakar I., Banerjee A., Benzian H., Abu-Raddad L.J., Abu-Rmeileh N.M., Ackerman I.N., Buchbinder R., Gabbe B., Thrift A.G., Adebiyi A.O., Akinyemi R.O., Adou A.K., Afanvi K.A., Agardh E.E., Badawi A., Popova S., Agarwal A., Ahmad Kiadaliri A., Norrving B., Ahmadieh H., Yaseri M., Jahanmehr N., Al-Aly Z., Driscoll T.R., Kemp A.H., Leigh J., Mekonnen A.B., Aldhahri S.F., Altirkawi K.A., Alegretti M.A., Alemu Z.A., Alhabib S., Alkerwi A., Alla F., Guillemin F., Allebeck P., Carrero J.J., Fereshtehnejad S.M., Weiderpass E., Havmoeller R., Al-Raddadi R., Alsharif U., Alvis-Guzman N., Amare A.T., Melaku Y.A., Ciobanu L.G., Amberbir A., Amini H., Karema C.K., Ammar W., Harb H.L., Amrock S.M., Andersen H.H., Antonio C.A.T., Aregay A.F., Betsu B.D., Hailu G.B., Yebyo H.G., Arnlov J., Larsson A., Artaman A., Asayesh H., Assadi R., Atique S., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Bacha U., Balakrishnan K., Barac A., Barker-Collo S.L., Mohammed S., Barregard L., Petzold M., Barrero L.H., Basu A., Bazargan-Hejazi S., Beghi E., Sheth K.N., Bell M.L., Huang J.J., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Wolfe C.D., Bernabe E., Hay R.J., Roba H.S., Beyene A.S., Bhala N., Piel F.B., Steiner T.J., Bhatt S., Greaves F., Majeed A., Soljak M., Biadgilign S., Bikbov B., Bjertness E., Htet A.S., Boufous S., Degenhardt L., Resnikoff S., Calabria B., Mitchell P.B., Brainin M., Brazinova A., Majdan M., Lo W.D., Shen J., Breitborde N.J.K., Buckle G.C., Butt Z.A., Lal A., Carabin H., Cardenas R., Carpenter D.O., Castaneda-Orjuela C.A., Castillo Rivas J., Catala-Lopez F., Chang J., Chiang P.P., Chibueze C.E., Chisumpa V.H., Choi J.J., Chowdhury R., Christensen H., Christopher D.J., Cirillo M., Cooper C., Cortinovis Biotech M.D., Giussani Biol G., Perico D.N., Remuzzi G., Crump J.A., Derrett S., Poulton R.G., Damtew S.A., Deribe K., Hailu A.D., Giref A.Z., Haile D., Jibat T., Taye B., Dargan P.I., das Neves J., Massano J., Santos J.V., Davey G., Davis A.C., Newton J.N., Steel N., De Leo D., Del Gobbo L.C., Dellavalle R.P., Des Jarlais D.C., Dharmaratne S.D., Dhillon P.K., Ganguly P., Zodpey S., Diaz-Torne C., Dubey M., Rahman M.H.U., Ram U., Singh A., Verma R.K., Yadav A.K., Duncan B.B., Kieling C., Schmidt M.I., Ebrahimi H., Pishgar F., Farzadfar F., Kasaeian A., Parsaeian M., Heydarpour P., Malekzadeh R., Roshandel G., Sepanlou S.G., Rahimi-Movaghar V., Elyazar I., Endres M., Endries A.Y., Ermakov S.P., Eshrati B., Farid T.A., Khan A.R., Farinha C.S.E.S., Faro A., Feigin V.L., Te Ao B.J., Kwan G.F., Felson D.T., Fernandes J.G., Fernandes J.C., Fischer F., Shiue I., Fowkes F.G.R., Franklin R.C., Furst T., Iyer V.J., Gankpe F.G., Gebre T., Geleijnse J.M., Gessner B.D., Ginawi I.A., Giroud M., Gishu M.D., Tura A.K., Glaser E., Halasa Y.A., Shepard D.S., Undurraga E.A., Gona P., Goodridge A., Gopalani S.V., Gotay C.C., Kissoon N., Kopec J.A., Pourmalek F., Goto A., Inoue M., Grainger R., Gupta R., Gupta V., Gutierrez R.A., Knudsen A.K., Norheim O.F., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Hao Y., Harikrishnan S., Haro J.M., Hoek H.W., Skirbekk V., Horino M., Horita N., Hosgood H.D., Hoy D.G., Huang H., Iburg K.M., Innos K., Kawakami N., Shibuya K., Jacobsen K.H., Jakovljevic M.B., Javanbakht M., Jayaraman S.P., Jayatilleke A.U., Jee S.H., Prabhakaran D., Jiang Y., Jimenez-Corona A., Jonas J.B., Kabir Z., Kalkonde Y., Kamal R., Kesavachandran C.N., Rabiee R.H.S., Kan H., Karch A., Karimkhani C., Kaul A., Keiyoro P.N., Lyons R.A., Keren A., Khader Y.S., Khan E.A., Khang Y.H., Won S., Khera S., Tavakkoli M., Khoja T.A.M., Khubchandani J., Kim C., Kim D., Kim Y.J., Skogen J.C., Savic M., Kokubo Y., Kolte D., McGarvey S.T., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Varakin Y.Y., Kuate Defo B., Kucuk Bicer B., Kudom A.A., Polinder S., Kuipers E.J., Lallukka T., Shiri R., Meretoja T.J., Lam H., Lam J.O., Nachega J.B., Tran B.X., Langan S.M., McKee M., Lavados P.M., Leasher J.L., Leung R., Levi M., Li Y., Liang J., Liu Y., Phillips M.R., Lloyd B.K., Logroscino G., Looker K.J., Lunevicius R., Mackay M.T., Magdy Abd El Razek M., Mahdavi M., Marcenes W., Meaney P.A., Margolis D.J., Martinez-Raga J., McMahon B.J., Mehari A., Tedla B.A., Memiah P., Memish Z.A., Mendoza W., Mhimbira F.A., Miller T.R., Mills E.J., Mohammadi A., Monasta L., Montico M., Ronfani L., Morawska L., Norman R.E., Werdecker A., Mueller U.O., Westerman R., Paternina Caicedo A.J., Murdoch M.E., Seedat S., Wiysonge C.S., Nagel G., Rothenbacher D., Naheed A., Naldi L., Nangia V., Ngalesoni F.N., Nguyen Q.L., Nkamedjie Pete P.M., Nolla J.M., Nunes B.P., Ogbo F.A., Oh I., Ohkubo T., Olivares P.R., Olusanya B.O., Olusanya J.O., Ortiz A., Ota E., Park E., Passos V.M.D.A., Patten S.B., Tonelli M., Pereira D.M., Perez-Padilla R., Pesudovs K., Pillay J.D., Plass D., Platts-Mills J.A., Pond C.D., Prasad N.M., Qorbani M., Radfar A., Rafay A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Refaat A.H., Ribeiro A.L., Rojas-Rueda D., Roy A., Sagar R., Satpathy M., Tandon N., Sahathevan R., Sanabria J.R., Sanchez-Nino M.D., Sarmiento-Suarez R., Sartorius B., Sawhney M., Schaub M.P., Schneider I.J.C., Silva D.A.S., Schottker B., Schwebel D.C., Singh J.A., Shaheen A., Shaikh M.A., Sharma R., Sharma U., Shin M., Yoon S., Sigfusdottir I.D., Silveira D.G.A., Singh O.P., Singh P.K., Soreide K., Sliwa K., Stein D.J., Soriano J.B., Sposato L.A., Sreeramareddy C.T., Stathopoulou V., Stovner L.J., Steinke S., Stroumpoulis K., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Takala J.S., Tanne D., Terkawi A.S., Tuzcu E.M., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Truelsen T., Tsala Dimbuene Z., Tsilimbaris M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., van Gool C.H., Vasankari T., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V.V., Waller S.G., Weichenthal S., White R.A., Williams H.C., Wubshet M., Xavier D., Xu G., Yan L.L., Yano Y., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zeeb H., Zuhlke L.J., Vos T., Allen C., Arora M., Barber R.M., Brown A., Carter A., Casey D.C., Charlson F.J., Chen A.Z., Coggeshall M., Cornaby L., Dandona L., Dicker D.J., Dilegge T., Erskine H.E., Ferrari A.J., Fitzmaurice C., Fleming T., Forouzanfar M.H., Fullman N., Goldberg E.M., Graetz N., Haagsma J.A., Hay S.I., Johnson C.O., Kassebaum N.J., Kawashima T., Kemmer L., Khalil I.A., Kyu H.H., Leung J., Lim S.S., Lopez A.D., Marczak L., Mokdad A.H., Naghavi M., Nguyen G., Nsoesie E., Olsen H., Pigott D.M., Pinho C., Rankin Z., Reinig N., Sandar L., Smith A., Stanaway J., Steiner C., Teeple S., Thomas B.A., Troeger C., Wagner J.A., Wang H., Wanga V., Whiteford H.A., Zoeckler L., Alexander L.T., Anderson G.M., Bell B., Bienhoff K., Biryukov S., Blore J., Brown J., Coates M.M., Daoud F., Estep K., Foreman K., Fox J., Friedman J., Frostad J., Godwin W.W., Hancock J., Huynh C., Iannarone M., Kim P., Kutz M., Masiye F., Millear A., Mirarefin M., Mooney M.D., Moradi-Lakeh M., Mullany E., Mumford J.E., Ng M., Rao P., Reitsma M.B., Reynolds A., Roth G.A., Shackelford K.A., Sivonda A., Sligar A., Sorensen R.J.D., Sur P., Vollset S.E., Woodbrook R., Zhou M., Murray C.J.L., Ellenbogen R.G., Kotsakis G.A., Mock C.N., Anderson B.O., Futran N.D., Jensen P.N., Watkins D.A., Bhutta Z.A., Nisar M.I., Akseer N., Abajobir A.A., Knibbs L.D., Lalloo R., Scott J.G., Alam N.K.M., Gouda H.N., Guo Y., McGrath J.J., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Deribew A., Ali R., Bennett D.A., Rahimi K., Kinfu Y., Duan L., Liu S., Jin Y., Wang L., Ye P., Liang X., Azzopardi P., Gibney K.B., Meretoja A., Alam K., Borschmann R., Colquhoun S.M., Patton G.C., Weintraub R.G., Szoeke C.E.I., Ademi Z., Taylor H.R., Lozano R., Campos-Nonato I.R., Campuzano J.C., Gomez-Dantes H., Heredia-Pi I.B., Mejia-Rodriguez F., Montanez Hernandez J.C., Rios Blancas M.J., Servan-Mori E.E., Mensah G.A., Salomon J.A., Thorne-Lyman A.L., Ajala O.N., Barnighausen T., Ding E.L., Farvid M.S., Wagner G.R., Osman M., Shrime M.G., Fitchett J.R.A., Abate K.H., Gebrehiwot T.T., Gebremedhin A.T., Abbafati C., Abbas K.M., Abd-Allah F., Abraham B., Abubakar I., Banerjee A., Benzian H., Abu-Raddad L.J., Abu-Rmeileh N.M., Ackerman I.N., Buchbinder R., Gabbe B., Thrift A.G., Adebiyi A.O., Akinyemi R.O., Adou A.K., Afanvi K.A., Agardh E.E., Badawi A., Popova S., Agarwal A., Ahmad Kiadaliri A., Norrving B., Ahmadieh H., Yaseri M., Jahanmehr N., Al-Aly Z., Driscoll T.R., Kemp A.H., Leigh J., Mekonnen A.B., Aldhahri S.F., Altirkawi K.A., Alegretti M.A., Alemu Z.A., Alhabib S., Alkerwi A., Alla F., Guillemin F., Allebeck P., Carrero J.J., Fereshtehnejad S.M., Weiderpass E., Havmoeller R., Al-Raddadi R., Alsharif U., Alvis-Guzman N., Amare A.T., Melaku Y.A., Ciobanu L.G., Amberbir A., Amini H., Karema C.K., Ammar W., Harb H.L., Amrock S.M., Andersen H.H., Antonio C.A.T., Aregay A.F., Betsu B.D., Hailu G.B., Yebyo H.G., Arnlov J., Larsson A., Artaman A., Asayesh H., Assadi R., Atique S., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Bacha U., Balakrishnan K., Barac A., Barker-Collo S.L., Mohammed S., Barregard L., Petzold M., Barrero L.H., Basu A., Bazargan-Hejazi S., Beghi E., Sheth K.N., Bell M.L., Huang J.J., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Wolfe C.D., Bernabe E., Hay R.J., Roba H.S., Beyene A.S., Bhala N., Piel F.B., Steiner T.J., Bhatt S., Greaves F., Majeed A., Soljak M., Biadgilign S., Bikbov B., Bjertness E., Htet A.S., Boufous S., Degenhardt L., Resnikoff S., Calabria B., Mitchell P.B., Brainin M., Brazinova A., Majdan M., Lo W.D., Shen J., Breitborde N.J.K., Buckle G.C., Butt Z.A., Lal A., Carabin H., Cardenas R., Carpenter D.O., Castaneda-Orjuela C.A., Castillo Rivas J., Catala-Lopez F., Chang J., Chiang P.P., Chibueze C.E., Chisumpa V.H., Choi J.J., Chowdhury R., Christensen H., Christopher D.J., Cirillo M., Cooper C., Cortinovis Biotech M.D., Giussani Biol G., Perico D.N., Remuzzi G., Crump J.A., Derrett S., Poulton R.G., Damtew S.A., Deribe K., Hailu A.D., Giref A.Z., Haile D., Jibat T., Taye B., Dargan P.I., das Neves J., Massano J., Santos J.V., Davey G., Davis A.C., Newton J.N., Steel N., De Leo D., Del Gobbo L.C., Dellavalle R.P., Des Jarlais D.C., Dharmaratne S.D., Dhillon P.K., Ganguly P., Zodpey S., Diaz-Torne C., Dubey M., Rahman M.H.U., Ram U., Singh A., Verma R.K., Yadav A.K., Duncan B.B., Kieling C., Schmidt M.I., Ebrahimi H., Pishgar F., Farzadfar F., Kasaeian A., Parsaeian M., Heydarpour P., Malekzadeh R., Roshandel G., Sepanlou S.G., Rahimi-Movaghar V., Elyazar I., Endres M., Endries A.Y., Ermakov S.P., Eshrati B., Farid T.A., Khan A.R., Farinha C.S.E.S., Faro A., Feigin V.L., Te Ao B.J., Kwan G.F., Felson D.T., Fernandes J.G., Fernandes J.C., Fischer F., Shiue I., Fowkes F.G.R., Franklin R.C., Furst T., Iyer V.J., Gankpe F.G., Gebre T., Geleijnse J.M., Gessner B.D., Ginawi I.A., Giroud M., Gishu M.D., Tura A.K., Glaser E., Halasa Y.A., Shepard D.S., Undurraga E.A., Gona P., Goodridge A., Gopalani S.V., Gotay C.C., Kissoon N., Kopec J.A., Pourmalek F., Goto A., Inoue M., Grainger R., Gupta R., Gupta V., Gutierrez R.A., Knudsen A.K., Norheim O.F., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Hao Y., Harikrishnan S., Haro J.M., Hoek H.W., Skirbekk V., Horino M., Horita N., Hosgood H.D., Hoy D.G., Huang H., Iburg K.M., Innos K., Kawakami N., Shibuya K., Jacobsen K.H., Jakovljevic M.B., Javanbakht M., Jayaraman S.P., Jayatilleke A.U., Jee S.H., Prabhakaran D., Jiang Y., Jimenez-Corona A., Jonas J.B., Kabir Z., Kalkonde Y., Kamal R., and Kesavachandran C.N.
- Abstract
Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60 900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9.3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year. In 2015, two causes had acute incidences in excess of 1 billion: upper respiratory infections (17.2 bi
- Published
- 2016
25. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
- Author
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Karema C.K., Kajungu D.K., Kalkonde Y., Kamal R., Kesavachandran C.N., She J., Kan H., Kandel A., Karch A., Karimkhani C., Kaul A., Kazi D.S., Keiyoro P.N., Lyons R.A., Kengne A.P., Matzopoulos R., Wiysonge C.S., Stein D.J., Mayosi B.M., Keren A., Khader Y.S., Khan E.A., Khang Y.H., Won S., Khoja T.A.M., Khubchandani J., Kim C., Kim D., Kim Y.J., Skogen J.C., Savic M., Kokubo Y., Kolte D., Koul P.A., Koyanagi A., Kuate B., Kuchenbecker R.S., Kucuk B., Kuipers E.J., Lallukka T., Shiri R., Meretoja T.J., Latif A.A., Lavados P.M., Lawrynowicz A.E.B., Leasher J.L., Leung R., Li Y., Lipshultz S.E., Wilkinson J.D., Simard E.P., Liu Y., Phillips M.R., Logroscino G., Looker K.J., Rai D., Lunevicius R., Magdy H., Mahdavi M., Malta D.C., Marcenes W., Martinez-Raga J., Mason-Jones A.J., McKee M., Murthy G.V.S., Meaney P.A., Memiah P., Memish Z.A., Mendoza W., Mhimbira F.A., Miller T.R., Mills E.J., Mirrakhimov E.M., Mohammad K.A., Mohammadi A., Monasta L., Montico M., Ronfani L., Werdecker A., Mueller U.O., Westerman R., Murdoch M.E., Nachega J.B., Tran B.X., Naheed A., Naldi L., Nangia V., Ngalesoni F.N., Nguyen Q.L., Nkamedjie P.M., Nolla J.M., Norman R.E., Obermeyer C.M., Ogbo F.A., Oh I., Oladimeji O., Sartorius B., Olivares P.R., Olusanya B.O., Olusanya J.O., Oren E., Ortiz A., Ota E., Schutte A.E., Oyekale A.S., Pa M., Park E., Patten S.B., Tonelli M., Pereira D.M., Pesudovs K., Pillay J.D., Plass D., Polinder S., Prasad N.M., Qorbani M., Radfar A., Rafay A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Raju M., Ranganathan K., Refaat A.H., Ribeiro A.L., Ricci S., Rojas-Rueda D., Sackey B.B., Sanabria J.R., Sanchez-Nino M.D., Sarmiento-Suarez R., Sawhney M., Schneider I.J.C., Silva D.A.S., Schwebel D.C., Singh J.A., Shahraz S., Shaikh M.A., Sharma R., Shigematsu M., Shin M., Yoon S., Sigfusdottir I.D., Silverberg J.I., Yano Y., Singh P.K., Soreide K., Sreeramareddy C.T., Stathopoulou V., Stein M.B., Stovner L.J., Stranges S., Stroumpoulis K., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Tanne D., Tavakkoli M., Taye B., Tuzcu E.M., Thakur J., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Truelsen T., Tsala Z., Tsilimbaris M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., van Gool C.H., van Os J., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V.V., Wallin M.T., Weichenthal S., Williams H.C., Woldeyohannes S.M., Xu G., Yakob B., Yan L.L., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zeeb H., Zuhlke L.J., Brown J., Singh A., Thrift A.G., Wang L., Kassebaum N.J., Arora M., Barber R.M., Carter A., Casey D.C., Charlson F.J., Coates M.M., Coggeshall M., Cornaby L., Dandona L., Dicker D.J., Erskine H.E., Ferrari A.J., Fitzmaurice C., Foreman K., Forouzanfar M.H., Fullman N., Goldberg E.M., Graetz N., Haagsma J.A., Hay S.I., Johnson C.O., Kemmer L., Khalil I.A., Kinfu Y., Kutz M.J., Kyu H.H., Leung J., Lim S.S., Lozano R., Mikesell J., Mokdad A.H., Mooney M.D., Naghavi M., Nguyen G., Nsoesie E., Pigott D.M., Pinho C., Rankin Z., Reinig N., Sandar L., Smith A., Sorensen R.J.D., Stanaway J., Steiner C., Teeple S., Thomas B.A., Troeger C., VanderZanden A., Wagner J.A., Wanga V., Whiteford H.A., Zhou M., Zoeckler L., Achoki T., Afshin A., Alexander L.T., Allen C., Anderson G.M., Bell B., Bienhoff K., Biryukov S., Blore J.D., Estep K., Friedman J., Frostad J., Godwin W.W., Liu P.Y., Masiye F., Millear A., Mirarefin M., Moradi-Lakeh M., Mumford J.E., Ng M., Reitsma M.B., Reynolds A., Roth G.A., Sur P.J., Vollset S.E., Vos T., Lopez A.D., Murray C.J.L., Ellenbogen R.G., Mock C.N., Anderson B.O., Futran N.D., Bhutta Z.A., Nisar M.I., Akseer N., deVeber G.A., Abajobir A.A., Knibbs L.D., Lalloo R., Alam N.K.M., Gouda H.N., Guo Y., McGrath J.J., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Ali R., Bennett D.A., Jha V., Rahimi K., Duan L., Jin Y., Ye P., Liang X., Mensah G.A., Salomon J.A., Thorne-Lyman A.L., Barnighausen T., Campos-Nonato I.R., Ding E.L., Farvid M.S., Wagner G.R., Fitchett J.R.A., Abate K.H., Ahmed M.B., Gebrehiwot T.T., Gebremedhin A.T., Abbafati C., Abbas K.M., Abd-Allah F., Abraham B., Abubakar I., Banerjee A., Abu-Raddad L.J., Abu-Rmeileh N.M., Ackerman I.N., Buchbinder R., Gabbe B., Lloyd B.K., Adebiyi A.O., Adedeji I.A., Adsuar J.C., Afanvi K.A., Agardh E.E., Badawi A., Popova S., Agarwal A., Agarwal S.K., Roy A., Sagar R., Satpathy M., Tandon N., Ahmad Kiadaliri A., Norrving B., Ahmadieh H., Yaseri M., Katibeh M., Al-Aly Z., Alam K., Azzopardi P., Borschmann R., Colquhoun S.M., Patton G.C., Weintraub R.G., Meretoja A., Szoeke C.E.I., Taylor H.R., Wijeratne T., Driscoll T.R., Leigh J., Kemp A.H., Aldhahri S.F., Altirkawi K.A., Terkawi A.S., Alegretti M.A., Aleman A.V., Cavalleri F., Colistro V., Alemu Z.A., Tegegne T.K., Alkerwi A., Alla F., Allebeck P., Rabiee R.H.S., Carrero J.J., Fereshtehnejad S.M., Kivipelto M., Weiderpass E., Havmoeller R., Sindi S., Alsharif U., Alvarez E., Alvis-Guzman N., Amare A.T., Melaku Y.A., Ciobanu L.G., Tessema G.A., Amberbir A., Amegah A.K., Ameh E.A., Amini H., Furst T., Ammar W., Harb H.L., Amrock S.M., Zonies D., Antonio C.A.T., Anwari P., Arnlov J., Larsson A., Arsic V.S., Barac A., Artaman A., Asayesh H., Asghar R.J., Avokpaho E.F.G.A., Gankpe F.G., Awasthi A., Ayala B.P., Bacha U., Balakrishnan K., Barker-Collo S.L., Mohammed S., Barregard L., Petzold M., Barrero L.H., Basu S., Del L.C., Bayou T.A., Betsu B.D., Hailu G.B., Tekle D.Y., Beardsley J., Bedi N., Beghi E., Sheth K.N., Bell M.L., Huang J.J., Benjet C., Gutierrez R.A., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Wolfe C.D., Bernabe E., Hay R.J., Roba H.S., Beyene A.S., Hassen T.A., Mesfi Y.M., Bhala N., Bhansali A., Piel F.B., Steiner T.J., Bhatt S., Majeed A., Soljak M., Biadgilign S., Bikbov B., Bin A.A., Bjertness E., Bourne R.R.A., Brainin M., Brazinova A., Majdan M., Shen J., Breitborde N.J.K., Brenner H., Brugha T.S., Buckle G.C., Butt Z.A., Calabria B., Lucas R.M., Boufous S., Degenhardt L., Resnikoff S., Mitchell P.B., Campuzano J.C., Gomez-Dantes H., Heredia-Pi I.B., Jauregui A., Montanez Hernandez J.C., Servan-Mori E.E., Carabin H., Carapetis J.R., Cardenas R., Castaneda-Orjuela C.A., Castillo Rivas J., Catala-Lopez F., Chang J., Chiang P.P., Chibalabala M., Chibueze C.E., Mori R., Chisumpa V.H., Choi J.J., Choudhury L., Christensen H., Colomar M., Crump J.A., Derrett S., Poulton R.G., Giussani G., Cortinovis M., Perico N., Remuzzi G., Dargan P.I., das Neves J., Pedro J.M., Santos J.V., Davey G., Davis A.C., Newton J.N., Steel N., De Leo D., Des Jarlais D.C., Dharmaratne S.D., Dhillon P.K., Zodpey S., Doyle K.E., Dubey M., Rahman M.H.U., Ram U., Yadav A.K., Duncan B.B., Kieling C., Schmidt M.I., Ebrahimi H., Esteghamati A., Farzadfar F., Hafezi-Nejad N., Kasaeian A., Parsaeian M., Pishgar F., Sheikhbahaei S., Fahimi S., Malekzadeh R., Roshandel G., Sepanlou S.G., Hassanvand M.S., Heydarpour P., Rahimi-Movaghar V., Elyazar I., Endries A.Y., Ermakov S.P., Eshrati B., Farid T.A., Khan A.R., Farinha C.S.E.S., Faro A., Feigin V.L., Te B.J., Fernandes J.G., Fernandes J.C., Fischer F., Foigt N., Fowkes F.G.R., Franklin R.C., Garcia-Basteiro A.L., Geleijnse J.M., Jibat T., Gibney K.B., Gillum R.F., Mehari A., Ginawi I.A., Hailu A.D., Giref A.Z., Haile D., Giroud M., Gishu M.D., Tura A.K., Gona P., Goodridge A., Gopalani S.V., Gotay C.C., Kissoon N., Kopec J.A., Pourmalek F., Goto A., Inoue M., Gugnani H., Gupta R., Gupta V., Knudsen A.K., Norheim O.F., Halasa Y.A., Undurraga E.A., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Harikrishnan S., Haro J.M., Hedayati M.T., Hoek H.W., Skirbekk V., Hoff D.J., Horino M., Horita N., Hosgood H.D., Hoy D.G., Hsairi M., Huang H., Iburg K.M., Idrisov B.T., Kwan G.F., Innos K., Kawakami N., Shibuya K., Jacobsen K.H., Jayatilleke A.U., Jiang G., Jiang Y., Jimenez-Corona A., Jonas J.B., Kabir Z., Karema C.K., Kajungu D.K., Kalkonde Y., Kamal R., Kesavachandran C.N., She J., Kan H., Kandel A., Karch A., Karimkhani C., Kaul A., Kazi D.S., Keiyoro P.N., Lyons R.A., Kengne A.P., Matzopoulos R., Wiysonge C.S., Stein D.J., Mayosi B.M., Keren A., Khader Y.S., Khan E.A., Khang Y.H., Won S., Khoja T.A.M., Khubchandani J., Kim C., Kim D., Kim Y.J., Skogen J.C., Savic M., Kokubo Y., Kolte D., Koul P.A., Koyanagi A., Kuate B., Kuchenbecker R.S., Kucuk B., Kuipers E.J., Lallukka T., Shiri R., Meretoja T.J., Latif A.A., Lavados P.M., Lawrynowicz A.E.B., Leasher J.L., Leung R., Li Y., Lipshultz S.E., Wilkinson J.D., Simard E.P., Liu Y., Phillips M.R., Logroscino G., Looker K.J., Rai D., Lunevicius R., Magdy H., Mahdavi M., Malta D.C., Marcenes W., Martinez-Raga J., Mason-Jones A.J., McKee M., Murthy G.V.S., Meaney P.A., Memiah P., Memish Z.A., Mendoza W., Mhimbira F.A., Miller T.R., Mills E.J., Mirrakhimov E.M., Mohammad K.A., Mohammadi A., Monasta L., Montico M., Ronfani L., Werdecker A., Mueller U.O., Westerman R., Murdoch M.E., Nachega J.B., Tran B.X., Naheed A., Naldi L., Nangia V., Ngalesoni F.N., Nguyen Q.L., Nkamedjie P.M., Nolla J.M., Norman R.E., Obermeyer C.M., Ogbo F.A., Oh I., Oladimeji O., Sartorius B., Olivares P.R., Olusanya B.O., Olusanya J.O., Oren E., Ortiz A., Ota E., Schutte A.E., Oyekale A.S., Pa M., Park E., Patten S.B., Tonelli M., Pereira D.M., Pesudovs K., Pillay J.D., Plass D., Polinder S., Prasad N.M., Qorbani M., Radfar A., Rafay A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Raju M., Ranganathan K., Refaat A.H., Ribeiro A.L., Ricci S., Rojas-Rueda D., Sackey B.B., Sanabria J.R., Sanchez-Nino M.D., Sarmiento-Suarez R., Sawhney M., Schneider I.J.C., Silva D.A.S., Schwebel D.C., Singh J.A., Shahraz S., Shaikh M.A., Sharma R., Shigematsu M., Shin M., Yoon S., Sigfusdottir I.D., Silverberg J.I., Yano Y., Singh P.K., Soreide K., Sreeramareddy C.T., Stathopoulou V., Stein M.B., Stovner L.J., Stranges S., Stroumpoulis K., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Tanne D., Tavakkoli M., Taye B., Tuzcu E.M., Thakur J., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Truelsen T., Tsala Z., Tsilimbaris M., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., van Gool C.H., van Os J., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V.V., Wallin M.T., Weichenthal S., Williams H.C., Woldeyohannes S.M., Xu G., Yakob B., Yan L.L., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zeeb H., Zuhlke L.J., Brown J., Singh A., Thrift A.G., Wang L., Kassebaum N.J., Arora M., Barber R.M., Carter A., Casey D.C., Charlson F.J., Coates M.M., Coggeshall M., Cornaby L., Dandona L., Dicker D.J., Erskine H.E., Ferrari A.J., Fitzmaurice C., Foreman K., Forouzanfar M.H., Fullman N., Goldberg E.M., Graetz N., Haagsma J.A., Hay S.I., Johnson C.O., Kemmer L., Khalil I.A., Kinfu Y., Kutz M.J., Kyu H.H., Leung J., Lim S.S., Lozano R., Mikesell J., Mokdad A.H., Mooney M.D., Naghavi M., Nguyen G., Nsoesie E., Pigott D.M., Pinho C., Rankin Z., Reinig N., Sandar L., Smith A., Sorensen R.J.D., Stanaway J., Steiner C., Teeple S., Thomas B.A., Troeger C., VanderZanden A., Wagner J.A., Wanga V., Whiteford H.A., Zhou M., Zoeckler L., Achoki T., Afshin A., Alexander L.T., Allen C., Anderson G.M., Bell B., Bienhoff K., Biryukov S., Blore J.D., Estep K., Friedman J., Frostad J., Godwin W.W., Liu P.Y., Masiye F., Millear A., Mirarefin M., Moradi-Lakeh M., Mumford J.E., Ng M., Reitsma M.B., Reynolds A., Roth G.A., Sur P.J., Vollset S.E., Vos T., Lopez A.D., Murray C.J.L., Ellenbogen R.G., Mock C.N., Anderson B.O., Futran N.D., Bhutta Z.A., Nisar M.I., Akseer N., deVeber G.A., Abajobir A.A., Knibbs L.D., Lalloo R., Alam N.K.M., Gouda H.N., Guo Y., McGrath J.J., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Ali R., Bennett D.A., Jha V., Rahimi K., Duan L., Jin Y., Ye P., Liang X., Mensah G.A., Salomon J.A., Thorne-Lyman A.L., Barnighausen T., Campos-Nonato I.R., Ding E.L., Farvid M.S., Wagner G.R., Fitchett J.R.A., Abate K.H., Ahmed M.B., Gebrehiwot T.T., Gebremedhin A.T., Abbafati C., Abbas K.M., Abd-Allah F., Abraham B., Abubakar I., Banerjee A., Abu-Raddad L.J., Abu-Rmeileh N.M., Ackerman I.N., Buchbinder R., Gabbe B., Lloyd B.K., Adebiyi A.O., Adedeji I.A., Adsuar J.C., Afanvi K.A., Agardh E.E., Badawi A., Popova S., Agarwal A., Agarwal S.K., Roy A., Sagar R., Satpathy M., Tandon N., Ahmad Kiadaliri A., Norrving B., Ahmadieh H., Yaseri M., Katibeh M., Al-Aly Z., Alam K., Azzopardi P., Borschmann R., Colquhoun S.M., Patton G.C., Weintraub R.G., Meretoja A., Szoeke C.E.I., Taylor H.R., Wijeratne T., Driscoll T.R., Leigh J., Kemp A.H., Aldhahri S.F., Altirkawi K.A., Terkawi A.S., Alegretti M.A., Aleman A.V., Cavalleri F., Colistro V., Alemu Z.A., Tegegne T.K., Alkerwi A., Alla F., Allebeck P., Rabiee R.H.S., Carrero J.J., Fereshtehnejad S.M., Kivipelto M., Weiderpass E., Havmoeller R., Sindi S., Alsharif U., Alvarez E., Alvis-Guzman N., Amare A.T., Melaku Y.A., Ciobanu L.G., Tessema G.A., Amberbir A., Amegah A.K., Ameh E.A., Amini H., Furst T., Ammar W., Harb H.L., Amrock S.M., Zonies D., Antonio C.A.T., Anwari P., Arnlov J., Larsson A., Arsic V.S., Barac A., Artaman A., Asayesh H., Asghar R.J., Avokpaho E.F.G.A., Gankpe F.G., Awasthi A., Ayala B.P., Bacha U., Balakrishnan K., Barker-Collo S.L., Mohammed S., Barregard L., Petzold M., Barrero L.H., Basu S., Del L.C., Bayou T.A., Betsu B.D., Hailu G.B., Tekle D.Y., Beardsley J., Bedi N., Beghi E., Sheth K.N., Bell M.L., Huang J.J., Benjet C., Gutierrez R.A., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Wolfe C.D., Bernabe E., Hay R.J., Roba H.S., Beyene A.S., Hassen T.A., Mesfi Y.M., Bhala N., Bhansali A., Piel F.B., Steiner T.J., Bhatt S., Majeed A., Soljak M., Biadgilign S., Bikbov B., Bin A.A., Bjertness E., Bourne R.R.A., Brainin M., Brazinova A., Majdan M., Shen J., Breitborde N.J.K., Brenner H., Brugha T.S., Buckle G.C., Butt Z.A., Calabria B., Lucas R.M., Boufous S., Degenhardt L., Resnikoff S., Mitchell P.B., Campuzano J.C., Gomez-Dantes H., Heredia-Pi I.B., Jauregui A., Montanez Hernandez J.C., Servan-Mori E.E., Carabin H., Carapetis J.R., Cardenas R., Castaneda-Orjuela C.A., Castillo Rivas J., Catala-Lopez F., Chang J., Chiang P.P., Chibalabala M., Chibueze C.E., Mori R., Chisumpa V.H., Choi J.J., Choudhury L., Christensen H., Colomar M., Crump J.A., Derrett S., Poulton R.G., Giussani G., Cortinovis M., Perico N., Remuzzi G., Dargan P.I., das Neves J., Pedro J.M., Santos J.V., Davey G., Davis A.C., Newton J.N., Steel N., De Leo D., Des Jarlais D.C., Dharmaratne S.D., Dhillon P.K., Zodpey S., Doyle K.E., Dubey M., Rahman M.H.U., Ram U., Yadav A.K., Duncan B.B., Kieling C., Schmidt M.I., Ebrahimi H., Esteghamati A., Farzadfar F., Hafezi-Nejad N., Kasaeian A., Parsaeian M., Pishgar F., Sheikhbahaei S., Fahimi S., Malekzadeh R., Roshandel G., Sepanlou S.G., Hassanvand M.S., Heydarpour P., Rahimi-Movaghar V., Elyazar I., Endries A.Y., Ermakov S.P., Eshrati B., Farid T.A., Khan A.R., Farinha C.S.E.S., Faro A., Feigin V.L., Te B.J., Fernandes J.G., Fernandes J.C., Fischer F., Foigt N., Fowkes F.G.R., Franklin R.C., Garcia-Basteiro A.L., Geleijnse J.M., Jibat T., Gibney K.B., Gillum R.F., Mehari A., Ginawi I.A., Hailu A.D., Giref A.Z., Haile D., Giroud M., Gishu M.D., Tura A.K., Gona P., Goodridge A., Gopalani S.V., Gotay C.C., Kissoon N., Kopec J.A., Pourmalek F., Goto A., Inoue M., Gugnani H., Gupta R., Gupta V., Knudsen A.K., Norheim O.F., Halasa Y.A., Undurraga E.A., Hamadeh R.R., Hamidi S., Hammami M., Handal A.J., Hankey G.J., Harikrishnan S., Haro J.M., Hedayati M.T., Hoek H.W., Skirbekk V., Hoff D.J., Horino M., Horita N., Hosgood H.D., Hoy D.G., Hsairi M., Huang H., Iburg K.M., Idrisov B.T., Kwan G.F., Innos K., Kawakami N., Shibuya K., Jacobsen K.H., Jayatilleke A.U., Jiang G., Jiang Y., Jimenez-Corona A., Jonas J.B., and Kabir Z.
- Abstract
Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates d
- Published
- 2016
26. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.
- Author
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Nguhiu P., Shigematsu M., Shin M., Yoon S., Shiri R., Shishani K., Sigfusdottir I.D., Silverberg J.I., Yano Y., Singh O.P., Singh P.K., Soreide K., Soriano J.B., Sposato L.A., Sreeramareddy C.T., Stahl H., Stathopoulou V., Steckling N., Stranges S., Strong M., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Tabb K.M., Talongwa R.T., Tarawneh M.R., Tavakkoli M., Taye B., Tuzcu E.M., Thakur J., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Tsala Dimbuene Z., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V.V., Volkow P., Wallin M.T., Weichenthal S., Woolf A.D., Wubshet M., Xu G., Yakob B., Yan L.L., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zambrana-Torrelio C., Zapata T., Zonies D., Singh A., Thrift A.G., Wang L., Lim S.S., Allen K., Dandona L., Forouzanfar M.H., Fullman N., Goldberg E.M., Hay S.I., Holmberg M., Kutz M.J., Larson H.J., Lopez A.D., McNellan C.R., Mokdad A.H., Mooney M.D., Naghavi M., Olsen H.E., Pigott D.M., Vos T., Wang H., Achoki T., Afshin A., Allen C., Anderson G.M., Barber R., Bienhoff K.A., Blore J., Brauer M., Carter A., Casey D., Charlson F.J., Chen A.Z., Coates M.M., Coggeshall M., Cohen A.J., Deshpande A., Erskine H.E., Ferrari A.J., Fitzmaurice C., Foreman K., Fraser M., Friedman J., Frostad J., Godwin W., Graetz N., Griswold M., Haagsma J.A., Haakenstad A., Kassebaum N.J., Kemmer L., Kulikoff X.R., Kyu H.H., Leung J., Lind M., Liu P.Y., Masiye F., Mirarefin M., Misganaw A., Moradi-Lakeh M., Nguyen G., Pinho C., Rao P.C., Reitsma M.B., Roth G.A., Santomauro D.F., Shackelford K., Silpakit N., Sligar A., Sorensen R.J.D., Stanaway J.D., Steiner C., Sur P., Vollset S.E., Wanga V., Whiteford H.A., Zhao Y., Zhou M., Murray C.J.L., Kotsakis G.A., Mock C.N., Anderson B.O., Watkins D.A., Bhutta Z.A., Nisar M.I., Akseer N., deVeber G.A., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Cooper 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Kuate Defo B., Kuchenbecker R.S., Kuipers E.J., Kulkarni V.S., Lal A., Lucas R.M., Lam H., Lan Q., Laryea D.O., Latif A.A., Leasher J.L., Leinsalu M., Leung R., Levi M., Linn S., Lipshultz S.E., Wilkinson J.D., Simard E.P., Liu Y., Phillips M.R., Lloyd B.K., Lo L., Logroscino G., Lunevicius R., Magdy M., Magis-Rodriguez C., Mahdavi M., Malta D.C., Meaney P.A., Margolis D.J., Martinez-Raga J., Mason-Jones A.J., Tedla B.A., Memiah P., Memish Z.A., Mendoza W., Mensink G.B.M., Meretoja T.J., Mhimbira F.A., Miller T.R., Mills E.J., Mohammadi A., Monasta L., Montico M., Ronfani L., Monis J.D., Morawska L., Sun J., Mori R., Werdecker A., Mueller U.O., Westerman R., Murdoch M.E., Murimira B., Murray J., Musa K.I., Nachega J.B., Seedat S., Tran B.X., Nagel G., Rothenbacher D., Naidoo K.S., Oladimeji O., Sartorius B., Zegeye E.A., Naldi L., Remuzzi G., Nangia V., Nejjari C., Newton C.R., Ngalesoni F.N., Nguyen Q.L., Nkamedjie P.M., Nolte S., Osborne R.H., Nomura M., Norheim O.F., Obermeyer C.M., Ogbo F.A., Oh I., Olivares P.R., Olusanya B.O., Olusanya J.O., Opio J.N., Oren E., Ortiz A., Ota E., Mahesh P.A., Park E., Park H., Patel T., Patil S.T., Patten S.B., Tonelli M., Paudel D., Pereira D.M., Perico N., Pesudovs K., Petzold M., Pillay J.D., Polinder S., Qorbani M., Radfar A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Raju M., Rana S.M., Ranabhat C.L., Ranganathan K., Refaat A.H., Ribeiro A.L., Rojas-Rueda D., Roy A., Sagar R., Satpathy M., Sackey B.B., Saleh M.M., Sanabria J.R., Sarmiento-Suarez R., Savic M., Sawhney M., Schmidhuber J., Schneider I.J.C., Silva D.A.S., Schutte A.E., Shaheen A., Shaikh M.A., Sharma R., Nguhiu P., Shigematsu M., Shin M., Yoon S., Shiri R., Shishani K., Sigfusdottir I.D., Silverberg J.I., Yano Y., Singh O.P., Singh P.K., Soreide K., Soriano J.B., Sposato L.A., Sreeramareddy C.T., Stahl H., Stathopoulou V., Steckling N., Stranges S., Strong M., Sunguya B.F., Swaminathan S., Sykes B.L., Tabares-Seisdedos R., Tabb K.M., Talongwa R.T., Tarawneh M.R., Tavakkoli M., Taye B., Tuzcu E.M., Thakur J., Thomson A.J., Thurston G.D., Tobe-Gai R., Topor-Madry R., Topouzis F., Tsala Dimbuene Z., Tyrovolas S., Ukwaja K.N., Uneke C.J., Uthman O.A., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V.V., Volkow P., Wallin M.T., Weichenthal S., Woolf A.D., Wubshet M., Xu G., Yakob B., Yan L.L., Yip P., Yonemoto N., Younis M.Z., Yu C., Zaidi Z., Zaki M.E., Zambrana-Torrelio C., Zapata T., Zonies D., Singh A., Thrift A.G., Wang L., Lim S.S., Allen K., Dandona L., Forouzanfar M.H., Fullman N., Goldberg E.M., Hay S.I., Holmberg M., Kutz M.J., Larson H.J., Lopez A.D., McNellan C.R., Mokdad A.H., Mooney M.D., Naghavi M., Olsen H.E., Pigott D.M., Vos T., Wang H., Achoki T., Afshin A., Allen C., Anderson G.M., Barber R., Bienhoff K.A., Blore J., Brauer M., Carter A., Casey D., Charlson F.J., Chen A.Z., Coates M.M., Coggeshall M., Cohen A.J., Deshpande A., Erskine H.E., Ferrari A.J., Fitzmaurice C., Foreman K., Fraser M., Friedman J., Frostad J., Godwin W., Graetz N., Griswold M., Haagsma J.A., Haakenstad A., Kassebaum N.J., Kemmer L., Kulikoff X.R., Kyu H.H., Leung J., Lind M., Liu P.Y., Masiye F., Mirarefin M., Misganaw A., Moradi-Lakeh M., Nguyen G., Pinho C., Rao P.C., Reitsma M.B., Roth G.A., Santomauro D.F., Shackelford K., Silpakit N., Sligar A., Sorensen R.J.D., Stanaway J.D., Steiner C., Sur P., Vollset S.E., Wanga V., Whiteford H.A., Zhao Y., Zhou M., Murray C.J.L., Kotsakis G.A., Mock C.N., Anderson B.O., Watkins D.A., Bhutta Z.A., Nisar M.I., Akseer N., deVeber G.A., Jeemon P., Dandona R., Kumar G.A., Gething P.W., Bisanzio D., Cooper C., Ali R., Bennett D.A., Jha V., Weiss D.J., Kinfu Y., Patel V., Langan S.M., McKee M., Murthy G.V.S., Roberts B., Stockl H., Duan L., Jin Y., Li Y., Liu S., Ye P., Liang X., Azzopardi P., Cowie B.C., Meretoja A., Patton G.C., Alam K., Weintraub R.G., Sawyer S.M., Szoeke C.E.I., Taylor H.R., Lozano R., Barrientos-Gutierrez T., Campos-Nonato I.R., Campuzano J.C., Heredia-Pi I.B., Montanez Hernandez J.C., Rios Blancas M.J., Servan-Mori E.E., Shamah Levy T., Salomon J.A., Binagwaho A., Barnighausen T., Cahill L.E., Ding E.L., Farvid M.S., Wagner G.R., Thorne-Lyman A.L., James P., Fitchett J.R.A., Abajobir A.A., Knibbs L.D., Veerman J.L., Lalloo R., Gouda H.N., Guo Y., McGrath J.J., Abate K.H., Gebrehiwot T.T., Gebremedhin A.T., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abraham B., Abubakar I., Aldridge R.W., Banerjee A., Benzian H., Tillmann T., Abu-Raddad L.J., Abu-Rmeileh N.M., Melaku Y.A., Abyu G.Y., Bayou T.A., Betsu B.D., Gebru A.A., Hailu G.B., Tekle D.Y., Yalew A.Z., Adebiyi A.O., Owolabi M.O., Akinyemi R.O., Adedeji I.A., Afanvi K.A., Micha R., Shi P., Singh G.M., Badawi A., Agarwal A., Agrawal A., Ahmad Kiadaliri A., Norrving B., Ahmadieh H., Yaseri M., Jahanmehr N., Ahmed K.Y., Alemu Z.A., Tegegne T.K., Akanda A.S., Akinyemiju T.F., Schwebel D.C., Singh J.A., Al-Aly Z., Driscoll T.R., Leigh J., Mekonnen A.B., Neal B., Alam U., Alasfoor D., AlBuhairan F.S., Alkhateeb M.A., Aldhahri S.F., Altirkawi K.A., Terkawi A.S., Alkerwi A., Alla F., Allebeck P., Rabiee R.H.S., Roy N., Kivipelto M., Carrero J.J., Fereshtehnejad S.M., Weiderpass E., Havmoeller R., Sindi S., Al-Raddadi R., Alvarez E., Alvis-Guzman N., Paternina Caicedo A.J., Amare A.T., Ciobanu L.G., Tessema G.A., Amberbir A., Amegah A.K., Amini H., Furst T., Karema C.K., Ammar W., Harb H.L., Amrock S.M., Andersen H.H., Antonio C.A.T., Anwari P., Arnlov J., Larsson A., Artaman A., Asayesh H., Asghar R.J., Atique S., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Bacha U., Balakrishnan K., Barac A., Barker-Collo S.L., Mohammed S., Barrero L.H., Basu S., Del L.C., Bazargan-Hejazi S., Beardsley J., Bedi N., Beghi E., Bejot Y., Sheth K.N., Bell M.L., Bello A.K., Santos I.S., Bensenor I.M., Lotufo P.A., Berhane A., Wolfe C.D., Bernabe E., Wolfe I., Bernal O.A., Roba H.S., Beyene A.S., Mesfin Y.M., Bhala N., Bhatt S., Biadgilign S., Bikbov B., Soneji S., Bjertness E., Htet A.S., Bourne R.R.A., Brainin M., Krueger H., Gotay C.C., Kissoon N., Murthy S., Pourmalek F., Brazinova A., Majdan M., Shen J., Breitborde N.J.K., Broday D.M., Brugha T.S., Buchbinder R., Gabbe B., Butt Z.A., van Donkelaar A., Martin R.V., Carabin H., Cardenas R., Caso V., Castaneda-Orjuela C.A., Castillo Rivas J., Catala-Lopez F., Cavalleri F., Cecilio P., das Neves J., Massano J., Pedro J.M., Chang H., Chang J., Che X., Chiang P.P., Chibalabala M., Chisumpa V.H., Mapoma C.C., Choi J.J., Chowdhury R., Christensen H., Cirillo M., Piel F.B., Rodriguez A., Cooke G.S., Majeed A., Cooper L.T., Crump J.A., Derrett S., Poulton R.G., Damtew S.A., Workie S.B., Deribe K., Tefera W., Giref A.Z., Haile D., Temam Shifa G., Dargan P.I., Davis A.C., Newton J.N., Steel N., Davletov K., de Castro E.F., De Leo D., Degenhardt L., Resnikoff S., Mitchell P.B., Des Jarlais D.C., Dey S., Dhillon P.K., Lal D.K., Zodpey S., Dharmaratne S.D., Dorsey E.R., Doyle K.E., Kemp A.H., Dubey M., Rahman M.H.U., Ram U., Verma R.K., Yadav A.K., Duncan B.B., Kieling C., Schmidt M.I., Ebrahimi H., Esteghamati A., Farzadfar F., Hafezi-Nejad N., Kasaeian A., Parsaeian M., Pishgar F., Sheikhbahaei S., Fahimi S., Malekzadeh R., Roshandel G., Sepanlou S.G., Hassanvand M.S., Khosravi A., Rahimi-Movaghar V., Endries A.Y., Ermakov S.P., Soshnikov S., Eshrati B., Farid T.A., Khan A.R., Farinha C.S.E.S., Faro A., Feigin V.L., Felicio M.M., Fernandes J.C., Fischer F., Foigt N., Shiue I., Fowkes F.G.R., Franca E.B., Franklin R.C., Garcia-Basteiro A.L., Gebre T., Gessner B.D., Gillum R.F., Mehari A., Ginawi I.A., Giroud M., Gishu M.D., Tura A.K., Gona P., Goodridge A., Gopalani S.V., Goto A., Inoue M., Greenwell K.F., Gupta R., Gupta V., Gutierrez R.A., Gyawali B., Iburg K.M., Halasa Y.A., Undurraga E.A., Hamadeh R.R., Hamidi S., Hammami M., Hankey G.J., Haro J.M., Hoek H.W., Skirbekk V., Horino M., Horita N., Hosgood H.D., Hoy D.G., Hu G., Huang H., Idrisov B.T., Kwan G.F., Kawakami N., Shibuya K., Islami F., Jacobs T.A., Jacobsen K.H., Jakovljevic M.B., Jansen H.A.F., Javanbakht M., Jayatilleke A.U., Jee S.H., Jiang Y., Jibat T., Jonas J.B., Kabir Z., Kalkonde Y., Kamal R., Kesavachandran C.N., She J., Kan H., Kandel A., Karch A., Karimkhani C., Karunapema P., Kaul A., Kayibanda J.F., Keiyoro P.N., Matzopoulos R., Parry C.D., Kengne A.P., Wiysonge C.S., Stein D.J., Mayosi B.M., Shey M., Keren A., Khader Y.S., Khan E.A., Khan G., Khang Y.H., Won S., Khoja T.A.M., Khubchandani J., Kim C., Kim D., Kim S., Kim Y.J., Kimokoti R.W., Kokubo Y., Kolte D., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Varakin Y.Y., Kuate Defo B., Kuchenbecker R.S., Kuipers E.J., Kulkarni V.S., Lal A., Lucas R.M., Lam H., Lan Q., Laryea D.O., Latif A.A., Leasher J.L., Leinsalu M., Leung R., Levi M., Linn S., Lipshultz S.E., Wilkinson J.D., Simard E.P., Liu Y., Phillips M.R., Lloyd B.K., Lo L., Logroscino G., Lunevicius R., Magdy M., Magis-Rodriguez C., Mahdavi M., Malta D.C., Meaney P.A., Margolis D.J., Martinez-Raga J., Mason-Jones A.J., Tedla B.A., Memiah P., Memish Z.A., Mendoza W., Mensink G.B.M., Meretoja T.J., Mhimbira F.A., Miller T.R., Mills E.J., Mohammadi A., Monasta L., Montico M., Ronfani L., Monis J.D., Morawska L., Sun J., Mori R., Werdecker A., Mueller U.O., Westerman R., Murdoch M.E., Murimira B., Murray J., Musa K.I., Nachega J.B., Seedat S., Tran B.X., Nagel G., Rothenbacher D., Naidoo K.S., Oladimeji O., Sartorius B., Zegeye E.A., Naldi L., Remuzzi G., Nangia V., Nejjari C., Newton C.R., Ngalesoni F.N., Nguyen Q.L., Nkamedjie P.M., Nolte S., Osborne R.H., Nomura M., Norheim O.F., Obermeyer C.M., Ogbo F.A., Oh I., Olivares P.R., Olusanya B.O., Olusanya J.O., Opio J.N., Oren E., Ortiz A., Ota E., Mahesh P.A., Park E., Park H., Patel T., Patil S.T., Patten S.B., Tonelli M., Paudel D., Pereira D.M., Perico N., Pesudovs K., Petzold M., Pillay J.D., Polinder S., Qorbani M., Radfar A., Rahman M., Rahman S.U., Rai R.K., Rajsic S., Raju M., Rana S.M., Ranabhat C.L., Ranganathan K., Refaat A.H., Ribeiro A.L., Rojas-Rueda D., Roy A., Sagar R., Satpathy M., Sackey B.B., Saleh M.M., Sanabria J.R., Sarmiento-Suarez R., Savic M., Sawhney M., Schmidhuber J., Schneider I.J.C., Silva D.A.S., Schutte A.E., Shaheen A., Shaikh M.A., and Sharma R.
- Abstract
Background In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015). Methods We applied statistical methods to systematically compiled data to estimate the performance of 33 health-related SDG indicators for 188 countries from 1990 to 2015. We rescaled each indicator on a scale from 0 (worst observed value between 1990 and 2015) to 100 (best observed). Indices representing all 33 health-related SDG indicators (health-related SDG index), health-related SDG indicators included in the Millennium Development Goals (MDG index), and health-related indicators not included in the MDGs (non-MDG index) were computed as the geometric mean of the rescaled indicators by SDG target. We used spline regressions to examine the relations between the Socio-demographic Index (SDI, a summary measure based on average income per person, educational attainment, and total fertility rate) and each of the health-related SDG indicators and indices. Findings In 2015, the median health-related SDG index was 59.3 (95% uncertainty interval 56.8-61.8) and varied widely by country, ranging from 85.5 (84.2-86.5) in Iceland to 20.4 (15.4-24.9) in Central African Republic. SDI was a good predictor of the health-related SDG index (r2=0.88) and the MDG index (r2=0.92), whereas the non-MDG index had a weaker relation with SDI (r2=0.79). Between 2000 and 2015, the health-related SDG index improved by a median of 7.9 (IQR 5.0-10.4), and gains on the MDG index (a median change of 10.0 [6.7-13.1]) exceeded that of the non-MDG index (a median change of 5.5 [2.1-8.9]). Since 2000, pronounced progress occurred for indicators such as met need with modern contraception, under-5 mortality, and neonatal mortality, as well as the indicator for
- Published
- 2016
27. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
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Vos, T., Allen, C., Arora, M., Barber, R., Bhutta, Z., Brown, A., Carter, A., Casey, D., Charlson, F., Chen, A., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Dilegge, T., Erskine, H., Ferrari, A., Fitzmaurice, C., Fleming, T., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kassebaum, N., Kawashima, T., Kemmer, L., Khalil, I., Kinfu, Y., Kyu, H., Leung, J., Liang, X., Lim, S., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Naghavi, M., Nguyen, G., Nsoesie, E., Olsen, H., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., Wagner, J., Wang, H., Wanga, V., Whiteford, H., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Ackerman, I., Adebiyi, A., Ademi, Z., Adou, A., Afanvi, K., Agardh, E., Agarwal, A., Kiadaliri, A., Ahmadieh, H., Ajala, O., Akinyemi, R., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Alegretti, M., Alemu, Z., Alexander, L., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Alvis-Guzman, N., Amare, A., Amberbir, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, G., Anderson, B., Antonio, C., Aregay, A., Arnlov, J., Al, A., Asayesh, H., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, A., Bazargan-Hejazi, S., Bell, B., Bell, M., Bennett, D., Bensenor, I., Benzian, H., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhatt, S., Biadgilign, S., Bienhofff, K., Bikbov, B., Biryukov, S., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Brainin, M., Brazinova, A., Breitborde, N., Brown, J., Buchbinder, R., Buckle, G., Butt, Z., Calabria, B., Ricardo Campos-Nonato, I., Cesar Campuzano, J., Carabin, H., Cardenas, R., Carpenter, D., Carrero, J., Castaneda-Orjuela, C., Castillo Rivas, J., Catala-Lopez, F., Chang, J., Chiang, P., Chibueze, C., Chisumpa, V., Choi, J., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Coates, M., Colquhoun, S., Cooper, C., Cortinovis, M., Crump, J., Damtew, S., Dandona, R., Daoud, F., Dargan, P., das Neves, J., Davey, G., Davis, A., De Leo, D., Degenhardt, L., Del Gobbo, L., Dellavalle, R., Deribe, K., Deribew, A., Derrett, S., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Torne, C., Ding, E., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Ebrahimi, H., Ellenbogen, R., Elyazar, I., Endres, M., Endries, A., Ermakov, S., Eshrati, B., Estep, K., Farid, T., Sofia e Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Felson, D., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foreman, K., Fowkes, G., Fox, J., Franklin, R., Friedman, J., Frostad, J., Furst, T., Futran, N., Gabbe, B., Ganguly, P., Gankpe, F., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Gibney, K., Ginawi, I., Giref, A., Giroud, M., Gishu, M., Glaser, E., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Grainger, R., Greaves, F., Guillemin, F., Guo, Y., Gupta, R., Gupta, V., Gutierrez, R., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Hammami, M., Hancock, J., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Havmoeller, R., Hay, R., Beatriz Heredia-Pi, I., Heydarpour, P., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Htet, A., Huang, H., Huang, J., Huynh, C., Iannarone, M., Iburg, K., Innos, K., Inoue, M., Iyer, V., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jensen, P., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jin, Y., Jonas, J., Kabir, Z., 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Woodbrook, R., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yan, L., Yano, Y., Yaseri, M., Ye, P., Yebyo, H., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zeeb, H., Zhou, M., Zodpey, S., Zuhlke, L., and Murray, C.
- Abstract
© 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licenseBackground Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60?900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9·3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year.
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- 2016
28. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
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Kassebaum, N., Arora, M., Barber, R., Bhutta, Z., Carter, A., Casey, D., Charlson, F., Coates, M., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Erskine, H., Ferrari, A., Fitzmaurice, C., Foreman, K., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kemmer, L., Khalil, I., Kinfu, Y., Kutz, M., Kyu, H., Leung, J., Liang, X., Lim, S., Lozano, R., Mensah, G., Mikesell, J., Mokdad, A., Mooney, M., Naghavi, M., Nguyen, G., Nsoesie, E., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Sorensen, R., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., VanderZanden, A., Wagner, J., Wanga, V., Whiteford, H., Zhou, M., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Achoki, T., Ackerman, I., Adebiyi, A., Adedeji, I., Adsuar, J., Afanvi, K., Afshin, A., Agardh, E., Agarwal, A., Kumar, S., Ahmed, M., Kiadaliri, 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Sanchez-Nino, M., Santos, I., Santos, J., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidt, M., Schneider, I., Schutte, A., Schwebel, D., Seedat, S., Sepanlou, S., Servan-Mori, E., Shahraz, S., Shaikh, M., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shibuya, K., Shigematsu, M., Shin, M., Shin, R., Sigfusdottir, I., Santos Silva, D., Silverberg, J., Simard, E., Singh, A., Singh, J., Singh, P., Skirbekk, V., Skogen, J., Soljak, M., Soreide, K., Sreeramareddy, C., Stathopoulou, V., Steel, N., Stein, D., Stein, M., Steiner, T., Stovner, L., Stranges, S., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Ao, B., Tegegne, T., Tekle, D., Terkawi, A., Tessema, G., Thakur, J., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Topouzis, F., Tran, B., Dimbuene, Z., Tsilimbaris, M., 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- Published
- 2016
29. NER19: Clinical, serological, and radiological presentations of neurocysticercosis among people with and without HIV in southern highlands of Tanzania.
- Author
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Makasi, Charles, Ngowi, B. J., Mahande, B. J., Stelzle, D., Mfinanga, G. S., Kilale, A. M., Carabin, H., Winkler, A., and Mmbaga, B. T.
- Abstract
Background: Neurocysticercosis (NCC) is a form of cysticercosis which affects the central nervous. Human immunodeficiency virus (HIV) may affect the clinical and radiological presentation of NCC in people living with HIV (PLWHIV), but this has not been studied in our society. Objectives: To describe the clinical, serological, and radiological characteristics of PLWHIV and NCC recruited through HIV clinics compared to non-HIV controls from the community in southern highlands of Tanzania Methods: Paired cross-sectional study was done (April 2018 to April 2021) whereby PLWHIV from Health facilities were paired with HIV negative individuals from communities of Chunya and Iringa districts. Pairs were matched by sex, age, and distance living within 100M of PLHIV residence. Serological test was done for cysticercosis. If either index or control turned serologically positive for cysticercosis, the pair qualified for detailed clinical neurological assessment and CT scan examination. Data analysis was done by using Stata version 15. A descriptive analysis was performed before building a conditional logistic regression model for prediction of the associations between each potential independent predictor (including HIV) and the dependent variable neuro/cysticercosis. A P-value of < 0.05 was regarded as statistically significant. Results: Total of 2,564 participants were analyzed; 1,415 (55.2%) being female. Mean (SD) age was 43 (11.4) years. T. Solium cysticercosis serology was done for 2,407 samples and 87 (3.4%) were positive with 52 (4.1%) PLWHIV and 35 (2.7%) without HIV (P<0.04). Of the 164 who went for CT scan; 109 (66.5%) came from Tosamaganga and 106 (64.6%) of all were male); 31 (18.2%) had NCC {17 (54.8%) calcified lesions and 14 (45.2%) active lesions}. Neurocysticercosis manifested with chronic headache and seizures. The number, stage and locations of cysts were not statistically different between HIV negative individuals and PLWHIV. Conclusions: NCC is more prevalent in PLWHIV, and mixed lesions were more common. [ABSTRACT FROM AUTHOR]
- Published
- 2022
30. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
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Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abdulkader, Rizwan Suliankatchi, Abdulle, Abdishakur M, Abebo, Teshome Abuka, Abera, Semaw Ferede, Aboyans, Victor, Abu-Raddad, Laith J, Ackerman, Ilana N, Adedeji, Isaac A, Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Sutapa, Agrawal, Anurag, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibtihel, Aiyar, Sneha, Akinyemiju, Tomi F, Akseer, Nadia, Al Lami, Faris Hasan, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alasfoor, Deena, Alene, Kefyalew Addis, Ali, Raghib, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Maskari, Fatma, AlMazroa, Mohammad AbdulAziz, Al-Raddadi, Rajaa, Alsharif, Ubai, Alsowaidi, Shirina, Althouse, Benjamin M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asgedom, Solomon W, Atey, Tesfay Mehari, Atnafu, Niguse Tadele, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Awasthi, Shally, Azarpazhooh, Mahmoud Reza, Azzopardi, Peter, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Bannick, Marlena S, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barquera, Simon, Barrero, Lope H, Basu, Sanjay, Battista, Robert, Battle, Katherine E, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Beyene, Addisu Shunu, Bhansali, Anil, Bhatt, Samir, Bhutta, Zulfiqar A, Biadgilign, Sibhatu, Bicer, Burcu Kucuk, Bienhoff, Kelly, Bikbov, Boris, Birungi, Charles, Biryukov, Stan, Bisanzio, Donal, Bizuayehu, Habtamu Mellie, Blyth, Fiona M, Boneya, Dube Jara, Bose, Dipan, Bou-Orm, Ibrahim R, Bourne, Rupert R A, Brainin, Michael, Brayne, Carol, Brazinova, Alexandra, Breitborde, Nicholas J K, Briant, Paul S, Britton, Gabrielle, Brugha, Traolach S, Buchbinder, Rachelle, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campos-Nonato, Ismael Ricardo, Carabin, Hélène, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesus, Carter, Austin, Carvalho, Felix, Casey, Daniel, Castañeda-Orjuela, Carlos A, Castle, Chris D, Catalá-López, Ferrán, Chang, Jung-Chen, Charlson, Fiona J, Chaturvedi, Pankaj, Chen, Honglei, Chibalabala, Mirriam, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Chowdhury, Rajiv, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cirillo, Massimo, Colombara, Danny, Cooper, Leslie Trumbull, Cooper, 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Uthman, O, Uzochukwu, B, van Boven, J, Varughese, S, Vasankari, T, Veerman, L, Venkatesh, S, Venketasubramanian, N, Vidavalur, R, Vijayakumar, L, Violante, F, Vishnu, A, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Wadilo, F, Wakayo, T, Wallin, M, Wang, Y, Weichenthal, S, Weiderpass, E, Weintraub, R, Weiss, D, Werdecker, A, Westerman, R, Whiteford, H, Wijeratne, T, Williams, H, Wiysonge, C, Woldeyes, B, Wolfe, C, Woodbrook, R, Woolf, A, Workicho, A, Xavier, D, Xu, G, Yadgir, S, Yaghoubi, M, Yakob, B, Yan, L, Yano, Y, Ye, P, Yihdego, M, Yimam, H, Yip, P, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Yu, C, Zaidi, Z, Zaki, M, Zegeye, E, Zenebe, Z, Zhang, X, Zheng, Y, Zhou, M, Zipkin, B, Zodpey, S, Zoeckler, L, Zuhlke, L, Brayne, Carol [0000-0001-5307-663X], Chowdhury, Rajiv [0000-0003-4881-5690], and Apollo - University of Cambridge Repository
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Male ,Dánarmein ,AUSTRALIA ,GBD, disability-adjusted life-years (DALYs) ,Heilsufar ,Lífslíkur ,Epidemiology ,Life expectancy ,Diseases ,Global Health ,THERAPY ,Global Burden of Disease ,Residence Characteristics ,Fullorðnir ,Cause of Death ,Medicine and Health Sciences ,Psychology ,Konur ,Aged, 80 and over ,Tölfræði ,PLASMODIUM-FALCIPARUM ,Aldraðir ,Sjúkdómar ,Medicine (all) ,Fatlaðir ,Men ,Þjóðir ,11 Medical And Health Sciences ,ASSOCIATION ,Middle Aged ,Health policy ,PREVALENCE ,Sálfræði ,disability-adjusted life-years (DALYs) ,Female ,Lýðheilsa ,Quality-Adjusted Life Years ,Life Sciences & Biomedicine ,Global Health Metrics ,Adult ,AFRICA ,Quality of life ,People with disabilities ,GBD ,WEIGHTS ,Social ecology ,Lífsgæði ,Communicable Diseases ,World health/statistics ,Age Distribution ,Life Expectancy ,Medicine, General & Internal ,SDG 3 - Good Health and Well-being ,General & Internal Medicine ,Heilbrigðisstefna ,Humans ,Adults ,Disabled Persons ,Women ,Sex Distribution ,Mortality ,Noncommunicable Diseases ,Aged ,Science & Technology ,Faraldsfræði ,MORTALITY ,Wounds and injuries ,EPIDEMIOLOGIC TRANSITION ,HIV ,Áverkar ,Karlar ,Wounds and Injuries ,Félagshagfræði ,Older people - Abstract
Correction in: LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings The highest globally observed HALE at birth for both women and men was in Singapore, at 75.2 years (95% uncertainty interval 71.9-78.6) for females and 72.0 years (68.8-75.1) for males. The lowest for females was in the Central African Republic (45.6 years [42.0-49.5]) and for males was in Lesotho (41.5 years [39.0-44.0]). From 1990 to 2016, global HALE increased by an average of 6.24 years (5.97-6.48) for both sexes combined. Global HALE increased by 6.04 years (5.74-6.27) for males and 6.49 years (6.08-6.77) for females, whereas HALE at age 65 years increased by 1.78 years (1.61-1.93) for males and 1.96 years (1.69-2.13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2.3% [-5.9 to 0.9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16.1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. Interpretation At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support., Bill & Melinda Gates Foundation
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31. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries : an analysis from the Global Burden of Disease Study 2016
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Adult ,Male ,Adolescent ,DEVELOPMENT ASSISTANCE ,Global Health ,projection indicators to 2030 ,CHINA ,Global Burden of Disease ,Health Statu ,MEXICO ,Noncommunicable Disease ,Young Adult ,SYSTEMS ,Quality-Adjusted Life Year ,General & Internal Medicine ,Infant Mortality ,Medicine and Health Sciences ,Conservation of Natural Resource ,gains and gaps for the health-related SDGs,annualized rates of change, projection indicators to 2030 ,Health Status Indicator ,annualized rates of change ,Child ,Medicine (all) ,MORTALITY ,Infant, Newborn ,Infant ,Child Abuse, Sexual ,Middle Aged ,PREPAID PRIVATE ,CARE ,COVERAGE ,Sex Offense ,Child, Preschool ,Female ,40-PERCENT ,GOVERNMENT ,gains and gaps for the health-related SDGs ,Human - Abstract
Background The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030. Methods We used standardised GBD 2016 methods to measure 37 health-related indicators from 1990 to 2016, an increase of four indicators since GBD 2015. We substantially revised the universal health coverage (UHC) measure, which focuses on coverage of essential health services, to also represent personal health-care access and quality for several non-communicable diseases. We transformed each indicator on a scale of 0-100, with 0 as the 2.5th percentile estimated between 1990 and 2030, and 100 as the 97.5th percentile during that time. An index representing all 37 health-related SDG indicators was constructed by taking the geometric mean of scaled indicators by target. On the basis of past trends, we produced projections of indicator values, using a weighted average of the indicator and country-specific annualised rates of change from 1990 to 2016 with weights for each annual rate of change based on out-of-sample validity. 24 of the currently measured health-related SDG indicators have defined SDG targets, against which we assessed attainment. Findings Globally, the median health-related SDG index was 56.7 (IQR 31.9-66.8) in 2016 and country-level performance markedly varied, with Singapore (86.8, 95% uncertainty interval 84.6-88.9), Iceland (86.0, 84.1-87.6), and Sweden (85.6, 81.8-87.8) having the highest levels in 2016 and Afghanistan (10.9, 9.6-11.9), the Central African Republic (11.0, 8.8-13.8), and Somalia (11.3, 9.5-13.1) recording the lowest. Between 2000 and 2016, notable improvements in the UHC index were achieved by several countries, including Cambodia, Rwanda, Equatorial Guinea, Laos, Turkey, and China; however, a number of countries, such as Lesotho and the Central African Republic, but also high-income countries, such as the USA, showed minimal gains. Based on projections of past trends, the median number of SDG targets attained in 2030 was five (IQR 2-8) of the 24 defined targets currently measured. Globally, projected target attainment considerably varied by SDG indicator, ranging from more than 60% of countries projected to reach targets for under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria, to less than 5% of countries projected to achieve targets linked to 11 indicator targets, including those for childhood overweight, tuberculosis, and road injury mortality. For several of the health-related SDGs, meeting defined targets hinges upon substantially faster progress than what most countries have achieved in the past. Interpretation GBD 2016 provides an updated and expanded evidence base on where the world currently stands in terms of the health-related SDGs. Our improved measure of UHC offers a basis to monitor the expansion of health services necessary to meet the SDGs. Based on past rates of progress, many places are facing challenges in meeting defined health-related SDG targets, particularly among countries that are the worst off. In view of the early stages of SDG implementation, however, opportunity remains to take actions to accelerate progress, as shown by the catalytic effects of adopting the Millennium Development Goals after 2000. With the SDGs' broader, bolder development agenda, multisectoral commitments and investments are vital to make the health-related SDGs within reach of all populations. Copyright The Authors. Published by Elsevier Ltd. This is an Open Access article published under the CC BY 4.0 license.
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32. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
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Silveira, Dayane Gabriele Alves, Singh, Abhishek, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Sliwa, Karen, Soljak, Michael, Søreide, Kjetil, Sorensen, Reed J D, Soriano, Joan B, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Timothy J, Steinke, Sabine, Stovner, Lars, Stroumpoulis, Konstantinos, Sunguya, Bruno F, Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Takala, Jukka S, Tandon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R, Ao, Braden J Te, Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Truelsen, Thomas, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Uthman, Olalekan A, van Gool, Coen H, Varakin, Yuri Y, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wang, Linhong, Watkins, David A, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Westerman, Ronny, White, Richard A, Williams, Hywel C, Wiysonge, Charles Shey, Wolfe, Charles D A, Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Murray, Christopher J L, Vos, T, Allen, C, Arora, M, Barber, Rm, Bhutta, Za, Brown, A, Carter, A, Casey, Dc, Charlson, Fj, Chen, Az, Coggeshall, M, Cornaby, L, Dandona, L, Dicker, Dj, Dilegge, T, Erskine, He, Ferrari, Aj, Fitzmaurice, C, Fleming, T, Forouzanfar, Mh, Fullman, N, Gething, Pw, Goldberg, Em, Graetz, N, Haagsma, Ja, Johnson, Co, Kassebaum, Nj, Kawashima, T, Kemmer, L, Khalil, Ia, Kinfu, Y, Kyu, Hh, Leung, J, Liang, X, Lim, S, Lopez, Ad, Lozano, R, Marczak, L, Mensah, Ga, Mokdad, Ah, Naghavi, M, Nguyen, G, Nsoesie, E, Olsen, H, Pigott, Dm, Pinho, C, Rankin, Z, Reinig, N, Salomon, Ja, Sandar, L, Smith, A, Stanaway, J, Steiner, C, Teeple, S, Thomas, Ba, Troeger, C, Wagner, Ja, Wang, H, Wanga, V, Whiteford, Ha, Zoeckler, L, Abajobir, Aa, Abate, Kh, Abbafati, C, Abbas, Km, Abd Allah, F, Abraham, B, Abubakar, I, Abu Raddad, Lj, Abu Rmeileh, Nm, Ackerman, In, Adebiyi, Ao, Ademi, Z, Adou, Ak, Afanvi, Ka, Agardh, Ee, Agarwal, A, Kiadaliri, Aa, Ahmadieh, H, Ajala, On, Akinyemi, Ro, Akseer, N, Al Aly, Z, Alam, K, Alam, Nk, Aldhahri, Sf, Alegretti, Ma, Alemu, Za, Alexander, Lt, Alhabib, S, Ali, R, Alkerwi, A, Alla, F, Allebeck, P, Al Raddadi, R, Alsharif, U, Altirkawi, Ka, Alvis Guzman, N, Amare, At, Amberbir, A, Amini, H, Ammar, W, Amrock, Sm, Andersen, Hh, Anderson, Gm, Anderson, Bo, Antonio, Ca, Aregay, Af, Ärnlöv, J, Artaman, A, Asayesh, H, Assadi, R, Atique, S, Avokpaho, Ef, Awasthi, A, Quintanilla, Bp, Azzopardi, P, Bacha, U, Badawi, A, Balakrishnan, K, Banerjee, A, Barac, A, Barker Collo, Sl, Bärnighausen, T, Barregard, L, Barrero, Lh, Basu, A, Bazargan Hejazi, S, Bell, B, Bell, Ml, Bennett, Da, Bensenor, Im, Benzian, H, Berhane, A, Bernabé, E, Betsu, Bd, Beyene, A, Bhala, N, Bhatt, S, Biadgilign, S, Bienhoff, K, Bikbov, B, Biryukov, S, Bisanzio, D, Bjertness, E, Blore, J, Borschmann, R, Boufous, S, Brainin, M, Brazinova, A, Breitborde, Nj, Brown, J, Buchbinder, R, Buckle, Gc, Butt, Za, Calabria, B, Campos Nonato, Ir, Campuzano, Jc, Carabin, H, Cárdenas, R, Carpenter, Do, Carrero, Jj, Castañeda Orjuela, Ca, Rivas, Jc, Catalá López, F, Chang, Jc, Chiang, Pp, Chibueze, Ce, Chisumpa, Vh, Choi, Jj, Chowdhury, R, Christensen, H, Christopher, Dj, Ciobanu, Lg, Cirillo, Massimo, Coates, Mm, Colquhoun, Sm, Cooper, C, Cortinovis, M, Crump, Ja, Gastroenterology & Hepatology, Health Services Management & Organisation (HSMO), Public Health, Psychiatry, Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M, Bhutta, Zulfiqar A, Brown, Alexandria, Carter, Austin, Casey, Daniel C, Charlson, Fiona J, Chen, Alan Z, Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J, Dilegge, Tina, Erskine, Holly E, Ferrari, Alize J, Fitzmaurice, Christina, Fleming, Tom, Forouzanfar, Mohammad H, Fullman, Nancy, Gething, Peter W, Goldberg, Ellen M, Graetz, Nichola, Haagsma, Juanita A, Johnson, Catherine O, Kassebaum, Nicholas J, Kawashima, Toana, Kemmer, Laura, Khalil, Ibrahim A, Kinfu, Yohanne, Kyu, Hmwe H, Leung, Janni, Liang, Xiaofeng, Lim, Stephen S, Lopez, Alan D, Lozano, Rafael, Marczak, Laurie, Mensah, George A, Mokdad, Ali H, Naghavi, Mohsen, Nguyen, Grant, Nsoesie, Elaine, Olsen, Helen, Pigott, David M, Pinho, Christine, Rankin, Zane, Reinig, Nikola, Salomon, Joshua A, Sandar, Logan, Smith, Alison, Stanaway, Jeffrey, Steiner, Caitlyn, Teeple, Stephanie, Thomas, Bernadette A, Troeger, Christopher, Wagner, Joseph A, Wang, Haidong, Wanga, Valentine, Whiteford, Harvey A, Zoeckler, Leo, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Ackerman, Ilana N, Adebiyi, Akindele Olupelumi, Ademi, Zanfina, Adou, Arsène Kouablan, Afanvi, Kossivi Agbelenko, Agardh, Emilie Elisabet, Agarwal, Arnav, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ajala, Oluremi N, Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K M, Aldhahri, Saleh Fahed, Alegretti, Miguel Angel, Alemu, Zewdie Aderaw, Alexander, Lily T, Alhabib, Samia, Ali, Raghib, Alkerwi, Ala'A, Alla, Françoi, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H, Anderson, Gregory M, Anderson, Benjamin O, Antonio, Carl Abelardo T, Aregay, Atsede Fantahun, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barregard, Lar, Barrero, Lope H, Basu, Arindam, Bazargan-Hejazi, Shahrzad, Bell, Brent, Bell, Michelle L, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Bori, Biryukov, Stan, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Borschmann, Rohan, Boufous, Soufiane, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brown, Jonathan, Buchbinder, Rachelle, Buckle, Geoffrey Colin, Butt, Zahid A, Calabria, Bianca, Campos-Nonato, Ismael Ricardo, Campuzano, Julio Cesar, Carabin, Hélène, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesu, Castañeda-Orjuela, Carlos A, Rivas, Jacqueline Castillo, Catalá-López, Ferrán, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam Jesuda, Ciobanu, Liliana G, Coates, Matthew M, Colquhoun, Samantha M, Cooper, Cyru, Cortinovis, Monica, Crump, John A, Damtew, Solomon Abrha, Dandona, Rakhi, Daoud, Farah, Dargan, Paul I, das Neves, José, Davey, Gail, Davis, Adrian C, Leo, Diego De, Degenhardt, Louisa, Gobbo, Liana C Del, Dellavalle, Robert P, Deribe, Kebede, Deribew, Amare, Derrett, Sarah, Jarlais, Don C De, Dharmaratne, Samath D, Dhillon, Preet K, Diaz-Torné, Cesar, Ding, Eric L, Driscoll, Tim R, Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Ebrahimi, Hedyeh, Ellenbogen, Richard G, Elyazar, Iqbal, Endres, Matthia, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Estep, Kara, Farid, Talha A, Farinha, Carla Sofia e Sa, Faro, André, Farvid, Maryam S, Farzadfar, Farshad, Feigin, Valery L, Felson, David T, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Fernandes, Joao C, Fischer, Florian, Fitchett, Joseph R A, Foreman, Kyle, Fowkes, F Gerry R, Fox, Jordan, Franklin, Richard C, Friedman, Joseph, Frostad, Joseph, Fürst, Thoma, Futran, Neal D, Gabbe, Belinda, Ganguly, Parthasarathi, Gankpé, Fortuné Gbètoho, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M, Gessner, Bradford D, Gibney, Katherine B, Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Godwin, William W, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Grainger, Rebecca, Greaves, Felix, Guillemin, Franci, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutiérrez, Reyna A, Haile, Demewoz, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Halasa, Yara A, Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Havmoeller, Rasmu, Hay, Roderick J, Heredia-Pi, Ileana Beatriz, Heydarpour, Pouria, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hoy, Damian G, Htet, Aung Soe, Huang, Hsiang, Huang, John J, Huynh, Chantal, Iannarone, Marissa, Iburg, Kim Moesgaard, Innos, Kaire, Inoue, Manami, Iyer, Veena J, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N, Jiang, Ying, Jibat, Tariku, Jimenez-Corona, Aida, Jin, Ye, Jonas, Jost B, Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A, Kosen, Soewarta, Kotsakis, Georgios A, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A, Kuipers, Ernst J, Kumar, G Anil, Kutz, Michael, Kwan, Gene F, Lal, Aparna, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lam, Jennifer O, Langan, Sinead M, Larsson, Ander, Lavados, Pablo M, Leasher, Janet L, Leigh, Jame, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lo, Warren D, Logroscino, Giancarlo, Looker, Katharine J, Lotufo, Paulo A, Lunevicius, Raimunda, Lyons, Ronan A, Mackay, Mark T, Magdy, Mohammed, Razek, Abd El, Mahdavi, Mahdi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David Joel, Martinez-Raga, Jose, Masiye, Felix, Massano, João, Mcgarvey, Stephen Theodore, Mcgrath, John J, Mckee, Martin, Mcmahon, Brian J, Meaney, Peter A, Mehari, Alem, Mejia-Rodriguez, Fabiola, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J, Mhimbira, Francis Apolinary, Miller, Ted R, Mills, Edward J, Mirarefin, Mojde, Mitchell, Philip B, Mock, Charles N, Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Hernandez, Julio Cesar Montañez, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Morawska, Lidia, Mueller, Ulrich O, Mullany, Erin, Mumford, John Everett, Murdoch, Michele E, Nachega, Jean B, Nagel, Gabriele, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Newton, John N, Ng, Marie, Ngalesoni, Frida Namnyak, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Nolla, Joan M, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nunes, Bruno P, Ogbo, Felix Akpojene, Oh, In-Hwan, Ohkubo, Takayoshi, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Pa, Mahesh, Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valéria Maria, Caicedo, Angel J Paternina, Patten, Scott B, Patton, George C, Pereira, David M, Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B, Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A, Polinder, Suzanne, Pond, Constance D, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Qorbani, Mostafa, Rabiee, Rynaz H S, Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rao, Puja, Refaat, Amany H, Reitsma, Marissa B, Remuzzi, Giuseppe, Resnikoff, Serge, Reynolds, Alex, Ribeiro, Antonio L, Blancas, Maria Jesus Rio, Roba, Hirbo Shore, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Roy, Ambuj, Sagar, Rajesh, Sahathevan, Ramesh, Sanabria, Juan R, Sanchez-Niño, Maria Dolore, Santos, Itamar S, Santos, João Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schaub, Michael P, Schmidt, Maria Inê, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya A, Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S, Sheth, Kevin N, Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga Dora, Silva, Diego Augusto Santo, Silveira, Dayane Gabriele Alve, Singh, Abhishek, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Sliwa, Karen, Soljak, Michael, Søreide, Kjetil, Soriano, Joan B, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Steel, Nichola, Stein, Dan J, Steiner, Timothy J, Steinke, Sabine, Stovner, Lar, Stroumpoulis, Konstantino, Sunguya, Bruno F, Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Takala, Jukka S, Tandon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R, Ao, Braden J Te, Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadi, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefano, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Uthman, Olalekan A, van Gool, Coen H, Varakin, Yuri Y, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wang, Linhong, Watkins, David A, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Westerman, Ronny, White, Richard A, Williams, Hywel C, Wiysonge, Charles Shey, Wolfe, Charles D A, Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Deni, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, and Murray, Christopher J L
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Medicine(all) ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,Incidence ,Medicine (all) ,Public Health, Global Health, Social Medicine and Epidemiology ,Bayes Theorem ,11 Medical And Health Sciences ,Articles ,Department of Error ,Global Health ,Cost of Illne ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Cost of Illness ,disability ,General & Internal Medicine ,Quality-Adjusted Life Year ,Prevalence ,Humans ,Disabled Person ,Disabled Persons ,Quality-Adjusted Life Years ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,Human - Abstract
Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60 900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9·3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year. In 2015, two causes had acute incidences in excess of 1 billion: upper respiratory infections (17·2 billion, 95% uncertainty interval [UI] 15·4–19·2 billion) and diarrhoeal diseases (2·39 billion, 2·30–2·50 billion). Eight causes of chronic disease and injury each affected more than 10% of the world's population in 2015: permanent caries, tension-type headache, iron-deficiency anaemia, age-related and other hearing loss, migraine, genital herpes, refraction and accommodation disorders, and ascariasis. The impairment that affected the greatest number of people in 2015 was anaemia, with 2·36 billion (2·35–2·37 billion) individuals affected. The second and third leading impairments by number of individuals affected were hearing loss and vision loss, respectively. Between 2005 and 2015, there was little change in the leading causes of years lived with disability (YLDs) on a global basis. NCDs accounted for 18 of the leading 20 causes of age-standardised YLDs on a global scale. Where rates were decreasing, the rate of decrease for YLDs was slower than that of years of life lost (YLLs) for nearly every cause included in our analysis. For low SDI geographies, Group 1 causes typically accounted for 20–30% of total disability, largely attributable to nutritional deficiencies, malaria, neglected tropical diseases, HIV/AIDS, and tuberculosis. Lower back and neck pain was the leading global cause of disability in 2015 in most countries. The leading cause was sense organ disorders in 22 countries in Asia and Africa and one in central Latin America; diabetes in four countries in Oceania; HIV/AIDS in three southern sub-Saharan African countries; collective violence and legal intervention in two north African and Middle Eastern countries; iron-deficiency anaemia in Somalia and Venezuela; depression in Uganda; onchoceriasis in Liberia; and other neglected tropical diseases in the Democratic Republic of the Congo. Interpretation Ageing of the world's population is increasing the number of people living with sequelae of diseases and injuries. Shifts in the epidemiological profile driven by socioeconomic change also contribute to the continued increase in years lived with disability (YLDs) as well as the rate of increase in YLDs. Despite limitations imposed by gaps in data availability and the variable quality of the data available, the standardised and comprehensive approach of the GBD study provides opportunities to examine broad trends, compare those trends between countries or subnational geographies, benchmark against locations at similar stages of development, and gauge the strength or weakness of the estimates available. Funding Bill & Melinda Gates Foundation. Open Access funded by Bill & Melinda Gates FoundationUnder a Creative Commons license Attribution 4.0 International (CC BY 4.0)
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- 2016
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33. Sensitivity and specificity of International Classification of Diseases algorithms (ICD-9 and ICD-10) used to identify opioid-related overdose cases: A systematic review and an example of estimation using Bayesian latent class models in the absence of gold standards.
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Mbutiwi FIN, Yapo APJ, Toirambe SE, Rees E, Plouffe R, and Carabin H
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- Humans, Latent Class Analysis, International Classification of Diseases, Bayes Theorem, Algorithms, Sensitivity and Specificity, Opiate Overdose
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Objectives: This study aimed to summarize validity estimates of International Classification of Diseases (ICD) codes in identifying opioid overdose (OOD) among patient data from emergency rooms, emergency medical services, inpatient, outpatient, administrative, medical claims, and mortality, and estimate the sensitivity and specificity of the algorithms in the absence of a perfect reference standard., Methods: We systematically reviewed studies published before December 8, 2023, and identified with Medline and Embase. Studies reporting sufficient details to recreate a 2 × 2 table comparing the ICD algorithms to a reference standard in diagnosing OOD-related events were included. We used Bayesian latent class models (BLCM) to estimate the posterior sensitivity and specificity distributions of five ICD-10 algorithms and of the imperfect coroner's report review (CRR) in detecting prescription opioid-related deaths (POD) using one included study., Results: Of a total of 1990 studies reviewed, three were included. The reported sensitivity estimates of ICD algorithms for OOD were low (range from 25.0% to 56.8%) for ICD-9 in diagnosing non-fatal OOD-related events and moderate (72% to 89%) for ICD-10 in diagnosing POD. The last included study used ICD-9 for non-fatal and fatal and ICD-10 for fatal OOD-related events and showed high sensitivity (i.e. above 97%). The specificity estimates of ICD algorithms were good to excellent in the three included studies. The misclassification-adjusted ICD-10 algorithm sensitivity estimates for POD from BLCM were consistently higher than reported sensitivity estimates that assumed CRR was perfect., Conclusion: Evidence on the performance of ICD algorithms in detecting OOD events is scarce, and the absence of bias correction for imperfect tests leads to an underestimation of the sensitivity of ICD code estimates., (© 2024. The Author(s).)
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- 2024
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34. Serum Proteomic Predictors of Calcification of Solitary Cysticercus Granuloma.
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Pamela BE, Thamizhmaran S, Jackson E, Vasudevan P, Moorthy RK, Manoj J, Thanigachalam A, Drevets DA, Carabin H, Oommen A, and Rajshekhar V
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- Humans, Female, Male, Adolescent, Child, Cysticercosis blood, Extracellular Matrix Proteins blood, Cysticercus, Adult, Animals, Biomarkers blood, Young Adult, Immediate-Early Proteins blood, Calcinosis blood, Granuloma blood, Proteomics
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Solitary cysticercus granulomas (SCG), prevalent among Indian patients with new-onset seizures, either resolve completely or transform into calcified granulomas. This study aimed to identify serum proteins through liquid chromatography-tandem mass spectrometry that could predict calcification of SCGs in 20 patients with SCG with at least 6-months of follow-up. At a median follow-up of 14 months, the SCG had calcified (n = 5), resolved (n = 11), or persisted (n = 4). Two serum proteins, ECM1 and MST1, were present in significantly higher serum concentrations, and AZGP1 in significantly lower concentration in subjects with calcifying SCGs than in those with lesions that resolved or persisted. On multivariate analysis, only ECM1 (odds ratio: 1.7, 95% CI: 0-2.8) and MST1 (odds ratio: 3.3, 95% CI: 0-4.1) were independent predictors of calcification of SCG. Combining elevated levels of serum ECM1 and MST1 had a sensitivity of 100% and specificity of 100% in differentiating granulomas that calcified from those that resolved/persisted. Increased expression of serum ECM1 and MST1 in patients with SCG might predict calcification.
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- 2024
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35. Linking Opinions Shared on Social Media About COVID-19 Public Health Measures to Adherence: Repeated Cross-Sectional Surveys of Twitter Use in Canada.
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Denis-Robichaud J, Rees EE, Daley P, Zarowsky C, Diouf A, Nasri BR, de Montigny S, and Carabin H
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- Humans, Cross-Sectional Studies, Canada, Adult, Male, Female, Middle Aged, Bayes Theorem, Young Adult, Masks statistics & numerical data, Aged, SARS-CoV-2, Surveys and Questionnaires, Adolescent, Patient Compliance statistics & numerical data, Self Report, Vaccination statistics & numerical data, COVID-19 prevention & control, Social Media statistics & numerical data, Public Health
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Background: The effectiveness of public health measures (PHMs) depends on population adherence. Social media were suggested as a tool to assess adherence, but representativeness and accuracy issues have been raised., Objective: The objectives of this repeated cross-sectional study were to compare self-reported PHM adherence and sociodemographic characteristics between people who used Twitter (subsequently rebranded X) and people who did not use Twitter., Methods: Repeated Canada-wide web-based surveys were conducted every 14 days from September 2020 to March 2022. Weighted proportions were calculated for descriptive variables. Using Bayesian logistic regression models, we investigated associations between Twitter use, as well as opinions in tweets, and self-reported adherence with mask wearing and vaccination., Results: Data from 40,230 respondents were analyzed. As self-reported, Twitter was used by 20.6% (95% CI 20.1%-21.2%) of Canadians, of whom 29.9% (95% CI 28.6%-31.3%) tweeted about COVID-19. The sociodemographic characteristics differed across categories of Twitter use and opinions. Overall, 11% (95% CI 10.6%-11.3%) of Canadians reported poor adherence to mask-wearing, and 10.8% (95% CI 10.4%-11.2%) to vaccination. Twitter users who tweeted about COVID-19 reported poorer adherence to mask wearing than nonusers, which was modified by the age of the respondents and their geographical region (odds ratio [OR] 0.79, 95% Bayesian credibility interval [BCI] 0.18-1.69 to OR 4.83, 95% BCI 3.13-6.86). The odds of poor adherence to vaccination of Twitter users who tweeted about COVID-19 were greater than those of nonusers (OR 1.76, 95% BCI 1.48-2.07). English- and French-speaking Twitter users who tweeted critically of PHMs were more likely (OR 4.07, 95% BCI 3.38-4.80 and OR 7.31, 95% BCI 4.26-11.03, respectively) to report poor adherence to mask wearing than non-Twitter users, and those who tweeted in support were less likely (OR 0.47, 95% BCI 0.31-0.64 and OR 0.96, 95% BCI 0.18-2.33, respectively) to report poor adherence to mask wearing than non-Twitter users. The OR of poor adherence to vaccination for those tweeting critically about PHMs and for those tweeting in support of PHMs were 4.10 (95% BCI 3.40-4.85) and 0.20 (95% BCI 0.10-0.32), respectively, compared to non-Twitter users., Conclusions: Opinions shared on Twitter can be useful to public health authorities, as they are associated with adherence to PHMs. However, the sociodemographics of social media users do not represent the general population, calling for caution when using tweets to assess general population-level behaviors., (©José Denis-Robichaud, Erin E Rees, Patrick Daley, Christina Zarowsky, Assane Diouf, Bouchra R Nasri, Simon de Montigny, Hélène Carabin. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 13.08.2024.)
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- 2024
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36. Evaluating the modulation of peripheral immune profile in people living with HIV and (Neuro)cysticercosis.
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Lema YL, Prodjinotho UF, Makasi C, Nanyaro MA, Kilale AM, Mfinanga S, Stelzle D, Schmidt V, Carabin H, Winkler AS, Lyamuya EF, Ngowi BJ, Chachage M, and Prazeres da Costa C
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- Humans, Male, Adult, Female, Cross-Sectional Studies, Middle Aged, Tanzania epidemiology, Antibodies, Helminth blood, Animals, CD4 Lymphocyte Count, Young Adult, Antigens, Helminth immunology, Antigens, Helminth blood, Neurocysticercosis immunology, Neurocysticercosis complications, HIV Infections complications, HIV Infections immunology, Cytokines blood, Coinfection immunology, Taenia solium immunology
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Background: The parasitic infection caused by Taenia solium represents a significant public health concern in developing countries. Larval invasion of body tissues leads to cysticercosis (CC), while central nervous system (CNS) involvement results in neurocysticercosis (NCC). Both conditions exhibit diverse clinical manifestations, and the potential impact of concomitant HIV infection especially prevalent in sub-Saharan Africa on peripheral and CNS immune responses remains poorly understood. This study aimed to identify the potential impact of HIV coinfection in CC and NCC patients., Methodology: A nested study within a cross-sectional analysis in two Tanzanian regions was performed and 234 participants (110 HIV+ and 124 HIV-) were tested for cysticercosis antibodies, antigens, CD4 counts and serum Th1 and Th2 cytokines via multiplex bead-based immunoassay. 127 cysticercosis seropositive individuals underwent cranial computed tomography (CCT) and clinical symptoms were assessed. Multiple regression analyses were performed to identify factors associated with cytokine modulation due to HIV in CC and NCC patients., Results: Serologically, 18.8% tested positive for cysticercosis antibodies, with no significant difference HIV+ and HIV+. A significantly higher rate of cysticercosis antigen positivity was found in HIV+ individuals (43.6%) compared to HIV- (28.2%) (p = 0.016). CCT scans revealed that overall 10.3% had active brain cysts (NCC+). Our study found no significant changes in the overall cytokine profiles between HIV+ and HIV- participants coinfected CC and NCC, except for IL-5 which was elevated in HIV+ individuals with cysticercosis. Furthermore, HIV infection in general was associated with increased levels of pro-and some anti-inflammatory cytokines e.g. TNF-α, IL-8, and IFN-γ. However, based on the interaction analyses, no cytokine changes were observed due to HIV in CC or NCC patients., Conclusions: In conclusion, while HIV infection itself significantly modulates levels of key cytokines such as TNF-α, IL-8, and IFN-γ, it does not modulate any cytokine changes due to CC or NCC. This underscores the dominant influence of HIV on the immune system and highlights the importance of effective antiretroviral therapy in managing immune responses in individuals coinfected with HIV and CC/NCC., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Lema et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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37. High prevalence of SARS-CoV-2 antibodies and low prevalence of SARS-CoV-2 RNA in cats recently exposed to human cases.
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Daigle L, Khalid H, Gagnon CA, Arsenault J, Bienzle D, Bisson SK, Blais MC, Denis-Robichaud J, Forest C, Grenier St-Sauveur V, Koszegi M, MacNicol J, Nantel-Fortier N, Nury C, Prystajecky N, Fraser E, Carabin H, and Aenishaenslin C
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- Cats, Animals, Cross-Sectional Studies, Humans, Female, Male, Prevalence, SARS-CoV-2 immunology, Cat Diseases virology, Cat Diseases epidemiology, RNA, Viral, Antibodies, Viral blood, COVID-19 veterinary, COVID-19 epidemiology, COVID-19 diagnosis, COVID-19 virology
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Background: The primary objective of this cross-sectional study, conducted in Québec and Bristish Columbia (Canada) between February 2021 and January 2022, was to measure the prevalence of viral RNA in oronasal and rectal swabs and serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) amongst cats living in households with at least one confirmed human case. Secondary objectives included a description of potential risk factors for the presence of SARS-CoV-2 antibodies and an estimation of the association between the presence of viral RNA in swabs as well as SARS-CoV-2 antibodies and clinical signs. Oronasal and rectal swabs and sera were collected from 55 cats from 40 households at most 15 days after a human case confirmation, and at up to two follow-up visits. A RT-qPCR assay and an ELISA were used to detect SARS-CoV-2 RNA in swabs and serum SARS-CoV-2 IgG antibodies, respectively. Prevalence and 95% Bayesian credibility intervals (BCI) were calculated, and associations were evaluated using prevalence ratio and 95% BCI obtained from Bayesian mixed log-binomial models., Results: Nine (0.16; 95% BCI = 0.08-0.28) and 38 (0.69; 95% BCI = 0.56-0.80) cats had at least one positive RT-qPCR and at least one positive serological test result, respectively. No risk factor was associated with the prevalence of SARS-CoV-2 serum antibodies. The prevalence of clinical signs suggestive of COVID-19 in cats, mainly sneezing, was 2.12 (95% BCI = 1.03-3.98) times higher amongst cats with detectable viral RNA compared to those without., Conclusions: We showed that cats develop antibodies to SARS-CoV-2 when exposed to recent human cases, but detection of viral RNA on swabs is rare, even when sampling occurs soon after confirmation of a human case. Moreover, cats with detectable levels of virus showed clinical signs more often than cats without signs, which can be useful for the management of such cases., (© 2024. The Author(s).)
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- 2024
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38. Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis.
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Pamela BE, Patole C, Thamizhmaran S, Moorthy RK, Manoj J, Thanigachalam A, Hocker JRS, Drevets DA, Oommen A, Rajshekhar V, Carabin H, and Vasudevan P
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- Humans, Adult, Adolescent, Animals, Middle Aged, Young Adult, Male, Female, Chromatography, Liquid, Tandem Mass Spectrometry, Mass Spectrometry, Serum chemistry, Neurocysticercosis blood, Neurocysticercosis parasitology, Taenia solium immunology, Helminth Proteins blood
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Neurocysticercosis (NCC), a major cause of global acquired epilepsy, results from Taenia solium larval brain infection. T. solium adult worms release large numbers of infective eggs into the environment contributing to high levels of exposure in endemic areas. This study identifies T. solium proteins in the sera of individuals with and without NCC using mass spectrometry to examine exposure in endemic regions. Forty-seven patients (18-51 years), 24 parenchymal NCC (pNCC), 8 epilepsy of unknown aetiology, 7 glioma, 8 brain tuberculoma, and 7 healthy volunteers were studied. Trypsin digested sera were subject to liquid chromatography-tandem mass spectrometry and spectra of 375-1700 m/z matched against T. solium WormBase ParaSite database with MaxQuant software to identify T. solium proteins. Three hundred and nineteen T. solium proteins were identified in 87.5% of pNCC and 56.6% of non-NCC subjects. Three hundred and four proteins were exclusive to pNCC sera, seven to non-NCC sera and eight in both. Ten percent, exhibiting immune-modulatory properties, originated from the oncosphere and cyst vesicular fluid. In conclusion, in endemic regions, T. solium proteins are detected in sera of individuals with and without pNCC. The immunomodulatory nature of these proteins may influence susceptibility and course of infection., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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39. One Health communication channels: a qualitative case study of swine influenza in Canada in 2020.
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Denis-Robichaud J, Hindmarch S, Nswal NN, Mutabazi JC, D'Astous M, Gangbè M, Osborn A, Zarowsky C, Rees EE, and Carabin H
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- Humans, Animals, Swine, Communication, Alberta, One Health, Health Communication, Influenza, Human epidemiology, Orthomyxoviridae Infections
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Background: With increased attention to the importance of integrating the One Health approach into zoonotic disease surveillance and response, a greater understanding of the mechanisms to support effective communication and information sharing across animal and human health sectors is needed. The objectives of this qualitative case study were to describe the communication channels used between human and animal health stakeholders and to identify the elements that have enabled the integration of the One Health approach., Methods: We combined documentary research with interviews with fifteen stakeholders to map the communication channels used in human and swine influenza surveillance in Alberta, Canada, as well as in the response to a human case of H1N2v in 2020. A thematic analysis of the interviews was also used to identify the barriers and facilitators to communication among stakeholders from the animal and human health sectors., Results: When a human case of swine influenza emerged, the response led by the provincial Chief Medical Officer of Health involved players at various levels of government and in the human and animal health sectors. The collaboration of public and animal health laboratories and of the swine sector, in addition to the information available through the surveillance systems in place, was swift and effective. Elements identified as enabling smooth communication between the human and animal health systems included preexisting relationships between the various stakeholders, a relationship of trust between them (e.g., the swine sector and their perception of government structures), the presence of stakeholders acting as permanent liaisons between the ministries of health and agriculture, and stakeholders' understanding of the importance of the One Health approach., Conclusions: Information flows through formal and informal channels and both structural and relational features that can support rapid and effective communication in infectious disease surveillance and outbreak response., (© 2024. The Author(s).)
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- 2024
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40. Self-reported tick exposure as an indicator of Lyme disease risk in an endemic region of Quebec, Canada.
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Bowser N, Bouchard C, Sautié Castellanos M, Baron G, Carabin H, Chuard P, Leighton P, Milord F, Richard L, Savage J, Tardy O, and Aenishaenslin C
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- Animals, Humans, Quebec epidemiology, Self Report, Cross-Sectional Studies, Canada epidemiology, Lyme Disease epidemiology, Ixodes, Tick Bites
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Background: Lyme disease (LD) and other tick-borne diseases are emerging across Canada. Spatial and temporal LD risk is typically estimated using acarological surveillance and reported human cases, the former not considering human behavior leading to tick exposure and the latter occurring after infection., Objectives: The primary objective was to explore, at the census subdivision level (CSD), the associations of self-reported tick exposure, alternative risk indicators (predicted tick density, eTick submissions, public health risk level), and ecological variables (Ixodes scapularis habitat suitability index and cumulative degree days > 0 °C) with incidence proportion of LD. A secondary objective was to explore which of these predictor variables were associated with self-reported tick exposure at the CSD level., Methods: Self-reported tick exposure was measured in a cross-sectional populational health survey conducted in 2018, among 10,790 respondents living in 116 CSDs of the Estrie region, Quebec, Canada. The number of reported LD cases per CSD in 2018 was obtained from the public health department. Generalized linear mixed-effets models accounting for spatial autocorrelation were built to fulfill the objectives., Results: Self-reported tick exposure ranged from 0.0 % to 61.5 % (median 8.9 %) and reported LD incidence rates ranged from 0 to 324 cases per 100,000 person-years, per CSD. A positive association was found between self-reported tick exposure and LD incidence proportion (ß = 0.08, CI = 0.04,0.11, p < 0.0001). The best-fit model included public health risk level (AIC: 144.2), followed by predicted tick density, ecological variables, self-reported tick exposure and eTick submissions (AIC: 158.4, 158.4, 160.4 and 170.1 respectively). Predicted tick density was the only significant predictor of self-reported tick exposure (ß = 0.83, CI = 0.16,1.50, p = 0.02)., Discussion: This proof-of-concept study explores self-reported tick exposure as a potential indicator of LD risk using populational survey data. This approach may offer a low-cost and simple tool for evaluating LD risk and deserves further evaluation., Competing Interests: Declaration of Competing Interest The authors declare they have nothing to disclose., (Copyright © 2023. Published by Elsevier GmbH.)
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- 2024
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41. Seroprevalence and risk factors for Taenia spp infection in pigs in Kongwa and Songwe districts, Tanzania: A cross-sectional study.
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Wilson C, Mdegela RH, Nonga HE, Makingi G, Churi AJ, Stelzle D, Mkupasi EM, Schmidt V, Carabin H, Winkler AS, and Ngowi HA
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Taenia solium porcine cysticercosis (PCC) is widespread in many low- and middle-income countries (LMICs) where free-range pig rearing is common and hygienic standards are subpar. A cross-sectional survey was conducted in 42 villages between June and September 2019 (14 in Songwe district, southwest Tanzania, and 28 in Kongwa district, central Tanzania). Using a commercial Ag-ELISA kit (apDia, Belgium), circulating antigens of Taenia spp in pig serum were identified and used to calculate the PCC seroprevalence. The study recruited 692 randomly selected households, sampling one pig per household. The relationship between each risk factor and the seroprevalence of PCC at the household and village levels was analysed using mixed logistic regression models. The findings showed that approximately 28% of the pigs were reared in free-range settings, the proportion of households with latrines across the districts was 92%. Twenty-seven percent of households with latrines had water and soap available for hand washing. Sixty-seven (9.7%) tested positive for PCC based on Ag-ELISA. The overall seroprevalence in Kongwa and Songwe districts was 7.3% and 14.0% respectively. In addition, the overall village Ag-ELISA positivity was 9.3%, with an interquartile range (IQR) of 4.6% - 14.1%. Increasing the age of the pig (OR = 3.13 95% CI = 1.48 - 6.60; p = 0.003), pig originating from outside the household (OR = 0.5 95% CI = 0.25 - 0.99; p = 0.05), and pigs kept in a household that practised deworming (OR = 2.23 95% CI = 1.08 - 4.61; p = 0.03) were important risk factors associated with PCC positivity. Therefore, the high seroprevalence of PCC, up to 14%, calls for rapid and effective control actions such as vaccination and treatment of pigs against PCC, and public health education emphasises on indoor pig rearing, hygienic practices and regular use of latrines. Our findings also point to a potential danger of Taenia. spp infection indicating the possibility of people carrying the adult parasite Taenia solium not only in the rural communities of Kongwa and Songwe districts but also in the urban areas of Tanzania, where pigs from these areas are transported for consumption. To develop effective management measures, further research on taeniasis and cysticercosis in the human population is required., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
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- 2023
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42. Correlation between Monocyte Gene Expression and Inflammation on Brain Imaging in Patients with Solitary Cerebral Cysticercus Granuloma.
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Pamela BE, Thamizhmaran S, Manoj J, Thanigachalam A, Carabin H, Prabhakaran V, Moorthy RK, Oommen A, Drevets DA, and Rajshekhar V
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- Animals, Humans, Monocytes, Seizures complications, Granuloma diagnosis, Inflammation complications, Edema complications, Gene Expression, Neuroimaging, Cysticercus, Neurocysticercosis complications
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Prior work has shown that 14 monocyte genes are upregulated in patients with different forms of parenchymal neurocysticercosis, including solitary cysticercus granuloma (SCG). The aim of this study was to investigate whether changes in inflammation associated with SCG seen on follow-up brain imaging are also reflected in changes in expression of these 14 genes. Peripheral blood CD14+ monocytes were isolated from 20 patients with SCG at initial diagnosis and at clinical and imaging follow-up of 6 months or more. Expressions of 14 target monocyte genes were determined by quantitative polymerase chain reaction at each visit. At a median follow-up of 14 months, the SCG had resolved in 11 patients, was persistent in four patients, and had calcified in five patients. Edema seen in the initial imaging in 17 patients had resolved in 15 patients and was markedly reduced in two patients. The expression levels of the monocyte genes LRRFIP2, TAXIBP1, and MZB1 were significantly lower at follow-up, regardless of the status of SCG on follow-up imaging. Our findings show that expression levels of monocyte genes involved with inflammatory processes decrease in patients with SCG concomitant with follow-up imaging that reveals a reduction in inflammation as revealed by complete or near-complete resolution of edema, as well as resolution or reduction in the enhancement of the granuloma.
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- 2023
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43. Professional characteristics, attitudes, and practices associated with stress and quality of life among Canadian animal health workers.
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Denis-Robichaud J, Millar N, Hongoh V, Carabin H, Richard L, and Aenishaenslin C
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- Animals, Cross-Sectional Studies, Canada epidemiology, Euthanasia, Animal, Attitude, Quality of Life, COVID-19 epidemiology, COVID-19 veterinary
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Objective: To describe the knowledge, attitudes, and practices (KAP) towards COVID-19 of Canadian companion animal health workers (AHW); to measure their perceived stress and quality of life (QoL); and to explore professional risk factors associated with stress and QoL., Sample: We sampled 436 companion animal veterinarians and technicians., Procedure: The study had cross-sectional and cohort components. It was conducted online in August to December 2020, and repeated in May to July 2021, using a questionnaire assessing the respondents' professional characteristics, COVID-19 KAP, perceived stress, and QoL., Results: Overall, AHW had sufficient knowledge of COVID-19 transmission, and reported having adopted good preventive practices. Since the beginning of the pandemic, participants reported increases in new clients (76%), in refusal of new clients (53%), and in pet euthanasia (24%). Increased client refusal and pet euthanasia were associated with greater stress and poorer professional QoL, whereas perceived susceptibility to and adoption of measures against COVID-19 were associated with lower stress and better QoL., Conclusion and Clinical Relevance: For AHW, professional characteristics were associated with stress and professional QoL. This information is important for developing strategies to cope with the ongoing shortage of AHW and with future public health crises., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)
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- 2023
44. Geostatistical analysis of active human cysticercosis: Results of a large-scale study in 60 villages in Burkina Faso.
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Dermauw V, Van De Vijver E, Dorny P, Giorgi E, Ganaba R, Millogo A, Tarnagda Z, Cissé AK, and Carabin H
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- Animals, Humans, Swine, Burkina Faso epidemiology, Cross-Sectional Studies, Prevalence, Cysticercosis parasitology, Taenia solium, Swine Diseases parasitology
- Abstract
Cysticercosis is a neglected tropical disease caused by the larval stage of the zoonotic tapeworm (Taenia solium). While there is a clear spatial component in the occurrence of the parasite, no geostatistical analysis of active human cysticercosis has been conducted yet, nor has such an analysis been conducted for Sub-Saharan Africa, albeit relevant for guiding prevention and control strategies. The goal of this study was to conduct a geostatistical analysis of active human cysticercosis, using data from the baseline cross-sectional component of a large-scale study in 60 villages in Burkina Faso. The outcome was the prevalence of active human cysticercosis (hCC), determined using the B158/B60 Ag-ELISA, while various environmental variables linked with the transmission and spread of the disease were explored as potential explanatory variables for the spatial distribution of T. solium. A generalized linear geostatistical model (GLGM) was run, and prediction maps were generated. Analyses were conducted using data generated at two levels: individual participant data and grouped village data. The best model was selected using a backward variable selection procedure and models were compared using likelihood ratio testing. The best individual-level GLGM included precipitation (increasing values were associated with an increased odds of positive test result), distance to the nearest river (decreased odds) and night land temperature (decreased odds) as predictors for active hCC, whereas the village-level GLGM only retained precipitation and distance to the nearest river. The range of spatial correlation was estimated at 45.0 [95%CI: 34.3; 57.8] meters and 28.2 [95%CI: 14.0; 56.2] km for the individual- and village-level datasets, respectively. Individual- and village-level GLGM unravelled large areas with active hCC predicted prevalence estimates of at least 4% in the south-east, the extreme south, and north-west of the study area, while patches of prevalence estimates below 2% were seen in the north and west. More research designed to analyse the spatial characteristics of hCC is needed with sampling strategies ensuring appropriate characterisation of spatial variability, and incorporating the uncertainty linked to the measurement of outcome and environmental variables in the geostatistical analysis. Trial registration: ClinicalTrials.gov; NCT0309339., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Dermauw et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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45. A Method to Create Directed Acyclic Graphs from Cycles of Transmission of Zoonotic and Vector-Borne Infectious Agents.
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Jackson EE, Janitz AE, and Carabin H
- Subjects
- Animals, Causality, Risk Factors, Confounding Factors, Epidemiologic
- Abstract
Background: The life cycles of zoonotic and vector-borne diseases can be complex. This complexity makes it challenging to identify factors that confound the association between an exposure of interest and infection in one of the susceptible hosts. In epidemiology, directed acyclic graphs (DAGs) can be used to visualize the relationships between exposures and outcomes and also to identify which factors confound the association between exposure and the outcome of interest. However, DAGs can only be used in situations where no cycle exists in the causal relationships being represented. This is problematic for infectious agents that cycle between hosts. Zoonoses and vector-borne diseases pose additional challenges with DAG construction since multiple required or optional hosts of different species may be part of the cycle. Methods: We review the existing examples of DAGs created for nonzoonotic infectious agents. We then demonstrate how to cut the transmission cycle to create DAGs where infection of a specific host species is the outcome of interest. We adapt our method to create DAGs using examples of transmission and host characteristics common to many zoonotic and vector-borne infectious agents. Results: We demonstrate our method using the transmission cycle of West Nile virus to create a simple transmission DAG that lacks a cycle. Conclusions: Using our work, investigators can create DAGs to help identify confounders of the relationships between modifiable risk factors and infection. Ultimately, a better understanding and control of confounding in measuring the impact of such risk factors can be used to inform health policy, guide public health and animal health interventions, and uncover gaps needing further research attention.
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- 2023
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46. Assessing transmission risks and control strategy for monkeypox as an emerging zoonosis in a metropolitan area.
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Yuan P, Tan Y, Yang L, Aruffo E, Ogden NH, Bélair J, Heffernan J, Arino J, Watmough J, Carabin H, and Zhu H
- Subjects
- Male, Humans, Animals, Mice, Rats, Homosexuality, Male, Monkeypox virus, Zoonoses epidemiology, Zoonoses prevention & control, Sciuridae, Mpox (monkeypox) epidemiology, Mpox (monkeypox) prevention & control, Sexual and Gender Minorities
- Abstract
To model the spread of monkeypox (MPX) in a metropolitan area for assessing the risk of possible outbreaks, and identifying essential public health measures to contain the virus spread. The animal reservoir is the key element in the modeling of zoonotic disease. Using a One Health approach, we model the spread of the MPX virus in humans considering potential animal hosts such as rodents (e.g., rats, mice, squirrels, chipmunks, etc.) and emphasize their role and transmission of the virus in a high-risk group, including gay and bisexual men-who-have-sex-with-men (gbMSM). From model and sensitivity analysis, we identify key public health factors and present scenarios under different transmission assumptions. We find that the MPX virus may spill over from gbMSM high-risk groups to broader populations if the efficiency of transmission increases in the higher-risk group. However, the risk of outbreak can be greatly reduced if at least 65% of symptomatic cases can be isolated and their contacts traced and quarantined. In addition, infections in an animal reservoir will exacerbate MPX transmission risk in the human population. Regions or communities with a higher proportion of gbMSM individuals need greater public health attention. Tracing and quarantine (or "effective quarantine" by postexposure vaccination) of contacts with MPX cases in high-risk groups would have a significant effect on controlling the spreading. Also, monitoring for animal infections would be prudent., (© 2022 Wiley Periodicals LLC.)
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- 2023
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47. Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions.
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Haffner JJ, Katemauswa M, Kagone TS, Hossain E, Jacobson D, Flores K, Parab AR, Obregon-Tito AJ, Tito RY, Reyes LM, Troncoso-Corzo L, Guija-Poma E, Meda N, Carabin H, Honap TP, Sankaranarayanan K, Lewis CM Jr, and McCall LI
- Subjects
- Humans, RNA, Ribosomal, 16S genetics, Metabolomics methods, Metabolome, Industrial Development, Microbiota genetics
- Abstract
The metabolome is a central determinant of human phenotypes and includes the plethora of small molecules produced by host and microbiome or taken up from exogenous sources. However, studies of the metabolome have so far focused predominantly on urban, industrialized populations. Through an untargeted metabolomic analysis of 90 fecal samples from human individuals from Africa and the Americas-the birthplace and the last continental expansion of our species, respectively-we characterized a shared human fecal metabolome. The majority of detected metabolite features were ubiquitous across populations, despite any geographic, dietary, or behavioral differences. Such shared metabolite features included hyocholic acid and cholesterol. However, any characterization of the shared human fecal metabolome is insufficient without exploring the influence of industrialization. Here, we show chemical differences along an industrialization gradient, where the degree of industrialization correlates with metabolomic changes. We identified differential metabolite features such as amino acid-conjugated bile acids and urobilin as major metabolic correlates of these behavioral shifts. Additionally, coanalyses with over 5,000 publicly available human fecal samples and cooccurrence probability analyses with the gut microbiome highlight connections between the human fecal metabolome and gut microbiome. Our results indicate that industrialization significantly influences the human fecal metabolome, but diverse human lifestyles and behavior still maintain a shared human fecal metabolome. This study represents the first characterization of the shared human fecal metabolome through untargeted analyses of populations along an industrialization gradient. IMPORTANCE As the world becomes increasingly industrialized, understanding the biological consequences of these lifestyle shifts and what it means for past, present, and future human health is critical. Indeed, industrialization is associated with rises in allergic and autoimmune health conditions and reduced microbial diversity. Exploring these health effects on a chemical level requires consideration of human lifestyle diversity, but understanding the significance of any differences also requires knowledge of what molecular components are shared between human groups. Our study reveals the key chemistry of the human gut as defined by varied industrialization-based differences and ubiquitous shared features. Ultimately, these novel findings extend our knowledge of human molecular biology, especially as it is influenced by lifestyle and behavior, and provide steps toward understanding how human biology has changed over our species' history.
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- 2022
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48. Modeling vaccination and control strategies for outbreaks of monkeypox at gatherings.
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Yuan P, Tan Y, Yang L, Aruffo E, Ogden NH, Bélair J, Arino J, Heffernan J, Watmough J, Carabin H, and Zhu H
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- Humans, Immunization Programs, Public Health, Contact Tracing, Disease Outbreaks prevention & control, Vaccination
- Abstract
Background: The monkeypox outbreak in non-endemic countries in recent months has led the World Health Organization (WHO) to declare a public health emergency of international concern (PHEIC). It is thought that festivals, parties, and other gatherings may have contributed to the outbreak., Methods: We considered a hypothetical metropolitan city and modeled the transmission of the monkeypox virus in humans in a high-risk group (HRG) and a low-risk group (LRG) using a Susceptible-Exposed-Infectious-Recovered (SEIR) model and incorporated gathering events. Model simulations assessed how the vaccination strategies combined with other public health measures can contribute to mitigating or halting outbreaks from mass gathering events., Results: The risk of a monkeypox outbreak was high when mass gathering events occurred in the absence of public health control measures. However, the outbreaks were controlled by isolating cases and vaccinating their close contacts. Furthermore, contact tracing, vaccinating, and isolating close contacts, if they can be implemented, were more effective for the containment of monkeypox transmission during summer gatherings than a broad vaccination campaign among HRG, when accounting for the low vaccination coverage in the overall population, and the time needed for the development of the immune responses. Reducing the number of attendees and effective contacts during the gathering could also prevent a burgeoning outbreak, as could restricting attendance through vaccination requirements., Conclusion: Monkeypox outbreaks following mass gatherings can be made less likely with some restrictions on either the number and density of attendees in the gathering or vaccination requirements. The ring vaccination strategy inoculating close contacts of confirmed cases may not be enough to prevent potential outbreaks; however, mass gatherings can be rendered less risky if that strategy is combined with public health measures, including identifying and isolating cases and contact tracing. Compliance with the community and promotion of awareness are also indispensable to containing the outbreak., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Yuan, Tan, Yang, Aruffo, Ogden, Bélair, Arino, Heffernan, Watmough, Carabin and Zhu.)
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- 2022
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49. "COP26: what is the message for public health?" Response from the Université de Montréal One Health initiative.
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Aenishaenslin C, Batal M, Boiteux M, Bouchard M, Brun Y, Brodeur J, Carabin H, Carrier J, Kasisi R, Kritikou E, Lavoie JP, Lavoie-Tremblay M, Merry L, Monnais L, Sauvé S, Stafford L, Michel JJT, and Tremblay H
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- Humans, Universities, One Health, Public Health
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- 2022
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50. Effectiveness of non-pharmaceutical interventions to reduce SARS-CoV-2 transmission in Canada and their association with COVID-19 hospitalization rates.
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Rees EE, Avery BP, Carabin H, Carson CA, Champredon D, de Montigny S, Dougherty B, Nasri BR, and Ogden NH
- Abstract
Background: Non-pharmaceutical interventions (NPIs) aim to reduce the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections mostly by limiting contacts between people where virus transmission can occur. However, NPIs limit social interactions and have negative impacts on economic, physical, mental and social well-being. It is, therefore, important to assess the impact of NPIs on reducing the number of coronavirus disease 2019 (COVID-19) cases and hospitalizations to justify their use., Methods: Dynamic regression models accounting for autocorrelation in time series data were used with data from six Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, Québec) to assess 1) the effect of NPIs (measured using a stringency index) on SARS-CoV-2 transmission (measured by the effective reproduction number), and 2) the effect of the number of hospitalized COVID-19 patients on the stringency index., Results: Increasing stringency index was associated with a statistically significant decrease in the transmission of SARS-CoV-2 in Alberta, Saskatchewan, Manitoba, Ontario and Québec. The effect of stringency on transmission was time-lagged in all of these provinces except for Ontario. In all provinces except for Saskatchewan, increasing hospitalization rates were associated with a statistically significant increase in the stringency index. The effect of hospitalization on stringency was time-lagged., Conclusion: These results suggest that NPIs have been effective in Canadian provinces, and that their implementation has been, in part, a response to increasing hospitalization rates of COVID-19 patients., Competing Interests: Competing interests None.
- Published
- 2022
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