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Your search keyword '"Cai, Yuqiao"' showing total 8 results
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8 results on '"Cai, Yuqiao"'

3. Annual variation in the gut microbiota of captive adult spotted seals, Phoca largha.

Author

Liu, Youlin, Gao, Xianggang, Cai, Yuqiao, Wang, Zhen, Zhang, Zhiyuan, Lu, Zhichuang, Xing, Yankuo, Luo, Jun, Zhang, Zhige, Shi, Hongyue, Li, Yingdong, and Tian, Jiashen

Subjects
GUT microbiome, MARINE mammals, ADULTS, SPRING, AUTUMN
Abstract

This study monitored monthly variations in the gut microbiota of three captive adult spotted seals from October 2021 to September 2022. Fecal samples were collected regularly, and 16S rRNA sequencing was used for analysis. A total of 5,502,711 raw sequence reads were generated, revealing 11,978 Amplifying Subsequence Variants across different classification levels. Firmicutes and Proteobacteria were dominant, showing consistent patterns with varying relative abundances over time, indicating stability with seasonal variations. Alpha and beta diversity analyses showed significant variations, with higher diversity in May and June and notable changes between spring and autumn. Intriguingly, nonendemic Proteobacteria were present, suggesting external influences such as interactions with zookeepers or exposure to public programs. Long-term monitoring of microbial communities in captive marine mammals is crucial for understanding impacts from diet, medical history, and enclosure conditions, optimizing their health and wellbeing. This research highlights the importance of microbiota monitoring for managing captive marine mammal health. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Role of H2B mono-ubiquitination in the initiation and progression of cancer

Author

Tong-Cun Zhang, Sa Zhou, Lijun Jin, Xiaoqin Wang, Cai Yuqiao, Liu Xinyi, and Wenjian Ma

Subjects
0301 basic medicine, Cancer Research, Transcription Elongation, Genetic, DNA Repair, Ubiquitin-Protein Ligases, medicine.disease_cause, Histones, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Neoplasms, medicine, Histone H2B, Humans, Radiology, Nuclear Medicine and imaging, Epigenetics, Precision Medicine, biology, business.industry, Carcinoma, Ubiquitination, Cancer, Hematology, General Medicine, DNA, Neoplasm, medicine.disease, Ubiquitinated Proteins, Ubiquitin ligase, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Histone, Oncology, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, Disease Progression, Carcinogenesis, business, Protein Processing, Post-Translational, Ubiquitin Thiolesterase, DNA Damage
Abstract

Numerous epigenetic alterations are observed in cancer cells, and dysregulation of mono-ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a dynamic post-translational histone modification associated with transcriptional elongation and DNA damage response. Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22). RNF20/40 is often altered in the primary tumors including colorectal cancer, breast cancer, ovarian cancer, prostate cancer, and lung cancer, and the loss of H2Bub1 is usually associated with poor prognosis in tumor patients. The purpose of this review is to summarize the current knowledge of H2Bub1 in transcription, DNA damage response and primary tumors. This review also provides novel options for exploiting the potential therapeutic target H2Bub1 in personalized cancer therapy.

Published
2020

8. Role of H2B monoubiquitination in the initiation and progression of cancer

Author

Zhou, Sa, Cai, Yuqiao, Liu, Xinyi, Jin, Lijun, Wang, Xiaoqin, Ma, Wenjian, and Zhang, Tongcun

Abstract

Numerous epigenetic alterations are observed in cancer cells, and dysregulation of monoubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a dynamic post-translational histone modification associated with transcriptional elongation and DNA damage response. Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22). RNF20/40 is often altered in the primary tumors including colorectal cancer, breast cancer, ovarian cancer, prostate cancer, and lung cancer, and the loss of H2Bub1 is usually associated with poor prognosis in tumor patients. The purpose of this review is to summarize the current knowledge of H2Bub1 in transcription, DNA damage response and primary tumors. This review also provides novel options for exploiting the potential therapeutic target H2Bub1 in personalized cancer therapy.

Published
2021
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