71 results on '"Cabré E"'
Search Results
2. Requerimientos terapéuticos en el tratamiento de mantenimiento de la proctitis ulcerosa
- Author
-
Calafat, M., Lobatón, T., Mañosa, M., Larraín, M., Caballero, N., Cabré, E., and Domènech, E.
- Published
- 2016
- Full Text
- View/download PDF
3. Mitos, leyendas y verdades sobre las recomendaciones dietéticas en la enfermedad inflamatoria intestinal
- Author
-
Cabré, E.
- Published
- 2016
- Full Text
- View/download PDF
4. Phenotype and natural history of elderly onset inflammatory bowel disease: a multicentre, case‐control study
- Author
-
Mañosa, M., Calafat, M., de Francisco, R., García, C., Casanova, M. J., Huelín, P., Calvo, M., Tosca, J., Fernández‐Salazar, L., Arajol, C., Zabana, Y., Bastida, G., Hinojosa, J., Márquez, L., Barreiro‐de‐Acosta, M., Calvet, X., Monfort, D., Gómez‐Garcia, M. R., Rodríguez, E., Huguet, J. M., Rojas‐Feria, M., Hervias, D., Atienza, R., Busquets, D., Zapata, E., Dueñas, C., Charro, M., Martínez‐Cerezo, F. J., Plaza, R., Vázquez, J. M., Gisbert, J. P., Cañete, F., Cabré, E., Domènech, E., Arajol, Clàudia, Atienza, Ramón, Barreiro‐de‐Acosta, Manuel, Bastida, Guillermo, Busquets, David, Calafat, Margalida, Calvet, Xavier, Calvo, Marta, Cabré, Eduard, Cañete, Fiorella, Casanova, Mª José, Charro, Mara, Dueñas, Carmen, Domènech, Eugeni, de Francisco, Ruth, Fernández‐Salazar, Luis, García, Carmen, Gómez‐Garcia, María Rosario, Hervias, Daniel, Hinojosa, Joaquín, Huelín, Patricia, Huguet, José Mª, Mañosa, Míriam, Márquez, Lucía, Martínez‐Cerezo, Francisco J., Monfort, David, Gisbert, Javier P., Plaza, Rocío, Rodríguez, Esther, Rojas‐Feria, María, Tosca, Joan, Vázquez, Juan M., Zabana, Yamile, and Zapata, Eva
- Published
- 2018
- Full Text
- View/download PDF
5. N032 Impact of pain due to subcutaneous administration of a biological drug
- Author
-
Gely, C, Marin, L, Gordillo, J, Mañosa, M, Bertoletti, F, Cañete, F, Gonzalez-Muñosa, C, Cabré, E, Domènech, E, and Garcia-Planella, E
- Published
- 2018
- Full Text
- View/download PDF
6. P480 Characteristics of drug-induced lupus 2° to anti-TNF agents in inflammatory bowel disease patients and evolution after switch to a second anti-TNF
- Author
-
Mañosa, M., Corrales, G., Olivares, D., Vicuña, M., Aguas, M., Busquets, D., Tosca, J., Lla, J., Mesonero, F., García-Tejero, I., Ferreiro, R., Cabré, E., and Domènech, E.
- Published
- 2017
- Full Text
- View/download PDF
7. HLA-DQ2/DQ8 and HLA-DQB1*02 homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population
- Author
-
Ruiz-Ortiz, E., Montraveta, M., Cabré, E., Herrero-Mata, M. J., Pujol-Borrell, R., Palou, E., and Faner, R.
- Published
- 2014
- Full Text
- View/download PDF
8. 20/21 Central Event in Spain of the International Day of Light: outreach and citizen engagement in time of pandemic
- Author
-
Pérez-Cabré, E., Millán, M. S., Armengol, J., Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, and Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge
- Subjects
Light ,Llum ,Ciències de la visió::Òptica física::Llum [Àrees temàtiques de la UPC] - Abstract
The 3rd central IDL Event in Spain probably gathered the largest number of activities for the 16th May commemoration in 2021. Conferences, debates, workshops, exhibitions, light shows, and photo contests, adapted to severe constraints due to the pandemic, achieved the participation of a wide and diverse audience.
- Published
- 2021
9. P437 Risk of immunomediated adverse events or secondary loss of response to infliximab in elderly patients with inflammatory bowel disease: a cohort study of the ENEIDA registry
- Author
-
Calafat, M, primary, Mañosa, M, additional, Panes, J, additional, Nos, P, additional, Iglesias, E, additional, Vera, I, additional, López-Sanromán, A, additional, Guardiola, J, additional, Taxonera, C, additional, Mínguez, M, additional, Martín, M D, additional, de Castro, L, additional, Riestra, S, additional, Rivero, M, additional, García-Planella, E, additional, Calvet, X, additional, García-López, S, additional, Andreu, M, additional, Gomollón, F, additional, Barrio, J, additional, Esteve, M, additional, Rodríguez, A, additional, Gisbert, J P, additional, Gutierrez, A, additional, Hinojosa, J, additional, Argüelles, F, additional, Busquets, D, additional, Bujanda, L, additional, Lázaro, J, additional, Sicilia, B, additional, Merino, O, additional, Martínez, P, additional, Bermejo, F, additional, Lorente, R, additional, Barreiro-de-Acosta, M, additional, Rodríguez, C, additional, Fe, M, additional, Piqueras, M, additional, Romero, P, additional, Rodríguez, E, additional, Roncero, Ó, additional, Llaó, J, additional, Alcaín, G, additional, Riera, J, additional, Sierra, M, additional, Fdez. Salazar, L I, additional, Jair, V, additional, Navarro, M, additional, Montoro, M A, additional, Muñoz, C, additional, Lucendo, A J, additional, Van Domselaar, M, additional, Moraleja, I, additional, Huguet, J M, additional, Ramos, L, additional, Ramírez, P, additional, Almeda, P, additional, Pajares, R, additional, Khorrami, S, additional, Madrigal, R E, additional, Sesé, E, additional, Trapero, A M, additional, Legido, J, additional, Abad, Á, additional, Cañete, F, additional, Cabré, E, additional, and Domènech, E, additional
- Published
- 2019
- Full Text
- View/download PDF
10. P495 Spacing the administration interval of anti-TNF agents: a valid strategy for patients with inflammatory bowel disease?
- Author
-
Torres, P, primary, Núñez, L, additional, Aguilar, A, additional, Mañosa, M, additional, Mesonero, F, additional, Cañete, F, additional, Calafat, M, additional, Fernandez, C, additional, Cabré, E, additional, López-Sanromán, A, additional, and Domènech, E, additional
- Published
- 2019
- Full Text
- View/download PDF
11. P345 Risk of long-term post-operative recurrence (POR) in Crohn’s disease patients with a first postoperative normal endoscopic assessment under thiopurine prevention
- Author
-
Mañosa, M, primary, Puig, M, additional, Torres, P F, additional, Cañete, F, additional, Troya, J, additional, Calafat, M, additional, Parés, D, additional, Cabré, E, additional, and Domènech, E, additional
- Published
- 2019
- Full Text
- View/download PDF
12. ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach
- Author
-
Lorén, V, primary, Garcia-Jaraquemada, A, additional, Naves, J E, additional, Carmona, X, additional, Mañosa, M, additional, Aransay, A M, additional, Lavin, J L, additional, Sánchez, I, additional, Cabré, E, additional, Manyé, J, additional, and Domènech, E, additional
- Published
- 2018
- Full Text
- View/download PDF
13. P631 Treatment of established post-operative recurrence of Crohn’s disease with anti-TNF agents: Preliminary data of a multicentre, nationwide study
- Author
-
Cañete, F, primary, Mañosa, M, additional, Barreiro-de Acosta, M, additional, Iglesias, E, additional, Ríos, R, additional, González-Sueyro, R C, additional, Villoria, A, additional, Navarro-Llavat, M, additional, Rodriguez-Lago, I, additional, Taxonera, C, additional, Navarro, P, additional, López, P, additional, Ramos, L, additional, Van Domselaar, M, additional, Algaba, A, additional, Casanova, M J, additional, Muñoz-Villafranca, C, additional, Pajares, R, additional, Sampedro, M, additional, Rivero, M, additional, Delgado-Guillena, P G, additional, Hernández, A, additional, Aràjol, C, additional, Pordomingo, A F, additional, Piqueras, M, additional, Sáinz-Arnau, E, additional, Benítez-Leiva, O, additional, Ramírez-de la Piscina, P, additional, Cabré, E, additional, and Domènech, E, additional
- Published
- 2018
- Full Text
- View/download PDF
14. P609 Uncertain usefulness of infliximab trough levels for therapeutic decision-making in inflammatory bowel disease patients on infliximab maintenance therapy
- Author
-
Cañete, F, primary, Lobatón, T, additional, Cabré, E, additional, Mañosa, M, additional, Teniente, A, additional, Clos, A, additional, Torres, P, additional, Valldosera, G, additional, Martínez-Cáceres, E, additional, and Domènech, E, additional
- Published
- 2018
- Full Text
- View/download PDF
15. P663 Primary prevention of post-operative recurrence of Crohn’s disease with anti-TNF agents in real life. Preliminary data from the Spanish ENEIDA registry
- Author
-
Cañete, F, primary, Mañosa, M, additional, Casanova, M J, additional, González-Sueyro, R C, additional, Barrio, J, additional, Bermejo, F, additional, Nos, P, additional, Iglesias, E, additional, Garcia-Planella, E, additional, Perez-Calle, J L, additional, Ramos, L, additional, De Francisco, R, additional, Rivero, M, additional, Montserrat, A, additional, Navarro, P, additional, Taxonera, C, additional, Hinojosa, J, additional, Núñez, A, additional, Navarro-Llavat, M, additional, Ramírez-de la Piscina, P, additional, Fernández, L, additional, Almela, P, additional, Ríos, R, additional, Clos, A, additional, Cabré, E, additional, and Domènech, E, additional
- Published
- 2018
- Full Text
- View/download PDF
16. Roadmap on optical security
- Author
-
Javidi, B., Carnicer, A., Yamaguchi, M., Nomura, T., Pérez-Cabré, E., Millán, M. S., Nishchal, N. K., Torroba, R., Barrera, J. F., He, W., Peng, X., Stern, A., Rivenson, Y., Alfalou, A., Brosseau, C., Guo, C., Sheridan, J. T., Situ, G., Naruse, M., Matsumoto, T., Juvells, I., Tajahuerce, E., Lancis, J., Chen, W., Chen, X., Pinkse, P.W.H., Mosk, A. P., Markman, A., Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, Sub Nanophotonics, Nanophotonics, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Universitat de Barcelona, Nanophotonics, Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, and Complex Photonic Systems
- Subjects
genetic structures ,Computer science ,Ciencias Físicas ,Optical engineering ,Reconeixement òptic de formes ,Encryption ,Multiple scattering of light, Physical-unclonable function ,02 engineering and technology ,Xifratge (Informàtica) ,01 natural sciences ,Disk encryption hardware ,law.invention ,purl.org/becyt/ford/1 [https] ,020210 optoelectronics & photonics ,Physical-unclonable function ,Speckle ,Computer security ,law ,0202 electrical engineering, electronic engineering, information engineering ,Comunicacions òptiques ,Data encryption (Computer science) ,SECURITY ,Optical communications ,Multiple scattering of light ,Processament òptic de dades ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Disk encryption theory ,Nanoscience ,Optical data processing ,Informàtica::Seguretat informàtica::Criptografia [Àrees temàtiques de la UPC] ,CIENCIAS NATURALES Y EXACTAS ,METIS-320419 ,Seguretat informàtica ,010309 optics ,Optics ,Òptica -- Tecnologia ,0103 physical sciences ,Optical pattern recognition ,business.industry ,Nanotecnologia ,SPECKLE ,Física ,Information security ,purl.org/becyt/ford/1.3 [https] ,eye diseases ,Astronomía ,ENCRYPTION ,Probabilistic encryption ,Encriptació de dades (Informàtica) ,IR-102887 ,Security ,40-bit encryption ,business ,Cryptanalysis ,Optical communications--Security measures - Abstract
Information security and authentication are important challenges facing society. Recent attacks by hackers on the databases of large commercial and financial companies have demonstrated that more research and development of advanced approaches are necessary to deny unauthorized access to critical data. Free space optical technology has been investigated by many researchers in information security, encryption, and authentication. The main motivation for using optics and photonics for information security is that optical waveforms possess many complex degrees of freedom such as amplitude, phase, polarization, large bandwidth, nonlinear transformations, quantum properties of photons, and multiplexing that can be combined in many ways to make information encryption more secure and more difficult to attack. This roadmap article presents an overview of the potential, recent advances, and challenges of optical security and encryption using free space optics. The roadmap on optical security is comprised of six categories that together include 16 short sections written by authors who have made relevant contributions in this field. The first category of this roadmap describes novel encryption approaches, including secure optical sensing which summarizes double random phase encryption applications and flaws [Yamaguchi], the digital holographic encryption in free space optical technique which describes encryption using multidimensional digital holography [Nomura], simultaneous encryption of multiple signals [Pérez-Cabré], asymmetric methods based on information truncation [Nishchal], and dynamic encryption of video sequences [Torroba]. Asymmetric and one-way cryptosystems are analyzed by Peng. The second category is on compression for encryption. In their respective contributions, Alfalou and Stern propose similar goals involving compressed data and compressive sensing encryption. The very important area of cryptanalysis is the topic of the third category with two sections: Sheridan reviews phase retrieval algorithms to perform different attacks, whereas Situ discusses nonlinear optical encryption techniques and the development of a rigorous optical information security theory. The fourth category with two contributions reports how encryption could be implemented at the nano- or micro-scale. Naruse discusses the use of nanostructures in security applications and Carnicer proposes encoding information in a tightly focused beam. In the fifth category, encryption based on ghost imaging using single-pixel detectors is also considered. In particular, the authors [Chen, Tajahuerce] emphasize the need for more specialized hardware and image processing algorithms. Finally, in the sixth category, Mosk and Javidi analyze in their corresponding papers how quantum imaging can benefit optical encryption systems. Sources that use few photons make encryption systems much more difficult to attack, providing a secure method for authentication., Centro de Investigaciones Ópticas, Consejo Nacional de Investigaciones Científicas y Técnicas
- Published
- 2016
17. Spectral radiance of blue light filters on ophthalmic lenses
- Author
-
Fernández, C., primary, Argilés, M., additional, Pérez-Cabré, E., additional, and Cardona, G., additional
- Published
- 2017
- Full Text
- View/download PDF
18. ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach.
- Author
-
Lorén, V, Garcia-Jaraquemada, A, Naves, J E, Carmona, X, Mañosa, M, Aransay, A M, Lavin, J L, Sánchez, I, Cabré, E, Manyé, J, and Domènech, E
- Abstract
Background and Aims Steroid-refractoriness is a common and unpredictable phenomenon in ulcerative colitis [UC], but there are no conclusive studies on the molecular functions involved. We aimed to assess the mechanism of action related to steroid failure by integrating transcriptomic data from UC patients, and updated molecular data on UC and glucocorticoids. Methods MicroRNA [miRNA] and mRNA expression were evaluated by sequencing and microarrays, respectively, from rectal biopsies of patients with moderately-to-severe active UC, obtained before and on the third day of steroid treatment. The differential results were integrated into the mathematical models generated by a systems biology approach. Results This computational approach identified 18 proteins that stand out either by being associated with the mechanism of action or by providing a means to classify the patients according to steroid response. Their biological functions have been linked to inflammation, glucocorticoid-induced transcription and angiogenesis. All the selected proteins except ANP32E [a chaperone which has been linked to the exchange of H2A.z histone and promotes glucocorticoid receptor-induced transcription] had previously been related to UC and/or glucocorticoid-induced biological actions. Western blot and immunofluorescence assays confirmed the implication of this chaperone in steroid failure in patients with active UC. Conclusions A systems biology approach allowed us to identify a comprehensive mechanism of action of steroid-refractoriness, highlighting the key role of steroid-induced transcription and the potential implication of ANP32E in this phenomenon. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
19. Roadmap on optical security
- Author
-
Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, Sub Nanophotonics, Nanophotonics, Javidi, B., Carnicer, A., Yamaguchi, M., Nomura, T., Pérez-Cabré, E., Millán, M. S., Nishchal, N. K., Torroba, R., Barrera, J. F., He, W., Peng, X., Stern, A., Rivenson, Y., Alfalou, A., Brosseau, C., Guo, C., Sheridan, J. T., Situ, G., Naruse, M., Matsumoto, T., Juvells, I., Tajahuerce, E., Lancis, J., Chen, W., Chen, X., Pinkse, P.W.H., Mosk, A. P., Markman, A., Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, Sub Nanophotonics, Nanophotonics, Javidi, B., Carnicer, A., Yamaguchi, M., Nomura, T., Pérez-Cabré, E., Millán, M. S., Nishchal, N. K., Torroba, R., Barrera, J. F., He, W., Peng, X., Stern, A., Rivenson, Y., Alfalou, A., Brosseau, C., Guo, C., Sheridan, J. T., Situ, G., Naruse, M., Matsumoto, T., Juvells, I., Tajahuerce, E., Lancis, J., Chen, W., Chen, X., Pinkse, P.W.H., Mosk, A. P., and Markman, A.
- Published
- 2016
20. Roadmap on optical security
- Author
-
Nanophotonics, Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, Javidi, B., Carnicer, A., Yamaguchi, M., Nomura, T., Pérez-Cabré, E., Millán, M. S., Nishchal, N. K., Torroba, R., Barrera, J. F., He, W., Peng, X., Stern, A., Rivenson, Y., Alfalou, A., Brosseau, C., Guo, C., Sheridan, J. T., Situ, G., Naruse, M., Matsumoto, T., Juvells, I., Tajahuerce, E., Lancis, J., Chen, W., Chen, X., Pinkse, P.W.H., Mosk, A. P., Markman, A., Nanophotonics, Sub String Theory Cosmology and ElemPart, Sub Physical Oceanography, Sub Mathematical Modeling, Javidi, B., Carnicer, A., Yamaguchi, M., Nomura, T., Pérez-Cabré, E., Millán, M. S., Nishchal, N. K., Torroba, R., Barrera, J. F., He, W., Peng, X., Stern, A., Rivenson, Y., Alfalou, A., Brosseau, C., Guo, C., Sheridan, J. T., Situ, G., Naruse, M., Matsumoto, T., Juvells, I., Tajahuerce, E., Lancis, J., Chen, W., Chen, X., Pinkse, P.W.H., Mosk, A. P., and Markman, A.
- Published
- 2016
21. Falsa hipersensibilidad a mesalazina como causa de escalamiento terapéutico
- Author
-
Calafat, M., primary, Depreux, N., additional, Mañosa, M., additional, Cabré, E., additional, Zacarías, L., additional, and Domènech, E., additional
- Published
- 2015
- Full Text
- View/download PDF
22. Photon-counting multifactor optical encryption and authentication
- Author
-
Pérez-Cabré, E, primary, Mohammed, E A, additional, Millán, M S, additional, and Saadon, H L, additional
- Published
- 2015
- Full Text
- View/download PDF
23. HLA-DQ2/DQ8 andHLA-DQB1*02homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population
- Author
-
Ruiz-Ortiz, E., primary, Montraveta, M., additional, Cabré, E., additional, Herrero-Mata, M. J., additional, Pujol-Borrell, R., additional, Palou, E., additional, and Faner, R., additional
- Published
- 2014
- Full Text
- View/download PDF
24. New Insights into the Exosome-Induced Migration of Uveal Melanoma Cells and the Pre-Metastatic Niche Formation in the Liver.
- Author
-
Ramos R, Vinyals A, Campos-Martin R, Cabré E, Bech JJ, Vaquero J, Gonzalez-Sanchez E, Bertran E, Ferreres JR, Lorenzo D, De La Torre CG, Fabregat I, Caminal JM, and Fabra À
- Abstract
UM is an aggressive intraocular tumor characterized by high plasticity and a propensity to metastasize in the liver. However, the underlying mechanisms governing liver tropism remain poorly understood. Given the emerging significance of exosomes, we sought to investigate the contribution of UM-derived exosomes to specific steps of the metastatic process. Firstly, we isolated exosomes from UM cells sharing a common genetic background and different metastatic properties. A comparison of protein cargo reveals an overrepresentation of proteins related to cytoskeleton remodeling and actin filament-based movement in exosomes derived from the parental cells that may favor the detachment of cells from the primary site. Secondly, we assessed the role of macrophages in reprogramming the HHSCs by exosomes. The activation of HHSCs triggered a pro-inflammatory and pro-fibrotic environment through cytokine production, upregulation of extracellular matrix molecules, and the activation of signaling pathways. Finally, we found that activated HHSCs promote increased adhesion and migration of UM cells. Our findings shed light on the pivotal role of exosomes in pre-metastatic niche construction in the liver.
- Published
- 2024
- Full Text
- View/download PDF
25. Loss of Blink Regularity and Its Impact on Ocular Surface Exposure.
- Author
-
Cardona G, Argilés M, and Pérez-Cabré E
- Abstract
(1) Background: Changes in blink parameters have been found to influence ocular surface exposure, eliciting symptoms of dry eye and ocular signs. The aim of the study was to highlight the relevance of including blink regularity as a new parameter to fully characterize blinking; (2) Methods: A novel characterization of blink parameters is described, including spontaneous eyeblink rate (SEBR), percentage of incomplete blinks, and blink regularity. A pilot study was designed in which tear film break-up time (TFBUT), blink parameters, and the time percentage of ocular surface exposure were determined in eight subjects (52.0 ± 16.6 years, 4 females) in three experimental conditions (baseline, reading a hard-copy text, and reading from an electronic display). Blink parameters were monitored through asynchronous image analysis of one minute video segments; (3) Results: All blink parameters were influenced by experimental conditions. A trend was observed in which both reading tasks resulted in an increase in ocular surface exposure, mainly related to a combination of reduced SEBR, increased percentage of incomplete blinks, and loss of blink regularity; (4) Conclusions: A complete characterization of blink parameters is relevant to better understand ocular dryness related to surface exposure and to advice patients towards a reeducation of their blinking habits.
- Published
- 2023
- Full Text
- View/download PDF
26. Nonlinear Encryption for Multiple Images Based on a Joint Transform Correlator and the Gyrator Transform.
- Author
-
Perez RA, Vilardy JM, Pérez-Cabré E, Millán MS, and Torres CO
- Abstract
A novel nonlinear encryption-decryption system based on a joint transform correlator (JTC) and the Gyrator transform (GT) for the simultaneous encryption and decryption of multiple images in grayscale is proposed. This security system features a high level of security for the single real-valued encrypted image and a high image quality for the multiple decrypted images. The multispectral or color images are considered as a special case, taking each color component as a grayscale image. All multiple grayscale images (original images) to encrypt are encoded in phase and placed in the input plane of the JTC at the same time without overlapping. We introduce two random-phase masks (RPMs) keys for each image to encrypt at the input plane of the JTC-based encryption system. The total number of the RPM keys is given by the double of the total number of the grayscale images to be encrypted. The use of several RPMs as keys improves the security of the encrypted image. The joint Gyrator power distribution (JGPD) is the intensity of the GT of the input plane of the JTC. We obtain only a single real-valued encrypted image with a high level of security for all the multiple grayscale images to encrypt by introducing two new suitable nonlinear modifications on the JGPD. The security keys are given by the RPMs and the rotation angle of the GT. The decryption system is implemented by two successive GTs applied to the encrypted image and the security keys given by the RPMs and considering the rotation angle of the GT. We can simultaneously retrieve the various information of the original images at the output plane of the decryption system when all the security keys are correct. Another result due to the appropriate definition of the two nonlinear operations applied on the JGPD is the retrieval of the multiple decrypted images with a high image quality. The numerical simulations are computed with the purpose of demonstrating the validity and performance of the novel encryption-decryption system.
- Published
- 2023
- Full Text
- View/download PDF
27. Double Image Encryption System Using a Nonlinear Joint Transform Correlator in the Fourier Domain.
- Author
-
Perez RA, Pérez-Cabré E, Vilardy JM, Millán MS, and Torres CO
- Abstract
In this work, we present a new nonlinear joint transform correlator (JTC) architecture in the Fourier domain (FD) for the encryption and decryption of two simultaneous images. The main features of the proposed system are its increased level of security, the obtention of a single real-valued encrypted signal that contains the ciphered information of the two primary images and, additionally, a high image quality for the two final decrypted signals. The two images to be encrypted can be either related to each other, or independent signals. The encryption system is based on the double random phase encoding (DRPE), which is implemented by using a nonlinear JTC in the FD. The input plane of the JTC has four non-overlapping data distributions placed side-by-side with no blank spaces between them. The four data distributions are phase-only functions defined by the two images to encrypt and four random phase masks (RPMs). The joint power spectrum (JPS) is produced by the intensity of the Fourier transform (FT) of the input plane of the JTC. One of the main novelties of the proposal consists of the determination of the appropriate two nonlinear operations that modify the JPS distribution with a twofold purpose: to obtain a single real-valued encrypted image with a high level of security and to improve the quality of the decrypted images. The security keys of the encryption system are represented by the four RPMs, which are all necessary for a satisfactory decryption. The decryption system is implemented using a 4 f -processor where the encrypted image and the security keys given by the four RPMs are introduced in the proper plane of the processor. The double image encryption system based on a nonlinear JTC in the FD increases the security of the system because there is a larger key space, and we can simultaneously validate two independent information signals (original images to encrypt) in comparison to previous similar proposals. The feasibility and performance of the proposed double image encryption and decryption system based on a nonlinear JTC are validated through computational simulations. Finally, we additionally comment on the proposed security system resistance against different attacks based on brute force, plaintext and deep learning.
- Published
- 2023
- Full Text
- View/download PDF
28. Orthotopic murine xenograft model of uveal melanoma with spontaneous liver metastasis.
- Author
-
Ramos R, Cabré E, Vinyals A, Lorenzo D, Ferreres JR, Varela M, Gomá M, Paules MJ, Gutierrez C, Piulats JM, Fabra À, and Caminal JM
- Subjects
- Adult, Humans, Animals, Mice, Heterografts, Disease Models, Animal, Melanoma pathology, Skin Neoplasms, Uveal Neoplasms pathology, Liver Neoplasms secondary
- Abstract
Uveal melanoma is the most common intraocular malignancy in adults. Despite the effective primary treatment, up to 50% of patients with uveal melanoma will develop metastatic lesions mainly in the liver, which are resistant to conventional chemotherapy and lead to patient's death. To date, no orthotopic murine models of uveal melanoma which can develop spontaneous metastasis are available for preclinical studies. Here, we describe a spontaneous metastatic model of uveal melanoma based on the orthotopic injection of human uveal melanoma cells into the suprachoroidal space of immunodeficient NSG mice. All mice injected with bioluminescent OMM2.5 ( n = 23) or MP41 ( n = 19) cells developed a primary tumor. After eye enucleation, additional bioluminescence signals were detected in the lungs and in the liver. At necropsy, histopathological studies confirmed the presence of lung metastases in 100% of the mice. Liver metastases were assessed in 87 and in 100% of the mice that received OMM2.5 or MP41 cells, respectively. All tumors and metastatic lesions expressed melanoma markers and the signaling molecules insulin-like growth factor type I receptor and myristoylated alanine-rich C-kinase substrate, commonly activated in uveal melanoma. The novelty of this orthotopic mouse xenograft model is the development of spontaneous metastases in the liver from the primary site, reproducing the organoespecificity of metastasis observed in uveal melanoma patients. The faster growth and the high metastatic incidence may be attributed at least in part, to the severe immunodeficiency of NSG mice. This model may be useful for preclinical testing of targeted therapies with potential uveal melanoma antimetastatic activity and to study the mechanisms involved in liver metastasis., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
29. The Genetic Diversity and Dysfunctionality of Catalase Associated with a Worse Outcome in Crohn's Disease.
- Author
-
Iborra M, Moret I, Busó E, García-Giménez JL, Ricart E, Gisbert JP, Cabré E, Esteve M, Márquez-Mosquera L, García-Planella E, Guardiola J, Pallardó FV, Serena C, Algaba-Chueca F, Domenech E, Nos P, and Beltrán B
- Subjects
- Humans, Catalase genetics, Catalase metabolism, Retrospective Studies, Antioxidants metabolism, Genotype, Inflammation complications, Genetic Variation, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Case-Control Studies, Crohn Disease metabolism
- Abstract
Chronic gut inflammation in Crohn’s disease (CD) is associated with an increase in oxidative stress and an imbalance of antioxidant enzymes. We have previously shown that catalase (CAT) activity is permanently inhibited by CD. The purpose of the study was to determine whether there is any relationship between the single nucleotide polymorphisms (SNPs) in the CAT enzyme and the potential risk of CD associated with high levels of oxidative stress. Additionally, we used protein and regulation analyses to determine what causes long-term CAT inhibition in peripheral white mononuclear cells (PWMCs) in both active and inactive CD. We first used a retrospective cohort of 598 patients with CD and 625 age-matched healthy controls (ENEIDA registry) for the genotype analysis. A second human cohort was used to study the functional and regulatory mechanisms of CAT in CD. We isolated PWMCs from CD patients at the onset of the disease (naïve CD patients). In the genotype-association SNP analysis, the CAT SNPs rs1001179, rs475043, and rs525938 showed a significant association with CD (p < 0.001). Smoking CD patients with the CAT SNP rs475043 A/G genotype had significantly more often penetrating disease (p = 0.009). The gene expression and protein levels of CAT were permanently reduced in the active and inactive CD patients. The inhibition of CAT activity in the PWMCs of the CD patients was related to a low concentration of CAT protein caused by the downregulation of CAT-gene transcription. Our study suggests an association between CAT SNPs and the risk of CD that may explain permanent CAT inhibition in CD patients together with low CAT gene and protein expression.
- Published
- 2022
- Full Text
- View/download PDF
30. Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn's disease.
- Author
-
Zabana Y, Lorén V, Domènech E, Aterido A, Garcia-Jaraquemada A, Julià A, Vicario M, Pedrosa E, Ferreiro M, Troya J, Lozano JJ, Sarrias MR, Cabré E, Mañosa M, and Manyé J
- Subjects
- Adult, Caco-2 Cells, Case-Control Studies, Cell Differentiation, Crohn Disease metabolism, Gene Expression Regulation, Humans, Inflammation metabolism, Membrane Glycoproteins genetics, Oxygen Consumption, Crohn Disease genetics, Epithelial Cells physiology, Ileum cytology, Membrane Glycoproteins metabolism, Transcriptome
- Abstract
Crohn's disease (CD) is a complex and multifactorial illness. There are still considerable gaps in our knowledge regarding its pathophysiology. A transcriptomic approach could shed some light on little-known biological alterations of the disease. We therefore aimed to explore the ileal transcriptome to gain knowledge about CD. We performed whole transcriptome gene expression analysis on ileocecal resections from CD patients and inflammatory bowel disease-free controls, as well as on a CD-independent cohort to replicate selected results. Normalized data were hierarchically clustered, and gene ontology and the molecular network were studied. Cell cultures and molecular methods were used for further evaluations. Genome-wide expression data analysis identified a robust transmembrane immunoglobulin domain-containing 1 (TMIGD1) gene underexpression in CD tissue, which was even more marked in inflamed ileum, and which was replicated in the validation cohort. Immunofluorescence showed TMIGD1 to be located in the apical microvilli of well-differentiated enterocytes but not in intestinal crypt. This apical TMIGD1 was lower in the noninflamed tissue and almost disappeared in the inflamed mucosa of surgical resections. In vitro studies showed hypoxic-dependent TMIGD1 decreased its expression in enterocyte-like cells. The gene enrichment analysis linked TMIGD1 with cell recovery and tissue remodeling in CD settings, involving guanylate cyclase activities. Transcriptomics may be useful for finding new targets that facilitate studies of the CD pathology. This is how TMIGD1 was identified in CD patients, which was related to multiciliate ileal epithelial cell differentiation. NEW & NOTEWORTHY This is a single-center translational research study that aimed to look for key targets involved in Crohn's disease and define molecular pathways through different functional analysis strategies. With this approach, we have identified and described a novel target, the almost unknown TMIGD1 gene, which may be key in the recovery of injured mucosa involving intestinal epithelial cell differentiation.
- Published
- 2020
- Full Text
- View/download PDF
31. Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry.
- Author
-
Cañete F, Mañosa M, Casanova MJ, González-Sueyro RC, Barrio J, Bermejo F, Nos P, Iglesias-Flores E, García-Planella E, Pérez-Calle JL, Vicente R, Vera M, Ramos L, Rivero M, De Francisco R, Montserrat A, Benítez O, Navarro P, Taxonera C, Hinojosa E, Márquez-Mosquera L, Navarro-Llavat M, Ramírez-de la Piscina P, Gomollón F, Rodríguez-Alonso L, Núñez-Alonso A, Fernández-Salazar L, Almela P, Ríos León R, De Castro L, Gisbert JP, Ricart E, Cabré E, and Domènech E
- Subjects
- Adult, Colonoscopy, Crohn Disease surgery, Female, Humans, Immunosuppressive Agents therapeutic use, Intestinal Mucosa pathology, Logistic Models, Male, Middle Aged, Multivariate Analysis, Recurrence, Registries, Retrospective Studies, Secondary Prevention, Spain, Tumor Necrosis Factor-alpha antagonists & inhibitors, Adalimumab therapeutic use, Crohn Disease drug therapy, Crohn Disease prevention & control, Infliximab therapeutic use
- Abstract
Background: Anti-tumor necrosis factor agents (anti-TNFs) are efficacious at preventing the postoperative recurrence (POR) of Crohn disease, as demonstrated in 2 randomized controlled trials. However, real-life data for infliximab or adalimumab in this setting are scarce. Our aim was to assess both the efficiency of anti-TNFs at preventing early POR of Crohn disease in clinical practice and the associated risk factors for POR., Methods: Patients in whom anti-TNFs were prescribed for the prevention of POR within 3 months after ileocolonic resection and who had an endoscopic assessment within 18 months were identified from the ENEIDA registry. Clinical and endoscopic features were collected within 18 months after surgery., Results: In total, 152 patients were included (55 treated with infliximab, 97 with adalimumab, and 39% with concomitant immunosuppressants). Anti-TNF treatment was started after a median time of 29 days (IQR 13-44) after surgery. Eighty-two percent of patients had at least one risk factor for POR, and 82% had been exposed to anti-TNFs before the index surgery. Overall, 34% had endoscopic POR (as defined using a Rutgeerts endoscopic score > i1); 14% had advanced endoscopic POR (>i2); and 20% had clinical POR, with no differences between infliximab and adalimumab. In the multivariate analysis, only perianal disease (odds ratio 2.73, 95% confidence interval [CI] 1.26-5.91) and rectal involvement (odds ratio 2.79, 95% CI 1.09-7.14) were independent predictors of endoscopic POR., Conclusions: In clinical practice, anti-TNFs for the prevention of POR of Crohn disease are frequently used in patients experienced with anti-TNFs and with concomitant immunosuppressants. The efficacy of infliximab and adalimumab for POR prevention is similar and in accordance with the results obtained in randomized controlled trials., (© 2019 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2019
- Full Text
- View/download PDF
32. Characteristics of inflammatory bowel disease in patients of Roma/Gypsy ethnicity. A case-control study.
- Author
-
Cabré E, Mañosa M, Marín I, Martín-Mateos R, Iglesias-Flores E, Barreiro-de-Acosta M, Nos P, Busquets D, Menchén LA, López-Sanromán A, and Domènech E
- Subjects
- Adolescent, Adult, Case-Control Studies, Databases, Factual, Female, Humans, Immunosuppressive Agents therapeutic use, Inflammatory Bowel Diseases therapy, Male, Spain epidemiology, Young Adult, Inflammatory Bowel Diseases ethnology, Phenotype, Roma statistics & numerical data
- Abstract
Background: Peculiarities of inflammatory bowel disease (IBD) have been explored in ethnic groups, such as Asians, Hispanics, and Afro-Americans, but not in other ethnic minorities, such as Roma/Gypsies., Methods: In a retrospective, hospital-based study, all adult Roma/Gypsy patients included in the IBD databases of seven Spanish centres were identified as cases. For each Roma/Gypsy patient, a Caucasian patient, matched for several demographic features, was searched as a control. Data on phenotypic features, therapeutic requirements, and familial aggregation were recorded., Results: Sixty-eight Roma/Gypsy patients were identified, 29 of them being women. The mean age at diagnosis of IBD was 24.9±9.5years, and the mean time elapsed since diagnosis was 96.6±72.2months. Roma/Gypsy IBD patients showed a significantly higher rate of familial aggregation (43%) than their Caucasian controls (9%) (p=0.00001). CD in Roma/Gypsies had more often a complicated pattern (mainly penetrating) while UC patients showed a marked trend to more often developing extraintestinal manifestations. In addition, Roma/Gypsy IBD patients had a somewhat greater need for immunosuppressants, biological agents or surgery., Conclusions: These are the first data on IBD in Roma/Gypsy patients. Familial aggregation is the most prominent feature in these patients, suggesting a predominant role of genetics in its pathogenesis., (Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
33. Nivolumab-induced immune-mediated colitis: an ulcerative colitis look-alike-report of new cases and review of the literature.
- Author
-
Cañete F, Mañosa M, Lobatón T, Mesonero F, Rodríguez-Lago I, Cabré E, Cabriada JL, López-Sanromán A, and Domènech E
- Subjects
- Aged, Aged, 80 and over, Colitis, Ulcerative pathology, Colonoscopy, Female, Humans, Male, Middle Aged, Treatment Outcome, Colitis, Ulcerative chemically induced, Colitis, Ulcerative immunology, Nivolumab adverse effects
- Abstract
Purpose: Nivolumab, a monoclonal antibody-targeting programmed cell death protein-1, is being increasingly used for the treatment of some advanced neoplasms. Several of its adverse effects are a result of the upregulation of T cells, with colitis as one of the most severe, and a challenging differential diagnosis with ulcerative colitis. However, few real-life clinical practice cases have been reported beyond trials. Our aim was to report a series of new cases, reviewing previously communicated endoscopic-proven nivolumab-induced colitis., Method: All patients treated with nivolumab in three university centers were identified and those who developed immune-mediated colitis (defined as the presence of diarrhea and evidence of colitis demonstrated by colonoscopy) were described. Additionally, a review of case reports of nivolumab-induced colitis reported in the literature up to March 2018 was performed., Results: Six new cases of nivolumab-induced colitis and 13 previously reported cases out of randomized clinical trials are described. Colonoscopy showed a mucosal pattern mimicking ulcerative colitis in a large proportion of patients. Clostridium difficile superinfection was observed in two out of 19 cases. All but three patients definitively discontinued nivolumab therapy. Most patients were initially managed with oral or intravenous corticosteroids, but five of them required rescue therapy with infliximab., Conclusions: Nivolumab-induced colitis may mimic ulcerative colitis. Steroid therapy (oral or intravenously) is often efficient, but one-fourth of patients need rescue therapy with anti-TNF. Intestinal superinfection with Clostridium difficile or cytomegalovirus should be ruled out before starting immunosuppressive therapy.
- Published
- 2019
- Full Text
- View/download PDF
34. Prognostic Value of the Burden of Cytomegalovirus Colonic Reactivation Evaluated by Immunohistochemical Staining in Patients with Active Ulcerative Colitis.
- Author
-
Clos-Parals A, Rodríguez-Martínez P, Cañete F, Mañosa M, Ruiz-Cerulla A, José Paúles M, Llaó J, Gordillo J, Fumagalli C, Garcia-Planella E, Ojanguren I, Cabré E, Guardiola J, and Domènech E
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Age Factors, Antiviral Agents therapeutic use, Azathioprine therapeutic use, Colitis, Ulcerative complications, Colitis, Ulcerative drug therapy, Colon pathology, Cytomegalovirus Infections complications, Female, Humans, Immunohistochemistry, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Prognosis, Tumor Necrosis Factor-alpha antagonists & inhibitors, Valganciclovir therapeutic use, Colectomy, Colitis, Ulcerative surgery, Colon virology, Cytomegalovirus physiology, Cytomegalovirus Infections drug therapy, Virus Activation
- Abstract
Background: Colonic cytomegalovirus [CMV] reactivation has been involved in steroid refractoriness in patients with active ulcerative colitis [UC]. The benefits of antiviral therapy in this clinical setting are still under debate, but the burden of viral reactivation has been associated with a poorer outcome in some studies. Our aim was to assess whether the burden of CMV reactivation measured by the number of viral inclusions by immunohistochemistry [IHC-CMV] is associated with a risk of colectomy., Methods: Biopsy sets of UC patients with positive IHC-CMV were identified from the Pathology departments of three university hospitals. All biopsies were reviewed by expert pathologists, and the maximum number of IHC-CMV-positive cells in each biopsy set was re-assessed. Epidemiological and clinical features and clinical outcomes were recorded., Results: Forty-six positive IHC-CMV cases with UC were included. At the time of CMV reactivation, 70% were receiving corticosteroids, 33% azathioprine, and 24% anti-tumour necrosis factor [TNF] agents. Thirty-two patients [70%] were treated with antiviral therapy. The median number of IHC-CMV-positive cells was 2 cells/biopsy [IQR 1-4]. Fourteen patients [30%] underwent colectomy, and 4 of them [29%] showed persistence of CMV in the surgical specimen. In the multivariate analysis, colectomy was only associated with >2 positive cells/biopsy [p = 0.048] and younger age [p = 0.023]., Conclusions: The burden of CMV colonic reactivation in patients with active UC, as measured by IHC, seems to be related to the risk of colectomy, and more data is needed to understand whether antiviral therapy guided by CMV burden will alter the clinical outcome., (Copyright © 2018 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
- Full Text
- View/download PDF
35. Review article: the relationship between obesity, bariatric surgery, and inflammatory bowel disease.
- Author
-
Cañete F, Mañosa M, Clos A, Cabré E, and Domènech E
- Subjects
- Female, Gastrectomy methods, Gastric Bypass methods, Humans, Male, Treatment Outcome, Weight Loss, Bariatric Surgery methods, Colitis, Ulcerative surgery, Crohn Disease surgery, Obesity surgery
- Abstract
Background: The convoluted relationship between obesity, bariatric surgery and inflammatory bowel disease (IBD) is of increasing interest., Aim: To analyse evidence regarding the role of bariatric surgery in the development of de novo IBD and its impact on clinical outcomes and safety in patients with established IBD., Methods: A PubMed/Medline search was performed to identify studies reporting the development of IBD after bariatric surgery and the outcomes of IBD patients after bariatric surgery., Results: Eighty patients were reported to have developed de novo IBD after bariatric surgery (21% ulcerative colitis [UC], 75% Crohn's disease [CD]), mostly females. Roux-en-Y gastric bypass was the most frequent bariatric technique (80%). Symptoms related to IBD occurred within 1 month and 16 years after surgery. Regarding patients with known IBD undergoing bariatric surgery, 60 patients (35 CD, 24 UC, and 1 unclassified colitis) have been reported. Sleeve gastrectomy was the most frequent bariatric procedure, particularly in CD patients. Acute flares after surgery were observed in only four UC patients. In addition, two retrospective population-based studies described perioperative outcomes of bariatric surgery on IBD patients, demonstrating only a significant increase in small bowel obstruction in these patients., Conclusions: Bariatric surgery in carefully selected patients with established IBD is technically feasible and probably safe. Development of de novo IBD should be taken into account in individuals with previous bariatric surgery who develop diarrhoea, anaemia or excessive weight loss., (© 2018 John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
36. Cytomegalovirus primoinfection in inflammatory bowel disease.
- Author
-
Torres P, Lobatón T, Cañete F, Clos A, Mañosa M, Cabré E, and Domènech E
- Subjects
- Adult, Antiviral Agents therapeutic use, Crohn Disease complications, Crohn Disease drug therapy, Cytomegalovirus Infections drug therapy, Disease Susceptibility, Duodenal Ulcer etiology, Duodenal Ulcer virology, Female, Ganciclovir therapeutic use, Gastrointestinal Hemorrhage etiology, Humans, Immunocompromised Host, Immunosuppressive Agents adverse effects, Immunosuppressive Agents therapeutic use, Inflammatory Bowel Diseases drug therapy, Male, Pancytopenia etiology, Valganciclovir therapeutic use, Young Adult, Cytomegalovirus Infections complications, Inflammatory Bowel Diseases complications
- Published
- 2018
- Full Text
- View/download PDF
37. Prevalence and risk factors for colorectal adenomas in patients with ulcerative colitis.
- Author
-
Gordillo J, Zabana Y, Garcia-Planella E, Mañosa M, Llaó J, Gich I, Marín L, Szafranska J, Sáinz S, Bessa X, Cabré E, and Domènech E
- Abstract
Background: Patients with ulcerative colitis (UC) have an increased risk of colorectal cancer. Scarce data regarding the development of adenomas in these patients are available both for normal and colitic mucosa., Objective: The objective of this article is to evaluate the prevalence of adenomatous polyps and associated risk factors in patients with UC., Methods: Patients with UC were identified from the databases of two tertiary referral centers. Medical, endoscopic and histologic reports were reviewed., Results: A total of 403 patients were included (53% male; 33% extensive colitis) and 1065 colonoscopies (median per patient, 2) were recorded and analyzed. Seventy-four adenomas in 47 patients (11.7%) and three cases of colorectal cancer were found during a median follow-up of 6.3 years. The cumulative risk of colorectal adenoma was 4.7%, 16.7%, 23.6% and 34.4% at 10, 20, 30 and 40 years from UC diagnosis, respectively. The cumulative risk of developing metachronous colorectal adenoma was 66.7%, 87.9%, and 90.9% at 5, 10, and 15 years from first adenoma detection. Older age at UC diagnosis and longer disease duration were independent risk factors for colorectal adenoma development., Conclusions: The prevalence of colorectal adenomas among UC patients seems to be higher than previously reported, although lower than in the background population.
- Published
- 2018
- Full Text
- View/download PDF
38. Serial semi-quantitative measurement of fecal calprotectin in patients with ulcerative colitis in remission.
- Author
-
Garcia-Planella E, Mañosa M, Chaparro M, Beltrán B, Barreiro-de-Acosta M, Gordillo J, Ricart E, Bermejo F, García-Sánchez V, Piqueras M, Llaó J, Gisbert JP, Cabré E, and Domènech E
- Subjects
- Adult, Biomarkers analysis, Colonoscopy, Female, Humans, Intestinal Mucosa pathology, Logistic Models, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Recurrence, Remission Induction, Severity of Illness Index, Spain, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Colitis, Ulcerative drug therapy, Feces chemistry, Leukocyte L1 Antigen Complex analysis, Mesalamine therapeutic use
- Abstract
Background: Fecal calprotectin (FC) correlates with clinical and endoscopic activity in ulcerative colitis (UC), and it is a good predictor of relapse. However, its use in clinical practice is constrained by the need for the patient to deliver stool samples, and for their handling and processing in the laboratory. The availability of hand held devices might spread the use of FC in clinical practice., Objectives: To evaluate the usefulness of a rapid semi-quantitative test of FC in predicting relapse in patients with UC in remission., Materials and Methods: Prospective, multicenter study that included UC patients in clinical remission for ≥6 months on maintenance treatment with mesalamine. Patients were evaluated clinically and semi-quantitative FC was measured using a monoclonal immunochromatography rapid test at baseline and every three months until relapse or 12 months of follow-up., Results: One hundred and ninety-one patients had at least one determination of FC. At the end of follow-up, 33 patients (17%) experienced clinical relapse. Endoscopic activity at baseline (p = .043) and having had at least one FC > 60 μg/g during the study period (p = .03) were associated with a higher risk of relapse during follow-up. We obtained a total of 636 semi-quantitative FC determinations matched with a three-month follow-up clinical assessment. Having undetectable FC was inversely associated with early relapse (within three months), with a negative predictive value of 98.6% and a sensitivity of 93.9%., Conclusions: Serial, rapid semi-quantitative measurement of FC may be a useful, easy and cheap monitoring tool for patients with UC in remission.
- Published
- 2018
- Full Text
- View/download PDF
39. Acute histological inflammatory activity is associated with clinical relapse in patients with ulcerative colitis in clinical and endoscopic remission.
- Author
-
Calafat M, Lobatón T, Hernández-Gallego A, Mañosa M, Torres P, Cañete F, Cabré E, Ojanguren I, and Domènech E
- Subjects
- Adult, Aged, Biomarkers metabolism, Colitis, Ulcerative therapy, Colonoscopy, Endpoint Determination, Feces chemistry, Female, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Recurrence, Remission Induction, Retrospective Studies, Risk Factors, Severity of Illness Index, Spain, Tertiary Care Centers, Colitis, Ulcerative pathology, Intestinal Mucosa pathology, Wound Healing
- Abstract
Background: It has been suggested that acute histological activity has a prognostic value in the outcome of ulcerative colitis (UC) patients in clinical and endoscopic remission. Our aim was to assess the role of histology as a risk factor for clinical relapse (CR) in patients in both clinical and endoscopic remission., Methods: Patients with left-sided or extensive UC in clinical and endoscopic remission (Mayo endoscopic subscore ≤1) undergoing colonoscopy for dysplasia surveillance with random colonic biopsies between 2005-2015 were included. Basal plasmacytosis, acute (AHA), and the chronic (CHA) histological inflammatory activity of all biopsy sets were evaluated., Results: One hundred and thirteen patients were included. Median time in clinical remission at inclusion was 27 months (IQR 15-56). Eight percent of patients relapsed within the first year and 33% during the whole follow-up period. In the univariate analysis, the presence of AHA, alone (P=0.048) or together with a past flare within the previous 12 months (P=0.01), was associated with CR within the first year of follow-up. In the multivariate analysis, AHA, together with a flare within the previous 12 months, remained the only risk factor for relapse (RR=7.5; IC95%; 1.8-29.9; P=0.005)., Conclusions: In UC patients in clinical and endoscopic remission, the presence of AHA is a risk factor for clinical relapse., (Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
40. Therapeutic requirements in active ulcerative proctitis: A single-centre study.
- Author
-
Calafat M, Lobatón T, Mañosa M, Marín L, Caballero N, Larraín M, Cabré E, and Domènech E
- Subjects
- Adult, Colitis, Ulcerative complications, Female, Humans, Male, Middle Aged, Proctitis complications, Retrospective Studies, Treatment Outcome, Colitis, Ulcerative drug therapy, Proctitis drug therapy
- Abstract
Background: Ulcerative proctitis (UP) presents distinctive clinical characteristics, outcomes and therapeutic approaches as compared to left-sided and extensive ulcerative colitis (UC)., Aim: To describe the current therapeutic requirements and clinical outcomes in patients with active UP., Methods: Retrospective observational study conducted in a referral IBD centre. Patients with UP in follow-up between 1989 and 2014 were included. The clinical characteristics, as well as the different treatments and drug formulations administered to treat flares, were recorded., Results: Out of 687 UC patients, 101 patients (15%) with UP were included. Median follow-up was 8 years (IQR 3-14) and 49% of patients presented disease activity during the study period. Topical mesalazine monotherapy (90%) was the most commonly administered treatment for disease activity (mostly as suppositories), followed by topical steroids (47%) and oral mesalazine (56%) in monotherapy or combination therapy. Only 14% and 16% of patients required oral prednisone and beclomethasone, respectively., Conclusions: In clinical practice, active UP presents mostly favourable outcomes. Mesalazine suppositories are by far the most used treatment for these patients., (Copyright © 2017 Elsevier España, S.L.U., AEEH y AEG. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
41. Early hospital readmission in decompensated cirrhosis: Incidence, impact on mortality, and predictive factors.
- Author
-
Morales BP, Planas R, Bartoli R, Morillas RM, Sala M, Cabré E, Casas I, and Masnou H
- Subjects
- Aged, Female, Humans, Incidence, Kaplan-Meier Estimate, Logistic Models, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Spain epidemiology, Activities of Daily Living, Educational Status, Liver Cirrhosis mortality, Patient Readmission statistics & numerical data
- Abstract
Background & Aims: The early hospital readmission of patients with decompensated cirrhosis is a current problem. A study is presented on the incidence, the impact on mortality, and the predictive factors of early hospital readmission., Patients and Methods: On the study included 112 cirrhotic patients, discharged after some decompensation between January 2013 and May 2014. Multivariate analyses were performed to identify predictors of early readmission and mortality., Results: The early readmission rate was 29.5%. The predictive factors were male gender (OR: 2.81; 95% CI: 1.07-7.35), Model for End-Stage Liver Disease-sodium score ≥15 (OR: 3.79; 95% CI 1.48-9.64), and Charlson index ≥7 (OR: 4.34, 95% CI 1.65-11.4). This model enabled patients to be classified into low or high risk of early readmissions (13.6% vs. 52.2%). The mortality rate was significantly higher among patients with early readmission (73% vs. 35%) (p<.0001). After adjusting for the Model for End-Stage Liver Disease-sodium score, Charlson index, dependence in activities of daily living, educational status, and number of medications on discharge, the early readmission was independently associated with mortality., Conclusions: Early hospital readmission is common, and is independently associated with mortality. Male gender, MELD-Na ≥15, and Charlson index ≥7 are predictors of early readmission. These results could be used to develop future strategies to reduce early readmission., (Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
42. Epstein-Barr virus-positive mucocutaneous ulcer in Crohn's disease. A condition to consider in immunosuppressed IBD patients.
- Author
-
Juan A, Lobatón T, Tapia G, Mañosa M, Cabré E, and Domènech E
- Subjects
- Adult, Colonoscopy, Crohn Disease immunology, Crohn Disease virology, Diagnosis, Differential, Epstein-Barr Virus Infections diagnosis, Epstein-Barr Virus Infections immunology, Humans, Immunocompromised Host, Immunosuppressive Agents therapeutic use, Lymphoproliferative Disorders, Male, Proctoscopy, Rectum surgery, Ulcer diagnosis, Ulcer immunology, Crohn Disease drug therapy, Epstein-Barr Virus Infections complications, Herpesvirus 4, Human isolation & purification, Rectum pathology, Ulcer virology
- Abstract
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a little known entity that can affect the oropharyngeal mucosa, the gastrointestinal tract and the skin. The main risk factor for the development of this lesion is immunosuppression. Because its features are similar to other Epstein-Barr virus-associated lymphoproliferative disorders, a differential diagnosis can sometimes prove challenging. Here, we report the case of a man diagnosed with Crohn's disease and treated with azathioprine and infliximab who developed ulceration at the rectum that was refractory to conventional medical treatment. Although the histological characteristics were suggestive of an EBVMCU, lymphoproliferative disease could not be ruled out. The patient did not improve after discontinuation of the treatment, a proctectomy was performed and the diagnosis of this disease was confirmed. Although very few cases of EBVMCU affecting the colon have been reported, its diagnosis should be always considered in refractory cases of inflammatory bowel disease with patients undergoing immunosuppressive treatment., (Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
43. AURKA Overexpression Is Driven by FOXM1 and MAPK/ERK Activation in Melanoma Cells Harboring BRAF or NRAS Mutations: Impact on Melanoma Prognosis and Therapy.
- Author
-
Puig-Butille JA, Vinyals A, Ferreres JR, Aguilera P, Cabré E, Tell-Martí G, Marcoval J, Mateo F, Palomero L, Badenas C, Piulats JM, Malvehy J, Pujana MA, Puig S, and Fabra À
- Subjects
- Animals, Cell Line, Tumor, Cell Proliferation genetics, Cell Survival genetics, Humans, Melanoma genetics, Melanoma pathology, Melanoma therapy, Mice, Mitogen-Activated Protein Kinase Kinases metabolism, Proto-Oncogene Proteins B-raf genetics, Sensitivity and Specificity, Signal Transduction, Skin Neoplasms genetics, Skin Neoplasms pathology, Skin Neoplasms therapy, Xenograft Model Antitumor Assays, Aspartate-tRNA Ligase genetics, Aurora Kinase A genetics, Forkhead Box Protein M1 metabolism, Gene Expression Regulation, Neoplastic, Mutation, RNA, Transfer, Amino Acyl genetics
- Abstract
The cell cycle-related genes AURKA and FOXM1 are overexpressed in melanoma. We show here that AURKA overexpression is associated with poor prognosis in three independent cohorts of melanoma patients and correlates with the presence of genomic amplification of AURKA locus and BRAF
V600E mutation. AURKA overexpression may also be driven by increased promoter activation through elements such as ETS and FOXM1 found within the 5' proximal promoter region. Activated MAPK/ERK signaling pathway mediates robust AURKA promoter activation, thereby knockdown of BRAFV600E and ERK inhibition results in reduced AURKA transcription and expression. We show a positive correlation between FOXM1 and AURKA expression in three independent cohorts of melanoma patients. FOXM1 silencing decreases expression of AURKA and late cell cycle genes in melanoma cells. We further found that FOXM1 expression levels are significantly higher in tumors carrying the BRAFV600E mutation compared with the wild-type BRAF (BRAFwt ). Accordingly, the knockdown of BRAFV600E also reduces the expression of FOXM1 in BRAFV600E cells. Moreover, Aurora kinase A and FOXM1 inhibition by either genetic knockdown or pharmacologic inhibitors impair melanoma growth and survival both in culture and in vivo, underscoring their therapeutic value for melanoma patients who fail to benefit from BRAF/MEK signaling inhibition., (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF
44. Comparative Effect of the I3.1 Probiotic Formula in Two Animal Models of Colitis.
- Author
-
Lorén V, Manyé J, Fuentes MC, Cabré E, Ojanguren I, and Espadaler J
- Subjects
- Animals, Colitis chemically induced, Colitis microbiology, Dextran Sulfate adverse effects, Disease Models, Animal, Female, Humans, Interferon-gamma immunology, Interleukin-6 immunology, Lactobacillus plantarum physiology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Colitis drug therapy, Probiotics administration & dosage
- Abstract
Use of probiotic therapy is an active area of investigation to treat intestinal disorders. The clinical benefits of the I3.1 probiotic formula (Lactobacillus plantarum (CECT7484, CECT7485) and P. acidilactici (CECT7483)) were demonstrated in irritable bowel syndrome (IBS) patients in a randomized, double-blind, placebo-controlled clinical trial. The aim of this study was to evaluate the therapeutic effects of I3.1 in two experimental models of colitis, a dextran sulfate sodium (DSS)-induced colitis model and an interleukin (IL)-10-deficient mice model. Colitis was induced in 32 8-week-old Balb/c mice by administering 3% (w/v) DSS in drinking water for 5 days. Probiotics were administered orally (I3.1 or VSL#3, 1 × 10
9 CFU daily) for 10 days before the administration of DSS. Also, probiotics (I3.1 or VSL#3, 1 × 109 CFU daily) were administered orally to 36 6-week-old C57B6J IL-10(-/-) mice for 10 weeks. Body weight was recorded daily. Colon samples were harvested for histological examination and cytokine measurements. Body weight after DSS administration did not change in the I3.1 group, whereas the VSL#3 group had weight loss. Also, I3.1 normalized IL-6 to levels similar to that of healthy controls and significantly increased the reparative histologic score. In the IL-10-deficient model, both VSL#3 and I3.1 reduced the severity of colitis compared to untreated controls, and I3.1 significantly reduced the levels of IFN-γ compared to the other two groups. In conclusion, I3.1 displays a protective effect on two murine models of experimental colitis. Results suggest that the mechanism of action could be different from VSL#3.- Published
- 2017
- Full Text
- View/download PDF
45. Fecal Calprotectin Levels Are Closely Correlated with the Absence of Relevant Mucosal Lesions in Postoperative Crohn's Disease.
- Author
-
Garcia-Planella E, Mañosa M, Cabré E, Marín L, Gordillo J, Zabana Y, Boix J, Sáinz S, and Domènech E
- Subjects
- Adult, Biomarkers analysis, C-Reactive Protein analysis, Colectomy methods, Colon pathology, Colon surgery, Colonoscopy, Crohn Disease surgery, Female, Humans, Male, Middle Aged, Postoperative Period, Predictive Value of Tests, Preoperative Period, Prospective Studies, ROC Curve, Recurrence, Sensitivity and Specificity, Crohn Disease pathology, Feces chemistry, Leukocyte L1 Antigen Complex analysis
- Abstract
Background: Fecal calprotectin (FC) is the best noninvasive biomarker of disease activity in inflammatory bowel disease. Its correlation with endoscopic mucosal lesions could save inconvenient, expensive, and repeated endoscopic examinations in particular clinical settings., Patients and Methods: To assess the correlation between FC and the existence and severity of endoscopic postoperative recurrence (POR), a group of clinically stable outpatients with Crohn's disease for whom an ileocolonoscopy was routinely planned to assess POR were invited to collect a stool sample before starting bowel cleansing to measure FC. POR was graded by means of Rutgeerts endoscopic score., Results: One hundred nineteen ileocolonoscopies were included, 42% with endoscopic POR. FC was significantly lower in the absence of endoscopic POR and in the absence of any endoscopic lesion. The area under the receiver operating characteristic curve was 0.76 (95% confidence interval, 0.68-0.85) for the diagnosis of the absence of lesions and 0.75 (95% confidence interval, 0.66-0.84) for endoscopic POR. Better sensitivity and negative predictive value were observed when combining FC and serum C-reactive protein (CRP), leading to a sensitivity of 82%, a specificity of 53%, and negative and positive predictive values of 81% and 54%, respectively, for the prediction of endoscopic POR with a combination of FC 100 μg/g and CRP 5 mg/L cutoff values., Conclusions: FC correlates closely with endoscopic POR in clinically stable postoperative patients with Crohn's disease and, when used in combination with CRP, might save endoscopic examinations and allow for a high-grade suspicion of endoscopic POR in the long-term monitoring of these patients.
- Published
- 2016
- Full Text
- View/download PDF
46. Real-Time Non-Intrusive Assessment of Viewing Distance during Computer Use.
- Author
-
Argilés M, Cardona G, Pérez-Cabré E, Pérez-Magrané R, Morcego B, and Gispets J
- Subjects
- Adolescent, Adult, Female, Healthy Volunteers, Humans, Male, Time Factors, Young Adult, Computers, Distance Perception physiology, Internet, Ultrasonography methods
- Abstract
Purpose: To develop and test the sensitivity of an ultrasound-based sensor to assess the viewing distance of visual display terminals operators in real-time conditions., Methods: A modified ultrasound sensor was attached to a computer display to assess viewing distance in real time. Sensor functionality was tested on a sample of 20 healthy participants while they conducted four 10-minute randomly presented typical computer tasks (a match-three puzzle game, a video documentary, a task requiring participants to complete a series of sentences, and a predefined internet search)., Results: The ultrasound sensor offered good measurement repeatability. Game, text completion, and web search tasks were conducted at shorter viewing distances (54.4 cm [95% CI 51.3-57.5 cm], 54.5 cm [95% CI 51.1-58.0 cm], and 54.5 cm [95% CI 51.4-57.7 cm], respectively) than the video task (62.3 cm [95% CI 58.9-65.7 cm]). Statistically significant differences were found between the video task and the other three tasks (all p < 0.05). Range of viewing distances (from 22 to 27 cm) was similar for all tasks (F = 0.996; p = 0.413)., Conclusions: Real-time assessment of the viewing distance of computer users with a non-intrusive ultrasonic device disclosed a task-dependent pattern.
- Published
- 2016
- Full Text
- View/download PDF
47. Adhesion Molecules Associated with Female Genital Tract Infection.
- Author
-
Qualai J, Cantero J, Li LX, Carrascosa JM, Cabré E, Dern O, Sumoy L, Requena G, McSorley SJ, and Genescà M
- Subjects
- Adult, Animals, CD11c Antigen genetics, CD11c Antigen metabolism, Cell Adhesion Molecules genetics, Chlamydia Infections genetics, Chlamydia Infections veterinary, Chlamydia muridarum genetics, Disease Models, Animal, Female, HeLa Cells, Humans, Integrin alpha4beta1 genetics, Integrin alpha4beta1 metabolism, Mice, Receptors, CCR2 genetics, Receptors, CCR2 metabolism, Receptors, CCR5 genetics, Receptors, CCR5 metabolism, Receptors, CCR6 genetics, Receptors, CCR6 metabolism, Vaginosis, Bacterial genetics, Young Adult, Cell Adhesion Molecules metabolism, Chlamydia Infections metabolism, Chlamydia muridarum immunology, Gardnerella vaginalis immunology, T-Lymphocytes immunology, Vaginosis, Bacterial metabolism
- Abstract
Efforts to develop vaccines that can elicit mucosal immune responses in the female genital tract against sexually transmitted infections have been hampered by an inability to measure immune responses in these tissues. The differential expression of adhesion molecules is known to confer site-dependent homing of circulating effector T cells to mucosal tissues. Specific homing molecules have been defined that can be measured in blood as surrogate markers of local immunity (e.g. α4β7 for gut). Here we analyzed the expression pattern of adhesion molecules by circulating effector T cells following mucosal infection of the female genital tract in mice and during a symptomatic episode of vaginosis in women. While CCR2, CCR5, CXCR6 and CD11c were preferentially expressed in a mouse model of Chlamydia infection, only CCR5 and CD11c were clearly expressed by effector T cells during bacterial vaginosis in women. Other homing molecules previously suggested as required for homing to the genital mucosa such as α4β1 and α4β7 were also differentially expressed in these patients. However, CD11c expression, an integrin chain rarely analyzed in the context of T cell immunity, was the most consistently elevated in all activated effector CD8+ T cell subsets analyzed. This molecule was also induced after systemic infection in mice, suggesting that CD11c is not exclusive of genital tract infection. Still, its increase in response to genital tract disorders may represent a novel surrogate marker of mucosal immunity in women, and warrants further exploration for diagnostic and therapeutic purposes.
- Published
- 2016
- Full Text
- View/download PDF
48. Improved outcome of acute severe ulcerative colitis while using early predictors of corticosteroid failure and rescue therapies.
- Author
-
Llaó J, Naves JE, Ruiz-Cerulla A, Gordillo J, Mañosa M, Maisterra S, Cabré E, Garcia-Planella E, Guardiola J, and Domènech E
- Subjects
- Administration, Intravenous, Adult, Colectomy, Cyclosporine therapeutic use, Female, Follow-Up Studies, Humans, Infliximab therapeutic use, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Spain, Tertiary Care Centers, Treatment Failure, Adrenal Cortex Hormones therapeutic use, Colitis, Ulcerative therapy, Gastrointestinal Agents therapeutic use, Immunosuppressive Agents therapeutic use
- Abstract
Background and Aim: Intravenous corticosteroids remain the first line therapy for severe attacks of ulcerative colitis although up to 30-40% of patients do not respond to treatment. The availability of alternative therapies to colectomy and the knowledge of early predictors of response to corticosteroids should have improved the clinical outcomes of patients with severe refractory ulcerative colitis. The aim of the study is to describe the current need, way of use, and efficacy of rescue therapies, as well as colectomy rates in patients with severe ulcerative colitis flares., Methods: Between January 2005 and December 2011, all patients admitted in three referral centres for a severe ulcerative colitis flare who received intravenous corticosteroids were identified and clinical and biological data were accurately collected. Patients were followed-up until colectomy, death, or date of data collection., Results: Sixty-two flares were included. Initial efficacy of intravenous corticosteroids (mild activity or inactive disease without rescue treatment, at day 7 after starting intravenous corticosteroids) was achieved in 50% of flares, and rescue therapies were used in 27 episodes (43%). After a median follow-up of 18 months, the colectomy rate was 6.5%. Failed oral corticosteroids for the index flare were the only baseline feature that predicted the need for rescue therapy and colectomy., Conclusions: There is a marked reduction in the colectomy rate and an increased use of medical rescue therapies as compared to historical series. Patients worsening while on oral corticosteroids for a moderate flare are at high risk of rescue therapy and colectomy and, therefore, should be directly treated with rescue therapies instead of attempting intravenous corticosteroids., (Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
49. Blinking supervision in a working environment.
- Author
-
Morcego B, Argilés M, Cabrerizo M, Cardona G, Pérez R, Pérez-Cabré E, and Gispets J
- Subjects
- Dry Eye Syndromes, Humans, Iris physiology, Algorithms, Blinking physiology, Image Processing, Computer-Assisted methods, Workplace
- Abstract
The health of the ocular surface requires blinks of the eye to be frequent in order to provide moisture and to renew the tear film. However, blinking frequency has been shown to decrease in certain conditions such as when subjects are conducting tasks with high cognitive and visual demands. These conditions are becoming more common as people work or spend their leisure time in front of video display terminals. Supervision of blinking frequency in such environments is possible, thanks to the availability of computer-integrated cameras. Therefore, the aim of the present study is to develop an algorithm for the detection of eye blinks and to test it, in a number of videos captured, while subjects are conducting a variety of tasks in front of the computer. The sensitivity of the algorithm for blink detection was found to be of 87.54% (range 30% to 100%), with a mean false-positive rate of 0.19% (range 0% to 1.7%), depending on the illumination conditions during which the image was captured and other computer–user spatial configurations. The current automatic process is based on a partly modified pre-existing eye detection and image processing algorithms and consists of four stages that are aimed at eye detection, eye tracking, iris detection and segmentation, and iris height/width ratio assessment.
- Published
- 2016
- Full Text
- View/download PDF
50. Thiopurine Therapy Reduces the Incidence of Colorectal Neoplasia in Patients with Ulcerative Colitis. Data from the ENEIDA Registry.
- Author
-
Gordillo J, Cabré E, Garcia-Planella E, Ricart E, Ber-Nieto Y, Márquez L, Rodríguez-Moranta F, Ponferrada Á, Vera I, Gisbert JP, Barrio J, Esteve M, Merino O, Muñoz F, and Domènech E
- Subjects
- Adult, Aged, Aged, 80 and over, Colitis, Ulcerative complications, Colorectal Neoplasms epidemiology, Colorectal Neoplasms prevention & control, Female, Follow-Up Studies, Humans, Incidence, Logistic Models, Male, Middle Aged, Registries, Retrospective Studies, Risk Factors, Spain, Colitis, Ulcerative drug therapy, Colorectal Neoplasms etiology, Immunosuppressive Agents therapeutic use, Mercaptopurine therapeutic use
- Abstract
Background and Aims: Patients with ulcerative colitis (UC) are at increased risk of developing colorectal cancer (CRC), but recent studies suggest a lower risk than previously reported. The aim was to evaluate the incidence of dysplasia, CRC and related risk factors in UC patients from a Spanish nationwide database., Methods: All UC patients were identified and retrospectively reviewed. Clinical-epidemiological data and the finding of dysplasia and/or CRC were collected., Results: A total of 831 UC patients were included. Twenty-six cases of CRC in 26 patients and 29 cases of high-grade dysplasia (HGD) in 24 patients were found, accounting for 55 diagnoses of advanced neoplasia (AN = CRC and/or HGD) in 45 patients (33% of them within the first 8 years after UC diagnosis). The cumulative risk of AN was 2, 5.3 and 14.7% at 10, 20 and 30 years, respectively. Concomitant primary sclerosing cholangitis (odds ratio [OR] 10.90; 95% confidence interval [CI] 3.75-31.76, p < 0.001), extensive UC (OR 2.10, 95% CI 1.01-4.38, p = 0.048), UC diagnosis at an older age (OR 2.23, 95% CI 1.03-4.83, p = 0.043) and appendectomy prior to UC diagnosis (OR 2.66, 95% CI 1.06-6.71, p = 0.038) were independent risk factors for AN. Use of thiopurines (OR 0.21, 95% CI 0.06-0.74, p = 0.015) and being in a surveillance colonoscopy programme (OR 0.33; 95% CI 0.16-0.67; p = 0.002) were independent protective factors for AN., Conclusions: The risk of AN among UC patients is lower than previously reported but steadily increases from the time of UC diagnosis. The widespread use of thiopurines may have influenced this reduced incidence of UC-related neoplasias., (Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.