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The form of online teaching in the information age has become the mainstream of the construction of civil aviation professional English courses in Civics. In this paper, the digital resource module for the English course Civics for Civil Aviation Professionals is screened out by combining it with the teaching design of the Civics course for civil aviation English courses. With the help of the subtitle text selection method and the semi-supervised model of S4VM to label the teaching resources of the English course Civics, the CUMPF model is used to recommend the teaching resources of the English course Civics. Collecting and organizing the online learning behavior data of flipped classrooms to explore the influence of long and short-acting course resource design factors on the continuity of online learning, and recommending teaching resources based on the analysis results. The results of the effectiveness of the construction of the civil aviation professional English course’s Civic and political construction are analyzed from the degree of integration of the course’s Civic and political elements as well as from the four dimensions of course background, course guarantee, course implementation, and course effect, respectively. The integration degree of English course Civics resources for civil aviation majors is the best, which can reach up to 3.9315. The overall construction scores of the English course Civics are 0.907, 0.809, 0.744, and 0.768. The construction of the course implementation dimension needs to be improved, and the teaching materials of the English course Civics need to be improved in terms of writing and design. Civil aviation majors can benefit from the study’s ability to check and fill in the gaps in the Civics and Politics of English course construction.

Objective To investigate the effectiveness and safety of intravenous remifentanil patient-controlled intravenous analgesia (PCIA) regimen during the active and latency period of the first labor and its influence on plasma prostaglandin E2 (PGE2) in parturients. Methods A total of 60 full-term parturients with a single fetus giving birth vaginally in our center from January 2021 to February 2022 were enrolled in this study. The patients who were willing to receive remifentanil intravenous controlled analgesia formed group R (n=30), and those who refused analgesia formed group C (n=30). Group R received PCA of remifentanil (continuous background infusion of 0.03 μg/kg·min and bolus doses of 0.3 μg/kg with 2 min lockout period in latent phase; continuous background infusion of 0.05 μg/kg·min and bolus doses of 0.4 μg/kg with 2 min lockout period in active phase). Maternal pain score, sedation efficacy, satisfaction, and maternal and fetal adverse reactions were recorded. Neonatal Apgar score and the results of umbilical arterial blood gas analysis were recorded. The levels of PGE2 in R group were determined before and after analgesia. Results Compared to Group C, the mean NRS pain score and the lowest pain score of Group R in latent and active phases were significantly lower (P < 0.05). The overall sedation score and satisfaction score of Group R were obviously higher when compared with Group C (P < 0.05). The incidences of dizziness and drowsiness were statistically higher in the Group R (P < 0.05). No differences were seen in the neonatal Apgar score and the results of umbilical arterial blood gas analysis between the 2 groups (P>0.05). The serum PGE2 levels had no obvious change in Group R before and after analgesia (P>0.05). Conclusion According to the different intensities of labor pain in latent and active phase, appropriate adjustment of remifentanil intravenous controlled analgesia regimen can obviously mitigate maternal labor pain, without obvious maternal and fetal adverse reactions, and has no influence on maternal PGE2 levels.

Objective To test the function and evaluate the safety of the self-developed biosafety cage changing workbench. Methods According to the criteria of YY 0569-2011 "Class II Biological Safety Cabinet" and RB/T 199-2015 "Laboratory Equipment Biosafety Performance Evaluation Technical Specifications", we detected the various performance indicators of the cage changing workbench (HT-1303), which was independently developed and produced by Shenzhen Hongteng Biological Technology Co., LTD, and evaluated the safety and validity. Results The appearance integrity and stability of the main body of the biosafety cage changing workbench, the cleanliness of the working area, the velocity of the inflow airflow, the velocity of the descending airflow, the illuminance, the noise level, the airflow direction, the high-efficiency particulate air filter were at good condition, reaching the standards of level II biological safety cabinet. The airtightness of the contaminated goods recovery cabin and the sterilization chamber of utensil surface was good, but the size and quantity of the sterilized cage box need to be further improved. Conclusion The biosafety cage changing workbench developed by our team can be operated properly in whole. It can complete the replacement of individually ventilated cages in this workbench under negative pressure environment. Our workbench also can ensure the safety of operators, environment and experimental subjects.

ObjectiveTo detect the performance and use of class II biosafety cabinets in laboratories of veterinary-related research institutes.MethodsA total of 126 class II biological safety cabinetries being used by three veterinary-related reseatch institutes in Harbin were tested. The performance indicators were judged according to the test results and and analyze according to relevant standards, in order to understand the use of biological safety cabinets.ResultsThe overall pass rate of 126 biosafety cabinetries was 17.5%. The total qualified rate were 100%, 100%, 100%, 100%, 49.2%, 92.9%, 68.3%, 22.2% and 100% ,respectively in terms of the appearance of integrity, cleanliness of work area, integrity of high efficiency filter for supply and exhaust air, flow pattern, the velocity of inflow, the velocity of the downdraft, noise, illumination and alarm and interlock system of class II biosafety cabinet.ConclusionThe overall pass rate of biosafety cabinetries in some veterinary-related research institutes is low. Regular inspection, operation and maintenance management should be strengthened to eliminate biological safety hazard timely and prevent infection accidents of laboratory.

Abstract Background Noninvasive prenatal testing (NIPT) has been widely used clinically to detect fetal chromosomal aneuploidy with high accuracy rates, gradually replacing traditional serological screening. However, the application of NIPT for monogenic diseases is still in an immature stage of exploration. The detection of mutations in peripheral blood of pregnant women requires precise qualitative and quantitative techniques, which limits its application. The bioinformatic strategies based on the SNP (single nucleotide polymorphism) linkage analysis are more practical, which can be divided into two types depending on whether proband information is needed. Hidden Markov Mode (HMM) and Sequential probability ratio test (SPRT) are suitable for families with probands. In contrast, methods based on databases and population demographic information are suitable for families without probands. Methods In this study, we proposed a Spearman rank correlation analysis method to infer the fetal haplotypes based on core family information. Allele frequencies of SNPs that were used to construct parental haplotypes were calculated as sets of nonparametric variables, in contrast to their theoretical values represented by a fetal fraction (FF). The effects on the calculation of the fetal concentration of two DNA enrichment methods, multiple‐PCR amplification, and targeted hybrid capture, were compared, and the heterozygosity distribution of SNPs within pedigrees was analyzed to reveal the best conditions for the model application. Results Predictions of the paternal haplotype inheritance were in line with expectations for both DNA library construction methods, while for maternal haplotype inheritance prediction, the rates were 96.55% for method multiple‐PCR amplification and 95.8% for method targeted hybrid capture. Conclusion Positive prediction rates showed that the maternal haplotype prediction was not as accurate as paternal one, due to the large amount of maternal noise in the mother's peripheral blood. Although this model is relatively immature, it provides a new perspective for noninvasive prenatal clinical tests of monogenic diseases.

Objective To analyze the relationship between air pollutants and spontaneous abortion in Chongqing. Methods Time trend bias was controlled by time-stratified case-crossover design. The distribution lag nonlinear model was employed to study the relationship between air pollution and the number of spontaneous abortion in the main urban area of Chongqing and to control the influence of confounding factors such as meteorological factors. Based on the single pollutant model, the two-pollutant model was used to control the influence of other pollutants on correlation. Results During the study period, the average daily concentration of PM2.5, PM10, NO2 and SO2 in the air was 39.32, 63.31, 41.04 and 8.86μg/m3, respectively. All pollutants except NO2 were associated with the risk of spontaneous abortion, and all the associations reached the peak value at the lag of 3 d. For the increase of every 10μg/m3, the relative risk value was 1.069 (95%CI: 1.010~1.132), 1.046 (95%CI: 1.007~1.086) and 1.511 (95%CI: 1.148~1.989), respectively. These associations still existed in the two-pollutants model. Conclusion Short-term exposure of PM2.5, PM10 and SO2 in the ambient air may increase the risk of spontaneous abortion in Chongqing.

The statics and dynamics analyses for the steel structure of a type of single-row, three-column, five-layer lift-sliding stereo garage were carried out based on the ANSYS software and the finite element modeling. Analyses proved the safety reliability of steel structure under the extreme conditions, and the weak points of steel structure were found out. The strain monitoring program at these weak positions was designed and finished. The results of analysis were substantial agreement with the experimental results. The maintenance and design personnel could also carry on the security evaluation to the steel structure of the stereo garage through the strain monitoring data, formulate the reasonable maintenance plan, optimize the design of the structure, and improve the service life of the equipment.

A mobile laboratory integrating lidar, sun photometer and in situ instruments has been deployed to observe the aerosol spatial variability in North China Plain in May 2017. Results from the campaign are presented.

Task Performance is greatly significant in the field of education. The OECD defines Task Performance as the ability to function based on conscientiousness in the "Big Five" personality domains. People with high Task Performance tend to also have significant conscientiousness. In other words, they are more self-controlled, more responsible, and more persistent. As a result, they focus well on tasks and earn better grades. Task Performance includes self-control, responsibility, and perseverance. The study surveyed 3,647 10-year-old students and 3,621 15-year-old students in Suzhou (China) on their Task Performance by using self-assessment questionnaires, parent surveys, and teacher evaluation. The main results of the study are presented: (1) The overall status of task performance; (2) Predictive variable analysis of task performance; and (3) Task performance and life. [For part II, see EJ1324085; for part III, see EJ1324104; and for part IV, see EJ1324107.]