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Your search keyword '"Byrne, C. Ethan"' showing total 12 results
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12 results on '"Byrne, C. Ethan"'

2. Adaptable Fabrication of Vascularized Milliscale Tissues in Membrane-Free Organ Chips Manufactured with 3D Printed Molds

Author

Byrne, C. Ethan, primary, Conrad, K. Michael, additional, Martier, Ashley T., additional, Fortes, Gabrielle M., additional, Kpeli, G. Wills, additional, Olsen, Elisabet A., additional, Bralower, William, additional, Culp, Caroline C., additional, Wendell, Max, additional, Boone, Keefer A., additional, and Mondrinos, Mark J., additional

Published
2023
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3. Breast Cancer-Stromal Interactions: Adipose-Derived Stromal/Stem Cell Age and Cancer Subtype Mediated Remodeling

Author

Hamel, Katie M., primary, King, Connor T., additional, Cavalier, Maryn B., additional, Liimatta, Kara Q., additional, Rozanski, Grace L., additional, King, Timothy A., additional, Lam, Meggie, additional, Bingham, Grace C., additional, Byrne, C. Ethan, additional, Xing, Diensn, additional, Collins-Burow, Bridgette M., additional, Burow, Matthew E., additional, Belgodere, Jorge A., additional, Bratton, Melyssa R., additional, Bunnell, Bruce A., additional, and Martin, Elizabeth C., additional

Published
2022
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5. Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer

Author

King, Connor T., primary, Matossian, Margarite D., additional, Savoie, Jonathan J., additional, Nguyen, Khoa, additional, Wright, Maryl K., additional, Byrne, C. Ethan, additional, Elliott, Steven, additional, Burks, Hope E., additional, Bratton, Melyssa R., additional, Pashos, Nicholas C., additional, Bunnell, Bruce A., additional, Burow, Matthew E., additional, Collins-Burow, Bridgette M., additional, and Martin, Elizabeth C., additional

Published
2022
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9. Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

Author

Rahman, Sharif M., Campbell, Joshua M., Coates, Rachael N., Render, Katie M., Byrne, C. Ethan, Martin, Elizabeth C., Melvin, Adam T., Rahman, Sharif M., Campbell, Joshua M., Coates, Rachael N., Render, Katie M., Byrne, C. Ethan, Martin, Elizabeth C., and Melvin, Adam T.

Abstract

Breast cancer tumorigenesis and response to therapy is regulated by cancer cell interactions with the tumor microenvironment (TME). Breast cancer signaling to the surrounding TME results in a heterogeneous and diverse tumor microenvironment, which includes the production of cancer-associated fibroblasts, macrophages, adipocytes, and stem cells. The secretory profile of these cancer-associated cell types results in elevated chemokines and growth factors that promote cell survival and proliferation within the tumor. Current co-culture approaches mostly rely on transwell chambers to study intercellular signaling between adipose-derived stem cells (ASCs) and cancer cells; however, these methods are limited to endpoint measurements and lack dynamic control. In this study, a 4-channel, “flow-free” microfluidic device was developed to co-culture triple-negative MDA-MB-231 breast cancer cells and ASCs to study intercellular communication between two distinct cell types found in the TME. The device consists of two layers: a top PDMS layer with four imprinted channels coupled with a bottom agarose slab enclosed in a Plexiglas chamber. For dynamic co-culture, the device geometry contained two centered, flow-free channels, which were supplied with media from two outer flow channels via orthogonal diffusion through the agarose. Continuous fresh media was provided to the cell culture channel via passive diffusion without creating any shearing effect on the cells. The device geometry also allowed for the passive diffusion of cytokines and growth factors between the two cell types cultured in parallel channels to initiate cell-to-cell crosstalk. The device was used to show that MDA-MB-231 cells co-cultured with ASCs exhibited enhanced growth, a more aggressive morphology, and polarization toward the ASCs. The MDA-MB-231 cells were found to exhibit a greater degree of resistance to the drug paclitaxel when co-cultured with ASCs when compared to single culture studies. This microflui

Published
2020
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12. Using an in vitro fluidics approach to model the evolution of metastatic breast cancer reveals shear stress as a possible driver of genomic instability and somatic mutation

Author

Bratton, Melyssa, primary, Byrne, C Ethan, additional, Rahman, Sharif M, additional, King, Connor T, additional, Copeland, Caroline E, additional, Rhodes, Lyndsay, additional, Glotser, Ellen, additional, Ma, Peng, additional, Skripnikova, Elena, additional, Wiese, Thomas, additional, Melvin, Adam, additional, and Martin, Elizabeth, additional

Published
2019
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