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14 results on '"Byington, Robert P."'

1. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study

Author

Cochrane, Shannon K, Chen, Shyh‐Huei, Fitzgerald, Jodi D, Dodson, John A, Fielding, Roger A, King, Abby C, McDermott, Mary M, Manini, Todd M, Marsh, Anthony P, Newman, Anne B, Pahor, Marco, Tudor‐Locke, Catrine, Ambrosius, Walter T, Buford, Thomas W, Espeland, Mark A, Applegate, William, Beavers, Daniel P, Byington, Robert P, Cook, Delilah, Furberg, Curt D, Harvin, Lea N, Henkin, Leora, Hepler, John, Hsu, Fang‐Chi, Lovato, Laura, Roberson, Wesley, Rushing, Julia, Rushing, Scott, Stowe, Cynthia L, Walkup, Michael P, Hire, Don, Rejeski, W Jack, Katula, Jeffrey A, Brubaker, Peter H, Mihalko, Shannon L, Jennings, Janine M, Pierce, June J, Romashkan, Sergei, Patel, Kushang V, Bonds, Denise, Spring, Bonnie, Hauser, Joshua, Kerwin, Diana, Domanchuk, Kathryn, Graff, Rex, Rego, Alvito, Blair, Steven N, Myers, Valerie H, Monce, Ron, Britt, Nathan E, Harris, Melissa Nauta, McGucken, Ami Parks, Rodarte, Ruben, Millet, Heidi K, Butitta, Ben P, Donatto, Sheletta G, Cocreham, Shannon H, Castro, Cynthia M, Haskell, William L, Stafford, Randall S, Pruitt, Leslie A, Berra, Kathy, Yank, Veronica, Anton, Stephen D, Nayfield, Susan, Marsiske, Michael, Sandesara, Bhanuprasad D, Knaggs, Jeffrey D, Lorow, Megan S, Marena, William C, Korytov, Irina, Morris, Holly L, Fitch, Margo, Singletary, Floris F, Causer, Jackie, Radcliff, Katie A, Studenski, Stephanie A, Goodpaster, Bret H, Glynn, Nancy W, Lopez, Oscar, Nadkarni, Neelesh K, Williams, Kathy, Newman, Mark A, Grove, George, Bonk, Janet T, Rush, Jennifer, Kost, Piera, Ives, Diane G, Brinkley, Tina E, Demons, Jamehl S, Sink, Kaycee M, Kennedy, Kimberly, Shertzer‐Skinner, Rachel, Wrights, Abbie, Fries, Rose, Barr, Deborah, Axtell, Robert S, Kashaf, Susan S, de Rekeneire, Nathalie, and McGloin, Joanne M

Subjects
Aging, Cardiovascular, Prevention, Clinical Research, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Actigraphy, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Exercise, Exercise Therapy, Female, Fitness Trackers, Geriatric Assessment, Health Knowledge, Attitudes, Practice, Humans, Incidence, Male, Mobility Limitation, Patient Education as Topic, Predictive Value of Tests, Prognosis, Protective Factors, Risk Factors, Risk Reduction Behavior, Time Factors, United States, LIFE Study Research Group, accelerometry, aging, cardiovascular, physical activity, Cardiorespiratory Medicine and Haematology
Abstract

BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS:Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. CONCLUSIONS:Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score >10 on the Short Physical Performance Battery) both using baseline and longitudinal data. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01072500.

Published
2017

2. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

Author

Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P J, Brown, Morris, Brugts, Jasper J, Bulpitt, Christopher J, Byington, Robert P, Cushman, William C, Cutler, Jeffrey, Devereaux, Richard B, Dwyer, Jamie P, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Gianpaolo, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang, Chalmers, John, Davis, Barry R, Pepine, Carl J, and Teo, Koon K

Published
2021
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3. Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Author

Reith, Christina, Preiss, David, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Harper, Charlie, Holland, Lisa, Wilson, Kate, Roddick, Alistair J, Cannon, Christopher P, Clarke, Robert, Colhoun, Helen M, Durrington, Paul N, Goto, Shinya, Hitman, Graham A, Hovingh, G Kees, Jukema, J Wouter, Koenig, Wolfgang, Marschner, Ian, Mihaylova, Borislava, Newman, Connie, Probsfield, Jeffrey L, Ridker, Paul M, Sabatine, Marc S, Sattar, Naveed, Schwartz, Gregory G, Tavazzi, Luigi, Tonkin, Andrew, Trompet, Stella, White, Harvey, Yusuf, Salim, Armitage, Jane, Keech, Anthony, Simes, John, Collins, Rory, Baigent, Colin, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, O'Connell, Rachel, Amarenco, Pierre, Arashi, Hiroyuki, Barter, Philip, Betteridge, D John, Blazing, Michael, Blauw, Gerard J, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Bulbulia, Richard, Byington, Robert, Clearfield, Michael, Cobbe, Stuart, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fuller, John, Furberg, Curt, Glynn, Robert, Goldbourt, Uri, Gordon, David, Gotto, Antonio, Jr, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Haynes, Richard, Holdaas, Hallvard, Hopewell, Jemma, Jardine, Alan, Kastelein, John JP, Kean, Sharon, Kearney, Patricia, Kitas, George, Kjekshus, John, Knatterud, Genell, Knopp, Robert H, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Robertson, Michele, Sacks, Frank, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shepherd, James, Simpson, Lara, Sleight, Peter, Smeeth, Liam, Tobert, Jonathan, Tognoni, Gianni, Varigos, John, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Yamaguchi, Junichi, Young, Robin, and Zannad, Faiez

Abstract

Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, randomised, double-blind trials of statin therapy.

Published
2024
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4. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

Author

Gill, Thomas, Fragoso, Carlos, Fielding, Roger, Hauser, Michelle E., Pahor, Marco, Guralnik, Jack M., Leeuwenburgh, Christiaan, Caudle, Connie, Crump, Lauren, Holmes, Latonia, Lee, Jocelyn, Lu, Ching-ju, Miller, Michael E., Espeland, Mark A., Ambrosius, Walter T., Applegate, William, Beavers, Daniel P., Byington, Robert P., Cook, Delilah, Furberg, Curt D., Harvin, Lea N., Henkin, Leora, Hepler, Med John, Hsu, Fang-Chi, Lovato, Laura, Roberson, Wesley, Rushing, Julia, Rushing, Scott, Stowe, Cynthia L., Walkup, Michael P., Hire, Don, Rejeski, W. Jack, Katula, Jeffrey A., Brubaker, Peter H., Mihalko, Shannon L., Jennings, Janine M., Hadley, Evan C., Romashkan, Sergei, Patel, Kushang V., Bonds, Denise, McDermott, Mary M., Spring, Bonnie, Hauser, Joshua, Kerwin, Diana, Domanchuk, Kathryn, Graff, Rex, Rego, Alvito, Church, Timothy S., Blair, Steven N., Myers, Valerie H., Monce, Ron, Britt, Nathan E., Harris, Melissa Nauta, McGucken, Ami Parks, Rodarte, Ruben, Millet, Heidi K., Tudor-Locke, Catrine, Butitta, Ben P., Donatto, Sheletta G., Cocreham, Shannon H., King, Abby C., Castro, Cynthia M., Haskell, William L., Stafford, Randall S., Pruitt, Leslie A., Berra, Kathy, Yank, Veronica, Fielding, Roger A., Nelson, Miriam E., Folta, Sara C., Phillips, Edward M., Liu, Christine K., McDavitt, Erica C., Reid, Kieran F., Kirn, Dylan R., Pasha, Evan P., Kim, Won S., Beard, Vince E., Tsiroyannis, Eleni X., Hau, Cynthia, Manini, Todd M., Anton, Stephen D., Nayfield, Susan, Buford, Thomas W., Marsiske, Michael, Sandesara, Bhanuprasad D., Knaggs, Jeffrey D., Lorow, Megan S., Marena, William C., Korytov, Irina, Morris, Holly L., Fitch, Margo, Singletary, Floris F., Causer, Jackie, Radcliff, Katie A., Newman, Anne B., Studenski, Stephanie A., Goodpaster, Bret H., Glynn, Nancy W., Lopez, Oscar, Nadkarni, Neelesh K., Williams, Kathy, Newman, Mark A., Grove, George, Bonk, Janet T., Rush, Jennifer, Kost, Piera, Ives, Diane G., Kritchevsky, Stephen B., Marsh, Anthony P., Brinkley, Tina E., Demons, Jamehl S., Sink, Kaycee M., Kennedy, Kimberly, Shertzer-Skinner, Rachel, Wrights, Abbie, Fries, Rose, Barr, Deborah, Gill, Thomas M., Axtell, Robert S., Kashaf, Susan S., de Rekeneire, Nathalie, McGloin, Joanne M., Wu, Karen C., Shepard, Denise M., Fennelly, Barbara, Iannone, Lynne P., Mautner, Raeleen, Barnett, Theresa Sweeney, Halpin, Sean N., Brennan, Matthew J., Bugaj, Julie A., Zenoni, Maria A., Mignosa, Bridget M., Williamson, Jeff, Hendrie, Hugh C., Rapp, Stephen R., Verghese, Joe, Woolard, Nancy, Espeland, Mark, Jennings, Janine, Wilson, Valerie K., Pepine, Carl J., Ariet, Mario, Handberg, Eileen, Deluca, Daniel, Hill, James, Szady, Anita, Chupp, Geoffrey L., Flynn, Gail M., Hankinson, John L., Vaz Fragoso, Carlos A., Groessl, Erik J., Kaplan, Robert M., Aubertin-Leheudre, Mylène, Anton, Stephen, Newman, Ann, Church, Tim, Conroy, David, and Botoseneanu, Anda

Published
2017
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5. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death:an individual participant-level data meta-analysis

Author

Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W., Beckett, Nigel S., Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P.J., Brown, Morris, Brugts, Jasper J., Bulpitt, Christopher J., Byington, Robert P., Cushman, William C., Cutler, Jeffrey, Devereaux, Richard B., Dwyer, Jamie P., Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K., Holman, Rury R., Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E., Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B., Lievre, Michel, Lindholm, Lars H., Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H., Nissen, Steven, Ogawa, Hiroshi, Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W., Beckett, Nigel S., Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P.J., Brown, Morris, Brugts, Jasper J., Bulpitt, Christopher J., Byington, Robert P., Cushman, William C., Cutler, Jeffrey, Devereaux, Richard B., Dwyer, Jamie P., Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K., Holman, Rury R., Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E., Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B., Lievre, Michel, Lindholm, Lars H., Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H., Nissen, Steven, and Ogawa, Hiroshi

Abstract

Background: The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-pressure-lowering treatment on the risk of major cardiovascular events in groups of patients stratified by age and blood pressure at baseline. Methods: We did a meta-analysis using individual participant-level data from randomised controlled trials of pharmacological blood-pressure-lowering versus placebo or other classes of blood-pressure-lowering medications, or between more versus less intensive treatment strategies, which had at least 1000 persons-years of follow-up in each treatment group. Participants with previous history of heart failure were excluded. Data were obtained from the Blood Pressure Lowering Treatment Triallists' Collaboration. We pooled the data and categorised participants into baseline age groups (<55 years, 55–64 years, 65–74 years, 75–84 years, and ≥85 years) and blood pressure categories (in 10 mm Hg increments from <120 mm Hg to ≥170 mm Hg systolic blood pressure and from <70 mm Hg to ≥110 mm Hg diastolic). We used a fixed effects one-stage approach and applied Cox proportional hazard models, stratified by trial, to analyse the data. The primary outcome was defined as either a composite of fatal or non-fatal stroke, fatal or non-fatal myocardial infarction or ischaemic heart disease, or heart failure causing death or requiring hospital admission. Findings: We included data from 358 707 participants from 51 randomised clinical trials. The age of participants at randomisation ranged from 21 years to 105 years (median 65 years [IQR 59–75]), with 42 960 (12·0%) participants younger than 55 years, 128 437 (35·8%) aged 55–64 years, 128 506 (35·8%) 65–74 years, 54 016 (15·1%) 75–84 years, and 4788 (1·3%) 85 years and older. The hazard ratios for the risk of major cardiovascular events per 5 mm

Published
2021

6. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Author

Rahimi, Kazem, primary, Bidel, Zeinab, additional, Nazarzadeh, Milad, additional, Copland, Emma, additional, Canoy, Dexter, additional, Ramakrishnan, Rema, additional, Pinho-Gomes, Ana-Catarina, additional, Woodward, Mark, additional, Adler, Amanda, additional, Agodoa, Larry, additional, Algra, Ale, additional, Asselbergs, Folkert W, additional, Beckett, Nigel S, additional, Berge, Eivind, additional, Black, Henry, additional, Brouwers, Frank P J, additional, Brown, Morris, additional, Bulpitt, Christopher J, additional, Byington, Robert P, additional, Cushman, William C, additional, Cutler, Jeffrey, additional, Devereaux, Richard B, additional, Dwyer, Jamie, additional, Estacio, Ray, additional, Fagard, Robert, additional, Fox, Kim, additional, Fukui, Tsuguya, additional, Gupta, Ajay K, additional, Holman, Rury R, additional, Imai, Yutaka, additional, Ishii, Masao, additional, Julius, Stevo, additional, Kanno, Yoshihiko, additional, Kjeldsen, Sverre E, additional, Kostis, John, additional, Kuramoto, Kizuku, additional, Lanke, Jan, additional, Lewis, Edmund, additional, Lewis, Julia B, additional, Lievre, Michel, additional, Lindholm, Lars H, additional, Lueders, Stephan, additional, MacMahon, Stephen, additional, Mancia, Giuseppe, additional, Matsuzaki, Masunori, additional, Mehlum, Maria H, additional, Nissen, Steven, additional, Ogawa, Hiroshi, additional, Ogihara, Toshio, additional, Ohkubo, Takayoshi, additional, Palmer, Christopher R, additional, Patel, Anushka, additional, Pfeffer, Marc Allan, additional, Pitt, Bertram, additional, Poulter, Neil R, additional, Rakugi, Hiromi, additional, Reboldi, Gianpaolo, additional, Reid, Christopher, additional, Remuzzi, Giuseppe, additional, Ruggenenti, Piero, additional, Saruta, Takao, additional, Schrader, Joachim, additional, Schrier, Robert, additional, Sever, Peter, additional, Sleight, Peter, additional, Staessen, Jan A, additional, Suzuki, Hiromichi, additional, Thijs, Lutgarde, additional, Ueshima, Kenji, additional, Umemoto, Seiji, additional, van Gilst, Wiek H, additional, Verdecchia, Paolo, additional, Wachtell, Kristian, additional, Whelton, Paul, additional, Wing, Lindon, additional, Yui, Yoshiki, additional, Yusuf, Salim, additional, Zanchetti, Alberto, additional, Zhang, Zhen-Yu, additional, Anderson, Craig, additional, Baigent, Colin, additional, Brenner, Barry Morton, additional, Collins, Rory, additional, de Zeeuw, Dick, additional, Lubsen, Jacobus, additional, Malacco, Ettore, additional, Neal, Bruce, additional, Perkovic, Vlado, additional, Rodgers, Anthony, additional, Rothwell, Peter, additional, Salimi-Khorshidi, Gholamreza, additional, Sundström, Johan, additional, Turnbull, Fiona, additional, Viberti, Giancarlo, additional, Wang, Jiguang, additional, Chalmers, John, additional, Teo, Koon K, additional, Pepine, Carl J, additional, and Davis, Barry R, additional

Published
2021
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7. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Author

Reith, Christina, Baigent, Colin, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Holland, Lisa, Wilson, Kate, Armitage, Jane, Harper, Charlie, Preiss, David, Roddick, Alistair, Keech, Anthony, Simes, John, Collins, Rory, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, Mihaylova, Borislava, O'Connell, Rachel, Amarenco, Pierre, Barter, Philip, Betteridge (deceased), D John, Blazing, Michael, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Cannon, Christopher P, Clearfield, Michael, Cobbe, Stuart, Colhoun, Helen M, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul N, Fellström, Bengt, Ford, Ian, Franzosi, Maria Grazia, Fuller (deceased), John, Furberg, Curt, Glynn, Robert, Gordon, David, Gotto Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Hitman, Graham A, Holdaas (deceased), Hallvard, Jardine, Alan, Jukema, J Wouter, Kastelein, John JP, Kean, Sharon, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert H, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Ridker, Paul M, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick W, Sever, Peter, Shaw (deceased), John, Shepherd (deceased), James, Simpson, Lara, Sleight (deceased), Peter, Tavazzi, Luigi, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Young, Robin, Yusuf, Salim, Zannad, Faiez, Arashi, Hiroyuki, Byington, Robert, Clarke, Robert, Flather, Marcus, Goldbourt, Uri, Goto, Shinya, Hopewell, Jemma, Hovingh, Kees, Kearney, Patricia, Kitas, George, Newman, Connie, Sabatine, Marc S, Schwartz, Greg, Smeeth, Liam, Tobert, Jonathan, Varigos, John, and Yamaguchi, Junichi

Abstract

Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin therapy.

Published
2022
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8. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Author

Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Brouwers, Frank P J, Brown, Morris, Bulpitt, Christopher J, Byington, Robert P, Chalmers, John, Cushman, William C, Cutler, Jeffrey, Davis, Barry R, Devereaux, Richard B, Dwyer, Jamie, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pepine, Carl J, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Giuseppe, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, and Wang, Jiguang

Abstract

The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure.

Published
2021
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9. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

Author

Aubertin-Leheudre, Mylène, primary, Anton, Stephen, additional, Beavers, Daniel P., additional, Manini, Todd M., additional, Fielding, Roger, additional, Newman, Ann, additional, Church, Tim, additional, Kritchevsky, Stephen B., additional, Conroy, David, additional, McDermott, Mary M., additional, Botoseneanu, Anda, additional, Hauser, Michelle E., additional, Pahor, Marco, additional, Gill, Thomas, additional, Fragoso, Carlos, additional, Guralnik, Jack M., additional, Leeuwenburgh, Christiaan, additional, Caudle, Connie, additional, Crump, Lauren, additional, Holmes, Latonia, additional, Lee, Jocelyn, additional, Lu, Ching-ju, additional, Miller, Michael E., additional, Espeland, Mark A., additional, Ambrosius, Walter T., additional, Applegate, William, additional, Byington, Robert P., additional, Cook, Delilah, additional, Furberg, Curt D., additional, Harvin, Lea N., additional, Henkin, Leora, additional, Hepler, Med John, additional, Hsu, Fang-Chi, additional, Lovato, Laura, additional, Roberson, Wesley, additional, Rushing, Julia, additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Walkup, Michael P., additional, Hire, Don, additional, Rejeski, W. Jack, additional, Katula, Jeffrey A., additional, Brubaker, Peter H., additional, Mihalko, Shannon L., additional, Jennings, Janine M., additional, Hadley, Evan C., additional, Romashkan, Sergei, additional, Patel, Kushang V., additional, Bonds, Denise, additional, Spring, Bonnie, additional, Hauser, Joshua, additional, Kerwin, Diana, additional, Domanchuk, Kathryn, additional, Graff, Rex, additional, Rego, Alvito, additional, Church, Timothy S., additional, Blair, Steven N., additional, Myers, Valerie H., additional, Monce, Ron, additional, Britt, Nathan E., additional, Harris, Melissa Nauta, additional, McGucken, Ami Parks, additional, Rodarte, Ruben, additional, Millet, Heidi K., additional, Tudor-Locke, Catrine, additional, Butitta, Ben P., additional, Donatto, Sheletta G., additional, Cocreham, Shannon H., additional, King, Abby C., additional, Castro, Cynthia M., additional, Haskell, William L., additional, Stafford, Randall S., additional, Pruitt, Leslie A., additional, Berra, Kathy, additional, Yank, Veronica, additional, Fielding, Roger A., additional, Nelson, Miriam E., additional, Folta, Sara C., additional, Phillips, Edward M., additional, Liu, Christine K., additional, McDavitt, Erica C., additional, Reid, Kieran F., additional, Kirn, Dylan R., additional, Pasha, Evan P., additional, Kim, Won S., additional, Beard, Vince E., additional, Tsiroyannis, Eleni X., additional, Hau, Cynthia, additional, Anton, Stephen D., additional, Nayfield, Susan, additional, Buford, Thomas W., additional, Marsiske, Michael, additional, Sandesara, Bhanuprasad D., additional, Knaggs, Jeffrey D., additional, Lorow, Megan S., additional, Marena, William C., additional, Korytov, Irina, additional, Morris, Holly L., additional, Fitch, Margo, additional, Singletary, Floris F., additional, Causer, Jackie, additional, Radcliff, Katie A., additional, Newman, Anne B., additional, Studenski, Stephanie A., additional, Goodpaster, Bret H., additional, Glynn, Nancy W., additional, Lopez, Oscar, additional, Nadkarni, Neelesh K., additional, Williams, Kathy, additional, Newman, Mark A., additional, Grove, George, additional, Bonk, Janet T., additional, Rush, Jennifer, additional, Kost, Piera, additional, Ives, Diane G., additional, Marsh, Anthony P., additional, Brinkley, Tina E., additional, Demons, Jamehl S., additional, Sink, Kaycee M., additional, Kennedy, Kimberly, additional, Shertzer-Skinner, Rachel, additional, Wrights, Abbie, additional, Fries, Rose, additional, Barr, Deborah, additional, Gill, Thomas M., additional, Axtell, Robert S., additional, Kashaf, Susan S., additional, de Rekeneire, Nathalie, additional, McGloin, Joanne M., additional, Wu, Karen C., additional, Shepard, Denise M., additional, Fennelly, Barbara, additional, Iannone, Lynne P., additional, Mautner, Raeleen, additional, Barnett, Theresa Sweeney, additional, Halpin, Sean N., additional, Brennan, Matthew J., additional, Bugaj, Julie A., additional, Zenoni, Maria A., additional, Mignosa, Bridget M., additional, Williamson, Jeff, additional, Hendrie, Hugh C., additional, Rapp, Stephen R., additional, Verghese, Joe, additional, Woolard, Nancy, additional, Espeland, Mark, additional, Jennings, Janine, additional, Wilson, Valerie K., additional, Pepine, Carl J., additional, Ariet, Mario, additional, Handberg, Eileen, additional, Deluca, Daniel, additional, Hill, James, additional, Szady, Anita, additional, Chupp, Geoffrey L., additional, Flynn, Gail M., additional, Hankinson, John L., additional, Vaz Fragoso, Carlos A., additional, Groessl, Erik J., additional, and Kaplan, Robert M., additional

Published
2017
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10. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Author

Layne, Andrew S., primary, Hsu, Fang-Chi, additional, Blair, Steven N., additional, Chen, Shyh-Huei, additional, Dungan, Jennifer, additional, Fielding, Roger A., additional, Glynn, Nancy W., additional, Hajduk, Alexandra M., additional, King, Abby C., additional, Manini, Todd M., additional, Marsh, Anthony P., additional, Pahor, Marco, additional, Pellegrini, Christine A., additional, Buford, Thomas W., additional, Guralnik, Jack M., additional, Leeuwenburgh, Christiaan, additional, Caudle, Connie, additional, Crump, Lauren, additional, Holmes, Latonia, additional, Lee, Jocelyn, additional, Lu, Ching-ju, additional, Miller, Michael E., additional, Espeland, Mark A., additional, Ambrosius, Walter T., additional, Applegate, William, additional, Beavers, Daniel P., additional, Byington, Robert P., additional, Cook, Delilah, additional, Furberg, Curt D., additional, Harvin, Lea N., additional, Henkin, Leora, additional, Hepler, John, additional, Lovato, Laura, additional, Roberson, Wesley, additional, Rushing, Julia, additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Walkup, Michael P., additional, Hire, Don, additional, Rejeski, W. Jack, additional, Katula, Jeffrey A., additional, Brubaker, Peter H., additional, Mihalko, Shannon L., additional, Jennings, Janine M., additional, Hadley, Evan C., additional, Romashkan, Sergei, additional, Patel, Kushang V., additional, Bonds, Denise, additional, McDermott, Mary M., additional, Spring, Bonnie, additional, Hauser, Joshua, additional, Kerwin, Diana, additional, Domanchuk, Kathryn, additional, Graff, Rex, additional, Rego, Alvito, additional, Church, Timothy S., additional, Myers, Valerie H., additional, Monce, Ron, additional, Britt, Nathan E., additional, Harris, Melissa Nauta, additional, McGucken, Ami Parks, additional, Rodarte, Ruben, additional, Millet, Heidi K., additional, Tudor-Locke, Catrine, additional, Butitta, Ben P., additional, Donatto, Sheletta G., additional, Cocreham, Shannon H., additional, Castro, Cynthia M., additional, Haskell, William L., additional, Stafford, Randall S., additional, Pruitt, Leslie A., additional, Berra, Kathy, additional, Yank, Veronica, additional, Nelson, Miriam E., additional, Folta, Sara C., additional, Phillips, Edward M., additional, Liu, Christine K., additional, McDavitt, Erica C., additional, Reid, Kieran F., additional, Kim, Won S., additional, Beard, Vince E., additional, Anton, Stephen D., additional, Nayfield, Susan, additional, Marsiske, Michael, additional, Sandesara, Bhanuprasad D., additional, Knaggs, Jeffrey D., additional, Lorow, Megan S., additional, Marena, William C., additional, Korytov, Irina, additional, Morris, Holly L., additional, Fitch, Margo, additional, Singletary, Floris F., additional, Causer, Jackie, additional, Radcliff, Katie A., additional, Newman, Anne B., additional, Studenski, Stephanie A., additional, Goodpaster, Bret H., additional, Lopez, Oscar, additional, Nadkarni, Neelesh K., additional, Williams, Kathy, additional, Newman, Mark A., additional, Grove, George, additional, Bonk, Janet T., additional, Rush, Jennifer, additional, Kost, Piera, additional, Ives, Diane G., additional, Kritchevsky, Stephen B., additional, Brinkley, Tina E., additional, Demons, Jamehl S., additional, Sink, Kaycee M., additional, Kennedy, Kimberly, additional, Shertzer-Skinner, Rachel, additional, Wrights, Abbie, additional, Fries, Rose, additional, Barr, Deborah, additional, Gill, Thomas M., additional, Axtell, Robert S., additional, Kashaf, Susan S., additional, de Rekeneire, Nathalie, additional, McGloin, Joanne M., additional, Wu, Karen C., additional, Shepard, Denise M., additional, Fennelly, Barbara, additional, Iannone, Lynne P., additional, Mautner, Raeleen, additional, Barnett, Theresa Sweeney, additional, Halpin, Sean N., additional, Brennan, Matthew J., additional, Bugaj, Julie A., additional, Zenoni, Maria A., additional, Mignosa, Bridget M., additional, Williamson, Jeff, additional, Hendrie, Hugh C., additional, Rapp, Stephen R., additional, Verghese, Joe, additional, Woolard, Nancy, additional, Espeland, Mark, additional, Jennings, Janine, additional, Pepine, Carl J., additional, Ariet, Mario, additional, Handberg, Eileen, additional, Deluca, Daniel, additional, Hill, James, additional, Szady, Anita, additional, Chupp, Geoffrey L., additional, Flynn, Gail M., additional, Hankinson, John L., additional, Vaz Fragoso, Carlos A., additional, Groessl, Erik J., additional, and Kaplan, Robert M., additional

Published
2017
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12. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

Author

Armitage, Jane, Baigent, Colin, Barnes, Elizabeth, Betteridge, D John, Blackwell, Lisa, Blazing, Michael, Bowman, Louise, Braunwald, Eugene, Byington, Robert, Cannon, Christopher, Clearfield, Michael, Colhoun, Helen, Collins, Rory, Dahlöf, Björn, Davies, Kelly, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul, Emberson, Jonathan, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fulcher, Jordan, Fuller, John, Furberg, Curt, Gordon, David, Goto, Shinya, Gotto, Antonio, Halls, Heather, Harper, Charlie, Hawkins, C Morton, Herrington, Will, Hitman, Graham, Holdaas, Hallvard, Holland, Lisa, Jardine, Alan, Jukema, J Wouter, Kastelein, John, Kean, Sharon, Keech, Anthony, Kirby, Adrienne, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin J, LaRosa, John, Lonn, Eva, MacFarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Mihaylova, Borislava, Moyé, Lemuel, Murphy, Sabina, Nakamura, Haruo, Neil, Andrew, Newman, Connie, O'Connell, Rachel, Packard, Chris, Parish, Sarah, Pedersen, Terje, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Preiss, David, Reith, Christina, Ridker, Paul, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shear, Charles, Simes, John, Sleight, Peter, Spata, Enti, Tavazzi, Luigi, Tobert, Jonathan, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Varigos, John, Wanner, Christoph, Wedel, Hans, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wilson, Kate, Young, Robin, Yusuf, Salim, and Zannad, Faiez

Abstract

Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages.

Published
2019
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14. Association of Fenofibrate Therapy With Long-term Cardiovascular Risk in Statin-Treated Patients With Type 2 Diabetes.

Author

Elam, Marshall B., Ginsberg, Henry N., Lovato, Laura C., Corson, Marshall, Largay, Joseph, Leiter, Lawrence A., Lopez, Carlos, O'Connor, Patrick J., Sweeney, Mary Ellen, Weiss, Daniel, Friedewald, William T., Buse, John B., Gerstein, Hertzel C., Probstfield, Jeffrey, Grimm, Richard, Ismail-Beigi, Faramarz, Goff Jr., David C., Fleg, Jerome L., Rosenberg, Yves, and Byington, Robert P.

Published
2017
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