46 results on '"Bruzek, Amy"'
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2. Complications of the Occult Spinal Dysraphisms
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Bruzek, Amy K., Maher, Cormac O., Tubbs, R. Shane, editor, Oskouian, Rod J., editor, Blount, Jeffrey P., editor, and Oakes, W. Jerry, editor
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- 2019
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3. Everolimus improves the efficacy of dasatinib in PDGFR[alpha]-driven glioma
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Miklja, Zachary, Yadav, Viveka Nand, Cartaxo, Rodrigo T., Siada, Ruby, Thomas, Chase C., Cummings, Jessica R., Mullan, Brendan, Stallard, Stefanie, Paul, Alyssa, Bruzek, Amy K., Wierzbicki, Kyle, Yang, Tao, Garcia, Taylor, Wolfe, Ian, Leonard, Marcia, Robertson, Patricia L., Garton, Hugh J.L., Wahl, Daniel R., Parmar, Hemant, Sarkaria, Jann N., Kline, Cassie, Mueller, Sabine, Nicolaides, Theodore, Glasser, Chana, Leary, Sarah E.S., Venneti, Sriram, Kumar-Sinha, Chandan, Chinnaiyan, Arul M., Mody, Rajen, Pai, Manjunath P., Phoenix, Timothy N., Marini, Bernard L., and Koschmann, Carl
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Gliomas -- Drug therapy ,Tumor proteins -- Drug therapy ,Child health ,Lenvatinib ,Antineoplastic agents ,Health care industry - Abstract
Pediatric and adult high-grade gliomas (HGGs) frequently harbor PDGFR[alpha] alterations. We hypothesized that cotreatment with everolimus may improve the efficacy of dasatinib in PDGFR[alpha]-driven glioma through combinatorial synergism and increased tumor accumulation of dasatinib. We performed dose-response, synergism, P-glycoprotein inhibition, and pharmacokinetic studies in in vitro and in vivo human and mouse models of HGG. Six patients with recurrent PDGFR[alpha]-driven glioma were treated with dasatinib and everolimus. We found that dasatinib effectively inhibited the proliferation of mouse and human primary HGG cells with a variety of PDGFR[alpha] alterations. Dasatinib exhibited synergy with everolimus in the treatment of HGG cells at low nanomolar concentrations of both agents, with a reduction in mTOR signaling that persisted after dasatinib treatment alone. Prolonged exposure to everolimus significantly improved the CNS retention of dasatinib and extended the survival of PPK tumor-bearing mice (mutant TP53, mutant PDGFR[alpha], H3K27M). Six pediatric patients with glioma tolerated this combination without significant adverse events, and 4 patients with recurrent disease (n = 4) had a median overall survival of 8.5 months. Our results show that the efficacy of dasatinib treatment of PDGFR[alpha]-driven HGG was enhanced with everolimus and suggest a promising route for improving targeted therapy for this patient population., Introduction High-grade gliomas (HGGs) are common and aggressive pediatric and adult brain tumors. The median overall survival (OS) of adult patients diagnosed with glioblastoma (GBM), grade IV glioma, is 12.6 [...]
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- 2020
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4. BIOM-58. ZERO-WASTE MOLECULAR DIAGNOSTICS FROM BIOPSY NEEDLE WASHES
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Wadden, Jack, primary, John, Vishal, additional, Niculcea, Michael, additional, Kong, Seongbae, additional, Aittaleb, Rayan, additional, Cartaxo, Rodrigo, additional, Verbal, Kait, additional, Bruzek, Amy, additional, Magge, Suresh, additional, Yadavilli, Sridevi, additional, Erez, Nir, additional, Furth, Noa, additional, Shema, Efrat, additional, Marapudi, Neena, additional, Heth, Jason, additional, Al-holou, Wajd, additional, Garton, Hugh, additional, Nazarian, Javad, additional, and Koschmann, Carl, additional
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- 2023
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5. Correction to: Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma
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Wierzbicki, Kyle, Ravi, Karthik, Franson, Andrea, Bruzek, Amy, Cantor, Evan, Harris, Micah, Homan, Morgan J., Marini, Bernard L., Kawakibi, Abed Rahman, Ravindran, Ramya, Teodoro, Rodrigo, Yadav, Viveka Nand, and Koschmann, Carl
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- 2020
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6. Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma
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Wierzbicki, Kyle, Ravi, Karthik, Franson, Andrea, Bruzek, Amy, Cantor, Evan, Harris, Micah, Homan, Morgan J., Marini, Bernard L., Kawakibi, Abed Rahman, Ravindran, Ramya, Teodoro, Rodrigo, Yadav, Viveka Nand, and Koschmann, Carl
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- 2020
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7. Medulloblastoma
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Bruzek, Amy K., primary, Hervey-Jumper, Shawn L., additional, and Muraszko, Karin M., additional
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- 2019
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8. Middle Fossa Arachnoid Cyst
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Bruzek, Amy K., primary and Maher, Cormac O., additional
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- 2019
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9. Supplementary Table S3A and S3B from Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma
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Bruzek, Amy K., primary, Ravi, Karthik, primary, Muruganand, Ashwath, primary, Wadden, Jack, primary, Babila, Clarissa May, primary, Cantor, Evan, primary, Tunkle, Leo, primary, Wierzbicki, Kyle, primary, Stallard, Stefanie, primary, Dickson, Robert P., primary, Wolfe, Ian, primary, Mody, Rajen, primary, Schwartz, Jonathan, primary, Franson, Andrea, primary, Robertson, Patricia L., primary, Muraszko, Karin M., primary, Maher, Cormac O., primary, Garton, Hugh J.L., primary, Qin, Tingtin, primary, and Koschmann, Carl, primary
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- 2023
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10. Supplementary Data from Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma
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Bruzek, Amy K., primary, Ravi, Karthik, primary, Muruganand, Ashwath, primary, Wadden, Jack, primary, Babila, Clarissa May, primary, Cantor, Evan, primary, Tunkle, Leo, primary, Wierzbicki, Kyle, primary, Stallard, Stefanie, primary, Dickson, Robert P., primary, Wolfe, Ian, primary, Mody, Rajen, primary, Schwartz, Jonathan, primary, Franson, Andrea, primary, Robertson, Patricia L., primary, Muraszko, Karin M., primary, Maher, Cormac O., primary, Garton, Hugh J.L., primary, Qin, Tingtin, primary, and Koschmann, Carl, primary
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- 2023
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11. 163 - Central Nervous System Embryonal Tumors
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Pekmezci, Melike, Bruzek, Amy K., Altshuler, David B., Muraszko, Karin, and Hervey-Jumper, Shawn L.
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- 2023
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12. CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response
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Stallard, Stefanie, Savelieff, Masha G., Wierzbicki, Kyle, Mullan, Brendan, Miklja, Zachary, Bruzek, Amy, Garcia, Taylor, Siada, Ruby, Anderson, Bailey, Singer, Benjamin H., Hashizume, Rintaro, Carcaboso, Angel M., McMurray, Kaitlin Q., Heth, Jason, Muraszko, Karin, Robertson, Patricia L., Mody, Rajen, Venneti, Sriram, Garton, Hugh, and Koschmann, Carl
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- 2018
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13. Robot-Assisted Minimally Invasive Sacroiliac Joint Fusion for Sacroiliac Joint Dysfunction: 2-Dimensional Operative Video
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Holste, Katherine G., primary, Saleh, Sara, additional, Bruzek, Amy K., additional, Strong, Michael J., additional, and Park, Paul, additional
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- 2022
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14. Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma
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Cantor, Evan, primary, Wierzbicki, Kyle, additional, Tarapore, Rohinton S, additional, Ravi, Karthik, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Nand Yadav, Viveka, additional, Ravindran, Ramya, additional, Bruzek, Amy K, additional, Wadden, Jack, additional, John, Vishal, additional, May Babila, Clarissa, additional, Cummings, Jessica R, additional, Rahman Kawakibi, Abed, additional, Ji, Sunjong, additional, Ramos, Johanna, additional, Paul, Alyssa, additional, Walling, Dustin, additional, Leonard, Marcia, additional, Robertson, Patricia, additional, Franson, Andrea, additional, Mody, Rajen, additional, Garton, Hugh J L, additional, Venneti, Sriram, additional, Odia, Yazmin, additional, Kline, Cassie, additional, Vitanza, Nicholas A, additional, Khatua, Soumen, additional, Mueller, Sabine, additional, Allen, Joshua E, additional, Gardner, Sharon L, additional, and Koschmann, Carl, additional
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- 2022
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15. CHFR and Paclitaxel Sensitivity of Ovarian Cancer
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Wahner Hendrickson, Andrea E., primary, Visscher, Daniel W., additional, Hou, Xiaonan, additional, Goergen, Krista M., additional, Atkinson, Hunter J., additional, Beito, Thomas G., additional, Negron, Vivian, additional, Lingle, Wilma L., additional, Bruzek, Amy K., additional, Hurley, Rachel M., additional, Wagner, Jill M., additional, Flatten, Karen S., additional, Peterson, Kevin L, additional, Schneider, Paula A, additional, Larson, Melissa C., additional, Maurer, Matthew J., additional, Kalli, Kimberly R., additional, Oberg, Ann L., additional, Weroha, S. John, additional, and Kaufmann, Scott H., additional
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- 2021
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16. BIOM-28. SERIAL PLASMA AND CSF CELL-FREE TUMOR DNA (cf-tDNA) TRACKING IN DIFFUSE MIDLINE GLIOMA PATIENTS UNDERGOING TREATMENT WITH ONC201
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Cantor, Evan, primary, Wierzbicki, Kyle, additional, Tarapore, Rohinton, additional, Ravi, Karthik, additional, Wadden, Jack, additional, Babilla, Clarissa, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Vivek Anand, additional, Ravindran, Ramya, additional, Bruzek, Amy K, additional, Cummings, Jessica, additional, Kawakibi, Abed Rahman, additional, Ji, Sunjong, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Leonard, Marcia, additional, Robertson, Patricia, additional, Franson, Andrea, additional, Mody, Rajen, additional, Garton, Hugh, additional, Odia, Yazmin, additional, Kline, Cassie, additional, Vitanza, Nicholas, additional, Khatua, Soumen, additional, Allen, Joshua, additional, Mueller, Sabine, additional, Gardner, Sharon, additional, and Koschmann, Carl, additional
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- 2021
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17. EPCT-03. SERIAL PLASMA AND CSF CELL-FREE TUMOR DNA (CF-TDNA) TRACKING IN DIFFUSE MIDLINE GLIOMA PATIENTS UNDERGOING TREATMENT WITH ONC201
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Cantor, Evan, primary, Wierzbicki, Kyle, additional, Tarapore, Rohinton S, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka Nand, additional, Ravindran, Ramya, additional, Bruzek, Amy K, additional, Wadden, Jack, additional, Babilla, Clarissa May, additional, Kawakibi, Abed Rhaman, additional, Ji, Sunjong, additional, Ramos, Johanna, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Leonard, Marcia, additional, Robertson, Partricia, additional, Franson, Andrea, additional, Mody, Rajen, additional, Garton, Hugh, additional, Odia, Yazmin, additional, Kline, Cassie, additional, Vitanza, Nicholas A, additional, Khatua, Soumen, additional, Mueller, Sabine, additional, Allen, Joshua E, additional, Gardner, Sharon, additional, and Koschmann, Carl, additional
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- 2021
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18. Serial plasma and CSF cell-free tumor DNA (cf-tDNA) tracking in diffuse midline glioma patients undergoing treatment with ONC201.
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Cantor, Evan, primary, Wierzbicki, Kyle, additional, Tarapore, Rohinton, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka Nand, additional, Ravindran, Ramya, additional, Bruzek, Amy, additional, Franson, Andrea, additional, Mody, Rajen, additional, Garton, Hugh, additional, Odia, Yazmin, additional, Kline, Cassie, additional, Vitanza, Nicholas A, additional, Khatua, Soumen, additional, Mueller, Sabine, additional, Allen, Joshua E., additional, Gardner, Sharon L., additional, and Koschmann, Carl Johannes, additional
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- 2021
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19. Everolimus improves the efficacy of dasatinib in the treatment of PDGFRA-driven glioma
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Miklja, Zachary, Yadav, Vivek Nand, Cartaxo, Rodrigo, Siada, Ruby, Mullan, Brendan, Stallard, Stefanie, Paul, Alyssa, Bruzek, Amy K., Wierzbicki, Kyle, Yang, Tao, Garcia, Taylor, Wolfe, Ian, Parmar, Hemant, Leonard, Marcia, Robertson, Patricia L., Garton, Hugh, Venneti, Sriram, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Manjunath, Pai P., Phoenix, Timothy N., Marini, Bernard L., and Koschmann, Carl
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hemic and lymphatic diseases ,digestive system diseases - Abstract
Background: Pediatric and adult high-grade glioma (HGG) frequently harbor PDGFRA alterations. Treatment of PDGFRA-driven HGG with targeted agents, such as the tyrosine kinase inhibitor dasatinib, has failed in the clinic. We hypothesized that co-treatment with everolimus may improve the efficacy of dasatinib in PDGFRA-driven glioma through combinatorial synergism and increased tumor accumulation of dasatinib. Methods: Dose response, synergism studies, P-gp inhibition and pharmacokinetic studies were performed on in vitro and in vivo human and mouse models of HGG. De novo tumors were generated in mice using intra-uterine electroporation (IUE) by injecting PB plasmids of TP53 mutation, PDGFRA mutation and H3K27M mutation (PPK) in the lateral vertical of mice embryos. Two children with recurrent PDGFRA-driven HGG were treated with dasatinib and everolimus with correlate CSF analysis. Results: Dasatinib effectively inhibited the proliferation of mouse and human primary HGG cells with a dose-dependent reduction of PDGFRA and pPDGFRA. Dasatinib exhibited synergy with everolimus in the treatment of HGG cells at low nanomolar concentrations of both agents. Prolonged exposure to everolimus significantly improved the CNS retention of dasatinib and extended survival of PPK tumor bearing mice. Two children with recurrent PDGFRA-driven HGG treated with dasatinib and everolimus survived six months and nine months after progression. A paired CSF sample from the patient with PDGFRA-amplified HGG showed 50% increase in CSF dasatinib levels after the addition of everolimus. Conclusion: Efficacy of dasatinib treatment of PDGFRA-driven HGG is improved with everolimus and suggests a promising route for improving targeted therapy for this patient population. Clinical Trial Registration ID # NCT03352427 .
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- 2020
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20. DIPG-08. ELECTRONIC SEQUENCING PROVIDES OPTIMIZED QUANTIFICATION OF SERIAL, MULTI-GENE MOLECULAR RESPONSE IN THE CSF OF CHILDREN WITH HIGH-GRADE GLIOMA
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Bruzek, Amy, primary, Muruganand, Ashwath, additional, Ravi, Karthik, additional, Wadden, Jack, additional, Babila, Clarissa, additional, Tunkle, Leo, additional, Wierzbicki, Kyle, additional, Stallard, Stefanie, additional, Cantor, Evan, additional, Qin, Tingting, additional, Wolfe, Ian, additional, Mody, Rajen, additional, Muraszko, Karin, additional, Franson, Andrea, additional, Robertson, Patrica, additional, Maher, Cormac, additional, Garton, Hugh, additional, and Koschmann, Carl, additional
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- 2020
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21. Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma
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Bruzek, Amy K., primary, Ravi, Karthik, additional, Muruganand, Ashwath, additional, Wadden, Jack, additional, Babila, Clarissa May, additional, Cantor, Evan, additional, Tunkle, Leo, additional, Wierzbicki, Kyle, additional, Stallard, Stefanie, additional, Dickson, Robert P., additional, Wolfe, Ian, additional, Mody, Rajen, additional, Schwartz, Jonathan, additional, Franson, Andrea, additional, Robertson, Patricia L., additional, Muraszko, Karin M., additional, Maher, Cormac O., additional, Garton, Hugh J.L., additional, Qin, Tingtin, additional, and Koschmann, Carl, additional
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- 2020
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22. HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA
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Kawakibi, Abed Rahman, primary, Tarapore, Rohinton S, additional, Gardner, Sharon, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick Y, additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy T, additional, Butowski, Nicholas A, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, DeGroot, John, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew D, additional, Daghistani, Doured, additional, Cloughesy, Timothy F, additional, Ellingson, Benjamin M, additional, Umemura, Yoshie, additional, Schwartz, Jonathan, additional, Yadav, Vivekanand, additional, Cartaxo, Rodrigo, additional, Siada, Ruby, additional, Miklja, Zachary, additional, Bruzek, Amy, additional, Cantor, Evan, additional, Wierzbicki, Kyle, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Leaoard, Marcia, additional, Garton, Hugh, additional, Mody, Rajen, additional, Robertson, Patricia L, additional, Lu, Guangrong, additional, Merdinger, Krystal, additional, Venneti, Sriram, additional, Oster, Wolfgang, additional, Allen, Joshua E, additional, and Koschmann, Carl, additional
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- 2020
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23. Contributors
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Aarabi, Bizhan, Abbott, Rick, Abd-El-Barr, Muhammad M., Abel, Taylor J., Abou-Al-Shaar, Hussam, Acar, Feridun, Achey, Rebecca L., Ackerman, Laurie L., Adappa, Nithin D., Adelson, P. David, Agarwal, Nitin, Aguirre-Padilla, David H., Ahluwalia, Manmeet S., Ahmad, Shahjehan, Ahmed, A. Karim, Ahmed, Raheel, Aisiku, Imoigele P., Akbar, Muhammad A., Akram, Harith, Alaraj, Ali, Albrecht, Jennifer S., Albuquerque, Felipe C., Alexander, Michael J., Alexandrov, Andrei V., Alexopoulos, Andreas V., Ali, Zarina S., Al-Khalili, Kenan, Al-Mefty, Ossama, Al-Mefty, Rami O., Alnahhas, Iyad, Alrobaian, Malek, Al-Saiegh, Fadi, Alterman, Ron L., Altshuler, David B., Amenta, Peter S., Ames, Christopher P., Amin-Hanjani, Sepideh, Ammirati, Mario, Andaluz, Norberto, Anderson, Richard C.E., Andrade, Pablo, Ares, William J., Arle, Jeffrey E., Arnaout, Omar, Arnold, Paul M., Assina, Rachid, Aszmann, Oskar C., Attenello, Frank J., III, Attia, Albert, Avellino, Anthony M., Awad, Issam A., Ayantayo, Temitayo O., Bader, Edward R., Badhiwala, Jetan H., Baehring, Joachim M., Bagic´, Anto I., Bagley, Stephen J., Bai, Michael Y., Bailes, Julian E., Bain, Mark, Baker, Turner, Ball, Perry A., Ballester, Leomar Y., Balu, Ramani, Ban, Vin Shen, Barak, Tanyeri, Baranoski, Jacob F., Barbaro, Nicholas M., Barber, Sean M., Barker, Frederick G., II, Barnett, Gene H., Barone, Constance M., Barrow, Daniel Louis, Basma, Jaafar, Batchelor, Tracy T., Batjer, H. Hunt, Beattie, Michael S., Beaumont, Andrew, Beaumont, Thomas L., Bederson, Joshua B., Belani, Puneet, Belzberg, Allan J., Benet, Arnau, Ben-Haim, Sharona, Berenstein, Alejandro, Berga, Sarah L., Berger, Mitchel S., Bergsneider, Marvin, Bernstock, Joshua D., Bhatia, Sanjay, Bi, Wenya Linda, Bigder, Mark G., Bijlenga, Philippe, Bingaman, William, Birk, Harjus S., Bishop, Allen T., Blakeley, Jaishri O., Blomstedt, Patric, Blue, Rachel, Blumenthal, Scott, Boaro, Alessandro, Boddu, James V., Bohnen, Angela, Bok, Arnold P., Boone, Myles D., Boop, Frederick A., Boszczyk, Bronek M., Bowyer, Susan M., Brahimaj, Bledi C., Brem, Henry, Brem, Steven, Bresnahan, Jacqueline C., Brinjikji, Waleed, Brinkmann, Benjamin H., Brînzeu, Andrei, Britz, Gavin W., Brockmeyer, Douglas L., Brown, Desmond A., Brown, Justin M., Brown, Matthew T., Brown, Robert D., Jr., Bruce, Jeffrey N., Bruckman, Karl C., Bruhat, Alexis, Brunstrom-Hernandez, Janice E., Brunswick, Andrew, Bruzek, Amy K., Buchanan, Ian A., Budohoski, Karol P., Buell, Thomas J., Büki, András, Bunevicius, Adomas, Burchiel, Kim J., Bydon, Mohamad, Byrne, Richard W., Cabrejo, Raysa, Cabrilo, Ivan, Cahill, Daniel P., Caplan, Justin M., Carlson, Andrew P., Carrión-Penagos, Julián, Carroll, Benjamin W., Cascino, Gregory D., Castaneyra-Ruiz, Leandro, Castinetti, Frederic, Cavalcanti, Daniel D., Cawley, C. Michael, Cernak, Ibolja, Cetas, Justin S., Chan, Michael D., Ka-Ying Chan, Vivien, Chang, Chih-Chang, Chang, Louis, Chang, Steven D., Charbel, Fady T., Charest-Morin, Raphaële, Chari, Aswin, Chaudhary, Navjot, Chauvel, Patrick, Chen, Kevin S., Chen, Liang, Cheng, Joseph, Cherian, Jacob, Cheung, Kenneth M.C., Cheyuo, Cletus, Chiang, Veronica L., Chiarelli, Peter A., Chiocca, E. Antonio, Chitale, Rohan V., Cho, Catherine, Choi, Heejung, Chou, Dean, Christian, Cindy W., Christiansen, Peter A., Church, Ephraim W., Clarke, Jennifer L., Cleary, Daniel R., Clune, James E., Cohen, Justin D., Cohen-Inbar, Or, Colasanti, Roberto, Collins, John M., Comair, Youssef G., Conner, Andrew K.P., Connolly, E. Sander, Jr., Cooper, Jared B., Corcos, Daniel Montie, Coric, Domagoj, Costa, Anthony B., Couldwell, William T., Crino, Peter B., Crofton, Andrew R., Cullen, D. Kacy, Curt, Armin, Dacey, Ralph G., Jr., Daci, Rrita, Dailey, Andrew T., D’Alessandris, Quintino Giorgio, Damisah, Eyiyemisi C., Daniels, David J., Das, Sunit, Davanzo, Justin R., David, Carlos A., David, David J., Davidson, Benjamin, Davis, Gavin A., Day, Arthur L., Dea, Nicolas, De Donato, Giuseppe, Deiner, Stacie, De la Garza, Carlos, Delavari, Nader, Del Brutto, Oscar H., Delman, Bradley N., DeLong, Mahlon R., DeMonte, Franco, de Oliveira, Evandro, Derman, Peter B., Desai, Arati, Deshpande, Krutika, Diaz, Michele, Diaz-Arrastia, Ramon R., DiGiorgio, Anthony M., DiLuna, Michael L., DiMeco, Francesco, Dlouhy, Brian J., Doğruel, Yücel, Donahue, Joseph H., Donoho, Daniel A., Doshi, Amish H., Dreier, Jens P., Driver, Joseph, Drofa, Alexander, Ducruet, Andrew F., Duffau, Hugues, Duhaime, Ann-Christine, Dumont, Aaron S., Duncan, John S., Dunn, Gavin P., Dunn, Ian F., Eberwine, James H., Eckardt, Gerald W., Edem, Idara J., Edwards, Michael S.B., Egemen, Emrah, Eisenbarth, Rachel, Eisenberg, Howard, Elder, J. Bradley, Elhammady, Mohamed Samy, Elias, W. Jeffrey, Ellingson, Benjamin M., Ellis, Jason A., Elswick, Clay M., Emch, Todd M., Emerson, Samuel, Ene, Chibawanye I., Englot, Dario J., Erdman, John H., III, Eskandari, Ramin, Essayed, Walid Ibn, Everson, Richard G., Fadul, Camilo E., Fan, Yi, Farina, Dario, Farrell, Christopher J., Feghali, James, Fehlings, Michael G., Fehnel, Katie Pricola, Feigin, Valery L., Feldman, Eva L., Feldman, Michael J., Feldstein, Neil, Fenno, Lief E., Ferguson, Adam R., Feroze, Abdullah H., Fessler, Richard G., Filler, Aaron G., Findlay, J. Max, Finn, Michael A., Finnell, Richard H., Fisher, Charles G., Flamm, Eugene S., Flanders, Tracy M., Flemming, Kelly D., Flores-Sarnat, Laura, Follett, Kenneth A., Fontes, Ricardo B.V., Ford, Paul J., Foreman, Brandon P., Foreman, Paul M., Fornoff, Linden E., Fouda, Mohammed A., Foyouzi, Nastaran, Franco, Daniel, Franzini, Andrea, Fridley, Jared S., Friedlander, Robert M., Frisoli, Fabio A., Fry, Donald E., Gregory Fu, Kai-Ming, Fujita, Naohide, Fulbright, Robert K., Fulkerson, Daniel H., Fuller, Gregory N., Fusco, Matthew R., Galanopoulou, Aristea S., Gallagher, Gary W., Galvan, Adriana, Gander, Phillip E., Gandhi, Chirag D., Gao, Guoyi, Garcia, Hector H., García, Paul S., Gardner, Paul A., Gardner, Raquel C., Garzon-Muvdi, Tomas, Gavin, Cormac G., Gea-Banacloche, Juan C., George, Timothy M., Georgoulis, George D., Gerard, Carter S., Gerety, Patrick A., Gerszten, Kristina, Gerszten, Peter C., Ghaith, Abdul Karim, Ghatan, Saadi, Ghobrial, George M., Ghogawala, Zoher, Ghosh, Chaitali, Giacino, Joseph T., Giacobbe, Peter, Gianaris, Thomas J., Giannotta, Steven L., Giglio, Pierre, Gilad, Ronit, Gill, Brian J.A., Gillick, John L., Gilmer, Holly S., Gjedde, Albert H., Glenn, Chad A., Godil, Saniya S., Goel, Atul, Gokaslan, Ziya L., Goldberg, Jacob L., Goldstein, Hannah E., Golub, Danielle, Gonzalez, Glenn A., Gonzalez-Martinez, Jorge Á., Goodden, John R., Goodman, J. Clay, Goodrich, James Tait, Goodwin, C. Rory, Gordon, David S., Gottfried, Oren N., Goumnerova, Liliana C., Goyal, Anshit, Grady, M. Sean, Graffeo, Christopher S., Grafman, Jordan H., Gragnaniello, Cristian, Grande, Andrew W., Grant, Gerald A., Grebenciucova, Elena, Greenfield, Jeffrey, Grimaudo, Heather C., Groff, Michael W., Gross, Robert E., Grossman, Rachel, Groves, Mari L., Gstoettner, Clemens, Guenette, Jeffrey P., Günel, Murat, Gupta, Nalin, Gutman, Matthew J., Guyer, Richard D., Hachem, Laureen D., Haddad, Georges F., Hadjipanayis, Constantinos G., Hafez, Daniel M., Hagan, John P., Haglund, Michael M., Haines, Stephen J., Haldeman, Clayton L., Halvorson, Kyle G., Hamberger, Marla J., Hamdi, Hussein, Hamilton, D. Kojo, Hamilton, Kimberly M., Hamilton, Mark G., Hankinson, Todd C., Haq, Ihtsham ul, Harbaugh, Robert E., Hardesty, Douglas A., Hardigan, Trevor, Hariz, Marwan, Harrigan, Mark R., Harrop, James S., Hartings, Jed A., Härtl, Roger, Harward, Stephen C., II, Hasbun, Rodrigo, Hawryluk, Gregory W.J., Hayman, Erik, Hayward, Richard D., He, Lucy, Healy, Andrew T., Heary, Robert F., Heiden, Petra, Heinricher, Mary M., Heller, Robert S., Retel Helmrich, Isabel R.A., Helmy, Adel, Heman-Ackah, Sabrina M., Hendricks, Benjamin K., Herendeen, John S., Heros, Roberto C., Herrup, Karl, Hervey-Jumper, Shawn L., Heuer, Gregory G., Heyer, Eric J., Higuchi, Yoshinori, Hillary, Frank G., Ho, Winson S., Hoang, Nguyen, Hoang, Stanley, Hoelscher, Christian, Hoffer, S. Alan, Hofstetter, Christoph, Holland, Eric C., Holland, Ryan M., Holste, Katherine, Hongo, Kazuhiro, Horisawa, Shiro, Horner, Philip J., Howard, Matthew A., III, Hsueh, Brian, Huang, Judy, Huang, Kevin T., Huang, Michael C., Huang, Raymond Y., Hudgins, Eric, Huguenard, Anna, Hunt, Matthew A., Hurlbert, R. John, Hussein, Ahmed E., Hutchinson, Peter J., Huttner, Anita, Huys, Daniel, Hwang, Steven W., Iaccarino, Mary A., Ibrahim, Mohab, Iliff, Jeffrey J., Ilyas, Adeel, Ingram, Susan L., Isaacs, Albert M., Isaias, Ioannis U., Iskandar, Bermans J., Iyer, Aditya K., Jabbour, Pascal, Jackson, Christopher M., Jadhav, Ashutosh P., Jakobs, Martin, Jallo, George I., Jane, John A., Jr., Janigro, Damir, Jankowitz, Brian T., Jea, Andrew, Jehi, Lara, Jellinger, Kurt A., Jenson, Amanda V., Jho, Diana, Jiang, Bowen, Jiang, Fan, Jimenez, David F., Jimenez, Lincoln, Jin, Haiyan, Jo, Jasmin T., Johanson, Conrad E., Johnson, Luke A., Johnson, Mark D., Johnson, Nathaniel, Jones, Adrian C., Jones, Kristen E., Jones, Tuckerman, Joseph, Jacob R., Joshi, Krishna C., Joshi, Rushikesh S., Jovin, Tudor G., Julian, Alex, Juraschka, Kyle, Abdo do Seixo Kadri, Paulo, Kalani, M. Yashar S., Kalanithi, Paul S.A., Kalfas, Iain H., Kalnins, Aleksandrs Uldis, Kamath, Ashwin A., Kanev, Paul M., Kang, Daniel G., Kang, James D., Kanter, Adam S., Kaplitt, Michael G., Kappel, Ari D., Karikari, Isaac, Karsy, Michael, Kasliwal, Manish K., Kaufmann, Anthony M., Kawasaki, Hiroto, Kellner, Christopher P., Kelly, Alexander P., Kemeny, Andras A., Kestle, John R.W., Khalsa, Siri S., Khan, Imad S., Khan, Nadia, Khan, Tariq, Khanna, Omaditya, Khanna, Ryan, Kigerl, Kristina A., Kim, Dong H., Kim, Louis J., Kim, Paul K., Kim, Thomas A., Kim, Won, Kirnaz, Sertaç, Kirsch, Wolff, Kitchen, Neil D., Klein, Joshua P., Kliot, Michel, Knightly, John J., Knisely, Jonathan, Knopman, Jared, Ko, Andrew L., Kobayashi, Katsuya, Kobets, Andrew J., Koch, Matthew J., Kocharian, Gary, Koerner, John D., Kohara, Kotaro, Kohn, Max, Kolias, Angelos G., Koo, Clara S., Kosztowski, Thomas, Kotecha, Rupesh R., Kovach, Christopher K., Kraemer, Mark R., Krauss, Joachim K., Krieg, Sandro M., Krieger, Mark D., Krishnaney, Ajit A., Ksendzovsky, Alexander, Kulkarni, Abhaya V., Vijay Kumar, Gomatam R., Kumar, Sachin A., Kung, David K., Kuo, Jeffrey V., Kvint, Svetlana, Kwan, Kenny, Issa Laack, Nadia N., Ladner, Travis R., Lafage, Renaud, Lafage, Virginie, Lam, Arthur M., Lamm, Adam G., Landazuri, Patrick, Lanzino, Giuseppe, Larson, Paul, Lau, Catherine Y., Lau, Darryl, Lavine, Sean D., Lawler, Sean E., Laws, Edward R., Jr., Lawton, Michael T., Laxpati, Nealen G., Lebed, Brett D., Lee, Cheng-Chia, Lee, Jonathan J., Lee, Ryan P., Lee, Sangmi, Lehman, Ronald A., Jr., Lenke, Lawrence G., Le Roux, Peter D., Leuthardt, Eric C., Levin, Emily, Levy, Elad I., Lewis, Evan M., Lhatoo, Samden, Li, Dianyou, Li, Yingda, Ching Ng, Angela Li, Liau, Linda M., Liebenow, Brittany, Lieberman, Isador H., Limbrick, David D., Jr., Lin, Emily, Lin, Kant Y., Lin, Zhengyu, Lingsma, Hester F., Linskey, Mark E., Lipsman, Nir, Litvack, Zachary N., Liu, James K.C., Liu, Kenneth C., Liu, Wei, Lober, Robert M., Lohkamp, Laura-Nanna, Lonser, Russell R., Louvi, Angeliki, Lozano, Andres M., Lu, Victor M., Luciano, Mark G., Lukas, Rimas V., Luo, Lan, Ma, Lijun, Maas, Andrew I.R., Macdonald, R. Loch, Mack, William J., Mackey, Kimberly A., Macki, Mohamed, MacLachlan, Lara S., Madarash, Holly Oemke, Madsen, Peter J., Maegele, Marc, Magistretti, Pierre J., Mahan, Mark A., Maher, Cormac O., Mahtabfar, Aria, Majeed, Kashif, Makarenko, Serge, Makley, Amy T., Malessy, Martijn J.A., Malik, Athar N., Mallucci, Conor, Mambelli, Dorian D., Mammi, Marco, Mangano, Francesco T., Maniker, Allen H., Manley, Geoffrey T., Manolidis, Spiros, Maroon, Joseph C., Martin, Alastair, Martin, Neil A., Martirosian, Vahan, Martirosyan, Nikolay L., Maslink, Colin, Massie, Lara, Mathur, Amit M., Matias, Caio M., Mauer, Kimberly M., Maulucci, Christopher M., Maurer, Robert K., Mazur, Marcus D., Mazwi, Nicole, McAllister, James P., II, McClain, Craig D., McCormack, Ryan M., McCrea, Michael A., McCutcheon, Ian E., McDermott, Michael W., McDougall, Cameron G., McDougall, Cameron M., McEvoy, Andrew W., McGrath, Hari, McGrath, Lynn, Jr., McKhann, Guy M., McMahon, J. Tanner, McPheeters, Matthew J., Meaney, David F., Medel, Ricky, Medress, Zachary, Mehta, Minesh P., Menacho, Sarah T., Menezes, Arnold H., Menon, David K., Mergeche, Joanna L., Meyer, Fredric B., Meyer, Jenna, Meyer, Scott A., Meyers, Philip M., Midha, Rajiv, Miller, Charles A., Miller, Jonathan P., Miller, Neil R., Mirza, Farhan A., Mirzadeh, Zaman, Miserocchi, Anna, Misra, Basant K., Missios, Symeon, Miyagishima, Danielle F., Miyashiro, Kevin Y., Mizuno, Junichi, Mizuno, Shuichi, Mocco, J., Mohyeldin, Ahmed, Mokin, Maxim, Molinaro, Annette M., Moliterno, Jennifer, Monteith, Stephen J., Montenegro, Thiago S., Mooney, Michael A., Moosa, Shayan, Morales, Diego M., Morgan, Clinton D., Morgan, Isabella, Morgan, Michael Kerin, Mortimer, Vance R., Moss, Nelson, Moss, S. David, Mukherjee, Pratik, Mummaneni, Praveen V., Munich, Stephan A., Muraszko, Karin, Murthy, Saikiran G., Mushlin, Harry, Mussi, Antônio C.M., Nagel, Sean J., Nagy, Gábor, Nair, Dileep R., Najm, Imad M., Nakaji, Peter, Nakajima, Takeshi, Nasser, Rani, Nater, Anick, Navarro, Jovany Cruz, Nayak, Lakshmi, Neira, Justin A., Nelson, Lindsay D., Neman, Josh, Newell, David W., Nguyen, James H., Ngwenya, Laura Benjamin, Nicolato, Antonio, Nimjee, Shahid M., Nishimura, Sayoko, Niu, Tianyi, Norris, Scott A., Noureldine, Mohammad Hassan A., Nurmikko, Turo J., Nuwer, Marc R., Oberheim-Bush, Nancy Ann, Ochiai, Taku, Oh, Nathan, Oh, Taemin, Okonkwo, David O., Okun, Michael S., Oldfield, Edward H., Brigid O’Leary, Joanna Shawn, Olivi, Alessandro, O’Neill, Francis, Oppenlander, Mark E., Osbun, Joshua W., O’Toole, John E., Özduman, Koray, Ozpinar, Alp, Pain, Margaret, Palacios, Eva M., Palmer, James N., Pamir, M. Necmettin, Pamoukian, Vicken, Panesar, Sandip S., Panov, Fedor E., Paramasivam, Srinivasan, Park, Christine, Park, Jon, Park, Paul, Park, T.S., Parker, Whitney E., Parsa, Andrew T., Partington, Michael D., Patel, Aman B., Patel, Bhuvic, Patel, Smruti K., Patel, Vaibhav M., Patil, Parag G., Payne, Russell, Peeters, Sophie M., Pekmezci, Melike, Pendharkar, Arjun V., Penn, Richard Deren, Pennicooke, Brenton H., Pennington, Zach, Della Pepa, Giuseppe Maria, Perin, Alessandro, Perlmutter, Joel S., Persing, J. Scott, Persing, John A., Persing, Sarah M., Peters, Matthew E., Petersen, Erika A., Petrov, Dmitriy, Pham, Martin, Picht, Thomas, Piepmeier, Joseph M., Pikis, Stylianos, Pilcher, Webster H., Pinckard-Dover, Heather N., Pineda, José A., Pinter, Joseph D., Pisculli, Mary L., Pittman, Thomas, Plesnila, Nikolaus, Pollack, Ian F., Pollock, Bruce E., Polly, David W., Jr., Polster, Sean P., Popovich, Phillip G., Post, Kalmon D., Potts, Matthew B., Pouratian, Nader, Powers, Alexander K., Prager, Briana C., Prashant, Giyarpuram N., Prestigiacomo, Charles J., Prevedello, Daniel M., Proctor, Mark R., Prolo, Laura M., Prost, Robert W., Puduvalli, Vinay K., Purger, David A., Qualmann, Krista J., Quiñones-Hinojosa, Alfredo, Raffa, Scott J., Raghavan, Prashant, Rahal, Jason Pierce, Rajappa, Prajwal, Ram, Zvi, Ranjan, Manish, Rao, Ganesh, M.S. Raper, Daniel, Rapoport, Benjamin I., Raskin, Jeffrey S., Raslan, Ahmed M., Rasmussen, Peter, Rasouli, Jonathan J., Ravindra, Vijay M., Ray, Dibyendu K., Ray, Wilson Z., Raz, Eytan, Raza, Shaan M., Régis, Jean, Reilly, Peter L., Reith, Florence C.M., Rennert, Robert C., Resnick, Daniel K., Reynolds, Renée, Rezai, Ali R., Rhines, Laurence D., Rhoton, Albert L., Jr., Ribalta, Teresa, Richardson, R. Mark, Riggins, Gregory J., Riina, Howard A., Rinaldo, Lorenzo, Rincon-Torroella, Jordina, Ringer, Andrew J., Riva-Cambrin, Jay, Rizk, Elias, Robert, Stephanie M., Robertson, Claudia, Robertson, Jon H., Robinson, Leslie C., Robinson, Michael W., Robinson, Shenandoah, Roche, Aidan D., Roche, Pierre-Hugues, Rogg, Jeffrey M., Roguski, Marie, Roland, Jarod L., Rolston, John D., Rosenberg, William S., Rosenow, Joshua M., Rosenthal, Guy, Rosenwasser, Robert H., Roser, Florian, Rosner, Michael K., Rosseau, Gail, Rossi, Vincent J., Rovner, Eric S., Rubiano, Andres M., Rubio, Roberto Rodriguez, Rucker, Janet C., Rui, Yanning, Russin, Jonathan J., Rutka, James T., Saadeh, Yamaan S., Saatian, Behnaz, Sack, Kenneth D., Sader, Nicholas, Safaee, Michael M., Safain, Mina G., Sagher, Oren, Sahgal, Arjun, Saigal, Rajiv, Saito, Nobuhito, Saleh, Mohamed, Salinas, Ryan D., Salminger, Stefan, Samarage, H. Milan, Samdani, Amer F., Sand, Lauren A., Sani, Sepehr, Sankaran, Sujatha, Sansur, Charles A., Santarius, Thomas, Santiago, Paul, Santiago-Dieppa, David R., Santiago-Sim, Teresa, Sarkiss, Christopher A., Sarnat, Harvey B., Sarris, Christina E., Sather, Michael, Savastano, Luis E., Sawaya, Raymond, Schaller, Karl, Schiff, Nicholas D., Schipmann, Stephanie, Schlachter, Leslie, Schlesinger, David J., Schmidt, Franziska A., Schmidt, Meic H., Schneider, Lonnie, Schramm, Johannes, Schuele, Stephan U., Schulder, Michael, Schupper, Alexander J., Schwab, Frank J., Schwartz, Theodore H., Sciubba, Daniel M., Scott, R. Michael, Scullen, Tyler A., Selden, Nathan R., Sellin, Jonathan N., Selman, Warren R., Sen, Chandranath, Serizawa, Toru, Serrone, Joseph C., Sgubin, Donatella, Shaffrey, Christopher I., Shah, Kushal J., Shah, Lubdha M., Shah, Manish N., Shahlaie, Kiarash, Shapiro, Maksim, Sharan, Ashwini, Sharma, Deepak, Sharma, Mohan R., Sheehan, Jason P., Sheehan, Jonas M., Sheikhi, Lila, Shiflett, James M., Shigamatsu, Tomoyoshi, Shilpakar, Sushil Krishna, Shils, Jay L., Shimony, Nir, Shin, Alexander Y., Siddiqui, Adnan H., Sidhu, Meneka K., Silveira, Luke A., Silver, Jerry, Sindou, Marc, Singh, Jeffrey M., Singh, Manish K., Sizdahkhani, Saman, Skirboll, Stephen, Slavin, Justin, Smith, Brandon W., Smith, Edward R., Smith, Justin S., Smith, Kris A., Smith, Luke G.F., Smith, Timothy R., Smith, Yoland, Solomon, David A., Solomon, Robert A., Soltys, Scott G., Somji, Mohamed, Sorenson, Jeffrey M., Soriano, Sulpicio G., Sorscher, Michelle, Souweidane, Mark M., Spencer, Dennis D., Spetzler, Robert F., Spinazzi, Eleonora F., Spinner, Robert J., Sribnick, Eric A., Srinivasan, Visish M., Stabingas, Kristen, Stapleton, Christopher J., Starke, Robert M., Starr, Philip, St. Clair, Eric G., Stedelin, Brittany, Stefko, S. Tonya, Steinberg, Gary K., Stern, Matthew A., Steyerberg, Ewout W., Stieg, Philip E., Stone, Scellig S.D., Stoodley, Marcus, Strahle, Jennifer M., Stricsek, Geoffrey, Strong, Anthony, Strowd, Roy E., III, Stummer, Walter, Su, YouRong S., Sughrue, Michael E., Suh, John H., Sulaiman, Wale A.R., Sun, Bomin, Sun, Matthew Z., Sun, Xiaonan Richard, Sundaram, Vikram K., Sweid, Ahmad, Syed, Hasan R., Tagliati, Michele, Taira, Takaomi, Tajsic, Tamara, Takagi, Yasushi, Takeoka, Yoshiki, Tamargo, Rafael J., Tanaka, Shota, Tandon, Nitin, Tang, Daniel D., Tanweer, Omar, Tate, Matthew C., Tatsui, Claudio E., Taylor, Jennie W., Taylor, Jesse A., Taylor, Michael D., Templer, Jessica W., Teo, Charles, Tessier, Jeffrey M., Theadom, Alice, Theodore, Nicholas, Thinwa, Josephine W., Thompson, B. Gregory, Jr., Thompson, Eric M., Thompson, Stephen A., Thon, Niklas, Thurtell, Matthew J., Tilton, Ann H., Timmons, Shelly D., Tonn, Jörg-Christian, Toth, Gabor, Toussaint, Charles P., Tran, Minh H., Trapp, Bruce D., Traylor, Jeffrey I., Trifiletti, Daniel M., Tse, Kai-Hei, Tubbs, R. Shane, Tuleasca, Constantin, Tunkel, Allan R., Türe, Ugur, Umansky, Daniel, Unda, Santiago R., Ung, Timothy H., Upadhyayula, Pavan S., Uribe, Juan S., Uy, Benjamin R., Vaccaro, Alexander R., Vakharia, Kunal, Vakharia, Vejay N., Valvassori, Luca, van den Bent, Martin J., Van Gompel, Jamie J., Vasquez, Carlos M., Vasudeva, Viren S., Vasudevan, Kumar, Vellimana, Ananth K., Verlicchi, Angela, Vervoordt, Samantha M., Viapiano, Mariano S., Vide, Sérgio, Villa, Genaro R., Virk, Michael S., Visser-Vandewalle, Veerle, Vitek, Jerrold L., Vivas-Buitrago, Tito, Vo, Chau D., Vogelbaum, Michael A., Vollmer, Dennis G., Wackym, P. Ashley, Wainwright, Mark S., Wali, Arvin R., Walker, Corey T., Walters, Beverly C., Wang, Anthony C., Wang, Arthur, Wang, Huan, Wang, Joshua L., Wang, Kevin K.W., Wang, Michael Y., Wang, Minghao, Wang, Shelly, Wang, Tao, Wang, Tony R., Wang, Vincent Y., Waqas, Muhammad, Warf, Benjamin C., Weiner, Howard L., Weingart, Jon D., Weinstein, Lawrence, Weiss, Martin H., Weiss, Nirit, Welch, Babu G., Wellons, John C., III, Wen, Hung Tzu, Wen, Patrick Y., West, G. Alexander, Wewel, Joshua T., Whitehead, William E., Whiting, Alexander C., Whiting, Donald M., Wichmann, Thomas, Wilkinson, D. Andrew, Williams, Michael A., Williams-Medina, Alberto R., Williamson, Theresa, Wilson, Lindsay, Winer, Jesse L., Winfree, Christopher J., Winkler, Ethan A., Winn, H. Richard, Wintermark, Max, Wipplinger, Christoph, Witiw, Christopher D., Wolfla, Christopher E., Wolinsky, Jean-Paul, Wong, Eric T., Worrell, Gregory A., Wrensch, Margaret R., Wright, Christina H., Wu, Jau-Ching, Wu, Jenny, Wu, Kyle C., Wu, Pang Hung, Xu, David S., Xu, Linda Wei, Xu, Yifan, Xu, Zhen, Xu, Zhiyuan, Yaeger, Kurt A., Yahanda, Alexander T., Yan, Rachel E., Yan, Yuanqing, Yang, George L., Yasuno, Katsuhito, Yen, Chun-Po, Yokota, Kazuya, Yolcu, Yagiz Ugur, Young, Timothy P., Yu, Jennifer S., Yue, John K., Yuh, Esther L., Zabramski, Joseph M., Zacest, Andrew, Zacko, J. Christopher, Zada, Gabriel, Zafonte, Ross D., Zager, Eric L., Zakare-Fagbamila, Rasheedat T., Zakeri, Amanda, Zanotti, Bruno, Zawar, Ifrah, Zeineddine, Hussein A., Zellner, Elizabeth G., Zhan, Shikun, Zhang, Chencheng, Zhang, Michael, Zhang, Yingying, Zibly, Zion, Zigler, Jack E., Zipfel, Gregory J., Zipser, Carl Moritz, Zrinzo, Ludvic, and Zumofen, Daniel W.
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- 2023
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24. CTNI-17. CLINICAL EFFICACY AND PREDICTIVE BIOMARKERS OF ONC201 IN H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA
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Rahman Kawakibi, Abed, primary, Tarapore, Rohinton S, additional, Gardner, Sharon, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka Nand, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, de Groot, John, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Umemura, Yoshie, additional, Garton, Hugh, additional, Franson, Andrea, additional, Robertson, Patricia, additional, Schwartz, Jonathan, additional, Cantor, Evan, additional, Miklja, Zachary, additional, Mullan, Brendan, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Cummings, Jessica, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Jiang, Li, additional, Filbin, Mariella, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Venneti, Sriram, additional, Lu, Guangrong, additional, Mueller, Sabine, additional, Martinez, Daniel, additional, Resnick, Adam, additional, Nazarian, Javad, additional, Waszak, Sebastian, additional, Allen, Joshua, additional, and Koschmann, Carl, additional
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- 2020
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25. Clinical efficacy and predictive biomarkers of ONC201 in H3 K27M-mutant diffuse midline glioma
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Koschmann, Carl, primary, Kawakibi, Abed Rahman, additional, Tarapore, Rohinton, additional, Gardner, Sharon, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, Groot, John De, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Kim, Michelle, additional, Umemura, Yoshie, additional, Garton, Hugh, additional, Franson, Andrea, additional, Robertson, Patricia, additional, Schwartz, Jonathan, additional, Marini, Bernard, additional, Pai, Manjunath, additional, Phoenix, Timothy, additional, Ji, Sunjong, additional, Cantor, Evan, additional, Miklja, Zachary, additional, Mullan, Brendan, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Cummings, Jessica, additional, Stallard, Stefanie, additional, Wierzbicki, Kyle, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Dun, Matthew, additional, Cain, Jason, additional, Jiang, Li, additional, Filbin, Mariella, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Pratt, Drew, additional, Venneti, Sriram, additional, Lu, Guangrong, additional, Mueller, Sabine, additional, Resnick, Adam, additional, Nazarian, Javad, additional, Waszak, Sebastian, additional, and Allen, Joshua, additional
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- 2020
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26. Posterior Cranial Vault Distraction Osteogenesis: Routine Low Occipital Craniotomy Is a Safe Approach That Optimizes Outcomes
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Ulma, Raquel M., primary, Sacks, Gina, additional, Bruzek, Amy K., additional, Vercler, Christian J., additional, Muraszko, Karin, additional, and Buchman, Steven R., additional
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- 2020
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27. Syringomyelia in children with closed spinal dysraphism: long-term outcomes after surgical intervention
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Bruzek, Amy K., primary, Starr, Jordan, additional, Garton, Hugh J. L., additional, Muraszko, Karin M., additional, Maher, Cormac O., additional, and Strahle, Jennifer M., additional
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- 2020
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28. Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma
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Miklja, Zachary, primary, Yadav, Viveka Nand, additional, Cartaxo, Rodrigo T., additional, Siada, Ruby, additional, Thomas, Chase C., additional, Cummings, Jessica R., additional, Mullan, Brendan, additional, Stallard, Stefanie, additional, Paul, Alyssa, additional, Bruzek, Amy K., additional, Wierzbicki, Kyle, additional, Yang, Tao, additional, Garcia, Taylor, additional, Wolfe, Ian, additional, Leonard, Marcia, additional, Robertson, Patricia L., additional, Garton, Hugh J.L., additional, Wahl, Daniel R., additional, Parmar, Hemant, additional, Sarkaria, Jann N., additional, Kline, Cassie, additional, Mueller, Sabine, additional, Nicolaides, Theodore, additional, Glasser, Chana, additional, Leary, Sarah E.S., additional, Venneti, Sriram, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul M., additional, Mody, Rajen, additional, Pai, Manjunath P., additional, Phoenix, Timothy N., additional, Marini, Bernard L., additional, and Koschmann, Carl, additional
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- 2020
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29. PDCT-12. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA
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Rahman Kawakibi, Abed, primary, Gardner, Sharon, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, DeGroot, John, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Umemura, Yoshie, additional, Schwartz, Jonathan, additional, Yadav, Vivekanand, additional, Cartaxo, Rodrigo, additional, Miklja, Zachary, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Mullan, Brendan, additional, Stallard, Stefanie, additional, Muruganand, Ashwath, additional, Wierzbicki, Kyle, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Kumar-Sinha, Chandan, additional, Marini, Bernard, additional, Leonard, Marcia, additional, Garton, Hugh, additional, Mody, Rajen, additional, Robertson, Patricia, additional, Merdinger, Krystal, additional, Tarapore, Rohinton, additional, Oster, Wolfgang, additional, Allen, Joshua, additional, and Koschmann, Carl, additional
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- 2019
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30. PDTM-10. USE OF A NOVEL, HAND-HELD, ELECTRONIC DNA ANALYSIS PLATFORM TO QUANTIFY MULTI-GENE MOLECULAR RESPONSE IN CSF OF PATIENTS WITH HIGH-GRADE GLIOMA
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Bruzek, Amy, primary, Tunkle, Leo, additional, Babila, Clarissa, additional, Muruganand, Ashwath, additional, Stallard, Stefanie, additional, Thamilselvan, Veena, additional, Qin, Tingting, additional, Wolfe, Ian, additional, Mody, Rajen, additional, Robertson, Patricia, additional, Maher, Cormac, additional, Muraszko, Karin, additional, Garton, Hugh, additional, and Koschmann, Carl, additional
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- 2019
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31. Morphometric changes at the craniocervical junction during childhood
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Bapuraj, Jayapalli Rajiv, primary, Bruzek, Amy K., additional, Tarpeh, Jamaal K., additional, Pelissier, Lindsey, additional, Garton, Hugh J. L., additional, Anderson, Richard C. E., additional, Nan, Bin, additional, Ma, Tianwen, additional, and Maher, Cormac O., additional
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- 2019
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32. The effect of everolimus on CNS penetration and efficacy of dasatinib in the treatment of PDGFRA-driven glioma.
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Miklja, Zachary, primary, Mullan, Brendan, additional, Siada, Ruby, additional, Stallard, Stefanie, additional, Yadav, Viveka Nand, additional, Bruzek, Amy, additional, Garcia, Taylor, additional, Leonard, Marcia, additional, Robertson, Patricia, additional, Paul, Alyssa, additional, Pai, Manjunath, additional, Phoenix, Timothy, additional, Marini, Bernard, additional, and Koschmann, Carl Johannes, additional
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- 2019
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33. DIPG-06. RAPID, ULTRA-DEEP SEQUENCING OF PEDIATRIC DIPG FROM CEREBROSPINAL FLUID USING A NOVEL HAND-HELD ELECTRONIC DNA ANALYSIS PLATFORM
- Author
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Bruzek, Amy K, primary, Tunkle, Leo, additional, Stallard, Stefanie, additional, Thamilselvan, Veena, additional, Qin, Tingting, additional, Wolfe, Ian, additional, Mody, Rajen, additional, Muraszko, Karin L, additional, Robertson, Patricia L, additional, Maher, Cormac O, additional, Garton, Hugh J L, additional, and Koschmann, Carl, additional
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- 2019
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34. HGG-04. USE OF AN ADVANCED RNA-SEQ FUSION PIPELINE RESULTS IN THE TARGETED TREATMENT AND SUSTAINED CLINICAL RESPONSE OF CHILDREN WITH RECURRENT PEDIATRIC HIGH-GRADE GLIOMA
- Author
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Schwark, Kallen, primary, Bruzek, Amy, additional, Kumar-Sinha, Chandan, additional, Escolero, Sylvia, additional, Marini, Bernard, additional, Pasternak, Amy, additional, Leonard, Marcia, additional, Robertson, Patricia, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, and Koschmann, Carl, additional
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- 2019
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35. HGG-03. EVEROLIMUS TREATMENT IMPROVES THE CNS PENETRATION AND EFFICACY OF DASATINIB IN THE TREATMENT OF PDGFRA-DRIVEN PEDIATRIC HIGH-GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA
- Author
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Miklja, Zachary, primary, Mullan, Brendan, additional, Stallard, Stefanie, additional, Yadav, Viveka Nand, additional, Bruzek, Amy K, additional, Garcia, Taylor, additional, Leonard, Marcia, additional, Robertson, Patricia L, additional, Paul, Alyssa, additional, Pai, Manjunath P, additional, Phoenix, Timothy, additional, Marini, Bernard, additional, and Koschmann, Carl, additional
- Published
- 2019
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36. Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations
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Miklja, Zachary, primary, Pasternak, Amy, additional, Stallard, Stefanie, additional, Nicolaides, Theodore, additional, Kline-Nunnally, Cassie, additional, Cole, Bonnie, additional, Beroukhim, Rameen, additional, Bandopadhayay, Pratiti, additional, Chi, Susan, additional, Ramkissoon, Shakti H, additional, Mullan, Brendan, additional, Bruzek, Amy K, additional, Gauthier, Angela, additional, Garcia, Taylor, additional, Atchison, Christie, additional, Marini, Bernard, additional, Fouladi, Maryam, additional, Parsons, D William, additional, Leary, Sarah, additional, Mueller, Sabine, additional, Ligon, Keith L, additional, and Koschmann, Carl, additional
- Published
- 2019
- Full Text
- View/download PDF
37. PDTM-29. CSF H3F3A K27M CIRCULATING TUMOR DNA COPY NUMBER QUANTIFIES TUMOR GROWTH AND TREATMENT RESPONSE
- Author
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Stallard, Stefanie, primary, G. Savelieff, Masha, additional, Mullan, Brendan, additional, Miklja, Zachary, additional, Bruzek, Amy, additional, Garcia, Taylor, additional, Wierzbicki, Kyle, additional, Singer, Benjamin, additional, Hashizume, Rintaro, additional, Montero Carcaboso, Angel, additional, Q. McMurray, Kaitlin, additional, Heth, Jason, additional, Muraszko, Karin, additional, L. Robertson, Patricia, additional, Mody, Rajen, additional, Venneti, Sriram, additional, Garton, Hugh, additional, and Koschmann, Carl, additional
- Published
- 2018
- Full Text
- View/download PDF
38. The Preventable Shunt Revision Rate: A Multicenter Evaluation
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Dave, Pooja, primary, Venable, Garrett T, additional, Jones, Tamekia L, additional, Khan, Nickalus R, additional, Albert, Gregory W, additional, Chern, Joshua J, additional, Wheelus, Jennifer L, additional, Governale, Lance S, additional, Huntoon, Kristin M, additional, Maher, Cormac O, additional, Bruzek, Amy K, additional, Mangano, Francesco T, additional, Mehta, Vivek, additional, Beaudoin, Wendy, additional, Naftel, Robert P, additional, Basem, Jade, additional, Whitney, Anna, additional, Shimony, Nir, additional, Rodriguez, Luis F, additional, Vaughn, Brandy N, additional, and Klimo, Paul, additional
- Published
- 2018
- Full Text
- View/download PDF
39. Preventable Shunt Revision Rate: A Multicenter Evaluation.
- Author
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Dave, Pooja, Venable, Garrett T, Jones, Tamekia L, Khan, Nickalus R, Albert, Gregory W, Chern, Joshua J, Wheelus, Jennifer L, Governale, Lance S, Huntoon, Kristin M, Maher, Cormac O, Bruzek, Amy K, Mangano, Francesco T, Mehta, Vivek, Beaudoin, Wendy, Naftel, Robert P, Basem, Jade, Whitney, Anna, Shimony, Nir, Rodriguez, Luis F, and Vaughn, Brandy N
- Published
- 2019
- Full Text
- View/download PDF
40. Molecular characterization reveals NF1 deletions and FGFR1‐activating mutations in a pediatric spinal oligodendroglioma
- Author
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Bruzek, Amy K., primary, Zureick, Andrew H., additional, McKeever, Paul E., additional, Garton, Hugh J. L., additional, Robertson, Patricia L., additional, Mody, Rajen, additional, and Koschmann, Carl J., additional
- Published
- 2016
- Full Text
- View/download PDF
41. MPTH-21. MOLECULAR CHARACTERIZATION REVEALS NF1 LOSS AND FGFR1 ACTIVATING MUTATIONS IN PEDIATRIC SPINAL OLIGODENDROGLIOMA
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Bruzek, Amy K., primary, Zureick, Andrew, additional, Venneti, Sriram, additional, McKeever, Paul, additional, Garton, Hugh J.L., additional, Robertson, Patricia, additional, Mody, Rajen, additional, and Koschmann, Carl, additional
- Published
- 2016
- Full Text
- View/download PDF
42. Intramedullary and Extramedullary Cervical Neurenteric Cyst Requiring Fixation and Fusion
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Bruzek, Amy K., primary, Kucia, Elisa J., additional, and Oppenlander, Mark E., additional
- Published
- 2016
- Full Text
- View/download PDF
43. The Preventable Shunt Revision Rate: A Multicenter Evaluation
- Author
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Dave, Pooja, Venable, Garrett T, Jones, Tamekia L, Khan, Nickalus R, Albert, Gregory W, Chern, Joshua J, Wheelus, Jennifer L, Governale, Lance S, Huntoon, Kristin M, Maher, Cormac O, Bruzek, Amy K, Mangano, Francesco T, Mehta, Vivek, Beaudoin, Wendy, Naftel, Robert P, Basem, Jade, Whitney, Anna, Shimony, Nir, Rodriguez, Luis F, Vaughn, Brandy N, and Klimo, Paul
- Published
- 2019
- Full Text
- View/download PDF
44. Pilocytic Astrocytoma Presenting as an Orbital Encephalocele: A Case Report
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Bruzek, Amy, primary, Shepherd, Daniel, additional, Van Gompel, Jamie, additional, and Jentoft, Mark, additional
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- 2015
- Full Text
- View/download PDF
45. Molecular characterization reveals NF1 deletions and FGFR1-activating mutations in a pediatric spinal oligodendroglioma.
- Author
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Bruzek, Amy K., Zureick, Andrew H., McKeever, Paul E., Garton, Hugh J. L., Robertson, Patricia L., Mody, Rajen, and Koschmann, Carl J.
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- 2017
- Full Text
- View/download PDF
46. Syringomyelia in children with closed spinal dysraphism: long-term outcomes after surgical intervention.
- Author
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Bruzek AK, Starr J, Garton HJL, Muraszko KM, Maher CO, and Strahle JM
- Abstract
Objective: The nature of the relationship between spinal cord syrinx and tethered cord is not well known. It is unclear if surgical cord untethering results in resolution or improvement of an associated syrinx. The objective of this study was to report the response of spinal cord syrinx to surgical cord untethering., Methods: The authors retrospectively reviewed all patients with a syrinx and tethered cord who presented to a single institution over an 11-year interval. Patients with open neural tube defects were excluded. Thirty-one patients were identified, 25 of whom had both clinical and imaging follow-up after surgery. Patients were grouped according to etiology of the tethered cord. Clinical outcomes and syrinx characteristics were recorded., Results: Of the 25 patients with tethered cord, 68% (n = 17) were male. The average age at presentation was 2.5 years (0-10.1 years) and age at surgery was 3.7 years (range 1 day to 17 years). Etiologies of tethered cord were lipomyelomeningocele (n = 8), thickened/fatty filum (n = 7), intradural lipoma (n = 5), myelocystocele (n = 2), meningocele (n = 2), and diastematomyelia (n = 1). Twenty-three of the patients underwent primary untethering, whereas 2 patients had received untethering previously at another institution. The average syrinx length and width prior to surgery were 4.81 vertebral levels (SD 4.35) and 5.19 mm (SD 2.55 mm), respectively. Conus level ranged from L1 to S3. Patients were followed for an average of 8.4 years (1.35-15.85 years). Overall there was no significant change in syrinx length or width postoperatively; the average syrinx length increased by 0.86 vertebral levels (SD 4.36) and width decreased by 0.72 mm (SD 2.94 mm). Seven of 25 patients had improvement in at least one presenting symptom, including scoliosis, weakness, bowel/bladder dysfunction, and pain. Eight patients had stable presenting symptoms. Six patients were asymptomatic and 5 patients had new or worsening symptoms, which included scoliosis, pain, or sensory changes., Conclusions: Although some syrinxes improved after surgery for tethered cord, radiological improvement was not consistent and did not appear to be associated with change in clinical symptoms. The decision to surgically untether a cord should be focused on the clinical symptoms and not the presence of a syrinx alone. Further studies are needed to confirm this finding.
- Published
- 2019
- Full Text
- View/download PDF
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