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Your search keyword '"Brustle, Oliver"' showing total 5 results
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5 results on '"Brustle, Oliver"'

1. GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Author

Wolf, Christina, primary, Pouya, Alireza, additional, Bitar, Sara, additional, Pfeiffer, Annika, additional, Bueno, Diones Caeran, additional, Arndt, Sabine, additional, Tenzer, Stefan, additional, Ritz, Sandra, additional, Schwirz, Jonas, additional, Dobrindt, Kristina, additional, Peitz, Michael, additional, Brustle, Oliver, additional, Bello, Federica Dal, additional, Vianello, Caterina, additional, Giacomello, Marta, additional, Hanschmannn, Eva-Maria, additional, Boussaad, Ibrahim, additional, Krüger, Rejko, additional, and Methner, Axel, additional

Published
2021
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2. Identification of APOE phenotypes in microglia and neurons derived from isogenic hips cells: A study of the IMI ADAPTED consortium

Author

Bahnassawy, Lamiaa, primary, Buchheit, Johanna, additional, Curado, Marco Rocha, additional, Ried, Janina S., additional, Sáez, María Eugenia, additional, Nicolas, Armel, additional, Rao, Francesco, additional, Kaplan, Charlotte, additional, Mohler, Eric G., additional, Lee, Heyne, additional, Untucht, Christopher, additional, Korffmann, Juergen, additional, Lakics, Viktor, additional, Cik, Miroslav, additional, Grezella, Clara, additional, Brustle, Oliver, additional, Peitz, Michael, additional, Mañes, Santos, additional, Ramaswamy, Gayathri, additional, Socorro, Alfredo Cabrera, additional, Bakker, Margot H.M., additional, and Reinhardt, Peter, additional

Published
2020
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3. Modelling AD‐relevant pathophysiology in neurons, astrocytes and microglia from two complete sets of isogenic iPSC lines generated by the ADAPTED project

Author

Socorro, Alfredo Cabrera, primary, Schmid, Benjamin, additional, Clausen, Christian, additional, Holst, Bjørn, additional, Peitz, Michael, additional, Grezella, Clara, additional, Brustle, Oliver, additional, Bahnassawy, Lamiaa, additional, Bennett, Keiryn, additional, Ried, Janina S., additional, Sáez, María Eugenia, additional, Ramaswamy, Gayathri, additional, Ruiz, Agustin, additional, Bakker, Margot H.M., additional, Vicario, Carlos, additional, Lourenco, Teresa Silva, additional, and Reinhardt, Peter, additional

Published
2020
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4. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

Author

Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Jaenisch, Rudolf, Brennand, Kristen J., Marchetto, M. Carol, Benvenisty, Nissim, Brustle, Oliver, Ebert, Allison, Izpisua Belmonte, Juan Carlos, Kaykas, Ajamete, Lancaster, Madeline A., Livesey, Frederick J., McConnell, Michael J., McKay, Ronald D., Morrow, Eric M., Muotri, Alysson R., Panchision, David M., Rubin, Lee L., Sawa, Akira, Soldner, Frank, Song, Hongjun, Studer, Lorenz, Temple, Sally, Vaccarino, Flora M., Wu, Jun, Vanderhaeghen, Pierre, Gage, Fred H., Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Jaenisch, Rudolf, Brennand, Kristen J., Marchetto, M. Carol, Benvenisty, Nissim, Brustle, Oliver, Ebert, Allison, Izpisua Belmonte, Juan Carlos, Kaykas, Ajamete, Lancaster, Madeline A., Livesey, Frederick J., McConnell, Michael J., McKay, Ronald D., Morrow, Eric M., Muotri, Alysson R., Panchision, David M., Rubin, Lee L., Sawa, Akira, Soldner, Frank, Song, Hongjun, Studer, Lorenz, Temple, Sally, Vaccarino, Flora M., Wu, Jun, Vanderhaeghen, Pierre, and Gage, Fred H.

Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

Published
2016

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