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3. Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets

Author

Bouska, Alyssa, Bi, Chengfeng, Lone, Waseem, Zhang, Weiwei, Kedwaii, Ambreen, Heavican, Tayla, Lachel, Cynthia M., Yu, Jiayu, Ferro, Roberto, Eldorghamy, Nanees, Greiner, Timothy C., Vose, Julie, Weisenburger, Dennis D., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Jaffe, Elaine S., Braziel, Rita M., Siebert, Reiner, Miles, Rodney R., Dave, Sandeep, Reddy, Anupama, Delabie, Jan, Staudt, Louis M., Song, Joo Y., McKeithan, Timothy W., Fu, Kai, Green, Michael, Chan, Wing C., and Iqbal, Javeed

Published
2017
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4. Supplementary Fig. 3 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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5. Supplementary Fig. 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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6. Supplementary Table 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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7. Supplementary Fig. 5 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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8. Supplementary Fig. 4 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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9. Supplementary Table 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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10. Data from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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11. Supplementary Fig. 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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12. Data from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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13. CCR Translation for the Article from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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14. Supplementary Figure 1 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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15. CCR Translation for This Article from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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16. Supplementary Table 1 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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17. Supplementary Table 2 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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18. Supplementary Figure Legends 1-3, Tables 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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19. Supplementary Figures 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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20. Supplementary Data from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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21. Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

Author

Iqbal, Javeed, Shen, Yulei, Huang, Xin, Liu, Yanyan, Wake, Laura, Liu, Cuiling, Deffenbacher, Karen, Lachel, Cynthia M., Wang, Chao, Rohr, Joseph, Guo, Shuangping, Smith, Lynette M., Wright, George, Bhagavathi, Sharathkumar, Dybkaer, Karen, Fu, Kai, Greiner, Timothy C., Vose, Julie M., Jaffe, Elaine, Rimsza, Lisa, Rosenwald, Andreas, Ott, German, Delabie, Jan, Campo, Elias, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Armitage, James O., Weisenburger, Dennis D., Staudt, Louis M., Gascoyne, Randy D., McKeithan, Timothy W., and Chan, Wing C.

Published
2015
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22. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Author

Muppidi, Jagan R., Schmitz, Roland, Green, Jesse A., Xiao, Wenming, Larsen, Adrien B., Braun, Sterling E., An, Jinping, Xu, Ying, Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Dennis D., Chan, Wing C., Vaidehi, Nagarajan, Staudt, Louis M., and Cyster, Jason G.

Subjects
Genetic research, Lymphomas -- Genetic aspects, B cells -- Physiological aspects, Cancer -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined (1,2). Work in mice showed that sphingosine-l-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells (3,4). Recent deep sequencing studies of GCB-DLBCL have revealed mutations in many genes in this cancer, including in GNA13 (encoding Gα13) and S1PR2 (refs 5-7). Here we show, using in vitro and in vivo assays, that GCBDLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor's Akt and migration inhibitory functions. Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. Germinal centre B cells, unlike most lymphocytes, are tightly confined in lymphoid organs and do not recirculate. Remarkably, deficiency in Gα13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and blood. GCB-DLBCL cell lines frequently carried mutations in the Gα13 effector ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination. The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13. These findings identify a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma., We sequenced the S1PR2 coding region in 117 GCB-DLBCL, 31 Burkitt's lymphoma and 68 activated B-cell-like (ABC)-DLBCL samples. Twelve S1PR2 coding mutations were identified in the GCB-DLBCL samples versus one [...]

Published
2014

23. MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma

Author

Ramis-Zaldivar, Joan Enric, primary, Gonzalez-Farre, Blanca, additional, Nicolae, Alina, additional, Pack, Svetlana, additional, Clot, Guillem, additional, Nadeu, Ferran, additional, Mottok, Anja, additional, Horn, Heike, additional, Song, Joo Y, additional, Fu, Kai, additional, Wright, George, additional, Gascoyne, Randy D., additional, Chan, Wing C., additional, Scott, David W., additional, Feldman, Andrew L., additional, Valera, Alexandra, additional, Enjuanes, Anna, additional, Braziel, Rita M., additional, Smeland, Erlend B., additional, Staudt, Louis M., additional, Rosenwald, Andreas, additional, Rimsza, Lisa M., additional, Ott, German, additional, Jaffe, Elaine S, additional, Salaverria, Itziar, additional, and Campo, Elias, additional

Published
2021
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25. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens

Author

Mottok, Anja, Wright, George, Rosenwald, Andreas, Ott, German, Ramsower, Colleen, Campo, Elias, Braziel, Rita M., Delabie, Jan, Weisenburger, Dennis D., Song, Joo Y., Chan, Wing C., Cook, James R., Fu, Kai, Greiner, Tim, Smeland, Erlend, Holte, Harald, Savage, Kerry J., Glinsmann-Gibson, Betty J., Gascoyne, Randy D., Staudt, Louis M., Jaffe, Elaine S., Connors, Joseph M., Scott, David W., Steidl, Christian, and Rimsza, Lisa M.

Published
2018
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26. Intraclonal Heterogeneity Caused By Activation-Induced Cytidine Deaminase Is Not a Prognostic Biomarker in Untreated Advanced Stage Follicular Lymphoma: An Analysis of SWOG S0016

Author

Burack, Richard, primary, Li, Hongli, additional, Adlowitz, Diana G, additional, Spence, Janice M, additional, Leblanc, Michael L., additional, Rimsza, Lisa M., additional, Braziel, Rita M., additional, Spier, Catherine M., additional, Kaminski, Mark S, additional, Leonard, John P., additional, Fisher, Richard I., additional, Smith, Sonali M., additional, and Friedberg, Jonathan W., additional

Published
2019
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27. Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

Author

Heavican, Tayla B., primary, Bouska, Alyssa, additional, Yu, Jiayu, additional, Lone, Waseem, additional, Amador, Catalina, additional, Gong, Qiang, additional, Zhang, Weiwei, additional, Li, Yuping, additional, Dave, Bhavana J., additional, Nairismägi, Maarja-Liisa, additional, Greiner, Timothy C., additional, Vose, Julie, additional, Weisenburger, Dennis D., additional, Lachel, Cynthia, additional, Wang, Chao, additional, Fu, Kai, additional, Stevens, Jadd M., additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Gascoyne, Randy D., additional, Missiaglia, Edoardo, additional, Lemonnier, Francois, additional, Haioun, Corinne, additional, Hartmann, Sylvia, additional, Pedersen, Martin Bjerregård, additional, Laginestra, Maria Antonella, additional, Wilcox, Ryan A., additional, Teh, Bin Tean, additional, Yoshida, Noriaki, additional, Ohshima, Koichi, additional, Seto, Masao, additional, Rosenwald, Andreas, additional, Ott, German, additional, Campo, Elias, additional, Rimsza, Lisa M., additional, Jaffe, Elaine S., additional, Braziel, Rita M., additional, d’Amore, Francesco, additional, Inghirami, Giorgio, additional, Bertoni, Francesco, additional, de Leval, Laurence, additional, Gaulard, Philippe, additional, Staudt, Louis M., additional, McKeithan, Timothy W., additional, Pileri, Stefano, additional, Chan, Wing C., additional, and Iqbal, Javeed, additional

Published
2019
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28. Subclonal Mutations of TP53 Are Common in Untreated Follicular Lymphoma and Mutation Status Is Predictive of PFS When CHOP Is Combined with 131-Iodine Tositumomab but Not with Rituximab: An Analysis of SWOG S0016

Author

Burack, Richard, primary, Li, Hongli, additional, Spence, Janice M, additional, Adlowitz, Diana, additional, Rimsza, Lisa M., additional, Braziel, Rita M., additional, Spier, Catherine M., additional, Kaminski, Mark S, additional, Leonard, John P., additional, Fisher, Richard I., additional, Leblanc, Michael L., additional, Smith, Sonali M., additional, and Friedberg, Jonathan W., additional

Published
2018
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29. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016

Author

Shadman, Mazyar, primary, Li, Hongli, additional, Rimsza, Lisa, additional, Leonard, John P., additional, Kaminski, Mark S., additional, Braziel, Rita M., additional, Spier, Catherine M., additional, Gopal, Ajay K., additional, Maloney, David G., additional, Cheson, Bruce D., additional, Dakhil, Shaker, additional, LeBlanc, Michael, additional, Smith, Sonali M., additional, Fisher, Richard I., additional, Friedberg, Jonathan W., additional, and Press, Oliver W., additional

Published
2018
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30. Impact of histological grading on survival in the SWOG S0016 follicular lymphoma cohort

Author

Rimsza, Lisa M., primary, Li, Hongli, additional, Braziel, Rita M., additional, Spier, Catherine M., additional, Persky, Daniel O., additional, Dunlap, Jennifer, additional, LeBlanc, Michael, additional, Bartlett, Nancy, additional, Leonard, John P., additional, Smith, Sonali M., additional, Press, Oliver W., additional, and Friedberg, Jonathan W., additional

Published
2018
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33. Comprehensive Genomic Analysis of Adult Burkitt Lymphoma Identifies the B-Cell Receptor Signaling Pathway As a Potential Therapeutic Target

Author

Bouska, Alyssa, primary, Bi, Chengfeng, additional, Lone, Waseem, additional, Zhang, Weiwei, additional, Kedwaii, Ambreen, additional, Heavican, Tayla B, additional, Lachel, Cynthia M, additional, Yu, Jiayu, additional, Fu, Kai, additional, Ferro, Roberto A., additional, Eldorghamy, Nanees, additional, Greiner, Timothy C., additional, Vose, Julie M, additional, Weisenburger, Dennis D, additional, Gascoyne, Randy D, additional, Rosenwald, Andreas, additional, Ott, German, additional, Campo, Elias, additional, Rimsza, Lisa M, additional, Jaffe, Elaine S., additional, Braziel, Rita M, additional, Siebert, Reiner, additional, Miles, Rodney R., additional, Dave, Sandeep, additional, Reddy, Anupama, additional, McKeithan, Timothy W., additional, Staudt, Louis M., additional, Green, Michael R, additional, Chan, Wing Chung, additional, and Iqbal, Javeed, additional

Published
2016
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34. Molecular Subgroups of Peripheral T-Cell Lymphoma Evolve By Distinct Genetic Pathways

Author

Heavican, Tayla B, primary, Yu, Jiayu, additional, Bouska, Alyssa, additional, Greiner, Timothy C, additional, Lachel, Cynthia M, additional, Wang, Chao, additional, Dave, Bhavana J, additional, Amador, Catalina C, additional, Fu, Kai, additional, Vose, Julie M, additional, Weisenburger, Dennis D, additional, Gascoyne, Randy D, additional, Hartmann, Sylvia, additional, Pedersen, Martin Bjerregård, additional, Wilcox, Ryan, additional, Teh, Bin Tean, additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Seto, Masao, additional, Berger, Francoise, additional, Rosenwald, Andreas, additional, Ott, German, additional, Campo, Elias, additional, Rimsza, Lisa M, additional, Jaffe, Elaine S., additional, Braziel, Rita M, additional, d'Amore, Francesco A, additional, Inghirami, Giorgio, additional, Bertoni, Francesco, additional, Staudt, Louis, additional, McKeithan, Timothy W., additional, Pileri, Stefano A, additional, Chan, Wing Chung, additional, and Iqbal, Javeed, additional

Published
2016
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35. Continued Excellent Outcomes in Previously Untreated Follicular Lymphoma Patients after Treatment with CHOP Plus Rituximab or CHOP Plus (131) Iodine-Tositumomab - Long Term Follow-up of Phase III Randomized Study SWOG S0016

Author

Shadman, Mazyar, primary, Li, Hongli, additional, Rimsza, Lisa, additional, Leonard, John P., additional, Kaminski, Mark S, additional, Braziel, Rita M, additional, Spier, Catherine M., additional, Gopal, Ajay K, additional, Maloney, David G, additional, Cheson, Bruce, additional, Dakhil, Shaker, additional, LeBlanc, Michael, additional, Smith, Sonali M., additional, Fisher, Richard I., additional, Friedberg, Jonathan W., additional, and Press, Oliver, additional

Published
2016
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37. Analytical Performance of Nanostring's Companion Diagnostic (CDx) Lymphoma Subtyping Test (LST) with Diffuse Large B-Cell Lymphoma Core Needle Biopsy Samples

Author

Storhoff, James, primary, Wallden, Brett, additional, Braziel, Rita M., additional, Thieblemont, Catherine, additional, Hood, Tressa, additional, Ravi, Harini, additional, Dennis, Shannon, additional, Dowidar, Naeem, additional, Danaher, Patrick, additional, Dunlap, Jennifer, additional, Briere, Josette, additional, de Kerviler, Eric, additional, and Ferree, Sean, additional

Published
2015
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38. Outcomes of DA-EPOCH-R induction plus autologous transplant consolidation for double hit lymphoma.

Author

Chen, Andy I., Leonard, Jessica T., Okada, Craig Y., Gay, Nathan D., Stentz, Alex, Maziarz, Richard T., Chansky, Kari, Fan, Guang, Dunlap, Jennifer B., Raess, Philipp W., and Braziel, Rita M.

Subjects
B cells, AUTOGRAFTS, LYMPHOMAS, CYCLOPHOSPHAMIDE, BURKITT'S lymphoma
Abstract

High-grade B cell lymphoma with MYC and BCL2 rearrangements (double hit) has a poor prognosis with standard R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). We report here a treatment algorithm of DA-EPOCH-R (dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab) followed by BEAM (carmustine, etoposide, cytarabine, melphalan) autologous transplant in 36 cases of previously untreated double hit lymphoma (DHL) from 2010 to 2015. A high risk International Prognostic Index (IPI) was present in 42% of cases. At median follow-up of 38 months, the 2-year progression free survival (PFS) and overall survival (OS) were 69% (95% CI 54-84%) and 71% (95% CI 56-86%). Eight cases were refractory to induction with 1-year OS 20%, and no factors were predictive for primary refractory disease. Of 28 responders, 17 proceeded to transplant while 11 were observed, primarily due to age and co-morbidities. By 24-week landmark analysis after diagnosis, the 2-year PFS and OS were both 94% (95% CI 83-100%) vs 79% (95% CI 52-100%) for transplant vs observation (p = .59 for both PFS and OS). There was no significant benefit to consolidative transplant in our series, and primary refractory DHL needs novel approaches. [ABSTRACT FROM AUTHOR]

Published
2018
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39. MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes.

Author

Raess, Philipp W., Moore, Stephen R., Cascio, Michael J., Dunlap, Jennifer, Fan, Guang, Gatter, Ken, Olson, Susan B., and Braziel, Rita M.

Subjects
B cell lymphoma, IMMUNOHISTOCHEMISTRY, HODGKIN'S disease, CYTOGENETICS, MOLECULAR genetics
Abstract

Accurate subclassification of aggressive B cell lymphomas (ABCLs) requires integration of morphologic, immunohistochemical (IHC), and cytogenetic information. Optimal strategies have not been well defined for diagnosis of high grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBLwR) and double expressor lymphomas with MYC and BCL2 protein overexpression. One hundred and eighty seven ABCLs were investigated with complete IHC and FISH analysis. Morphologic and IHC analysis was insufficient to identify clinically relevant HGBLwR. Approximately, 75% of cases classified as HGBLwR showed conventional DLBCL morphologic features. Fourteen percent of MYC-rearranged cases were negative by IHC. Conversely, 60% of cases positive for MYC by IHC did not demonstrate a MYC rearrangement. Analysis by FISH without MYC and BCL2 IHC would miss 41 cases of double expressor lymphoma. Complete IHC and FISH analysis is recommended in the evaluation of all ABCLs. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016.

Author

Shadman, Mazyar, Li, Hongli, Rimsza, Lisa, Leonard, John P., Kaminski, Mark S., Braziel, Rita M., Spier, Catherine M., Gopal, Ajay K., Maloney, David G., Cheson, Bruce D., Dakhil, Shaker, LeBlanc, Michael, Smith, Sonali M., Fisher, Richard I., Friedberg, Jonathan W., and Press, Oliver W.

Published
2018
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42. Diffuse large B-cell lymphoma cell-of-origin classification using the Lymph2Cx assay in the context of BCL2 and MYC expression status

Author

Kendrick, Samantha, primary, Tus, Katalin, additional, Wright, George, additional, Jaffe, Elaine S., additional, Rosenwald, Andreas, additional, Campo, Elías, additional, Chan, Wing Chung, additional, Connors, Joseph M., additional, Braziel, Rita M., additional, Ott, German, additional, Delabie, Jan, additional, Cook, James R., additional, Weisenburger, Dennis D., additional, Greiner, Timothy C., additional, Fu, Kai, additional, Staudt, Louis M., additional, Gascoyne, Randy D., additional, Scott, David W., additional, and Rimsza, Lisa M., additional

Published
2015
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43. Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling

Author

Yuan, Ji, primary, Wright, George, additional, Rosenwald, Andreas, additional, Steidl, Christian, additional, Gascoyne, Randy D., additional, Connors, Joseph M., additional, Mottok, Anja, additional, Weisenburger, Dennis D., additional, Greiner, Timothy C., additional, Fu, Kai, additional, Smith, Lynette, additional, Rimsza, Lisa M., additional, Jaffe, Elaine S., additional, Campo, Elias, additional, Martinez, Antonio, additional, Delabie, Jan, additional, Braziel, Rita M., additional, Cook, James R., additional, Ott, German, additional, Vose, Julie M., additional, Staudt, Louis M., additional, and Chan, Wing C., additional

Published
2015
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45. Cell-of-Origin Subtype Classification of Diffuse Large B-Cell Lymphoma Using the Lymph2Cx Assay Retains Relevance in the Context of BCL2 and MYC Expression Status

Author

Kendrick, Samantha L., primary, Tus, Katalin, additional, Scott, David W., additional, Wright, George, additional, Jaffe, Elaine S., additional, Rosenwald, Andreas, additional, Campo, Elías, additional, Chan, Wing Chung, additional, Connors, Joseph M., additional, Braziel, Rita M., additional, Ott, German, additional, Delabie, Jan, additional, Cook, James R., additional, Weisenburger, Dennis D., additional, Greiner, Timothy C., additional, Fu, Kai, additional, Staudt, Louis M., additional, Gascoyne, Randy D., additional, and Rimsza, Lisa M., additional

Published
2014
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46. Accurate Diagnosis of Aggressive B Cell Non-Hodgkin Lymphomas Using Gene Expression Profiling of Formalin-Fixed, Paraffin-Embedded Tissues

Author

Scott, David W., primary, Wright, George W., additional, Williams, Mickey, additional, Lih, Jason, additional, Jaffe, Elaine S., additional, Rosenwald, Andreas, additional, Campo, Elias, additional, Chan, Wing (John) C, additional, Connors, Joseph M., additional, Smeland, Erlend, additional, Braziel, Rita M., additional, Ott, German, additional, Delabie, Jan, additional, Weisenburger, Dennis D., additional, Cook, James R., additional, Greiner, Timothy C., additional, Fu, Kai, additional, Walsh, William, additional, Gascoyne, Randy D., additional, Staudt, Louis M., additional, and Rimsza, Lisa M., additional

Published
2014
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47. New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies.

Author

Scott, David W., Abrisqueta, Pau, Wright, George W., Slack, Graham W., Mottok, Anja, Villa, Diego, Jares, Pedro, Rauert-Wunderlich, Hilka, Royo, Cristina, Clot, Guillem, Pinyol, Magda, Boyle, Merrill, Fong Chun Chan, Braziel, Rita M., Chan, Wing C., Weisenburger, Dennis D., Cook, James R., Greiner, Timothy C., Fu, Kai, and Ott, German

Published
2017
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48. Diffuse large B-cell lymphoma cell-of-origin classification using the Lymph2Cx assay in the context of BCL2 and MYC expression status.

Author

Kendrick, Samantha, Tus, Katalin, Wright, George, Jaffe, Elaine S., Rosenwald, Andreas, Campo, Elías, Chan, Wing Chung, Connors, Joseph M., Braziel, Rita M., Ott, German, Delabie, Jan, Cook, James R., Weisenburger, Dennis D., Greiner, Timothy C., Fu, Kai, Staudt, Louis M., Gascoyne, Randy D., Scott, David W., and Rimsza, Lisa M.

Subjects
GENE expression, DIFFUSE large B-cell lymphomas
Abstract

A letter to the editor is presented on the use of Lymph2Cx assay, digital gene expression, to diffuse large B-cell lymphoma (DLBCL) cell-of-origin (COO) classification.

Published
2016
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49. Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling.

Author

Ji Yuan, Wright, George, Rosenwald, Andreas, Steidl, Christian, Gascoyne, Randy D., Connors, Joseph M., Mottok, Anja, Weisenburger, Dennis D., Greiner, Timothy C., Kai Fu, Smith, Lynette, Rimsza, Lisa M., Jaffe, Elaine S., Campo, Elias, Martinez, Antonio, Delabie, Jan, Braziel, Rita M., Cook, James R., Ott, German, and Vose, Julie M.

Published
2015
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50. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131 I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016.

Author

Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, and Press OW

Subjects
Antibodies, Monoclonal, Murine-Derived therapeutic use, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Cause of Death, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Doxorubicin administration & dosage, Doxorubicin therapeutic use, Female, Follow-Up Studies, Humans, Lymphoma, Follicular mortality, Male, Middle Aged, Neoplasms, Second Primary epidemiology, Prednisone administration & dosage, Prednisone therapeutic use, Prognosis, Rituximab, Vincristine administration & dosage, Vincristine therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lymphoma, Follicular drug therapy, Radioimmunotherapy methods
Abstract

Purpose SWOG S0016 was a phase III randomized study that compared the safety and efficacy of R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) with CHOP-RIT (CHOP followed by consolidation with iodine-133-tositumomab radioimmunotherapy) for previously untreated patients with follicular lymphoma. Understanding the long-term outcome of patients provides a benchmark for novel treatment regimens for FL. Patients and Methods Between 2001 and 2008, 531 previously untreated patients with FL were randomly assigned to receive either six cycles of R-CHOP or six cycles of CHOP-RIT. Patients with advanced-stage disease (bulky stage II, III, or IV) of any pathologic grade (1, 2, or 3) were eligible. Results After a median follow-up of 10.3 years, 10-year estimates of progression-free and overall survival were 49% and 78% among all patients, respectively. Patients in the CHOP-RIT arm had significantly better 10-year progression-free survival compared with patients in the R-CHOP arm (56% v 42%; P = .01), but 10-year overall survival was not different between the two arms (75% v 81%; P = .13). There was no significant difference between the CHOP-RIT and R-CHOP arms in regard to incidence of second malignancies (15.1% v 16.1%; P = .81) or myelodysplastic syndrome or acute myeloid leukemia (4.9% v 1.8%; P = .058). The estimated 10-year cumulative incidences of death resulting from second malignancies were not different (7.1% v 3.2%; P = .16), but cumulative incidence of death resulting from myelodysplastic syndrome or acute myeloid leukemia was higher in the CHOP-RIT arm compared with the R-CHOP arm (4% v 0.9%; P = .02). Conclusion Given these outstanding outcomes, immunochemotherapy should remain the standard induction approach for patients with high-risk FL until long-term follow-up of alternative approaches demonstrates superiority.

Published
2018
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