124 results on '"Boyer, Eric"'
Search Results
2. Correction to: Does Gender Influence Leadership Styles? A View from the U.S. Nonprofit Sector
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Boyer, Eric J., Reid, Rebecca, and Patton, Dana
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- 2023
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3. Why modify or terminate contracts for critical supplies? Evaluating federal purchasing of PPE following COVID-19.
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Boyer, Eric J., Rogers, Juan D., and Spampinato, Francis C.
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Contract managers change contracts to respond to unforeseen events and to improve the likelihood of securing critical supplies. This study employs data from the General Service Administration's SAM.gov Data Bank on over 8,000 contracts to examine the prevalence, reasons for, and timing of contract modifications and terminations in federal purchasing of personal protective equipment (PPE) in the first year of the COVID-19 public health crisis. Results show that modifications that transform transactional contracts to more collaborative designs were utilized for some of the highest-risk contracts and were associated with increased obligations, indicating that collaborative designs led to more purchasing of PPE. Competitive selection increased the likelihood of termination, the rate at which terminations occurred, and deobligations, indicating that the approach increased the costs of administration without improving the likelihood of securing supplies. A substantial portion of modifications and terminations occurred within the first forty days of delivery, revealing how contract management capacity was needed in the early stages of critical supply acquisition. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Discovery of stimulation-responsive immune enhancers with CRISPR activation
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Simeonov, Dimitre R, Gowen, Benjamin G, Boontanrart, Mandy, Roth, Theodore L, Gagnon, John D, Mumbach, Maxwell R, Satpathy, Ansuman T, Lee, Youjin, Bray, Nicolas L, Chan, Alice Y, Lituiev, Dmytro S, Nguyen, Michelle L, Gate, Rachel E, Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M, Mitros, Therese, Ray, Graham J, Curie, Gemma L, Naddaf, Nicki, Chu, Julia S, Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R, Schumann, Kathrin, Daly, Mark J, Farh, Kyle K, Ansel, K Mark, Ye, Chun J, Greenleaf, William J, Anderson, Mark S, Bluestone, Jeffrey A, Chang, Howard Y, Corn, Jacob E, and Marson, Alexander
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Biological Sciences ,Biomedical and Clinical Sciences ,Immunology ,Human Genome ,Genetics ,Autoimmune Disease ,Animals ,Antigens ,CD ,Antigens ,Differentiation ,T-Lymphocyte ,Autoimmunity ,CRISPR-Cas Systems ,Cell Differentiation ,Cell Line ,Chromatin ,Clustered Regularly Interspaced Short Palindromic Repeats ,Enhancer Elements ,Genetic ,Female ,Gene Expression Regulation ,Humans ,Interleukin-2 Receptor alpha Subunit ,Lectins ,C-Type ,Mice ,Receptors ,Antigen ,T-Cell ,Th17 Cells ,General Science & Technology - Abstract
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and their biological contexts is required to understand the mechanisms by which variation in non-coding genetic sequences contributes to disease. Functional enhancers can be mapped by genomic sequence disruption, but this approach is limited to the subset of enhancers that are necessary in the particular cellular context being studied. We hypothesized that recruitment of a strong transcriptional activator to an enhancer would be sufficient to drive target gene expression, even if that enhancer was not currently active in the assayed cells. Here we describe a discovery platform that can identify stimulus-responsive enhancers for a target gene independent of stimulus exposure. We used tiled CRISPR activation (CRISPRa) to synthetically recruit a transcriptional activator to sites across large genomic regions (more than 100 kilobases) surrounding two key autoimmunity risk loci, CD69 and IL2RA. We identified several CRISPRa-responsive elements with chromatin features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours an autoimmunity risk variant. Using engineered mouse models, we found that sequence perturbation of the disease-associated Il2ra enhancer did not entirely block Il2ra expression, but rather delayed the timing of gene activation in response to specific extracellular signals. Enhancer deletion skewed polarization of naive T cells towards a pro-inflammatory T helper (TH17) cell state and away from a regulatory T cell state. This integrated approach identifies functional enhancers and reveals how non-coding variation associated with human immune dysfunction alters context-specific gene programs.
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- 2017
5. Modulation of ellipses drawing by sonification
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Boyer, Eric O., Bevilacqua, Frederic, Guigon, Emmanuel, Hanneton, Sylvain, and Roby-Brami, Agnes
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- 2020
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6. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
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Schumann, Kathrin, Lin, Steven, Boyer, Eric, Simeonov, Dimitre R, Subramaniam, Meena, Gate, Rachel E, Haliburton, Genevieve E, Ye, Chun J, Bluestone, Jeffrey A, Doudna, Jennifer A, and Marson, Alexander
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Biological Sciences ,Biomedical and Clinical Sciences ,Immunology ,Human Genome ,Genetics ,Biotechnology ,Bacterial Proteins ,CD4-Positive T-Lymphocytes ,Cell Line ,Clustered Regularly Interspaced Short Palindromic Repeats ,Electroporation ,Endonucleases ,Gene Knock-In Techniques ,Genetic Engineering ,Genome ,High-Throughput Nucleotide Sequencing ,Humans ,Leukocytes ,Mononuclear ,Receptors ,CXCR4 ,Ribonucleoproteins ,T-Lymphocytes ,CRISPR/Cas9 ,genome engineering ,Cas9 ribonucleoprotein ,RNP ,primary human T cells - Abstract
T-cell genome engineering holds great promise for cell-based therapies for cancer, HIV, primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T cells has been challenging. Improved tools are needed to efficiently "knock out" genes and "knock in" targeted genome modifications to modulate T-cell function and correct disease-associated mutations. CRISPR/Cas9 technology is facilitating genome engineering in many cell types, but in human T cells its efficiency has been limited and it has not yet proven useful for targeted nucleotide replacements. Here we report efficient genome engineering in human CD4(+) T cells using Cas9:single-guide RNA ribonucleoproteins (Cas9 RNPs). Cas9 RNPs allowed ablation of CXCR4, a coreceptor for HIV entry. Cas9 RNP electroporation caused up to ∼40% of cells to lose high-level cell-surface expression of CXCR4, and edited cells could be enriched by sorting based on low CXCR4 expression. Importantly, Cas9 RNPs paired with homology-directed repair template oligonucleotides generated a high frequency of targeted genome modifications in primary T cells. Targeted nucleotide replacement was achieved in CXCR4 and PD-1 (PDCD1), a regulator of T-cell exhaustion that is a validated target for tumor immunotherapy. Deep sequencing of a target site confirmed that Cas9 RNPs generated knock-in genome modifications with up to ∼20% efficiency, which accounted for up to approximately one-third of total editing events. These results establish Cas9 RNP technology for diverse experimental and therapeutic genome engineering applications in primary human T cells.
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- 2015
7. Responding to Environmental Uncertainties in Critical Supply Acquisition: An Examination of Contracting for Personal Protective Equipment (PPE) in the Aftermath of COVID-19.
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Boyer, Eric J
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PERSONAL protective equipment ,COVID-19 pandemic ,GOVERNMENT policy ,SUPPLY chain management ,CONTRACTORS - Abstract
While prior research has long identified the centrality of critical supply acquisition to the government's response to a crisis, there is less understanding of how to secure critical supplies that depend on global supply chains. The acquisition of personal protective equipment (PPE) in the immediate aftermath of the coronavirus disease 2019 outbreak (COVID-19) proved challenging not only due to threats of contractor deception but also due to disruptions in contractor supply chains. This research analyzes primary interview data with contracting officials involved in purchasing PPE in the early stages of the COVID-19 crisis. The results indicate the ways that contractor relationships were perceived useful in anticipating risks surrounding a contractor's behavior (behavioral uncertainties), but insufficient in anticipating disruptions that can result from a contractor's supply chains (environmental uncertainties). Contractor relations were perceived to help in predicting industry disruptions, but such relations were likely to be formed alongside transactional and short-term contract designs—and likely to require comparison with other data sources. The results indicate that improving the reliability of critical supply acquisition for future crises is likely to depend on developing expertise in supply chain analysis, especially as the U.S. government increasingly relies on global supply chains in critical supply acquisition. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Pre-exascale Architectures: OpenPOWER Performance and Usability Assessment for French Scientific Community
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Hautreux, Gabriel, Buttari, Alfredo, Beck, Arnaud, Cameo, Victor, Lecas, Dimitri, Aubert, Dominique, Brun, Emeric, Boyer, Eric, Malvagi, Fausto, Staffelbach, Gabriel, d’Ast, Isabelle, Legaux, Joeffrey, Lartigue, Ghislain, Grasseau, Gilles, Latu, Guillaume, Escobar, Juan, Bigot, Julien, Derouillat, Julien, Haefele, Matthieu, Renon, Nicolas, Parnaudeau, Philippe, Wautelet, Philippe, Lavallee, Pierre-Francois, Kestener, Pierre, Lacroix, Remi, Requena, Stephane, Scemama, Anthony, Moureau, Vincent, Etancelin, Jean-Matthieu, Meurdesoif, Yann, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Kunkel, Julian M., editor, Yokota, Rio, editor, Taufer, Michela, editor, and Shalf, John, editor
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- 2017
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9. VISTA is an acidic pH-selective ligand for PSGL-1
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Johnston, Robert J., Su, Linhui Julie, Pinckney, Jason, Critton, David, Boyer, Eric, Krishnakumar, Arathi, and Corbett, Martin
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T cells -- Physiological aspects -- Genetic aspects ,Ligands (Biochemistry) -- Physiological aspects -- Genetic aspects ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Co-inhibitory immune receptors can contribute to T cell dysfunction in patients with cancer.sup.1,2. Blocking antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) partially reverse this effect and are becoming standard of care in an increasing number of malignancies.sup.3. However, many of the other axes by which tumours become inhospitable to T cells are not fully understood. Here we report that V-domain immunoglobulin suppressor of T cell activation (VISTA) engages and suppresses T cells selectively at acidic pH such as that found in tumour microenvironments. Multiple histidine residues along the rim of the VISTA extracellular domain mediate binding to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1). Antibodies engineered to selectively bind and block this interaction in acidic environments were sufficient to reverse VISTA-mediated immune suppression in vivo. These findings identify a mechanism by which VISTA may engender resistance to anti-tumour immune responses, as well as an unexpectedly determinative role for pH in immune co-receptor engagement. V-domain immunoglobulin suppressor of T cell activation (VISTA) selectively engages P-selectin glycoprotein ligand-1 (PSGL-1) and suppresses T cells at acidic pH similar to those in tumour microenvironments, thereby mediating resistance to anti-tumour immune responses., Author(s): Robert J. Johnston [sup.1] , Linhui Julie Su [sup.2] , Jason Pinckney [sup.3] , David Critton [sup.4] , Eric Boyer [sup.1] , Arathi Krishnakumar [sup.5] , Martin Corbett [sup.6] [...]
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- 2019
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10. An Analysis of Federal Purchasing of Personal Protective Equipment in the Aftermath of COVID-19 (WITHDRAWN)
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Boyer, Eric, primary, Rogers, Juan, additional, and Spampinato, Frank, additional
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- 2023
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11. An Empirical Examination of Public Involvement in Public-Private Partnerships: Qualifying the Benefits of Public Involvement in PPPs
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Boyer, Eric J., Van Slyke, David M., and Rogers, Juan D.
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- 2016
12. Examining contract modifications in purchasing personal protective equipment: A bargaining approach
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Boyer, Eric J., primary and Faria, João Ricardo, additional
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- 2023
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13. High‐Pressure Combustion Studies of Energetic Materials
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Yetter, Richard A., primary and Boyer, Eric, additional
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- 2023
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14. Does Gender Influence Leadership Styles? A View from the U.S. Nonprofit Sector
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Boyer, Eric J., primary, Reid, Rebecca, additional, Studies, Graduate, additional, and Patton, Dana, additional
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- 2022
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15. Derisking Offshore Windfarm Installation by Sub-Seafloor Boulder Detection Based on Dedicated Seismic Diffraction Imaging
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Wenau, Stefan, primary, Schwarz, Benjamin, additional, Bihler, Viola, additional, Boyer, Eric, additional, and Preu, Benedict, additional
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- 2022
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16. Post traumatic deafness: a pictorial review of CT and MRI findings
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Maillot, Olivier, Attyé, Arnaud, Boyer, Eric, Heck, Olivier, Kastler, Adrian, Grand, Sylvie, Schmerber, Sébastien, and Krainik, Alexandre
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- 2016
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17. D6.1 In-kind systems description
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Boyer, Eric, Neveu, Florent, Gilliot, Maike, Gregori, Daniele, Vysocky, Ondrej, Bartolini, Andrea, and Aldinucci, Marco
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In-kind resources - Abstract
This document means to provide detailed descriptions of all systems made available in-kind by partners in their supercomputing centers to the EUPEX project. Overall, 6 partners provide system resources in-kind. The availability of the in-kind pilot systems as first phase is key to define the require-ments for the Exascale pilot architecture and characteristics. Relying on representative application profile analysis and co-design studies performed on the in-kind systems, WP3 will provide valuable inputs to both WP4 and WP5 in order to specify the Pilot hardware and software components. Applications porting, optimization and scaling tests will be done on these systems made available in-kind, based on state-of-the-art ARM technologies, innovative inter-connect, optionally connected to accelerated modules. Some systems although not based upon ARM, offer interesting features, which are exposed. In chapter 2, " In-kind resources as first stage towards the pilots for EUPEX partners", the key role of in-kind systems in the timeline project is reminded, as “beta” pilot sys-tems design (see figure 1), needs application and software stack requirements input. Phases of In-kind systems presentation and their role in the project are described. The descriptions given in chapter 3 “In-Kind systems for EUPEX project” cover hard-ware and software aspects, architecture, software ecosystem, integration and data or-ganisation, services, types and amount of resources available for the EUPEX project, explanation on process to get access (including security and authentication con-straints), and resources grant process. On top of this, two partners also provide OpenStack partitions and Gitlab services as in-kind contribution. These systems will provide annex support for EUPEX activities (cf. Section 4). IT4Innovations’s will provide GitLab services CEA’s OpenStack partition will host the OCEAN code repository as well as the EUPEX-internal ticketing system Users of EUPEX in-kind systems, mainly from WP3 and WP5, will find in this document a hand-book to identify the outcomes targeted for their assessment activities for co-design, and all the information to obtain resources and access. 
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- 2022
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18. Characterization and Detailed Analysis of Regression Behavior for HTPB Solid Fuels Containing High Aluminum Loadings
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Kibbey, Timothy P, Cortopassi, Andrew C, and Boyer, Eric C
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Propellants And Fuels - Abstract
NASA Marshall Space Flight Center's Materials and Processes Department, with support from the Propulsion Systems Department, has renewed the development and maintenance of a hybrid test bed for exposing ablative thermal protection materials to an environment similar to that seen in solid rocket motors (SRM). The Solid Fuel Torch (SFT), operated during the Space Shuttle program, utilized gaseous oxygen for oxidizer and an aluminized hydroxyl-terminated polybutadiene (HTPB) fuel grain to expose a converging section of phenolic material to a 400 psi, 2-phase flow combustion environment. The configuration allows for up to a 2 foot long, 5 inch diameter fuel grain cartridge. Wanting to now test rubber insulation materials with a turn-back feature to mimic the geometry of an aft dome being impinged by alumina particles, the throat area has now been increased by several times to afford flow similarity. Combined with the desire to maintain a higher operating pressure, the oxidizer flow rate is being increased by a factor of 10. Out of these changes has arisen the need to characterize the fuel/oxidizer combination in a higher mass flux condition than has been previously tested at MSFC, and at which the literature has little to no reporting as well. For (especially) metalized fuels, hybrid references have pointed out possible dependence of fuel regression rate on a number of variables: mass flux, G - oxidizer only (G0), or - total mass flux (Gtot), Length, L, Pressure, P, and Diameter, D.
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- 2017
19. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation
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Simeonov, Dimitre R., Gowen, Benjamin G., Boontanrart, Mandy, Roth, Theodore L., Gagnon, John D., Mumbach, Maxwell R., Satpathy, Ansuman T., Lee, Youjin, Bray, Nicolas L., Chan, Alice Y., Lituiev, Dmytro S., Nguyen, Michelle L., Gate, Rachel E., Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M., Mitros, Therese, Ray, Graham J., Curie, Gemma L., Naddaf, Nicki, Chu, Julia S., Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R., Schumann, Kathrin, Daly, Mark J., Farh, Kyle K., Ansel, K. Mark, Ye, Chun J., Greenleaf, William J., Anderson, Mark S., Bluestone, Jeffrey A., Chang, Howard Y., Corn, Jacob E., and Marson, Alexander
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- 2018
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20. Examining contract modifications in purchasing personal protective equipment: A bargaining approach.
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Boyer, Eric J. and Faria, João Ricardo
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- 2022
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21. Managing cross-sector collaboration
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Forrer, John J., Kee, James Edwin "Jed", and Boyer, Eric
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Employee selection -- Methods -- Forecasts and trends ,Public-private sector cooperation -- Management -- Forecasts and trends -- Evaluation ,Public officers -- Management -- Laws, regulations and rules ,Government regulation ,Hiring ,Company business management ,Market trend/market analysis ,Government - Abstract
Public managers can choose from four types of cross-sector collaboration. Here's a look into the tradeoffs of each type. Cross-sector collaboration (CSC) is becoming a more familiar fixture on the [...]
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- 2014
22. Medical Supply Acquisition in Italy and the United States in the Era of COVID-19: The Case for Strategic Procurement and Public–Private Partnerships
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Vecchi, Veronica, primary, Cusumano, Niccolò, additional, and Boyer, Eric J., additional
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- 2020
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23. Examining Gender Dimensions of Leadership in International Nonprofits
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Kolpakov, Aleksey, primary and Boyer, Eric, additional
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- 2020
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24. Continuous Auditory Feedback of Eye Movements: An Exploratory Study toward Improving Oculomotor Control
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Boyer, Eric, Portron, Arthur, Bevilacqua, Frédéric, Lorenceau, Jean, Interactions Son Musique Mouvement, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des systèmes perceptifs (LSP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Boyer, Eric
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eye movements ,smooth pursuit ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,voluntary oculomotor control ,auditory-motor learning ,sonification ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Original Research ,Neuroscience ,lcsh:RC321-571 - Abstract
International audience; As eye movements are mostly automatic and overtly generated to attain visual goals, individuals have a poor metacognitive knowledge of their own eye movements. We present an exploratory study on the effects of real-time continuous auditory feedback generated by eye movements. We considered both a tracking task and a production task where smooth pursuit eye movements (SPEM) can be endogenously generated. In particular, we used a visual paradigm which enables to generate and control SPEM in the absence of a moving visual target. We investigated whether real-time auditory feedback of eye movement dynamics might improve learning in both tasks, through a training protocol over 8 days. The results indicate that real-time sonification of eye movements can actually modify the oculomotor behavior, and reinforce intrinsic oculomotor perception. Nevertheless, large inter-individual differences were observed preventing us from reaching a strong conclusion on sensorimotor learning improvements.
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- 2017
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25. UNPACKING THE INFLUENCE OF PUBLIC–PRIVATE PARTNERSHIPS ON DISASTER RESILIENCE: A COMPARISON OF EXPERT PERSPECTIVES
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BOYER, Eric J., primary
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- 2019
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26. HIGH-PRESSURE BURNING RATE MEASUREMENTS BY DIRECT OBSERVATION
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Derk, Greg, primary, Risha, Grant A., additional, Boyer, Eric, additional, and Yetter, Richard A., additional
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- 2019
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27. Examining Gender Dimensions of Leadership in International Nonprofits.
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Kolpakov, Aleksey and Boyer, Eric
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WOMEN executives , *LEADERSHIP , *NONPROFIT organizations , *NONPROFIT sector , *GENDER - Abstract
Do male and female executives approach leadership in similar ways? What do their approaches reveal about their potentials for addressing contemporary leadership challenges and promoting leadership ascension? While considerable research has been conducted on the ways that gender influences leadership styles, the issue has received limited attention in the nonprofit sector. This research provides a unique perspective on the ways that male and female executives align their leadership approaches with gendered constructs of leadership outlined in the agentic-communal framework. The results indicate that while male and female leaders adhered to many aspects of the gendered domains of the framework, there were some notable exceptions. Female executives were generally more likely to adopt interpersonal approaches to leadership, and while common aspects of executive leadership reflected masculine constructs of leadership traits, male and female executives displayed more variance in their approaches to leadership skills and behaviors. [ABSTRACT FROM AUTHOR]
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- 2021
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28. DEVICE FOR IN VIVO SAMPLING OF BIOLOGICAL SPECIES
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Mombrun, Adrien, Bouamrani, Mohamed- Ali, Boyer, Eric, Yeromonahos, Christelle, yeromonahos, christelle, INL - Chimie et Nanobiotechnologies (INL - C&N), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry ,integumentary system ,genetic structures ,[PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] ,[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,sense organs ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] - Abstract
The invention relates to a device for in vivo sampling of biological species, comprising: a tubular sheath extending between a proximal end of said sheath and a distal end of said sheath, said distal end of the sheath having a projecting part, a rod extending between a proximal end of said rod and a distal end of said rod, capable of sliding in the sheath between a retracted position in which the distal end of the rod is located inside the sheath and a deployed position in which the distal end of the rod extends beyond the distal end of the sheath, said rod comprising a capturing support for capturing said biological species, made from a porous material, arranged in a distal region of the rod on a portion of the circumference of the rod such that the capturing support is located outside the sheath when the rod is in the deployed position of same.
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- 2017
29. Touching Sounds
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Boyer, Eric O, Vandervoorde, L, Bevilacqua, F, Hanneton, S, and Boyer, Eric
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auditory interaction ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,Sensory substitution ,[SCCO.PSYC] Cognitive science/Psychology ,virtual reality ,sonification - Abstract
In this study, we investigated the ability of blindfolded adults to discriminate between concave and convex auditory virtual surfaces. We used a Leap Motion device to measure the movements of the hand and fingers. Participants were asked to explore the space above the device with the palm of one hand and an auditory feed- back was produced only when the palm was moving into the boundaries of the surface. In order to demonstrate that curvature direction was correctly perceived by our participants, we estimated their discrimination thresholds with a psychophysical staircase procedure. Two groups of participants were fed with two different sonification of the surface. Results showed that most of the participants were able to learn the task. The best results were obtained with an auditory feedback related to the component of the hand velocity tangential to the virtual surface. This work proposes a contribution to the introduction in virtual reality of auditory virtual objects.
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- 2015
30. How does public participation affect perceptions of public–private partnerships? A citizens’ view on push, pull, and network approaches in PPPs
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Boyer, Eric J., primary
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- 2018
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31. Do Executives Approach Leadership Differently When They Are Involved in Collaborative Partnerships? A Perspective from International Nongovernmental Organizations (INGOs)
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Boyer, Eric J., primary, Kolpakov, Aleksey, additional, and Schmitz, Hans Peter, additional
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- 2018
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32. Analysing managerial perceptions of when and how to structure public involvement in public-private partnerships
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Boyer, Eric J., primary, Rogers, Juan D., additional, and Van Slyke, David M., additional
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- 2018
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33. Citizen Attitudes Towards Public–Private Partnerships
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Boyer, Eric J., primary and Van Slyke, David M., additional
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- 2018
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34. Pectoralis Nerve Block compared to Thoracic Paravertebral Nerve Block in the Mastectomy patient: Evidence-based practice recommendations
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Boyer, Eric M.
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- Health, Health Care, Health Sciences, Nursing, Mastectomy, Radical, Modified Radical, PECS Block, TPVB, Pain
- Abstract
Patients undergoing a mastectomy are at increased risk of becoming opioid dependent. Most patients undergoing a mastectomy are diagnosed with breast cancer, and the use of opioids is known to aid in cancer metastasizing due to the suppression of the body's natural killer cells. In addition, regional anesthesia, also known as a nerve block, has long provided a reduction in sensation by blocking the nerve pathway, thus numbing the feeling of pain in the operative area. The Pectoralis nerve block (PECS) and the Thoracic Paravertebral block (TPVB) are used in patients undergoing a mastectomy to help reduce the severity of pain that the body perceives. These nerve block aid in the reduction of supplemental analgesia postoperatively, allowing a lower number of opioids to be consumed. The project's primary purpose is the development of evidence-based clinical recommendations which can be utilized to reduce the intensity of perceived pain for patients undergoing a mastectomy. The recommendations will be determined by selecting which nerve block provides the most significant reduction in the visual acuity scale (VAS) score. Along with the longest time from when the surgery is completed to when the patient first asks for supplemental analgesia by comparing multiple randomized control trial articles comparing the two nerve blocks. The project includes a plan for implementing these evidence-based practice recommendations through education and training, monitoring outcomes, and providing changes to the recommendations if the results are not desirable.
- Published
- 2024
35. Karl Marx: An Intellectual Biography Hosfeld Rolf
- Author
-
Boyer, Eric
- Published
- 2015
36. Sensori-Motor Learning with Movement Sonification: Perspectives from Recent Interdisciplinary Studies
- Author
-
Bevilacqua, Frédéric, Boyer, Eric O., Françoise, Jules, Houix, Olivier, Susini, Patrick, Roby-Brami, Agnès, and Hanneton, Sylvain
- Subjects
sound design ,learning ,interactive systems ,InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.,HCI) ,sonification ,movement ,sensori-motor ,Neuroscience - Abstract
This article reports on an interdisciplinary research project on movement sonification for sensori-motor learning. First, we describe different research fields which have contributed to movement sonification, from music technology including gesture-controlled sound synthesis, sonic interaction design, to research on sensori-motor learning with auditory-feedback. In particular, we propose to distinguish between sound-oriented tasks and movement-oriented tasks in experiments involving interactive sound feedback. We describe several research questions and recently published results on movement control, learning and perception. In particular, we studied the effect of the auditory feedback on movements considering several cases: from experiments on pointing and visuo-motor tracking to more complex tasks where interactive sound feedback can guide movements, or cases of sensory substitution where the auditory feedback can inform on object shapes. We also developed specific methodologies and technologies for designing the sonic feedback and movement sonification. We conclude with a discussion on key future research challenges in sensori-motor learning with movement sonification. We also point out toward promising applications such as rehabilitation, sport training or product design.
- Published
- 2016
- Full Text
- View/download PDF
37. BSI Simian Remote shines with Island 92: remote app behaves just as if it were in the studio
- Author
-
Boyer, Eric R.
- Subjects
Mass communications - Abstract
SIMPSON BAY, St. Maarten--Here at Caribe Broadcasting/Island 92 we use Simian Remote from Broadcast Software International for all of our remotes. We do a lot of remotes with a very [...]
- Published
- 2016
38. An Examination of State-Level Public–Private Partnership Adoption: Analyzing Economic, Political, and Demand-Related Determinants of PPPs
- Author
-
Boyer, Eric J., primary and Scheller, Daniel S., additional
- Published
- 2017
- Full Text
- View/download PDF
39. An Empirical Examination of Partnership Frequency and Design within International Nongovernmental Organizations (INGOs)
- Author
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Boyer, Eric, primary and Kolpakov, Aleksey, additional
- Published
- 2017
- Full Text
- View/download PDF
40. Continuous auditory feedback for sensorimotor learning
- Author
-
Boyer, Eric, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris VI, Sylvain Hanneton, and Patrick Susini
- Subjects
Sound ,Interactivité ,Apprentissage sensori-moteur ,Musique ,Mouvement ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Retour sonore ,Son ,Sensorimotor system - Abstract
Our sensorimotor system has developed a specific relationship between our actions and their sonic outcomes, which it interprets as auditory feedback. The development of motion sensing and audio technologies allows emphasizing this relationship through interactive sonification of movement. We propose several experimental frameworks (visual, non-visual, tangible, virtual) to assess the contribution of sonification to sensorimotor control and learning in interactive systems. First, we show that the auditory system integrates dynamic auditory cues for online motor control, either from head or hand movements. Auditory representations of space and of the scene can be built from audio features and transformed into motor commands. The framework of a virtual sonic object illustrates that auditory-motor representations can shape exploratory movement features and allow for sensory substitution. Second, we measure that continuous auditory feedback in a tracking task helps significantly the performance. Both error and task sonification can help performance but have different effects on learning. We also observe that sonification of user’s movement can increase the energy of produced motion and prevent feedback dependency. Finally, we present the concept of sound-oriented task, where the target is expressed as acoustic features to match. We show that motor adaptation can be driven by interactive audio cues only. In this work, we highlight important guidelines for sonification design in auditory-motor coupling research, as well as applications through original setups we developed, like perceptual and physical training, and playful gesture-sound interactive scenarios for rehabilitation.; Notre système sensorimoteur a développé une relation particulière entre nos actions et le retour sonore qui en découle. Les systèmes de captation gestuelle et les technologies audio permettent de manipuler ce retour sonore par la sonification interactive du mouvement. Nous explorons dans divers cadres expérimentaux la contribution de la sonification à l'apprentissage moteur dans les systèmes interactifs. Tout d'abord, nous montrons que le système auditif intègre des indices acoustiques issus du mouvement pour le contrôle moteur. Des représentations de l'espace émergent de ces indices et sont transformées en commandes motrices. Le cas d'un objet virtuel sonore nous apprend que ces représentations audiomotrices influencent les stratégies d'exploration et permettent des cas de substitution sensorielle par le son. Ensuite, nous mesurons qu'un retour sonore continu permet d'améliorer significativement la performance à une tâche de poursuite. La sonification de l'erreur et des paramètres de la tâche aident à la performance mais montrent des effets différents sur l'apprentissage. Nous observons également que la sonification du mouvement de l'utilisateur augmente l'énergie contenue dans le geste et prévient la dépendance au retour sonore. Enfin, nous présentons le concept de tâche sonore dans lequel la cible est présentée et s'exprime sous forme de paramètres sonores à reproduire. Les résultats montrent qu'une adaptation motrice peut être provoquée par des indices acoustiques seuls. Ce travail permet de dégager des principes importants du design de l'interaction geste-son, et présente des applications originales comme des scénarios interactifs pour la rééducation.
- Published
- 2015
41. Retour sonore continu pour l'apprentissage sensorimoteur
- Author
-
Boyer, Eric, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris VI, Sylvain Hanneton, and Patrick Susini
- Subjects
Sound ,Interactivité ,Apprentissage sensori-moteur ,Musique ,Mouvement ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Retour sonore ,Son ,Sensorimotor system - Abstract
Our sensorimotor system has developed a specific relationship between our actions and their sonic outcomes, which it interprets as auditory feedback. The development of motion sensing and audio technologies allows emphasizing this relationship through interactive sonification of movement. We propose several experimental frameworks (visual, non-visual, tangible, virtual) to assess the contribution of sonification to sensorimotor control and learning in interactive systems. First, we show that the auditory system integrates dynamic auditory cues for online motor control, either from head or hand movements. Auditory representations of space and of the scene can be built from audio features and transformed into motor commands. The framework of a virtual sonic object illustrates that auditory-motor representations can shape exploratory movement features and allow for sensory substitution. Second, we measure that continuous auditory feedback in a tracking task helps significantly the performance. Both error and task sonification can help performance but have different effects on learning. We also observe that sonification of user’s movement can increase the energy of produced motion and prevent feedback dependency. Finally, we present the concept of sound-oriented task, where the target is expressed as acoustic features to match. We show that motor adaptation can be driven by interactive audio cues only. In this work, we highlight important guidelines for sonification design in auditory-motor coupling research, as well as applications through original setups we developed, like perceptual and physical training, and playful gesture-sound interactive scenarios for rehabilitation.; Notre système sensorimoteur a développé une relation particulière entre nos actions et le retour sonore qui en découle. Les systèmes de captation gestuelle et les technologies audio permettent de manipuler ce retour sonore par la sonification interactive du mouvement. Nous explorons dans divers cadres expérimentaux la contribution de la sonification à l'apprentissage moteur dans les systèmes interactifs. Tout d'abord, nous montrons que le système auditif intègre des indices acoustiques issus du mouvement pour le contrôle moteur. Des représentations de l'espace émergent de ces indices et sont transformées en commandes motrices. Le cas d'un objet virtuel sonore nous apprend que ces représentations audiomotrices influencent les stratégies d'exploration et permettent des cas de substitution sensorielle par le son. Ensuite, nous mesurons qu'un retour sonore continu permet d'améliorer significativement la performance à une tâche de poursuite. La sonification de l'erreur et des paramètres de la tâche aident à la performance mais montrent des effets différents sur l'apprentissage. Nous observons également que la sonification du mouvement de l'utilisateur augmente l'énergie contenue dans le geste et prévient la dépendance au retour sonore. Enfin, nous présentons le concept de tâche sonore dans lequel la cible est présentée et s'exprime sous forme de paramètres sonores à reproduire. Les résultats montrent qu'une adaptation motrice peut être provoquée par des indices acoustiques seuls. Ce travail permet de dégager des principes importants du design de l'interaction geste-son, et présente des applications originales comme des scénarios interactifs pour la rééducation.
- Published
- 2015
42. Touching Sounds : Perception of the curvature of Audio Virtual Surfaces
- Author
-
Boyer, Eric O, Vandervoorde, L, Bevilacqua, F, Hanneton, S, Laboratoire Psychologie de la Perception (LPP - UMR 8242), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Interactions Son Musique Mouvement, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Psychologie de la Perception ( LPP - UMR 8242 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,auditory interaction ,Sensory substitution ,[SCCO.PSYC]Cognitive science/Psychology ,virtual reality ,[ SCCO.PSYC ] Cognitive science/Psychology ,sonification - Abstract
International audience; In this study, we investigated the ability of blindfolded adults to discriminate between concave and convex auditory virtual surfaces. We used a Leap Motion device to measure the movements of the hand and fingers. Participants were asked to explore the space above the device with the palm of one hand and an auditory feed- back was produced only when the palm was moving into the boundaries of the surface. In order to demonstrate that curvature direction was correctly perceived by our participants, we estimated their discrimination thresholds with a psychophysical staircase procedure. Two groups of participants were fed with two different sonification of the surface. Results showed that most of the participants were able to learn the task. The best results were obtained with an auditory feedback related to the component of the hand velocity tangential to the virtual surface. This work proposes a contribution to the introduction in virtual reality of auditory virtual objects.
- Published
- 2015
43. SHOP TIPS.
- Author
-
Desmarais, Chris, Bartz, William, Deaver, Alex, Martin, Dan, Padgham, John, Boyer, Eric, and Morgan, Jim
- Subjects
RETAIL stores ,POWER tools - Abstract
DEPARTMENTS Cover-up clamp rack for added storage space In my small shop, I needed a space-efficient storage solution for all my clamps. - Chris Desmarais, Raleigh, N.C. TOP SHOP TIP Clamp racks are custom-designed for the type of clamps to be stored For sending this issue's Top Shop Tip, Chris receives a Senco compressor and nailers worth $340. After assembling the frame and installing the glass, photo, and backer, fit wood strips into the grooves at each corner of the frame without glue. [Extracted from the article]
- Published
- 2020
44. How does public participation affect perceptions of public–private partnerships? A citizens' view on push, pull, and network approaches in PPPs.
- Author
-
Boyer, Eric J.
- Subjects
PUBLIC-private sector cooperation ,PARTICIPATION ,SENSORY perception ,POLITICAL participation ,PUBLIC opinion - Abstract
In this study, we analysed US-based public opinion data to determine the influence of particular modes of participation on citizen perceptions of public–private partnerships (PPP). Our summary finding is that information dissemination can improve community support of PPPs, but interactive engagement is more important, and likely required, for assuring citizens that projects reflect their interests – an issue vital to the long-term sustainability of PPPs. Counter to expectations, respondents indicated a preference for meetings with private partner representatives over those with their public sector counterparts; implying the value of citizen-direct relationships in holding third-party providers to account. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
45. Citizen Attitudes Towards Public–Private Partnerships.
- Author
-
Boyer, Eric J. and Van Slyke, David M.
- Subjects
CITIZEN attitudes ,PUBLIC-private sector cooperation ,PUBLIC opinion ,ACQUISITION of data ,MUNICIPAL services - Abstract
This study examines the factors that influence public attitudes toward public–private partnerships (PPPs) through an analysis of public opinion data collected in 2014. Although previous literature has examined public attitudes toward government contracting and asset privatization, there is little understanding of how the public feels about more collaborative forms of public–private interaction. Counter to previous studies that suggest that support for free enterprise and a disdain for government increases support for private involvement in public services, we find that attitudes toward PPPs are nuanced: Respondents favor them not only when they have positive feelings toward the business sector but also when they also report trust in government. PPPs are thus perceived not as a replacement to public administration, but as a delivery model that demands competence and trust of both public and private partners. The results also explain a previously unstudied relationship between respondent familiarity with PPPs and their attitudes toward them. Counter to expectations, we find that the more familiarity that respondents have with PPPs, the more likely they are to view them favorably. We also identify factors that predict public opinions of PPPs which can inform public outreach and public involvement programs involved with PPPs. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
46. Do Executives Approach Leadership Differently When They Are Involved in Collaborative Partnerships? A Perspective from International Nongovernmental Organizations (INGOs).
- Author
-
Boyer, Eric J., Kolpakov, Aleksey, and Schmitz, Hans Peter
- Subjects
LEADERSHIP ,NONGOVERNMENTAL organizations ,ATTITUDES of leaders ,EXECUTIVES ,MANAGEMENT of nongovernmental organizations - Abstract
Leaders of international nongovernmental organizations (INGOs) navigate daily between the internal politics of their own organization and the external environment. Frequently, these leaders have to make decisions with regard to starting or managing a partnership or collaboration. Although there is extensive literature on collaboration, rarely have the leaders' own perceptions been the focus of analysis. This article draws on transcripts from 137 in-depth, in-person interviews with senior executives of U.S.-based INGOs. The research questions are: What leadership skills and behaviors are perceived to be important among executives of INGOs? and Do leaders view these skills and behaviors differently based on whether or not they are involved in collaborative partnerships? The results show that consensus-driven and visionary leadership are dominant across all leaders, no matter their level of involvement in collaborative partnerships. However, we find differences with regard to other leadership areas. Leaders involved in partnerships are more likely to emphasize motivational leadership and relationship management. Leaders who do not work in partnerships place more emphasis on task-oriented aspects of leadership: decisiveness, cost-effectiveness, and marketing & outreach. These results provide new insights into the possible causes of differences in leadership styles and have implications for both nonprofit and public management. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
47. The Mont-Blanc prototype: an alternative approach for high-performance computing systems
- Author
-
Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rajovic, Nikola, Ramírez Bellido, Alejandro, Rico, Alejandro, Mantovani, Filippo, Ruiz, Daniel, Villarubi, Oriol, Gómez, Constantino, Backes, Luna, Nieto, Diego, Servat, Harald, Martorell Bofill, Xavier, Labarta Mancho, Jesús José, Ayguadé Parra, Eduard, Valero Cortés, Mateo, Adeniyi-Jones, Chris, Derradji, Said, Gloaguen, Hervé, Lanucara, Piero, Sanna, Nico, Mehaut, Jean-François, Pouget, Kevin, Videau, Brice, Boyer, Eric, Allalen, Momme, Auweter, Axel, Brayford, David, Tafani, Daniele, Brömmel, Dirk, Halver, René, Meinke, Jan H., Beivide Palacio, Ramon, Benito, Mariano, Vallejo, Enrique, Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rajovic, Nikola, Ramírez Bellido, Alejandro, Rico, Alejandro, Mantovani, Filippo, Ruiz, Daniel, Villarubi, Oriol, Gómez, Constantino, Backes, Luna, Nieto, Diego, Servat, Harald, Martorell Bofill, Xavier, Labarta Mancho, Jesús José, Ayguadé Parra, Eduard, Valero Cortés, Mateo, Adeniyi-Jones, Chris, Derradji, Said, Gloaguen, Hervé, Lanucara, Piero, Sanna, Nico, Mehaut, Jean-François, Pouget, Kevin, Videau, Brice, Boyer, Eric, Allalen, Momme, Auweter, Axel, Brayford, David, Tafani, Daniele, Brömmel, Dirk, Halver, René, Meinke, Jan H., Beivide Palacio, Ramon, Benito, Mariano, and Vallejo, Enrique
- Abstract
High-performance computing (HPC) is recognized as one of the pillars for further advance of science, industry, medicine, and education. Current HPC systems are being developed to overcome emerging challenges in order to reach Exascale level of performance,which is expected by the year 2020. The much larger embedded and mobile market allows for rapid development of IP blocks, and provides more flexibility in designing an application-specific SoC, in turn giving possibility in balancing performance, energy-efficiency and cost. In the Mont-Blanc project, we advocate for HPC systems be built from such commodity IP blocks, currently used in embedded and mobile SoCs. As a first demonstrator of such approach, we present the Mont-Blanc prototype; the first HPC system built with commodity SoCs, memories, and NICs from the embedded and mobile domain, and off-the-shelf HPC networking, storage, cooling and integration solutions. We present the system’s architecture, and evaluation including both performance and energy efficiency. Further, we compare the system’s abilities against a production level supercomputer. At the end, we discuss parallel scalability, and estimate the maximum scalability point of this approach across a set of HPC applications., Postprint (published version)
- Published
- 2016
48. The Mont-Blanc prototype: an alternative approach for HPC systems
- Author
-
Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rajovic, Nikola, Rico, Alejandro, Mantovani, Filippo, Ruiz, Daniel, Vlarrubi, Josep O., Gomez, Constantino, Backes, Luna, Nieto, Diego, Servat, Harald, Martorell Bofill, Xavier, Labarta Mancho, Jesús José, Ayguadé Parra, Eduard, Adeniyi-Jones, Chris, Derradji, Said, Gloaguen, Hervé, Lanucara, Piero, Sanna, Nico, Mehaut, Jean-François, Pouget, Kevin, Videau, Brice, Boyer, Eric, Allalen, Momme, Auweter, Axel, Brayford, David, Tafani, Daniele, Weinberg, Volker, Brömmel, Dirk, Halver, René, Meinke, Jan H., Beivide Palacio, Ramon, Benito, Mariano, Vallejo, Enrique, Valero Cortés, Mateo, Ramirez, Alex, Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rajovic, Nikola, Rico, Alejandro, Mantovani, Filippo, Ruiz, Daniel, Vlarrubi, Josep O., Gomez, Constantino, Backes, Luna, Nieto, Diego, Servat, Harald, Martorell Bofill, Xavier, Labarta Mancho, Jesús José, Ayguadé Parra, Eduard, Adeniyi-Jones, Chris, Derradji, Said, Gloaguen, Hervé, Lanucara, Piero, Sanna, Nico, Mehaut, Jean-François, Pouget, Kevin, Videau, Brice, Boyer, Eric, Allalen, Momme, Auweter, Axel, Brayford, David, Tafani, Daniele, Weinberg, Volker, Brömmel, Dirk, Halver, René, Meinke, Jan H., Beivide Palacio, Ramon, Benito, Mariano, Vallejo, Enrique, Valero Cortés, Mateo, and Ramirez, Alex
- Abstract
High-performance computing (HPC) is recognized as one of the pillars for further progress in science, industry, medicine, and education. Current HPC systems are being developed to overcome emerging architectural challenges in order to reach Exascale level of performance, projected for the year 2020. The much larger embedded and mobile market allows for rapid development of intellectual property (IP) blocks and provides more flexibility in designing an application specific system-on-chip (SoC), in turn providing the possibility in balancing performance, energy-efficiency, and cost. In the Mont-Blanc project, we advocate for HPC systems being built from such commodity IP blocks, currently used in embedded and mobile SoCs. As a first demonstrator of such an approach, we present the Mont-Blanc prototype; the first HPC system built with commodity SoCs, memories, and network interface cards (NICs) from the embedded and mobile domain, and off-the-shelf HPC networking, storage, cooling, and integration solutions. We present the system’s architecture and evaluate both performance and energy efficiency. Further, we compare the system’s abilities against a production level supercomputer. At the end, we discuss parallel scalability and estimate the maximum scalability point of this approach across a set of applications., Peer Reviewed, Postprint (published version)
- Published
- 2016
49. Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation
- Author
-
Simeonov, Dimitre R., primary, Gowen, Benjamin G., additional, Boontanrart, Mandy, additional, Roth, Theodore, additional, Lee, Youjin, additional, Chan, Alice, additional, Nguyen, Michelle L., additional, Gate, Rachel E., additional, Subramaniam, Meena, additional, Woo, Jonathan M., additional, Mitros, Therese, additional, Ray, Graham J., additional, Bray, Nicolas L., additional, Curie, Gemma L., additional, Naddaf, Nicki, additional, Boyer, Eric, additional, Van Gool, Frederic, additional, Schumann, Kathrin, additional, Daly, Mark J., additional, Fahr, Kyle K., additional, Ye, Chun, additional, Bluestone, Jeffrey A., additional, Anderson, Mark S., additional, Corn, Jacob E., additional, and Marson, Alexander, additional
- Published
- 2016
- Full Text
- View/download PDF
50. The Mont-Blanc Prototype: An Alternative Approach for HPC Systems
- Author
-
Rajovic, Nikola, primary, Rico, Alejandro, additional, Mantovani, Filippo, additional, Ruiz, Daniel, additional, Vilarrubi, Josep Oriol, additional, Gomez, Constantino, additional, Backes, Luna, additional, Nieto, Diego, additional, Servat, Harald, additional, Martorell, Xavier, additional, Labarta, Jesus, additional, Ayguade, Eduard, additional, Adeniyi-Jones, Chris, additional, Derradji, Said, additional, Gloaguen, Herve, additional, Lanucara, Piero, additional, Sanna, Nico, additional, Mehaut, Jean-Francois, additional, Pouget, Kevin, additional, Videau, Brice, additional, Boyer, Eric, additional, Allalen, Momme, additional, Auweter, Axel, additional, Brayford, David, additional, Tafani, Daniele, additional, Weinberg, Volker, additional, Brommel, Dirk, additional, Halver, Rene, additional, Meinke, Jan H., additional, Beivide, Ramon, additional, Benito, Mariano, additional, Vallejo, Enrique, additional, Valero, Mateo, additional, and Ramirez, Alex, additional
- Published
- 2016
- Full Text
- View/download PDF
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