14 results on '"Boakye-Appiah, Justice"'
Search Results
2. Bivalent Omicron BA.4/BA.5 BNT162b2 Vaccine in 6-Month- to <12-Year-Olds.
- Author
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Sher, Lawrence D, Boakye-Appiah, Justice K, Hill, Sungeen, Wasserman, Emily, Xu, Xia, Maldonado, Yvonne, Walter, Emmanuel B, Muñoz, Flor M, Paulsen, Grant C, Englund, Janet A, Talaat, Kawsar R, Barnett, Elizabeth D, Kamidani, Satoshi, Senders, Shelly, Simões, Eric A F, Belanger, Kelly, Parikh, Vrunda, Ma, Hua, Wang, Xingbin, and Lu, Claire
- Subjects
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IMMUNIZATION , *PATIENT safety , *RESEARCH funding , *COVID-19 vaccines , *DESCRIPTIVE statistics , *VACCINE immunogenicity , *DRUG efficacy , *CHILDREN - Abstract
Background With the future epidemiology and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uncertain, the use of safe and effective coronavirus disease 2019 (COVID-19) vaccines in pediatric populations remains important. Methods We report data from two open-label substudies of an ongoing phase 1/2/3 master study (NCT05543616) investigating the safety and immunogenicity of a variant-adapted bivalent COVID-19 vaccine encoding ancestral and Omicron BA.4/BA.5 spike proteins (bivalent BNT162b2). The open-label groups presented here evaluate dose 4 with bivalent BNT162b2 in 6-month- to <12-year-olds who previously received three original (monovalent) BNT162b2 doses. In 6-month- to <5-year-olds, primary immunogenicity objectives were to demonstrate superiority (neutralizing titer) and noninferiority (seroresponse rate) to Omicron BA.4/BA.5 and noninferiority (neutralizing titer and seroresponse rate) to SARS-CoV-2 ancestral strains in participants who received bivalent BNT162b2 dose 4 compared with a matched group who received three doses of original BNT162b2 in the pivotal pediatric study (NCT04816643). In 5- to <12-year-olds, primary immunogenicity comparisons were descriptive. Reactogenicity and safety following vaccination were evaluated. Results In 6-month- to <5-year-olds, dose 4 with bivalent BNT162b2 met predefined immunogenicity superiority and noninferiority criteria against Omicron BA.4/BA.5 and ancestral strains when compared with dose 3 of original BNT162b2. In 5- to <12-year-olds, bivalent BNT162b2 induced robust Omicron BA.4/BA.5 and ancestral strain neutralizing titers comparable with dose 3 of original BNT162b2. The safety profile for dose 4 of bivalent BNT162b2 given as dose 4 was consistent with that of original BNT162b2 in 6-month- to <12-year-olds. Reactogenicity events were generally mild to moderate. No adverse events led to discontinuation. Conclusions These safety and immunogenicity data support a favorable benefit-risk profile for a variant-adapted BNT162b2 in children <12 years old. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Physical distancing and risk of COVID-19 in small-scale fisheries: a remote sensing assessment in coastal Ghana
- Author
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Okyere, Isaac, Chuku, Ernest O., Ekumah, Bernard, Angnuureng, Donatus B., Boakye-Appiah, Justice K., Mills, David J., Babanawo, Raymond, Asare, Noble K., Aheto, Denis W., and Crawford, Brian
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- 2020
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4. Physical distancing and risk of COVID-19 in small-scale fisheries: A remote sensing assessment in coastal Ghana
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Okyere, Isaac, primary, Chuku, Ernest Obeng, additional, Ekumah, Bernard, additional, Angnuureng, Donatus Bapentire, additional, Boakye-Appiah, Justice K., additional, Mills, David Jonathan, additional, Babanawo, Raymond, additional, Aheto, Denis Worlanyo, additional, and Crawford, Brian, additional
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- 2020
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5. Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load
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Frimpong, Michael, primary, Agbavor, Bernadette, additional, Duah, Mabel Sarpong, additional, Loglo, Aloysius, additional, Sarpong, Francisca N., additional, Boakye-Appiah, Justice, additional, Abass, Kabiru M., additional, Dongyele, Mathias, additional, Amofa, George, additional, Tuah, Wilson, additional, Frempong, Margaret, additional, Amoako, Yaw A., additional, Wansbrough-Jones, Mark, additional, and Phillips, Richard O., additional
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- 2019
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- View/download PDF
6. Adolescent health in rural Ghana: A cross-sectional study on the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors
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Alicke, Marie, Boakye-Appiah, Justice K., Henze, Andrea, van der Giet, Markus, Schweigert, Florian J., Mockenhaupt, Frank P., Bedu-Addo, George, Schulze, Matthias B., and Danquah, Ina
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Hypertension ,Vitamin A ,Infectious diseases ,Malaria ,Adolescents ,Iron deficiency ,Malnutrition ,Micronutrient deficiencies - Abstract
In sub-Saharan Africa, infectious diseases and malnutrition constitute the main health problems in children, while adolescents and adults are increasingly facing cardio-metabolic conditions. Among adolescents as the largest population group in this region, we investigated the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors (CRFs), and evaluated demographic, socio-economic and medical risk factors for these entities. In a cross-sectional study among 188 adolescents in rural Ghana, malarial infection, common infectious diseases and Body Mass Index were assessed. We measured ferritin, C-reactive protein, retinol, fasting glucose and blood pressure. Socio-demographic data were documented. We analyzed the proportions (95% confidence interval, CI) and the co-occurrence of infectious diseases (malaria, other common diseases), malnutrition (underweight, stunting, iron deficiency, vitamin A deficiency [VAD]), and CRFs (overweight, obesity, impaired fasting glucose, hypertension). In logistic regression, odds ratios (OR) and 95% CIs were calculated for the associations with socio-demographic factors. In this Ghanaian population (age range, 14.4–15.5 years; males, 50%), the proportions were for infectious diseases 45% (95% CI: 38–52%), for malnutrition 50% (43–57%) and for CRFs 16% (11–21%). Infectious diseases and malnutrition frequently co-existed (28%; 21–34%). Specifically, VAD increased the odds of non-malarial infectious diseases 3-fold (95% CI: 1.03, 10.19). Overlap of CRFs with infectious diseases (6%; 2–9%) or with malnutrition (7%; 3–11%) was also present. Male gender and low socio-economic status increased the odds of infectious diseases and malnutrition, respectively. Malarial infection, chronic malnutrition and VAD remain the predominant health problems among these Ghanaian adolescents. Investigating the relationships with evolving CRFs is warranted.
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- 2017
7. eAdolescent health in rural Ghana: A crosssectional study on the co-occurrence of infectious diseases, malnutrition and cardiometabolic risk factors
- Author
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Alicke, Marie, Boakye-Appiah, Justice K., Abdul-Jalil, Inusah, Henze, Andrea, van der Giet, Markus, Schulze, Matthias Bernd, Schweigert, Florian J., Mockenhaupt, Frank P., Bedu-Addo, George, and Danquah, Ina
- Abstract
In sub-Saharan Africa, infectious diseases and malnutrition constitute the main health problems in children, while adolescents and adults are increasingly facing cardio-metabolic conditions. Among adolescents as the largest population group in this region, we investigated the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors (CRFs), and evaluated demographic, socio-economic and medical risk factors for these entities. In a cross-sectional study among 188 adolescents in rural Ghana, malarial infection, common infectious diseases and Body Mass Index were assessed. We measured ferritin, C-reactive protein, retinol, fasting glucose and blood pressure. Socio-demographic data were documented. We analyzed the proportions (95% confidence interval, CI) and the cooccurrence of infectious diseases (malaria, other common diseases), malnutrition (underweight, stunting, iron deficiency, vitamin A deficiency [VAD]), and CRFs (overweight, obesity, impaired fasting glucose, hypertension). In logistic regression, odds ratios (OR) and 95% CIs were calculated for the associations with socio-demographic factors. In this Ghanaian population (age range, 14.4-15.5 years; males, 50%), the proportions were for infectious diseases 45% (95% CI: 38-52%), for malnutrition 50% (43-57%) and for CRFs 16% (11- 21%). Infectious diseases and malnutrition frequently co-existed (28%; 21-34%). Specifically, VAD increased the odds of non-malarial infectious diseases 3-fold (95% CI: 1.03, 10.19). Overlap of CRFs with infectious diseases (6%; 2-9%) or with malnutrition (7%; 3-11%) was also present. Male gender and low socio-economic status increased the odds of infectious diseases and malnutrition, respectively. Malarial infection, chronic malnutrition and VAD remain the predominant health problems among these Ghanaian adolescents. Investigating the relationships with evolving CRFs is warranted.
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- 2017
8. Adolescent health in rural Ghana
- Author
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Alicke, Marie, Boakye-Appiah, Justice K., Abdul-Jalil, Inusah, Henze, Andrea, van der Giet, Markus, Schulze, Matthias B., Schweigert, Florian J., Mockenhaupt, Frank P., Bedu-Addo, George, and Danquah, Ina
- Subjects
Blood Glucose ,Male ,Rural Population ,Adolescent ,Adolescent Health ,lcsh:Medicine ,Organic chemistry ,Blood Pressure ,Comorbidity ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit ,Adolescents ,Vascular Medicine ,Communicable Diseases ,Ghana ,Body Mass Index ,Chemical compounds ,Sex Factors ,Risk Factors ,Organic compounds ,Medicine and Health Sciences ,Parasitic Diseases ,Prevalence ,Humans ,lcsh:Science ,Vitamin A ,Nutrition ,lcsh:R ,Malnutrition ,Nutritional Deficiencies ,Biology and Life Sciences ,Vitamins ,Overweight ,Tropical Diseases ,Malaria ,Physical sciences ,Chemistry ,Infectious Diseases ,Cross-Sectional Studies ,Socioeconomic Factors ,Age Groups ,Micronutrient Deficiencies ,People and Places ,Hypertension ,Iron Deficiency ,lcsh:Q ,Population Groupings ,Female ,Research Article - Abstract
In sub-Saharan Africa, infectious diseases and malnutrition constitute the main health problems in children, while adolescents and adults are increasingly facing cardio-metabolic conditions. Among adolescents as the largest population group in this region, we investigated the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors (CRFs), and evaluated demographic, socio-economic and medical risk factors for these entities. In a cross-sectional study among 188 adolescents in rural Ghana, malarial infection, common infectious diseases and Body Mass Index were assessed. We measured ferritin, C-reactive protein, retinol, fasting glucose and blood pressure. Socio-demographic data were documented. We analyzed the proportions (95% confidence interval, CI) and the co-occurrence of infectious diseases (malaria, other common diseases), malnutrition (underweight, stunting, iron deficiency, vitamin A deficiency [VAD]), and CRFs (overweight, obesity, impaired fasting glucose, hypertension). In logistic regression, odds ratios (OR) and 95% CIs were calculated for the associations with socio- demographic factors. In this Ghanaian population (age range, 14.4–15.5 years; males, 50%), the proportions were for infectious diseases 45% (95% CI: 38–52%), for malnutrition 50% (43–57%) and for CRFs 16% (11–21%). Infectious diseases and malnutrition frequently co-existed (28%; 21–34%). Specifically, VAD increased the odds of non-malarial infectious diseases 3-fold (95% CI: 1.03, 10.19). Overlap of CRFs with infectious diseases (6%; 2–9%) or with malnutrition (7%; 3–11%) was also present. Male gender and low socio-economic status increased the odds of infectious diseases and malnutrition, respectively. Malarial infection, chronic malnutrition and VAD remain the predominant health problems among these Ghanaian adolescents. Investigating the relationships with evolving CRFs is warranted.
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- 2017
9. High prevalence of multidrug-resistant tuberculosis among patients with rifampicin resistance using GeneXpert Mycobacterium tuberculosis/rifampicin in Ghana
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Boakye-Appiah, Justice K., Steinmetz, Alexis R., Pupulampu, Peter, Ofori-Yirenkyi, Stephen, Tetteh, Ishmael, Frimpong, Michael, Oppong, Patrick, Opare-Sem, Ohene, Norman, Betty R., Stienstra, Ymkje, van der Werf, Tjip S., Wansbrough-Jones, Mark, Bonsu, Frank, Obeng-Baah, Joseph, and Phillips, Richard O.
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- 2016
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10. IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients withMycobacterium ulceransinfection
- Author
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Loglo, Aloysius D., primary, Frimpong, Michael, additional, Sarpong Duah, Mabel, additional, Sarfo, Fred, additional, Sarpong, Francisca N., additional, Agbavor, Bernadette, additional, Boakye-Appiah, Justice K., additional, Abass, Kabiru M., additional, Dongyele, Mathias, additional, Frempong, Margaret, additional, Pidot, Sacha, additional, Wansbrough-Jones, Mark, additional, Stinear, Timothy P., additional, Roupie, Virginie, additional, Huygen, Kris, additional, and Phillips, Richard O., additional
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- 2018
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11. In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study
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Bedu-Addo, George, primary, Alicke, Marie, additional, Boakye-Appiah, Justice K., additional, Abdul-Jalil, Inusah, additional, van der Giet, Markus, additional, Schulze, Matthias B., additional, Mockenhaupt, Frank P., additional, and Danquah, Ina, additional
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- 2017
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12. Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial
- Author
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Phillips, Richard O, Robert, Jérôme, Abass, Kabiru Mohamed, Thompson, William, Sarfo, Fred Stephen, Wilson, Tuah, Sarpong, Godfred, Gateau, Thierry, Chauty, Annick, Omollo, Raymond, Ochieng Otieno, Michael, Egondi, Thaddaeus W, Ampadu, Edwin O, Agossadou, Didier, Marion, Estelle, Ganlonon, Line, Wansbrough-Jones, Mark, Grosset, Jacques, Macdonald, John M, Treadwell, Terry, Saunderson, Paul, Paintsil, Albert, Lehman, Linda, Frimpong, Michael, Sarpong, Nanaa Francisca, Saizonou, Raoul, Tiendrebeogo, Alexandre, Ohene, Sally-Ann, Stienstra, Ymkje, Asiedu, Kingsley B, van der Werf, Tjip S, Osei Mireku, Samuel, Abotsi, Justice, Adu Poku, Joseph Ken, Asamoah-Frimpong, Richard, Osei-Wusu, Bright, Sarpong, Edward, Konadu, Beatrice, Opoku, Ernest, Forson, Mark, Ndogyele, Mathias, Ofori, Elizabeth, Aboagye, Felicity, Berko, Thomas, Amofa, George, Nsiah, Anastasia, Mensah-Bonsu, Joyce, Ofori Nyarko, Joseph, Amoako, Yaw Ampem, Koranteng Tannor, Elliot, Boakye-Appiah, Justice, Dzibordzi Loglo, Aloysius, Sarpong-Duah, Mabel, Agbavor, Bernadette, Ardent, Marie Françoise, Yamadjako, Arnaud, Adanmado Gersande, Naomi, Adeye, Ambroise, Kindjinou, Martial, Akpolan, Kiki, Maxime, Sodjinou, Espoir, Guegnard, Clémence, Klis, Sandor-Adrian, Velding, Kristien, Omansen, Till, Ofori-Adjei, David, Eyangoh, Sarah, Knell, Alan, and Faber, William
- Abstract
Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulceransinfection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia. Standard antimicrobial treatment with oral rifampicin 10 mg/kg plus intramuscular streptomycin 15 mg/kg once daily for 8 weeks (RS8) is highly effective, but streptomycin injections are painful and potentially harmful. We aimed to compare the efficacy and tolerability of fully oral rifampicin 10 mg/kg plus clarithromycin 15 mg/kg extended release once daily for 8 weeks (RC8) with that of RS8 for treatment of early Buruli ulcer lesions.
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- 2020
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13. IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.
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Loglo, Aloysius D., Frimpong, Michael, Duah, Mabel Sarpong, Sarfo, Fred, Sarpong, Francisca N., Agbavor, Bernadette, Boakye-Appiah, Justice K., Abass, Kabiru M., Dongyele, Mathias, Frempong, Margaret, Pidot, Sacha, Wansbrough-Jones, Mark, Stinear, Timothy P., Roupie, Virginie, Huygen, Kris, and Phillips, Richard O.
- Subjects
MYCOBACTERIAL diseases ,ACYL carrier protein ,POLYKETIDE synthases ,BURULI ulcer ,SOFT tissue infections ,ENZYME-linked immunosorbent assay - Abstract
Background: Buruli ulcer is a disease of the skin and soft tissues caused by infection with a slow growing pathogen, Mycobacterium ulcerans. A vaccine for this disease is not available but M. ulcerans possesses a giant plasmid pMUM001 that harbours the polyketide synthase (PKS) genes encoding a multi-enzyme complex needed for the production of its unique lipid toxin called mycolactone, which is central to the pathogenesis of Buruli ulcer. We have studied the immunogenicity of enzymatic domains in humans with M. ulcerans disease, their contacts, as well as non-endemic areas controls. Methods: Between March 2013 and August 2015, heparinized whole blood was obtained from patients confirmed with Buruli ulcer. The blood samples were diluted 1 in 10 in Roswell Park Memorial Institute (RPMI) medium and incubated for 5 days with recombinant mycolactone PKS domains and mycolyltransferase antigen 85A (Ag85A). Blood samples were obtained before and at completion of antibiotic treatment for 8 weeks and again 8 weeks after completion of treatment. Supernatants were assayed for interferon-γ (IFN-γ) and interleukin-5 (IL-5) by enzyme-linked immunosorbent assay. Responses were compared with those of contacts and non-endemic controls. Results: More than 80% of patients and contacts from endemic areas produced IFN-γ in response to all the antigens except acyl carrier protein type 3 (ACP3) to which only 47% of active Buruli ulcer cases and 71% of contacts responded. The highest proportion of responders in cases and contacts was to load module ketosynthase domain (Ksalt) (100%) and enoylreductase (100%). Lower IL-5 responses were induced in a smaller proportion of patients ranging from 54% after ketoreductase type B stimulation to only 21% with ketosynthase type C (KS C). Among endemic area contacts, the, highest proportion was 73% responding to KS C and the lowest was 40% responding to acyltransferase with acetate specificity type 2. Contacts of Buruli ulcer patients produced significantly higher IFN-γ and IL-5 responses compared with those of patients to PKS domain antigens and to mycolyltransferase Ag85A of M. ulcerans. There was low or no response to all the antigens in non-endemic areas controls. IFN-γ and IL-5 responses of patients improved after treatment when compared to baseline results. Discussion: The major response to PKS antigen stimulation was IFN-γ and the strongest responses were observed in healthy contacts of patients living in areas endemic for Buruli ulcer. Patients elicited lower responses than healthy contacts, possibly due to the immunosuppressive effect of mycolactone, but the responses were enhanced after antibiotic treatment. A vaccine made up of the most immunogenic PKS domains combined with the mycolyltransferase Ag85A warrants further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
14. Adolescent health in rural Ghana: A cross-sectional study on the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors.
- Author
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Alicke M, Boakye-Appiah JK, Abdul-Jalil I, Henze A, van der Giet M, Schulze MB, Schweigert FJ, Mockenhaupt FP, Bedu-Addo G, and Danquah I
- Subjects
- Adolescent, Adolescent Health, Blood Glucose, Blood Pressure physiology, Body Mass Index, Comorbidity, Cross-Sectional Studies, Female, Ghana epidemiology, Humans, Male, Prevalence, Risk Factors, Rural Population, Sex Factors, Socioeconomic Factors, Communicable Diseases epidemiology, Hypertension epidemiology, Malnutrition epidemiology, Overweight epidemiology
- Abstract
In sub-Saharan Africa, infectious diseases and malnutrition constitute the main health problems in children, while adolescents and adults are increasingly facing cardio-metabolic conditions. Among adolescents as the largest population group in this region, we investigated the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors (CRFs), and evaluated demographic, socio-economic and medical risk factors for these entities. In a cross-sectional study among 188 adolescents in rural Ghana, malarial infection, common infectious diseases and Body Mass Index were assessed. We measured ferritin, C-reactive protein, retinol, fasting glucose and blood pressure. Socio-demographic data were documented. We analyzed the proportions (95% confidence interval, CI) and the co-occurrence of infectious diseases (malaria, other common diseases), malnutrition (underweight, stunting, iron deficiency, vitamin A deficiency [VAD]), and CRFs (overweight, obesity, impaired fasting glucose, hypertension). In logistic regression, odds ratios (OR) and 95% CIs were calculated for the associations with socio-demographic factors. In this Ghanaian population (age range, 14.4-15.5 years; males, 50%), the proportions were for infectious diseases 45% (95% CI: 38-52%), for malnutrition 50% (43-57%) and for CRFs 16% (11-21%). Infectious diseases and malnutrition frequently co-existed (28%; 21-34%). Specifically, VAD increased the odds of non-malarial infectious diseases 3-fold (95% CI: 1.03, 10.19). Overlap of CRFs with infectious diseases (6%; 2-9%) or with malnutrition (7%; 3-11%) was also present. Male gender and low socio-economic status increased the odds of infectious diseases and malnutrition, respectively. Malarial infection, chronic malnutrition and VAD remain the predominant health problems among these Ghanaian adolescents. Investigating the relationships with evolving CRFs is warranted.
- Published
- 2017
- Full Text
- View/download PDF
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