15 results on '"Blich M"'
Search Results
2. Co-expression of fibulin-5 and VEGF165 increases long-term patency of synthetic vascular grafts seeded with autologous endothelial cells
- Author
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Preis, M, Schneiderman, J, Koren, B, Ben-Yosef, Y, Levin-Ashkenazi, D, Shapiro, S, Cohen, T, Blich, M, Israeli-Amit, M, Sarnatzki, Y, Gershtein, D, Shofti, R, Lewis, B S, Shaul, Y, and Flugelman, M Y
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- 2016
- Full Text
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3. P1595Electrocardiographic comparison of ventricular premature complexes in patients with inherited dilated cardiomyopathy and in patients with ventricular premature complex induced cardiomyopathy
- Author
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Blich, M., primary, Darawsha, W., additional, Laish-Farkash, A., additional, Suleiman, M., additional, Gepstein, L., additional, and Boulous, M., additional
- Published
- 2017
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4. Co-expression of fibulin-5 and VEGF165increases long-term patency of synthetic vascular grafts seeded with autologous endothelial cells
- Author
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Preis, M, Schneiderman, J, Koren, B, Ben-Yosef, Y, Levin-Ashkenazi, D, Shapiro, S, Cohen, T, Blich, M, Israeli-Amit, M, Sarnatzki, Y, Gershtein, D, Shofti, R, Lewis, B S, Shaul, Y, and Flugelman, M Y
- Abstract
Small caliber synthetic vascular grafts are commonly used for bypass surgery and dialysis access sites but have high failure rates because of neointima formation and thrombosis. Seeding synthetic grafts with endothelial cells (ECs) provides a biocompatible surface that may prevent graft failure. However, EC detachment following exposure to blood flow still remains a major obstacle in the development of biosynthetic grafts. We tested the hypothesis that induced expression by the seeded EC, of vascular endothelial growth factor165(VEGF165) and of fibulin-5, an extracellular matrix glycoprotein that has a crucial role in elastin fiber organization and increase EC adherence to surfaces, may improve long-term graft patency. Autologous ECs were isolated from venous segments, and were transduced with retroviral vectors expressing fibulin-5 and VEGF165. The modified cells were seeded on expanded polytetrafluoroethylene (ePTFE) grafts and implanted in a large animal model. Three months after transplantation, all grafts seeded with modified EC were patent on a selective angiography, whereas only a third of the control grafts were patent. Similar results were shown at 6 months. Thus, seeding ePTFE vascular grafts with genetically modified EC improved long-term small caliber graft patency. The biosynthetic grafts may provide a novel therapeutic modality for patients with peripheral vascular disease and patients requiring vascular access for hemodialysis.
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- 2016
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5. Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia.
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Blich M, Zohar Y, Cohen-Kaplan V, Minkov I, Asleh R, Horowitz-Cederboim S, Weiss K, Paperna T, Lessick J, Abadi S, Khoury A, Gepstein L, Suleiman M, and Caspi O
- Subjects
- Humans, Connexin 43 genetics, Connexin 43 metabolism, Mutation genetics, Arrhythmias, Cardiac complications, Myocytes, Cardiac metabolism, Desmoglein 2 genetics, Desmoglein 2 metabolism, Arrhythmogenic Right Ventricular Dysplasia genetics, Cardiomyopathies complications, Tachycardia, Ventricular genetics, Tachycardia, Ventricular complications
- Abstract
Introduction: Arrhythmogenic cardiomyopathy (AC) is an inherited cardiomyopathy characterized by fibro-fatty replacement of cardiomyocytes, leading to life-threatening ventricular arrhythmia and heart failure. Pathogenic variants of desmoglein2 gene (DSG2) have been reported as genetic etiologies of AC. In contrast, many reported DSG2 variants are benign or variants of uncertain significance. Correct genetic variant classification is crucial for determining the best medical therapy for the patient and family members., Methods: Pathogenicity of the DSG2 Ser194Leu variant that was identified by whole exome sequencing in a patient, who presented with ventricular tachycardia and was diagnosed with AC, was investigated by electron microscopy and immunohistochemical staining of endomyocardial biopsy sample., Results: Electron microscopy demonstrated a widened gap in the adhering junction and a less well-organized intercalated disk region in the mutated cardiomyocytes compared to the control. Immunohistochemical staining in the proband diagnosed with AC showed reduced expression of desmoglein 2 and connexin 43 and intercalated disc distortion. Reduced expression of DSG2 and Connexin 43 were observed in cellular cytoplasm and gap junctions. Additionally, we detected perinuclear accumulation of DSG2 and Connexin 43 in the proband sample., Conclusion: Ser194Leu is a missense pathogenic mutation of DSG2 gene associated with arrhythmogenic left ventricular cardiomyopathy., (© 2024 Wiley Periodicals LLC.)
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- 2024
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6. The role of early cardiac resynchronization therapy implantation in dilated cardiomyopathy patients with narrow QRS carrying lamin A/C mutation.
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Blich M, Darawsha W, Eyal A, Shehadeh F, Boulous M, Gepstein L, and Suleiman M
- Abstract
Background: Dilated cardiomyopathy (DCM) caused by Lamin A/C gene (LMNA) mutation is complicated with atrioventricular conduction disturbances, malignant ventricular arrhythmias and progressive severe heart failure., Objective: We hypothesized that early cardiac resynchronization therapy (CRT) implantation in LMNA mutation carriers with an established indication for pacemaker or implantable cardioverter defibrillator (ICD), may preserve ejection fraction, and delay disease progression to end stage heart failure., Methods: We compared the primary outcomes: time to heart transplantation, death due to end stage heart failure or ventricular tachycardia (VT) ablation and secondary outcomes: change in left ventricular ejection fraction (EF) and ventricular arrhythmia burden between LMNA DCM patients in the early CRT and non-CRT groups., Results: Of ten LMNA DCM patients (age 51±10 years, QRS 96±14 msec, EF 55±7%) with indication for pacemaker or ICD implantation, five underwent early CRT-D implantation. After 7.2±4 years, three patients (60%) in the non-CRT group reached the primary outcome, compared to no patients in the CRT group (P=0.046). Four patients in non-CRT group (80%) experienced sustained ventricular tachycardia or received appropriate ICD shock compared to 1 patient (20%) in the CRT group (P=0.058). LMNA patients without early CRT had a higher burden of VPC/24 h in 12-lead holter (median 2352 vs 185, P=0.09). Echocardiography showed statistically lower LVEF in the non-CRT group compared to CRT group [(32±15)% vs (61±4)%, 95% CI: 32.97-61.03, P=0.016]., Conclusion: Early CRT implantation in LMNA cardiomyopathy patients, with an indication for pacemaker or ICD, may reduce heart failure deterioration and life-threatening heart failure complications., Competing Interests: None., (AJCD Copyright © 2024.)
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- 2024
7. The role of genetic testing in the prevention, diagnosis, and prognosis of sudden cardiac arrest in children.
- Author
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Blich M, Oron H, Darawsha W, Suleiman M, Gepstein L, Boulos M, Lorber A, and Kchoury A
- Abstract
Background: Determining the pathogenesis of sudden cardiac arrest (SCA) in children is crucial for its management and prognosis. Our aim is to analyze the role of broad genetic testing in the prevention, diagnosis, and prognosis of SCA in Children., Methods: ECG, 12-lead holter, exercise testing, cardiac imaging, familial study, and genetic testing were used to study 29 families, in whom a child experienced SCA., Results: After a thorough clinical and genetic evaluation a positive diagnosis was reached in 24/29 (83%) families. Inherited channelopathies (long QT syndrome and catecholaminergic polymorphic ventricular tachycardia) were the most prevalent 20/29 (69%) diagnosis, followed by cardiomyopathy 3/29 (10%). Broad genetic testing was positive in 17/24 (71%) cases. Using the Mann-Whitney test, we found that genetic testing (effect size = 0.625, p = 0.003), ECG (effect size = 0.61, p = 0.009), and exercise test (effect size = 0.63, p = 0.047) had the highest yield in reaching the final diagnosis. Genetic testing was the only positive test available for five (17%) families. Among 155 family members evaluated through cascade screening, 73 (47%) had a positive clinical evaluation and 64 (41%) carried a pathologic mutation. During 6 ± 4.8 years of follow-up, 58% of the survived children experienced an arrhythmic event. Of nine family members who had an ICD implant for primary prevention, four experienced appropriate ICD shock., Conclusions: The major causes of SCA among children are genetic etiology, and genetic testing has a high yield. Family screening has an additional role in both the diagnosis and preventing of SCA., Competing Interests: Authors declare no conflict of interests for this article., (© 2023 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society.)
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- 2023
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8. Acute Q Fever with Atrioventricular Block, Israel.
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Badarni K, Blich M, Atiya-Nasagi Y, and Ghanem-Zoabi N
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- Fever etiology, Humans, Israel epidemiology, Young Adult, Atrioventricular Block diagnosis, Atrioventricular Block etiology, Atrioventricular Block therapy, Coxiella burnetii, Q Fever diagnosis
- Abstract
Cardiac involvement in acute Q fever is rare. We report 2 cases of an advanced atrioventricular block in young adult patients in Israel who sought care for acute Q fever without evidence of myocarditis. Q fever should be suspected in unexplained conduction abnormalities, especially in febrile young patients residing in disease-endemic areas.
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- 2022
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9. Non-ischemic sudden cardiac arrest: Role of 12 lead Holter, family screening and genetic testing.
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Blich M, Oron H, Darawsha W, Suleiman M, Avraham L, Asaad K, Boulos M, and Gepstein L
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- Adult, Female, Genetic Predisposition to Disease, Humans, Israel, Magnetic Resonance Imaging, Male, Prognosis, Retrospective Studies, Risk Factors, Death, Sudden, Cardiac, Electrocardiography, Ambulatory, Genetic Testing
- Abstract
Objective and Background: To evaluate the diagnostic and prognostic yield of a comprehensive protocol involving clinical and broad genetic testing in consecutive sudden cardiac arrest (SCA) population. Determining the pathogenesis of non-ischemic SCA is crucial for management and SCA prevention in other family members METHODS: Families with unexplained non-ischemic SCA event underwent rigorous clinical and genetic protocol after referral to our inherited arrhythmia clinic, during 2011-2017., Results: One hundred and four index cases, 29 ± 16 years, and 421 family members were studied. After a thorough evaluation, diagnosis was made in 80 (77%) of families. The most prevalent 47/104 (45%) diagnosis was inherited channelopathy. The genetic test was positive, in 37 /69 (54%) of patients. Using the Mann Whitney test, we found that electrocardiography (ECG) (effect size 0.5, p < .001), 12 lead Holter (effect size 0.33, p = .001) and family screening (effect size 0.4, p = .001) had the highest yield in reaching the final diagnosis. Family screening, genetic testing, and cardiac MRI were the exclusive modalities for final diagnosis in 14%, 9%, and 2% of families, respectively. Among 421 family members evaluated through cascade screening, 127 (30%), were diagnosed and medically treated. Nine family members from 25 (40%) patients who underwent implantable cardioverter defibrillator (ICD) implantation have experienced appropriate ICD shock., Conclusions: A rigorous, systematic protocol in a specialized inherited arrhythmia clinic has a high diagnostic and prognostic yield. ECG, 12 lead Holter and family screening significantly increased the diagnostic yield. In nine families, without genetic testing, the diagnosis would have been missed., (© 2021 Wiley Periodicals LLC.)
- Published
- 2021
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10. Specific Therapy Based on the Genotype in a Malignant Form of Long QT3, Carrying the V411M Mutation.
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Blich M, Khoury A, Suleiman M, Lorber A, Gepstein L, and Boulous M
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- Child, DNA Mutational Analysis, Female, Humans, Long QT Syndrome diagnosis, Long QT Syndrome genetics, NAV1.5 Voltage-Gated Sodium Channel metabolism, Voltage-Gated Sodium Channel Blockers therapeutic use, DNA genetics, Electrocardiography, Flecainide therapeutic use, Long QT Syndrome drug therapy, Mutation, NAV1.5 Voltage-Gated Sodium Channel genetics
- Abstract
Congenital long QT syndrome (LQTS) is a cardiac channelopathy that leads to the prolongation of the QT interval. This prolongation can lead to ventricular tachyarrhythmia, syncope, and sudden cardiac death. There are various types of LQTS. Treatment of LQT1 and LQT2 is mainly based on antiadrenergic therapy. LQT3, on the other hand, is a result of a mutation of the SCN5A gene, which encodes the sodium channels. In this type, patients are sensitive to vagal stimuli and episodes tend to occur at rest. Sodium channel blocking compounds, such as ranolazine, mexiletine, and flecainide, have been found to be effective in selective mutations.In this case report, we report the case of a child with congenital LQT3 (V411M) who presented first with sudden cardiac death and three weeks later with an implantable cardioverter defibrillator storm. Knowing the specific mutation and understanding the mechanism at the molecular level through an in vitro study yielded a clinically meaningful result. The patient's arrhythmia burden was totally eliminated following successful treatment with flecainide.
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- 2019
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11. Arrhythmic Events in Brugada Syndrome: A Nationwide Israeli Survey of the Clinical Characteristics, Treatment; and Long-Term Follow-up (ISRABRU-VF).
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Leshem E, Rahkovich M, Mazo A, Suleiman M, Blich M, Laish-Farkash A, Konstantino Y, Fogelman R, Strasberg B, Geist M, Chetboun I, Swissa M, Ilan M, Glick A, Michowitz Y, Rosso R, Glikson M, and Belhassen B
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- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac therapy, Brugada Syndrome therapy, Cohort Studies, Comorbidity, Electrocardiography methods, Female, Follow-Up Studies, Humans, Israel epidemiology, Male, Middle Aged, Quinidine therapeutic use, Young Adult, Arrhythmias, Cardiac epidemiology, Arrhythmias, Cardiac physiopathology, Brugada Syndrome epidemiology, Brugada Syndrome physiopathology, Defibrillators, Implantable
- Abstract
Background: Limited information exists about detailed clinical characteristics and management of the small subset of Brugada syndrome (BrS) patients who had an arrhythmic event (AE)., Objectives: To conduct the first nationwide survey focused on BrS patients with documented AE., Methods: Israeli electrophysiology units participated if they had treated BrS patients who had cardiac arrest (CA) (lethal/aborted; group 1) or experienced appropriate therapy for tachyarrhythmias after prophylactic implantable cardioverter defibrillator (ICD) implantation (group 2)., Results: The cohort comprised 31 patients: 25 in group 1, 6 in group 2. Group 1: 96% male, mean CA age 38 years (range 13-84). Nine patients (36%) presented with arrhythmic storm and three had a lethal outcome; 17 (68%) had spontaneous type 1 Brugada electrocardiography (ECG). An electrophysiology study (EPS) was performed on 11 patients with inducible ventricular fibrillation (VF) in 10, which was prevented by quinidine in 9/10 patients. During follow-up (143 ± 119 months) eight patients experienced appropriate shocks, none while on quinidine. Group 2: all male, age 30-53 years; 4/6 patients had familial history of sudden death age < 50 years. Five patients had spontaneous type 1 Brugada ECG and four were asymptomatic at ICD implantation. EPS was performed in four patients with inducible VF in three. During long-term follow-up, five patients received ≥ 1 appropriate shocks, one had ATP for sustained VT (none taking quinidine). No AE recurred in patients subsequently treated with quinidine., Conclusions: CA from BrS is apparently a rare occurrence on a national scale and no AE occurred in any patient treated with quinidine.
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- 2018
12. Impact of computed tomography image and contact force technology on catheter ablation for atrial fibrillation.
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Marai I, Suleiman M, Blich M, Lessick J, Abadi S, and Boulos M
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Aim: To investigate the impact of using computed tomography (CT) and contact force (CF) technology on recurrence of atrial tachyarrhythmia after atrial fibrillation (AF) ablation., Methods: This non-randomized study included 2 groups of patients. All patients had symptomatic recurrent paroxysmal or persistent AF and were treated with at least 1 anti arrhythmic medication or intolerant to medication. The first group included 33 patients who underwent circumferential pulmonary veins isolation (PVI) for AF during 2012 and 2013 guided by CT image integration (Cartomerge, Biosense Webster, Diamond Bar, CA, United States) of left atrium and pulmonary veins into an electroanatomic mapping (EAM) system (CT group) using standard irrigated radiofrequency catheter (ThermoCool, Carto, Biosense Webster, Diamond Bar, CA, United States) or irrigated catheter with integrated CF sensor (Smart Touch, Carto, Biosense Webster, Diamond Bar, CA, United States). The second group included immediately preceding 32 patients who had circumferential PVI by standard irrigated catheter (ThermoCool) using only EAM (Carto) system (EAM group). Linear lesions were performed according to the discretion of operator., Results: Sex, age, and persistent AF were not different between groups. PVI was achieved in all patients in both groups. Linear ablations including cavo-tricuspid isthmus and or roof line ablation were not different between groups. Free of atrial tachyarrhythmia during follow-up of 24 mo was significantly higher among CT group compared to EAM group (81% vs 55%; respectively; P = 0.027). When 11 patients from CT group who had ablation using Smart Touch catheter were excluded, the difference between CT group and EAM became non significant (73% vs 55%; respectively; P = 0.16). Sub analysis of CT group showed that patients who had ablation using Smart Touch catheter tend to be more free of atrial tachyarrhythmia compared to patients who had ablation using standard irrigated catheter during follow-up (100% vs 73%; respectively; P = 0.07). Major complications (pericardial effusion, cerebrovascular accident/transient ischemic attack, vascular access injury requiring intervention) did not occurred in both groups., Conclusion: These preliminary results suggest that CT image integration and CF technology may reduce the recurrence of atrial tachyarrhythmia after catheter ablation for AF.
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- 2016
- Full Text
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13. Outflow tract ventricular arrhythmia originating from the aortic cusps: our approach for challenging ablation.
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Marai I, Boulos M, Lessick J, Abadi S, Blich M, and Suleiman M
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- Adult, Aortic Valve diagnostic imaging, Body Surface Potential Mapping methods, Case-Control Studies, Cohort Studies, Female, Heart Conduction System diagnostic imaging, Humans, Male, Middle Aged, Multimodal Imaging methods, Pregnancy, Surgery, Computer-Assisted methods, Tachycardia, Ventricular diagnosis, Tomography, X-Ray Computed methods, Treatment Outcome, Ventricular Premature Complexes diagnosis, Aortic Valve surgery, Catheter Ablation methods, Heart Conduction System surgery, Heart Ventricles surgery, Tachycardia, Ventricular surgery, Ventricular Premature Complexes surgery
- Abstract
Background: Ablation of outflow flow ventricular arrhythmia (VA) originating from aortic cusps can be challenging. The aim of this study was to describe our approach for this ablation., Methods: All patients with outflow VA suspected to originate from aortic cusps according to ECG or after failed ablation from right ventricular outflow tract (RVOT) underwent cardiac CT and radiofrequency ablation. CT image of aortic cusps and coronary arteries was integrated into electroanatomic mapping system by point (left main ostium)-based registration. Ablation was performed at the earliest activation site., Results: Ten patients were included in this case cohort. The ablation catheter was easily maneuvered above and below the aortic valve after registration. Two patients who had previous failed ablation of RVOT focus had successful ablation at right coronary cusp (RCC) and at left coronary cusp (LCC). A patient who had previous failed ablations of RVOT and LCC focuses had successful ablation at RCC-LCC junction. A patient who had previous failed ablation at LCC had successful ablation at RCC-LCC junction. Three patients had successful ablation at RCC-LCC junction, and one patient at LCC. One patient had successful ablation at anterior interventricular vein-great cardiac vein junction. One patient had successful ablation at non-coronary cusp. During follow-up (12-30 months), one patient had recurrence of VA controlled by flecainide. The remaining patients were free of VA without medications., Conclusions: Catheter ablation of VA originating from aortic cusps is safe and effective. CT image integration into electroanatomic mapping system can be helpful in this challenging ablation.
- Published
- 2016
- Full Text
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14. Electrocardiographic comparison of ventricular premature complexes during exercise test in patients with CPVT and healthy subjects.
- Author
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Blich M, Marai I, Suleiman M, Lorber A, Gepstein L, Boulous M, and Khoury A
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- Adolescent, Calsequestrin genetics, Exercise Test, Female, Healthy Volunteers, Humans, Male, Sensitivity and Specificity, Tachycardia, Ventricular genetics, Tachycardia, Ventricular physiopathology, Ventricular Premature Complexes genetics, Ventricular Premature Complexes physiopathology, Electrocardiography, Tachycardia, Ventricular diagnosis, Ventricular Premature Complexes diagnosis
- Abstract
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but highly malignant inherited arrhythmic disorder. Although a standardized exercise stress test (ST) is the most reliable way to diagnose CPVT, in 30% only single ventricular premature beats (VPCs) were recorded., Objective: To evaluate whether electrocardiographic characteristics of VPCs during ST distinguish patients with CPVT from healthy subjects., Methods: Electrocardiographic characteristics of VPCs during ST in 16 calsequestrin-2 (CASQ2) mutation carriers CPVT patients were compared with that in 36 healthy subjects., Results: CPVT patients had more VPCs (31 ± 14 vs 3 ± 4, P < 0.0001), longer QRS duration (139 ± 18 ms vs 121 ± 21, P = 0.004), and coupling interval (CI; 476 ± 58 ms vs 355 ± 61 ms, P < 0.0001). The most sensitive characteristics for CPVT were >10 VPCs/test (100% sensitivity, 100% negative predictive value [NPV]), left bundle branch block (LBBB) pattern with inferior axis (88% sensitivity, 94% NPV), and CI longer than 400 ms (88% sensitivity, 94% NPV). Bigeminy or trigeminy or LBBB pattern with inferior axis was most specific for CPVT at 100% (100% positive predictive value PPV, 92% NPV). First VPC during the recovery period and VPC recording more than 1 minute during the recovery period were most specific for healthy subjects (100% specificity, 100% PPV). In multivariate analysis, QRS duration >120 ms (odds ratio 4.2, 95% confidence interval 1-17.6, P = 0.04) and first VPC at ≥10 mets (odds ratio 9.1, 95% confidence interval 2.01-41.1, P = 0.004) each predicted the presence of CPVT., Conclusions: Several electrocardiographic criteria can help distinguish VPCs originating from CPVT compared with healthy subjects., (©2015 Wiley Periodicals, Inc.)
- Published
- 2015
- Full Text
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15. Novel Clinical Manifestation of the Known SCN5A D1790G Mutation.
- Author
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Blich M, Efrati E, Marai I, Suleiman M, Gepstein L, and Boulous M
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- Cardiac Conduction System Disease, Electrocardiography, Ambulatory, Genetic Testing, Humans, Male, Middle Aged, Mutation, Missense, Sodium blood, Brugada Syndrome genetics, Long QT Syndrome genetics, NAV1.5 Voltage-Gated Sodium Channel genetics
- Abstract
The D1790G mutation was found in all 24 patients of an extended long QT family but not in 200 chromosomes carried by healthy individuals. We describe a 37-year-old man presenting with a typical spontaneous type 1 Brugada pattern who in electrophysiological testing had easily inducible ventricular fibrillation. At the age of 47 years he had an atrial ventricular type 2 block documented by an exercise test and a Holter monitor. Genetic analysis revealed a known D1790G mutation in the gene encoding of the sodium channel (SCN5A) that until now has been associated only with the long QT phenotype. Although this mutation has not been associated with a reduction of sodium channel expression, we hypothesize that sodium currents are further diminished due to the 20-mV shift of the steady-state inactivation curve, and this could contribute to the Brugada phenotype. This case is important as it allows a better understanding of the underlying molecular mechanisms of Brugada syndrome. Moreover, this observation raises concern about the safety of class IC drug therapy in long QT type 3 patients and quinidine therapy in Brugada patients, and emphasizes the importance of a thorough clinical and genetic evaluation., (© 2015 S. Karger AG, Basel.)
- Published
- 2015
- Full Text
- View/download PDF
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