Search

Your search keyword '"Blanke, Philipp"' showing total 1,128 results
Start Over Author "Blanke, Philipp" Publication Year Range Last 10 years

Refine your results

more »

more »

more »

more »

more »
1,128 results on '"Blanke, Philipp"'

4. Patient-Prosthesis Mismatch After Surgical Aortic Valve Replacement: Analysis of the PARTNER Trials

Author

Thourani, Vinod H., Abbas, Amr E., Ternacle, Julien, Hahn, Rebecca T., Makkar, Raj, Kodali, Susheel K., George, Isaac, Kapadia, Samir, Svensson, Lars G., Szeto, Wilson Y., Herrmann, Howard C., Ailawadi, Gorav, Leipsic, Jonathon, Blanke, Philipp, Webb, John, Jaber, Wael A., Russo, Mark, Malaisrie, S. Chris, Yadav, Pradeep, Clavel, Marie-Annick, Khalique, Omar K., Weissman, Neil J., Douglas, Pamela, Bax, Jeroen, Dahou, Abdellaziz, Xu, Ke, Bapat, Vinayak, Alu, Maria C., Leon, Martin B., Mack, Michael J., and Pibarot, Philippe

Published
2024
Full Text
View/download PDF

5. Aspirin and Statin Therapy for Nonobstructive Coronary Artery Disease: Five-year Outcomes from the CONFIRM Registry

Author

Indraratna, Praveen, Naoum, Christopher, Ben Zekry, Sagit, Gransar, Heidi, Blanke, Philipp, Sellers, Stephanie, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Maffei, Erica, Marques, Hugo, Gonçalves, Pedro de Araújo, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, Lin, Fay Y, Shaw, Leslee J, Narula, Jagat, Bax, Jeroen J, and Leipsic, Jonathon A

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Cardiovascular, Heart Disease - Coronary Heart Disease, Heart Disease, Clinical Trials and Supportive Activities, Atherosclerosis, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Aspirin, CT Angiography, Coronary Artery Disease, Nonobstructive Coronary Artery Disease, Statin
Abstract

PurposeIn this cohort study, 5-year data from the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry (ie, CONFIRM) were examined to identify associations of baseline aspirin and statin use with mortality, major adverse cardiovascular events (MACE), and myocardial infarction (MI) in individuals without substantial (≥50%) stenosis.Materials and methodsIn this prospective cohort study, all participants in the registry underwent coronary CT angiography and were classified as having no detectable coronary plaque or having nonobstructive coronary artery disease (CAD) (1%-49% stenosis). Participants with obstructive (≥50%) stenosis were excluded from analysis. The study commenced in June 2003 and was completed in March 2016. All unadjusted and risk-adjusted analyses utilized the Cox proportional hazard model with hospital sites modeled using shared frailty.ResultsA total of 6386 participants with no detectable plaque or with nonobstructive CAD were included (mean age, 56.0 years ± 13.3 [SD], 52% men). The mean follow-up period was 5.66 years ± 1.10. Nonobstructive CAD (n = 2815, 44% of all participants included in the study) was associated with a greater risk of all-cause mortality (10.6% [298 of 2815] vs 4.8% [170 of 3571], P < .001) compared to those without CAD (n = 3571, 56%). Baseline aspirin and statin use was documented for 1415 and 1429 participants, respectively, with nonobstructive CAD, and for 1560 and 1565 participants without detectable plaque, respectively. In individuals with nonobstructive CAD, baseline aspirin use was not associated with a reduction in MACE (10.9% [102 of 936] vs 14.7% [52 of 355], P = .06), all-cause mortality (9.6% [95 of 991] vs 10.9% [46 of 424], P = .468), or MI (4.4% [41 of 936] vs 6.2% [22 of 355], P = .18). On multivariate risk-adjusted analysis, baseline statin use was associated with a lower rate of MACE (hazard ratio, 0.59; 95% CI: 0.40, 0.87; P = .007). Neither therapy improved clinical outcomes for participants with no detectable plaque.ConclusionIn participants with nonobstructive CAD, baseline use of statins, but not of aspirin, was associated with improved clinical outcomes. Neither therapy was associated with benefit in participants without plaque.Keywords: Aspirin, Statin, Coronary Artery Disease, CT Angiography, Nonobstructive Coronary Artery DiseaseClinical trial registration no. NCT01443637 Supplemental material is available for this article. © RSNA, 2022See also the commentary by Canan and Navar in this issue.

Published
2022

6. Feasibility and Utility of Anatomical and Physiological Evaluation of Coronary Disease With Cardiac CT in Severe Aortic Stenosis (FUTURE-AS Registry): Rationale and Design

Author

Khoo, John King, Sellers, Stephanie, Fairbairn, Timothy, Polsani, Venkateshwar, Liu, Shizhen, Yong, Gerald, Shetty, Sharad, Corrigan, Frank, Ko, Brian, Vucic, Esad, Fitzgibbons, Timothy P., Kakouros, Nikolaos, Blanke, Philipp, Sathananthan, Janarthanan, Webb, John, Wood, David, Leipsic, Jonathon, and Ihdayhid, Abdul Rahman

Published
2024
Full Text
View/download PDF

10. Novel 4DCT Method to Measure Regional Left Ventricular Endocardial Shortening Before and After Transcatheter Mitral Valve Implantation

Author

Colvert, Gabrielle M, Manohar, Ashish, Contijoch, Francisco J, Yang, James, Glynn, Jeremy, Blanke, Philipp, Leipsic, Jonathon A, and McVeigh, Elliot R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Cardiovascular, Biomedical Imaging, Heart Disease, Mitral regurgitation, myocardial strain, LV function, TMVI, 4DCT, LV remodeling, LV Remodeling, Mitral Regurgitation, Myocardial Strain
Abstract

BackgroundRegional left ventricular (LV) mechanics in mitral regurgitation (MR) patients, and local changes in function after transcatheter mitral valve implantation (TMVI) have yet to be evaluated. Herein, we introduce a method for creating high resolution maps of endocardial function from 4DCT images, leading to detailed characterization of changes in local LV function. These changes are particularly interesting when evaluating the effect of the Tendyne™ TMVI device in the region of the epicardial pad.MethodsRegional endocardial shortening from CT (RSCT) was evaluated in Tendyne (Abbott Medical) TMVI patients with 4DCT exams pre- and post-implantation. Regional function was evaluated in 90 LV segments (5 longitudinal × 18 circumferential). LV volumes and ejection fraction (EF) were also computed. A reproducibility study was performed in a subset of patients to determine the precision of RSCT measurements in this population.ResultsBaseline and local changes in RSCT post TMVI were highly variable and extremely spatially heterogeneous. Both inter- and intra-observer variability were low and demonstrated the high precision of RSCT for evaluating regional LV function.ConclusionRSCT is a reproducible metric which can be evaluated in patients with highly abnormal regional LV function and geometry. After TMVI, significant spatially heterogeneous changes in RSCT were observed in all subjects; therefore, it is unlikely that the functional state of TMVI patients can be fully described by changes in LV volume or EF. Measurement of RSCT provides precise characterization of the spatially heterogeneous effects of MR and TMVI on LV function and remodeling.

Published
2021

11. Valve-in-Valve Transcatheter Mitral Valve Replacement: A Large First-in-Human 13-Year Experience

Author

Akodad, Mariama, Trpkov, Cvet, Cheung, Anson, Ye, Jian, Chatfield, Andrew G., Alosail, Abdulmajeed, Besola, Laura, Yu, Maggie, Leipsic, Jonathon A., Lounes, Youcef, Meier, David, Yang, Cathevine, Nestelberger, Thomas, Tzimas, Georgios, Sathananthan, Janarthanan, Wood, David A., Moss, Rob R., Blanke, Philipp, Sathananthan, Gnalini, and Webb, John G.

Published
2023
Full Text
View/download PDF

13. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Arnold, Suzanne, Bapat, Vinayak, Berry, Natalia, Blanke, Philipp, Burkhoff, Daniel, Coylewright, Megan, Duggal, Neal, Galper, Benjamin, George, Isaac, Guerrero, Mayra, Hamid, Nadira, Jagadeesan, Vikrant, Kodali, Susheel, Krucoff, Mitch, Lang, Roberto, Madhavan, Mahesh, McLaughin, Vallerie, Mehran, Roxana, Philippon, Francois, Sethi, Sanjum S., Simonato, Matheus, Smith, Robert, Sodhi, Nishtha, Spertus, John, Stocker, Thomas J., Stone, Gregg, Hahn, Rebecca T., Lawlor, Matthew K., Davidson, Charles J., Badhwar, Vinay, Sannino, Anna, Spitzer, Ernest, Lurz, Philipp, Lindman, Brian R., Topilsky, Yan, Baron, Suzanne J., Chadderdon, Scott, Khalique, Omar K., Tang, Gilbert H.L., Taramasso, Maurizio, Grayburn, Paul A., Badano, Luigi, Leipsic, Jonathon, Lindenfeld, JoAnn, Windecker, Stephan, Vemulapalli, Sreekanth, Redfors, Bjorn, Alu, Maria C., Cohen, David J., Rodés-Cabau, Josep, Ailawadi, Gorav, Mack, Michael, Ben-Yehuda, Ori, Leon, Martin B., and Hausleiter, Jörg

Published
2023
Full Text
View/download PDF

14. Effects of renin-angiotensin-aldosterone-system inhibitors on coronary atherosclerotic plaques: The PARADIGM registry

Author

Williams, Curtis, Han, Donghee, Takagi, Hidenobu, Fordyce, Christopher B., Sellers, Stephanie, Blanke, Philipp, Lin, Fay Y., Shaw, Leslee J., Lee, Sang-Eun, Andreini, Daniele, Al-Mallah, Mouaz H., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, Marques, Hugo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Maffei, Erica, Pontone, Gianluca, Shin, Sanghoon, Kim, Yong-Jin, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Virmani, Renu, Samady, Habib, Stone, Peter H., Berman, Daniel S., Narula, Jagat, Bax, Jeroen J., Leipsic, Jonathon A., and Chang, Hyuk-Jae

Published
2023
Full Text
View/download PDF

15. Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement

Author

Guerrero, Mayra E., Grayburn, Paul, Smith, Robert L., II, Sorajja, Paul, Wang, Dee Dee, Ahmad, Yousif, Blusztein, David, Cavalcante, João, Tang, Gilbert H.L., Ailawadi, Gorav, Lim, D. Scott, Blanke, Philipp, Eleid, Mackram F., Kaneko, Tsuyoshi, Thourani, Vinod H., Bapat, Vinayak, Mack, Michael J., Leon, Martin B., and George, Isaac

Published
2023
Full Text
View/download PDF

17. Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study

Author

Tang, Gilbert H.L., Spencer, Julianne, Rogers, Toby, Grubb, Kendra J., Gleason, Patrick, Gada, Hemal, Mahoney, Paul, Dauerman, Harold L., Forrest, John K., Reardon, Michael J., Blanke, Philipp, Leipsic, Jonathon A., Abdel-Wahab, Mohamed, Attizzani, Guilherme F., Puri, Rishi, Caskey, Michael, Chung, Christine J., Chen, Ying-Hwa, Dudek, Dariusz, Allen, Keith B., Chhatriwalla, Adnan K., Htun, Wah Wah, Blackman, Daniel J., Tarantini, Giuseppe, Zhingre Sanchez, Jorge, Schwartz, Greta, Popma, Jeffrey J., and Sathananthan, Janarthanan

Published
2023
Full Text
View/download PDF

18. The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease

Author

Jin, Han-Young, Weir-McCall, Jonathan R, Leipsic, Jonathon A, Son, Jang-Won, Sellers, Stephanie L, Shao, Michael, Blanke, Philipp, Ahmadi, Amir, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de Araujo Goncalves, Pedio, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Chinnaiyan, Kavitha, Raff, Gilbert, Al-Mallah, Mouaz H, Lin, Fay Y, Min, James K, Sung, Ji Min, Lee, Sang-Eun, and Chang, Hyuk-Jae

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Biomedical Imaging, Heart Disease, Cardiovascular, Heart Disease - Coronary Heart Disease, Atherosclerosis, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Disease Progression, Humans, Plaque, Atherosclerotic, Predictive Value of Tests, Risk Factors, Vascular Calcification, atherosclerosis, coronary artery calcium, coronary artery disease, coronary computed tomography angiography, statins, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThe aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease.BackgroundCoronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in response to medical therapy.MethodsThis analysis included 925 patients with 2,568 lesions from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry, in which patients underwent clinically indicated serial coronary computed tomography angiography. Plaque calcification was examined by using CPV and percent CPV (PCPV), calculated as (CPV/plaque volume) × 100 at a per-plaque and per-patient level (summation of all individual plaques).ResultsCPV was strongly correlated with plaque volume (r = 0.780; p

Published
2021

23. Predictors and 5-Year Clinical Outcomes of Pacemaker After TAVR

Author

Chen, Shmuel, primary, Dizon, Jose M., additional, Hahn, Rebecca T., additional, Pibarot, Philippe, additional, George, Isaac, additional, Zhao, Yanglu, additional, Blanke, Philipp, additional, Kapadia, Samir, additional, Babaliaros, Vasilis, additional, Szeto, Wilson Y., additional, Makkar, Raj, additional, Thourani, Vinod H., additional, Webb, John G., additional, Mack, Michael J., additional, Leon, Martin B., additional, Kodali, Susheel, additional, and Nazif, Tamim M., additional

Published
2024
Full Text
View/download PDF

29. One-Year Outcomes of Transseptal Mitral Valve-in-Valve in Intermediate Surgical Risk Patients.

Author

Malaisrie, S. Chris, Guerrero, Mayra, Davidson, Charles, Williams, Mathew, de Brito, Fábio Sândoli, Abizaid, Alexandre, Shah, Pinak, Tsuyoshi Kaneko, Poon, Karl, Levisay, Justin, Xiao Yu, Pibarot, Philippe, Hahn, Rebecca T., Blanke, Philipp, Leon, Martin B., Mack, Michael J., and Zajarias, Alan

Abstract

BACKGROUND: Transcatheter mitral valve-in-valve replacement offers a less-invasive alternative for high-risk patients with bioprosthetic valve failure. Limited experience exists in intermediate-risk patients. We aim to evaluate 1-year outcomes of the PARTNER 3 mitral valve-in-valve study. METHODS: This prospective, single-arm, multicenter study enrolled symptomatic patients with a failing mitral bioprosthesis demonstrating greater than or equal to moderate stenosis and regurgitation and Society of Thoracic Surgeons score ≥3% and <8%. A balloon-expandable transcatheter heart valve (SAPIEN 3, Edwards Lifesciences) was used via a transeptal approach. The primary end point was the composite of all-cause mortality and stroke at 1 year. RESULTS: A total of 50 patients from 12 sites underwent mitral valve-in-valve from 2018 to 2021. The mean age was 70.1±9.7 years, mean Society of Thoracic Surgeons score was 4.1%±1.6%, and 54% were female. There were no primary end point events (mortality or stroke) through 1 year, and no left-ventricular outflow tract obstruction, endocarditis, or mitral valve reintervention was reported. Six patients (12%) required rehospitalization, including heart failure (n=2), minor procedural side effects (n=2), and valve thrombosis (n=2; both resolved with anticoagulation). An additional valve thrombosis was associated with no significant clinical sequelae. From baseline to 1 year, all subjects with available data had none/trace or mild (grade 1+) mitral regurgitation and the New York Heart Association class improved in 87.2% (41/47) of patients. CONCLUSIONS: Mitral valve-in-valve with a balloon-expandable valve via transseptal approach in intermediate-risk patients was associated with improved symptoms and quality of life, adequate transcatheter valve performance, and no mortality or stroke at 1-year follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography Results of the PARADIGM Study

Author

Kim, Ung, Leipsic, Jonathon A, Sellers, Stephanie L, Shao, Michael, Blanke, Philipp, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Min, James K, and Chang, Hyuk-Jae

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Cardiovascular, Atherosclerosis, Prevention, Clinical Research, Heart Disease, Diabetes, Heart Disease - Coronary Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Diabetic Angiopathies, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prognosis, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Sex Factors, Time Factors, computed tomography, coronary artery disease, diabetes mellitus, plaque, progression, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThis study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM).BackgroundThe natural history of coronary PP in patients with DM is not well established.MethodsA total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and analyzed from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) trial. Study endpoints were changes in plaque features in diabetics with PP and risk factors for PP by serial coronary computed tomography angiography between patients with and without DM. PP was defined if plaque volume at follow-up minus plaque volume at baseline was >0.ResultsDM was an independent risk factor for PP (84.6%; 276 of 326 patients with PP) in multivariate analysis (odds ratio [OR]: 1.526; 95% confidence interval [CI]: 1.100 to 2.118; p = 0.011). Independent risk factors for PP in patients with DM were male sex (OR: 1.485; 95% CI: 1.003 to 2.199; p = 0.048) and mean plaque burden at baseline ≥75% (OR: 3.121; 95% CI: 1.701 to 5.725; p ≤0.001). After propensity matching, percent changes in overall plaque volume (30.3 ± 36.9% in patients without DM and 36.0 ± 29.7% in those with DM; p = 0.032) and necrotic core volume (-7.0 ± 35.8% in patients without DM and 21.5 ± 90.5% in those with DM; p = 0.007) were significantly greater in those with DM. The frequency of spotty calcification, positive remodeling, and burden of low-attenuation plaque were significantly greater in patients with DM.ConclusionsPeople with DM experience greater PP, particularly significantly greater progression in adverse plaque, than those without DM. Male sex and mean plaque burden >75% at baseline were identified as independent risk factors for PP.

Published
2018

33. Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy.

Author

Weir-McCall, Jonathan R, Blanke, Philipp, Sellers, Stephanie L, Ahmadi, Amir A, Andreini, Daniele, Budoff, Matthew J, Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, Gottlieb, Ilan, Hadamitzky, Martin, Kim, Yong Jin, Lee, Byoung Kwon, Lee, Sang-Eun, Maffei, Erica, Marques, Hugo, Pontone, Gianluca, Raff, Gilbert L, Shin, Sanghoon, Sung, Ji Min, Stone, Peter, Samady, Habib, Virmani, Renu, Narula, Jagat, Berman, Daniel S, Shaw, Leslee J, Bax, Jeroen J, Lin, Fay Y, Min, James K, Chang, Hyuk-Jae, and Leipsic, Jonathon A

Subjects
Coronary Vessels, Humans, Coronary Stenosis, Disease Progression, Fibrosis, Necrosis, Coronary Angiography, Severity of Illness Index, Registries, Prevalence, Multivariate Analysis, Linear Models, Risk Assessment, Risk Factors, Chi-Square Distribution, Predictive Value of Tests, Time Factors, Aged, Middle Aged, Female, Male, Coronary Artery Disease, Plaque, Atherosclerotic, Vascular Calcification, Computed Tomography Angiography, Coronary computed tomography angiography, Left main coronary artery disease, Natural history, Cardiovascular System & Hematology, Clinical Sciences, Cardiorespiratory Medicine and Haematology
Abstract

BACKGROUND:The aim of the study is examine the impact of non-obstructive (

Published
2018

35. Resumen: Consenso internacional para la nomenclatura y clasificación de la válvula aórtica bicúspide congénita y su aortopatía, con fines clínicos, quirúrgicos, intervencionistas y de investigación

Author

Michelena, Hector I., primary, della Corte, Alessandro, additional, Evangelista, Arturo, additional, Maleszewski, Joseph J., additional, Edwards, William D., additional, Roman, Mary J., additional, Devereux, Richard B., additional, Fernández, Borja, additional, Asch, Federico M., additional, Barker, Alex J., additional, Sierra, Lilia M., additional, de Kerchove, Laurent, additional, Fernandes, Susan M., additional, Fedak, Paul W.M., additional, Girdauskas, Evaldas, additional, Delgado, Victoria, additional, Abbara, Suhny, additional, Lansac, Emmanuel, additional, Prakash, Siddharth K., additional, Bissell, Malenka M., additional, Popescu, Bogdan A., additional, Hope, Michael D., additional, Sitges, Marta, additional, Thourani, Vinod H., additional, Pibarot, Phillippe, additional, Chandrasekaran, Krishnaswamy, additional, Lancellotti, Patrizio, additional, Borger, Michael A., additional, Forrest, John K., additional, Webb, John, additional, Milewicz, Dianna M., additional, Makkar, Raj, additional, Leon, Martin B., additional, Sanders, Stephen P., additional, Markl, Michael, additional, Ferrari, Victor A., additional, Roberts, William C., additional, Song, Jae-Kwan, additional, Blanke, Philipp, additional, White, Charles S., additional, Siu, Samuel, additional, Svensson, Lars G., additional, Braverman, Alan C., additional, Bavaria, Joseph, additional, Sundt, Thoralf M., additional, El Khoury, Gebrine, additional, de Paulis, Ruggero, additional, Enriquez-Sarano, Maurice, additional, Bax, Jeroen J., additional, Otto, Catherine M., additional, and Schäfers, Hans-Joachim, additional

Published
2024
Full Text
View/download PDF

36. Transcatheter Mitral Valve-in-Valve Replacement in the Presence of Pannus

Author

Jelisejevas, Julius, primary, Husain, Ali, additional, Dundas, James, additional, Chiang, Brian, additional, Akodad, Mariama, additional, Zaky, Fady, additional, Sathananthan, Gnalini, additional, Wood, David A., additional, Leipsic, Jonathon A., additional, Blanke, Philipp, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Meier, David, additional, and Webb, John G., additional

Published
2024
Full Text
View/download PDF

37. Abstract 10740: Effects of Renin-Angiotensin-Aldosterone-System Inhibitors on Coronary Atherosclerotic Plaques: Results From the Paradigm Registry

Author

Williams, Curtis, Han, Donghee, Takagi, Hidenobu, Fordyce, Christopher, Sellers, Stephanie, Blanke, Philipp, Lin, Fay Y, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Prof. Dr. Filippo, Chinnaiyan, Kavitha M, Conte, Edoardo, Marques, Hugo, Gottlieb, Ilan, Hadamitzky, Martin, Shin, Sanghoon, Lee, Byoung Kwon, Virmani, Renu, Samady, Habib, Choi, Jung Hyun, Berman, Daniel, Narula, Jagat, Bax, Jeroen J, Leipsic, Jonathon, and Chang, Hyuk-Jae

Published
2022
Full Text
View/download PDF

40. Prosthesis-Patient Mismatch After Aortic Valve Replacement in the PARTNER 2 Trial and Registry

Author

Ternacle, Julien, Pibarot, Philippe, Herrmann, Howard C., Kodali, Susheel, Leipsic, Jonathon, Blanke, Philipp, Jaber, Wael, Mack, Michael J., Clavel, Marie-Annick, Salaun, Erwan, Guzzetti, Ezequiel, Annabi, Mohamed-Salah, Bernier, Mathieu, Beaudoin, Jonathan, Khalique, Omar K., Weissman, Neil J., Douglas, Pamela, Bax, Jeroen, Dahou, Abdellaziz, Xu, Ke, Alu, Maria, Rogers, Erin, Leon, Martin, Thourani, Vinod H., Abbas, Amr E., and Hahn, Rebecca T.

Published
2021
Full Text
View/download PDF

41. Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research

Author

Généreux, Philippe, Piazza, Nicolo, Alu, Maria C., Nazif, Tamim, Hahn, Rebecca T., Pibarot, Philippe, Bax, Jeroen J., Leipsic, Jonathon A., Blanke, Philipp, Blackstone, Eugene H., Finn, Matthew T., Kapadia, Samir, Linke, Axel, Mack, Michael J., Makkar, Raj, Mehran, Roxana, Popma, Jeffrey J., Reardon, Michael, Rodes-Cabau, Josep, Van Mieghem, Nicolas M., Webb, John G., Cohen, David J., and Leon, Martin B.

Published
2021
Full Text
View/download PDF

42. Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk

Author

Leon, Martin B., Mack, Michael J., Hahn, Rebecca T., Thourani, Vinod H., Makkar, Raj, Kodali, Susheel K., Alu, Maria C., Madhavan, Mahesh V., Chau, Katherine H., Russo, Mark, Kapadia, Samir R., Malaisrie, S. Chris, Cohen, David J., Blanke, Philipp, Leipsic, Jonathon A., Williams, Mathew R., McCabe, James M., Brown, David L., Babaliaros, Vasilis, Goldman, Scott, Herrmann, Howard C., Szeto, Wilson Y., Genereux, Philippe, Pershad, Ashish, Lu, Michael, Webb, John G., Smith, Craig R., and Pibarot, Philippe

Published
2021
Full Text
View/download PDF

44. Predictive Value of Age- and Sex-Specific Nomograms of Global Plaque Burden on Coronary Computed Tomography Angiography for Major Cardiac Events

Author

Naoum, Christopher, Berman, Daniel S, Ahmadi, Amir, Blanke, Philipp, Gransar, Heidi, Narula, Jagat, Shaw, Leslee J, Kritharides, Leonard, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin, Cury, Ricardo C, DeLago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Maffei, Erica, Marquez, Hugo, Pontone, Gianluca, Raff, Gilbert, Rubinshtein, Ronen, Villines, Todd C, Min, James, and Leipsic, Jonathon

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease - Coronary Heart Disease, Heart Disease, Atherosclerosis, Biomedical Imaging, Cardiovascular, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Adult, Age Factors, Aged, Canada, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Europe, Female, Humans, Male, Middle Aged, Multidetector Computed Tomography, Nomograms, Plaque, Atherosclerotic, Predictive Value of Tests, Prevalence, Prognosis, Prospective Studies, Registries, Reproducibility of Results, Republic of Korea, Risk Factors, Severity of Illness Index, Sex Factors, United States, computed tomography angiography, coronary artery disease, coronary angiography, epidemiology, nomograms, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Age-adjusted coronary artery disease (CAD) burden identified on coronary computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack of nomographic data. We aimed to develop clinically pragmatic age- and sex-specific nomograms of CAD burden using coronary computed tomography angiography and to validate their prognostic use. Patients prospectively enrolled in phase I of the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes) were included (derivation cohort: n=21,132; 46% female) to develop CAD nomograms based on age-sex percentiles of segment involvement score (SIS) at each year of life (40-79 years). The relationship between SIS age-sex percentiles (SIS%) and MACE (all-cause death, myocardial infarction, unstable angina, and late revascularization) was tested in a nonoverlapping validation cohort (phase II, CONFIRM registry; n=3030, 44% female) by stratifying patients into 3 SIS% groups (≤50th, 51-75th, and >75th) and comparing annualized MACE rates and time to MACE using multivariable Cox proportional hazards models adjusting for Framingham risk and chest pain typicality. Age-sex percentiles were well fitted to second-order polynomial curves (men: R2=0.86±0.12; women: R2=0.86±0.14). Using the nomograms, there were 1576, 965, and 489 patients, respectively, in the ≤50th, 51-75th, and >75th SIS% groups. Annualized event rates were higher among patients with greater CAD burden (2.1% [95% confidence interval: 1.7%-2.7%], 3.9% [95% confidence interval: 3.0%-5.1%], and 7.2% [95% confidence interval: 5.4%-9.6%] in ≤50th, 51-75th, and >75th SIS% groups, respectively; P75th SIS% group; P

Published
2017

45. Long-Term Prognostic Utility of Coronary CT Angiography in Stable Patients With Diabetes Mellitus

Author

Blanke, Philipp, Naoum, Christopher, Ahmadi, Amir, Cheruvu, Chaitu, Soon, Jeanette, Arepalli, Chesnal, Gransar, Heidi, Achenbach, Stephan, Berman, Daniel S, Budoff, Matthew J, Callister, Tracy Q, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Rubinshtein, Ronen, Marquez, Hugo, DeLago, Augustin, Villines, Todd C, Hadamitzky, Martin, Hausleiter, Joerg, Shaw, Leslee J, Kaufmann, Philipp A, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Maffei, Erica, Raff, Gilbert, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Chow, Benjamin W, Min, James, and Leipsic, Jonathon

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Biomedical Imaging, Heart Disease - Coronary Heart Disease, Atherosclerosis, Heart Disease, Clinical Research, Diabetes, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Metabolic and endocrine, Good Health and Well Being, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Diabetes Mellitus, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multidetector Computed Tomography, Multivariate Analysis, Predictive Value of Tests, Prevalence, Prognosis, Propensity Score, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Severity of Illness Index, Time Factors, coronary CT angiography, diabetes mellitus, prognosis, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThe goal of this study was to determine the long-term prognostic value of coronary computed tomography angiography (CTA) among patients with diabetes mellitus (DM) compared with nondiabetic subjects.BackgroundThe long-term prognostic value of coronary CTA in patients with DM is not well established.MethodsPatients enrolled in the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry with 5-year follow-up data were identified. The extent and severity of coronary artery disease (CAD) were analyzed at baseline coronary CTA and in relation to outcomes between diabetic and nondiabetic patients. CAD according to coronary CTA was defined as none (0% stenosis), nonobstructive (1% to 49% stenosis), or obstructive (≥50% stenosis). Time to death (and in a subgroup, time to major adverse cardiovascular event) was estimated by using multivariable Cox proportional hazards models.ResultsA total of 1,823 patients were identified as having DM with 5-year clinical follow-up and were propensity-matched to 1,823 patients without DM (mean age 61.8 ± 10.9 years; 54.4% male). Patients with DM did not exhibit a heightened risk of death compared with the propensity-matched nondiabetic subjects in the absence of CAD on coronary CTA (risk-adjusted hazard ratio [HR] of DM: 1.32; 95% confidence interval [CI]: 0.78 to 2.24; p = 0.296). Patients with DM were at increased risk of dying compared with nondiabetic subjects in the setting of nonobstructive CAD (in the propensity-matched cohort: HR, 2.10; 95% CI: 1.43 to 3.09; p < 0.001) with a mortality risk greater than nondiabetic subjects with obstructive disease (p < 0.001). In a risk-adjusted hazard analysis among patients with DM, both per-patient obstructive CAD and nonobstructive CAD conferred an increase in all-cause mortality risk compared with patients without atherosclerosis on coronary CTA (nonobstructive disease-HR: 2.07; 95% CI: 1.33 to 3.24; p = 0.001; obstructive disease-HR: 2.22; 95% CI: 1.47 to 3.36; p < 0.001).ConclusionsAmong patients with DM, nonobstructive and obstructive CAD according to coronary CTA were associated with higher rates of all-cause mortality and major adverse cardiovascular events at 5 years, and this risk was significantly higher than in nondiabetic subjects. Importantly, patients with DM without CAD according to coronary CTA were at a risk comparable to that of nondiabetic subjects.

Published
2016

46. Transcatheter Replacement of Transcatheter Versus Surgically Implanted Aortic Valve Bioprostheses

Author

Landes, Uri, Sathananthan, Janarthanan, Witberg, Guy, De Backer, Ole, Sondergaard, Lars, Abdel-Wahab, Mohamed, Holzhey, David, Kim, Won-Keun, Hamm, Christian, Buzzatti, Nicola, Montorfano, Matteo, Ludwig, Sebastian, Conradi, Lenard, Seiffert, Moritz, Guerrero, Mayra, El Sabbagh, Abdallah, Rodés-Cabau, Josep, Guimaraes, Leonardo, Codner, Pablo, Okuno, Taishi, Pilgrim, Thomas, Fiorina, Claudia, Colombo, Antonio, Mangieri, Antonio, Eltchaninoff, Helene, Nombela-Franco, Luis, Van Wiechen, Maarten P.H., Van Mieghem, Nicolas M., Tchétché, Didier, Schoels, Wolfgang H., Kullmer, Matthias, Tamburino, Corrado, Sinning, Jan-Malte, Al-Kassou, Baravan, Perlman, Gidon Y., Danenberg, Haim, Ielasi, Alfonso, Fraccaro, Chiara, Tarantini, Giuseppe, De Marco, Federico, Redwood, Simon R., Lisko, John C., Babaliaros, Vasilis C., Laine, Mika, Nerla, Roberto, Castriota, Fausto, Finkelstein, Ariel, Loewenstein, Itamar, Eitan, Amnon, Jaffe, Ronen, Ruile, Philipp, Neumann, Franz J., Piazza, Nicolo, Alosaimi, Hind, Sievert, Horst, Sievert, Kolja, Russo, Marco, Andreas, Martin, Bunc, Matjaz, Latib, Azeem, Godfrey, Rebecca, Hildick-Smith, David, Chuang, Ming-Yu A., Blanke, Philipp, Leipsic, Jonathon, Wood, David A., Nazif, Tamim M., Kodali, Susheel, Barbanti, Marco, Kornowski, Ran, Leon, Martin B., and Webb, John G.

Published
2021
Full Text
View/download PDF

49. Comparison of Coronary Atherosclerotic Plaque Progression in East Asians and Caucasians by Serial Coronary Computed Tomographic Angiography:A PARADIGM Substudy

Author

Ben Zekry, Sagit, Sreedharan, Subhashaan, Han, Donghee, Sellers, Stephanie, Ahmadi, Amir A., Blanke, Philipp, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J., Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H., Berman, Daniel S., Narula, Jagat, Shaw, Leslee J., Bax, Jeroen J., Leipsic, Jonathon, and Chang, Hyuk-Jae

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results