239 results on '"Blagg, Brian S. J."'
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2. The Investigation of Hsp90C‐Terminal Inhibitors Containing Amide Bioisosteres.
3. The Right Tool for the Job: An Overview of Hsp90 Inhibitors
4. A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
5. Evaluation of the Mammalian Aquaporin Inhibitors Auphen and Z433927330 in Treating Breast Cancer.
6. Anti-inflammatory activities of novel heat shock protein 90 isoform selective inhibitors in BV-2 microglial cells.
7. Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target
8. Hsp90 activator Aha1 drives production of pathological tau aggregates
9. Synthesis and Validation of the First Cell-Impermeable Hsp90α-Selective Inhibitors
10. Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities.
11. CryoEM Structure with ATP Synthase Enables Late‐Stage Diversification of Cruentaren A
12. Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activitiesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00529a
13. Enniatin A Analogues as Novel Hsp90 Inhibitors that Modulate Triple-Negative Breast Cancer.
14. A Split Renilla Luciferase Complementation Assay for the Evaluation of Hsp90/Aha1 Complex Disruptors and Their Activity at the Aha1 C-Terminal Domain
15. Structure–Activity Relationship Study of Tertiary Alcohol Hsp90α-Selective Inhibitors with Novel Binding Mode
16. Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors
17. Synthesis and Evaluation of Simplified Cruentaren A Analogues
18. Syntheses of Symmetrical and Unsymmetrical Lysobisphosphatidic Acid Derivatives
19. The biology and inhibition of glucose‐regulated protein 94/gp96
20. CryoEM Structure with ATP Synthase Enables Late-Stage Diversification of Cruentaren A.
21. Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation
22. A Split Renilla Luciferase Complementation Assay for the Evaluation of Hsp90/Aha1 Complex Disruptors and Their Activity at the Aha1 C‑Terminal Domain.
23. QSAR Studies to Predict Activity of HSP90 Inhibitors
24. Structure‐Based Design, Synthesis, and Biological Evaluation of Hsp90β‐Selective Inhibitors
25. Novologue Therapy Requires Heat Shock Protein 70 and Thioredoxin-Interacting Protein to Improve Mitochondrial Bioenergetics and Decrease Mitophagy in Diabetic Sensory Neurons
26. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma
27. A Split RenillaLuciferase Complementation Assay for the Evaluation of Hsp90/Aha1 Complex Disruptors and Their Activity at the Aha1 C-Terminal Domain
28. Selective Inhibition of the Hsp90α Isoform
29. Biological Evaluation of 5′-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors
30. The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition
31. Synthesis and Evaluation of Ginkgolic Acid Derivatives as SUMOylation Inhibitors
32. Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations
33. The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies
34. Current Status of SUMOylation Inhibitors
35. From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition
36. Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors
37. Novel C‐terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self‐renewal, and epithelial–mesenchymal transition
38. Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway
39. Identification of the Hsp90 Isoforms and Co‐Chaperones that Repress Opioid Anti‐Nociception in the Spinal Cord
40. Catalysis-Enabled Access to Cryptic Geldanamycin Oxides
41. Mitochondrial-targeted Hsp90 C-terminal Inhibitors that Manifest Anticancer Activities
42. The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain
43. An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol
44. The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor
45. The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies.
46. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding
47. Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma
48. Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
49. Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain
50. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
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