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Your search keyword '"Bigley, Nancy A."' showing total 7 results
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7 results on '"Bigley, Nancy A."'

1. BROAD STROKES AND GRANULAR DETAILS: Bottle & Bottega co-founder and new Painting with a Twist COO discusses the sale of her brand to a former competitor

Author

Bigley, Nancy

Subjects
Business owners, Franchises, Chief operating officers, Private equity, Advertising, marketing and public relations, Business, Economics
Abstract

As a business owner, you should be asking yourself several questions: What resources you have in terms of people and money, how can you grow to where you want to [...]

Published
2019

3. The role of the IFA Women's Franchise Committee in franchising: with 20 chapters throughout the country, the committee inspires female sector leaders to share wisdom and leadership with female franchisees, franchisors and suppliers throughout the year

Author

Bigley, Nancy

Subjects
Franchises, Women executives, Leadership, Advertising, marketing and public relations, Business, Economics
Abstract

The mission of the IFA Women's Franchise Committee is to 'empower leaders in franchising by promoting women's participation in the industry and providing international networking opportunities for the exchange of [...]

Published
2017

7. A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus.

Author

Ahmed, Chulbul M., Dabelic, Rea, Bedoya, Simone Kennedy, Larkin III, Joseph, Johnson, Howard M., Metzger, Dennis, and Bigley, Nancy Jane

Subjects
ANTIVIRAL agents, SUPPRESSORS of cytokine signaling, INFLUENZA A virus
Abstract

We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001-1013), which corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized pJAK2(1001-1013) inhibits SOCS1 and SOCS3. SOCS1 has been shown to be an influenza virus-induced virulence factor that enhances infection of cells. The antagonist was protective in cell culture and in influenza virus PR8 lethally infected C57BL/6 mice. The SOCS antagonist also prevented adverse morbidity as assessed by parameters, such as weight loss and drop in body temperature, and showed potent induction of both the cellular and humoral immune responses to the influenza virus candidate universal antigen matrix protein 2 (M2e). The SOCS antagonist, thus, protected mice against lethal influenza virus infection and possessed potent adjuvancy against the M2e candidate influenza virus universal vaccine antigen. [ABSTRACT FROM AUTHOR]

Published
2015
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