1. Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants
- Author
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Barbara Schmidt, Robin S. Roberts, Peter G. Davis, Lex W. Doyle, Elizabeth V. Asztalos, Gillian Opie, Aida Bairam, Alfonso Solimano, Shmuel Arnon, Reginald S. Sauve, Judy D'Ilario, Janice Cairnie, Joanne Dix, Beth Anne Adams, Erin Warriner, Mee-Hai Marie Kim, Peter Anderson, Peter Davis, Lex Doyle, Brenda Argus, Catherine Callanan, Noni Davis, Julianne Duff, Marion McDonald, Elizabeth Asztalos, Denise Hohn, Maralyn Lacy, Ross Haslam, Christopher Barnett, Louise Goodchild, Rosslyn Marie Lontis, Simon Fraser, Julie Keng, Kerryn Saunders, Elaine Kelly, Heather Woods, Emma Marchant, Anne-Marie Turner, Emma Magrath, Amanda Williamson, Sylvie Bélanger, Annie Fraser, Marc Blayney, Brigitte Lemyre, Jane Frank, Anne Synnes, Ruth E. Grunau, Philippa Hubber-Richard, Marilyn Rogers, Margot Mackay, Julianne Petrie-Thomas, Arsalan Butt, Aleid van Wassenaer, Debbie Nuytemans, Bregje Houtzager, Loekie van Sonderen, Rivka Regev, Netter Itzchack, Adiba Chalaf, Arne Ohlsson, Karel O'Brien, Anne-Marie Hamilton, May Lee Chan, Koravangattu Sankaran, Pat Proctor, Agneta Golan, Esther Goldsch-Lerman, Graham Reynolds, Barbara Dromgool, Sandra Meskell, Vanessa Parr, Catherine Maher, Margaret Broom, Zsuzsoka Kecskes, Cathy Ringland, Douglas McMillan, Elizabeth Spellen, Heather Christianson, Deborah Anseeuw-Deeks, Dianne Creighton, Jennifer Heath, Ruben Alvaro, Aaron Chiu, Ceceile Porter, Gloria Turner, Diane Moddemann, Naomi Granke, Karen Penner, Jane Bow, Antonius Mulder, Renske Wassenberg, Markus van der Hoeven, Maxine Clarke, Judy Parfitt, Kevin Parker, Chukwuma Nwaesei, Heather Ryan, Cory Saunders, Andreas Schulze, Inga Wermuth, Anne Hilgendorff, Andreas W. Flemmer, Eric Herlenius, Lena Legnevall, Hugo Lagercrantz, Derek Matthew, Wendy Amos, Suresh Tulsiani, Cherrie Tan-Dy, Marilyn Turner, Constance Phelan, Eric S. Shinwell, Michael Levine, Ada Juster-Reicher, May Khairy, Patricia Grier, Julie Vachon, Larissa Perepolkin, Keith J. Barrington, Sunil Kumar Sinha, Win Tin, Susan Fritz, Herve Walti, Diane Royer, Henry Halliday, David Millar, Clifford Mayes, Christopher McCusker, Olivia McLaughlin, Hubert Fahnenstich, Bettina Tillmann, Peter Weber, Unni Wariyar, Nicholas Embleton, Ravi Swamy, Hans U. Bucher, Jean-Claude Fauchere, Vera Dietz, Chidambara Harikumar, Peter J. Anderson, Deborah Dewey, Michael Gent, William Fraser, Edmund Hey, Max Perlman, Kevin Thorpe, Shari Gray, Carole Chambers, Lorrie Costantini, Wendy Yacura, Erin McGean, Lori Scapinello, Kindergeneeskunde, RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, University of Zurich, Schmidt, Barbara, Other Research, Neonatology, and Child and Adolescent Psychiatry & Psychosocial Care
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Health Status ,Leukomalacia, Periventricular ,610 Medicine & health ,Child Behavior Disorders ,Deafness ,Blindness ,Cerebral Ventricles ,medicine ,Humans ,Infant, Very Low Birth Weight ,Disabled Persons ,Retinopathy of Prematurity ,2735 Pediatrics, Perinatology and Child Health ,Apnea of prematurity ,Bronchopulmonary Dysplasia ,medicine.diagnostic_test ,business.industry ,Cysts ,Postmenstrual Age ,Infant, Newborn ,Apnea ,Retinopathy of prematurity ,medicine.disease ,10027 Clinic for Neonatology ,Prognosis ,Echoencephalography ,Oxygen ,Low birth weight ,Treatment Outcome ,Bronchopulmonary dysplasia ,Brain Injuries ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,Morbidity ,business ,Cognition Disorders ,Infant, Premature ,Ventriculomegaly ,Follow-Up Studies - Abstract
Objective To evaluate bronchopulmonary dysplasia (BPD), serious brain injury, and severe retinopathy of prematurity (ROP) as predictors of poor long-term outcome in very low birth weight infants. Study design We examined the associations between counts of the 3 morbidities and long-term outcomes in 1514 of 1791 (85%) infants with birth weights of 500-1250 g who were enrolled in the Caffeine for Apnea of Prematurity trial from October 1999, to October 2004, had complete morbidity data, and were alive at 36 weeks postmenstrual age (PMA). BPD was defined as use of supplemental oxygen at 36 weeks PMA. Serious brain injury on cranial ultrasound included grade 3 and 4 hemorrhage, cystic periventricular leucomalacia, porencephalic cysts, or ventriculomegaly of any cause. Poor long-term outcome was death after 36 weeks PMA or survival to 5 years with 1 or more of the following disabilities: motor impairment, cognitive impairment, behavior problems, poor general health, deafness, and blindness. Results BPD, serious brain injury, and severe ROP occurred in 43%, 13%, and 6% of the infants, respectively. Each of the 3 morbidities was similarly and independently correlated with poor 5-year outcome. Rates of death or disability (95% CI) in children with none, any 1, any 2, and all 3 morbidities were 11.2% (9.0%-13.7%), 22.9% (19.6%-26.5%), 43.9% (35.5%-52.6%), and 61.5% (40.6%-79.8%), respectively. Conclusions In very low birth weight infants who survive to 36 weeks PMA, a count of BPD, serious brain injury, and severe ROP predicts the risk of a late death or survival with disability at 5 years.
- Published
- 2015