Search

Your search keyword '"Bentes, Carla"' showing total 211 results
Start Over Author "Bentes, Carla" Publication Year Range Last 10 years
211 results on '"Bentes, Carla"'

4. Implications for driving based on the risk of seizures after ischaemic stroke

Author

Schubert, Kai Michael, primary, Bicciato, Giulio, additional, Sinka, Lucia, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Terziev, Robert, additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J, additional, Wagner, Judith N, additional, Gigli, Gian Luigi, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Mayor-Romero, Luis Carlos, additional, Conrad, Julian, additional, Evers, S, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R, additional, Duncan, John Sidney, additional, Sander, Josemir W, additional, Tettenborn, Barbara, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2024
Full Text
View/download PDF

5. Factors associated with failed epidural blood patch after accidental dural puncture in obstetrics: a prospective, multicentre, international cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean., Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Mercier, Frederic, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen, Truong Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Stamelos, Mattheios, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manuel, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintaric, Tatjana, Chiquito, Teresa, Monedero, Pablo, De Carlos-Errea, Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Jörnvall, Henrik, Nordström, Johan, Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Daamen, Sylvia, Farsi, Slama, Feijten, Prisca, Harlet, Pierre, Leva, Brigitte, Plichon, Benoît, Magnuson, Anders, Guasch, Emilia, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2022
Full Text
View/download PDF

7. Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry.

Author

Kaufmann, Elisabeth, Peltola, Jukka, Colon, Albert J., Lehtimäki, Kai, Majtanik, Milan, Mai, Jürgen K., Bóné, Beata, Bentes, Carla, Coenen, Volker, Gil‐Nagel, Antonio, Goncalves‐Ferreira, Antonio J., Ryvlin, Philippe, Taylor, Rod, Brionne, Thomas C., Gielen, Frans, Song, Shannon, and Boon, Paul

Subjects
DEEP brain stimulation, PARTIAL epilepsy, EPILEPSY surgery, NEURAL stimulation, EPILEPSY, BRAIN stimulation, TEMPORAL lobectomy
Abstract

Objective: Short‐term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT‐DBS) were reported for people with drug‐resistant focal epilepsy (PwE). Because long‐term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT‐DBS. Methods: In this multicenter registry, PwE with ANT‐DBS were followed up for safety, efficacy, and battery longevity. Follow‐up ended after 5 years or upon study closure. Clinical characteristics and stimulation settings were compared between PwE with no benefit, improvers, and responders, that is, PwE with average monthly seizure frequency reduction rates of ≥50%. Results: Of 170 eligible PwE, 104, 62, and 49 completed the 3‐, 4‐, and 5‐year follow‐up, respectively. Most discontinuations (68%) were due to planned study closure as follow‐up beyond 2 years was optional. The 5‐year follow‐up cohort had a median seizure frequency reduction from 16 per month at baseline to 7.9 per month at 5‐year follow‐up (p <.001), with most‐pronounced effects on focal‐to‐bilateral tonic–clonic seizures (n = 15, 77% reduction, p =.008). At last follow‐up (median 3.5 years), 41% (69/170) of PwE were responders. Unifocal epilepsy (p =.035) and a negative history of epilepsy surgery (p =.002) were associated with larger average monthly seizure frequency reductions. Stimulation settings did not differ between response groups. In 179 implanted PwE, DBS‐related adverse events (AEs, n = 225) and serious AEs (n = 75) included deterioration in epilepsy or seizure frequency/severity/type (33; 14 serious), memory/cognitive impairment (29; 3 serious), and depression (13; 4 serious). Five deaths occurred (none were ANT‐DBS related). Most AEs (76.3%) manifested within the first 2 years after implantation. Activa PC depletion (n = 37) occurred on average after 45 months. Significance: MORE provides further evidence for the long‐term application of ANT‐DBS in clinical routine practice. Although clinical benefits increased over time, side effects occurred mainly during the first 2 years. Identified outcome modifiers can help inform PwE selection and management. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Molecular characterization of the circadian clock in patients with Parkinson's disease–CLOCK4PD Study protocol.

Author

Yalçin, Müge, Peralta, Ana Rita, Bentes, Carla, Silva, Cristiana, Guerreiro, Tiago, Ferreira, Joaquim J., and Relógio, Angela

Subjects
CIRCADIAN rhythms, PARKINSON'S disease, RESEARCH protocols, SLEEP, SLEEP interruptions, SEX (Biology), GENE expression profiling, DEEP brain stimulation
Abstract

Introduction: Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism's physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alterations at the molecular expression level for core-clock and clock-controlled genes in PD is still missing. Methods and analysis: The proposed study protocol will be used to characterize expression profiles of circadian genes obtained from saliva samples in PD patients and controls. For this purpose, 20 healthy controls and 70 PD patients will be recruited. Data from clinical assessment, questionnaires, actigraphy tracking and polysomnography will be collected and clinical evaluations will be repeated as a follow-up in one-year time. We plan to carry out sub-group analyses considering several clinical factors (e.g., biological sex, treatment dosages, or fluctuation of symptoms), and to correlate reflected changes in CR of measured genes with distinct PD phenotypes (diffuse malignant and mild/motor-predominant). Additionally, using NanoStringⓇ multiplex technology on a subset of samples, we aim to further explore potential CR alterations in hundreds of genes involved in neuropathology pathways. Discussion: CLOCK4PD is a mono-centric, non-interventional observational study aiming at the molecular characterization of CR alterations in PD. We further plan to determine physiological modifications in sleep and activity patterns, and clinical factors correlating with the observed CR changes. Our study may provide valuable insights into the intricate interplay between CR and PD with a potential to be used as a predictor of circadian alterations reflecting distinct disease phenotypes, symptoms, and progression outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean, Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Soued, Mickaël, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen Troung, Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Tsaroucha, Athanasia, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Morina, Qamile, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., Van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyaba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Tavares, Francisca, Vasconcelos, Pedro, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manue, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintraic, Tatjana, Chiquito, Teresa, Monedero, Pablo, Carlos-Errea, De Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Cendaña, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Nordstöm, Johan L., Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Magnuson, Anders, Fernando, Roshan, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2020
Full Text
View/download PDF

17. Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study

Author

Coelho, Pedro, primary, Madureira, João, additional, Franco, Ana, additional, Peralta, Ana Rita, additional, Bentes, Carla, additional, Campos, Alexandre Rainha, additional, Anink, Jasper, additional, Aronica, Eleonora, additional, Roque, Rafael, additional, and Pimentel, José, additional

Published
2023
Full Text
View/download PDF

23. Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate

Author

Koepp, Matthias J., primary, Trinka, Eugen, additional, Mah, Yee‐Haur, additional, Bentes, Carla, additional, Knake, Susanne, additional, Gigli, Gian Luigi, additional, Serratosa, José M., additional, Zelano, Johan, additional, Magalhães, Luís M., additional, Pereira, Ana, additional, Moreira, Joana, additional, and Soares‐da‐Silva, Patrício, additional

Published
2023
Full Text
View/download PDF

24. Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model

Author

Sinka, Lucia, primary, Abraira, Laura, additional, Imbach, Lukas L., additional, Zieglgänsberger, Dominik, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Terziev, Robert, additional, Simmen, Cyril, additional, Schubert, Kai Michael, additional, Elshahabi, Adham, additional, Baumann, Christian R., additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Bayona-Ortiz, Hernan, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional

Published
2023
Full Text
View/download PDF

25. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, Colon, Albert J., Pimentel, José, Coenen, Volker A., Gil-Nagel, Antonio, Gonçalves Ferreira, António, Lehtimäki, Kai, Ryvlin, Philippe, Taylor, Rod S., Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla, Bosak, Magdalena, Burneo, Jorge G., Chamadoira, Clara, Elger, Christian E., Erőss, Loránd, Fabo, Dániel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Järvenpää, Soila, Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew, Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana, Rácz, Attila, Rainha Campos, Alexandre, Rego, Ricardo, Ricciuti, Riccardo A., Rona, Sabine, Rouhl, Rob P.W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack, Abouihia, Abdallah, Brionne, Thomas C., Gielen, Frans, Boon, Paul A.J.M., Tampere University, Clinical Medicine, Department of Neurosciences and Rehabilitation, and Repositório da Universidade de Lisboa

Subjects
Medicine and Health Sciences, Neurology (clinical), 3124 Neurology and psychiatry
Abstract

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation. Classification of evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., The MORE registry was sponsored and funded by Medtronic, plc.

Published
2023

29. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Author

Ferreira-Atuesta, Carolina, primary, de Tisi, Jane, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, Khoury, Jean, additional, Yardi, Ruta, additional, Vegh, Deborah T, additional, Butler, James, additional, Lee, Hamin J, additional, Deli-Peri, Victoria, additional, Yao, Yi, additional, Wang, Feng-Peng, additional, Zhang, Xiao-Bin, additional, Shakhatreh, Lubna, additional, Siriratnam, Pakeeran, additional, Neal, Andrew, additional, Sen, Arjune, additional, Tristram, Maggie, additional, Varghese, Elizabeth, additional, Biney, Wendy, additional, Gray, William P, additional, Peralta, Ana Rita, additional, Rainha-Campos, Alexandre, additional, Gonçalves-Ferreira, António J C, additional, Pimentel, José, additional, Arias, Juan Fernando, additional, Terman, Samuel, additional, Terziev, Robert, additional, Lamberink, Herm J, additional, Braun, Kees P J, additional, Otte, Willem M, additional, Rugg-Gunn, Fergus J, additional, Gonzalez, Walter, additional, Bentes, Carla, additional, Hamandi, Khalid, additional, O'Brien, Terence J, additional, Perucca, Piero, additional, Yao, Chen, additional, Burman, Richard J, additional, Jehi, Lara, additional, Duncan, John S, additional, Sander, Josemir W, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2022
Full Text
View/download PDF

35. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke

Author

Mishra, Nishant K., primary, Engel, Jerome, additional, Liebeskind, David S., additional, Sharma, Vijay K., additional, Hirsch, Lawrence J., additional, Kasner, Scott E, additional, French, Jacqueline A., additional, Devinsky, Orrin, additional, Friedman, Alon, additional, Dawson, Jesse, additional, Quinn, Terence J., additional, Selim, Magdy, additional, de Havenon, Adam, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Benninger, Felix, additional, Zaveri, Hitten P., additional, Burneo, Jorge G., additional, Srivastava, Padma, additional, Bhushan Singh, Mamta, additional, Bhatia, Rohit, additional, Vishnu, V.Y., additional, Bentes, Carla, additional, Ferro, Jose, additional, Weiss, Shennan, additional, Sivaraju, Adithya, additional, Kim, Jennifer A., additional, Galovic, Marian, additional, Gilmore, Emily J., additional, Pitkänen, Asla, additional, Davis, Kathryn, additional, Sansing, Lauren H., additional, Sheth, Kevin N., additional, Paz, Jeanne T., additional, Singh, Anuradha, additional, Sheth, Sunil, additional, Worrall, Bradford B., additional, Grotta, James C., additional, Casillas-Espinos, Pablo M., additional, Chen, Zhibin, additional, Nicolo, John-Paul, additional, Yan, Bernard, additional, and Kwan, Patrick, additional

Published
2022
Full Text
View/download PDF

38. Sleep and awakening quality during COVID-19 confinement

Author

Paiva, Teresa, Reis, Cátia, Feliciano, Amélia, Canas-Simião, Hugo, Machado, Maria Augusta, Gaspar, Tânia, Tomé, Gina, Branquinho, Cátia, Silva, Maria Raquel, Ramiro, Lúcia, Gaspar, Susana, Bentes, Carla, Sampaio, Francisco, Pinho, Lara, Pereira, Conceição, Carreiro, Alexandra, Moreira, Susana, Luzeiro, Isabel, Pimentel, Joana, Videira, Gabriela, Fonseca, Júlio, Bernarda, Ana, Castro, Joana Vaz, Rebocho, Sofia, Almondes, Katie, Canhão, Helena, Matos, Margarida Gaspar, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Health-related behaviors, SDG 3 - Good Health and Well-being, Health, Attitudes, Health, Toxicology and Mutagenesis, Mood, Public Health, Environmental and Occupational Health, COVID-19, Dependences, Health professionals, Sleep patients, Sleep/awakening quality, Calamity Experience Check List
Abstract

Acknowledgments: Gina Tomé is a postdoctorate funded by the Fundação Ciência e Tecnologia (FCT) SFRH/BPD/108637/2015. Objective: The aim of this study was to evaluate sleep and awakening quality (SQ and AQ) during COVID-19 in a large and diversified population in order to identify significant associations and risks in terms of demography, health and health-related behaviors, sleep variables, mental health, and attitudes. Methods/Results:Online surveys were used for data collection, received from 5479 individuals from the general population, sleep disorder patients, and COVID-involved (medical doctors (MDs) and nurses) and COVID-affected professionals (teachers, psychologists, and dentists). SQ and AQ were worse in adults, females, and high-education subjects. Feeling worse, having economic problems, depression, anxiety, irritability, and a high Calamity Experience Check List (CECL) score during COVID were significantly associated with poor SQ and AQ. Shorter sleep duration, increased latency, poor nutrition, low physical activity, increased mobile and social network use, more negative and less positive attitudes and behaviors were associated with poor AQ. Conclusions: The SQ logistic regression showed gender, morbidities, CECL, and awakenings as relevant, whereas, for AQ, relevant variables further included age and physical activity. Aiming to have a high stress compliance, each individual should sleep well, have important control of their mood, practice positive behaviors while dismissing negative behaviors and attitudes, practice exercise, have adequate nutrition, and beware of technologies and dependences. publishersversion published

Published
2021

39. Seizures after Ischemic Stroke: A Matched Multicenter Study

Author

Ferreira‐Atuesta, Carolina, primary, Döhler, Nico, additional, Erdélyi‐Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Schweizer, Juliane, additional, Sinka, Lucia, additional, Imbach, Lukas L., additional, Katan, Mira, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez‐Sabín, José, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Gregoraci, Giorgia, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Melo, Teresa Pinho e, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional

Published
2021
Full Text
View/download PDF

41. A European questionnaire survey on epilepsy monitoring units' current practice for postoperative psychogenic nonepileptic seizures' detection

Author

Markoula, Sofia, Liampas, Andreas, Rubboli, Guido, Duncan, John, Velis, Demetrios N, Schulze-Bonhage, Andreas, Guekht, Alla, Bartholomeyczik, Karen, Tisi, Jane de, Gras, Adrien, Lossius, Morten Ingvar, Villani, Flavio, Staack, Anke Maren, Hospes, Annette, Baaijen, Johannes C., van Straaten, Elisabeth C.W., Ronner, Hanneke E., Casciato, Sara, D'Aniello, Alfredo, Mascia, Addolorata, Santos, Susana Ferrao, Bentes, Carla, Aledo-Serrano, Ángel, Gil-Nagel, Antonio, Dimova, Petia, Hećimović, Hrvoje, Özkara, Çiğdem, Malmgren, Kristina, Papacostas, Savvas, Kelemen, Anna, Reuber, Markus, Trinka, Eugen, and Ryvlin, Philippe

Published
2020
Full Text
View/download PDF

42. a challenging semiology

Author

Leal Rato, Miguel, Ionel, Cristina, Baduro, Yanina, Oliveira, Renato, Franco, Ana Catarina, Peralta, Ana Rita, Bentes, Carla, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Neurology, Clinical Neurology
Abstract

publishersversion published

Published
2020

44. Sleep and Awakening Quality during COVID-19 Confinement: Complexity and Relevance for Health and Behavior

Author

Paiva, Teresa, primary, Reis, Cátia, additional, Feliciano, Amélia, additional, Canas-Simião, Hugo, additional, Machado, Maria Augusta, additional, Gaspar, Tânia, additional, Tomé, Gina, additional, Branquinho, Cátia, additional, Silva, Maria Raquel, additional, Ramiro, Lúcia, additional, Gaspar, Susana, additional, Bentes, Carla, additional, Sampaio, Francisco, additional, Pinho, Lara, additional, Pereira, Conceição, additional, Carreiro, Alexandra, additional, Moreira, Susana, additional, Luzeiro, Isabel, additional, Pimentel, Joana, additional, Videira, Gabriela, additional, Fonseca, Júlio, additional, Bernarda, Ana, additional, Vaz Castro, Joana, additional, Rebocho, Sofia, additional, Almondes, Katie, additional, Canhão, Helena, additional, and Matos, Margarida Gaspar, additional

Published
2021
Full Text
View/download PDF

45. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Gupta, Anil, primary, von Heymann, Christian, additional, Magnuson, Anders, additional, Alahuhta, Seppo, additional, Fernando, Roshan, additional, Van de Velde, Marc, additional, Mercier, Frédéric J., additional, Schyns-van den Berg, Alexandra M.J.V., additional, Casier, Isabelle, additional, Bryon, Bart, additional, Soetens, Filiep, additional, Dewandre, Pierre-Yves, additional, Lambert, Geraldine, additional, Christiaen, Jan, additional, Schepers, Roel, additional, Van Houwe, Patrick, additional, Kalmar, Alain, additional, Vanoverschelde, Henk, additional, Bauters, Monique, additional, Roofthooft, Eva, additional, Devroe, Sarah, additional, Jadrijevic, Ana, additional, Jokic, Aleksandra, additional, Marin, Damjan, additional, Sklebar, Ivan, additional, Mihaljević, Slobodan, additional, Kosinova, Martina, additional, Stourac, Petr, additional, Adamus, Milan, additional, Kufa, Christian, additional, Volfová, Ivana, additional, Zaoralová, Blažena, additional, Froeslev-Friis, Christina, additional, Mygil, Bjoern, additional, Krebs Albrechtsen, Charlotte, additional, Kavasmaa, Tomi, additional, Mäyrä, Anne, additional, Mennander, Susanna, additional, Rautaneva, Kati, additional, Hiekkanen, Tuula, additional, Kontinen, Vesa, additional, Linden, Kirsti, additional, Toivakka, Sara, additional, Boselli, Emmanuel, additional, Greil, Pierre-Édouard, additional, Mascle, Olivier, additional, Courbon, Aurelie, additional, Lutz, Jean, additional, Simonet, Thérèse, additional, Barbier, Marie, additional, Hlioua, Tarik, additional, Meniolle d’Hauthville, Fleur, additional, Quintin, Christine, additional, Bouattour, Karim, additional, Lecinq, Agnès, additional, Soued, Mickaël, additional, Bonnet, Marie-Pierre, additional, Carbonniere, Mathieu, additional, Fischer, Catherine, additional, Picard, Paola-Carla, additional, Bonnin, Martine, additional, Storme, Brigitte, additional, Bouthors, Anne-Sophie, additional, Detente, Thomas, additional, Nguyen Troung, Minh, additional, Keita, Hawa, additional, Nebout, Sophie, additional, Osse, Lauranne, additional, Delmas, Anne, additional, Vial, Florence, additional, Kaufner, Lutz, additional, Hoefing, Christoph, additional, Mueller, Stefan, additional, Becke, Karin, additional, Blobner, Manfred, additional, Lewald, Heidrun, additional, Schaller, Stefan Josef, additional, Muggleton, Ellis, additional, Bette, Birgit, additional, Neumann, Claudia, additional, Weber, Stefan, additional, Grünewald, Matthias, additional, Ohnesorge, Henning, additional, Helf, Antonia, additional, Jelting, Yvonne, additional, Kranke, Peter, additional, Welfle, Sabine, additional, Staikou, Chryssoula, additional, Stavrianopoulou, Antonia, additional, Tsaroucha, Athanasia, additional, Kalopita, Konstantina, additional, Loukeri, Anastasia, additional, Valsamidis, Dimitrios, additional, Matsota, Paraskevi, additional, Thorsteinsson, Adalbjörn, additional, Tome, Riad, additional, Eidelman, Leonid A., additional, Davis, Atara, additional, Orbach-Zinger, Sharon, additional, Ioscovich, Alexander, additional, Ramona, Iacob, additional, De Simone, Luigi, additional, Pesetti, Barbara, additional, Brazzi, Luca, additional, Zito, Alessandro, additional, Camorcia, Michela, additional, Della Rocca, Giorgio, additional, Aversano, Marco, additional, Frigo, Maria Grazia, additional, Todde, Cristina, additional, Morina, Qamile, additional, Macas, Andrius, additional, Keraitiene, Grazina, additional, Rimaitis, Kestutis, additional, Borg, Francis, additional, Tua, Carl, additional, Kuijpers-Visser, Agnes Geertje, additional, Schyns-van den Berg, Alexandra, additional, Hollmann, Markus W., additional, Van den Berg, Tijs, additional, Koolen, Eric, additional, Dons, Ilse, additional, van der Knijff, Anouk, additional, van der Marel, Caroline, additional, Ruysschaert, Nele, additional, Pelka, Michal, additional, Pluymakers, Christine, additional, Koopman, Seppe, additional, Teunissen, Aart-Jan, additional, Cornelisse, Dick, additional, van Dasselaar, Nick, additional, Verdouw, Bastiaan, additional, Beenakkers, Ingrid, additional, Dahl, Vegard, additional, Hagen, Robert, additional, Vivaldi, Francesco, additional, Eriksen, John Reidar, additional, Wiszt, Radovan, additional, Aslam Tayyaba, Naz, additional, Ringvold, Else-Marie, additional, Chutkowski, Radosław, additional, Skirecki, Tomasz, additional, Wódarski, Bartłomiej, additional, Faria, Maria Aida, additional, Ferreira, Amélia, additional, Sampaio, Ana Catarina, additional, Ferreira, Irene, additional, Matias, Bernardo, additional, Teixeira, Joana, additional, Araujo, Rita, additional, Cabido, Herminia, additional, Fortuna, Rosario, additional, Lemos, Paulo, additional, Cardoso, Carolina, additional, Moura, Fernando, additional, Pereira, Cristiana, additional, Pereira, Sandra, additional, Tavares, Francisca, additional, Vasconcelos, Pedro, additional, Abecasis, Manuel, additional, Lança, Filipa, additional, Muchacho, Paulo, additional, Ormonde, Lucindo, additional, Guedes-Araujo, Isabel, additional, Pinho-Oliveira, Vitor, additional, Paredes, Paulo, additional, Bentes, Carla, additional, Gouveia, Francisco, additional, Milheiro, Ana, additional, Castanheira, Cláudia, additional, Neves, Miriam, additional, Pacheco, Vânia, additional, Cortez, Mara, additional, Tranquada, Raquel, additional, Tareco, Glória, additional, Furtado, Inês, additional, Pereira, Estela, additional, Marinho, Luísa, additional, Seabra, Manue, additional, Bulasevic, Aleksandra, additional, Kendrisic, Mirjana, additional, Jovanovic, Lidija, additional, Pujić, Borislava, additional, Kutlesic, Marija, additional, Grochova, Monika, additional, Simonova, Jana, additional, Pavlovic, Gordana, additional, Rozman, Ales, additional, Blajic, Iva, additional, Graovac, Dragan, additional, Stopar Pintraic, Tatjana, additional, Chiquito, Teresa, additional, Monedero, Pablo, additional, Carlos-Errea, De Joaquin, additional, Guillén-Casbas, Roque, additional, Veiga-Gil, Leonor, additional, Basso, Morena, additional, Garcia Bartolo, Carolina, additional, Hernandez, Cristian, additional, Ricol, Laura, additional, De Santos, Maroto Pinar, additional, Gràcia Solsona, Josep A., additional, López-Baamonde, Manuel, additional, Magaldi Mendaña, Marta, additional, Plaza Moral, Ana María, additional, Vendrell, Marina, additional, Trillo, Lourdes, additional, Perez Garcia, Anibal Ricardo, additional, Alamillo Salas, Clara, additional, Moret, Enric, additional, Ramió, Laura, additional, Aguilar Sanchez, Jose Luis, additional, Soler Pedrola, Maria, additional, Valldeperas Hernandez, Maria Inmaculada, additional, Aldalur, Gorka, additional, Bárcena, Estíbaliz, additional, Herrera, Julia, additional, Iturri, Fernando, additional, Martínez, Alberto, additional, Martínez, Leire, additional, Serna, Rosa, additional, Gilsanz, Fernando, additional, Guasch Arevalo, Emilia, additional, Iannuccelli, Fabrizio, additional, Latorre, Julieta, additional, Rodriguez Roca, Cristina, additional, Pérez Pardo, Osvaldo Ceferino, additional, Sierra Biddle, Natalia, additional, Suárez Cendaña, Ceferina, additional, Hernández González, Lourdes, additional, Remacha González, Caridad, additional, Sánchez Nuez, Raquel, additional, Anta, Diego, additional, Beleña, Jose M., additional, García-Cuadrado, Carmen, additional, Garcia, Irene, additional, Manrique, Susana, additional, Suarez, Elena, additional, Hein, Anette, additional, Arbman, Elisabet, additional, Hansson, Helena, additional, Tillenius, Monika, additional, Al-Taie, Ruaa, additional, Ledin-Eriksson, Susanne, additional, Lindén-Söndersö, Anja, additional, Rosén, Ola, additional, Austruma, Evija, additional, Gillberg, Lars, additional, Darvish, Bijan, additional, Gupta, Anil, additional, Nordstöm, Johan L., additional, Persson, Jan, additional, Rosenberg, Jan, additional, Brühne, Lars, additional, Forshammar, Johan, additional, Ugarph Edfeldt, Malin, additional, Rolfsson, Håkan, additional, Hellblom, Anna, additional, Levin, Katarina, additional, Rabow, Sofus, additional, Thorlacius, Karin, additional, Bansch, Peter, additional, Robertson (Baeriswyl), Moira, additional, Stamer, Ulrike, additional, Mathivon, Stanislas, additional, Savoldelli, Georges, additional, Auf der Maur, Pia, additional, Filipovic, Miodrag, additional, Dullenkopf, Alexander, additional, Brunner, Maya, additional, Girard, Thierry, additional, Vonlanthen, Claudia, additional, Ozbilgin, Sule, additional, Gunaydin D, Berrin, additional, Corman Dincer, Pelin, additional, and Tas Tuna, Ayca, additional

Published
2020
Full Text
View/download PDF

48. Anterior Nucleus of Thalamus Deep Brain Stimulation: A Clinical-Based Analysis of the Ideal Target in Drug-Resistant Epilepsy.

Author

Costa-Gertrudes, Ricardo, Simão, Diogo, Franco, Ana, Morgado, Carlos, Peralta, Ana Rita, Pimentel, José, Gonçalves-Ferreira, António, Bentes, Carla, and Campos, Alexandre Rainha

Abstract

Introduction: Deep brain stimulation of the anterior nucleus of thalamus (ANT-DBS) is an approved procedure for drug-resistant epilepsy. However, the preferred location inside ANT is not well known. In this study, we investigated the relationship between stereotactical coordinates of stimulated contacts and clinical improvement, in order to define the ideal target for ANT-DBS. Methods: Individual contact's coordinates were obtained in the Montreal Neurological Institute (MNI) 152 space, with the utilization of advanced normalization tools and co-registration of pre- and postoperative MRI and CT images in open-source toolbox lead-DBS with the "Atlas of the Human Thalamus." Each contact's pair was either classified as a responder (≥50% seizure reduction and absence of intolerable adverse effects) or nonresponder, with a minimum follow-up of 11 continuous months of stimulation. Results: A total of 19 contacts' pairs were tested in 14 patients. The responder rate was 9 out of 14 patients (64.3%). In 4 patients, a change in contacts' pairs was needed to achieve this result. A highly encouraging location inside ANT (HELIA) was delimited in MNI space, corresponding to an area in the anterior and inferior portion of the anteroventral (AV) nucleus, medially to the endpoint of the mammillothalamic tract (ANT-mtt junction) (x [3.8; 5.85], y [−2.1; −6.35] and z [6.2; 10.1] in MNI space). Statistically significant difference was observed between responders and nonresponders, in terms of the number of coordinates inside this volume. Seven responders and two nonresponders had at least 5 of 6 coordinates (2 electrodes) inside HELIA (77.8% sensitivity and 80% specificity). In 3 patients, changing to contacts that were better placed inside HELIA changed the status from nonresponder to responder. Conclusions: A relationship between stimulated contacts' coordinates and responder status was observed in drug-resistant epilepsy. The possibility to target different locations inside HELIA may help surpass anatomical variations and eventually obtain increased clinical benefit. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

49. Interrater agreement of classification of photoparoxysmal electroencephalographic response

Author

Beniczky, Sándor, primary, Aurlien, Harald, additional, Franceschetti, Silvana, additional, Martins da Silva, Antonio, additional, Bisulli, Francesca, additional, Bentes, Carla, additional, Canafoglia, Laura, additional, Ferri, Lorenzo, additional, Krýsl, David, additional, Rita Peralta, Ana, additional, Rácz, Attila, additional, Cross, J. Helen, additional, and Arzimanoglou, Alexis, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results