1. Wide-Field Optical Coherence Tomography Imaging Improves Rate of Change Detection in Progressing Glaucomatous Eyes Compared With Standard-Field Imaging
- Author
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Bowd, Christopher, Belghith, Akram, Rezapour, Jasmin, Jonas, Jost B, Hyman, Leslie, Weinreb, Robert N, and Zangwill, Linda M
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Bioengineering ,Neurodegenerative ,Aging ,Clinical Research ,Biomedical Imaging ,Eye Disease and Disorders of Vision ,Neurosciences ,Minority Health ,4.2 Evaluation of markers and technologies ,Eye ,Humans ,Tomography ,Optical Coherence ,Disease Progression ,Female ,Male ,Visual Fields ,Middle Aged ,Retinal Ganglion Cells ,Nerve Fibers ,Optic Disk ,Intraocular Pressure ,Aged ,Glaucoma ,Visual Field Tests ,Adult ,glaucoma ,OCT ,wide-field imaging ,progression ,myopia ,Biological Sciences ,Medical and Health Sciences ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeTo compare rates of retinal nerve fiber layer change over time in healthy, eyes with nonprogressing glaucoma and eyes with progressing glaucoma using single wide-field (SWF) and optic nerve head (ONH) cube scan optical coherence tomography (OCT) images.MethodsForty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were included. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube scans centered on the fovea. Visual field progression was defined as guided progression analysis likely progression and/or a significant (P < 0.01) mean deviation slope of less than -1.0 dB/year. Mixed effects models were used to compare rates of change. Highly myopic eyes were included.ResultsThirty glaucomatous eyes were classified as progressing. In eyes with glaucoma, mean global rate of change was -1.22 µm/year (P < 0.001) using SWF images and -0.83 µm/year (P = 0.003) using ONH cube scans. Rate of change was significantly greater in eyes with progressing glaucoma compared with eyes with nonprogressing glaucoma (-1.51 µm/year vs. -1.24 µm/year; P = 0.002) using SWF images and was similar using ONH cube scans (P = 0.27).ConclusionsIn this cohort that includes eyes with and without high axial myopia, the mean rate of retinal nerve fiber layer thinning measured using SWF images was faster in eyes with progressing glaucoma than in eyes with nonprogressing glaucoma. Wide-field OCT images including the ONH and macula can be effective for monitoring glaucomatous progression in patients with and without high myopia.
- Published
- 2024