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Background: Students are a group particularly high risk of adverse effects from such restrictions introduced within counter transmission the SARS-CoV-2 pandemic. Fear felt of contracting the disease and social isolation can lead to consuming excessive amounts of energy with food, resulting in weight gain and eating disorders. Objective. The aim of the study was analysed selected lifestyle aspects of Polish and Turkish students before and during the COVID-19 pandemic and to determine the existence of differences between the lifestyles of these individuals during the two periods. Material and methods. The study was conducted at the turn of 2020-2021 among 435 students, including 331 Polish and 104 Turkish students: The research instrument was an original questionnaire created in a Google Forms, consisting of metric and a proper part regarding lifestyle before and during the pandemic. Prior to the actual study, in order to verify whether the research tool is understandable, a pilot study was conducted, which included 40 individuals. The Wilcoxon test was used to examine the differences between the lifestyle of students before and during the pandemic. A value of p

Cardiovascular diseases accompanying metabolic syndrome comprise one of the leading causes of death worldwide. The medical community undertakes attempts to improve treatment options and minimize cardiovascular diseases’ numerous consequences and exacerbations. In parallel with pharmacotherapies provided by physicians, nutritionists are developing strategies for diet therapy and prevention based on lifestyle changes, with high success rates. Consumption of specified food compounds included in various products with proven protective properties can be helpful in this regard. Due to the wide possibilities of diet in metabolic health promotion, it seems necessary to systematize information about the metabolically protective and cardioprotective properties of fiber, probiotic bacteria, plant sterols, folic acid, vitamins B12, C, and E, PUFAs, lycopene, polyphenols, arginine, CoQ10, and allicin. The aim of this review was to present the food compounds with potential use in cardiometabolic prevention and diet therapy based on the latest available literature.

Background. A properly balanced diet should provide multiple valuable nutrients necessary for the proper functioning of the body through the proper frequency of consuming food products that are their source. This is particularly important during the pandemic when there is a need to support the immune system. Objective. The aim of the study was to assess the frequency of consumption of selected groups of food products and to determine whether this frequency differs among medical and non-medical students in the period before and during the COVID-19 pandemic. Material and methods. The study was conducted among 435 Polish and Turkish students using an original questionnaire. The proper study was preceded by a pilot study in 40 participants.The Wilcoxon test was used to assess the differences in the frequency of consumption of selected groups of products among medical and non-medical students both during and before the pandemic. A value of p

Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver and body composition have not yet been comprehensively analyzed in the context of lifestyle. This study aimed to assess the selected lifestyle factors and quality of life in the context of the development of NAFL (non-alcoholic fatty liver) in women diagnosed with hypothyroidism. This study included 134 women categorized into three groups: with hypothyroidism and NAFL, with only hypothyroidism, and with only NAFL. We compared the groups concerning the KomPAN and WHOQOL-BREF questionnaires, anthropometric measurements, body composition parameters, and the stage of liver steatosis. The individuals with NAFL most frequently consumed lard, fried dishes, processed meats, red meat, sweets, and sweetened beverages. The individuals with hypothyroidism without coexisting NAFL exhibited the highest satisfaction with health. The NAFL group had the highest average body fat percentage. Selected lifestyle aspects influenced the development of NAFL in women diagnosed with hypothyroidism. Women’s overall quality of life did not vary depending on the coexisting medical conditions. Preventive programs should promote the following: the regular consumption of meals, the appropriate energy supply, physical activity, mental health support, and striving for proper body composition parameters.

The lifestyle causes of metabolic disorders in patients with hypothyroidism should be investigated. We aimed to assess the lifestyle and quality of life of women diagnosed with hypothyroidism and search for the presence of differences between the lifestyle and quality of life of women with and without diagnosed lipid metabolism disorders. This study included 311 women. To assess the differences between the groups with and without metabolic disorders, a non-parametric Mann–Whitney U test was performed. Of the products that were potentially beneficial for health, statistically significant differences in the average frequency of consumption were observed for legume seeds (p = 0.014), and of the products potentially unbeneficial for health, the frequencies of consumption of fried dishes (p = 0.016) and fast-food products (p = 0.001) were significant. Only 11.9% rated their free-time physical activity as high. The quality of life was significantly different between the groups. The lifestyle was moderately appropriate. Compared with women with lipid metabolism disorders, women without them exhibited a higher frequency of correct dietary behaviors regarding the consumption of products with a potentially beneficial effect and sleeping duration. Women without lipid metabolism disorders had a better quality of life. Women with hypothyroidism should be educated about the beneficial aspects of the regular consumption of vegetables, fruits, legumes, and fish and sleeping for the optimal amount of time.

Background. Proper nutrition and balanced physical activity have a beneficial effect on the growth and development of young athletes, supporting their endurance and health, which is particularly important in the period of adolescence. Objective. Aim of this study was to assess eating behaviours, frequency of consumption of some food products and selected elements of lifestyle among young dancers, as well as to compare the age of the dancers and the assessed behavior. Material and methods. The study included 198 dancers aged 10-15 years. An originally developed questionnaire was used as a research tool. Results. The largest group of dancers (43%) spent on training up to 2 hours per week. The recommended 4-5 meals/day were consumed by 61.1% of dancers, with 87.4% of respondents having breakfast on a daily basis. The recommendations on the daily intake of several portions of fruit and vegetables were followed by 49% and 36.9% of dancers, respectively. It is observed, that the consumption rates of sweets increased, while the consumption rates of fruit decreased with dancers’age. The consumption rates of packed lunch and afternoon snack increased, whereas the consumption rates of dinner decreased with an increasing number of hours spent training. Conclusions. Eating behaviours and the frequency of consumption of food products by young dancers can be described as varied. Their diet is characterised by regular consumption of meals and a correct frequency of consumption of most food products, including high intake of fruit and vegetables, yoghurt and kefir, as well as low consumption of fast food products. The selected elements of dancers’ lifestyle, such as sleep time and physical activity, are mostly correct.

Broad availability and cost-effectiveness of 99Mo/99mTc generators worldwide support the use, and thus the development, of novel 99mTc-labelled radiopharmaceuticals. In recent years, preclinical and clinical developments for neuroendocrine neoplasms patient management focused on somatostatin receptor subtype 2 (SST2) antagonists, mainly due to their superiority in SST2-tumour targeting and improved diagnostic sensitivity over agonists. The goal of this work was to provide a reliable method for facile preparation of a 99mTc-labelled SST2 antagonist, [99mTc]Tc-TECANT-1, in a hospital radiopharmacy setting, suitable for a multi-centre clinical trial. To ensure successful and reproducible on-site preparation of the radiopharmaceutical for human use shortly before administration, a freeze-dried three-vial kit was developed. The final composition of the kit was established based on the radiolabelling results obtained during the optimisation process, in which variables such as precursor content, pH and buffer, as well as kit formulations, were tested. Finally, the prepared GMP-grade batches met all predefined specification parameters together with long-term kit stability and stability of the product [99mTc]Tc-TECANT-1. Furthermore, the selected precursor content complies with micro-dosing, based on an extended single-dose toxicity study, where histopathology NOEL was established at 0.5 mg/kg BW, being more than 1000 times higher than the planned human dose of 20 µg. In conclusion, [99mTc]Tc-TECANT-1 is suitable to be advanced into a first-in-human clinical trial.

Background. Eating habits are mainly shaped at the first stages of human life. Incorrect eating habits in young individuals may in the future lead to eating disorders and predispose to abnormal body weight. Objective. The aim of the study was to investigate eating habits among adolescents and verify whether there are any differences in eating habits between girls and boys. Material and methods. The study was conducted among 337 post-primary school students, including 126 girls and 211 boys. A standardised questionnaire "My eating habits" was used as a research tool. Results. Secret snacking was slightly more common among girls (27.78%) than boys (24.17%). It was also girls who mostly admitted that other people comment on their diet, as indicated by 33.33% of girls and 18.96% of boys. Girls are also more likely to be dissatisfied with their body weight (41.27% vs. 27.49%) and to occasionally avoid eating despite feeling hungry (42.06% vs. 27.01%) compared to boys. Conclusions. The eating habits of young people are mostly varied. There are differences in the d ietary habits of girls and boys; girls are more likely than boys to overeat under the influence of emotions and to apply dietary restrictions to themselves. In order to promote healthy eating habits and support the mental well-being of young people, it is recommended to provide nutritional education and to implement psychological support for those in need.

Background. Lifestyle encompasses, among other things, eating habits, physical activity, and the use of stimulants. Individual choices in this area have a direct impact on human health. Objective. The aim of this study was to assess the lifestyle in adolescents and to verify whether there is a relationship between selected lifestyle elements and gender. Materials and methods. A total of 304 students (160 women and 144 men) were included in the study. The study used an original questionnaire. Chi-square test was used to assess the correlations between gender and eating habits, physical activity and the use of stimulants among adolescents. A p-value Results. The students surveyed usually have 4-5 meals daily at 3-4-hour intervals (50.33% and 53.8%, respectively). They consume confectionery up to several times a week (35.2%), as declared by more women than men (41.9% of women and 27.8% of men). Adolescents usually practise physical exercise several times a week (36.51%), as reported by 29.38% of women and 44.44% of men. Occasional alcohol consumption was reported by 44.38% of women and 42.4% of men. A total of 61.92% of respondents were non-smokers, as declared by more women than men. Conclusions. The majority of adolescents lead an unhealthy lifestyle in terms of eating habits, alcohol consumption and smoking. Positive behaviours were observed for physical activity. Some lifestyle elements were correlated with gender. Women devote less time to physical activity compared to men. Men have a higher tendency to consume carbonated beverages and higher amounts of alcohol than women. The obtained research results indicate the need for health education.

Despite significant advances in nuclear medicine for diagnosing and treating prostate cancer (PCa), research into new ligands with increasingly better biological properties is still ongoing. Prostate-specific membrane antigen (PSMA) ligands show great potential as radioisotope carriers for the diagnosis and therapy of patients with metastatic PCa. PSMA is expressed in most types of prostate cancer, and its expression is increased in poorly differentiated, metastatic, and hormone-refractory cancers; therefore, it may be a valuable target for the development of radiopharmaceuticals and radioligands, such as urea PSMA inhibitors, for the precise diagnosis, staging, and treatment of prostate cancer. Four developed PSMA-HYNIC inhibitors for technetium-99m labeling and subsequent diagnosis were subjected to preclinical in vitro and in vivo studies to evaluate and compare their diagnostic properties. Among the studied compounds, the PSMA-T4 (Glu-CO-Lys-L-Trp-4-Amc-HYNIC) inhibitor showed the best biological properties for the diagnosis of PCa metastases. [99mTc]Tc-PSMA-T4 also showed effectiveness in single-photon emission computed tomography (SPECT) studies in humans, and soon, its usefulness will be extensively evaluated in phase 2/3 clinical trials.

The development of cardiovascular diseases is undoubtedly influenced by improper dietary behavior. The most common mistakes include irregularity of meal consumption, high dietary atherogenicity: snacking on sweets between meals, low supply of dietary fiber, unsaturated fatty acids, legume seeds, and high supply of meat and meat products. Among many food components, some are characterized by a specific cardioprotective effect, which means that their supply of food may prevent the occurrence of cardiovascular disease or improve the health of the sick. Coenzyme Q10 (CoQ10) is one of the ingredients showing cardioprotective effects on the heart and blood vessels. Antioxidant and lipid profile-enhancing effects are also attributed to sitosterol which is one of the plant-derived sterols. A very important argument indicating the necessity of a varied diet rich in a variety of plant products is the beneficial effect of polyphenols, which are most abundant in multicolored vegetables and fruits. Numerous studies show their effectiveness in lowering blood pressure, improving lipid profile, and regeneration of vascular endothelium. The collected publications from the field of lifestyle medicine can be a source of knowledge for dieticians, physicians, and people associated with physical culture and human mental health to prevent the development of cardiovascular diseases and reduce the risk of death from this cause.

Numerous different molecules of prostate-specific membrane antigen (PSMA) ligands are used to detect prostate cancer (PCa); most approaches utilize gallium PET and a few reports describe the role of SPECT/CT. [99mTc]Tc-PSMA-T4 is a new radiopharmaceutical designed for the diagnosis of patients with PCa. We conducted a single site, prospective, preliminary case series study that included 31 patients with PCa; all had undergone clinical, biochemical or imaging examination and exhibited clear or suspicious active disease or clinical/biochemical recurrence of PCa. Whole-body (WB) SPECT/CT after i.v. administration of [99mTc]Tc-PSMA-T4 was utilized; acquisition images were obtained at three time points. The clinical value of the images was assessed in regard to the evaluation of tumor extent in patients with confirmed PC that qualified for initial therapy and the evaluation of tumor recurrence; both provided encouraging results. The late acquisition of WB-SPECT resulted in better lesions delineation. The results of the analysis of the sensitivity/specificity were: 92%/100% in cases of primary cancer, 83%/100% in terms of pelvic lymph nodes disease, 100%/95% in other lymph nodes and soft tissue involvement, respectively, and bone mets were both 100%. An oncotropic SPECT [99mTc]Tc-PSMA-T4 can help in selecting a rational therapeutic strategy for a patient with an initial diagnosis of PCa by assessing the extent of cancer and also after complex radical or palliative therapy in case of biochemical recurrence for re-staging.

The aim of this study was to assess the utility of [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 scintigraphy in the management of patients with hypoglycemia, particularly in the detection of occult insulinoma.Forty patients with hypoglycemia and increased/confusing results of serum insulin and C-peptide concentration and negative/inconclusive results of other imaging examinations were enrolled in the study. In all patients GLP-1 receptor imaging was performed to localise potential pancreatic lesions.Positive results of GLP-1 scintigraphy were observed in 28 patients. In 18 patients postsurgical histopathological examination confirmed diagnosis of insulinoma. Two patients had contraindications to the surgery, one patient did not want to be operated. One patient, who presented with postprandial hypoglycemia, with positive result of GLP-1 imaging was not qualified for surgery and is in the observational group. Eight patients were lost for follow up, among them 6 patients with positive GLP-1 scintigraphy result. One patient with negative scintigraphy was diagnosed with malignant insulinoma. In two patients with negative scintigraphy Munchausen syndrome was diagnosed (patients were taking insulin). Other seven patients with negative results of 99mTcGLP-1 scintigraphy and postprandial hypoglycemia with C-peptide and insulin levels within the limits of normal ranges are in the observational group. We would like to mention that 99mTc-GLP1-SPECT/CT was also performed in 3 pts with nesidioblastosis (revealing diffuse tracer uptake in two and a focal lesion in one case) and in two patients with malignant insulinoma (with the a focal uptake in the localization of a removed pancreatic headin one case and negative GLP-1 1 scintigraphy in the other patient).99mTc-GLP1-SPECT/CT could be helpful examination in the management of patients with hypoglycemia enabling proper localization of the pancreatic lesion and effective surgical treatment. This imaging technique may eliminate the need to perform invasive procedures in case of occult insulinoma.