7 results on '"BAAR"'
Search Results
2. Reports from Biogen Inc. Add New Data to Findings in Relapsing-Remitting Multiple Sclerosis (Diroximel Fumarate In Patients With Relapsing-remitting Multiple Sclerosis: Neda-3 After Re-baselining In the Phase 3 Evolve-ms-1 Study).
- Subjects
MULTIPLE sclerosis ,DISEASE relapse ,NEUROLOGICAL disorders ,AUTOIMMUNE diseases ,DEMYELINATION ,DICARBOXYLIC acids - Abstract
A recent study conducted by Biogen Inc. evaluated the safety, tolerability, and efficacy of diroximel fumarate (DRF) in patients with relapsing-remitting multiple sclerosis (MS). The study used a composite efficacy endpoint called No Evidence of Disease Activity (NEDA-3), which includes criteria such as no relapse, no disability progression, and no new lesions. The results showed that approximately half of the DRF-treated patients achieved NEDA-3 at week 96 after re-baselining, compared to 36.5% of patients who were not re-baselined. Re-baselining may be a useful approach to assess the efficacy of disease-modifying therapies for MS. [Extracted from the article]
- Published
- 2024
3. Findings on Biotechnology Detailed by Investigators at Biogen (A Retrospective Analysis of the Potential Impact of Differences In Aggregates On Clinical Immunogenicity of Biosimilars and Their Reference Products).
- Subjects
IMMUNE response ,BIOTECHNOLOGY ,BIOSIMILARS ,RETROSPECTIVE studies ,BIOTECHNOLOGY industries - Abstract
A study conducted by Biogen investigated the potential impact of differences in aggregates on the clinical immunogenicity of biosimilars and their reference products. The study found that there were limited differences in the content of high molecular weight species (HMWs) between marketed biosimilars and reference monoclonal antibodies (mAbs). These differences were not associated with differences in reported immunogenicity, as measured by the incidence of antidrug-antibodies (ADAs) and neutralizing ADAs in comparative clinical studies. The study suggests that HMWs may not have a significant impact on the immunogenicity of biosimilars. [Extracted from the article]
- Published
- 2024
4. thinkQ2 AG Reports Findings in Clinical Trials and Studies (Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults).
- Subjects
CHOLESTEROL hydroxylase ,ANTICHOLESTEREMIC agents ,PHARMACOKINETICS ,ENZYMES ,ADULTS - Published
- 2023
5. Mycobacterium SPP como endosimbionte de amebas de vida libre en aguas de CÚCUTA, 2018-2019
- Author
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Gomez Garcia, Esteicy Dayanna. and Ramirez Rozo, Maria-Fernanda.
- Subjects
Free-living amoebas ,Amebas de vida libre ,Endosymbiosis ,Endosimbiosis ,Filtración por membrana ,BAAR ,Membrane filtration - Abstract
117 p., Free-living amoebas have been isolated from habitats in common with mycobacteria including cold water for consumption, hot water systems in hospitals, contact lenses, among other habitats. The purpose of this study is to test the endosymbiotic relationship between free-living amoebas and Mycobacterium spp. Objective: Determining endosymbiosis of Mycobacterium spp in free-living amoebas in water samples from Cúcuta, 2019.Methods:The techniques used were membrane filtration and planting in nutritious agar for AVL isolation, lysis and Zielh-Neelsen coloration for the detection of BAAR and confirmation of the presence of these by planting in Ogawa Kudoh agar. Results: the high presence of free-living amoebas in the three samplings in all types of water (49%), indicating that both consumer water, rivers, swimming pool and residuals can possess such microorganisms. there is an endosymbiosis of Mycobacterium spp and aVLs of 30% of the collected samples, confirmed in Zielh Neelsen tying and microbiological culture compatible with Resistant Alcohol Acid Bacillus., Las amebas de vida libre (AVL) han sido aisladas de hábitats en común con las micobacterias incluyendo agua fría para el consumo, sistemas de agua caliente en hospitales, lentes de contacto, entre otros hábitats; El propósito de este estudio se basa en probar la relación endosimbiótica entre las amebas de vida libre y Mycobacterium spp. Objetivo: Determinar la endosimbiosis de Mycobacterium spp en amebas de vida libre en muestras de agua de Cúcuta, 2019. Métodos: Las técnicas empleadas fueron filtración por membrana y siembra en agar nutritivo para el aislamiento de AVL, lisis y coloración de Zielh-Neelsen para la detección de BAAR y confirmación de la presencia de éstos por siembra en agar Ogawa Kudoh Resultados: se demuestra la alta presencia de amebas de vida libre en los tres muestreos realizados en aguas de todo tipo (49%), lo cual indica que tanto aguas de consumo, ríos, piscina como residuales pueden poseer este tipo de microorganismos. Existe una endosimbiosis de Mycobacterium spp y las AVL en un 30% de las muestras recolectadas, confirmada en la tinción de Zielh Neelsen y cultivo microbiológico compatibles con Bacilos Acido Alcohol Resistentes., Pregrado, Bacteriólogo(a) y Laboratorista Clínico, INTRODUCCIÓN ................................................................................................... 23 1. PROBLEMA ....................................................................................................... 25 1.1 PLANTEAMIENTO DE PROBLEMA ................................................................ 25 1.2 FORMULACION DEL PROBLEMA .................................................................. 28 1.3 OBJETIVOS ..................................................................................................... 28 1.3.1 Objetivo General ........................................................................................... 28 1.3.2 Objetivos Específicos .................................................................................... 28 1.4. JUSTIFICACIÓN ............................................................................................. 28 2. MARCO REFERENCIAL.................................................................................... 30 2.1 ANTECEDENTES ............................................................................................ 30 2.2 MARCO TEÓRICO .......................................................................................... 34 2.2.1 EL AGUA ...................................................................................................... 34 2.2.2 Amebas de vida libre .................................................................................... 34 2.2.2 Mycobacterium spp ....................................................................................... 45 2.2.3. Endosimbiosis bacteriana ........................................................................... 54 2.3 MARCO CONCEPTUAL .................................................................................. 56 2.4 Marco legal ...................................................................................................... 56 2.5 MARCO CONTEXTUAL .................................................................................. 58 2.6 SISTEMA DE HIPÓTESIS ............................................................................... 59 2.7 MATRIZ OPERATIVA DE LAS VARIABLES .................................................... 60 3. MARCO METODOLÓGICO ............................................................................... 61 18 3.1 TIPO DE INVESTIGACIÓN: ............................................................................. 61 3.1.1 Nivel de la Investigación: .............................................................................. 61 3.1.2 Diseño de la Investigación: ........................................................................... 61 3.2 MATERIALES Y MÉTODOS ............................................................................ 61 3.2.1 Fase I preparatoria: ....................................................................................... 61 3.2.2 Fase II descriptiva: ........................................................................................ 62 3.2.3 Fase III interactiva: ........................................................................................ 62 3.2.4 Fase IV analítica: .......................................................................................... 62 3.2.5 Fase de cierre: .............................................................................................. 63 3.3 POBLACIÓN Y MUESTRA .............................................................................. 63 3.3.1 Población. ..................................................................................................... 63 3.3.2 Muestra. ........................................................................................................ 63 3.4 TÉCNICA E INSTRUMENTOS DE RECOLECCIÓN DE DATOS .................... 64 3.5 TÉCNICA DE PROCESAMIENTO Y ANÁLISIS DE DATOS ........................... 64 4. ANÁLISIS E INTERPRETACIÓN DE RESULTADOS ........................................ 65 4.1 RESULTADOS E INTERPRETACIÓN ............................................................. 65 4.1.1 Aislamiento de Amebas de Vida libre de los diferentes tipos de agua de Cúcuta Norte de Santander ................................................................................... 65 4.1.2 Bacilos Acido Alcohol resistentes en el interior de las amebas de vida libre 71 4.2 Discusión ......................................................................................................... 72 5. CONCLUSIONES Y RECOMENDACIONES ..................................................... 76 5.1 CONCLUSIONES ............................................................................................ 76 5.2 RECOMENDACIONES .................................................................................... 76 BIBLIOGRAFIA ...................................................................................................... 78 ANEXOS ................................................................................................................ 85, Ej. 1
- Published
- 2019
6. Linfadenite granulomatosa em suínos no Brasil : caracterização histopatológica e micobactérias identificadas
- Author
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Mori, Ana Paula, Driemeier, David, and Kich, Jalusa Deon
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Granuloma ,In situ hibridization ,Brasil ,Suínos [Linfadenite granulomatosa] ,BAAR ,Técnicas e procedimentos diagnósticos ,Diagnostic methods ,Mycobacterium sp ,Swine tuberculosis - Abstract
Entre os anos 2012 e 2014, a linfadenite granulomatosa (LG) em suínos representou 99% de todas as lesões associadas a zoonoses nos frigoríficos brasileiros. O Mycobacterium avium hominissuis (MAH) é a principal subespécie das micobactérias associada à LG em suínos, com raros casos atribuídos as micobactérias do Complexo Mycobacterium tuberculosis. As lesões macroscópicas, histopatológicas e técnica de Ziehl-Neelsen (ZN) não definem a espécie de micobactéria envolvida na LG. O padrão ouro de diagnóstico é o isolamento de micobactérias, seguido de técnicas moleculares. Este estudo teve como objetivo pesquisar a etiologia da LG no Brasil para atualizar os dados nacionais, e padronizar a técnica de Hibridização in situ Fluorescente (FISH) em linfonodos parafinizados de suínos com LG. No ano de 2017 o Serviço de Inspeção Federal (SIF) coletou em 19 frigoríficos, 637 linfonodos de suínos com lesões granulomatosas, com origem em oito estados brasileiros. As amostras foram submetidas a exame histopatológico, técnica histoquímica de ZN, isolamento de micobactérias, Reação em Cadeia da Polimerase (PCR) e FISH. De acordo com o conhecimento dos autores esta é a primeira tentativa descrita na literatura de padronização da técnica de FISH em tecidos parafinizados de suínos. A lesão histopatológica granulomatosa foi observada em 85,1% dos tecidos linfoides. A taxa de isolamento de micobactérias foi de 32,08% (128/399), destas 76,56% (98/128) origens foram positivas para MAH, 1,56% (2/128) origens positivas para Mycobacterium bovis (M. bovis), 21,87% (28/128) origens positivas e 10 origens negativas para o gênero Mycobacterium spp. Observou-se bacilos-álcool ácido resistentes (BAAR) em 71,7% das amostras de MAH, em 75% das amostras de Mycobacterium spp., e em uma amostra (1/3) M. bovis. Das amostras positivas para BAAR no tecido, 60,47% não isolaram ou foram negativas na técnica da PCR para Mycobacterium spp. A FISH não apresentou resultados positivos em linfonodo parafinizado de suínos. O MAH foi à subespécie mais diagnosticada na LG em suínos do Brasil, com apenas duas origens positivas para M. bovis. Os resultados obtidos neste estudo ficam a disposição para analises de risco, para subsidiar políticas públicas relacionadas à inspeção assim como programas de vigilância de tuberculose suína. Granulomatous lymphadenitis (GL) in pigs represents 99% of all lesions associated with zoonoses in Brazilian slaughterhouses between 2012 and 2014. Mycobacterium avium hominissuis (MAH) is the main subspecies of mycobacteria associated with GL in pigs, and few cases are attributed to the Complex Mycobacterium tuberculosis. The macroscopic, histopathological and Ziehl-Neelsen (ZN) lesions do not define the mycobacterial species involved in GL. The isolation of mycobacteria is the gold standard for diagnosis. Molecular techniques are also used for subspecie determination. The aim of this study was to investigate the etiology of granulomatous lesions for the validation of national data regarding this lesion in pigs and to standardize a fluorescence in situ hybridization (FISH) test in formalin-fixed lymph nodes with granulomatous lesions. In 2017, federal veterinary meat inspectors collected 637 mesenteric lymph nodes with granulomatous lesions from 19 slaughterhouses. Granulomatous histopathological lesions were observed in 85.1% of the lymphoid tissues. The isolation rate of mycobacteria was 32.08%, of these isolates 76.56% were MAH positive, 1.56% for Mycobacterium bovis (M. bovis) and 21,87% for Mycobacterium spp. Acid-alcohol resistant bacillus (BAAR) was observed in 71.7% of the MAH samples, in 75% of the samples of Mycobacterium spp, and in one sample of M. bovis. The standardization of the FISH technique in formalin-fixed porcine lymph nodes was unsuccessful. MAH was the most diagnosed subspecies involved in GL in pigs, with only two positive for M. bovis. The results of this study are available for risk analysis to support inspection-related public policies as well as swine tuberculosis surveillance programs.
- Published
- 2019
7. PREVALÊNCIA DE TUBERCULOSE NO HOSPITAL DAS CLÍNICAS DA UNIVERSIDADE FEDERAL DE GÓIAS.
- Author
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DA SILVA, JEFFERNSON VINÍCIUS, SIQUEIRA DAMACENO, NÚBIA, and DE ABREU BATISTA, LINDON JONHSON
- Published
- 2016
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