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164 results on '"Ayyoub, Maha"'

1. Abstract A076: T-cell exhaustion is an independent predictive biomarker of clinical outcome in high grade serous ovarian cancer regardless of homologous recombination deficiency status

Author

Salvioni, Anna, primary, Del, Mathilde, additional, Michelas, Marie, additional, Vuattoux, Pierre, additional, Scarlata, Clara-Maria, additional, Martinez-Gomez, Carlos, additional, Van Acker, Nathalie, additional, Frenois, François-Xavier, additional, Bataillon, Guillaume, additional, Delord, Jean-Pierre, additional, Martinez, Alejandra, additional, and Ayyoub, Maha, additional

Published
2024
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3. Consensus nomenclature for CD8+ T cell phenotypes in cancer

Author

Apetoh, Lionel, Smyth, Mark J, Drake, Charles G, Abastado, Jean-Pierre, Apte, Ron N, Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P, Comin-Anduix, Begoña, Coukos, Georges, Dhodapkar, Madhav V, Dranoff, Glenn, Frazer, Ian H, Fridman, Wolf-Hervé, Gabrilovich, Dmitry I, Gilboa, Eli, Gnjatic, Sacha, Jäger, Dirk, Kalinski, Pawel, Kaufman, Howard L, Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T, Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J, Mempel, Thorsten R, Mittendorf, Elizabeth A, Odun, Kunle, Overwijk, Willem W, Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D, Schuler, Gerold, Srivastava, Pramod K, Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H, van der Bruggen, Pierre, van den Eynde, Benoît J, Wang, Ena, Zou, Weiping, Whiteside, Theresa L, Speiser, Daniel E, Pardoll, Drew M, Restifo, Nicholas P, and Anderson, Ana C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, 2.1 Biological and endogenous factors, Aetiology, anergy, anticancer immunity, CD8(+) T cells, cytotoxicity, exhaustion, effector, IFN gamma, senescence, stemness, CD8+ T cells, IFNγ, Oncology and carcinogenesis
Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.

Published
2015

4. Immune changes in hilar tumor draining lymph nodes following node sparing neoadjuvant chemoradiotherapy of localized cN0 non-small cell lung cancer

Author

Khalifa, Jonathan, primary, Thébault, Noémie, additional, Scarlata, Clara-Maria, additional, Norkowski, Emma, additional, Massabeau, Carole, additional, Brouchet, Laurent, additional, Peries Bataille, Sophie, additional, Casaroli, Christelle, additional, Vaz, Liza, additional, Valle, Carine, additional, Sarot, Emeline, additional, Saint-Laurent, Nathalie, additional, Martin, Etienne, additional, Pages, Pierre-Benoît, additional, Millière, Alice, additional, Mazières, Julien, additional, Cohen-Jonathan Moyal, Elizabeth, additional, Lauzéral-Vizcaïno, Françoise, additional, and Ayyoub, Maha, additional

Published
2023
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5. Data from Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

Author

Balança, Camille-Charlotte, primary, Scarlata, Clara-Maria, primary, Michelas, Marie, primary, Devaud, Christel, primary, Sarradin, Victor, primary, Franchet, Camille, primary, Martinez Gomez, Carlos, primary, Gomez-Roca, Carlos, primary, Tosolini, Marie, primary, Heaugwane, Diana, primary, Lauzéral-Vizcaino, Françoise, primary, Mir-Mesnier, Lucile, primary, Féliu, Virginie, primary, Valle, Carine, primary, Pont, Frédéric, primary, Ferron, Gwénaël, primary, Gladieff, Laurence, primary, Motton, Stéphanie, primary, Tanguy Le Gac, Yann, primary, Dupret-Bories, Agnès, primary, Sarini, Jérôme, primary, Vairel, Benjamin, primary, Illac, Claire, primary, Siegfried-Vergnon, Aurore, primary, Mery, Eliane, primary, Fournié, Jean-Jacques, primary, Vergez, Sébastien, primary, Delord, Jean-Pierre, primary, Rochaix, Philippe, primary, Martinez, Alejandra, primary, and Ayyoub, Maha, primary

Published
2023
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6. Supplementary Figures and Tables from Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

Author

Balança, Camille-Charlotte, primary, Scarlata, Clara-Maria, primary, Michelas, Marie, primary, Devaud, Christel, primary, Sarradin, Victor, primary, Franchet, Camille, primary, Martinez Gomez, Carlos, primary, Gomez-Roca, Carlos, primary, Tosolini, Marie, primary, Heaugwane, Diana, primary, Lauzéral-Vizcaino, Françoise, primary, Mir-Mesnier, Lucile, primary, Féliu, Virginie, primary, Valle, Carine, primary, Pont, Frédéric, primary, Ferron, Gwénaël, primary, Gladieff, Laurence, primary, Motton, Stéphanie, primary, Tanguy Le Gac, Yann, primary, Dupret-Bories, Agnès, primary, Sarini, Jérôme, primary, Vairel, Benjamin, primary, Illac, Claire, primary, Siegfried-Vergnon, Aurore, primary, Mery, Eliane, primary, Fournié, Jean-Jacques, primary, Vergez, Sébastien, primary, Delord, Jean-Pierre, primary, Rochaix, Philippe, primary, Martinez, Alejandra, primary, and Ayyoub, Maha, primary

Published
2023
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12. Supplementary Figure 1 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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13. Supplementary Methods from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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14. Supplementary Figure 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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15. Supplementary Table 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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17. Supplementary Figure Legend from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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18. Supplementary Table 2 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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19. Data from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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20. Supplementary Figure Legend from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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21. Supplementary Figure 5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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22. Supplementary Figure 3 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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23. Data from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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28. Supplementary Figure 4 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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29. Supplementary Figure 6 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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30. Supplementary Figure 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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31. Supplementary Figure 5 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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32. Supplementary Table 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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34. Supplementary Figure 4 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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35. Supplementary Figure 2 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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37. Supplementary Figure 2 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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38. Supplementary Figure 3 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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40. Supplementary Materials, Legends for Figures 1-5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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43. Distant antimetastatic effect of enterotropic colon cancer–derived α4β7+CD8+ T cells.

Author

Feliu, Virginie, Gomez-Roca, Carlos, Michelas, Marie, Thébault, Noémie, Lauzéral-Vizcaino, Françoise, Salvioni, Anna, Scandella, Lise, Sarot, Emeline, Valle, Carine, Balança, Camille-Charlotte, Scarlata, Clara-Maria, Delord, Jean-Pierre, Ayyoub, Maha, and Devaud, Christel

Abstract

Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, we show, in metastatic CRC preclinical models, that orthotopically implanted primary colon tumors exert a colon-specific antimetastatic effect on distant hepatic lesions. Enterotropic α4β7 integrin–expressing neoantigen-specific CD8 T cells were key components of the antimetastatic effect. Accordingly, the presence of concomitant colon tumors improved control of liver lesions by anti–PD-L1 proof-of-concept immunotherapy and generated protective immune memory, whereas partial depletion of α4β7+ cells abrogated control of metastases. Last, in patients with metastatic CRC, response to ICB was associated with expression of α4β7 integrin in metastases and with circulating α4β7+ CD8 T cells. Our findings identify a systemic cancer immunosurveillance role for gut-primed tumor-specific α4β7+ CD8 T cells. Editor's summary: In patients with metastatic colorectal carcinoma (CRC), immune checkpoint blockade (ICB) therapies have historically had a poor success rate. Using a mouse CRC model featuring orthotopic implantation of tumors in the colon, Feliu et al. found that a subset of these colonic tumors could stimulate the differentiation of CD8+ T cells capable of spontaneously controlling growth of the primary tumor and a concomitant tumor implanted in the liver to model metastatic disease. The critical CD8+ effector cells supporting control of metastatic deposits expressed the gut-homing α4β7 integrin receptor. These findings combined with analysis of T cells from patients with metastatic CRC point to gut-primed α4β7+ T cells as key antitumor effectors that can also mediate systemic immunosurveillance providing immune control of metastatic disease. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2023
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45. Circulating Exhausted PD-1+CD39+ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade

Author

Martinez-Gomez, Carlos, primary, Michelas, Marie, additional, Scarlata, Clara-Maria, additional, Salvioni, Anna, additional, Gomez-Roca, Carlos, additional, Sarradin, Victor, additional, Lauzéral-Vizcaino, Françoise, additional, Féliu, Virginie, additional, Dupret-Bories, Agnès, additional, Ferron, Gwénaël, additional, Sarini, Jérôme, additional, Devaud, Christel, additional, Delord, Jean-Pierre, additional, Balança, Camille-Charlotte, additional, Martinez, Alejandra, additional, and Ayyoub, Maha, additional

Published
2022
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46. Abstract 3203: Cutting edge biomarkers strategy to provide early insights into activity of EVT-801, a novel selective VEGFR-3 inhibitor that targets tumor angiogenesis during the FIH clinical trial

Author

Paillasse, Michael R., primary, Garner, James, additional, Fitzgerald, Michael, additional, Davenne, Lise, additional, Ancey, Pierre-Benoit, additional, Poussereau-Pomie, celine, additional, Esquerre, Michael, additional, Badet, Gaelle, additional, Tuyaret, Joel, additional, Mandron, Marie, additional, Rochaix, Philippe, additional, Ayyoub, Maha, additional, Scarlata, Clara Maria, additional, Ménétrier-Caux, Christine, additional, CAUX, Chrsitophe, additional, Cassier, Philippe, additional, Delord, Jean-Pierre, additional, Roca, Carlos Gomez, additional, and Fons, Pierre, additional

Published
2022
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47. Circulating Exhausted PD-1 + CD39 + Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade.

Author

Martinez-Gomez, Carlos, Michelas, Marie, Scarlata, Clara-Maria, Salvioni, Anna, Gomez-Roca, Carlos, Sarradin, Victor, Lauzéral-Vizcaino, Françoise, Féliu, Virginie, Dupret-Bories, Agnès, Ferron, Gwénaël, Sarini, Jérôme, Devaud, Christel, Delord, Jean-Pierre, Balança, Camille-Charlotte, Martinez, Alejandra, and Ayyoub, Maha

Subjects
PROGRAMMED cell death 1 receptors, CYTOKINES, BIOMARKERS, IMMUNOSUPPRESSION, MANN Whitney U Test, CELL proliferation, DESCRIPTIVE statistics, TUMOR antigens, T cells, DATA analysis software, IMMUNOTHERAPY, PHENOTYPES, BLOOD
Abstract

Simple Summary: Not all cancer patients receiving immunotherapy by immune checkpoint blockade experience a clinical benefit. Our study was aimed at identifying biomarkers that could guide the selection of immunotherapy-responsive patients. Immunotherapy targets two major populations of lymphocytes: CD8 T cells, which directly kill tumor cells, and CD4 T cells, which provide help to CD8 T cells, the role of which in clinical responsiveness to immunotherapy has been less explored. We identified, in the blood of cancer patients, a population of CD4 T cells expressing inhibitory receptors targeted by immunotherapy. We showed that these cells were activated and proliferating, indicating their potential involvement in ongoing immune responses. Accordingly, we showed that they were specific for tumor antigens. In a prospective cohort, we showed that high proportions of these cells prior to therapy were associated with a response to immunotherapy. Tumor-infiltrating exhausted PD-1hiCD39+ tumor-antigen (Ag)-specific CD4 T cells contribute to the response to immune checkpoint blockade (ICB), but their circulating counterparts, which could represent accessible biomarkers, have not been assessed. Here, we analyzed circulating PD-1+CD39+ CD4 T cells and show that this population was present at higher proportions in cancer patients than in healthy individuals and was enriched in activated HLA-DR+ and ICOS+ and proliferating KI67+ cells, indicative of their involvement in ongoing immune responses. Among memory CD4 T cells, this population contained the lowest proportions of cells producing effector cytokines, suggesting they were exhausted. In patients with HPV-induced malignancies, the PD-1+CD39+ population contained high proportions of HPV Ag-specific T cells. In patients treated by ICB for HPV-induced tumors, the proportion of circulating PD-1+CD39+ CD4 T cells was predictive of the clinical response. Our results identify CD39 expression as a surrogate marker of circulating helper tumor-Ag-specific CD4 T cells. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer

Author

Martinez, Alejandra, Delord, Jean-Pierre, Ayyoub, Maha, and Devaud, Christel

Subjects
lymphocytes, preclinical mouse models, clinical trials, endocrine system diseases, immune contexture, adaptive and innate immune responses, Review, Epithelial ovarian cancer, immunogenicity, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, female genital diseases and pregnancy complications, myeloid cells, tumor microenvironment, immunotherapy
Abstract

In the past 20 years, the immune system has increasingly been recognized as a major player in tumor cell control, leading to considerable advances in cancer treatment. While promising with regards to melanoma, renal cancer and non-small cell lung cancer, immunotherapy provides, for the time being, limited success in other cancers, including ovarian cancer, potentially due to insufficient immunogenicity or to a particularly immunosuppressive microenvironment. In this review, we provide a global description of the immune context of ovarian cancer, in particular epithelial ovarian cancer (EOC). We describe the adaptive and innate components involved in the EOC immune response, including infiltrating tumor-specific T lymphocytes, B lymphocytes, and natural killer and myeloid cells. In addition, we highlight the rationale behind the use of EOC preclinical mouse models to assess resistance to immunotherapy, and we summarize the main preclinical studies that yielded anti-EOC immunotherapeutic strategies. Finally, we focus on major published or ongoing immunotherapy clinical trials concerning EOC.

Published
2020

50. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Author

Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, Zitvogel, Laurence, Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, and Zitvogel, Laurence

Abstract

Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2K(b)-restricted CD8(+) T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.

Published
2020
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