28 results on '"Aydoğdu, Zekiye"'
Search Results
2. The Contribution of Ultrasonographic Characteristics of Mediastinal Lymph Nodes on Differential Diagnosis of Tuberculous Lymphadenitis from Sarcoidosis
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Erol, Serhat, Anar, Ceyda, Erer, Onur Fevzi, Biçmen, Can, and Aydoğdu, Zekiye
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Sarcoidosis ,Endobronchial ultrasonography ,Original Article ,Mediastinal tuberculous lymphadenitis - Abstract
Background: Sarcoidosis and Mediastinal Tuberculous Lymphadenitis (MTLA) are two granulomatous diseases. Differentiation between these two diseases is dependent on clinical presentation, microbiological investigation, and cytopathological examination. In endemic regions, differential diagnosis of MTLA and sarcoidosis might be difficult. Endobronchial ultrasound guided Transbronchial Needle Aspiration (EBUS-TBNA) is a new diagnostic procedure for the diagnosis of mediastinal lymphadenopathy. EBUS not only enables the sampling of Lymph Nodes (LN), but also visualization of sonographic features of them. We hypothesized that the sonographic features of LN may help to differentiate MTLA from sarcoidosis. Materials and Methods: This is a retrospective analysis of patients with intrathoracic lymphadenopathy who underwent EBUS-TBNA and were finally diagnosed as sarcoidosis or MTLA. Size, shape, margin, echogenicity, and coagulation necrosis were compared between the groups. Results: A total of 257 LNs (215 sarcoidosis, 42 MTLA) were examined in 101 patients. A heterogeneous echotexture of lymph nodes was significantly more common (P
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- 2018
3. The relation between distant metastasis and genetic change type in stage IV lung adenocarcinoma patients at diagnosis
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Ermin, Sinem, primary, Batum, Özgür, additional, Saka Güvenç, Merve, additional, Diniz, Gülden, additional, Ayrancı, Aysu, additional, Erdoğan, Kadri Murat, additional, Yücel, Nur, additional, Yıldırım, Eylem, additional, Özdemir, Taha Reşid, additional, Hacar, Alev Gülşah, additional, Güldaval, Filiz, additional, Koç, Altuğ, additional, Aydoğdu, Zekiye, additional, Balcı, Günseli, additional, Özyılmaz, Berk, additional, Akşit Yaşar, Hacer, additional, Özer Kaya, Özge, additional, Gayaf, Mine, additional, Kırbıyık, Özgür, additional, Aksel, Nimet, additional, Kutbay, Yaşar Bekir, additional, Ursavaş, Tuba Nihal, additional, Karadeniz, Gülistan, additional, Polat, Gülru, additional, Kömürcüoğlu, Berna, additional, Çırak, Ali Kadri, additional, and Yılmaz, Ufuk, additional
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- 2020
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4. A rare case: castlemanâs disease
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Çelik, Ezgi Çimen, primary, Yağcı, Tarık, additional, Üçvet, Ahmet, additional, Gürsoy, Soner, additional, and Aydoğdu, Zekiye, additional
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- 2020
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5. Nodular Pulmonary Amyloidosis Mimicking Breast Carcinoma Metastasis
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Çelik, Ezgi Çimen, primary, Yazgan, Serkan, additional, Gürsoy, Soner, additional, Ucvet, Ahmet, additional, and Aydoğdu, Zekiye, additional
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- 2020
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6. Prognostic Affect of Predominant Histologic Subtypes in Resected Pulmonary Adenocarcinoma Predominant Subtypes of Pulmonary Adenocarcinoma
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Yaldız, Demet, primary, Örs Kaya, Şeyda, additional, Ceylan, Kenan Can, additional, Acar, Arkın, additional, Aydoğdu, Zekiye, additional, Gürsoy, Soner, additional, and Yaldız, Sadık, additional
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- 2019
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7. The role of bronchoalveolar pattern of the former classification in the 8th edition of iaslc-tnm classification
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Yaldız, Demet, primary, Acar, Arkın, additional, Aydoğdu, Zekiye, additional, Kaya, Şeyda Örs, additional, and Yaldız, Mehmet Sadık, additional
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- 2019
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8. BİLATERAL AKCİĞER METASTAZI İLE BİRLİKTE İSKELETDIŞI YERLEŞİMLİ MEZENKİMAL KONDROSARKOM OLGUSU
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POLAT, Gülru, BÜYÜKŞİRİN, Melih, and AYDOĞDU, Zekiye
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musculoskeletal diseases ,Chondrosarcoma,pulmonary metastasis ,musculoskeletal system ,Kondrosarkom,akciğer metastazı - Abstract
Kondrosarkomlar, göğüs duvarının osteosarkomlardan sonra en sık görülen malign kemik tümörleridir. Akciğerler en sık metastaz yeridir. Sarkomların akciğer metastazları röntgenlerde genellikle değişik boyutlarda yuvarlak nodüller şeklinde görülür. Olgumuzun 3 aydır ağrı yakınması mevcutmuş. Dış merkezde çekilen Toraks BT de her iki akciğerde multipıl nodüller, sağ hiler bölgede 3 cm boyutlarında kile saptanmış. PET BT de sağ akciğer santralinde 3x4 cm boyutlu yumuşak doku lezyonu, her iki akciğerde dağınık yerleşimli düşük düzeyde 18FDG tutulumu gösteren metastatik lezyonlar, sol skapula dorsalinde kas yapı içinde izlenen kalsifik heterojen dansitede nonmetabolik lezyon izlendi. Bu lezyona yapılan trucut biyopsi patolojisi kondrosarkom şeklinde yorumlandı. Bronkoskopik biyopsi sonucu mezankimal kondrosarkom metastazı olarak değerlendirildi. Olguyu, atipik klinik prezentasyonu, bilateral akciğer ve endobronşiyal metastazı, iskeletdışı mezankimal yerleşimli kondrosarkom olması nedeniyle sunmayı uygun gördük., Chondrosarcomas are the most frequently occurring primary malign chest wall tumors. Lungs are the most frequent sites for metastases. Pulmonary metastases from sarcomas usually appear as round nodules of varying size on roentgenograms. Here, we report a case who has right side pain. Thoracal CT revealed multiple nodules in both lungs, right hiler mass . Nonmetabolic lesion seen in back of left scapula. Trucut biopsy revealed the diagnosis of chondrosarcoma. Bronchoscopic biopsy is evaluated as metastasis of mesenchymal chondrosarcoma. We presented the case because of atypical clinical presentation, existence of endobronchial metastasis and bilateral pulmonary metastasis and extraskeletal mesenchymal localization of chondrosarcoma.
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- 2017
9. A case of endometrium adenocarcinoma with multiple cavitary pulmonary metastasis
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VAYISOĞLU ŞAHİN, Görkem, primary, KARADENİZ, Gülistan, additional, POLAT, Gülru, additional, DEMİRCİ ÜÇSULAR, Fatma, additional, AYDOĞDU, Zekiye, additional, and YALNIZ, Enver, additional
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- 2018
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10. The relation between distant metastasis and genetic change type in stage IV lung adenocarcinoma patients at diagnosis.
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Ermin, Sinem, Batum, Özgür, Saka Güvenç, Merve, Diniz, Gülden, Ayrancı, Aysu, Erdoğan, Kadri Murat, Yücel, Nur, Yıldırım, Eylem, Özdemir, Taha Reşid, Hacar, Alev Gülşah, Güldaval, Filiz, Koç, Altuğ, Aydoğdu, Zekiye, Balcı, Günseli, Özyılmaz, Berk, Akşit Yaşar, Hacer, Özer Kaya, Özge, Gayaf, Mine, Kırbıyık, Özgür, and Aksel, Nimet
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ANAPLASTIC lymphoma kinase ,BRAIN metastasis ,EPIDERMAL growth factor receptors ,DIAGNOSIS ,GENETIC mutation ,ADENOCARCINOMA - Abstract
Introduction: Brain metastasis prevalence is higher in patients with positive epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) and C‐ROS oncogene 1 (ROS‐1) fusion change in lung adenocarcinoma. Objectives: The purpose of our study is to investigate the relation between the genetic change type and the initial distant metastasis in stage IV lung adenocarcinoma patients with genetic changes. Methods: The study was conducted between January 2007 and December 2018 in a retrospective fashion with patients who had lung cancer diagnosed as stage IV adenocarcinoma. The relation between genetic mutation change (EGFR, ALK or ROS‐1) and distant metastasis was analysed. Results: A total of 845 patients were included in the study. The median age was 62 (28‐88). It was determined that lung and pleura metastases were more frequent at a significant level in patients with positive EGFR mutation (P = 0.032, P = 0.004, respectively). In patients with positive ALK fusion change, pleura metastasis was determined to be more frequent (P = 0.001). Multiple metastases were determined to be significantly more in patients with positive ALK fusion change than single metastasis (P = 0.02). Conclusion: In patients with EGFR mutant lung adenocarcinoma, lung and pleura metastasis is more frequent and pleura metastasis is more frequent in ALK positive adenocarcinoma. Additionally, multiple organ metastases are higher in ALK positive lung adenocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2021
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11. EUS-B-FNA for Left Adrenal Lesions in Non-Small Cell Lung Cancer Patients: Report of Cases and Literature Review.
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Alıcı, İbrahim Onur and Aydoğdu, Zekiye
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LUNG cancer diagnosis , *ADRENAL diseases , *CANCER patients , *DIAGNOSTIC services , *ENDOSCOPIC ultrasonography , *HEALTH services accessibility , *NEEDLE biopsy , *TUMOR classification - Abstract
The left adrenal gland (LAG) is a common metastatic site in patients with non--small-cell lung cancer. In practice, staging mainly relies on radiologic studies and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Recently, a new technique using convex probe--endobronchial ultrasound (CP-EBUS) scope through the esophagus (EUS-B) has been introduced. A complete mediastinal staging and a reach for upper-abdominal structures in a single session naturally attract attention. However, scientific data are not sufficient to clearly judge the role of this technique in the cytological diagnosis of left adrenal lesions. Therefore, we present cases in which our patients have undergone EUS-B for LAG lesions to increase the data in the literature with regard to accessibility, diagnostic performance, and rate of complications. [ABSTRACT FROM AUTHOR]
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- 2020
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12. Characteristics of Patients with Large-Cell Neuroendocrine Carcinoma of the Lung.
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Çırak, Ali Kadri, Ceylan, Kenan Can, Varol, Yelda, Karadeniz, Gülistan, Aydoğdu, Zekiye, Acar, Arkın, Balcı, Günseli, Kömürcüoğlu, Berna, Mertoğlu, Aydan, Öndeş, Zeynep, Tekgül, Serpil, Vayısoğlu, Görkem, and Yalnız, Enver
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CANCER patients ,CONFIDENCE intervals ,IMMUNOHISTOCHEMISTRY ,LUNG tumors ,NEEDLE biopsy ,NEUROENDOCRINE tumors ,SURVIVAL ,TUMOR classification ,DISEASE incidence ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,SYMPTOMS - Abstract
OBJECTIVES: Neuroendocrine tumors of the lungs are a clearly different group of tumors with definite ultrastructural, immunohistochemical, and molecular features. We reported and analyzed the incidence, clinicopathological features, surgery rates, responses to first-line therapy, and survival outcomes of this rare condition according to our lung cancer patient database. MATERIALS AND METHODS: We retrospectively collected the data of 62 patients who were histopathologically diagnosed with large cell neuroendocrine carcinoma of lung (LCNEC) between January 2010 and January 2016. RESULTS: The patients were predominantly (95%) men (male:female=59:3) with their average age being 60.3±8.6 years. Diagnosis was made by the fine-needle aspiration biopsy (NAB) in 7 patients, bronchoscopic transbronchial biopsy in 13, and surgery in 42. Nearly 43.5% of the patients presented with the tumor in the right upper lobe. Additionally, tumors of 46.8% patients could be observed in peripheral locations. Sixteen patients presented with stage 1, 17 with stage 2, 15 with stage 3, and 14 with stage 4. Median progression-free survival (PFS) was 29 months (SE: 12.2) (95% CI, 5.2-52.8 months). Progression-free survival (PFS) was significantly better in patients with low N, M0, early stage, p63 positive, and TTF-1 positive across the entire cohort. Overall survival (OS) was significantly better in patients with comparatively lower N, M0, low stage, and peripheral location. CONCLUSION: This study demonstrated a single-center experience with clinicopathologic factors and survival outcomes of LCNEC patients. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Prognostic Effects of Predominant Histologic Subtypes in Resected Pulmonary Adenocarcinomas.
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Yaldız, Demet, Kaya, Şeyda Örs, Ceylan, Kenan Can, Acar, Arkın, Aydoğdu, Zekiye, Gürsoy, Soner, and Yaldız, Sadık
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ADENOCARCINOMA ,CANCER patients ,CANCER invasiveness ,LUNG tumors ,PROGNOSIS ,SURVIVAL ,CROSS-sectional method ,RETROSPECTIVE studies - Abstract
Background: Predominant histologic subtypes have been reported as predictors of survival of patients with pulmonary adenocarcinoma. Aims: To evaluate the predictive value of histologic classification in resected lung adenocarcinoma using the classification systems proposed by the International Association for the Study of Lung Cancer, American Thoracic Society, European Respiratory Society, and World Health Organization (2015). Study Design: Cross-sectional study. Methods: The histologic classification of a large cohort of 491 patients with resected lung adenocarcinoma (stages I-III) was retrospectively analyzed. The tumors were classified according to their predominant component (lepidic, acinar, papillary, solid, micropapillary, and mucinous), and their predictive values were assessed for clinicopathologic characteristics and overall survival. Results: The patient cohort comprised 158 (32.2%) patients with solid predominant, 150 (30.5%) with acinar predominant, 80 (16.3%) with papillary predominant, 75 (15.3%) with lepidic predominant, 22 (4.5%) with mucinous, and 5 (1.0%) with micropapillary subtype, and 1 (0.2%) with adenocarcinoma in situ. Overall 5-year survival of 491 patients was found to be 51.8%. Patients with lepidic, acinar, and mucinous adenocarcinoma had 70.9%, 59.0%, and 66.6% 5-year survival, respectively, and there was no statistically significant difference between them. Whereas patients with solid, papillary, and micropapillary predominant adenocarcinoma had 41.0%, 40.5%, and 0.0% 5-year survival, respectively. Compared to other histologic subtypes, patients with solid and papillary predominant adenocarcinoma had significantly lower survival than those with lepidic (p<0.001, p=0.002), acinar (p<0.001, p=0.008), and mucinous (p=0.048, p=0.048) subtypes, respectively. The survival difference between patients with solid subtype and those with papillary subtype was not statistically significant (p=0.67). Conclusion: Solid and papillary histologic subtypes are poor prognostic factors in resected invasive lung adenocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2019
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14. Contribution of Cell Block Obtained by Thoracentesis in the Diagnosis of Malignant Pleural Effusion.
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Güldaval, Filiz, Anar, Ceyda, Polat, Gülru, Gayaf, Mine, Yavuz, Melike Yüksel, Korkmaz, Ali, Alıcı, İbrahim Onur, Karadeniz, Gülistan, Büyükşirin, Melih, and Aydoğdu, Zekiye
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LUNG cancer diagnosis ,ADENOCARCINOMA ,CHEST paracentesis ,CYTODIAGNOSIS ,CYTOLOGY ,EXUDATES & transudates ,HISTOLOGICAL techniques ,PLEURA cancer ,PLEURAL effusions ,DATA analysis ,PREDICTIVE tests ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Aim: The aim of this study wass to compare the cytological features of pleural exudative fluids by conventional smear (CS) method and cell block (CB) method and also to assess the utility of the combined approach for cytodiagnosis of these effusions. Materials and Methods: In all, 113 pleural exudative fluid samples were subjected to evaluation by both CS and CB methods over a period of 2 years. Cellularity, architecture patterns, morphological features, and yield for malignancy were compared, using the two methods. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosis of malignancy were calculated for both the methods, using histology as a gold standard. Results: CB method provided higher cellularity, better architectural patterns, and additional yield for malignancy when compared with CS method. For 22 (40%) patients, histologic subtype was determined with CB especially for adenocarcinoma. The sensitivity, specificity, positive, and negative predictive values of cytology and CB were 48%, 100%, 100%, 67.8% and 59.2%, 100%, 100%, 72.8%, respectively. Conclusion: CB technique definitively increased detection of malignancy in pleural fluid effusion when used as an adjunct to CSs. Also, CB provides material suitable for molecular genetic analysis for targeted therapies especially in the treatment of adenocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2019
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15. SPONTANEOUS REMISSION IN LANGERHANS CELL HISTIOCYTOSIS: A CASE REPORT
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YAVUZ, Melike Yüksel, ANAR, Ceyda, YALÇINKAYA, Erdem, ÜNSAL, İpek, GÜLDAVAL, Filiz, DENİZ, Derya, HALİLÇOLAR, Hüseyin, and AYDOĞDU, Zekiye
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Smoking,Langerhans Hücreli Histiyositosiz,treatment,spontan regression ,Sigara,Langerhans Hücreli Histiyositosiz,tedavi,spontan regre - Abstract
Pulmoner eozinofilik granülom olarak da bilinen Langerhans hücreli histiyositoz, pulmoner Histiyositoz- X sendromuna ait bir interstisyel akciğer hastalığıdır. Genç sigara içen hastalarda daha sık görülmektedir. Tanı klinik ve tipik radyolojik bulgularla konulabilse de esas tanı patolojik incelemeyle konulur. Tedavinin temelini sigarayı bıraktırma oluşturur. Beş aydır eforla artan nefes darlığı yakınması ile polikliniğimize başvuran 39 yaşında bayan hastanın 15 yıl bir paket/gün sigara içme öyküsü mevcuttu. Yüksek rezolüsyonlu toraks bilgisayarlı tomografisinde her iki akciğer parankim alanlarında üst ve orta zonlarda daha belirgin, alt zonlarda daha hafif ve küçük, kaviter ve kistik nodüler lezyonlar mevcuttu. Bronkoalveolar lavaj sıvısının immünohistokimyasal boyamasında S- 100 yüzey antijeni pozitifliği gösteren Langerhans hücreleri görüldü. Sadece akciğer tutulumu olan ve sigaranın bırakılması ile lezyonlarında gerileme görülen olgumuzu sunmayı uygun bulduk., Langerhans Cell Histiocytosis, also known as pulmonary eosinophilic granuloma, is a part of the pulmonary histiyositozis-X syndrome and is a form of interstitial lung disease. It is common among young smoker patients. Although the diagnosis is based on the clinical and typical radiological findings, pathological examination is necessary for final diagnosis. Smoking cessation is main stay of treatment. A 39-year-old female patient referred to our clinic with the complaint of dispne for the last five months. She is a current smoker and had a smoking history of 15 packedyear. In high resolution computed tomography, cystic-cavitary appearances markedly in upper lobes were observed. Bronchoalveolar lavage showed some Langerhans cells with S-100 antigen positivity. We report a case of eosinophilic granuloma in whom spontaneous disease regression was obtained with only smoking cessation.
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- 2015
16. The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal tuberculous lymphadenitis
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ERER, Onur Fevzi, primary, EROL, Serhat, additional, ANAR, Ceyda, additional, BİÇMEN, Can, additional, AYDOĞDU, Zekiye, additional, and AKTOĞU, Serir, additional
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- 2017
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17. Diagnostic yield of EBUS-TBNA for lymphoma and review of the literature
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Anar, Ceyda, primary, Erer, OnurFevzi, additional, Erol, Serhat, additional, Aydoğdu, Zekiye, additional, and Özkan, SerirAktoğu, additional
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- 2017
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18. Contribution of cell block obtained by endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of malignant diseases and sarcoidosis
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Anar, Ceyda, primary, Erer, OnurFevzi, additional, Erol, Serhat, additional, Aydoğdu, Zekiye, additional, and Özkan, SerirAktoğu, additional
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- 2017
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19. GASTROINTESTINAL, RENAL AND PULMONARY İNVOLVEMENT: A RARE WEGENER GRANULOMATOSIS CASE
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TAYMAZ, Zühre Sarp, MERTOĞLU, Aydan, TELLİOĞLU, Emel, BALCI, Günseli, YURT, Yasemin, and AYDOĞDU, Zekiye
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Wegener granulomatozu,nekrotizan vaskülit,gastroinestinal kanama,hemoptizi ,Wegener's granulomatosis,necrotizing vasculitis,gastrointestinal hemorrhage,heamoptysis - Abstract
Wegener granulomatozu (WG), özellikle üst ve alt solunum yolları ile böbrekleri tutabilen nekrotizan granulomatöz vaskülitle tanımlanan nadir sistemik bir hastalıktır. Bu hastalığın nadir de olsa başka organ sistemlerini de etkilediği bilinmektedir. 72 yaşında erkek hastamızda benign prostat hipertrofisi operasyonu için yapılan preoperatif değerlendirme için çekilen toraks bilgisayarlı tomografisinde “sağ akciğer üst lob posterior segment lokalizasyonunda geniş bir tabanla plevraya invazyon gösteren yaklaşık 4x5cm ebatlarda santralinde geniş nekroz alanları da saptanan düzensiz konturlu malign kitle lezyonu, sağ akciğer üst lob anterior segmentte subplevral parankimde yaklaşık 2x2.5cm çaplara ulaşan düzensiz sınırlı nodül” izlendi. Yapılan tetkiklerle sistemik tip WG tanısı kondu. Hastada sistemik tedaviye başlanmadan önce tetkikleri sırasında yaşamı tehdit eden hemoptizi ve gastrointestinal kanama gelişti. Hastada endoskopi ve kolonoskopi yapıldı. WG'un barsak tutulumu olduğu düşünülerek kortikosteroid ve siklofosfamid tedavisi başlandı ve tedaviyle dramatik yanıt alındı. Hastanın gastrointestinal kanamasının uygulanan kortikosteroid ve siklofosfamid tedavisi ile dramatik iyileşme göstermesi ve WG'da gastrointestinal sistem tutulumun nadir görülmesi nedeni ile hasta literatür bilgileri eşliğinde sunuldu., Wegener granulomatosis (WG) is a rare systemic disease which is characterized with necrotizing granulomatous vasculitis affecting upper and lower respiratory tract and kidneys. It is known that this disease may rarely affect other organ systems. 72-years-old male patient was diagnosed to have “a 4x5 cm diameter irregular contoured malign mass lesion with a large necrotic center localized and invasing adjacent pleura in right upper lobe posterior segment and another 2x2.5 cm diameter irregular contoured nodule localized in subpleural region of right upper lobe anterior segment” in his thorax computerized tomography during preoperative evaluation for benign prostate hypertrophy operation. He was diagnosed to have systemic type WG. Before starting systemic therapy, during the diagnosis period, he had lifethreatening heamoptysis and gastrointestinal bleeding. Endoscopy and colonoscopy were performed. Corticosteroid and cyclophosphamide therapy was initiated as intestinal involvement of WG was considered and had a dramatic response after treatment. He is presented because the gastrointestinal bleeding recovered dramatically by corticosteroid and cyclophosphamide therapy and because gastrointestinal system involvement is a rare entity in WG.
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- 2014
20. Multipl kaviter akciğer metastazı yapan endometriyum adenokarsinom olgusu.
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VAYıSOĞLU ŞAHİN, Görkem, KARADENİZ, Gülistan, POLAT, Gülru, DEMİRCİ ÜÇSULAR, Fatma, AYDOĞDU, Zekiye, and YALNıZ, Enver
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- 2018
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21. INTERACTIVE CASE REPORT: Hypersensitivity Pneumonitis: Report of Seven Cases
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Demirci Üçsular, Fatma, primary, Anar, Ceyda, additional, Yalnız, Enver, additional, and Aydoğdu, Zekiye, additional
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- 2015
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22. Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage.
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Hoşgörler, Ferda, Keleş, Didem, Tanrıverdi-Akhisaroğlu, Serpil, İnanç, Şeniz, Akhisaroğlu, Mustafa, Cankurt, Ülker, Aydoğdu, Zekiye, Uçar, Ahmet Deniz, Çetinayak, Oğuz, Oktay, Gülgün, and Arda, Sevil Gönenç
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Background: Matrix metalloproteinase (MMP) inhibitors decrease inflammation in normal tissues and suppress cancer progress in normal tissues. Valproic acid (VA) and doxycycline (DX) are MMP inhibitors that have radio-protective effects. Their ability to inhibit MMPs in irradiated tissue is unknown and the role of MMPs in radio-protective effects has not been tested to date. Aims: The purpose of this study was to examine whether administration of VA and DX to rats before irradiation affects tissue inflammation and apoptosis in the early phase of radiation, and whether the effect of these drugs is mediated by MMP inhibition. Study Design: Animal experimentation. Methods: Twenty-six Wistar rats were randomized into four groups: control (CTRL), radiation (RT), VA plus radiation (VA+RT), and DX plus radiation (DX+RT). Three study groups were exposed to a single dose of abdominal 10 Gy gamma radiation; the CTRL group received no radiation. Single doses of VA 300 mg/kg and DX 100 mg/kg were administered to each rat before radiation and all rats were sacrificed 8 hours after irradiation, at which point small intestine tissue samples were taken for analyses. Levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6) and matrix metal- loproteinases (MMP-2 and MMP 9) were measured by ELISA, MMP activities were measured by gelatin and casein zymography and apoptosis was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Results: VA decreased the levels of TNF-a and IL-1β proteins insignificantly and decreased apoptosis significantly in the irradiated tissue, but did not inhibit MMPs. In contrast, VA protected the basal MMP activities, which decreased in response to irradiation. No effect of DX was observed on the levels of inflammatory cytokines or activities of MMPs in the early phases of radiation apoptosis. Conclusion: Our findings indicated that VA protects against inflammation and apoptosis, and DX exhibits anti-apoptotic effects in early radiation and these effects are independent from MMP inhibition. [ABSTRACT FROM AUTHOR]
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- 2016
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23. Yedi Olgu Nedeniyle Hipersensitivite Pnömonisi.
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Üçsular, Fatma Demirci, Anar, Ceyda, Yalnız, Enver, and Aydoğdu, Zekiye
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Copyright of Respiratory Case Reports is the property of LookUs Scientific and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2015
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24. The prognostic significance of PD-1 and its ligands in non-small cell lung cancer.
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Usluer O, Gökbayrak ÖE, Erol A, Aktaş TÇ, Batıhan G, Örs Kaya Ş, Üçvet A, Aydoğdu Z, Altun Z, Öztop İ, and Aktaş S
- Abstract
Background: In this study, we aimed to investigate the prognostic value of programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), and programmed cell death ligand 2 (PD-L2) expressions on immune and cancer cells in terms of survival in patients with lung adenocarcinoma, squamous cell carcinoma, and large cell carcinoma., Methods: Between January 2000 and December 2012, a total of 191 patients (172 males, 19 females; mean age: 60.3±8.4 years; range, 38 to 78 years) who were diagnosed with non-small cell lung cancer and underwent anatomic resection and mediastinal lymph node dissection were retrospectively analyzed. The patients were evaluated in three groups including lung squamous cell carcinoma (n=61), adenocarcinoma (n=66), and large-cell carcinoma (n=64). The survival rates of all three groups were compared in terms of immunohistochemical expression levels of PD-1, PD-L1, and PD-L2., Results: The mean follow-up was 71.8±47.9 months. In all histological subtypes, PD-1 expressions on tumor and immune cells were observed in 33% (61/191) and in 53.1% (102/191) of the patients, respectively. Higher expression levels of PD-L1 and PD-L2 at any intensity on tumor and immune cells were defined only in lung adenocarcinomas, and PD-L1 and PD-L2 values were detected in 36.4% (22/64) of these patients. The PD-L1 expressions on tumor and immune cells were observed in 41.7% (10/24) and 25% (6/24) of the patients, respectively. The PD-L2 expressions on tumor and immune cells were detected in 16.7% (4/24) and 8.4% (2/24) of the patients, respectively. Univariate and multivariate analyses revealed that PD-1 expression in tumor cells was an independent prognostic factor in all histological subtypes., Conclusion: Our study results suggest that PD-1 expression is a poor prognostic factor for overall survival in patients with completely resected adenocarcinoma, squamous cell carcinoma, and large cell carcinoma., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2024, Turkish Society of Cardiovascular Surgery.)
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- 2024
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25. Papillary predominant histological subtype predicts poor survival in lung adenocarcinoma.
- Author
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Yaldız D, Acar A, Örs Kaya Ş, Aydoğdu Z, Gürsoy S, and Yaldız S
- Abstract
Background: This study aims to investigate whether papillary predominant histological subtype can predict poor survival in lung adenocarcinoma., Methods: Between January 2005 and December 2016, a total of 80 patients with papillary predominant subtype lung adenocarcinoma (70 males, 10 females; mean age 60.7 years; range, 42 to 79 years) operated in our clinic were included in the study. These patients were compared with those having lepidic, acinar, and mucinous subtypes. Overall and five-year survival rates were evaluated., Results: Five-year survival was 40.5% in papillary predominant histological subtype, while this rate was 70.9%, 59.0%, and 66.6% in lepidic, acinar, and mucinous subtypes, respectively. Papillary subtype showed significantly poor survival compared to lepidic (p=0.002), acinar (p=0.008), and mucinous subtypes (p=0.048). In Stage 1 disease, it was more evident (papillary, 47.5%, lepidic 86.9% [p=0.001], acinar 69.3% [p=0.040], and mucinous 90.0% [p=0.050])., Conclusion: Our study results suggest that papillary predominant subtype predicts poor survival in lung adenocarcinoma and these cases may be candidates for adjuvant treatment modalities even in the earlier stages of disease., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2019, Turkish Society of Cardiovascular Surgery.)
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- 2019
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26. [A case of endometrium adenocarcinoma with multiple cavitary pulmonary metastasis].
- Author
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Vayısoğlu Şahin G, Karadeniz G, Polat G, Demirci Üçsular F, Aydoğdu Z, and Yalnız E
- Subjects
- Adenocarcinoma diagnosis, Aged, Biopsy, Bronchoscopy, Female, Humans, Lung Neoplasms diagnosis, Neoplasm Metastasis, Tomography, X-Ray Computed, Adenocarcinoma secondary, Endometrial Neoplasms pathology, Lung Neoplasms secondary
- Abstract
Pulmonary metastases are usually seen as parenchymal nodules, lymphatic-interstitial spread and pleural effusion, however cavitary and cystic metastatic lesions are rare. While breast cancer, gastrointestinal tumors, kidney tumors, malignant melanoma, sarcomas, lymphoma and leukemia mostly metastasize to the lung, endometrial adenocarcinoma rarely metastasizes. A 73-year-old woman with multiple cystic-cavitary lung lesions was referred to our clinic because of chronic cough. She had endometrial adenocarcinoma metastasis to the lung. We wanted to present our case because of the rare occurrence of cystic-cavitary lung metastases and the rare presentation of metastasis of endometrial carcinomas to the lung.
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- 2018
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27. Diagnostic yield of EBUS-TBNA for lymphoma and review of the literature.
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Erer OF, Erol S, Anar C, Aydoğdu Z, and Özkan SA
- Abstract
Aim: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), which enables cytological examination of mediastinal lymph node (LN) aspiration samples, is a safe and minimally invasive method for diagnosis and staging of lung cancer and diagnosis of diseases affecting mediastinal LNs. In this study, we investigated the yield of EBUS-TBNA for diagnosis of lymphoma and reviewed the literature since the British Thoracic Society (BTS) guidelines were published., Materials and Methods: We retrospectively evaluated our database for patients who underwent EBUS between March 2011 and December 2014. One hundred eighty-nine patients with isolated mediastinal lymphadenopathy were included in the study. Patients with other causes of lymphadenopathy, such as lung cancer or extrathoracic malignancy, and those with pulmonary lesions accompanying mediastinal lymphadenopathy were excluded from the study. Patients with final diagnosed lymphoma were included in the study on the basis of a history of lymphoma or newly evaluated mediastinal lymphadenopathy. The sensitivity and negative predictive value (NPV) of EBUS-TBNA were calculated., Results: There were 13 patients with the final diagnosis of lymphoma. Eleven of them were new diagnoses and 2 patients were known chronic lymphocytic leukemia (CLL), and underwent EBUS-TBNA for determination of recurrence. Twelve EBUS-TBNA procedures were performed for suspected new cases. Three (25%) were diagnostic, 2 (16.7%) were suspicious for lymphoma and underwent further interventions for definite diagnosis, and 7 (58.3%) were false negative. All 3 patients diagnosed with EBUS-TBNA were non-Hodgkin lymphoma (NHL). None of the Hodgkin lymphoma (HL) cases could be diagnosed with EBUS-TBNA. The overall diagnostic sensitivity and NPV of EBUS-TBNA in detecting lymphoma was 65% and 96.1%, respectively. For the newly diagnosed lymphoma cases, EBUS-TBNA had a sensitivity of 61.1%., Conclusion: In conclusion, we believe that since the publication of the BTS guidelines, the value of EBUS-TBNA in the diagnosis of lymphoma still remains controversial. EBUS-TBNA can be the first diagnostic modality in diagnosis of recurrent lymphomas. However, for suspected new cases, especially for HL, the diagnostic yield of EBUS-TBNA is low and negative results do not exclude lymphoma. Further interventions such as mediastinoscopy should be performed for high-suspicion patients.
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- 2017
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28. Contribution of cell block obtained by endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of malignant diseases and sarcoidosis.
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Erer OF, Erol S, Anar C, Aydoğdu Z, and Özkan SA
- Abstract
Aim: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a safe and minimally invasive procedure that can be performed in outpatient settings. Several studies have demonstrated the usefulness of EBUS-TBNA in the diagnosis of sarcoidosis and malignant diseases. This study focused on the role of cell block (CB) analysis in determining the diagnostic yield of EBUS-TBNA in malignant diseases and sarcoidosis., Materials and Methods: The study was conducted at a training and research hospital. Records of patients who underwent EBUS-TBNA between March 2011 and December 2014 for diagnosed sarcoidosis or malignancy were retrospectively analyzed. Results of all EBUS-TBNA smears and CB were separately evaluated to determine the diagnostic value of each., Results: There were 84 sarcoidosis and 179 malignancy patients. In the malignancy group, CB contributed to cancer diagnosis in 15 (8.3%) patients and subclassification in 19 (10.6%) patients. In the sarcoidosis group, for 45.2% of patients (38/84), smears were not diagnostic but CB showed granulomatous inflammation., Conclusion: CB significantly increases the diagnostic yield of EBUS-TBNA for sarcoidosis. In our study, in the malignancy group the diagnostic yield was low but it was helpful for subclassification, especially for adenocarcinoma.
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- 2017
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