1. Anti- Sporothrix spp. activity of medicinal plants
- Author
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Stefanie Bressan Waller, Mário Carlos Araújo Meireles, Isabel Martins Madrid, João Roberto Braga de Mello, Marlete Brum Cleff, and Renata Osório de Faria
- Subjects
0301 basic medicine ,Combretaceae/farmacognosia ,030106 microbiology ,lcsh:RS1-441 ,Lamiaceae/farmacognosia ,lcsh:Pharmacy and materia medica ,Asteraceae/farmacognosia ,03 medical and health sciences ,Asteraceae/pharmacognosy ,Plantas medicinais/atividade antifúngica ,medicine ,Sporothrix schenckii ,Lamiaceae/pharmacognosy ,General Pharmacology, Toxicology and Pharmaceutics ,Medicinal plants ,Antifungals ,Combretaceae ,Combretaceae/pharmacognosy ,biology ,Sporotrichosis ,business.industry ,Study methodology ,Sporothrix ,Sporothrix schenckii complex ,Asteraceae ,biology.organism_classification ,medicine.disease ,Biotechnology ,Lamiaceae ,business ,Medicinal plants/antifungal activity ,Antifúngicos - Abstract
Cases of sporotrichosis in humans and animals without satisfactory clinical response have increased, a warning sign of strains resistant to conventional antifungal agents. The urgent search for alternative therapies was an incentive for research on medicinal plants with anti-Sporothrix spp. properties. A bibliographic survey was performed based on scientific papers about in vitro and in vivo antifungal activity of essential oils and extracts of plants in differents solvents against the fungal of the Sporothrix schenckii complex. The study methodology consisted of a literature review in Google Scholar, Science Direct, Pubmed, Bireme and Springer link with papers from 1986 to 2015. We found 141 species of plants that were investigated, of which 100 species were concentrated in 39 botanical families that had confirmed anti-Sporothrix activity. Combretaceae, Asteraceae and Lamiaceae represented the botanical families with the greatest number of plants species with antifungal potential, using different methodologies. However, there are few studies with medicinal plants in experimental infection in animals that prove their activity in the treatment of sporotrichosis. It reinforces the need for further research related to standardization of in vitro methodologies and in vivo studies related to safety and to toxicity potential of these plants with anti-Sporothrix spp. activity. RESUMO Casos de esporotricose em humanos e animais sem resposta clínica satisfatória têm aumentado, sinal de alarme para o surgimento de cepas resistentes aos antifúngicos convencionais. A urgente busca por alternativas terapêuticas tem incentivado as pesquisas em plantas medicinais com atividade anti-Sporothrix spp. Um levantamento bibliográfico foi realizado com base em artigos científicos sobre a atividade antifúngica in vitro e in vivo de óleos essenciais e extratos de plantas preparados em diferentes solventes contra o complexo Sporothrix schenckii. A metodologia do estudo consistiu em uma revisão bibliográfica em Google Scholar, Science Direct, Pubmed, Bireme e Springer link com artigos desde 1986 até 2015. Foram encontradas 141 espécies de plantas já investigadas, das quais 100 espécies concentradas em 39 famílias botânicas apresentaram atividade anti-Sporothrix spp. confirmada. Combretaceae, Asteraceae e Lamiaceae representaram as famílias botânicas com maior número de espécies vegetais com potencial antifúngico, empregando diferentes metodologias. Entretanto, há poucos estudos com plantas medicinais em infecção experimental animal comprovando sua atividade no tratamento da esporotricose. Reforça-se a necessidade de mais pesquisas relacionadas à padronização de metodologias in vitro e a estudos in vivo relacionados à segurança e potencial tóxico dessas plantas com atividade anti-Sporothrix spp.
- Published
- 2016