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1. The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections

Author

Buetti, Niccolò, Tabah, Alexis, Setti, Nour, Ruckly, Stéphane, Barbier, François, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Bassetti, Matteo, Morris, Andrew Conway, Arvaniti, Kostoula, Paiva, José-Artur, Ferrer, Ricard, Qiu, Haibo, Montrucchio, Giorgia, Cortegiani, Andrea, Kayaaslan, Bircan, De Bus, Liesbet, De Waele, Jan J., and Timsit, Jean-François

Published
2024
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2. Correction: The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections

Author

Buetti, Niccolò, Tabah, Alexis, Setti, Nour, Ruckly, Stéphane, Barbier, François, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Bassetti, Matteo, Morris, Andrew Conway, Arvaniti, Kostoula, Paiva, José-Artur, Ferrer, Ricard, Qiu, Haibo, Montrucchio, Giorgia, Cortegiani, Andrea, Kayaaslan, Bircan, De Bus, Liesbet, De Waele, Jan J., and Timsit, Jean-François

Published
2024
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6. Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

Author

Tabah, Alexis, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Akova, Murat, Aslan, Abdullah Tarik, and Leone, Marc

Subjects
Pfizer Inc., Medical research -- Analysis -- Health aspects, Medicine, Experimental -- Analysis -- Health aspects, Drug resistance in microorganisms -- Analysis -- Health aspects, Pharmaceutical industry -- Health aspects -- Analysis, Health care industry
Abstract

Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods We carried out a prospective international cohort study of adult patients ([greater than or equal to] 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes., Author(s): Alexis Tabah [sup.1] [sup.2] [sup.3] [sup.4], Niccolò Buetti [sup.5] [sup.6], Quentin Staiquly [sup.7], Stéphane Ruckly [sup.6] [sup.7], Murat Akova [sup.8], Abdullah Tarik Aslan [sup.9], Marc Leone [sup.10], Andrew Conway [...]

Published
2023
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7. Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates

Author

Isler, Burcu, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Stewart, Adam, Simos, Peter, Falconer, Caitlin, Bauer, Michelle J., Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem, Akova, Murat, Ergönül, Önder, Paterson, David L., and Can, Füsun

Published
2022
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8. Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Author

Buetti, Niccolò, Tabah, Alexis, Loiodice, Ambre, Ruckly, Stéphane, Aslan, Abdullah Tarik, Montrucchio, Giorgia, Cortegiani, Andrea, Saltoglu, Nese, Kayaaslan, Bircan, Aksoy, Firdevs, Murat, Akova, Akdoğan, Özlem, Saracoglu, Kemal Tolga, Erdogan, Cem, Leone, Marc, Ferrer, Ricard, Paiva, José-Artur, Hayashi, Yoshiro, Ramanan, Mahesh, Conway Morris, Andrew, Barbier, François, and Timsit, Jean-François

Published
2022
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10. Epidemiology and clinical significance of carbapenemases in Australia: a narrative review.

Author

Aslan, Abdullah Tarik and Paterson, David L.

Subjects
*ANTIBIOTICS, *CARBAPENEMS, *DRUG resistance in microorganisms, *GRAM-negative aerobic bacteria, *ENTEROBACTERIACEAE, *DISEASES, *ESCHERICHIA coli, *DRUG approval, *GRAM-negative bacterial diseases, *PUBLIC health, *BETA lactamases, *PHYSICIANS, *PSEUDOMONAS, *MEDICAL care costs, *KLEBSIELLA
Abstract

Carbapenemase‐producing gram‐negative bacteria (CP‐GNB) infections threaten public health with high mortality, morbidity and treatment costs. Although frequencies remain low in Australia (total number of CP‐GNB infections reported was 907 in 2022), blaIMP‐4 has established low levels of endemicity in many states. Imipenemase metallo‐β‐lactamase types alone accounted for more than half of all carbapenemases in carbapenemase‐producing Enterobacterales isolates in Australia, particularly in Enterobacter cloacae complex. New Delhi metallo‐β‐lactamase constitutes almost 25% of all carbapenemases in Australia and was identified predominantly in Escherichia coli. The OXA‐48‐like carbapenemases include almost 10% of all carbapenemases and are mainly seen in Klebsiella pneumoniae and E. coli. Although K. pneumoniae carbapenemase‐type carbapenemases are rare in Australia, some local outbreaks have occurred. Most carbapenem‐resistant (CR) Pseudomonas aeruginosa strains in Australia do not produce carbapenemases. Finally, OXA‐23‐like carbapenemases are overwhelmingly positive in CR‐Acinetobacter baumannii strains in Australia. Treatment of CR‐GNB infections challenges physicians. Of 10 new antibiotics active against at least some CR‐GNB infections that are approved by the US Food and Drug Administration, just three are approved for use in Australia. In this context, there is still an unmet need for novel antibacterials that can be used for the treatment of CR‐GNB infections in Australia, as well as a pressing requirement for new mechanisms to 'de‐link' antibiotic sales from their availability. In this narrative review, we aim to overview the epidemiology and clinical significance of carbapenem resistance in Australia as it pertains to Enterobacterales, P. aeruginosa and A. baumannii. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

Author

Rashidi, Mahboobeh, Hamid, Hytham K S, Saidahmed, Elfayadh, Karar, Ali Adil Ali, Mc Cree, Melanie, Adeola, Fowotade, Idowu, Olusola, Oladimeji, Motunrayo, Asiyanbi, Gabriel, Desalu, Ibironke, Olatosi, John O, Ugwu, Euphemia Mgbosoro, Yakubu, Saidu Yusuf, Misra, Krushna Chandra, Sheshala, Kaladhar, Mukherjee, Sudipta, Ghosh, Pralay, Chandran, Jagadish, Dsilva, Carol, Baby, Sailaja K, Renuka, M K, Patel, Mayur, Rathod, Darshana, Datta, Avijatri, Bose, Payel, Siddiqui, Suhail Sarwar, Ozair, Ahmad, Muzaffar, Syed Nabeel, Shekhar, Saurav, Singh, Ritu, Pahuja, Madhumati, Jain, Nikhilesh, Rubina, Noor Ahmedi, Vaidyanathan, R, Samdani, Pratit, Nimbolkar, Janardan, Sharma, Priya, Karmakar, Saurabh, Sharma, Ankur, Kothari, Nikhil, Baronia, Arvind, Gurjar, Mohan, Islam, Mohammad Motiul, Hasan, Rajib, Huq, Shihan Mahmud Redwanul, Rabbani, Raihan, Hewer, Tayne, Thompson, Patricia, Sligl, Wendy, Kutsogiannis, Demetrios J, McCoshen, Lorena, Baig, Nadia, Burma, Yaroslava, Sokhan, Anton, Renaud, Paul Jean, Humphreys, Miss Sally K, Tilley, Rebecca E, Patel, Jamie, Attwood, Ben, Chikungwa, Moses, Jackson, Matthew, Zaki, Ahmed, Banach, Dorota, Torre, Valentina Della, Marsden, Nicholas, Antrolikar, Supriya, Kannan, Santhana, Mckee, Rachel, Mcguigan, Peter, Baikady, R Rao, Jhanji, S, Black, E, Husain, A, Loftus, S, Tatham, Kate, Hall, Daniel, Longbottom, Rebecca, Baumer, Tom, Szakmany, Tamas, Roshdy, Ashraf, Sanderson, Amanda, Ritzema, Jenny, Keegan, Allison, Cerman, Jaroslav, Graham, Clive, Smith, Tim, Cole, Stephen, Cobb, Katherine, Parcell, Benjamin J, Angell, Hollie, Hugill, Keith, Franke, Uwe, Arias, Sonia Sousa, Templeton, Maie, Lennard, James, Macfie, Caroline, Johnson, Aimee, Dolan, Rachael, Yonan, Aimee, Soltan, Marina, Bajaj, Manan, Goyal, Shraddha, Mulhi, Randeep, Torlinski, Tomasz, Khade, Reena, Tinaslanidis, George, Zormpa, Artemis, Raj, Ashok, Kent, Melanie, Cowton, Amanda, Faulkner, Maria, Tizard, Kate, Rojo, Roceld, Antcliffe, David, Ercole, Ari, Morris, Andrew Conway, Routledge, Matthew, Aktas, Sabahat Cagan, Batirel, Ayse, Akyol, Ahmet, Goksu, Senay, Ersoy, Yasemin, Bayindir, Yasar, Altin, Nilgün, Gürbüz, Yunus, Erdoğan, Cem, Ozgen, Cansu, Sungurtekin, Hulya, Evik, Guliz, Ersoz, Gulden, Guzeldag, Seda, Bilir, Yeliz, Saracoglu, Kemal Tolga, Eroglu, Ahmet, Aksoy, Firdevs, Koksal, Iftihar, Karaali, Ridvan, Saltoglu, Nese, Cakmak, Rumeysa, Tunay, Burcu, Yilmaz, Mesut, Akdogan, Ozlem O, Baykam, Nurcan N, Çolak, Onur, Agalar, Canan, Sari, Ali, Gundogan, KÜRŞAT, Akbas, Türkay, Çolak, Sait, Demiray, Emine Kubra Dindar, Erol, Çiğdem, Ozturk, Barcin, Telli, Murat, Kurt, Ibrahim, Kalem, Ayşe Kaya, Kayaaslan, Bircan, Talan, Leyla, Altintas, Neriman Defne, Ceyhun, Solakoğlu, Mehtap, Selcuk, Kusoglu, Hulya, Kocagoz, Sesin, Timuroglu, Arif, Aslan, Abdullah Tarik, Akova, Murat, Abed-Maillard, S, Pagani, Jl, Jakob, Stephan, Prazak, Josef, De Geer, Lina, Åkerlund, Joyce, Edin, Alicia, Haney, Michael, Svensson, Carl Johan, Spahic, Dzana, Sjövall, Fredrik, Gallego, Alberto Orejas, Blasco-Navalpotro, Miguel Angel, Novo, Mariana, Ayestaran, J Ignacio, De La Rica, Alejandro Suarez, Maseda, Emilio, Rodriguez, Dra M, Asensio, Dra Mj, Prieto, Emilio Garcia, Espina, Lorena Forcelledo, Salgado, Dra Maria, Ubeda, Alejandro, Gomà, Gemma, Santos, Emilio Diaz, Quesada, María Dolores, Raguer, Laura, Roig, Regina, Catalan, Beatriz, Armestar, Fernando, Bermudez, Rosana Munoz, Arnillas, Maria Pilar Gracia, Amerigo, Joaquin Amador, Flores, Matias, Vera, Paula, Casares, Vanessa, Martinez, Maria, Rocca, Ricard Ferrer, Furman, Mikhail, Belskiy, Vladislav, Chukina, Maria, Vistovskaya, Natala, Eremenko, Aleksandr, Gaigolnik, Denis, Tribulev, Maksim, Zubareva, Nadezhda, Magomedov, Marat, Meleshkina, Yulia, Anderzhanova, Anastasia, Gritsan, Alexey, Lungu, Olguta, Grigoras, Ioana, Marcu, Alexandra, Popescu, Mihai, Tomescu, Dana, Predoi, Cornelia Elena, Filipescu, Daniela Carmen, Cobilinschi, Cristian, Grintescu, Ioana Marina, Bubenek-Turconi, Serban, Valeanu, Liana, Mendes, António Carvalho, Pereira, Énio, Moura, José Pedro, Nunes, Cristina, Pascoalinho, Dulce, Queiró, Joana, Ledo, Sara, da Costa, Tito, Molinos, Elena, Cunha, Rui Pedro, Costa, Vasco, Duarte, Tiago, Botelho, Isabel, de Figueiredo, António Manuel Pereira, Teresa, Ana, Krystopchuk, Andriy, Pinto, Ana Rios, Marques, Ana Josefina Pinheiro, Alves, Madalena, Guimarães, Nádia, Pereira, Tiago, Cartoze, Nuno, Bisanti, Alessandra, Martin-Loeches, Ignacio, Pietraszek-Grzywaczewska, Iwona, Peichota, Mariusz, Broda, Hanna, Nowakowski, Tomasz, Wasowska, Dominika, Walczak-Wieteska, Paulina, Kotkowska, Anna, Bojko, Jozef, Szczesniak, Anna, Komorowska, Irmina Kaptur, Tamowicz, Barbara, Mikstacki, Adam, Rizzo, Anna Chiara, Cotoia, Antonella, Fiorelli, Silvia, Rocco, Monica, Covotta, Marco, Pelagalli, Lorella, Di Guardo, Andrea, Bellina, Davide, Ippolito, Mariachiara, Cortegiani, Andrea, Battaglini, Denise, Pelosi, Paolo, Schlevenin, Maria Grazia, Zuccaro, Francesco, Lodi, Giovanni, Daroui, Ivan, Mirabella, Michele, Porcile, Elisa, Gratarola, Angelo, Giacobbe, Daniele Roberto, Di Gravio, Valentina, Vargas, Joel, Carelli, Simone, Montini, Luca Maria, De Pascale, Gennaro, Sales, Gabriele, Montrucchio, Giorgia, Papathanakos, Georgios, Kouroulas, Vasilios, Retselas, Ioannis, Theodorou, Vasiliki, Marouli, Diamantina, Malliotakis, Polychronis, Almiroudi, Mariota Panagiota, Dimopoulos, Georges, Ali, Fadi, Papageorgiou, Eirini, Athanasa, Zoi, Sakagianni, Aikaterini, Chantziara, Vasiliki, Efthymiou, Anna, Georgopoulou, Maria, Chatzis, Marinos, Sakkalis, Anastasios, Nikolaou, Charikleia, Kogkopoulos, Evangelos, Oikonomou, Marina, Kampolis, C, Papanikolaou, M, Marmanidou, Kyriaki, Paskalis, Harry, Karaiskos, Ilias, Moldovan, Leora, Matei, Mariana Kristina, Koutsoukou, Vasiliki, Romanou, Vasiliki, Vasileiou, Maria, Renta, Foteini, Papoti, Sofia, Iasonidou, Cristina, Kaimakamis, Evangelos, Soulountsi, Vasiliki, Fildisis, Georgios, Psallida, Vasiliki, Smyrniotis, Dimitrios, Arvaniti, Kostoula, Temirov, Talgat, Merenkov, Yevgeniy, Babashev, Baurzhan, Kaligozhin, Zhannur, Bazhykayeva, Yelena, Mugazov, Miras, Ymbetzhanov, Yerlan, Viderman, Dmitriy, Metz, Carlos, Lepper, Philippe, Wempe, Carola, Gottschalk, Antje, Schmidt, Karsten, Dubler, Simon, Pasieka, Bastian, Petros, Sirak, Thomas-Rueddel, Daniel, Bloos, Frank, Hoheisen, Sandra, Bracht, Hendrik, Klouche, Kada, Imzi, Nadia, Dahyot-Fizelier, Claire, Fartoukh, Muriel, Voiriot, Guillaume, Aparicio, Christelle, Siami, Shidasp, Le Guennec, Loïc, Demeret, Sophie, Silva, Stein, Sarton, Benjamine, Roger, Claire, Lefrant, Jean-Yves, Larcher, Romaric, Badre, Gaëtan, Kalfon, Pierre, Razazi, Keyvan, Dessap, Armand Mekonted, Baudry, Thomas, Argaud, Laurent, Smonig, Roland, Louis, Guillaume, Bourenne, Jérémy, Gainnier, Marc, Barbier, François, Djanikian, Flora, Perrigault, Pierre-François, Foucrier, Arnaud, Janny, Sylvie, Weiss, Emmanuel, Bruel, Cédric, Tran, Marc, Philippart, François, Paulet, Rémi, Thyrault, Martial, Duprey, Matthieu, Garcon, Pierre, Mira, Jean-Paul, Le Souhaitier, Mathieu, Bortolotti, Perrine, Kipnis, Eric, Duburcq, Thibault, Coupez, Elisabeth, Souweine, Bertrand, Nica, Alexandru, Alfandari, Serge, Leroy, Olivier, Rosman, Jérémy, Mateu, Philippe, Escudier, Etienne, Guesdon, Charlotte, Massri, Alexandre, Beuzelin, M, Marchalot, A, Le Meur, Anthony, Auchabie, Johann, Castanera, Jérémy, Dulac, Thierry, Montravers, P, Zappela, N, Patrier, Juliette, Timsit, Jean-François, Arbelot, Charlotte, Leone, Marc, Lasic, Hrvoje, Nikolic, Mario, Sakan, Sanja, Persec, Jasminka, Brajkovic, Ana Vujaklija, Radonic, Radovan, Filipovic-Grcic, Ina, Custovic, Aida, Zlojutro, Biljana, Kovacevic, Pedja, Opdenacker, Godelive, De Waele, Elisabeth, Wittebole, Xavier, Serck, Nicolas, De Schryver, Nicolas, Misset, Benoît, Layos, Nathalie, Noel, Cindérella, Biston, Patrick, Haentjens, Lionel, Henin, Pierre, Mesland, Jean-Baptiste, Vanderhaeghen, Sofie F M, Bourgeois, Marc, Denys, Wouter, Hollevoet, Isabelle, De Waele, Jan, De Bus, Liesbet, Tomas, Ernesto Deloya, Perez-Nieto, Orlando R, Tejeda-Huezo, Brigitte, Sánchez-Hurtado, Luis, Ñamendys-Silva, Silvio A, Davalos-Alvarez, Adrian, Dominguez-Cherit, Jose G, Lomeli-Teran, Manuel, Villafuerte, Missael Vladimir Espinoza, Herrera, Mara Ocotlan Gonzalez, Aguilar, Candy Garcia, Leal, Jesús Nicolás Pantoja, Castillo, Roberto Alejandro, Hermosillo, Mariana, Romero-Gonzalez, Juan P, Reyes, Luis Felipe, Montefiore, Pablo, Nuccetelli, Yanina, Alonzo, Microbiologa Irene, Aparicio, Dra Marta, Segura, Matías, Fernández, Rubén, Lopez, Patricia Mabel, Acevedo, José Oscar, Morvillo, Lic Natalia, Centeno, Pablo, Sellami, Walid, Turki, Olfa, Bouaziz, Mounir, Bakr, Lubna, Al-Jadaan, Mohammad, Abu-Sayf, Natalia, Chaaban, Mohammad Karam, Aljabbary, Ahmed, Awad, Maher, Almekhlafi, Ghaleb A, Elrabi, Omar, Sallam, Hend, Nissar, Shaikh, Lance, Marcus, Karic, Edin, Elbuzidi, Abdurahaman, Hssain, Ali Ait, Jayyab, Mustafa Abu, Amro, Sarah, Belkhadir, Z, Ghannam, A, Hachimi, Abdelhamid, Younes, Oujidi, Housni, Brahim, Zeggwagh, Amine Ali, Dendane, Tarek, Wajdi, Maazouzi Ahmed, Mouhssine, Doumiri, Kanjaa, Nabil, Boukatta, Brahim, Seddiki, Rachid, Serghini, Issam, Hasan, Rabab Shaban Ben, Hasan, Hayat Ben, Jobran, Rania, Hdada, Aisha Khaled, Abousnina, Fathi A, Abdulwahed, Eman, Taher, Ahmed Sa, Bouhuwaish, Ahmad, Bilkhayr, Hala, Almiqlash, Bushray, Homaidan, Ahmed Gaber Sadik, AliAli, Almajdoub Mohammed, Aqeelah, Ahmed, Gamra, Marwa, Buimsaedah, Ahmad, Fares, Aya, Ibrahim, Rebecca, Abilama, Fayez, Diab, Adei, Harara, Belal, Levin, Phillip, Belman, Daniel, Rigler, Merav, Kagan, Ilya, Singer, Pierre, Ahmed, Abdullah Khudhur, Tabatabaei, Seyed Mohammad Nasirodin, Tajvidi, Ramin, Masjedi, Mansoor, Sarshad, Hakimeh, Sabetian, Golnar, Dabiri, Gholamreza, Aalinezhad, Fatemeh, Mahmoodpoor, Ata, Zargar, Mohammad Amin, Kiani, Arash, Amiri, Fereshteh, Javaherforoosh, Fatemeh, Baghbanian, Reza, Soltani, Farhad, Savaie, Mohsen, Ahmadi, Fatemeh, Kashipazha, Davood, Mehraban, Zahra, Borsi, Seyed Hamid, Ouhadian, Maryam, Zand, Farid, Hemead, Hanan M, Awad, Ahmed K, Elbadawy, Merihan A, Elsayed, Ahmed, Elmandouh, Omar, Aldhalia, Amer, Saber, Ahmed, Elbahnasawy, Mohamed, Mostafa, Tarek, Osman, Nermin, Barsoum, Mina, Elhadidy, Amr, Alsisi, Adel, Houfi, Ashraf El, Nadeem, Rashid, Chiewroongroj, Supattra, Apichatbutr, Yutthana, Wongsurakiat, Phunsup, Ku, Shih-Chi, Kuo, Li-Kuo, Hu, Ting-Yu, Cia, Cong-Tat, Chou, Nai-Kuan, Yeh, Yu Chang, Ng, Louis Xiang Long, Ng, Kangqi, Quah, Jessica Lishan, Lim, Jia Yan, Ong, Caroline Yu Ming, Li, Andrew Yunkai, Goh, Ken Junyang, Kwa, Andrea Lay Hoon, Lie, Sui An, Ng, Shin Yi, Goh, Qing Yuan, Lim, Sung Yoon, Park, Seung Yong, Park, Sunghoon, Lee, Sang-Min, Jeon, Kyeongman, Ali, Saedah, Mazlan, Mohd Zulfakar, Azman, Abd Hamid, Tong, Lee Kok, Noor, Zuraini Md, Rahman, Hamizah Bt Abdul, Fong, Kean Khang, Wong, Siong Ling Danny, Liew, Mun Thing, Visvalingam, Sheshendrasurian, Pheng, Lee See, Jamaluddin, Muhamad Fadhil Hadi, Hasan, M Shahnaz, Takaki, Shunsuke, Kato, Hideaki, Atobe, Kaori, Saito, Hiroki, Rinka, Hiroshi, Omori, Koichiro, Fujitani, Shigeki, Yoshida, Hideki, Nagashima, Michio, Mishima, Yuka, Shigemitsu, Hidenobu, Kuriyama, Akira, Matsuyoshi, Takeo, Makino, Jun, Hosokawa, Koji, Hashimoto, Satoru, Yamasaki, Masaki, Karumai, Toshiyuki, Hayashi, Yoshiro, Geng, Nan, Peije, Li, Weifeng, Xie, Ye, Ling, Qin, Bingyu, Wang, Yan, Yan, Jing, Huang, Min, Zhou, Suming, Hu, Chungfang, Ye, Jilu, Zhang, Min, Yin, Yongjie, Wang, Jinfeng, Wang, Ruilan, Yin, Chengfen, Xu, Lei, Mingmin, Chen, Wusi, Qiu, Zhao, Juan, Zhao, Peng, Wang, Hao, Chen, Xiaomei, Luo, Jili, Qian, Chuanyun, Zhen, Wang, Wei-Hua, Lu, Jianfeng, Xie, Haibo, Qiu, Sridharan, Dhadappa Damodar, Sudhirchandra, Shah, Moorthi, P Dhakshina, Mon, Tomas, Walid, Haji Adi Muhamad Ibnu, Tabah, Alexis, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Conway Morris, Andrew, Bassetti, Matteo, Lipman, Jeffrey, Ferrer, Ricard, Qiu, Haibo, Paiva, José-Artur, Povoa, Pedro, Abidi, Khalid, Elhadi, Muhammed, Pollock, Hamish, Margetts, Ben, Young, Meredith, Bhadange, Neeraj, Tyler, Steven, Ledtischke, Anne, Finnis, Mackenzie, Dwivedi, Jyotsna, Saxena, Manoj, Biradar, Vishwanath, Soar, Natalie, Sarode, Vineet, Brewster, David, Regli, Adrian, Weeda, Elizabeth, Ahmed, Samiul, Fourie, Cheryl, Laupland, Kevin, Ramanan, Mahesh, Walsham, James, Meyer, Jason, Litton, Edward, Palermo, Anna Maria, Yap, Timothy, Eroglu, Ege, Attokaran, Antony George, Jaramillo, C'havala, Nafees, Khalid Mahmood Khan, Rashid, Nurhikmahtul Aqilah Haji Abd, Tabah, Alexi, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Conway Morris, Andrew, Bassetti, Matteo, Arvaniti, Kostoula, Lipman, Jeffrey, Ferrer, Ricard, Qiu, Haibo, Paiva, José-Artur, Povoa, Pedro, De Bus, Liesbet, De Waele, Jan, Zand, Farid, Gurjar, Mohan, Alsisi, Adel, Abidi, Khalid, Bracht, Hendrik, Hayashi, Yoshiro, Jeon, Kyeongman, Elhadi, Muhammed, Barbier, Françoi, Timsit, Jean-Françoi, EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network including, Andrea Cortegiani, and Mariachiara Ippolito

Subjects
antibiotic resistance, bloodstream infection, hospital-acquired, bacteremia, Critical Care and Intensive Care Medicine
Abstract

Purpose: In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods: We carried out a prospective international cohort study of adult patients (≥ 18years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results: 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) waspresent in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alivefrom hospital by day-28. Conclusions: HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes.

Published
2023

14. Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study)

Author

Pascale, Renato, primary, Toschi, Alice, additional, Aslan, Abdullah Tarik, additional, Massaro, Giulia, additional, Maccaro, Angelo, additional, Fabbricatore, Davide, additional, Dell'Aquila, Andrea, additional, Ripa, Marco, additional, Işık, Mehmet Emirhan, additional, Kızmaz, Yeşim Uygun, additional, Iacopino, Saverio, additional, Camici, Marta, additional, Perna, Francesco, additional, Akinosoglou, Karolina, additional, Karruli, Arta, additional, Papadimitriou-Olivgeris, Matthaios, additional, Kayaaslan, Bircan, additional, Bilir, Yeşim Aybar, additional, Evren Özcan, Emin, additional, Turan, Oğuzhan Ekrem, additional, Işık, Muhammed Cihan, additional, Pérez-Rodríguez, María Teresa, additional, Yagüe, Belén Loeches, additional, Quirós, Alejandro Martín, additional, Yılmaz, Mesut, additional, Petersdorf, Sabine, additional, De Potter, Tom, additional, Durante-Mangoni, Emanuele, additional, Akova, Murat, additional, Curnis, Antonio, additional, Gibertoni, Dino, additional, Diemberger, Igor, additional, Scudeller, Luigia, additional, Viale, Pierluigi, additional, Giannella, Maddalena, additional, Caroccia, Natascia, additional, Fanì, Francesca, additional, Arbizzani, Federica, additional, Ramanathan, Ramsiya, additional, Scarpellini, Paolo, additional, Marzi, Alessandra, additional, Mazzone, Patrizio, additional, Placentino, Filippo, additional, Sammarini, Giulia, additional, Tenti, Elena, additional, Leventopulos, George, additional, Domenichini, Giulia, additional, Şahin, Meyha, additional, Suárez-Varela, Milagros, additional, and Villegas, Elkin González, additional

Published
2023
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15. Sepsis Care, Diagnostics and Quality Management: A Multidisciplinary Cross-Sectional Survey in 73 Countries

Author

Scheer, Christian S., primary, Giamarellos-Bourboulis, Evangelos, additional, Ferrer, Ricard, additional, Idelevich, Evgeny A., additional, Annane, Djillali, additional, Artigas, Antonio, additional, Aslan, Abdullah Tarik, additional, Baltaga, Ruslan, additional, Bottari, Gabriella, additional, Bouma, Hjalmar R., additional, Černý, Vladimir, additional, Radivojević, Renata Curić, additional, Dewitte, Ken, additional, Elbahnasawy, Mohamed, additional, Gründling, Matthias, additional, Gurjar, Mohan, additional, Hästbacka, Johanna, additional, Laribi, Said, additional, Lassen, Annmarie, additional, Lebedinskii, Konstantin, additional, Máca, Jan, additional, Malbrain, Manu L.N.G., additional, Monti, Gianpaola, additional, Ostermann, Marlies, additional, Osthoff, Michael, additional, Paiva, Jose-Artur, additional, Sabbatucci, Michela, additional, Śmiechowicz, Jakub, additional, Ştefan, Mihai Gabriel, additional, Vollmer, Marcus, additional, Vukovic, Natalija, additional, Zaragkoulias, Kyriakos, additional, Reinhart, Konrad, additional, Linder, Adam, additional, Filipescu, Daniela, additional, and Group, European Sepsis Care Study, additional

Published
2023
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17. Variation in communication and family visiting policies in intensive care within and between countries during the Covid-19 pandemic: The COVISIT international survey

Author

Tabah, Alexis, primary, Elhadi, Muhammed, additional, Ballard, Emma, additional, Cortegiani, Andrea, additional, Cecconi, Maurizio, additional, Unoki, Takeshi, additional, Galarza, Laurą, additional, Rosa, Regis Goulart, additional, Barbier, Francois, additional, Azoulay, Elie, additional, Laupland, Kevin B., additional, Kai, Nathalie Ssi Yan, additional, Ostermann, Marlies, additional, Francois, Guy, additional, De Waele, Jan J., additional, Fiest, Kirsten, additional, Spronk, Peter, additional, Benbenishty, Julie, additional, Pellegrini, Mariangela, additional, Rose, Louise, additional, Ramanan, Mahesh, additional, Bailey, Rachel, additional, Kronberger, Irmgard E., additional, Cerovac, Anis, additional, Sligl, Wendy, additional, Peršec, Jasminka, additional, Lincango-Naranjo, Eddy, additional, Osman, Nermin, additional, Tanas, Yousef, additional, Dean, Yomna, additional, Abbas, Ahmed Mohamed, additional, Elbahnasawy, Mohamed Gamal, additional, Elshennawy, Eslam Mohamed, additional, Elmandouh, Omar, additional, Ahmed, Fatima Hamed, additional, Koulenti, Despoina, additional, Tsakiridis, Ioannis, additional, Gurjar, Mohan, additional, Cindryani, Marilaeta, additional, Mahmoodpoor, Ata, additional, Aldawoody, Hogir Imad Rasheed, additional, Zuccaro, Francesco, additional, Iozzo, Pasquale, additional, Ippolito, Mariachiara, additional, Katayama, Yukiko, additional, Kuribara, Tomoki, additional, Miyazaki, Satoko, additional, Nakayama, Asami, additional, Ouchi, Akira, additional, Sakuramoto, Hideaki, additional, Tamoto, Mitsuhiro, additional, Yamada, Toru, additional, Serhan, Hashem Abdulaziz Abu, additional, Alsakarneh, Saqr Ghaleb Ghassab, additional, Kaligozhin, Zhannur, additional, Viderman, Dmitriy, additional, Karout, Lina, additional, Hasan, Mohd Shahnaz, additional, Zakaria, Andee Dzulkarnaen, additional, Ñamendys-Silva, Silvio A., additional, Rai, Lajpat, additional, Abello, Antonio Thaddeus R., additional, Povoa, Pedro, additional, Tomescu, Dana, additional, Drozdov, Evgeniy, additional, Gallego, Alberto Orejas, additional, Jariod-Ferrer, Ursula M., additional, Nuñez-Garçia, Bernardo, additional, Mohamed, Ahmed Mohamed Ibrahim, additional, George, Abram Raymon Moneer, additional, Jeitziner, Marie-Madlen, additional, Saracoglu, Kemal Tolga, additional, Isik, Arda, additional, Aslan, Abdullah Tarik, additional, and Torlinski, Tomasz, additional

Published
2022
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18. O1143 Turkish prospective study on carbapenem-resistant Klebsiella pneumoniae bacteraemia: preliminary results

Author

Isler, Burcu, Gule Aydin, Aslan, Abdullah Tarik, Demirkaya, Melike Hamiyet, Tulek, Necla, Inanc Balkan, Sirin Menekse Yilmaz, Siran Keske, Vatansever, Cansel, Ozer, Berna, Ozlem Dogan, Simsek, Funda, Gülsen Hazirolan, Yagci, Serap, Cigdem Arabaci, Gönen, Mehmet, Nese Saltoglu, Azap, Kurt, Azap, Alpay, Akova, Murat, Fusun Can, and Ergönül, Önder

Published
2020
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20. Mild to moderate proteinuria is a heralding sign for acute kidney injury and mortality for intensive care unit patients

Author

YETER, Haci Hasan, YILDIRIM, Tolga, EYÜPOĞLU, Nesrin Damla, PASAYEV, Tural, ASLAN, Abdullah Tarik, ÇETİK, Sila, AKÇAY, Ömer Faruk, İSKİT, Arzu Topeli, and ARICI, Mustafa

Subjects
urogenital system, urologic and male genital diseases, Acute kidney injury,urine dipstick protein,proteinuria,28-day mortality
Abstract

Background/aim: Lack of early predictors of acute kidney injury is currently delaying timely diagnosis.This study was done to evaluate the relationship between mild to moderate proteinuria and incidence of acute kidney injury (AKI) and 28-day mortality in intensive care unit (ICU) patients. Material and methods: This observational, retrospective study was conducted in the internal medicine ICU. A total of 796 patients were screened and 525 patients were used for this analysis. Proteinuria was measured by urine dipstick test. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Results: Patients with dipstick urine protein positivity on admission had higher proportion of AKI and 28-day mortality compared to dipstick urine protein negative group [164 (59.6%) vs. 111 (44.4%) and 101 (36.7%) vs. 54 (21.6%), P = 0.01 and P < 0.01, respectively]. Urine dipstick protein positivity was also a significant predictor of 28-day mortality in patients with GFR > 60 mL/min (hazard ratio: 1.988, 95% confidence interval 1.380-2.862). Conclusion: Proteinuria before ICU admission is a risk factor for development of AKI within seven days of ICU stay and also is a risk factor for 28-day mortality, even in patients with GFR > 60 mL/min.

Published
2019

21. Comparison of 30-day crude mortality rates of different antibiotic therapies and identification of independent risk factors for 30-day crude mortality in bloodstream infections with non-KPC carbapenemase producing Klebsiella pneumoniae: Importance of appropriate therapy and combination therapy

Author

Aslan, Abdullah Tarik, Akova, Murat, Sain Güven, Gülay, and İç Hastalıkları Anabilim Dalı

Subjects
Carbapenemase, Klebsiella pneumoniae, Blood, Antibiotics, Hematologic diseases, Mortality, Infection, Medical Biology, Tıbbi Biyoloji, Klebsiella Infections
Abstract

ÖzetGiriş. Karbapenemaz üreten Klebsiella Pneumoniae infeksiyonları, özellikle 0XA-48 karbapenemaz pozitif olanlar için en uygun antibiyotik tedavisi net olarak belirlenmemiştir. Biz bu bakteriler nedeniyle oluşan kan akımı infeksiyonlarının (KAİ) 30 günlük kaba mortalite oranlarını farklı antibiyotik rejimleri için kıyasladık. Yöntem. Bu çalışma 01.01.2014 ile 31.07.2018 tarihleri arasında tedavi edilen bütün KPC dışı KÜKp KAİ olan hastaları içeren retrospektif kohort çalışmadır. Antibiyotik tedavisi eğer kan akımı infeksiyonunun başlangıcının ilk beş gün içinde başlanmış, uygun dozda en az bir aktif antibiyotik içeriyorsa uygundu. Bakteri tanımlaması otomatize sistemlerle yapıldı ve in-vitro duyarlılık testleri EUCAST sınır değerleri ile değerlendirildi. Karbapenemler ve diğer antibiyotiklerin MIK değerleri E-test ile doğrulandı. Kolistin MIK değerleri broth mikrodilusyon ile tespit edildi. Tigesiklin MIC değerleri US FDA kriterlerine göre değerlendirildi. Karbapenemaz genlerinin (blaKPC, blaNDM, blaVIM, blaOXA-48.) moleküler tespiti polimeraz zincir reaksiyonu (PZR) ile yapıldı.Bulgular. Çalışma süreci boyunca tespit edilen 174 KÜKp KAİ içinden, 129 hasta bütün dahil edilme kriterlerini karşılıyordu. Antibiyotik duyarlılık sonuçları aşağıdaki gibiydi: Kolistin (%51.9), Tigesiklin (%67.4), Gentamisin (%38.0), Amikasin (%43.0), Meropenem (%32.6), Ertapenem (%3.1), Siprofloksasin (%18.6), Trimethoprim-sulfametaksazol (%24.0), Seftazidim (%7.8), Sefepim (%7.8) ve Seftriakson (%7.0). İzolatların %85.3 ve %3.1'i sırasıyla OXA-48 ve NDM genleri içeriyordu. Ayrıca, izolatların %9.3'ü OXA-48 ve NDM genlerini birlikte taşıyordu ve izolatların %2.3'ü OXA-48 ve VIM genlerini birlikte kodluyordu. Uygunsuz tedavi uygun tedaviye kıyasla daha yüksek 30 günlük mortalite oranıyla ilişkiliydi (ayarlanmış OR: 4.29; 95% CI, 1.77-10.39; p=0.001). Ancak, monoterapi ve kombinasyon tedavi kollarında 30 günlük kaba mortalite oranları açısından anlamlı bir fark yoktu (ayarlanmış OR: 2.2; 95% CI, 0.45-10.6; P=0.32). Çoklu değişkenli lojistik regresyon analizinde, Increment mortalite skoru (ayarlanmış OR: 1.27; 95% CI, 1.14-1.42; P

Published
2019

25. 2277. Comparison of 30-day Crude Mortality Rates in Patients with Bloodstream Infections (BSIs) Caused by Colistin Susceptible-(ColS-CRKp) vs. Colistin and Carbapenem-Resistant Klebsiella pneumoniae(ColR-CRKp).

Author

Aslan, Abdullah Tarik, Bıçakçıgil, Asiye, Gürsoy, Nafia Canan, Liste, Ümran, Tozluyurt, Abdullah, Otlu, Barış, Sancak, Banu, Dağ, Osman, Güven, Gülay Sain, and Akova, Murat

Subjects
*KLEBSIELLA pneumoniae, *COLISTIN, *CEFTAZIDIME, *DRUG resistance in bacteria, *LOGISTIC regression analysis, *DRUG dosage, *MORTALITY
Abstract

Background Colistin is a last resort antibiotic against infections with CRKp. Its increased use has led to resistance to this antibiotic. Methods This was a single-center, retrospective, cohort study including all CRKp BSIs treated between January 1, 2014 and July 31, 2018. Antibiotic therapy was appropriate if initiated within 5 days from the onset of BSI including at least an active drug with an adequate dosage. Exclusion criteria were missing key data, death < 24 h after inclusion, subsequent episodes in the same patients, pregnancy, polymicrobial BSI, < 18 years of age, no ID consultation, no carbapenemase gene detection by multiplex PCR for blaKPC, blaNDM, blaVIM, blaIMPand blaOXA48. EUCAST breakpoints were used for antibiotic susceptibilities. Colistin MIC was determined by using broth microdilution. FDA criteria were applied for tigecycline susceptibility Results Among 174 CRKp BSIs, 129 met all inclusion criteria. Susceptibility to antibiotics was as follows: colistin (51.9%), tigecycline (67.4%), gentamicine (38.0%), amikacin (43.0%), meropenem (32.6%), ciprofloxacin (18.6%), TMP-SMX (24.0%), ceftazidime (7.8%), cefepime (7.8%). 66.1% and 19.4% of the patients received inappropriate therapy in ColR-CRKp and ColS-CRKp groups, respectively (P ≤ 0.001). We incorporated interaction between colistin susceptibility and inappropriate therapy into multivariate logistic regression analysis (MLRA) that was constructed for identification of independent risk factors for 30-day mortality. The variables having P ≤ 0.1 in crude analysis were included in MLRA. After checking correlation between variables by Pearson correlation analysis and multicollinearity analysis, the final model was builded. The results are shown in Table 2. Conclusion Colistin resistance and inappropriate therapy were not associated with decreased mortality individually, however their interaction significantly increased 30-day mortality rate (OR: 4.04; 95% CI: 1.62–10.02; P = 0.003).85.5% of ColR-CRKp isolates produced an OXA-48 enzyme which can be inhibited by ceftazidime–avibactam, but not available in our setting, treatment with this agent may have altered the mortality rates. Thus, high rate colistin resistance among CRKp isolates remains as a significant cause of mortality in our setting. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]

Published
2019
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26. Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicenter observational study (CarDINe Study)

Author

Renato Pascale, Alice Toschi, Abdullah Tarik Aslan, Giulia Massaro, Angelo Maccaro, Davide Fabbricatore, Andrea Dell'Aquila, Marco Ripa, Mehmet Emirhan Işık, Yeşim Uygun Kızmaz, Saverio Iacopino, Marta Camici, Francesco Perna, Karolina Akinosoglou, Arta Karruli, Matthaios Papadimitriou-Olivgeris, Bircan Kayaaslan, Yeşim Aybar Bilir, Emin Evren Özcan, Oğuzhan Ekrem Turan, Muhammed Cihan Işık, María Teresa Pérez-Rodríguez, Belén Loeches Yagüe, Alejandro Martín Quirós, Mesut Yılmaz, Sabine Petersdorf, Tom De Potter, Emanuele Durante-Mangoni, Murat Akova, Antonio Curnis, Dino Gibertoni, Igor Diemberger, Luigia Scudeller, Pierluigi Viale, Maddalena Giannella, Natascia Caroccia, Francesca Fanì, Federica Arbizzani, Ramsiya Ramanathan, Paolo Scarpellini, Alessandra Marzi, Patrizio Mazzone, Filippo Placentino, Giulia Sammarini, Elena Tenti, George Leventopulos, Giulia Domenichini, Meyha Şahin, Milagros Suárez-Varela, Elkin González Villegas, Pascale, Renato, Toschi, Alice, Aslan, Abdullah Tarik, Massaro, Giulia, Maccaro, Angelo, Fabbricatore, Davide, Dell'Aquila, Andrea, Ripa, Marco, Işık, Mehmet Emirhan, Kızmaz, Yeşim Uygun, Iacopino, Saverio, Camici, Marta, Perna, Francesco, Akinosoglou, Karolina, Karruli, Arta, Papadimitriou-Olivgeris, Matthaio, Kayaaslan, Bircan, Bilir, Yeşim Aybar, Evren Özcan, Emin, Turan, Oğuzhan Ekrem, Işık, Muhammed Cihan, Pérez-Rodríguez, María Teresa, Yagüe, Belén Loeche, Quirós, Alejandro Martín, Yılmaz, Mesut, Petersdorf, Sabine, De Potter, Tom, Mangoni, Emanuele Durante, Akova, Murat, Curnis, Antonio, Gibertoni, Dino, Diemberger, Igor, Scudeller, Luigia, Viale, Pierluigi, and Giannella, Maddalena

Subjects
Microbiology (medical), endocarditi, Infectious Diseases, cardiovascular implantable electronic device, CIED infection, FDG PET/CT, cardiovascular implantable electronic devices, endocarditis, gram-negative, Pharmacology (medical), General Medicine
Abstract

Background: Infections of cardiovascular implantable electronic devices (CIED) are mainly due to Gram-positive bacteria (GPB). Data about Gram-negative bacteria CIED (GNB-CIED) infections are limited. This study aimed to investigate risk factors, clinical and diagnostic characteristics, and outcome of patients with GNB-CIED. Methods: A multicentre, international, retrospective, case-control-control study was performed on patients undergoing CIED implantation from 2015 to 2019 in 17 centres across Europe. For each patient diagnosed with GNB-CIED, one matching control with GPB-CIED infection and two matching controls without infection were selected. Results: A total of 236 patients were enrolled: 59 with GNB-CIED infection, 59 with GPB-CIED infection and 118 without infection. No between-group differences were found regarding clinical presentation, diagnostic and therapeutic management. A trend toward a higher rate of fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) positivity was observed among patients with GNB than in those with GPB-CIED infection (85.7% vs. 66.7%; P = 0.208). Risk factors for GNB-CIED infection were Charlson Comorbidity Index Score (relative risk reduction, RRR = 1.211; P = 0.011), obesity (RRR = 5.122; P = 0.008), ventricular-pacing ventricular-sensing inhibited-response pacemaker implantation (RRR = 3.027; P = 0.006) and right subclavian vein site of implantation (RRR = 5.014; P = 0.004). At 180-day survival analysis, GNB-CIED infection was associated with increased mortality risk (HR = 1.842; P = 0.067). Conclusions: Obesity, high number of comorbidities and right subclavian vein implantation site were associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided using FDG PET/CT is suggested in patients with GNB-CIED infection, considering the poorer outcome observed in this group.

Published
2023

27. The heterogeneous syndrome of non-infectious causes of persistent fever in neutropenic patients with hematologic malignancy: another opportunity for stewardship?

Author

Aslan AT, Akova M, and Kontoyiannis DP

Abstract

Although occult fungal, viral and multidrug-resistant bacterial infections can cause persistent fever in neutropenic patients with hematologic cancer, a variety of non-infectious entities should be considered in case-by-case basis in the context of negative diagnostic workup for infection., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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