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1. Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease.

Author

Gangaputra, Sapna, Newcomb, Craig, Armour, Rebecca, Dongseok Choi, Gui-shuang Ying, Groth, Sylvia, Begum, Hosne, Fitzgerald, Tonetta, Pichaporn Artornsombudh, Daniel, Ebenezer, Bhatt, Nirali, Foster, Stephen, Jabs, Douglas, Levy-Clarke, Grace, Nussenblatt, Robert, Rosenbaum, James T., Sen, H. Nida, Suhler, Eric, Thorne, Jennifer, and Dreger, Kurt

Abstract

Purpose To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease. Setting Tertiary care academic centres. Design Multicentre retrospective cohort study. Methods A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was used to gather clinical data. Multivariable logistic regression models with adjustment for intereye correlations were performed to evaluate the prognostic factors for VA outcomes. Main outcome measure was VA after cataract surgery. Results Uveitic eyes independent of anatomical location showed improved VA from baseline (mean 20/200) to within 3 months (mean 20/63) of cataract surgery and maintained through at least 5 years of follow-up (mean 20/63). Eyes that achieved 20/40 or better VA at 1 year were more likely to have scleritis (OR=1.34, p<0.0001) or anterior uveitis (OR=2.2, p<0.0001), VA 20/50 to 20/80 (OR 4.76 as compared with worse than 20/200, p<0.0001) preoperatively, inactive uveitis (OR=1.49, p=0.03), have undergone phacoemulsification (OR=1.45 as compared with extracapsular cataract extraction, p=0.04) or have had intraocular lens placement (OR=2.13, p=0.01). Adults had better VA immediately after surgery, with only 39% (57/146) paediatric eyes at 20/40 or better at 1 year. Conclusions Our results suggest that adult and paediatric eyes with uveitis typically have improved VA following cataract surgery and remain stable thereafter for at least 5 years. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease

Author

Gangaputra, Sapna, primary, Newcomb, Craig, additional, Armour, Rebecca, additional, Choi, Dongseok, additional, Ying, Gui-shuang, additional, Groth, Sylvia, additional, Begum, Hosne, additional, Fitzgerald, Tonetta, additional, Artornsombudh, Pichaporn, additional, Daniel, Ebenezer, additional, Bhatt, Nirali, additional, Foster, Stephen, additional, Jabs, Douglas, additional, Levy-Clarke, Grace, additional, Nussenblatt, Robert, additional, Rosenbaum, James T, additional, Sen, H Nida, additional, Suhler, Eric, additional, Thorne, Jennifer, additional, Dreger, Kurt, additional, Buchanich, Jeanine, additional, and Kempen, John H, additional

Published
2023
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3. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

Author

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Kraus, Martin F., Fujimoto, James G., Jia, Yali, Wei, Eric, Wang, Xiaogang, Zhang, Xinbo, Morrison, John C., Parikh, Mansi, Lombardi, Lori H., Gattey, Devin M., Armour, Rebecca L., Edmunds, Beth, Huang, David, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Kraus, Martin F., Fujimoto, James G., Jia, Yali, Wei, Eric, Wang, Xiaogang, Zhang, Xinbo, Morrison, John C., Parikh, Mansi, Lombardi, Lori H., Gattey, Devin M., Armour, Rebecca L., Edmunds, Beth, and Huang, David

Abstract

Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used to evaluate cup/disc (C/D) ratios. Wide-field OCT scans over the discs were used to measure retinal nerve fiber layer (NFL) thickness. Main Outcome Measures Variability was assessed by coefficient of variation (CV). Diagnostic accuracy was assessed by sensitivity and specificity. Comparisons between glaucoma and normal groups were analyzed by Wilcoxon rank-sum test. Correlations among disc flow index, structural assessments, and visual field (VF) parameters were assessed by linear regression. Results In normal discs, a dense microvascular network was visible on OCT angiography. This network was visibly attenuated in subjects with glaucoma. The intra-visit repeatability, inter-visit reproducibility, and normal population variability of the optic disc flow index were 1.2%, 4.2%, and 5.0% CV, respectively. The disc flow index was reduced by 25% in the glaucoma group (P = 0.003). Sensitivity and specificity were both 100% using an optimized cutoff. The flow index was highly correlated with VF pattern standard deviation (R[superscript 2] = 0.752, P = 0.001). These correlations were significant even after accounting for age, C/D area ratio, NFL, and rim area. Conclusions Optical coherence tomography angiography, generated by the new SSADA, repeata, National Institutes of Health (U.S.) (Grant 1R01 EY023285-01), Rosenbaum's P30EY010572, National Institutes of Health (U.S.). Clinical and Translational Science Awards (CTSA) Program (Grant UL1TR000128), Research to Prevent Blindness, Inc. (United States) (Grant R01-EY11289-26), United States. Air Force Office of Scientific Research (FA9550-10-1-0551), German Research Foundation (DFG-HO-1791/11-1), German Research Foundation (DFG-GSC80-SAOT), German Research Foundation (Training Group 1773)

Published
2015

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