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Your search keyword '"Arkhipova, Valentina A."' showing total 24 results
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24 results on '"Arkhipova, Valentina A."'

7. Assessment of the influence of social factors on reproduction of personnel potential in agriculture of Russia

Author

Orlov Viktor, Ivanova Tatyana, Arkhipova Valentina, and Ivanitskaya Iraida

Subjects
Environmental sciences, GE1-350
Abstract

Based on the results of the PEST-analysis and methodological tools for determining the motives for the potential turnover of staff from agriculture, the dependence of the reproduction of personnel potential on social factors was revealed. Using the method of index analysis, the article developed a method for calculating the integral indicator of changes in social conditions in agriculture. Further, using the tools of mathematical modeling, its effect on the reproduction of personnel potential in the industry was proved.

Published
2019
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10. Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits

Author

Smith, Christopher R., primary, Kulyk, Svitlana, additional, Ahmad, Misbha Ud Din, additional, Arkhipova, Valentina, additional, Christensen, James G., additional, Gunn, Robin J., additional, Ivetac, Anthony, additional, Ketcham, John M., additional, Kuehler, Jon, additional, Lawson, J. David, additional, Thomas, Nicole C., additional, Wang, Xiaolun, additional, and Marx, Matthew A., additional

Published
2022
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11. Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue

Author

Arkhipova, Valentina, primary, Fu, Haigen, additional, Hoorens, Mark W. H., additional, Trinco, Gianluca, additional, Lameijer, Lucien N., additional, Marin, Egor, additional, Feringa, Ben L., additional, Poelarends, Gerrit J., additional, Szymanski, Wiktor, additional, Slotboom, Dirk J., additional, and Guskov, Albert, additional

Published
2021
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16. Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hitsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00163b

Author

Smith, Christopher R., Kulyk, Svitlana, Ahmad, Misbha Ud Din, Arkhipova, Valentina, Christensen, James G., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, Lawson, J. David, Thomas, Nicole C., Wang, Xiaolun, and Marx, Matthew A.

Abstract

Here we describe the early stages of a fragment-based lead discovery (FBLD) project for a recently elucidated synthetic lethal target, the PRMT5/MTA complex, for the treatment of MTAP-deleted cancers. Starting with five fragment/PRMT5/MTA X-ray co-crystal structures, we employed a two-phase fragment elaboration process encompassing optimization of fragment hits and subsequent fragment growth to increase potency, assess synthetic tractability, and enable structure-based drug design. Two lead series were identified, one of which led to the discovery of the clinical candidate MRTX1719.

Published
2022
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17. Features of student virtual social capital: Characteristics, opportunities and limits.

Author

Arkhipova, Valentina A., Vasilyeva, Larisa G., Gurdzhiyan, Vladimir L., Makarov, Alexandr L., Mashkin, Nikolay A., Nikitina, Anna A., and Magaramov, Sharafetdin A.

Subjects
*SOCIAL capital, *SOCIAL networks, *KNOWLEDGE transfer, *COMMUNICATION, *STUDENTS
Abstract

The relevance of this article lies in the need to study the possibilities of accumulating virtual social capital, maintaining it with the help of virtual social networks and using it in the educational, labor and leisure spheres. Since such resources can make a significant contribution to any area of a person's life: assistance in the field of education, and significant bonuses for employment. The purpose of the study is to identify mechanisms for acquiring, preserving and strengthening virtual social capital. Research methods: as a research method, a questionnaire survey was used to describe and analyze the features of using virtual social networks in the educational, labor and leisure spheres of users' lives. Research results: the article considers the features of virtual social capital formation. The novelty and originality of the research lies in the fact that for the first time students' idea of virtual social capital is considered. It is shown that virtual social networks are very popular with students. The factors that encourage users of virtual social networks to use their capabilities in solving significant issues in each of the studied areas are identified. It is determined that the social network is used mainly as a means of communication and information transfer, as well as a tool for organizing leisure, goals pursued in the educational sphere, in the field of career and leisure can be no less successfully implemented with its help. It is revealed that undergraduate students do not consider study groups in social networks to be effective, while master's students consider such groups effective. It is shown that it is more difficult to accumulate virtual social capital in the labor sphere than in the educational sphere, since this is due to the closeness of working groups and low career mobility of employees. It is determined that for the formation of virtual social capital in the labor sphere it is necessary firstly to find good real contacts. It is shown that it is necessary to form virtual social capital in the labor sphere depending on the type of work: if the work is in the classical sphere, then personal acquaintances and further real communication will be better suited here, and if the work is in the innovative sphere, it is better to build and maintain relationships in the virtual space. It is revealed that the use of social networks in the field of leisure is the most popular for the formation of virtual social capital. Practical significance: the data obtained in this work can be used in social psychology, labor psychology, management, as well as for further theoretical development of this issue. [ABSTRACT FROM AUTHOR]

Published
2020

23. Four translation initiation pathways employed by the leaderless mRNA in eukaryotes

Author

Akulich, Kseniya A., primary, Andreev, Dmitry E., additional, Terenin, Ilya M., additional, Smirnova, Victoria V., additional, Anisimova, Aleksandra S., additional, Makeeva, Desislava S., additional, Arkhipova, Valentina I., additional, Stolboushkina, Elena A., additional, Garber, Maria B., additional, Prokofjeva, Maria M., additional, Spirin, Pavel V., additional, Prassolov, Vladimir S., additional, Shatsky, Ivan N., additional, and Dmitriev, Sergey E., additional

Published
2016
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