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21 results on '"Aoki, Katsuyuki"'

9. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix

Author

Matsumoto, Takashi, primary, Takiyama, Mikina, additional, Sanechika, Shou, additional, Nakayama, Akiko, additional, Aoki, Katsuyuki, additional, Ohbuchi, Katsuya, additional, Kushida, Hirotaka, additional, Kanno, Hitomi, additional, Nishi, Akinori, additional, and Watanabe, Junko, additional

Published
2020
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10. Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β‐glucuronidase in macrophages

Author

Kaneko, Atsushi, Matsumoto, Takashi, Matsubara, Yosuke, Sekiguchi, Kyoji, Koseki, Junichi, Yakabe, Ryo, Aoki, Katsuyuki, Aiba, Setsuya, and Yamasaki, Kenshi

Subjects
Flavonoids, Mice, Mice, Inbred ICR, Staphylococcus aureus, Glucuronides, β‐glucuronidase, Macrophages, Animals, Staphylococcal Skin Infections, Phytoestrogens, Original Research, estrogen receptor, Glucuronidase
Abstract

Introduction Flavonoids are converted to inactive metabolites like glucuronides in the gut, and circulate mainly as glucuronides in blood stream, resulting in low concentrations of active aglycones in plasma. It is therefore unclear how oral flavonoids exert their effects in tissues. We recently reported the plasma pharmacokinetics of some flavonoids and suggested the possibility that the absorbed flavonoids modified macrophage functions leading to enhance bacterial clearance. We aimed to confirm their pharmacological profiles focusing on tissue macrophages. Methods Pseudoinfection was induced by intradermal injection of FITC‐conjugated and killed Staphylococcus aureus into the ears of mice treated with or without genistein 7‐O‐glucuronide (GEN7G, 1 mg/kg, i.v.). FACS analysis was performed on single cell suspensions dispersed enzymatically from the skin lesions at 6 h post pseudoinfection to evaluate phagocytic activities of monocytes/macrophages (CD11b+Ly6G−) and neutrophils (CD11b+Ly6G+). Phagocytosis of the FITC‐conjugated bacteria by four glucuronides including GEN7G was evaluated in cultures of mouse macrophages. Results After GEN7G injection, genistein was identified in the inflamed ears as well as GEN7G, and the phagocytic activity of CD11b+Ly6G− cells was increased. GEN7G was converted to genistein by incubation with macrophage‐related β‐glucuronidase. Macrophage culture assays revealed that GEN7G increased phagocytosis, and the action was dampened by a β‐glucuronidase inhibitor. Binding of aglycones to estrogen receptors (ERs), putative receptors of flavonoid aglycones, correlated to biological activities, and glucuronidation reduced the binding to ERs. An ER antagonist suppressed the increase of macrophage function by GEN7G, whereas estradiol enhanced phagocytosis as well. Conclusions This study suggests a molecular mechanism by which oral flavonoids are carried as glucuronides and activated to aglycones by β‐glucuronidase in tissue macrophages, and contributes to the pharmacological study of glucuronides.

Published
2017

14. Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study

Author

Kitagawa, Hiroyuki, primary, Munekage, Masaya, additional, Matsumoto, Takashi, additional, Sadakane, Chiharu, additional, Fukutake, Miwako, additional, Aoki, Katsuyuki, additional, Watanabe, Junko, additional, Maemura, Kazuya, additional, Hattori, Tomohisa, additional, Kase, Yosio, additional, Uezono, Yasuhito, additional, Inui, Akio, additional, and Hanazaki, Kazuhiro, additional

Published
2015
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16. Patent Issued for High Thermal Conductive Silicon Nitride Sintered Body, And Silicon Nitride Substrate And Silicon Nitride Circuit Board And Semiconductor Apparatus Using The Same (USPTO 10,308,560)

Subjects
Printed circuit boards -- Reports -- Intellectual property, Sintering -- Reports, Silicon -- Reports -- Intellectual property, Nitrides -- Reports -- Intellectual property, Silicon compounds -- Reports -- Intellectual property, Editors, Printed circuit board, Electronics
Abstract

2019 JUN 18 (VerticalNews) -- By a News Reporter-Staff News Editor at Electronics Newsweekly -- From Alexandria, Virginia, VerticalNews journalists report that a patent by the inventor Aoki, Katsuyuki (Kanagawa, [...]

Published
2019

17. Cinema of Discontent : Representations of Japan's High-Speed Growth

Author

Tomoyuki Sasaki and Tomoyuki Sasaki

Subjects
Motion pictures--Japan--History--20th century, Performing arts, History in motion pictures, Economics in motion pictures, Video recordings, Electronic books
Abstract

From the mid-1950s to the mid-1970s, Japan experienced an unprecedented level of economic growth, transforming itself from a war-devastated country to a global economic power. Our image of postwar Japan has been shaped by this event, and we tend to see its history as a story of great national success. Cinema of Discontent challenges this view and details the tensions generated by massive and intense capitalist development through analyses of popular cinema produced during the era of high-speed growth. The films discussed in this book, directed by Kawashima Yūzō, Masumura Yasuzō, Inoue Akira, Ezaki Mio, and Kumashiro Tatsumi, attracted broad audiences yet remain understudied. Cinema of Discontent contextualizes these films in relation to the politics, economy, intellectual discourse, and cultural texts of the time. By doing so, it demonstrates how these films address problems immanent to Japan's postwar capitalism, including uneven development, increasing corporate control over individuals, precarious and contingent work, and militarized peace and prosperity.

Published
2022

18. Biomedical Engineering

Author

Akihiro Miyauchi, Yuji Miyahara, Akihiro Miyauchi, and Yuji Miyahara

Subjects
Biomedical engineering
Abstract

Several developed countries are facing serious problems in medical environments owing to the aging society, and extension of healthy lifetime has become a big challenge. Biomedical engineering, in addition to life sciences and medicine, can help tackle these problems. Innovative technologies concerning minimally invasive treatment, prognosis and early diagnosis, point-of-care testing, regenerative medicine, and personalized medicine need to be developed to realize a healthy aging society. This book presents cutting-edge research in biomedical engineering from materials, devices, imaging, and information perspectives. The contributors are senior members of the Research Center for Biomedical Engineering, supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. All chapters are results of collaborative research in engineering and life sciences and cover nanotechnology, materials, optical sensing technology, imaging technology, image processing technology, and biomechanics, all of which are important areas in biomedical engineering. The book will be a useful resource for researchers, students, and readers who are interested in biomedical engineering.

Published
2022

19. Research from University of Tsukuba Reveals New Findings on Nutritional and Metabolic Diseases and Conditions (Effects of High-Fat Diet on the Gut Microbiota of Renalase Gene Knockout Mice)

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Microbiota (Symbiotic organisms) -- Analysis -- Research, Genes -- Analysis -- Research, Mice -- Analysis -- Research, Health, University of Tsukuba
Abstract

2022 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on nutritional and metabolic diseases and conditions have been presented. According [...]

Published
2022

20. 8-K: HeartCore Enterprises, Inc

Subjects
United States. Securities and Exchange Commission, OTC Markets Group, Inc., Securities industry, Securities industry, Business, general
Abstract

(EDGAR Online via COMTEX) -- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of [...]

Published
2022

21. Patent Issued for Silicon Nitride Substrate And Silicon Nitride Circuit Board Using The Same (USPTO 10,322,934)

Subjects
Aluminum compounds -- Reports, Printed circuit boards -- Reports, Silicon -- Reports, Electronics industry -- Intellectual property -- Reports, Nitrides -- Reports, Silicon compounds -- Reports, Editors, Printed circuit board, Electronics industry, Electronics
Abstract

2019 JUL 2 (VerticalNews) -- By a News Reporter-Staff News Editor at Electronics Newsweekly -- From Alexandria, Virginia, VerticalNews journalists report that a patent by the inventors Nakayama, Noritaka (Yokohama, [...]

Published
2019

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